Composition with scalp dandruff removal effect, preparation method and application thereof

Abstract

The present invention provides an anti-dandruff composition and a preparation method and application thereof. The anti-dandruff composition comprises a common extract of coptis root, phellodendron, scutellaria, radix rehmanniae, radix rehmanniae prepared and a common extract of angelica and astragalus; the preparation method comprises obtaining Chinese medicinal material extracts by alcohol extraction and water extraction respectively, and then configuring the Chinese medicinal material extracts and adjusting the pH value. The present invention also provides the application of the anti-dandruff composition in hair care products. The anti-dandruff composition of the present invention can effectively inhibit the growth of Malassezia by combining a variety of Chinese herbal medicine extracts; the hair care product containing the anti-dandruff composition has good anti-inflammatory and anti-dandruff and antipruritic effects, and also has a good user experience, is non-irritating and non-allergic. The preparation method provided by the present invention has a simple process, mild conditions, short time, and is conducive to industrial production.

Description

Technical Field

[0001] The invention relates to the field of daily chemicals, and in particular to an anti-dandruff composition, a preparation method and application thereof, and a hair care product comprising the same. Background Art

[0002] Hair is a natural high-molecular keratin fiber that covers the scalp. It has the functions of preventing the scalp from dissipating heat, protecting the scalp from damage and making it beautiful. However, many people have dandruff problems to varying degrees. Dandruff is medically known as pityriasis capitis, a skin disease caused by Malassezia. The massive reproduction of Malassezia on the scalp causes excessive proliferation of the stratum corneum of the scalp, which causes the stratum corneum cells to fall off abnormally in the form of white or gray scales. This shed scale is dandruff. Dandruff is attached to the surface of the scalp and hair and falls off in large quantities. This seemingly small problem often troubles people in all aspects of work, life and social life. When dandruff occurs, it is often accompanied by symptoms such as scalp inflammation and scalp itching; if appropriate methods are not used for targeted treatment, the disease may occur periodically, recurrently or continuously, and in severe cases, it may cause damage to the scalp hair follicles and form permanent hair loss. Therefore, consumers have a continuous demand for hair care products that can effectively remove dandruff and do not recur.

[0003] Commercially available anti-dandruff shampoo and hair care products mainly reduce the growth of scalp microorganisms, inhibit the division of scalp keratinocytes, and prevent the cells that are about to fall off from accumulating into blocky scales visible to the naked eye by adding various antifungal drugs such as ketoconazole, climbazole, zinc pyrithione (ZPT), etc., so as to achieve the purpose of dandruff removal. For example, Chinese patent CN110960434B provides a scalp care shampoo composition, including: sorbitol, dipotassium glycyrrhizinate, zinc pyrrolidone carboxylate, piroctone olamine salt and climbazole. However, long-term use of such drugs is prone to drug resistance and has a greater irritation to the scalp. Therefore, the market is in urgent need of developing an anti-dandruff hair care product that does not contain antifungal drugs and has low irritation. Summary of the invention

[0004] In view of this, the present invention provides an anti-dandruff composition.

[0005] The technical solution of the present invention is as follows:

[0006] An anti-dandruff composition comprising a common extract of coptis root, phellodendron, scutellaria, raw rehmannia root, cooked rehmannia root and a common extract of angelica and astragalus;

[0007] The weight ratio of the above components is: the common extract of coptis root, phellodendron, scutellaria, raw rehmannia root and cooked rehmannia root: the common extract of angelica and astragalus = 5:2.

[0008] Coptis chinensis is the dried rhizome of Coptis chinensis Franch., Coptisdeltoidea CYCheng et Hsiao or Coptis teeta Wall., all of which are called "Wei Lian", "Ya Lian" and "Yun Lian" respectively. Coptis chinensis has many synonyms, such as Wang Lian, Zhi Lian, Ku Lian, Tuchuan Lian, Ya Lian, etc. The bitterness of Coptis chinensis is well known, but its medicinal value is also unquestionable. Modern studies have shown that Coptis chinensis has pharmacological effects such as antiviral, hypoglycemic, anti-tumor, cardiovascular system, anti-platelet aggregation and thrombolysis, and is widely used in the pharmaceutical industry.

