A kind of indapamide sustained-release tablet production equipment

Abstract

The present invention relates to the technical field of preparation of antihypertensive sustained-release drugs, and in particular to a kind of indapamide sustained-release tablet production equipment, including a tablet pressing device used in a production step, the tablet pressing device includes a top plate fixedly connected to the top of a support, a vibration motor fixedly connected to the top of the top plate, the top plate and a hopper fixedly connected, two groups of clamps fixedly connected to one side of the support, a quantitative disk rotatably connected between the two groups of clamps, the top of the clamp and the bottom of the hopper are fitted, and a mold barrel is provided below the bottom opening of the clamp. The present invention conveys raw material powder through the cooperation of the quantitative disk and the two groups of clamps, after starting the vibration motor, during the rotation of the quantitative disk, the holes inside the quantitative disk can be filled with raw material powder, and then the powder is fully sent to the inside of the mold barrel, effectively preventing the adhesion of the powder on the surface of the conveying device, avoiding the situation of insufficient addition of raw materials, and reducing the possibility of quality problems of finished tablets.

Description

Technical Field

[0001] The invention relates to the technical field of preparation of antihypertensive sustained-release drugs, in particular to a production device for indapamide sustained-release tablets. Background Art

[0002] Indapamide sustained-release tablets are mainly used to treat primary hypertension. They can regulate human blood pressure after taking them. Indapamide sustained-release tablets can slowly release the drugs in the tablets over a relatively long period of time, thereby maintaining the blood drug concentration in the patient's body during a medication cycle, avoiding the drug from being excreted in large quantities due to human metabolism, ensuring the efficacy of the drug, avoiding patients from repeatedly taking the drug in a short period of time, reducing the psychological burden of patients on taking medication, and also reducing the financial burden of patients.

[0003] The patent document (CN202020222731.1) proposes an indapamide sustained-release tablet pressing device, the main technical solution of which is to set a model groove on the conveyor belt, and set a push rod that matches the clearance of the conveyor belt at the center of the bottom of the model groove. The push rod extends out of the conveyor belt, and a top head is fixed on the top of the push rod. A plurality of strip grooves arranged around the axis of the push rod are set at the bottom of the model groove and the position where the top head and the model groove are in contact. A spring is fixed at the bottom of the strip groove and fixed to the bottom surface of the top head. When the conveyor belt is running, the conveyor belt contacts the roller. The roller squeezes the ejector rod so that the ejector head on the ejector rod pushes into the mold groove, so that the ejector head separates the compressed tablets from the bottom and inner wall of the mold groove, thereby avoiding the problem that the compressed tablets are not easy to fall out of the mold groove. At the same time, a filling cover is arranged on the discharge pipe, which completely covers the mold groove, and the cavity formed between the filling cover and the conveyor belt is always filled with powder, so that the conveyor belt can continuously fill the mold groove in the filling cover with powder during operation, and no powder will overflow during the entire filling process.

[0004] Traditional indapamide sustained-release tablet production equipment solves the problem of dust in tablet feeding and can easily take out tablets from the mold, but the following problems still exist: in the process of using the equipment to press the raw material powder, the powder needs to be added into the inside of the mold, and then the powder is pressed into tablets. During the powder adding process, the powder adheres to the inner wall of the container and the pipe, resulting in insufficient powder addition, and quantitative addition of powder cannot be achieved, resulting in deviations in the quality of individual tablets, which affects the quality of the tablets. Summary of the invention

[0005] The purpose of the present invention is to solve the following problems existing in the prior art: in the actual production process of traditional indapamide sustained-release tablet production equipment, the quality of individual tablets may deviate due to powder adhesion to the inner walls of containers and pipes, thereby affecting the quality of the tablets.

[0006] In order to solve the problems existing in the prior art, the present invention provides a production process and production equipment of indapamide sustained-release tablets, comprising the following steps:

[0007] Step 1: Adding hypromellose, microcrystalline cellulose, povidone, magnesium stearate and indapamide to a powder mixer in sequence for stirring and mixing, the powder mixer controls the speed during use to prevent the raw materials from being contaminated by powder generated by friction during the stirring process of the mixer;

[0008] Step 2: During the mixing process, air is blown into the powder mixer from the bottom or top of the powder mixer, and the air introduced by the blower is dried in advance;

[0009] Step 3: storing the mixed powder in a container under a sterile environment and sealing the container;

[0010] Step 4: Add the drug powder stored in the container to the tableting equipment in a sterile operating environment;

[0011] Step 5: Sampling and batch visual inspection of the tablets produced by the tableting equipment, and storing the qualified tablets in sterile transport containers;

[0012] Step 6: Coat the compressed tablets with ethyl cellulose.

