FLASH treatment system, beam safety locking method and related equipment

Abstract

The present application provides a FLASH treatment system, a beam safety locking method and related equipment, and relates to the field of particle radiotherapy technology. The method includes: obtaining the proton charge amount of a single beam output as a first charge amount; judging whether the first charge amount exceeds a first threshold value; and performing beam control according to the judgment result: if the first charge amount exceeds the first threshold value; performing a first safety lock and prohibiting beam output; if not, allowing one beam output, and determining the beam output locking duration, and performing a second safety lock within the beam output locking duration; wherein, during the second safety lock period, loading of the beam output is not allowed. The present application is used to perform beam output control according to user needs, and to design a safety interlock so that the accelerator can no longer draw out a proton beam within a period of time after the beam output FLASH, so as to reduce the average dose rate on a time scale of hours. Ordinary proton accelerator rooms can also implement proton FLASH therapy, which is conducive to the promotion of proton FLASH therapy.

Description

Technical Field

[0001] The present application relates to the field of particle radiotherapy technology, and in particular to a FLASH treatment system, a beam safety locking method, and related equipment. Background Art

[0002] In the field of particle radiotherapy, the accuracy of dose calculation is one of the decisive factors for achieving high-quality treatment results. For proton radiotherapy, proton dose calculation methods involve two main approaches: analytical method and Monte Carlo simulation. The analytical method often converts the Hounsfield Units (HU) values ​​obtained from CT scans into stopping power ratios for dose calculation. Although this does not involve the specific tissue composition of the voxel, this analytical algorithm is difficult to provide accurate dose calculations when dealing with heterogeneous media (such as the lungs). This is because these algorithms can only perform approximate calculations in terms of multi-elastic Coulomb scattering, elastic and inelastic nuclear reactions, and cannot achieve accurate modeling.

[0003] Flash therapy is a new type of non-invasive external beam radiotherapy technology. It is a non-invasive way to give a single dose of radiation in a very short time, so as to obtain an extremely high radiation dose rate (usually an average dose rate of more than 100Gy / s is given within 50ms). This method of applying an extremely high radiation dose rate to biological cells or tissues is called Flash therapy (flash radiotherapy). Compared with conventional dose rate (1-7cGy / s) radiotherapy, Flash therapy delivers a high radiation dose in a very short time (<0.1s). High dose rate irradiation causes oxygen depletion in tissues, making healthy tissues resistant to radiation, so that dose escalation therapy that destroys tumor tissues can be implemented under conditions of high hypoxia. Experimental results show that Flash therapy greatly reduces damage to normal tissues while maintaining the same or even better tumor control rate. Compared with conventional radiotherapy, the incidence of radiation dermatitis in proton Flash therapy is reduced by an average of 35%. In accordance with the requirements for radiation safety and protection, in ordinary proton accelerator rooms, that is, rooms designed and planned with non-FLASH beam current intensity as the radiation source item, FLASH beams are not allowed to be drawn out, or very thick shielding walls must be designed to ensure that when the accelerator draws out the proton beam, the dose rate outside the room is less than 2.5 μSv / h. Because the required walls are particularly thick, there are no FLASH proton rooms located in hospitals in China. From the perspective of thickening the walls, the dose rate outside the room is reduced. How to implement FLASH operation in an ordinary proton accelerator room to avoid special thickening of the proton accelerator room walls is a technical problem to be solved by this application. Summary of the invention

[0004] The purpose of the present application is to provide a FLASH beam safety locking method and related equipment, which are used to control the beam output according to user needs and design a safety interlock so that the accelerator cannot emit a proton beam for a period of time after the FLASH beam is emitted, so as to reduce the average dose rate on a time scale of hours.

[0005] The purpose of this application is achieved by the following technical solutions:

[0006] In a first aspect, the present application provides a FLASH beam safety locking method, the method comprising:

[0007] Acquiring a proton charge amount of a single beam output as a first charge amount;

[0008] determining whether the first charge amount exceeds a first threshold;

[0009] The beam emission is controlled according to the determination result: if the first charge amount exceeds the first threshold value, a first safety lock is performed to prohibit the beam emission; if not, the beam emission is allowed and the beam emission lock duration is calculated.

