Composition for hydrocolloid acne patch, hydrocolloid mixture, hydrocolloid acne patch, and preparation method

Abstract

The present application provides a composition, a hydrocolloid mixture, a hydrocolloid acne patch, and a preparation method for a hydrocolloid acne patch, and relates to the technical field of medical supplies. The raw materials of the composition for the hydrocolloid acne patch include tea tree oil, witch hazel extract, an organic solvent, and peony seed oil. Tea tree oil has anti-inflammatory and moisturizing effects, can inhibit the growth of Propionibacterium acnes, and achieve the effect of removing acne. In addition, its unique fragrant smell helps to refresh the mind. Witch hazel extract contains special soft and sensitive factors, which can soothe unstable skin, help the skin to calm down, maintain metabolic balance, and eliminate skin discomfort. In addition, witch hazel extract also has anti-inflammatory and inhibits the growth of acne bacteria, and can play a synergistic and synergistic role with tea tree oil in anti-inflammatory and antibacterial effects. Organic solvents and peony seed oil can promote the dissolution and absorption of active ingredients, so as to quickly exert their effects.

Description

Technical Field

[0001] The present application relates to the technical field of medical supplies, and in particular to a composition, a hydrocolloid mixture, a hydrocolloid acne patch, and a preparation method thereof. Background Art

[0002] Acne patches are made of special hydrophilic hydrocolloids as the main raw material. Due to its wet healing mechanism, hydrocolloid acne patches can absorb mild to moderate exudates, promote wound healing, and will not form scabs or leave scars. They can be used to treat acne wounds with exudates. Acne patches are transparent, so foundation can be applied on them, which is very suitable for use before makeup. Due to the convenience of using acne patches, more and more people tend to buy this kind of acne-removing patch products to treat acne and maintain skin, which has led to the rapid growth of the acne patch market.

[0003] However, most of the existing acne patches only involve minor upgrades in appearance and packaging structure, and few have conducted deeper research on the formula. The existing acne patches are less effective in inhibiting acne and calming the skin. Summary of the invention

[0004] The purpose of the present application is to provide a composition for a hydrocolloid acne patch, a hydrocolloid mixture, a hydrocolloid acne patch, and a preparation method. The hydrocolloid acne patch prepared from the composition for a hydrocolloid acne patch is intended to solve the problem that the existing acne patches have poor effects in inhibiting acne and calming the skin.

[0005] To achieve the above objectives, the present application provides a composition for a hydrocolloid acne patch, wherein the raw materials of the composition include, by weight:

[0006]

[0007] Preferably, the raw materials of the composition include, by weight: 7-12 parts of tea tree oil, 15-20 parts of witch hazel extract, 50-70 parts of organic solvent, and 10-15 parts of peony seed oil;

[0008] Preferably, the organic solvent includes any one of polyethylene glycol and white mineral oil.

[0009] The present application also provides a method for preparing the above-mentioned composition for hydrocolloid acne patch, comprising:

[0010] The organic solvent and the peony seed oil are mixed and stirred according to a ratio to obtain a mixed solution;

[0011] The tea tree oil and the witch hazel extract are added into the mixed solution and stirred to obtain the composition.

[0012] The present application also provides a hydrocolloid mixture, comprising hydrocolloid and the above-mentioned composition for the hydrocolloid acne patch.

[0013] Preferably, the hydrocolloid mixture comprises, by weight:

[0014] Hydrocolloid 100 parts;

[0015] 2-8 parts of the composition for hydrocolloid acne patch.

[0016] The present application also provides a method for preparing the above-mentioned hydrocolloid mixture, comprising:

[0017] Melting and mixing the hydrocolloid at 110° C. to 130° C. for 0.5 h to 1 h to obtain a melt;

[0018] The melt is cooled to 80° C.-90° C., and the composition for a hydrocolloid acne patch is added and mixed for 20-30 minutes to obtain the hydrocolloid mixture.

[0019] The present application also provides a hydrocolloid acne patch, comprising a main body layer, a hydrocolloid layer arranged on the main body layer, and a release film layer arranged on the hydrocolloid layer, wherein the hydrocolloid layer is obtained by pressing the above-mentioned hydrocolloid mixture into a sheet.