[0013] Preferably, the tablet pressing equipment includes a top plate fixedly connected to the top of the bracket, a vibration motor fixedly connected to the top of the top plate, the top plate and the hopper fixedly connected, two groups of clamps fixedly connected to one side of the bracket, a quantitative disk rotatably connected between the two groups of clamps, the top of the clamps and the bottom of the hopper are fitted together, and a mold barrel is arranged below the bottom opening of the clamps. Through such a design, the operator conveys the raw material powder through the cooperation of the quantitative disk and the two groups of clamps. After starting the vibration motor, during the rotation of the quantitative disk, the holes inside the quantitative disk can be filled with the raw material powder, and then the powder is fully fed into the interior of the mold barrel, which effectively prevents the powder from sticking to the surface of the conveying device, avoids the situation of insufficient raw material addition, and reduces the possibility of quality problems in the finished tablets.

[0014] Preferably, a belt is provided on the outside of the quantitative disk, and the end of the belt away from the quantitative disk is provided on the bottom end of the feeding motor, and the top end of the feeding motor and the bottom end of the top plate are fixedly connected. Through such a design, after starting the feeding motor, the feeding motor drives the quantitative disk to rotate through the belt, thereby improving the convenience of the device.

[0015] Preferably, the bracket and the sensor are fixedly connected, a reflector is glued to the side of the mold cylinder away from the circulation motor, the reflector and the sensor are arranged on the same horizontal line, and the output end of the sensor is electrically connected to the input end of the feeding motor. Through such a design, the cooperation of the sensor and the reflector can be used to judge the operating status of the device and perform subsequent operations without manual control of the equipment operation, thereby improving the convenience of the device.

[0016] Preferably, the bottom end of the mold barrel extends to the interior of the collecting bucket, a placement groove is fixedly connected to the interior of the collecting bucket, a circulation motor is fixedly connected to the interior of the placement groove, the output shaft of the circulation motor is fixedly connected to the side of the mold barrel, and the input end of the circulation motor is electrically connected to the output end of the feeding motor.

[0017] Preferably, the bottom end of the collecting bucket is fixedly connected to the support frame, and the support frame passes through the bracket. Through such a design, the collecting bucket and the components inside the collecting bucket are not connected to the bracket and the components installed on the surface of the bracket. The vibration motor will not cause the collecting bucket and the components inside the collecting bucket to vibrate during operation. When the mold cylinder is loaded with a large amount of raw material powder, the powder will not be spilled due to vibration, thereby improving the practicability of the device.

[0018] Preferably, a pneumatic push rod is fixedly connected to the side of the top end of the top plate away from the vibration motor, and a tablet pressing rod is arranged at the bottom end of the pneumatic push rod. The diameter of the bottom end of the tablet pressing rod is equal to the inner diameter of the mold barrel, and the tablet pressing rod and the mold barrel are symmetrically arranged relative to the circulation motor in the horizontal direction. The input end of the pneumatic push rod is electrically connected to the output end of the circulation motor. Through such a design, the tablet pressing operation can be completed conveniently by starting the pneumatic push rod to drive the tablet pressing rod into the interior of the mold barrel.

[0019] Preferably, the tablet pressing rod is slidably connected with a chuck inside, the top of the chuck is fixedly connected to the bottom end of the pneumatic push rod, the arc-shaped spring sheets inlaid on both sides of the chuck are embedded in the grooves opened on the inner wall of the tablet pressing rod, the bottom end of the chuck is fixedly connected to the sliding rod, the sliding rod and the tablet pressing rod are slidably connected, and grooves are opened at the bottom ends of both sides of the tablet pressing rod, and the bottom ends of the grooves extend to the through holes opened inside the tablet pressing rod. Through such a design, when the pneumatic push rod is started, the tablet pressing rod, the chuck and the sliding rod are pushed into the interior of the mold barrel. During the tablet pressing operation, the continuously running vibration motor drives the tablet pressing rod to vibrate through the top plate and the pneumatic push rod. When the vibrating tablet pressing rod enters the interior of the mold barrel, the raw material powder adhered to the opening of the mold barrel is vibrated and can gradually move downward to the bottom end of the opening of the mold barrel, and enter the hole inside the tablet pressing rod through the groove on the surface of the tablet pressing rod, and finally enter the interior of the mold barrel, thereby avoiding the problem of insufficient quality of tablets.