[0010] Further, the FLASH beam current safety locking method, the if not, then allow beam emission, and calculate the beam emission locking time length includes, if the first charge amount is less than or equal to the first threshold, then allow beam emission once, and determine the beam emission locking time length, and perform a second safety locking within the beam emission locking time length; wherein, during the second safety locking period, loading of the beam current is not allowed.

[0011] Optionally, in the FLASH beam safety locking method, the beam lock duration is:

[0012] T=N / 3600-t

[0013] Wherein, T is the beam lock time; t is the irradiation time, 3600 units are seconds, and N is the first charge amount; Optionally, in the FLASH beam current safety locking method, the beam lock duration is:

[0014] When the first charge amount is less than the second threshold, T=T1;

[0015] When the first charge amount is greater than or equal to the second threshold and less than the third threshold, T=T2;

[0016] When the first charge amount is greater than or equal to the third threshold, T=T3;

[0017] Wherein, T is the beam lock duration, and T1, T2, and T3 are preset durations respectively.

[0018] Optionally, in a method for safely locking a FLASH beam, the beam lock duration is:

[0019] T=N / 3600

[0020] Wherein, T is the beam lock time; 3600 is in seconds, and N is the first charge; is the first threshold.

[0021] Preferably, in the FLASH beam safety locking method, the first threshold value comprises:

[0022]

[0023] in is the first threshold, is the preset proton flux intensity at the beam outlet, in nA. K Coefficient, K>0.

[0024] On the other hand, the present application provides a FLASH beam safety locking device, the device comprising:

[0025] Output charge quantity acquisition module: used for acquiring the proton charge quantity of a single beam output as the first charge quantity;

[0026] A determination module, configured to determine whether the first charge amount exceeds a first threshold;

[0027] The execution module is used to perform beam emission control according to the determination result: if the first charge amount exceeds the first threshold value, a first safety lock is performed to prohibit beam emission; if not, beam emission is allowed and the beam emission lock duration is calculated. In a third aspect, the present application provides an electronic device, the electronic device comprising a memory and at least one processor, the memory storing a computer program, and the at least one processor being configured to implement the following steps when executing the computer program:

[0028] Acquiring a proton charge amount of a single beam output as a first charge amount;

[0029] determining whether the first charge amount exceeds a first threshold;

[0030] The beam emission is controlled according to the determination result: if the first charge amount exceeds the first threshold value, a first safety lock is performed to prohibit the beam emission; if not, the beam emission is allowed and the beam emission lock duration is calculated.

[0031] Optionally, in the electronic device described in the present application, the at least one processor is configured to acquire the beam lock duration in the following manner when executing the computer program:

[0032] T=N / 3600-t

[0033] Wherein, T is the beam lock time; t is the irradiation time, 3600 units are seconds, and N is the first charge amount; is the first threshold.

[0034] Optionally, in the electronic device described in the present application, the at least one processor is configured to acquire the beam lock duration in the following manner when executing the computer program:

[0035] When the first charge amount is less than the second threshold, T=T1;

[0036] When the first charge amount is greater than or equal to the second threshold and less than the third threshold, T=T2;

[0037] When the first charge amount is greater than or equal to the third threshold and less than the fourth threshold, T=T3;

[0038] Wherein, T is the beam lock duration, and T1, T2, and T3 are preset durations respectively.

[0039] Optionally, in the electronic device described in the present application, the at least one processor is configured to acquire the beam lock duration in the following manner when executing the computer program:

[0040] T=N / 3600

[0041] Wherein, T is the beam lock time; 3600 is in seconds, and N is the first charge; is the first threshold.

[0042] In a fourth aspect, the present application provides a FLASH treatment system, the treatment system comprising:

[0043] Radiotherapy equipment and any FLASH beam safety locking device described in this application;

[0044] The radiotherapy device is used to perform radiotherapy on a patient.

