A kind of five-flavor diuretic and swelling-removing powder and its preparation method and application

Abstract

The invention discloses a five-flavor diuretic and swelling-removing powder and a preparation method and application thereof. The five-flavor diuretic and swelling-removing powder comprises, by weight, 80 to 150 parts of red beans, 10 to 30 parts of gardenia, 5 to 15 parts of sodium sulfate, 1 to 5 parts of borneol, and 1 to 5 parts of rhubarb. In the invention, the five-flavor medicines can be combined to achieve the effects of clearing heat and cooling blood, promoting diuresis and reducing swelling, and relieving pain. The medicine can be applied externally to the affected part and can be used for patients with acute soft tissue sprains and contusions and effusion. It is particularly suitable for common clinical conditions such as fracture edema and postoperative edema in orthopedics. The five-flavor diuretic and swelling-removing powder is simple to prepare and has the advantages of being easy to carry, saving medicinal materials, and not easy to deteriorate.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine compositions, and in particular to a five-flavor diuretic and swelling-removing powder and a preparation method and application thereof. Background Art

[0002] Knee arthroscopy is a good treatment for early KOA. It can be diagnosed and treated with the help of arthroscopy. It has the characteristics of less trauma, faster recovery, and fewer complications. With the continuous increase and expansion of the number and scope of knee arthroscopy, postoperative complications have become a key issue in clinical practice. Postoperative swelling is one of the common complications after knee arthroscopy. Since post-arthroscopic swelling is not a serious complication and is partially self-healing, it is often ignored in clinical practice. However, postoperative swelling and pain seriously affect patients' rehabilitation exercises and quality of life, prolong hospitalization, and cause additional economic burden. At the same time, the swelling caused by joint hematoma and effusion is not treated, which will lead to other lesions such as intra-articular synovitis, aggravating the swelling and forming a vicious circle.

[0003] At present, it is generally believed that the factors causing postoperative swelling at home and abroad are mainly as follows: 1. Hematoarthritis is the most common cause of swelling after arthroscopy, which is mostly caused by rough operation during surgery, damage to fat pads, ineffective hemostasis during surgery, failure to perform local bandaging after surgery, and failure to remove hematoma as soon as possible. 2. Joint effusion: During arthroscopy, a large amount of saline is used to flush and expand the joint cavity; the saline is absorbed by the nearby soft tissue cells and causes swelling; it is a reaction after the synovial membrane of the joint is stimulated. 3. Intraoperative operation injury: surgical trauma causes damage to capillaries around the knee joint, dilation and congestion, resulting in increased permeability of the vascular wall, and extravasation of intravascular fluid into the tissue space, causing local swelling. 4. The microenvironment of the knee joint changes in the early postoperative period. After the synovial membrane of the knee joint is stimulated, a sterile inflammatory reaction is produced, resulting in congestion of the synovial tissue, increased permeability of the vascular wall, and increased exudation. 5. The metabolism of body tissues is significantly accelerated after surgery, and the metabolic process of sugar, lipids and proteins produces a large amount of endogenous water, which can cause water retention in the patient's body. In addition, traction and blunt dissection of soft tissue during surgery and reactive swelling of soft tissue after surgery may further aggravate swelling.

[0004] Cold therapy and elastic bandage pressure dressing are currently the most commonly used methods for treating and preventing postoperative swelling in clinical practice; ice compress uses the human body's physiological response to cold, which causes capillary contraction and reduced microvascular permeability, thereby reducing local tissue congestion and swelling. The temperature of local skin, subcutaneous, and muscle tissues decreases, stimulating the skin temperature receptors, causing vasoconstriction through local sympathetic reactions, reducing peripheral blood flow, reducing oxygen consumption, and helping to reduce oozing, bleeding, and the release of inflammatory factors such as histamine, inhibiting vascular permeability, and reducing patient edema. Researchers have combined cold therapy and elastic bandage dressing after arthroscopic surgery for meniscus injury, synovitis, and loose bodies in the knee joint, which can effectively reduce bleeding and joint swelling. In terms of drugs, Western medicine treatment is mainly based on drugs such as mannitol, glycerol fructose, hormones, and sodium aescinate (traditional Chinese medicine extract) that dehydrate and inhibit inflammatory exudation. However, Western medicine is mostly limited to symptomatic treatment, and the factors that cause swelling after knee arthroscopy are diverse in clinical practice, and a single treatment method cannot achieve good clinical efficacy.