[0009] Phellodendron chinense Schneid. or Phellodendron amurense Rupr. of the Rutaceae family is a dried bark. The former is commonly known as "Chuan Huangbai" and the latter is commonly known as "Guan Huangbai". Phellodendron can clear away heat and dampness, purge fire and eliminate steaming, detoxify and treat sores. It is used for damp-heat diarrhea, jaundice, leucorrhea, hot stranguria, beriberi, impotence, bone steaming and fatigue fever, night sweats, spermatorrhea, sores, swelling and poison, and eczema and itching. Salted Phellodendron nourishes yin and reduces fire. It is used for yin deficiency and fire, night sweats and bone steaming. Its pharmacological activity is similar to that of Coptis chinensis, both of which use berberine as the main active ingredient, and have different degrees of antibacterial effects on a variety of common pathogenic fungi.

[0010] Scutellaria baicalensis Georgi, also known as Camellia root and Tujin tea root, is a perennial herbaceous plant of the genus Scutellaria in the family Lamiaceae. In traditional Chinese medicine, the root is used as medicine. It tastes bitter and is cold in nature. It has the effects of clearing away heat and dampness, purging fire and detoxifying, stopping bleeding, and calming the fetus. It is mainly used to treat febrile diseases, upper respiratory tract infections, lung heat cough, damp-heat jaundice, pneumonia, dysentery, hemoptysis, red eyes, restless fetuses, hypertension, carbuncles, boils, etc. In addition, it also has a good effect on the treatment of skin diseases.

[0011] Rehmannia glutinosa (Gaetn.) Libosch. ex Fisch. et Mey.) is a tuberous root of the Rehmannia glutinosa family. Raw Rehmannia is made by excavating fresh Rehmannia and then drying it on a kang several times with a smokeless fire, while cooked Rehmannia is made by processing fresh Rehmannia with rice wine, Amomum villosum, and dried orange peel as auxiliary materials. Raw Rehmannia is very cold in nature and bitter in taste. It is suitable for patients with blood heat to cool blood and stop bleeding, clear heat and nourish yin; while cooked Rehmannia is slightly warm and slightly bitter. It is mainly used for patients with yin deficiency to nourish blood, nourish yin and tonify the kidney. Rehmannia contains a variety of pharmacologically active substances, including iridoid glycosides, sugars, and amino acids. It has a wide range of pharmacological activities, including regulating blood pressure and blood sugar, sedation, anti-inflammatory and anti-allergic, and anti-fungal.

[0012] Angelica sinensis is the dried root of Angelica sinensis (Oliv.) Diels, a plant of the Umbelliferae family. The whole root of Angelica sinensis is slightly cylindrical, with the upper end of the root called "head" and the main root called "body" or "cun body". The branch root is called "tail" or "thigh", and the whole is called "whole root". The whole Angelica sinensis can both replenish blood and activate blood circulation, which is collectively called "blood harmonization"; the body of Angelica sinensis replenishes blood, and the tail of Angelica sinensis breaks blood. It is mainly used for various symptoms of blood deficiency and irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain due to deficiency and cold, pain caused by blood stasis, traumatic injury, numbness and pain due to arthralgia, carbuncle, ulcer, blood deficiency and constipation. Angelica sinensis contains a variety of pharmacologically active substances such as ligustilide, ferulic acid, angelica lactone, and Angelica sinensis polysaccharide, which can resist damage to the body caused by oxygen free radicals, relieve pain, resist convulsions, and activate the immune system.

[0013] Astragalus is the dried root of Astragalusmembranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Astragalusmembranaceus (Fisch.) Bge. of the Leguminosae family. It can invigorate qi and strengthen the exterior, promote diuresis and expel toxins, discharge pus, and heal sores and promote tissue regeneration. It is used for qi deficiency and fatigue, poor appetite and loose stools, sinking of qi in the middle, chronic diarrhea and prolapse of the anus, bloody stool and metrorrhagia, spontaneous sweating due to superficial deficiency, edema due to qi deficiency, carbuncle is difficult to ulcerate, long-term ulceration does not heal, blood deficiency and jaundice, internal heat and thirst. In vitro application of Astragalus powder can inhibit a variety of pathogenic bacteria such as Shigella dysentery bacillus, anthrax bacillus, alpha-hemolytic streptococcus, beta-hemolytic streptococcus, diphtheria bacillus, pseudodiphtheria bacillus, pneumonia diplococcus, Staphylococcus aureus, lemon-colored Staphylococcus, Bacillus subtilis, etc.

