A low temperature cryogenic freeze-slice device

By designing the inner and outer sleeves and air intake structure of the low-temperature cryogenic rotary cutting device, and using refrigerant to freeze and fix the tissue before rotary cutting, the problems of incomplete cutting and patient discomfort in existing technologies are solved, achieving efficient and safe breast tissue removal.

CN116327264BActive Publication Date: 2026-06-26ACCUTARGET MEDIPHARMA (SHANGHAI) CO LTD

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ACCUTARGET MEDIPHARMA (SHANGHAI) CO LTD
Filing Date
2023-03-23
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

Existing rotary cutting devices do not provide reliable negative pressure suction when removing breast tissue, making it difficult for the cutting blade to effectively remove elastic tissue, and patients experience discomfort from physical traction during the cutting process.

Method used

The device employs a low-temperature cryo-slicing apparatus. Through the design of inner and outer sleeve structures and air intake structures, it uses refrigerant to freeze tissue and fix it in the sampling slot. Combined with the inner cutting blade, it performs rotary cutting to achieve effective tissue removal and reduces patient discomfort through cryo-analgesia.

Benefits of technology

It improves the efficiency of tissue removal and patient tolerance, ensures the integrity and safety of the cut, reduces the risk of tissue getting stuck in the gap between the cutting blades, and improves the reliability and comfort of the operation.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application discloses a low-temperature freezing rotary cutting device, which is characterized by sequentially sleeving an outer sleeve, an inner sleeve and an inner tube from outside to inside, setting a puncture tip at the head end of the outer sleeve, fixing the tail ends of the outer sleeve and the inner sleeve on a fixing piece, forming an intermediate cavity for the air inlet structure to enter between the outer sleeve and the inner sleeve, setting a sampling groove near the head end of the outer sleeve and the inner sleeve, setting a sealing structure at the intermediate cavity corresponding to the sampling groove position, forming a plurality of release cavities and air inlet chambers communicated with the release cavities, setting the air inlet structure to provide refrigerant to the corresponding release cavities through the air inlet chambers, and setting corresponding freezing holes of the inner sleeve at the release cavities. After the tumor tissue is sucked into the sampling groove under the negative pressure, the refrigerant freezes the tumor tissue through the freezing holes to make the tumor tissue lose the original biological elasticity, and then the tissue is rotary cut through the inner cutting blade on the inner tube, so that the tumor tissue can be effectively removed, and the sampling efficiency is improved.
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Description

Technical Field

[0001] This invention belongs to the field of medical device technology, and in particular relates to a low-temperature cryogenic rotary cutting device. Background Technology

[0002] Breast cancer is a malignant tumor originating from the epithelium of the lobular units of the terminal ducts of the breast. Worldwide, breast cancer has become the most common malignant tumor among women; its mortality rate is rising annually. Distant metastasis of breast cancer is considered a leading cause of cancer death. Therefore, early diagnosis and timely treatment are currently the most effective methods to improve survival rates.

[0003] Breast biopsy is the gold standard for diagnosing breast cancer. Vacuum-assisted excision is a surgical procedure that allows for multiple cuts with a single needle insertion under ultrasound guidance. Clinically, it is commonly used for the removal of benign breast tumors and for biopsy diagnosis of breast cancer.

[0004] Existing technology typically involves the host providing negative pressure to the puncture needle. When the puncture needle reaches the location of the breast tumor, the negative pressure suction draws the tumor into the sampling groove of the puncture needle. Then, the cutting blade removes the tumor from the sampling groove and transports it to the sample collection chamber. This method often fails to achieve effective cutting because the negative pressure suction is not strong enough and there is insufficient adhesion.

[0005] On the other hand, the most common benign breast tumor, fibroadenoma, is a benign tumor composed of a mixture of glandular epithelium and fibrous tissue. It has regular edges, a smooth surface, is elastic, highly mobile, and not adherent to the skin. This elastic biological characteristic often results in sheets of tissue getting stuck around the cutting edge during resection, making effective tissue removal impossible. Summary of the Invention

[0006] The technical problem to be solved by the present invention is to provide a low-temperature cryogenic rotary cutting device to solve the problem that it is difficult to effectively remove tissue in existing rotary cutting device solutions.