[0045] In a fifth aspect, the present application provides a computer-readable storage medium, wherein the storage medium stores computer instructions. When a computer reads the computer instructions, the computer executes any one of the FLASH beam safety locking methods described in the present application.

[0046] The effects of the present application include at least: by judging whether the first charge exceeds the first threshold, the safe control of the proton beam output is achieved. If the first charge exceeds the threshold, the system will perform a first safety lock and prohibit beam output to avoid possible safety risks. This can improve the safety of proton therapy equipment and protect the safety of patients and operators. When the first charge is less than or equal to the first threshold, a beam is allowed to be output once, and a second safety lock is performed according to the set beam output lock duration. This flexible beam output control method can be adjusted according to specific needs to ensure that the output of the proton beam is within a safe range and provide effective treatment for patients. The second safety lock is performed within the beam output lock duration, and the beam output is not allowed to be loaded, which effectively prevents unsafe radiation leakage. This can protect the surrounding environment and staff from unnecessary radiation exposure and meet the requirements of radiation safety management. Through the above method, the safety of the FLASH beam can be improved, the beam output can be flexibly controlled, and radiation leakage can be effectively prevented and controlled. This will help improve the safety performance of proton therapy equipment, ensure the safety of patients and operators, and provide reliable treatment effects for proton therapy. Ensure that the dose rate outside the proton accelerator room (including ordinary proton accelerator room) is lower than the requirements of radiation safety and protection. Ordinary proton accelerator rooms can also implement proton FLASH therapy, which is conducive to the promotion of proton FLASH therapy and provides a guarantee for more patients to have the opportunity to receive proton FLASH therapy. BRIEF DESCRIPTION OF THE DRAWINGS

[0047] The present application is further described below in conjunction with the accompanying drawings and embodiments.

[0048] Figure 1 It is a schematic diagram of a safe locking method for a FLASH beam provided in an embodiment of the present application;

[0049] Figure 2 It is a schematic diagram of the flow of a method for safely locking a FLASH beam provided in an embodiment of the present application;

[0050] Figure 3 This is a schematic diagram of the load shielding design of a common proton accelerator room;

[0051] Figure 4 It is a structural schematic diagram of an electronic device provided in an embodiment of the present application. DETAILED DESCRIPTION

[0052] Below, the present application is further described in conjunction with the accompanying drawings and specific implementation methods. It should be noted that, under the premise of no conflict, the various embodiments or technical features described below can be arbitrarily combined to form a new embodiment.

[0053] Before introducing this application, the safety control requirements for radiation and treatment liberation are first introduced:

[0054] The reference control level of the dose rate outside the wall is limited to 2.5 μSv / h. However, in the previous shielding design process, the maximum dose rate per second was calculated with a time interval of seconds and converted to hours. However, the traditional beam can emit beams continuously, allowing continuous beam emission within 1 hour (or approximately 1 hour).

[0055] The ambient dose equivalent rate at 30 cm outside the wall and entrance door of the treatment room (excluding mobile accelerator treatment room) should not be greater than the ambient dose equivalent rate reference control level determined by the following a), b) and c) ;

[0056] a) Using the weekly workload of radiotherapy, the utilization factor and residence factor of the location of the point of interest, the reference control level of the peripheral dose equivalent rate of the point of interest is obtained from the reference control level of weekly dose : See formula (1)

[0057] (1)

[0058] is the reference control level of ambient dose equivalent rate, in microsievert per hour ( Sv / h);

[0059] is the weekly dose reference control level, in microsieverts per week ( Sv / week), the value is taken as follows: Staff in the control area outside the radiotherapy room: 100 Sv / week; Personnel in non-controlled areas outside the radiotherapy room: Sv / week;

[0060] The maximum cumulative exposure hours of the equipment per week, in hours per week (h / week);

[0061] U is the utilization factor of the treatment device irradiating in the direction of the focus point;

[0062] Y is the residence factor of the person at the location of interest;

[0063] b) Determine the reference control level of the maximum ambient dose equivalent rate of the concerned point according to the different personnel residence factors of the concerned point :

[0064] 1) Places with personnel residence factor T>1 / 2: ;

[0065] 2) Places with a personnel residence factor T ≤ 1 / 2: ;

[0066] c) The reference control level sheet of the ambient dose equivalent rate derived from a) above and b) the highest ambient dose equivalent rate reference control level , select the smaller one as the reference control level of the ambient dose equivalent rate of the focus point .