[0014] Furthermore, in the above anti-dandruff composition, the extracts of Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Radix Rehmanniae, and Radix Rehmanniae Preparata are prepared by the following method:

[0015] A1. Coptidis rhizome, Phellodendron chinense, Scutellaria baicalensis, Radix Rehmanniae glutinosae, Radix Rehmanniae glutinosae were crushed into powder, sieved, and added to the reaction kettle. The weight ratio was 1:1:1:1:1:1.

[0016] A2. Soak the mixed powder of coptis root, phellodendron, scutellaria, raw rehmannia root and cooked rehmannia root in 70% ethanol solution for 2 to 4 hours, with a solid-liquid ratio of 1:10 to 12;

[0017] A3. Start stirring and extract under reflux in a water bath at 80°C for 2 to 4 times, each time for 1 to 2 hours;

[0018] A4. The reflux liquids were combined, evaporated and concentrated to obtain a 1 g / L brown liquid to obtain the extract.

[0019] Furthermore, in the above anti-dandruff composition, the Angelica and Astragalus co-extract is prepared by the following method:

[0020] B1. The angelica and astragalus were crushed into powder, sieved, and added to the reactor. The weight ratio of angelica and astragalus was 1:2;

[0021] B2. Add 5 times the total mass of angelica and astragalus to the reactor, stir, and boil 2 to 4 times, each time for 1 to 2 hours;

[0022] B3. The drug solution is filtered and concentrated by evaporation after combination to obtain a 1 g / L brown liquid, thereby obtaining the Angelica and Astragalus common extract.

[0023] The present invention also provides a method for preparing the anti-dandruff composition, comprising the following steps:

[0024] S1. Weigh the extracts of Coptis chinensis, Phellodendron chinense, Scutellaria baicalensis, Radix Rehmanniae glutinosae ... and Radix Angelicae Sinensis and Radix Astragali, place them in a container, stir them evenly, and measure the pH of the mixture;

[0025] S2. Using glacial acetic acid, the pH of the mixture is adjusted to 4.5-6.5 to obtain the anti-dandruff composition.

[0026] The present invention also provides an application of the anti-dandruff composition in preparing hair care products.

[0027] The present invention also provides a hair care product containing the anti-dandruff composition.

[0028] Further, the weight percentage of the anti-dandruff composition in the hair care product is 6 to 10%;

[0029] The hair care product also includes the following components in weight percentage: 10-20% sulfate surfactant, 8-10% detergent, 1-2% softener, 1-2% thickener, 1-1.5% hair conditioner, 0.5-1% preservative, and the balance is purified water.

[0030] Furthermore, the above-mentioned hair care product includes the following components in weight percentage: 8% anti-dandruff composition, 15% sulfate surfactant, 9% detergent, 1.5% softener, 1.5% thickener, 1.2% hair conditioner, 0.7% preservative, and the balance is purified water.

[0031] Further, in the above-mentioned hair care product, the sulfate surfactant is selected from one or more of sodium laureth sulfate, ammonium laureth sulfate, sodium lauryl sulfate, and ammonium lauryl sulfate;

[0032] The cleaning agent is selected from one or more of coco betaine, cocamidopropyl betaine, and decyl glucoside;

[0033] The softener is sodium isostearyl lactylate;

[0034] The thickener is selected from cocamide DEA and / or cocamide methyl MEA;

[0035] The hair conditioning agent is selected from one or more of hydrolyzed keratin, hydrolyzed silk protein, hydrolyzed oat protein, guar hydroxypropyltrimonium chloride, polyquaternium-10, polyquaternium-47, and PPG-3 octyl ether;

[0036] The preservative is methylparaben and / or propylparaben.

[0037] The present invention also provides another hair care product, which, in addition to the above-mentioned hair anti-dandruff composition, also comprises the following components: 20% ethanol, 3% propylene glycol, 0.5% 1,2-hexanediol, 0.5% p-hydroxyacetophenone, 0.5% PEG-40 hydrogenated castor oil, 0.1% essence, and the balance is purified water.

[0038] The beneficial effects of the present invention are as follows: the anti-dandruff composition of the present invention can effectively inhibit the growth of Malassezia by combining a variety of Chinese herbal extracts; the hair care product containing the anti-dandruff composition has good anti-inflammatory and anti-dandruff and antipruritic effects, and also has a good user experience, is non-irritating and non-allergic. The preparation method provided by the present invention has a simple process, mild conditions, a short time, and is conducive to industrial production. DETAILED DESCRIPTION

[0039] The experimental methods used in the following examples are conventional methods unless otherwise specified; the reagents, materials, etc. used in the following examples are commercially available products, or can be prepared by known methods unless otherwise specified. The experimental methods in the following examples without specifying specific conditions are usually carried out according to conventional conditions such as those described in Sambrook et al., Molecular Cloning: A Laboratory Manual (New York: Cold Spring Harbor Laboratory Press, 1989), or according to the conditions recommended by the manufacturer.