[0005] Traditional Chinese medicine believes that blood overflows from the meridians and blood stagnates, which causes blood stasis. The obstruction of the flow of qi and blood can cause water to stagnate locally and form water retention. The stasis of blood and water retention is the pathological basis for local pain and swelling. "Clinical Guide Medical Cases·Bi" points out that "external evils remain, qi and blood are injured, and they turn into stagnation and phlegm, which mix with the meridians", indicating that surgical injuries to the tendons and veins of the limbs lead to local qi disorder, which is the pathological basis for the generation of stasis of blood and water retention. "Medical Anthology Golden Mirror" says: "Human qi and blood circulate constantly, and swelling occurs when there is a slight stagnation." Traditional Chinese medicine believes that a person is an organic whole, and qi, blood, and body fluids flow throughout the body, circulate endlessly, and cannot travel. During the arthroscopy of synovial plica syndrome, soft tissue release and damage damage the meridians. If the meridians are not running smoothly, qi stagnates and blood coagulates in the meridians, and the meridians are blocked. If the body is qi-deficient and the meridians are blocked, water and moisture cannot flow, and the limbs swell. The Treatise on Blood Evidence states: "For those who have not broken the skin, their blood will be damaged, and if their muscles are injured, they will swell and ache... When blood stasis turns into water, it will also cause edema." Therefore, local swelling in the early postoperative period is mostly due to qi stagnation and blood stasis, stasis and water stasis, and water and dampness blocking the body. It is advisable to remove the stasis and generate new blood, so that the qi can flow smoothly, and achieve the effect of relaxing muscles and relieving pain. The Yellow Emperor's Classic of Internal Medicine states: "All diseases, swelling, pain, soreness and shock are all related to fire." Therefore, the treatment of swelling and pain is mainly based on clearing heat and cooling blood, promoting blood circulation and promoting water excretion. However, in clinical practice, Taohong Siwu Decoction, Xuefu Zhuyu Decoction and other blood-activating prescriptions are often used to improve postoperative edema, but the syndrome differentiation is unclear, the medication is not accurate, and the targeting is not strong, so the effect is not ideal. Summary of the invention

[0006] The present invention aims to solve at least one of the above-mentioned technical problems existing in the prior art. To this end, the object of the present invention is to provide a Wuwei Lishui Xiaozhong powder and a preparation method and application thereof.

[0007] In order to achieve the above object, the technical solution adopted by the present invention is:

[0008] According to the first aspect of the present invention, a Wuwei Lishui Xiaozhong powder is provided, which comprises 80-150 parts of red beans, 10-30 parts of gardenias, 5-15 parts of sodium sulfate, 1-5 parts of borneol, and 1-5 parts of rhubarb in parts by weight.

[0009] In some embodiments of the present invention, Wuwei Lishui Xiaozhong Powder includes, by weight, 100-130 parts of red beans, 15-26 parts of gardenias, 8-13 parts of sodium sulfate, 2-5 parts of borneol, and 1-4 parts of rhubarb.

[0010] In some embodiments of the present invention, the Wuwei Lishui Xiaozhong Powder includes, by weight, 80-150 parts of red beans, 20 parts of gardenia, 10 parts of sodium sulfate, 3 parts of borneol, and 2 parts of rhubarb.

[0011] In some embodiments of the present invention, the dosage form of the Wuwei Lishui Xiaozhong Powder includes any one of a powder, an ointment, and a patch.

[0012] According to a second aspect of the present invention, a preparation method of the Wuwei Lishui Xiaozhong Powder is proposed, comprising the following steps: grinding adzuki bean, gardenia, sodium sulfate, borneol and rhubarb according to weight portions, and mixing them to obtain a powder.