[0007] To solve the above problems, the technical solution of the present invention is as follows:

[0008] A cryogenic freezing and slicing apparatus of the present invention includes:

[0009] The fastener has an inner tube opening.

[0010] An inner sleeve is fixed to the fixing member, and the hollow inner cavity of the inner sleeve and the opening of the inner tube cooperate to form a rotary-cut cavity;

[0011] An outer sleeve is fixed to the fixing member and sleeved on the inner sleeve. The first end of the outer sleeve is provided with a puncture tip, and the side facing the puncture tip is defined as the first end, and the side away from the puncture tip is defined as the tail end. An intermediate cavity is formed between the outer sleeve and the inner sleeve. Sampling grooves are radially opened on the inner sleeve and the outer sleeve, which communicate with the rotary cutting cavity and penetrate part of the intermediate cavity. The plane at the tail end of the sampling groove and perpendicular to the axis divides the intermediate cavity into a freezing chamber near the puncture tip and an air inlet chamber away from the puncture tip.

[0012] A sealing structure is provided inside the freezing chamber, and at least one release chamber is provided inside the sealing structure to communicate with the air inlet chamber; wherein, the inner sleeve is provided with at least one row of freezing holes to communicate with the sampling groove and the corresponding release chamber;

[0013] An intake structure is inserted into the outer sleeve, and the output end of the intake structure is connected to the corresponding release chamber via the intake chamber for delivering refrigerant to the release chamber.

[0014] An inner tube extends into and is movably connected to the rotary cutting cavity. The first end of the inner tube is provided with an inner cutting blade, and the tail end of the inner tube is used to connect to the negative pressure end of the main unit.

[0015] After the low-temperature freezing rotary cutting device is positioned at the target location, the target object is drawn in through the negative pressure formed by the rotary cutting cavity and the external negative pressure device in the sampling slot. The refrigerant enters the sampling slot through the air intake structure, the release chamber and the freezing hole to freeze the target object. After freezing is completed, the inner tube and the inner cutting blade rotate forward along the axial direction to cut and separate the target object into the sampling slot.

[0016] The low-temperature freezing rotary cutting device of the present invention has a connecting interface on the outer sleeve that communicates with its inner cavity.

[0017] The air intake structure includes at least one air intake pipe and an air intake pipe interface;

[0018] The first end of the intake pipe interface is sealed and connected to the connection interface, and the tail end of the intake pipe is fixed to the fixing member for connection with the external refrigerant supply unit.

[0019] The intake pipes are all arranged in the intake chamber; the first end of the intake pipe extends into the corresponding release chamber; the tail end of the intake pipe is sealed and connected to the connection interface and communicates with the inner cavity of the intake pipe interface.

[0020] In the low-temperature freezing rotary cutting device of the present invention, the portion of the sealing structure at the tail end of the sampling groove is a tail end sealing surface;

[0021] At least one sealing opening is provided on the tail end sealing surface, which is connected to the release chamber in a one-to-one manner, and the first end of the air intake pipe extends into and is sealed to the sealing opening.

[0022] In the low-temperature freezing rotary cutting device of the present invention, the diameter of the freezing hole is smaller than the inner diameter of the air inlet pipe.

[0023] In the cryogenic freezing rotary cutting device of the present invention, a plurality of the release chambers are distributed circumferentially in the freezing chamber.

[0024] In the low-temperature freezing rotary cutting device of the present invention, the diameter direction of the freezing hole is the diameter direction of the inner sleeve position.

[0025] The low-temperature freezing rotary cutting device of the present invention uses CO2 and N2O as the refrigerant.

[0026] The low-temperature freezing rotary cutting device of the present invention has a fixing member as a fixing sleeve, which is provided with an inner tube opening for the inner tube to pass through and a refrigerant groove and a refrigerant inlet hole that are connected.

[0027] The fixed sleeve is provided with a sleeve mounting groove concentric with the opening of the inner tube, and the tail ends of the inner sleeve and the outer sleeve are respectively sealed and connected in the sleeve mounting groove.

[0028] The tail end of the air intake pipe interface is sealed to the refrigerant slot hole, and the refrigerant inlet hole is used to connect to the external refrigerant supply end.