[0040] Example 1 Preparation of extracts of coptis root, phellodendron chinense, scutellaria baicalensis, raw rehmannia root and cooked rehmannia root

[0041] A1. Weigh 100g each of Coptis chinensis, Phellodendron chinense, Scutellaria baicalensis, Radix Rehmanniae glutinosae, and Rehmanniae glutinosae, crush them into powder, sieve them, and add them to the reactor;

[0042] A2. Soak the API powder in 70% ethanol solution for 3 hours;

[0043] A3. Start stirring and extract under reflux in a water bath at 80°C for 1.5 hours each time;

[0044] A4. The reflux liquids were combined, evaporated and concentrated to obtain a 1 g / L brown liquid to obtain the extract.

[0045] Other parameters are shown in Table 1.

[0046] Table 1 Preparation parameters of the common extracts of Coptis chinensis, Phellodendron amurense, Scutellaria baicalensis, Radix Rehmanniae glutinosae and Radix Rehmanniae glutinosae

[0047]

[0048] The HPLC method was used to determine the content of active ingredients in the extract and the yield of the extract. Active ingredient content = active ingredient mass in the product / product mass × 100%, extract yield = extract mass / raw material mass × 100%, active ingredient yield = active ingredient mass in the product / raw material mass × 100%. The active ingredients of Coptis chinensis and Phellodendron chinense are calculated as berberine, the active ingredients of Scutellaria baicalensis are calculated as baicalin, and the active ingredients of Rehmannia glutinosa and Rehmannia glutinosa are calculated as polysaccharides.

[0049] The test results are shown in Table 2 below.

[0050] Table 2 Test results

[0051] Serial number Active ingredient content (%) Output rate (%) Example 1-1 15.69 57.64 Example 1-2 15.24 58.55 Examples 1-3 14.79 57.41 Comparative Example 1-1 8.85 48.42 Comparative Example 1-2 13.77 52.61 Comparative Examples 1-3 12.29 44.84

[0052] As shown in Table 2 above, the effective component content of the extracts of Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Radix Rehmanniae, Radix Rehmanniae prepared from Examples 1-1 to 1-3 is about 15%, and the yield is about 57%. The effective component content and yield of the extracts of Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Radix Rehmanniae prepared from Comparative Examples 1-1 and 1-2 are lower than those from Examples 1-1 to 1-3, which shows that too few reflux times and low material-liquid ratio will affect the quality of the extracts. When the material-liquid ratio is high (Comparative Example 1-3), the effective components in the raw materials cannot be completely extracted.

[0053] Example 2 Preparation of Angelica and Astragalus Common Extract

[0054] B1. Weigh 100g of Angelica sinensis and 200g of Astragalus membranaceus, crush them into powder, sieve them, and add them to the reactor;

[0055] B2. Add angelica and astragalus to the reactor in a volume of 5 times the total mass of pure water, stir and boil for 1.5 hours each time;

[0056] B3. The drug solution is filtered and concentrated by evaporation after combination to obtain a 1 g / L brown liquid, thereby obtaining the Angelica and Astragalus common extract.

[0057] The remaining parameters are shown in Table 3.

[0058] Table 3 Preparation parameters of Angelica and Astragalus common extract

[0059] Serial number Decoction times Example 2-1 3 Example 2-2 4 Example 2-3 2 Comparative Example 2-1 1 Comparative Example 2-2 5

[0060] The content of the active ingredient in the extract and the extraction rate of the extract were detected in the same manner as in Example 1. The active ingredient of Angelica sinensis was calculated as ferulic acid, and the active ingredient of Astragalus membranaceus was calculated as astragalus polysaccharide.

[0061] The test results are shown in Table 4 below.