[0020] Preferably, the thickness of the hydrocolloid layer is 0.2-0.8 mm.

[0021] Preferably, the main body layer is a polyurethane film layer, and the thickness of the main body layer is 15-30 μm.

[0022] The present application also provides a method for preparing the above-mentioned hydrocolloid acne patch, comprising:

[0023] Placing the hydrocolloid mixture on the release film layer and pressing it into a sheet;

[0024] The main body layer and the sheet are compounded to obtain the hydrocolloid acne patch.

[0025] Compared with the prior art, the beneficial effects of this application include:

[0026] The raw materials of the composition for hydrocolloid acne patch provided by the present application include tea tree oil, witch hazel extract, polyethylene glycol and peony seed oil. Tea tree oil has anti-inflammatory and moisturizing effects, can inhibit the growth of Propionibacterium acnes, achieve the effect of acne removal, and its unique fragrant smell helps to refresh the mind. Witch hazel extract contains special soft sensitive factors, which can soothe unstable skin, help the skin to calm down, maintain metabolic balance, and eliminate skin discomfort. In addition, witch hazel extract also has anti-inflammatory and inhibits the growth of acne bacteria, and can play a synergistic and synergistic role with tea tree oil in anti-inflammatory and antibacterial effects. Organic solvents, as good solvents, can dissolve active ingredients such as tea tree oil and witch hazel extract and other inactive ingredients; peony seed oil has the effect of promoting transdermal absorption of active ingredients, making active components more easily absorbed through the skin, so as to quickly exert their effects.

[0027] The composition for hydrocolloid acne patch is added to the hydrocolloid acne patch, which can play the role of inhibiting bacteria and inflammation, assisting in cleaning and calming the skin for acne with pus heads and secretions, and small-scale wounds and damaged skin, thereby expanding the application range of the hydrocolloid acne patch to a greater extent. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope of the present application.

[0029] Figure 1 This is a schematic diagram of the structure of the hydrocolloid acne patch of the present application;

[0030] Figure 2 A schematic diagram showing the effect of an acne patient before and after using the hydrocolloid acne patch of the present application;

[0031] Figure 3 This is a schematic diagram of the effect of another acne patient before and after using the hydrocolloid acne patch of the present application.

[0032] Reference numerals:

[0033] 10-body layer; 20-hydrocolloid layer; 30-release film layer. DETAILED DESCRIPTION

[0034] As used herein:

[0035] "Prepared from" is synonymous with "comprising." As used herein, the terms "comprising," "including," "having," "containing," or any other variation thereof, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises the listed elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

[0036] The conjunction "consisting of excludes any unspecified element, step, or component. If used in a claim, this phrase renders the claim closed-ended so that it does not include materials other than those described, except for conventional impurities associated therewith. When the phrase "consisting of" appears in a clause of the body of a claim rather than immediately following the subject matter, it limits only the elements described in that clause; other elements are not excluded from the claim as a whole.

[0037] When an amount, concentration, or other value or parameter is expressed as a range, a preferred range, or a range defined by a series of upper preferred values ​​and lower preferred values, this should be understood as specifically disclosing all ranges formed by any pairing of any range upper limit or preferred value with any range lower limit or preferred value, regardless of whether the range is disclosed separately. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted as including ranges "1 to 4", "1 to 3", "1 to 2", "1 to 2 and 4 to 5", "1 to 3 and 5", etc. When a numerical range is described in this article, unless otherwise stated, the range is intended to include its end values ​​and all integers and fractions within the range.

[0038] In these examples, parts and percentages are by mass unless otherwise indicated.

[0039] "Parts by mass" refers to the basic unit of measurement for expressing the mass ratio of multiple components. 1 part can represent any unit mass, such as 1g or 2.689g. If we say that the mass of component A is a parts and the mass of component B is b parts, it means the ratio of the mass of component A to the mass of component B is a:b. Alternatively, it means that the mass of component A is aK and the mass of component B is bK (K is an arbitrary number, indicating a multiple factor). It should not be misunderstood that, unlike the mass parts, the sum of the mass of all components is not limited to 100 parts.