[0029] In the low-temperature freezing rotary cutting device of the present invention, the outer diameter of the inner cutting blade is less than or equal to the inner diameter of the inner sleeve.

[0030] The low-temperature freezing rotary cutting device of the present invention further includes a dynamic sealing structure disposed between the inner tube opening and the inner tube, for sealing the tube gap between the inner tube opening and the inner tube in a first structural state, so that the tube gap is not connected with the external atmosphere, and connecting the tube gap with the external atmosphere in a second structural state.

[0031] Because the present invention adopts the above technical solution, it has the following advantages and positive effects compared with the prior art:

[0032] 1. In one embodiment of the present invention, an outer sleeve, an inner sleeve, and an inner tube are sequentially arranged from the outside in. The inner tube passes through a fixing member and the inner sleeve, and its first end is provided with an inner cutting blade. The first end of the outer sleeve is provided with a puncture tip. The tail ends of the outer and inner sleeves are fixed to the fixing member, forming an intermediate cavity for the air intake structure to enter. Sampling slots are opened near the first ends of the outer and inner sleeves. A sealing structure is provided at the intermediate cavity corresponding to the sampling slot, forming several release chambers and an air intake chamber connected to them. The air intake structure is configured to provide refrigerant to the corresponding release chambers through the air intake chambers. The inner sleeve is provided with corresponding freezing holes at the release chambers. After the tumor tissue is drawn into the sampling slot under negative pressure, the refrigerant freezes the tumor tissue through the freezing holes, causing it to lose its original biological elasticity and be firmly fixed in the sampling slot. Then, the tissue is rotary-cut by the inner cutting blade. Since the tissue loses its elasticity, it can be effectively removed, thereby improving the sampling efficiency.

[0033] 2. In the existing technology, patients usually feel the discomfort of physical traction during the negative pressure adsorption of tumor tissue. In one embodiment of the present invention, the adsorbed tissue is frozen at the moment of vacuum adsorption. Since the human body is not sensitive to cold, it will produce a certain freezing analgesia effect on the surgical site, improve the patient's tolerance to the rotary excision surgery, and has extremely high clinical application value. Attached Figure Description

[0034] Figure 1 This is a schematic diagram of the low-temperature freezing rotary cutting device of the present invention;

[0035] Figure 2 This is a cross-sectional view of the cryogenic rotary cutting apparatus of the present invention;

[0036] Figure 3 The low-temperature freezing rotary cutting device of the present invention is in Figure 1 A-direction cross-section view;

[0037] Figure 4 The low-temperature freezing rotary cutting device of the present invention is in Figure 1 Sectional view in direction B;

[0038] Figure 5 The low-temperature cryogenic rotary cutting device of the present invention Figure 2 Enlarged cross-sectional view;

[0039] Figure 6 This is an enlarged cross-sectional view of the air inlet pipe of the cryogenic rotary cutting device of the present invention.

[0040] Explanation of reference numerals in the attached drawings: 1: Puncture tip; 110: Tail protrusion; 2: Sample groove; 21: Tail sealing surface; 3: Fixing sleeve; 31: Sleeve installation groove; 32: Inner tube opening; 33: Refrigerant slot; 34: Refrigerant inlet hole; 4: Inner tube; 41: Inner cutting blade; 42: Tail end of inner tube; 5: Outer sleeve; 52: Groove; 53: Base; 6: Inner sleeve; 7: Sealing structure; 8: Air inlet chamber; 9: Air inlet pipe; 91: Freezing hole; 92: Filler; 93: Air inlet pipe interface; 94: Tail end of air inlet pipe interface; 10: Sealing opening; 11: Release chamber; 12: End cap. Detailed Implementation

[0041] The following detailed description, in conjunction with the accompanying drawings and specific embodiments, provides a cryogenic rotary cutting device according to the present invention. The advantages and features of the present invention will become clearer from the following description and claims.

[0042] See Figures 1 to 6 In one embodiment, a cryogenic slicing device includes a fixing element, an inner sleeve 6, an outer sleeve 5, a sealing structure 7, an air inlet structure, and an inner tube 4.