[0062] Table 4 Test results

[0063] Serial number Active ingredient content (%) Output rate (%) Example 2-1 11.19 44.59 Example 2-2 10.53 43.71 Example 2-3 10.88 44.10 Comparative Example 2-1 3.49 28.26 Comparative Example 2-2 10.77 43.42

[0064] As shown in Table 2 above, the effective component content of the common extracts of Angelica and Astragalus obtained in Examples 2-1 to 2-3 is about 10%, and the extraction rate is about 43%. The effective component content and extraction rate of the common extracts of Angelica and Astragalus obtained in Comparative Example 2-1 are lower than those in Examples 2-1 to 2-3, which shows that too few decoction times will affect the quality of the extracts. When the number of constructions exceeds 4 times (Comparative Example 1-2), there is no obvious improvement in the extraction of the effective components of Angelica and Astragalus.

[0065] Example 3 Preparation of anti-dandruff composition

[0066] S1. Weigh 50 g of the extract of Coptis chinensis, Phellodendron chinense, Scutellaria baicalensis, Rehmannia glutinosa, and Rehmannia glutinosa obtained in Example 1-1, and 20 g of the extract of Angelica sinensis and Astragalus membranaceus obtained in Example 2-1, place them in a container, stir them evenly, and measure the pH of the mixture;

[0067] S2. Use glacial acetic acid to adjust the pH of the mixture to obtain an anti-dandruff composition.

[0068] The remaining parameters are shown in Table 5.

[0069] Table 5 Preparation parameters of anti-dandruff composition

[0070] Serial number pH Example 3-1 5.5 Comparative Example 3-1 3.5 Comparative Example 3-2 7.5

[0071] The anti-dandruff composition prepared in Example 3-1 and Comparative Example 3-2 is a dark brown thick liquid with a medicinal aroma, which is soft and not pungent. The anti-dandruff composition prepared in Comparative Example 3-1 has a distinct acetic acid smell, and its acidity is too high, which easily irritates the scalp and aggravates dandruff. Although the anti-dandruff composition prepared in Comparative Example 3-2 has no difference in appearance, its pH is alkaline relative to the normal pH range of the human scalp, and long-term use is likely to damage the scalp microecological environment, causing skin problems such as dryness and itching.

[0072] Example 4 Preparation of a hair care product containing an anti-dandruff composition

[0073] (1) Preparation of hair care products containing sulfate surfactants

[0074] C1. Weigh sulfate surfactant, detergent, sodium isostearyl lactylate, thickener, and purified water, put into a reactor, heat to 80°C, and stir evenly;

[0075] C2. Continue stirring, when the reactor temperature drops to 60 ° C, weigh the anti-dandruff composition prepared in Example 3-1, the hair conditioner, and the preservative, put into the reactor, and stir evenly;

[0076] C3. When the temperature in the reaction vessel drops to 30°C, a hair care product containing an anti-dandruff composition is obtained. (2) Preparation of a hair care product containing multiple alcohols

[0077] D1. Mix propylene glycol, 1,2-hexanediol and p-hydroxyacetophenone, heat to 50°C and stir until all dissolved;

[0078] D2. Cool the above mixture to room temperature;

[0079] D3. Add flavor and PEG-40 hydrogenated castor oil to the mixture and stir evenly;

[0080] D4. Add ethanol to the mixture obtained in D4 and stir evenly;

[0081] D5. Add purified water and the anti-dandruff composition and stir evenly to obtain.

[0082] The remaining parameters are shown in Tables 6 and 7.

[0083] Table 6 Preparation parameters of hair care products containing sulfate surfactants

[0084]

[0085] Table 7 Preparation parameters of hair care products containing various alcohols

[0086]

[0087] The hair care products prepared in each of the examples and comparative examples of this group are all 100 g, and the balance is made up by purified water.

[0088] The hair care products prepared in the examples and comparative examples of this group were used to clean wigs coated with an appropriate amount of hair care essential oil. The hair care products prepared in Examples 4-1 to 4-3 and Comparative Example 4-1 were able to clean the wigs and keep them smooth, not dry or frizzy. The hair care products prepared in Comparative Examples 4-2 and 4-3 were unable to clean the wigs and felt greasy or sticky when touched. It can be seen that only a rationally proportioned surfactant system (Examples 4-1 to 4-3) can effectively clean the hair.

[0089] Test Example 1 Antidandruff Performance Test of Antidandruff Composition

[0090] The anti-dandruff efficacy of the anti-dandruff composition prepared in Example 3-1 was tested according to QTC-C-LAB-TOP-057 "In vitro test method for anti-dandruff efficacy of cosmetics (inhibitory ring method)".