[0040] “And / or” is used to indicate that one or both of the stated situations may occur, for example, A and / or B includes (A and B) and (A or B).

[0041] The present application provides a composition for a hydrocolloid acne patch, wherein the raw materials of the composition include, by weight:

[0042]

[0043] Wherein, tea tree oil is an extract extracted from the leaves of the native species of Australian tea tree. Tea tree oil can be obtained by process extraction or can be purchased. It has anti-inflammatory and moisturizing effects, can inhibit the growth of Propionibacterium acnes, achieve the effect of removing acne, and its unique fragrant smell helps to refresh the mind. The amount of tea tree oil can be, for example, 5-10 parts, or 7-12 parts, or 13-20 parts, and more specifically, for example, can be (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20) parts, or any value between 5-20 parts. Preferably, the amount of tea tree oil is 7-12 parts.

[0044] Among them, witch hazel extract is extracted from the bark and branches of witch hazel shrubs native to North America. The witch hazel extract can be obtained by process extraction or can be purchased. It contains special soft and sensitive factors, which can soothe unstable skin, help the skin to calm down, maintain metabolic balance, and eliminate skin discomfort. In addition, witch hazel extract also has anti-inflammatory and inhibits the growth of acne bacteria, and can play a synergistic and anti-inflammatory and antibacterial synergistic effect with tea tree oil. The amount of witch hazel extract can be, for example, 10-15 parts, or 15-20 parts, and more specifically, for example, it can be (10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20) parts, or any value between 10-20 parts. Preferably, the amount of witch hazel extract is 15-20 parts.

[0045] Among them, the organic solvent includes any one of polyethylene glycol and white mineral oil. The organic solvent, as a good solvent, can dissolve active ingredients such as tea tree oil, witch hazel extract and other inactive ingredients; peony seed oil has the effect of promoting transdermal absorption of active ingredients, making the active components more easily absorbed through the skin, thereby quickly exerting their efficacy.

[0046] The amount of the organic solvent can be, for example, 40-60 parts, or 50-60 parts, or 50-70 parts, or 60-80 parts, more specifically, for example, (40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79 or 80) parts, or any value between 40-80 parts. Preferably, the amount of the organic solvent is 50-70 parts.

[0047] Peony seed oil has the effect of promoting the transdermal absorption of active ingredients, making active components more easily absorbed by the skin, thereby quickly exerting efficacy. Peony seed oil can be obtained by process extraction, and can also be purchased. The consumption of peony seed oil can be, for example, 5-10 parts, or 10-15 parts, or 13-20 parts, more specifically, for example, can be (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20) parts, or any value between 5-20 parts. Preferably, the consumption of peony seed oil is 10-15 parts.

[0048] The present application also provides a method for preparing the above-mentioned composition for hydrocolloid acne patch, comprising:

[0049] The organic solvent and the peony seed oil are mixed and stirred according to a ratio to obtain a mixed solution;

[0050] The tea tree oil and the witch hazel extract are added into the mixed solution and stirred to obtain the composition.

[0051] The present application also provides a hydrocolloid mixture, including a hydrocolloid and the above-mentioned composition for a hydrocolloid acne patch, wherein the hydrocolloid of the present application can be composed, for example, of 35% sodium carboxymethyl cellulose, 13.5% styrene-isoprene-styrene polymer, 13.5% styrene-isoprene polymer, and 38% polyisobutylene by mass percentage.

[0052] The preparation method of the hydrocolloid of the present application may be, for example, as follows:

[0053] The kneader is heated to 180°C, styrene-isoprene-styrene polymer, styrene-isoprene polymer and polyisobutylene are added to the kneader at 180°C, preheated for 1 hour, and the stirrer is started with the front blade rotating at 40-50 rpm / min. After mixing for 40-50 minutes, a uniformly mixed adhesive body is obtained.

[0054] After the adhesive body is thoroughly mixed, the mixer is cooled to 130°C and sodium carboxymethylcellulose is added at this temperature. Mixing is continued at 130°C for 30 minutes until a homogeneous hydrocolloid is obtained.

[0055] Preferably, the hydrocolloid mixture comprises, by weight: 100 parts of hydrocolloid; 2-8 parts of the composition for the hydrocolloid acne patch.