[0013] In some embodiments of the present invention, the preparation method of the Wuwei Lishui Xiaozhong Powder further comprises mixing and stirring the medicinal powder with water; preferably, the mass volume ratio of the medicinal powder to the water is 100:(10-40) g / mL; preferably 100:(20-30) g / mL; preferably 100:25 g / mL.

[0014] According to a third aspect of the present invention, a use of the Wuwei Lishui Xiaozhong Powder in the preparation of a medicine for treating sprains, fracture swelling and / or orthopedic postoperative swelling is proposed.

[0015] In some embodiments of the present invention, the orthopedic post-operative swelling comprises knee post-operative swelling.

[0016] The beneficial effects of the present invention are:

[0017] (1) In the present invention, the combination of the five herbs can clear away heat and cool blood, promote diuresis and reduce swelling, and relieve pain. This medicine can be applied to the affected area for patients with acute soft tissue sprains and contusions and effusion. It is particularly suitable for common clinical conditions such as fracture edema and postoperative edema in orthopedics.

[0018] (2) The Wuwei Lishui Xiaozhong Powder of the present invention is simple to prepare, easy to carry, saves medicinal materials, and is not easy to deteriorate.

[0019] (3) The raw materials of the Wuwei Lishui Xiaozhong Powder of the present invention are cheap, with an average daily cost of about 6.2 yuan. Taking sodium aescinate, a commonly used clinical drug for patients with edema after orthopedic surgery, as an example, its average daily cost is about 34 yuan, which is more than 5 times the price of the Wuwei Lishui Xiaozhong Powder of the present invention.

[0020] Specifically:

[0021] Wu Shiji of the Qing Dynasty proposed: "The principle of external treatment is the same as the principle of internal treatment; the medicine for external treatment is the same as the medicine for internal treatment. The only difference is the method." Therefore, for secondary lymphedema of the limbs, Professor Wang Qingguo, based on the theory of "Huangdi Neijing": "All diseases, swelling, pain, soreness and shock are all related to fire", advocates the use of external application methods of clearing heat and cooling blood, promoting diuresis and reducing swelling to treat local edema directly to the site of the disease.

[0022] The red bean in the formula is sweet, sour and neutral in nature. It enters the small intestine and bladder meridians. It has the functions of detoxification, pus discharge, diuresis and swelling. In the "Compendium of Materia Medica", it is recorded that "it is mainly used to discharge pus and blood from carbuncle. It tastes sweet and sour, is neutral and warm, non-toxic, and can cure cold and heat, relieve thirst and diarrhea in heat, promote urination, vomiting, and relieve bloating." It can not only promote diuresis and swelling, but also activate blood circulation and remove blood stasis, so that the meridians can be unblocked and water and moisture can be removed. It is the main medicine of this prescription.

[0023] Gardenia is bitter and cold, and enters the heart, liver, lung, stomach, and triple burner meridians. It is good at clearing away stagnant heat, relieving depression and relieving restlessness. It can also guide fire downward, descending without rising. External use can reduce swelling and relieve pain. "Compendium of Materia Medica" Volume 2 says: "It can relieve the evil heat of the heart and lungs, make it bend downward and come out through urine, and the stagnant fire in the triple burner will be relieved." It has a very good effect on redness and swelling, especially for patients with acute injuries.

[0024] Glauber's salt is bitter and cold in nature. It enters the small intestine and triple burner meridians. It can purge and relieve constipation, moisturize dryness and soften hard masses, clear away heat and reduce swelling. "Compendium of Materia Medica" says: "Glauber's salt is produced by the extreme coldness of heaven and earth, so it tastes bitter and pungent, and is very cold in nature. It is the essence of Taiyin. Its nature is to digest things... Long-term fever is evil heat. The heat evil of typhoid fever accumulates in the middle burner, or the stomach is bloated and blocked when drinking or eating. A small amount of it can be taken and it can be eliminated immediately. The evil qi can be eliminated because cold can eliminate heat. The retained blood can be broken because salt can soften hard masses and pungent can disperse the knots. When the evil heat is strong, the meridians are blocked, and the heat is rampant inside. It can be treated with salty and cold. The knots are dispersed and the heat is eliminated, and the meridians will be unblocked." It can not only purge fire and reduce burning and steaming, but also promote diuresis and relieve dripping, and can dissipate the local hardness of edema. "