[0091] The sample containing the antibacterial agent is placed on a plate stained with Malassezia furfur. The sample is continuously dissolved and diffused through the agar to form different concentration gradients to show its antibacterial effect. The size of the antibacterial ring is measured to determine whether it has antibacterial ability.

[0092] The negative control sample should not produce an antibacterial ring. If the diameter of the antibacterial ring of the test sample is greater than 7mm, it is judged to have an antibacterial effect; if the diameter of the antibacterial ring is ≤7mm, it is judged to have no antibacterial effect. If the three repeated tests (a total of 12 samples) have an antibacterial effect, it is judged to be qualified.

[0093] The anti-dandruff composition prepared in Example 3-1 was mixed with water at a mass ratio of 1:1, and 20uL was taken and dripped onto a filter paper to prepare a test sample, which was dried for later use. 5 CFU / mL~5.0×10 6 CFU / mL Malassezia furfur suspension is evenly applied on the surface of a suitable culture medium plate for 3 times. Place 1 infected plate for each test, 4 test samples and 1 negative control sample on each plate, for a total of 5 samples. Cover the plate, incubate at (36±1)℃ for 72h, observe the results, measure the diameter of the inhibition ring (including the patch) with a vernier caliper and record it. Add 20uL of purified water to the negative control sample.

[0094] The test results are shown in Table 7 below.

[0095] Table 7 Anti-dandruff performance test results

[0096]

[0097] Malassezia is one of the important factors in the formation of dandruff. The growth and decline of Malassezia is directly correlated with the amount of dandruff. Malassezia furfur is a relatively in-depth study of the bacteria in the genus Malassezia. It was isolated from human dandruff (pityriasis capitis) and is representative of indicator bacteria.

[0098] As shown in Table 7 above, in the three repeated tests of the tested samples, no antibacterial rings were produced in the negative control samples, while the diameters of the antibacterial rings produced by the test samples were all greater than 7 mm, which indicates that the anti-dandruff composition prepared in Example 3-1 has the ability to inhibit Malassezia furfur and can effectively reduce the occurrence of dandruff.

[0099] Test Example 2 Efficacy test of hair care products containing anti-dandruff composition

[0100] The hair care products prepared in Example 4-1 (experimental group 1), Example 4-4 (experimental group 2), Comparative Example 4-1 (blank group 1), and the commercially available anti-dandruff care essence in Comparative Example 4-4 (blank group 2) were used for product efficacy testing.

[0101] Subject screening:

[0102] (1) A total of 70 subjects aged 25 to 60 years were randomly divided into two groups according to age, with 35 subjects in each group;

[0103] (2) self-assessment of dandruff and scalp itching with a score of 4 or above on a 7-point scale;

[0104] (3) Be able to understand the testing process, voluntarily participate in the test, and comply with the test requirements.

[0105] One week before the test, the subjects stopped using the hair care products with the same efficacy. The subjects used the hair care products of the corresponding group for 28 consecutive days. On the 14th and 28th days, the testers scored the questionnaire test items based on their experience. The scoring standard adopts a 7-point system, with 1 point being the worst and 7 points being the best. The higher the score, the better. The final score is displayed as the average score after statistics.

[0106] The test results are shown in Tables 8-1 to 8-2 below.

[0107] Table 8-1 Anti-dandruff efficacy test results of hair care products containing anti-dandruff compositions

[0108] Group D0 D14 D28 Experimental Group 1 4.98 4.04 3.27 Experimental Group 2 4.99 4.13 3.32 Control group 1 5.05 4.85 4.91 Control group 2 5.02 4.16 3.44

[0109] Table 8-2 Overall use experience rating of hair care products containing anti-dandruff compositions

[0110] Group D14 D28 Experimental Group 1 5.84 5.67 Experimental Group 2 5.58 5.74 Control group 1 3.53 2.49 Control group 2 5.26 5.10

[0111] As shown in Tables 8-1 to 8-2 above, compared with hair care products not containing the anti-dandruff composition of the present invention, hair care products containing the composition can effectively reduce the occurrence of dandruff in users, and this effect is similar to that of commercially available hair care products; and the feeling of use is good, and no adverse reactions such as irritation and allergies occur.

[0112] Although the embodiments of the present application have been shown and described above, it is understood that the above embodiments are exemplary and cannot be construed as limitations on the present application. A person skilled in the art may change, modify, replace and modify the above embodiments within the scope of the present application.