[0056] The amount of the composition used in the hydrocolloid acne patch can be, for example, 2-4 parts, or 4-6 parts, or 3-7 parts, or 5-7 parts, and more specifically, can be, for example, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, or 8 parts. More preferably, the amount of the composition used in the hydrocolloid acne patch is 5-7 parts.

[0057] The present application also provides a method for preparing the above-mentioned hydrocolloid mixture, comprising:

[0058] Melting and mixing the hydrocolloid at 110° C. to 130° C. for 0.5 h to 1 h to obtain a melt;

[0059] The melt is cooled to 80° C.-90° C., and the composition for a hydrocolloid acne patch is added and mixed for 20-30 minutes to obtain the hydrocolloid mixture.

[0060] This application also provides a hydrocolloid acne patch, please refer to Figure 1 , comprising a main body layer 10, a hydrocolloid layer 20 disposed on the main body layer 10 and a release film layer 30 disposed on the hydrocolloid layer 20, wherein the hydrocolloid layer 20 is obtained by pressing the above-mentioned hydrocolloid mixture into a sheet.

[0061] The main body layer 10 is a transparent material layer, serving as the base of the hydrocolloid acne patch. The main body layer 10 may be, for example, a polyurethane film layer, and the thickness of the main body layer 10 is 15-30 μm.

[0062] The thickness of the hydrocolloid layer 20 is 0.2-0.8 mm, the hydrocolloid layer 20 is fixedly arranged on the main body layer 10, and the release film layer 30 is tearably arranged on the hydrocolloid layer 20 to protect the hydrocolloid layer 20. When the hydrocolloid acne patch is used, the release film layer 30 is torn off, and then the hydrocolloid layer 20 is covered on the acne or wound, and the hydrocolloid layer 20 is fixed on the skin.

[0063] The composition for hydrocolloid acne patch is added to the hydrocolloid acne patch, which can play the role of inhibiting bacteria and inflammation, assisting in cleaning and calming the skin for acne with pus heads and secretions, and small-scale wounds and damaged skin, thereby expanding the application range of the hydrocolloid acne patch to a greater extent.

[0064] The present application also provides a method for preparing the above-mentioned hydrocolloid acne patch, comprising:

[0065] Placing the hydrocolloid mixture on the release film layer 30 and pressing it into a sheet;

[0066] The main body layer 10 is compounded with the sheet to obtain the hydrocolloid acne patch.

[0067] Among them, according to the structure of the hydrocolloid acne patch, the main body layer 10 and the hydrocolloid layer 20 pressed into a sheet are compounded, and the hydrocolloid layer 20 can be pasted by coating medical glue on the main body layer 10, or the main body layer 10 and the hydrocolloid layer 20 are compounded by hot melt, and the hydrocolloid is coated on the main body layer 10 in a molten state, and then compounded with a release film paper.

[0068] The embodiments of the present application will be described in detail below in conjunction with specific examples, but it will be appreciated by those skilled in the art that the following examples are only used to illustrate the present application and should not be considered as limiting the scope of the present application. If specific conditions are not specified in the examples, they are carried out according to normal conditions or the conditions recommended by the manufacturer. If the manufacturer is not specified for the reagents or instruments used, they are all conventional products that can be purchased commercially.

[0069] Example 1

[0070] Preparation of the composition for hydrocolloid acne patch:

[0071] 62 parts of polyethylene glycol and 13 parts of peony seed oil (purchased from Ji'an Wanyi Spice Oil Co., Ltd.) were added to a beaker and stirred for 20 minutes under the action of a stirrer to obtain a uniform mixed solution. Then, 9.3 parts of Australian tea tree oil (purchased from Ji'an Zhongxiang Natural Plant Co., Ltd.) and 15.7 parts of witch hazel extract (purchased from Ji'an Zhongxiang Natural Plant Co., Ltd.) were slowly added under continuous stirring, and stirring was continued for 20 to 30 minutes at a constant speed until a uniform mixed solution was obtained to obtain a composition for a hydrocolloid acne patch.