[0025] Rhubarb is bitter and cold in nature. It enters the spleen, stomach, large intestine, liver, and pericardium meridians. It can purge and attack stagnation, clear away heat and purge fire, cool blood and detoxify, remove blood stasis and dredge menstruation, and relieve dampness and jaundice. The New Compendium of Materia Medica says: "Rhubarb is very fast in nature, it moves but does not stay, it is good at clearing stagnation, regulating the middle and digesting food, promoting the flow of water and food, removing the old and bringing in the new, guiding blood stasis, rolling away phlegm, breaking up knots, dispersing hard masses, relieving pain, defeating carbuncle heat toxins, and reducing swelling, all of which are magical." Here, rhubarb is added to activate blood circulation, remove stagnation, and achieve the effect of removing the old and bringing in the new.

[0026] Borneol is pungent and cool in nature, and belongs to the liver and lung meridians. It can open the mind, clear away heat and relieve pain. It has a good running effect, can open the meridians, and form a tendency of permeation. Modern pharmacological studies have shown that borneol can promote the passage of drugs through the blood-brain barrier, mucosa, gastrointestinal tract, skin and other parts by inhibiting the function of transporter pumps, regulating the level of biochemical substances, changing the structural changes of the stratum corneum of the skin, and loosening the tight junction structure of endothelial cells, thereby playing a role in guiding the meridians. While following the principle of syndrome differentiation and treatment, external Chinese medicine is combined with pungent and fragrant running products to promote the conduction of drugs through meridians and skin penetration, so as to achieve the purpose of curing diseases.

[0027] "Wuwei Lishui Xiaozhong San" is derived from the clinical prescription of Professor Wang Qingguo, a master of traditional Chinese medicine. Professor Wang Qingguo is the fifth batch of national senior Chinese medicine experts and academic experience inheritance instructor. He studied under Mr. Liu Duzhou, a master of classical prescriptions. He studied typhoid fever and combined various schools. He has been practicing medicine for more than 50 years and has rich clinical experience. The original prescription of this product is the clinical experience prescription used by Professor Wang Qingguo and Teacher Gao Fei to treat sprains, fractures or soft tissue edema after minimally invasive orthopedic surgery. It is based on the "Inner Canon of Medicine" and has significant efficacy and positive results.

[0028] At present, Western medicine mostly uses oral or injectable drugs for secondary lymphedema caused by sprains, fractures or surgical operations. Although Western medicine has a definite effect, it has many adverse reactions and side effects. Taking sodium aescinate commonly used in orthopedic clinics as an example, some patients may experience side effects such as nausea, vomiting, and diarrhea after taking the drug. This drug is nephrotoxic. It is generally recommended that each treatment cycle should not exceed 7 to 10 days. If this drug is used in large doses, there may be a risk of acute tubular necrosis and decreased glomerular filtration rate. Patients may experience oliguria or anuria. Traditional medicine has few toxic and side effects and few adverse reactions. The main ingredients of this product are all natural Chinese herbal medicines, the taste of the medicine is simple, and the constituent drugs are non-toxic, mild and non-irritating. At the same time, this product is derived from the clinical prescription of Professor Wang Qingguo, a master of traditional Chinese medicine. No adverse reactions have been seen in the clinic, and there are no cases of sensitization, which fully demonstrates the safety and reliability of this product. In addition, the efficacy of local transdermal absorption of traditional Chinese medicine external treatment has obvious advantages over oral and injectable drugs in special diseases. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 The diagram shows the state of Xiaozhongsan before (a) and after (b) preparation in Test Example 1 of the present invention.

[0030] Figure 2 This is the method for using the Xiaozhong Powder in Test Example 1 of the present invention.

[0031] Figure 3 This is the method for using the Xiaozhong Powder in Test Example 1 of the present invention.

[0032] Figure 4 This is a picture of the affected area of ​​the patient before medication in Test Example 1 of the present invention.