[0043] The fixing component has an inner tube opening 32. The tail end of the inner sleeve 6 is fixed to the fixing component, and the hollow inner cavity of the inner sleeve 6 and the inner tube opening 32 cooperate to form a rotary cutting cavity. The tail end of the outer sleeve 5 is fixed to the fixing component and sleeved on the inner sleeve 6. The head end of the outer sleeve 5 is provided with a puncture tip 1, and the tail protrusion 110 of the puncture tip 1 is coaxially sleeved on the outer sleeve 5.

[0044] The side facing the puncture tip 1 is defined as the head end, and the side away from the puncture tip 1 is defined as the tail end.

[0045] The gap between the outer sleeve 5 and the inner sleeve forms an annular intermediate cavity. A sampling groove is radially formed near the beginning of both the inner sleeve 6 and the outer sleeve 5. This sampling groove connects to the rotary cutting cavity and extends through part of the intermediate cavity. The plane at the end of the sampling groove, perpendicular to the axis, divides the intermediate cavity into two chambers: a freezing chamber near the puncture tip 1 and an air intake chamber 8 away from the puncture tip 1.

[0046] The sealing structure 7 is located in the freezing chamber, and at least one release chamber 11 is provided in the sealing structure 7 to communicate with the air inlet chamber 8. The inner sleeve 6 is provided with at least one row of freezing holes 91 to communicate with the sampling groove and the corresponding release chamber 11.

[0047] The intake structure is configured to penetrate into the intake chamber 8 between the outer sleeve 5 and the inner sleeve 6, and the output end of the intake structure is connected to the corresponding release chamber 11 via the intake chamber 8. The input end of the intake structure can be connected to the external refrigerant supply end for delivering high-pressure refrigerant to the release chamber 11.

[0048] The inner tube 4 is designed to extend into and be movably connected to the rotary cutting cavity. The first end of the inner tube 4 is provided with an inner cutting blade 41, and the tail end of the inner tube 4 is used to connect to the negative pressure end of the main unit. That is, the inner tube 4 can rotate and move back and forth within the inner sleeve 6. By moving back and forth and rotating, it can be extended into the sampling slot to complete the rotary cutting of tumor tissue.

[0049] After being positioned at the target location, the target object is drawn in by the negative pressure formed by the rotary cutting cavity and the external negative pressure device in the sampling tank. The refrigerant enters the sampling tank through the air intake structure, release chamber 11 and freezing hole 91 to freeze the target object. After freezing is completed, the inner tube 4 and the inner cutting blade 41 rotate forward along the axial direction to cut and separate the target object into the sampling tank.

[0050] In this embodiment, an outer sleeve 5, an inner sleeve 6, and an inner tube 4 are sequentially arranged from the outside to the inside. The inner tube 4 passes through the fixing member and the inner sleeve 6, and its first end is provided with an inner cutting blade 41. The first end of the outer sleeve 5 is provided with a piercing tip 1. The tail ends of the outer sleeve 5 and the inner sleeve 6 are fixed to the fixing member, forming an intermediate cavity between them for the air intake structure to enter. Sampling slots are opened near the first ends of the outer sleeve 5 and the inner sleeve 6. A sealing structure 7 is provided at the intermediate cavity corresponding to the sampling slot, forming several release chambers 11 and an air intake chamber 8 connected to them. The air intake structure is configured to provide refrigerant to the corresponding release chamber 11 through the air intake chamber 8. The inner sleeve 6 is provided with a corresponding freezing hole 91 at the release chamber 11. After the tumor tissue is drawn into the sampling tank under negative pressure, the refrigerant freezes the tumor tissue through the freezing hole 91, causing it to lose its original biological elasticity and be firmly fixed in the sampling tank. Then, the tissue is rotary cut by the inner cutting blade 41. Since the tissue loses its elasticity, it can be effectively removed, thereby improving the sampling efficiency.

[0051] Furthermore, this embodiment freezes the aspirated tissue at the moment of vacuum adsorption. Since the human body is not sensitive to cold, it will produce a certain cryo-analgesic effect on the surgical site, thereby improving the patient's tolerance to the excision procedure and having extremely high clinical application value.

[0052] The specific structure of the low-temperature freezing rotary cutting device in this embodiment will be further described below:

[0053] In this embodiment, in order to enable the air intake structure to be inserted, the outer sleeve 5 is provided with a connection interface that communicates with its inner cavity. Specifically, it can be a slot 52 opened at the tail end of the outer sleeve 5 and a base 53 located on the outer periphery of the slot 52. The base 53 is provided with a through hole that communicates with the slot 52.