[0020] Preferably, the top opening of the mold cylinder is set to be trumpet-shaped, and a plug is embedded in the bottom end of the mold cylinder, the plug and the mold cylinder are slidably connected, a semicircular ring is slidably connected inside the mold cylinder, the semicircular ring and the mold cylinder are elastically connected, an extrusion rod is embedded between the mold cylinder and the semicircular ring, the bottom end of the extrusion rod is fixedly connected to the plug, and the two ends of the plug are respectively slidably connected to a group of annular rails, and the two groups of annular rails are respectively opened on the inner wall of the collecting bucket and the outer wall of the placing groove, and an air intake pipe is embedded on the back of the collecting bucket. Through such a design, after the tablet pressing operation is completed, the plug and the extrusion rod are moved away from the mold cylinder in the vertical direction by moving the plug downward, and the two groups of semicircular rings will also move away from each other under the action of the spring, so that the tablets can be easily demolded, and the tablets fall to the top of the plug, and under the blowing of the airflow ejected from the air intake pipe, the tablets fall into the interior of the collecting bucket, and the operator can collect the tablets under the collecting bucket, which effectively avoids the problem that the tablets in the traditional tablet pressing device are not easy to demold.

[0021] Preferably, a section of the annular rail opened on the back side of the inner wall of the collecting hopper and the back side of the outer wall of the placing groove is arranged in an arc shape in the vertical direction. Through such a design, when the plug follows the rotation of the mold cylinder, after the tableting operation is completed, the plug moves downward relative to the mold cylinder under the guidance of the annular rail, and the tablets can be demolded without the need for further assistance from other external forces, which reflects the better linkage of the device and improves the convenience of the device.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] 1. After starting the feeding motor, the feeding motor drives the quantitative disk to rotate through the belt. During the rotation process, the quantitative disk transports the raw material powder inside the hopper to the inside of the mold barrel through the cooperation of two sets of clamping plates. After starting the vibration motor, the holes inside the quantitative disk can be filled with raw material powder, and during the rotation process, the powder is fully fed into the inside of the mold barrel, effectively avoiding the adhesion of raw material powder on the surface of the conveying device, avoiding insufficient raw material addition, and reducing the possibility of quality problems in the finished tablets.

[0024] 2. When the pneumatic push rod is started, it pushes the tablet pressing rod, chuck and slide rod into the interior of the mold barrel. During the tablet pressing operation, the continuously running vibration motor drives the tablet pressing rod to vibrate through the top plate and the pneumatic push rod. When the vibrating tablet pressing rod enters the interior of the mold barrel, the raw material powder adhered to the opening of the mold barrel is vibrated and can gradually move downward to the bottom end of the mold barrel opening, and enter the hole inside the tablet pressing rod through the groove on the surface of the tablet pressing rod, and finally enter the interior of the mold barrel, avoiding the problem of insufficient quality of tablets.

[0025] 3. After the tableting operation is completed, the plug rotates with the mold barrel. Guided by the annular rail, the plug and the extrusion rod are vertically away from the mold barrel. The two sets of semicircular rings are also away from each other under the action of the spring, so that the tablets can be easily demoulded. The tablets fall to the top of the plug and fall into the collection bucket under the airflow from the air inlet pipe. The operator can collect the tablets under the collection bucket, which effectively avoids the problem of tablets being difficult to demould in traditional tableting devices. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a schematic front view of the structure of the present invention;

[0027] Figure 2 For the present invention Figure 1 A is an enlarged schematic diagram of the local structure;

[0028] Figure 3 It is a schematic front cross-sectional view of the partial structure of the support, hopper and mold barrel of the present invention;

[0029] Figure 4 It is a front view cross-sectional schematic diagram of the partial structure of the annular rail, the collecting bucket, the placement trough and the circulating motor of the present invention;

[0030] Figure 5 For the present invention Figure 4 A magnified schematic diagram of the local structure at B in the middle;

[0031] Figure 6 It is a schematic top view cross-sectional view of the local structure of the mold cylinder, the extrusion rod and the semicircular ring of the present invention;

[0032] Figure 7 It is a schematic front view cross-sectional view of the partial structure of the mold cylinder, the plug, the collecting hopper and the tablet pressing rod in the tablet pressing state of the present invention;

[0033] Figure 8 It is a right side cross-sectional schematic diagram of the partial structure of the annular rail and the collecting bucket in the unloading state of the present invention;

[0034] Fig. 9 For the present invention Figure 8 A magnified schematic diagram of the local structure at C in the middle;

[0035] Fig.10 It is a right side schematic diagram of the partial structure of the annular rail and the placement groove of the present invention;

[0036] Fig.11 It is a schematic top view cross-sectional view of the local structure of the bracket and the support frame of the present invention.