[0072] Preparation of hydrocolloid mixture:

[0073] 100 parts of the hydrocolloid raw material were added to a kneading mixer and melt-mixed for 1 hour, the temperature was set to 130° C. After the hydrocolloid raw material was completely melted, the melt was cooled to about 90° C. 2 parts of the above-prepared composition for hydrocolloid acne patch were added, and mixing was continued for 30 minutes until a uniform material was obtained to obtain a hydrocolloid mixture.

[0074] Preparation of hydrocolloid acne patch:

[0075] The hydrocolloid mixture prepared above was taken out and placed on a release film. While hot, a manual tablet press was used to press the prepared hydrocolloid mixture into a sheet with a thickness of 0.3 mm, and compounded with a polyurethane film with a thickness of 25 microns to form a sheet. The sheet was then die-cut into the required 12 mm acne patch discs to obtain a hydrocolloid acne patch.

[0076] Example 2

[0077] The difference from Example 1 is that 4 parts of the composition for hydrocolloid acne patch are added to the hydrocolloid mixture of Example 2, and the other steps are the same as those of Example 1, which will not be repeated here.

[0078] Example 3

[0079] The difference from Example 1 is that 6 parts of the composition for hydrocolloid acne patch are added to the hydrocolloid mixture of Example 3, and the other steps are the same as those of Example 1, which will not be repeated here.

[0080] Example 4

[0081] The difference from Example 1 is that 8 parts of the composition for hydrocolloid acne patch are added to the hydrocolloid mixture of Example 4, and the other steps are the same as those of Example 1, which will not be repeated here.

[0082] Example 5

[0083] 62 parts of white mineral oil and 13 parts of peony seed oil were added to a beaker, and stirred for 20 minutes under the action of a stirrer to obtain a uniform mixed solution. Then, 9.3 parts of Australian tea tree oil and 15.7 parts of witch hazel extract were slowly added under continuous stirring, and stirring was continued for 20 to 30 minutes at a constant speed until a uniform mixed solution was obtained, thereby obtaining a composition for a hydrocolloid acne patch.

[0084] 100 parts of the hydrocolloid raw material were added to a kneading mixer and melt-mixed for 1 hour, the temperature was set to 130° C. After the hydrocolloid raw material was completely melted, the melt was cooled to about 90° C. 2 parts of the composition for hydrocolloid acne patch prepared above were added, and mixing was continued for 30 minutes until a uniform substance was obtained to obtain a hydrocolloid mixture, and the hydrocolloid mixture was made into a sheet consistent with Example 1.

[0085] Comparative Example 1

[0086] Different from Example 1, the hydrocolloid used in the hydrocolloid acne patch of Comparative Example 1 does not contain the above-mentioned composition for the hydrocolloid acne patch. The preparation method of the hydrocolloid acne patch is the same as that of Example 1, which will not be described again.

[0087] Comparative Example 2

[0088] Unlike Example 1, the composition of the hydrocolloid acne patch used in the hydrocolloid acne patch of Comparative Example 2 does not contain polyethylene glycol. 13 parts of peony seed oil, 9.3 parts of Australian tea tree oil and 15.7 parts of witch hazel extract were added to a beaker and stirred for 20 to 30 minutes under the action of a stirrer until a uniformly mixed mixture was obtained to obtain a composition for a hydrocolloid acne patch. 6 parts of the composition for a hydrocolloid acne patch were added to the hydrocolloid mixture, and the other steps were the same as those in Example 1, which will not be repeated here.

[0089] The hydrocolloid acne patch of Comparative Example 2 was torn off after being applied to the skin for 8 hours, and there was sticky residual glue on the applied position. It was judged that the compatibility of this composition with the hydrocolloid raw material was relatively poor. Since tea tree oil and witch hazel extract are liquids, they will precipitate to the surface of the glue during use, resulting in residual glue. This shows that the compatibility of the composition with the hydrocolloid raw material can be improved by adding polyethylene glycol.

[0090] Test example

[0091] 1. Physical and chemical properties test of hydrocolloid mixture sheets of embodiments and comparative examples

[0092] The hydrocolloid mixture sheets of Examples 3, 4, 5 and Comparative Example 1 were tested for performance indicators such as absorption, water barrier, persistent adhesion, peel strength, extensibility, permanent deformation, pH, and heavy metals. The test methods and test results are shown in Table 1.