[0033] Figure 5 This is a picture of the affected area of ​​the patient in Test Example 1 of the present invention after applying Wuwei Lishui Xiaozhong Powder of Example 1 for one day. DETAILED DESCRIPTION

[0034] The present invention is further described in detail below by specific examples. Unless otherwise specified, the raw materials, reagents or devices used in the examples and comparative examples can be obtained from conventional commercial sources or can be obtained by prior art methods. Unless otherwise specified, the experiments or test methods are conventional methods in the art.

[0035] Example 1

[0036] This example prepares a Wuwei Lishui Xiaozhong powder, and the specific process is as follows:

[0037] In terms of weight, prepare 100 parts of red beans, 10 parts of Glauber's salt, 3 parts of borneol, 20 parts of gardenia, and 2 parts of rhubarb. Dry the five Chinese medicines, grind them into powder with a wall breaking machine, mix them evenly, and prepare Wuwei Lishui Xiaozhong Powder. Weigh 100g of each and package them in a bag.

[0038] Example 2

[0039] This example prepares a Wuwei Lishui Xiaozhong powder, and the specific process is as follows:

[0040] In terms of weight, prepare 120 parts of red beans, 8 parts of Glauber's salt, 5 parts of borneol, 25 parts of gardenias, and 1 part of rhubarb. Dry the five Chinese medicines, grind them into powder with a wall breaking machine, mix them evenly, and prepare Wuwei Lishui Xiaozhong Powder. Weigh 100g of each and package them in a bag.

[0041] Example 3

[0042] This example prepares a Wuwei Lishui Xiaozhong powder, and the specific process is as follows:

[0043] In terms of weight, prepare 110 parts of red bean, 6 parts of Glauber's salt, 3 parts of borneol, 30 parts of gardenia, and 3 parts of rhubarb. Dry the five Chinese medicines, grind them into powder with a wall breaking machine, mix them evenly, and prepare Wuwei Lishui Xiaozhong Powder. Weigh 100g of each and package them in a bag.

[0044] Comparative Example 1

[0045] This comparative example prepares a detumescence powder, which differs from Example 1 in that it does not include mirabilite. The specific process is as follows:

[0046] In terms of weight, prepare 100 parts of red beans, 3 parts of borneol, 20 parts of gardenias, and 2 parts of rhubarb. Dry the four Chinese medicines, grind them into powder using a wall breaking machine, mix them evenly, and prepare Xiaozhong powder. Weigh each 100 g into a bag and package them.

[0047] Comparative Example 2

[0048] This comparative example prepares a detumescence powder, which differs from Example 1 in that it does not include red beans. The specific process is as follows:

[0049] In terms of weight, prepare 10 parts of Glauber's salt, 3 parts of borneol, 20 parts of gardenia, and 2 parts of rhubarb. Dry the four Chinese medicines, grind them into powder using a wall breaking machine, mix them evenly, and prepare Xiaozhong powder. Weigh 100 g of each and package them in a bag.

[0050] Test Example 1

[0051] This test example evaluates the efficacy of Wuwei Lishui Xiaozhong Powder prepared in Example 1, and the specific process is as follows:

[0052] The degree of edema needs to be measured before applying the medicine. The specific process is as follows:

[0053] Lower limb edema: Measure the longest part of the patient's calf circumference and 10cm above the patella. Center on the ankle, 10cm above the medial malleolus, and a circle at the widest part of the sole. Compare both sides.

[0054] Measurement method:

[0055] 1. Mark the position of the patella.

[0056] 2. Measure the calf circumference: The patient lies on his back with his knees bent and his feet flat on the bed. Use a tape measure to measure the calf circumference 10 cm below the lower edge of the patella.

[0057] 3. Measure thigh circumference: The patient lies on his back with the thigh muscles relaxed. Measure the thigh circumference 10 cm above the patella from the upper edge of the patella to the thigh.

[0058] 4. If there is muscle atrophy or swelling, measure the circumference on the plane where it is most obvious.

[0059] Note:

[0060] 1. The circumference is recorded accurately to 0.1cm.

[0061] 2. After determining the measurement starting point, objectively measure the limb circumference. When measuring, the tape measure should be of appropriate tightness so as not to squeeze the skin. It should not be too loose or too tight.