[0054] See Figure 6 The intake structure includes at least one intake pipe 9 and an intake pipe interface 93. The first end of the intake pipe interface 93 is embedded in the base 53 and sealed to a through hole within the base 53. The tail end of the intake pipe 9 is fixed to a fastener for connection to an external refrigerant supply unit. All intake pipes 9 are arranged in the intake chamber 8. The first end of the intake pipe 9 extends into the corresponding release chamber 11. The tail end of the intake pipe 9 is sealed to the through hole of the base 53. The sealing can be achieved by filling and sealing with a filler 92. The tail end of the intake pipe 9 connects to the inner cavity of the intake pipe interface 93, allowing refrigerant to enter the intake pipe 9 through the intake pipe interface 93.

[0055] See Figure 4 In this embodiment, the portion of the sealing structure 7 at the tail end of the sampling groove is defined as the tail end sealing surface 21. The sealing structure 7 at the tail end sealing surface 21 has at least one sealing opening 10 that communicates one-to-one with the release chamber 11. The first end of the air inlet pipe 9 extends into and is sealed to the sealing opening 10. The purpose of setting the sealing opening 10 here is to isolate the release chamber 11 from the air inlet chamber 8 and prevent the refrigerant in the release chamber 11 from entering the air inlet chamber 8 and causing leakage.

[0056] In this embodiment, the smaller the diameter of the intake pipe 9, the better the cooling effect when the refrigerant is injected from the freezing hole 91. The size and number of freezing holes 91 can be designed arbitrarily, as long as the diameter of the freezing hole 91 is smaller than the inner diameter of the intake pipe 9.

[0057] In this embodiment, in order to ensure uniform freezing of tumor tissue, a number of release cavities 11 can be arranged to be distributed circumferentially in the freezing chamber, and the number can be four or other.

[0058] In this embodiment, in order to ensure accurate freezing of the aspirated tumor tissue, the diameter direction of the freezing hole 91 is the diameter direction of the inner sleeve 6 where it is located, so as to spray vertically onto the tumor tissue; in each row of freezing holes 91, each freezing hole 91 can be configured to be arranged axially on the inner sleeve 6 at uniform intervals.

[0059] See Figure 2 In this embodiment, the fixing member can be a fixing sleeve 3, which is provided with an inner tube opening 32 for the inner tube 4 to pass through, and a refrigerant slot 33 and a refrigerant inflow hole 34 that are connected.

[0060] The fixed sleeve 3 is provided with a sleeve mounting groove 31 concentric with the inner tube opening 32. The tail ends of the inner sleeve 6 and the outer sleeve 5 are respectively sealed and connected to the sleeve mounting groove 31 by end caps 12. The diameters of the outer sleeve 5 and the inner sleeve 6, as well as the gap between them, can be designed in various combinations, as long as the intake pipe 9 can pass through. The tail end 94 of the intake pipe interface is inserted into and sealed to the refrigerant slot 33, and the refrigerant inlet hole 34 is used to connect to the external refrigerant supply end.

[0061] In this embodiment, the refrigerant is any refrigerant that can generate a temperature difference using the Joule-Thomson effect, including CO2, N2O, etc. The storage form of the refrigerant can be a pressurized gas cylinder (external refrigerant supply end), etc.

[0062] In this embodiment, the diameter of the inner tube 4 at the inner cutting blade 41 is equal to or slightly smaller than the inner diameter of the outer sleeve 5. This tight fit will allow the inner cutting blade 41 to completely remove abnormal breast tissue without trapping the tissue in the gap between the two.

[0063] In this embodiment, the shape of the puncture tip 1 and the inner cutting blade 41 can be in various forms, as long as it ensures successful puncture to the location of the breast tumor.