[0037] 1. Reference numerals: 110, bracket; 120, top plate; 121, vibration motor; 130, sensor; 131, reflector; 210, hopper; 211, clamp; 212, metering disc; 213, belt; 214, feeding motor; 220, mold cylinder; 221, plug; 222, extrusion rod; 223, semicircular ring; 224, ring rail; 225, air inlet pipe; 310, collecting bucket; 311, placement groove; 312, circulation motor; 320, support frame; 330, pneumatic push rod; 331, tablet pressing rod; 332, chuck; 333, slide rod. DETAILED DESCRIPTION

[0038] In order to make the technical means, creative features, objectives and effects of the present invention easy to understand, the present invention is further described below in conjunction with specific embodiments and drawings, but the following embodiments are only preferred embodiments of the present invention, not all. Based on the embodiments in the implementation mode, other embodiments obtained by those skilled in the art without creative work are all within the scope of protection of the present invention.

[0039] The specific embodiments of the present invention are described below with reference to the accompanying drawings.

[0040] Example 1

[0041] A production process of indapamide sustained-release tablets comprises the following steps:

[0042] Step 1: Adding hydroxypropyl methylcellulose, microcrystalline cellulose, povidone, magnesium stearate and indapamide to a powder mixer in sequence for stirring and mixing, the powder mixer controls the rotation speed during use to prevent the raw materials from being contaminated by powders generated by friction during the stirring process of the mixer, and the tablets made of the above raw materials have a relatively stable shape, and after a human body takes the tablets made of the above raw materials, the tablets have a sustained release effect;

[0043] Step 2: During the mixing process, air is blown into the powder mixer from the bottom or top. The air introduced by the blower has been dried in advance, which can improve the uniformity of the raw material mixing and dry the raw material powder at the same time;

[0044] Step 3: Store the mixed powder in a container under a sterile environment and seal the container to prevent the mixed raw materials from being contaminated;

[0045] Step 4: Add the drug powder stored in the container to the tableting equipment in a sterile operating environment;

[0046] Step 5: Sampling and batch visual inspection of the tablets produced by the tableting equipment are carried out, and the qualified tablets are stored in sterile transport containers. Sampling inspection can make more accurate statistics on the quality of the tablets, and batch visual inspection is used to inspect the appearance of the tablets;

[0047] Step 6: Use ethyl cellulose to coat the compressed tablets. The coating can increase the shelf life of the tablets and cover up the unpleasant odor of the tablets.

[0048] Example 2

[0049] like Figure 1-11 As shown, an indapamide sustained-release tablet production equipment has the function of quantitatively adding raw material powder, and its specific structure is as follows: a top plate 120 is welded to one side of the vertical rod part of the bracket 110, and a support rod is welded between the base of the bracket 110 and the top plate 120, a hopper 210 is embedded in the hole opened inside the top plate 120, and the top plate 120 and the hopper 210 are welded, a vibration motor 121 is installed on the top of the top plate 120 using bolts and clamping parts, a quantitative disk 212 is rotatably connected between two sets of clamping plates 211 using bearings and a rotating shaft, and the clamping plates 211 and the bracket 110 are welded, the top opening of the clamping plates 211 coincides with the bottom opening of the hopper 210, and the top end of the clamping plates 211 fits with the bottom end of the hopper 210, a belt 213 is sleeved on the outside of the quantitative disk 212, and the belt 213 is moved away from the quantitative disk 2 One end of 12 is sleeved on the bottom end of the feeding motor 214, and the feeding motor 214 is installed on the bottom end of the top plate 120 with bolts, and the support frame 320 is placed in the internal opening of the bracket 110, and the collecting bucket 310 is welded to the top end of the support frame 320, and the placement groove 311 is welded inside the collecting bucket 310, and the circulation motor 312 is installed inside the placement groove 311 with bolts, and the mold cylinder 220 is welded on one side of the output shaft of the circulation motor 312, so that the top end of the mold cylinder 220 and the bottom end of the clamping plate 211 are kept in contact, and the top opening of the mold cylinder 220 and the bottom opening of the clamping plate 211 overlap, and the sensor 130 is installed in the middle of the bracket 110, and the reflector 131 is glued to the side of the mold cylinder 220 away from the circulation motor 312, so that the sensor 130 and the reflector 131 are kept at the same level.