[0067] Through radiation environmental assessment and shielding design, simulation calculation was performed with a proton flux intensity of 1.2 nA at the beam outlet. The reference control level of the dose rate outside the wall was within 2.5 μSv / h within one hour.

[0068] See also Figure 1 , the embodiment of the present application provides a FLASH beam safety locking method, the method comprising:

[0069] Acquiring a proton charge amount of a single beam output as a first charge amount;

[0070] determining whether the first charge amount exceeds a first threshold;

[0071] The beam emission is controlled according to the determination result: if the first charge amount exceeds the first threshold value, the first safety lock is performed to prohibit beam emission; if not, the FLASH safety lock is green, beam emission is allowed, and the beam emission lock time after beam emission is calculated.

[0072] In one embodiment of the present application, if not, beam emission is allowed and the beam emission locking time is calculated, including: if the first charge amount is less than or equal to the first threshold, beam emission is allowed once, and the beam emission locking time is determined, and a second safety lock is performed within the beam emission locking time; wherein, during the second safety lock, loading of beam current is not allowed.

[0073] During the beam lock time, the second safety lock is performed. During this period, the beam is not loaded to prevent unsafe radiation leakage. After the second safety lock is completed, the beam can be reloaded for treatment.

[0074] The working principle of the above technical solution is: The proton charge amount of a single beam output is obtained as the first charge amount. This process is obtained through a beam plan, which is formulated according to treatment requirements and equipment parameters. Specifically, the beam plan refers to a plan that determines the output intensity and distribution of the proton beam over time to achieve the treatment goal.

[0075] Determine whether the first charge exceeds a first threshold. The first threshold is a pre-set upper limit of the proton charge. If the first charge exceeds the threshold, it indicates that there may be a safety risk and a safety lock is required.

[0076] The beam emission is controlled according to the determination result. If the first charge amount exceeds the first threshold, the first safety lock is performed to prohibit the beam emission to prevent unsafe radiation leakage. If the first charge amount does not exceed the first threshold, the beam emission is allowed and the beam emission lock duration is calculated.

[0077] The output of the beam is controlled by calculating the beam lock time. When the secondary proton beam output ends, the system is locked, that is, the beam lock time. During this period of time, the proton beam is still prohibited from output until the beam lock time reaches the preset time length before it is allowed to output again. This method can achieve safety control by real-time detection of the charge of the proton beam, ensuring that the output of the proton beam is within a safe range and preventing radiation leakage from causing harm to the human body and the environment.

[0078] The effect of the above technical solution is: by judging whether the first charge exceeds the first threshold, the safe control of the proton beam output is achieved. If the first charge exceeds the threshold, the system will perform a first safety lock and prohibit beam output to avoid possible safety risks. This can improve the safety of proton therapy equipment and protect the safety of patients and operators. When the first charge is less than or equal to the first threshold, a beam is allowed to be output once, and a second safety lock is performed according to the set beam output lock duration. This flexible beam output control method can be adjusted according to specific needs to ensure that the output of the proton beam is within a safe range and provide effective treatment for patients. The second safety lock is performed within the beam output lock duration, and the beam output is not loaded, which effectively prevents unsafe radiation leakage. This can protect the surrounding environment and staff from unnecessary radiation exposure and meet the requirements of radiation safety management. Through the above method, the safety of the FLASH beam can be improved, the beam output can be flexibly controlled, and radiation leakage can be effectively prevented and controlled. This will help improve the safety performance of proton therapy equipment, ensure the safety of patients and operators, and provide reliable treatment effects for proton therapy.