[0064] In this embodiment, the cryogenic rotary cutting device may further include a dynamic sealing structure 7, disposed between the inner tube opening 32 and the inner tube 4, for sealing the inter-tube gap between the inner tube opening 32 and the inner tube 4 in a first structural state, so that the inter-tube gap is not connected to the external atmosphere, and in a second structural state, connecting the inter-tube gap to the external atmosphere. Specifically, the dynamic sealing structure 7 may include a sealing ring disposed at the inner tube opening 32 and a connecting structure disposed at the tail end 42 of the inner tube. When the inner tube 4 and the inner cutting blade 41 are not in the sampling groove, the sealing ring contacts the outer wall surface of the inner tube 4 to achieve a seal; when the inner tube 4 and the inner cutting blade 41 enter the sampling groove for rotary cutting, as the inner tube 4 moves forward, the connecting structure on it contacts the sealing ring, thereby releasing the seal at the connecting structure.

[0065] All of the above-mentioned sealing connection methods can be adhesive bonding, welding, tight fitting, or any other form that can serve to fix and seal the connection.

[0066] Example 2

[0067] This embodiment provides a rotary cutting system for breast tumor diagnosis, including the low-temperature cryogenic rotary cutting device described in Embodiment 1 above. It consists of an outer sleeve 5, an inner sleeve 6, and an inner tube 4, arranged sequentially from the outside in. The inner tube 4 passes through a fixing member and the inner sleeve 6, with an inner cutting blade 41 at its first end. The first end of the outer sleeve 5 is provided with a puncture tip 1. The tail ends of the outer sleeve 5 and the inner sleeve 6 are fixed to the fixing member, forming an intermediate cavity between them for the air intake structure to enter. Sampling slots are provided near the first ends of the outer sleeve 5 and the inner sleeve 6. A sealing structure 7 is provided at the intermediate cavity corresponding to the sampling slot, forming several release chambers 11 and an air intake chamber 8 connected to them. The air intake structure is configured to provide refrigerant to the corresponding release chamber 11 via the air intake chamber 8. The inner sleeve 6 has corresponding freezing holes 91 at the release chambers 11. After the tumor tissue is drawn into the sampling tank under negative pressure, the refrigerant freezes the tumor tissue through the freezing hole 91, causing it to lose its original biological elasticity and be firmly fixed in the sampling tank. Then, the tissue is rotary cut by the inner cutting blade 41. Since the tissue loses its elasticity, it can be effectively removed, thereby improving the sampling efficiency.

[0068] The specific surgical procedure of the cryogenic rotary cutting device in this embodiment is described below:

[0069] During the sampling procedure, when tumor tissue is drawn into sample slot 2 by negative pressure along the inner lumen of inner tube 4, pressurized refrigerant is injected into the air intake structure through the main unit pipeline and ejected through freezing hole 91. The cooled refrigerant is ultimately sprayed onto the tumor tissue drawn into sample slot 2. Due to the Joule-Thomson effect, the refrigerant released through throttling generates low temperatures, instantly freezing the tumor tissue to below zero degrees Celsius. The tumor tissue, having lost its original biological elasticity, is easily removed by the inner cutting blade 41 at the head of inner tube 4 and then transported by the system under negative pressure to the sample collection chamber. Thus, one cycle of sampling procedure is completed. Since the refrigerant can only be sprayed towards the drawn-in tissue, the cold energy is only transferred to the drawn-in tissue, while the undrawn tissue retains its original biological elasticity. With the end face of sample slot 2 as the boundary, the tissue is divided into frozen and unfrozen parts, which have completely different biological properties at the interface. As the inner cutting blade 41 rotates forward at high speed along its axis, it easily separates the two parts, greatly improving cutting efficiency. Furthermore, the tissue sprayed with refrigerant loses its biological elasticity and is firmly fixed in the sample slot 2, providing further assistance for cutting. The refrigerant sprayed through the freezing port 91 is then transported by the system's negative pressure along with the removed tissue to the sample collection chamber connected at the rear end, and finally reaches the main unit's return gas collection chamber before being discharged from the system.

[0070] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings, but the present invention is not limited to the above embodiments. Even if various changes are made to the present invention, if these changes fall within the scope of the claims of the present invention and their equivalents, they shall still fall within the protection scope of the present invention.