[0050] Principle description: During the use of the device, the vibration motor 121 set on the top of the top plate 120 is first started. Then, when the sensor 130 receives the signal reflected by the reflector 131, the sensor 130 starts the feeding motor 214. The feeding motor 214 drives the quantitative disk 212 to rotate one circle through the belt 213, and the raw material powder in the hopper 210 is added to the mold barrel 220. After starting, the vibration motor 121 can drive the top plate 120 and the bracket 110 to vibrate, which can effectively avoid the drug raw materials from vibrating. The powder adheres to the inner walls of the hopper 210 and the splint 211, and the gaps between the drug powder can be effectively filled. When the holes inside the quantitative disk 212 overlap with the holes in the upper splint 211, a sufficient amount of powder can enter the holes inside the quantitative disk 212. When the holes inside the quantitative disk 212 overlap with the holes in the lower splint 211, under the action of the vibration motor 121, the powder transported by the quantitative disk 212 can completely pass through the holes inside the lower splint 211 and enter the interior of the mold barrel 220.

[0051] This device has the function of pressing sheets, and its specific structure is as follows: the pneumatic push rod 330 is installed on the top of the top plate 120, and the bottom end of the pneumatic push rod 330 and the chuck 332 slidably connected inside the sheet pressing rod 331 are welded together, and the bottom end of the chuck 332 and the top end of the sliding rod 333 are welded.

[0052] Principle description: After the feeding motor 214 drives the quantitative disk 212 to rotate one circle, the feeding motor 214 starts the circulation motor 312. After the circulation motor 312 is started, the circulation motor 312 drives the mold barrel 220 to rotate half a circle. Then the circulation motor 312 stops rotating and starts the pneumatic push rod 330. After the pneumatic push rod 330 is started, it pushes the tableting rod 331, the chuck 332 and the slide bar 333 into the interior of the mold barrel 220 to perform tableting operation on the raw material powder inside the mold barrel 220. During this process, the continuously running vibration motor 121 drives the top plate 120, the pneumatic push rod 330, the tableting rod 331, the chuck 332 and the slide bar 333 to vibrate. During the process of the vibrating tableting rod 331 entering the mold barrel 220, the raw material powder adhered to the opening of the mold barrel 220 gradually moves downward to the opening of the mold barrel 220 The bottom end of the opening, and enters the hole inside the tablet pressing rod 331 through the groove on the surface of the tablet pressing rod 331, and finally enters the interior of the mold barrel 220. During the tablet pressing process of the tablet pressing rod 331, the powder inside the mold barrel 220 will enter the channel opened at the bottom of the tablet pressing rod 331. When the tablet pressing rod 331 presses the powder inside the mold barrel 220 to a certain extent, the pneumatic push rod 330 will push the chuck 332 to disengage from the engagement with the tablet pressing rod 331, so that the chuck 332, the slide bar 333 and the tablet pressing rod 331 slide relative to each other, and the slide bar 333 tablets the powder entering the tablet pressing rod 331 until the tablet is formed. When the device fails and the raw material powder is insufficiently added, the slide bar 333 will press a hole on the top surface of the tablet, so that the operator can quickly and directly find the problem when inspecting the finished tablets.

[0053] This equipment has the function of convenient material discharge, and its specific structure is as follows: the bottom end of the mold barrel 220 is elastically connected with a semicircular ring 223 through a spring, and the semicircular ring 223 and the mold barrel 220 are slidably connected, and a plug 221 is embedded in the bottom end of the mold barrel 220, and the top two sides of the plug 221 are respectively fixedly connected with extrusion rods 222, and the extrusion rods 222 are stuck between the inner wall of the mold barrel 220 and the semicircular ring 223, and the inner wall of the collecting bucket 310 and the outer wall of the placing groove 311 are respectively provided with annular rails 224, and the bottom two sides of the plug 221 are respectively slidably connected with a group of feeding motors 214 through sliders, and one end of the air intake pipe 225 is embedded in the back of the collecting bucket 310.