[0093] Table 1 Test results of physical and chemical properties of hydrocolloid mixture sheets of Examples 3-5 and Comparative Example 1

[0094]

[0095]

[0096] From the results in Table 1, it can be seen that when the amount of the composition used for the hydrocolloid acne patch added is 6%, the addition of the composition has little effect on the physical and chemical properties of the hydrocolloid mixture sheet, which is almost equivalent to the hydrocolloid mixture sheet without the composition used for the hydrocolloid acne patch. When the amount of the composition used for the hydrocolloid acne patch added is increased to 8%, the peel strength of the hydrocolloid mixture sheet increases sharply, and residual glue appears. It can be seen that the addition amount of the composition used for the hydrocolloid acne patch in the hydrocolloid mixture is less than 8%, which has little effect on the performance indicators of the hydrocolloid mixture sheet.

[0097] After polyethylene glycol was replaced with white mineral oil in Example 5, the peel strength value of the obtained hydrocolloid mixture sheet was relatively large, and there was a slight adhesive residue when it was applied to the skin.

[0098] 2. Antibacterial effect test of hydrocolloid mixture sheets of embodiments and comparative examples

[0099] The hydrocolloid acne patches prepared in Examples 1 to 4 and Comparative Example 1 were uniformly cut into 1.0 x 1.0 cm sizes and placed in a conical flask. Then, the same volumes of phosphate buffer and Propionibacterium acnes bacterial suspension were added respectively, and the concentration of the bacterial suspension in PBS was 1 x 10 4 ~9x10 4 CFU / mL, fix the conical flask on an oscillating shaker and shake it at 300r / min for 1h, take the sample solution before and after shaking respectively, dilute it appropriately with PBS, inoculate it on a plate by agar pouring method, and count the colonies. The inhibition rate is the ratio of the difference between the average colony counts of the test sample before and after shaking to the average colony count before shaking, expressed in percentage.

[0100] Result report: Inhibition rate = 0, no antibacterial effect; Inhibition rate < 50%, the sample has a weak antibacterial effect; Inhibition rate ≥ 50% to 90%, the sample has an antibacterial effect; Inhibition rate ≥ 90%, the sample has a strong antibacterial effect. As shown in Table 2.

[0101] Table 2 Antibacterial test results of hydrocolloid mixture sheets of embodiments and comparative examples

[0102] Group Propionibacterium acnes inhibition rate (%) Antibacterial effect Example 1 (2%) 64.2 Has antibacterial effect Example 2 (4%) 88.4 Has antibacterial effect Example 3 (6%) 93.6 Strong antibacterial effect Example 4 (8%) 94.3 Strong antibacterial effect Comparative Example 1(0) 0 No antibacterial effect

[0103] From the results in Table 2, it can be seen that the addition of the composition for hydrocolloid acne patch has a significant inhibitory effect on Propionibacterium acnes. When the addition content of the composition for hydrocolloid acne patch in the hydrocolloid mixture is 8%, the antibacterial effect is the best. In addition, when the addition amount of the composition for hydrocolloid acne patch is less than 6%, the antibacterial effect is not significantly improved.

[0104] 3. Test on the anti-acne and anti-inflammatory effects of the hydrocolloid acne patch of the embodiment and the comparative example

[0105] Trial subjects: 50 subjects aged between 17 and 40, including men and women, and acne, blackheads, papules, and pustules caused by diet (such as spicy food, sweets), high fat, constipation, climate, mental stress, and female menstruation. Among them, 22 trial subjects had severe acne, blackheads, papules, and pustules, which were type A. 28 trial subjects had moderate to mild blackheads, papules, and severe acne marks, which were type B. The above acne patients were divided into 5 groups on average.

[0106] Directions for use: After cleaning the face, the tester should apply the hydrocolloid acne patch to the acne area, one patch each morning and evening, for two weeks. Do not use it within 2 hours before or 30 minutes after bathing, shaving, sauna or strenuous exercise.

[0107] Effect judgment criteria:

[0108] Cured or obvious effect: acne basically disappeared, acne marks faded;

[0109] Effective: A small amount of acne and papules remain;

[0110] Ineffective: No improvement, or the change is not obvious.