Claims

1. A low-temperature freezing rotary cutting device, characterized in that, include: The fastener has an inner tube opening. An inner sleeve is fixed to the fixing member, and the hollow inner cavity of the inner sleeve and the opening of the inner tube cooperate to form a rotary-cut cavity; An outer sleeve is fixed to the fixing member and sleeved on the inner sleeve. The first end of the outer sleeve is provided with a puncture tip, and the side facing the puncture tip is defined as the first end, and the side away from the puncture tip is defined as the tail end. An intermediate cavity is formed between the outer sleeve and the inner sleeve. Sampling grooves are radially formed on the inner sleeve and the outer sleeve, which communicate with the rotary cutting cavity and penetrate part of the intermediate cavity. The plane at the tail end of the sampling groove and perpendicular to the axis divides the intermediate cavity into a freezing chamber near the puncture tip and an air inlet chamber away from the puncture tip. A sealing structure is provided inside the freezing chamber, and at least one release chamber is provided inside the sealing structure to communicate with the air inlet chamber; wherein, the inner sleeve is provided with at least one row of freezing holes to communicate with the sampling groove and the corresponding release chamber; An intake structure is inserted into the outer sleeve, and the output end of the intake structure is connected to the corresponding release chamber via the intake chamber for delivering refrigerant to the release chamber. An inner tube extends into and is movably connected to the rotary cutting cavity. The first end of the inner tube is provided with an inner cutting blade, and the tail end of the inner tube is used to connect to the negative pressure end of the main unit. After being positioned at the target location, the sampling slot forms a negative pressure with the negative pressure end of the host through the rotary cutting cavity to draw in the target object. The refrigerant enters the sampling slot through the air intake structure, the release chamber and the freezing hole to freeze the target object. After freezing is completed, the inner tube and the inner cutting blade rotate forward along the axial direction to cut and separate the target object into the sampling slot. It also includes a dynamic sealing structure disposed between the inner tube opening and the inner tube, used to seal the gap between the inner tube opening and the inner tube when the inner tube does not enter the sampling groove, so that the gap between the tubes is not connected to the outside atmosphere, and to connect the gap between the tubes and the outside atmosphere when the inner tube enters the sampling groove.

2. The low-temperature freezing rotary cutting device as described in claim 1, characterized in that, The outer sleeve is provided with a connection interface that communicates with its inner cavity; The air intake structure includes at least one air intake pipe and an air intake pipe interface; The first end of the intake pipe interface is sealed and connected to the connection interface, and the tail end of the intake pipe is fixed to the fixing member for connection with the external refrigerant supply unit. The intake pipes are all arranged in the intake chamber; the first end of the intake pipe extends into the corresponding release chamber; the tail end of the intake pipe is sealed and connected to the connection interface and communicates with the inner cavity of the intake pipe interface.

3. The low-temperature freezing rotary cutting device as described in claim 2, characterized in that, The portion of the sealing structure at the tail end of the sampling groove is the tail end sealing surface; At least one sealing opening is provided on the tail end sealing surface, which is connected to the release chamber in a one-to-one manner, and the first end of the air intake pipe extends into and is sealed to the sealing opening.

4. The low-temperature freezing rotary cutting device as described in claim 2, characterized in that, The diameter of the freezing hole is smaller than the inner diameter of the air inlet pipe.

5. The low-temperature freezing rotary cutting device as described in claim 1, characterized in that, Several of the release chambers are distributed circumferentially in the freezing chamber.

6. The low-temperature freezing rotary cutting apparatus as described in claim 1, characterized in that, The diameter direction of the freezing hole is the diameter direction of the inner sleeve where it is located.

7. The low-temperature freezing rotary cutting device as described in claim 1, characterized in that, The refrigerant is CO2 or N2O.

8. The low-temperature freezing rotary cutting device as described in claim 2, characterized in that, The fixing component is a fixing sleeve, which has an inner tube opening for the inner tube to pass through, as well as a refrigerant slot and a refrigerant inlet hole. The fixed sleeve is provided with a sleeve mounting groove concentric with the opening of the inner tube, and the tail ends of the inner sleeve and the outer sleeve are respectively sealed and connected in the sleeve mounting groove. The tail end of the air intake pipe interface is sealed to the refrigerant slot hole, and the refrigerant inlet hole is used to connect to the external refrigerant supply end.

9. The low-temperature freezing rotary cutting device as described in claim 1, characterized in that, The outer diameter of the inner cutting edge is less than or equal to the inner diameter of the inner sleeve.