[0054] Principle description: After the tableting operation is completed, the circulating motor 312 continues to drive the mold barrel 220 to rotate. Under the guidance of the annular rail 224, in the vertical direction, the plug 221 gradually moves away from the mold barrel 220, and the extrusion rod 222 moves away from the extrusion rod 222 driven by the plug 221, so that the two groups of semicircular rings 223 move away from each other under the action of the spring, and the tablets sandwiched between the two groups of semicircular rings 223 fall above the plug 221. When passing near the air inlet pipe 225, the tablets above the plug 221 are blown by the air flow and fall into the collecting bucket 310. The operator can collect the tablets below the collecting bucket 310.

[0055] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments. The above embodiments and descriptions are only preferred examples of the present invention and are not intended to limit the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. An indapamide sustained-release tablet production device, characterized in that: The production equipment comprises a top plate (120) fixedly connected to the top of a bracket (110), a vibration motor (121) fixedly connected to the top of the top plate (120), the top of the top plate (120) being fixedly connected to the hopper (210), the top of the top plate (120) being fixedly connected to two groups of clamping plates (211) fixedly connected to one side of the bracket (110), a quantitative disk (212) being rotatably connected between the two groups of clamping plates (211), the top of the clamping plates (211) being in contact with the bottom of the hopper (210), and a mold cylinder (220) being arranged below the bottom opening of the clamping plates (211); The quantitative disk (212) is provided with a belt (213) on its exterior, and one end of the belt (213) away from the quantitative disk (212) is provided on the bottom end of a feeding motor (214), and the top end of the feeding motor (214) and the bottom end of the top plate (120) are fixedly connected; The bottom end of the mold barrel (220) extends to the interior of the collecting bucket (310), a placement groove (311) is fixedly connected to the interior of the collecting bucket (310), a circulation motor (312) is fixedly connected to the interior of the placement groove (311), an output shaft of the circulation motor (312) is fixedly connected to the side of the mold barrel (220), and an input end of the circulation motor (312) is electrically connected to an output end of the feeding motor (214); The bottom end of the collecting bucket (310) is fixedly connected to the support frame (320), and the support frame (320) passes through the bracket (110); A pneumatic push rod (330) is fixedly connected to a side of the top of the top plate (120) away from the vibration motor (121); a tablet pressing rod (331) is arranged at the bottom end of the pneumatic push rod (330); the bottom end diameter of the tablet pressing rod (331) is equal to the inner diameter of the mold cylinder (220); the tablet pressing rod (331) and the mold cylinder (220) are symmetrically arranged relative to the circulation motor (312) in the horizontal direction; and the input end of the pneumatic push rod (330) is electrically connected to the output end of the circulation motor (312); The tablet pressing rod (331) is slidably connected to a chuck (332) inside, the top of the chuck (332) is fixedly connected to the bottom of the pneumatic push rod (330), the arc-shaped spring sheets inlaid on both sides of the chuck (332) are embedded in grooves provided on the inner wall of the tablet pressing rod (331), the bottom of the chuck (332) is fixedly connected to the slide rod (333), the slide rod (333) and the tablet pressing rod (331) are slidably connected, and grooves are provided at the bottom ends of both sides of the tablet pressing rod (331), and the bottom ends of the grooves extend to through holes provided inside the tablet pressing rod (331).

2. The indapamide sustained-release tablet production equipment according to claim 1, characterized in that: The bracket (110) and the sensor (130) are fixedly connected, a reflective plate (131) is glued to a side of the mold cylinder (220) away from the circulation motor (312), the reflective plate (131) and the sensor (130) are arranged on the same horizontal line, and an output end of the sensor (130) is electrically connected to an input end of the feeding motor (214).

3. The indapamide sustained-release tablet production equipment according to claim 1, characterized in that: The top opening of the mold barrel (220) is arranged in a trumpet shape. A plug (221) is embedded in the bottom end of the mold barrel (220). The plug (221) and the mold barrel (220) are slidably connected. A semicircular ring (223) is slidably connected inside the mold barrel (220). The semicircular ring (223) and the mold barrel (220) are elastically connected. An extrusion rod (222) is embedded between the mold barrel (220) and the semicircular ring (223). The bottom end of the extrusion rod (222) is fixedly connected to the plug (221). Both ends of the plug (221) are slidably connected to a group of annular rails (224). The two groups of annular rails (224) are respectively arranged on the inner wall of the collecting bucket (310) and the outer wall of the placement groove (311). An air intake pipe (225) is embedded on the back of the collecting bucket (310).

4. The indapamide sustained-release tablet production equipment according to claim 3, characterized in that: A section of the annular rail (224) opened on the back side of the inner wall of the collecting bucket (310) and the back side of the outer wall of the placement groove (311) is arranged in an arc shape in the vertical direction.

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