[0111] like Figure 2 and Figure 3 The figures are comparison diagrams of the effects of two patients before and after using the hydrocolloid acne patch of Example 3.

[0112] Table 3 Results of human trial of hydrocolloid acne patch of the embodiment and comparative example

[0113] Group Healed or effective efficient invalid Example 1 (2%) 30％ 50％ 20％ Example 2 (4%) 30％ 60％ 20％ Example 3 (6%) 50％ 40％ 10％ Example 4 (8%) 60％ 30％ 10％ Comparative Example 1(0) 0 60％ 40％

[0114] From the results in Table 3, it can be seen that the addition of the composition for hydrocolloid acne patch can indeed inhibit acne and achieve the effect of removing acne. Among them, the best effect is the acne patch product with an addition amount of 8%, followed by the acne patch product with an addition amount of 6%, and the difference between the two is small. For the acne patch without the composition for hydrocolloid acne patch, although long-term use can also reduce acne and papules, the effect is not obvious.

[0115] In general, the hydrocolloid acne patch added with the composition for hydrocolloid acne patch of the present application has the effects of antibacterial, anti-inflammatory and acne removal. Moreover, the hydrocolloid acne patch added with 6% has better anti-inflammatory and acne removal effects, has little effect on the physical and chemical properties of the hydrocolloid acne patch, and does not have residual glue, which is a more ideal addition amount.

[0116] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit it. Although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present application.

[0117] In addition, those skilled in the art will appreciate that, although some embodiments herein include certain features included in other embodiments but not other features, the combination of features of different embodiments is meant to be within the scope of the present application and form different embodiments. For example, in the above claims, any one of the claimed embodiments may be used in any combination. The information disclosed in this background technology section is intended only to deepen the understanding of the overall background technology of the present application and should not be regarded as an admission or in any form of implication that the information constitutes prior art known to those skilled in the art.

Claims

1. A composition for a hydrocolloid acne patch, characterized in that: The raw materials of the composition are calculated by weight:

2. The composition for hydrocolloid acne patch according to claim 1, characterized in that: The raw materials of the composition are calculated by weight: 7-12 parts of tea tree oil, 15-20 parts of witch hazel extract, 50-70 parts of polyethylene glycol and 10-15 parts of peony seed oil.

3. A method for preparing the composition for a hydrocolloid acne patch according to claim 1 or 2, characterized in that: include: The polyethylene glycol and the peony seed oil are mixed and stirred according to a ratio to obtain a mixed solution; The tea tree oil and the witch hazel extract are added into the mixed solution and stirred to obtain the composition.

4. A hydrocolloid mixture, characterized in that: The invention comprises hydrocolloid and the composition for hydrocolloid acne patch according to claim 1 or 2.

5. The hydrocolloid mixture according to claim 4, characterized in that The hydrocolloid mixture comprises, by weight: Hydrocolloid 100 parts; 2-8 parts of the composition for hydrocolloid acne patch.

6. A method for preparing the hydrocolloid mixture according to claim 4 or 5, characterized in that: include: Melting and mixing the hydrocolloid at 110° C. to 130° C. for 0.5 h to 1 h to obtain a melt; The melt is cooled to 80° C.-90° C., and the composition for a hydrocolloid acne patch is added and mixed for 20-30 minutes to obtain the hydrocolloid mixture.

7. A hydrocolloid acne patch, characterized in that: It comprises a main body layer, a hydrocolloid layer arranged on the main body layer and a release film layer arranged on the hydrocolloid layer, wherein the hydrocolloid layer is obtained by tabletting the hydrocolloid mixture according to claim 4 or 5.

8. The hydrocolloid acne patch according to claim 7, characterized in that: The thickness of the hydrocolloid layer is 0.2-0.8 mm.

9. The hydrocolloid acne patch according to claim 7, characterized in that: The main body layer is a polyurethane film layer, and the thickness of the main body layer is 15-30 μm.

10. A method for preparing the hydrocolloid acne patch according to any one of claims 7 to 9, characterized in that: include: Placing the hydrocolloid mixture on the release film layer and pressing it into a sheet; The main body layer and the sheet are compounded to obtain the hydrocolloid acne patch.

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