[0062] 3. If the difference in circumference between the two lower limbs is greater than 1 cm or the circumference at the same point on the same side increases by 1 cm, it is considered to be clinically significant.

[0063] According to the above measurement standards, the efficacy of medication was recorded in 34 patients (18 males and 26 females) with clinically significant edema after knee arthroscopy.

[0064] How to use: Figure 1 As shown, take the Wuwei Lishui Xiaozhong Powder prepared in Example 1, add 25mL of purified water to every 100g of powder (1 bag), and stir until it becomes a paste ( Figure 1 (b)). Adjust the dosage according to the fatness or thinness of the edema patient, and spread the prepared paste powder on four layers of gauze (such as Figure 2 As shown), cover with a layer of gauze (as Figure 3 Apply to the affected area twice a day for 1 hour each time. 5 days is a course of treatment.

[0065] Measurement results: Before complete recovery, the average circumference of the patient's lower leg edema can be reduced by 0.8 cm per day (before medication, Figure 4 As shown; after taking the medicine Figure 5 As shown), the thigh circumference in water can be reduced by 1.3cm.

[0066] According to the above measurement standards, the efficacy of medication was recorded in 30 patients (18 males and 12 females) with clinically significant edema after knee arthroscopy.

[0067] Method of use: According to the above method of use, apply comparative example 1 and comparative example 2 to the patient to prepare the detumescence powder.

[0068] Measurement results: A total of 10 patients (12 males and 8 females) used the Xiaozhong powder of comparative example 1. Before complete cure, the average circumference of calf edema of the patients could be reduced by 0.4 cm and the circumference of thigh edema could be reduced by 0.9 cm per day.

[0069] A total of 10 patients (6 males and 4 females) used the Xiaozhong powder of Comparative Example 2. Before complete cure, the average circumference of calf edema in patients could be reduced by 0.7 cm per day, and the circumference of thigh edema could be reduced by 1.2 cm per day. However, two cases of sensitization occurred in the 10 patients (2 female patients), and red rashes appeared. In addition, the adhesion was insufficient during use, and the drug fell off.

[0070] The above embodiments are preferred implementation modes of the present invention, but the implementation modes of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principles of the present invention should be equivalent replacement methods and are included in the protection scope of the present invention.

Claims

1. A five-flavor diuretic and swelling-removing powder, characterized in that: The invention comprises, by weight, 100-130 parts of adzuki beans, 15-26 parts of gardenias, 8-13 parts of sodium sulfate, 2-5 parts of borneol and 1-4 parts of rhubarb.

2. A five-flavor diuretic and swelling-removing powder, characterized in that: The invention is composed of 80 to 150 parts of adzuki beans, 20 parts of gardenias, 10 parts of sodium sulfate, 3 parts of borneol and 2 parts of rhubarb in parts by weight.

3. The Wuwei Lishui Xiaozhong Powder according to claim 1 or 2, characterized in that: The dosage form of the Wuwei Lishui Xiaozhong Powder is any one of powder, ointment and patch.

4. A method for preparing the Wuwei Lishui Xiaozhong Powder according to any one of claims 1 to 3, characterized in that: The following steps are involved: Grind adzuki bean, gardenia, sodium sulfate, borneol and rhubarb according to weight proportions, and mix the mixture to prepare medicinal powder.

5. The method for preparing Wuwei Lishui Xiaozhong Powder according to claim 4, characterized in that: The preparation method of the Wuwei Lishui Xiaozhong Powder also includes mixing and stirring the medicine powder with water.

6. The method for preparing Wuwei Lishui Xiaozhong Powder according to claim 5, characterized in that: The mass volume ratio of the medicinal powder to the water is 100:(10-40) g / mL.

7. Use of the Wuwei Lishui Xiaozhong Powder as claimed in any one of claims 1 to 3 in the preparation of a medicine for treating sprains, fracture swelling and / or swelling after orthopedic surgery.

8. The use according to claim 7, characterized in that: The orthopedic post-operative swelling includes knee post-operative swelling.

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