Claims

1. An anti-dandruff composition comprising a common extract of coptis root, phellodendron, scutellaria, raw rehmannia root, cooked rehmannia root and a common extract of angelica and astragalus; The weight ratio of the above components is: the common extract of coptis root, phellodendron, scutellaria, raw rehmannia root, and cooked rehmannia root: the common extract of angelica and astragalus root = 5:2; The extract of coptis root, phellodendron chinense, scutellaria baicalensis, raw rehmannia root and cooked rehmannia root is prepared by the following method: A1) Coptidis rhizome, Phellodendron amurense, Scutellaria baicalensis, Radix Rehmanniae glutinosae, and Radix Rehmanniae glutinosae are crushed into powder, sieved, and added into a reaction kettle, with a weight ratio of Coptidis rhizome: Phellodendron amurense: Scutellaria baicalensis: Radix Rehmanniae glutinosae: Radix Rehmanniae glutinos A2) soaking a mixed powder of coptis root, phellodendron, scutellaria, raw rehmannia root and cooked rehmannia root in a 70% ethanol solution for 2 to 4 hours, with a solid-liquid ratio of 1:10 to 12; A3) Start stirring and extract under reflux in a water bath at 80°C for 2 to 4 times, each time for 1 to 2 hours; A4) combining the refluxed liquids, evaporating and concentrating to obtain a 1 g / L brown liquid, thereby obtaining the extract of coptis root, phellodendron amurense, scutellaria baicalensis, radix rehmanniae, and radix rehmanniae preparata; The Angelica and Astragalus common extract is prepared by the following method: B1) crushing angelica and astragalus into powder, sieving, and adding into a reaction kettle, wherein the weight ratio of angelica to astragalus is 1:2; B2) adding 5 times the total weight of angelica and astragalus to the reaction kettle with pure water, stirring, and boiling for 2 to 4 times, each time for 1 to 2 hours; B3) filtering to obtain the medicinal solution, combining and evaporating and concentrating to obtain a 1 g / L brown liquid, thus obtaining the Angelica and Astragalus common extract.

2. A method for preparing the anti-dandruff composition according to claim 1, comprising the following steps: S1) Weighing a common extract of coptis root, phellodendron, scutellaria, raw rehmannia root, cooked rehmannia root and a common extract of angelica and astragalus, placing them in a container, stirring them evenly, and measuring the pH of the mixture; S2) adjusting the pH of the mixture to 4.5-6.5 using glacial acetic acid to obtain the anti-dandruff composition.

3. Use of the anti-dandruff composition according to any one of claims 1 to 2 in the preparation of hair care products.

4. A hair care product comprising the anti-dandruff composition according to any one of claims 1 to 2.

5. The hair care product according to claim 4, characterized in that: The weight percentage of the anti-dandruff composition in the hair care product is 6-10%.

6. The hair care product according to claim 5, further comprising the following components in weight percentage: 10-20% sulfate surfactant, 8-10% detergent, 1-2% softener, 1-2% thickener, 1-1.5% hair conditioner, 0.5-1% preservative, and the balance being purified water.

7. The hair care product according to claim 5 or 6, characterized in that: The hair care product comprises the following components in percentage by weight: 8% of an anti-dandruff composition, 15% of a sulfate surfactant, 9% of a detergent, 1.5% of a softener, 1.5% of a thickener, 1.2% of a hair conditioner, 0.7% of a preservative, and the remainder being purified water; The sulfate surfactant is selected from one or more of sodium laureth sulfate, ammonium laureth sulfate, sodium lauryl sulfate, and ammonium lauryl sulfate; the detergent is selected from one or more of coco betaine, cocamidopropyl betaine, and decyl glucoside; The softener is sodium isostearyl lactylate; The thickener is selected from cocamide DEA and / or cocamide methyl MEA; The hair conditioning agent is selected from one or more of hydrolyzed keratin, hydrolyzed silk protein, hydrolyzed oat protein, guar hydroxypropyltrimonium chloride, polyquaternium-10, polyquaternium-47, and PPG-3 octyl ether; The preservative is methylparaben and / or propylparaben.

8. The hair care product according to claim 5, further comprising the following components in weight percentage: 20% ethanol, 3% propylene glycol, 0.5% 1,2-hexanediol, 0.5% p-hydroxyacetophenone, 0.5% PEG-40 hydrogenated castor oil, 0.1% essence, and the balance being purified water.

Images