[0079] In one embodiment of the present application, a FLASH beam safety locking method is used, wherein the beam locking time is:

[0080] T=N / 3600-t

[0081] Wherein, T is the beam lock time; t is the irradiation time, 3600 units are seconds, and N is the first charge amount; is the first threshold.

[0082] In another embodiment of the present application, a FLASH beam safety locking method is used, wherein the beam locking time is:

[0083] T=N / 3600

[0084] Wherein, T is the beam lock time; 3600 is in seconds, and N is the first charge; is the first threshold.

[0085] The working principle of the above technical solution is: according to the first charge amount N and the first threshold The ratio of N / Indicates the ratio between the current proton beam charge and the set first threshold. The larger the ratio, the greater the output charge of the proton beam, and the longer the lock time should be to ensure treatment safety. N / The purpose of multiplying by 3600 is to convert the result into seconds for comparison with the irradiation time t. During the beam lockout time, the second safety lockout is performed to prohibit the continued output of the proton beam to avoid radiation leakage and patient injury.

[0086] The effect of the above technical solution is: according to the beam lock time algorithm, by adjusting the first threshold The setting value of the beam lock time can be flexibly controlled. When the charge of the proton beam is small and does not exceed the first threshold, it can be quickly unlocked and treated; when the charge exceeds the threshold, the locking mechanism is automatically triggered to lock safely. This adjustability makes proton beam therapy more flexible and safe. Since the charge and irradiation time of the proton beam are obtained in real time, the appropriate beam lock time can be accurately calculated according to different treatment needs and actual conditions, thereby maximizing the treatment effect while ensuring safety. The FLASH beam safety locking method can prevent the risk of equipment failure or damage caused by excessive proton beam output. By limiting the output charge and setting the beam lock time, the service life of the equipment can be effectively extended and the maintenance and replacement costs can be reduced. In general, this method improves the safety and reliability of FLASH beam therapy by setting thresholds and dynamically adjusting the beam lock time, while ensuring the maximization of the treatment effect.

[0087] In another embodiment of the present application, a FLASH beam safety locking method is provided, wherein the beam locking time is:

[0088] When the first charge amount is less than the second threshold, T=T1;

[0089] When the first charge amount is greater than or equal to the second threshold and less than the third threshold, T=T2;

[0090] When the first charge amount is greater than or equal to the third threshold value and less than the fourth threshold value, T=T3; and so on;

[0091] Wherein, T is the beam lock duration, T1, T2, T3 are preset durations respectively; T1 is between 400 seconds and 700 seconds, preferably 600 seconds; T3>T2>T1;

[0092] The third threshold value may be twice the second threshold value, and the fourth threshold value may be three times the second threshold value, and the corresponding T2 is twice T1, and the corresponding T3 is three times T1. The second threshold value, the third threshold value, and the fourth threshold value are respectively less than or equal to the first threshold value; the second threshold value is between 600C and 800C, preferably 720C (Coulomb).

[0093] The working principle of the above technical solution is: according to the different ranges of the first charge, the system will automatically select the corresponding beam lock time to limit. When the first charge is within a specific range, the corresponding preset time is triggered to limit the output time of the proton beam and ensure the safety of the treatment. The system needs to monitor the first charge when the proton beam is output in real time so as to judge the current situation and respond in time. Through precise monitoring and data acquisition, timely control and adjustment of the proton beam output can be ensured to avoid potential safety risks caused by excessive output. By setting the multiple relationship between the second threshold, the third threshold, the fourth threshold and the preset time, the proton beam output time in different ranges can be flexibly adjusted according to actual needs. In this way, the beam flow can be graded according to the first charge, while ensuring the balance between treatment effect and safety. For different first charge situations, the system needs to have a fast response speed and be able to adjust the beam lock time within milliseconds. This ensures that when an abnormal situation occurs during the proton beam output, the system can respond quickly to ensure the safety of treatment. In summary, by dynamically adjusting the beam lock time, real-time monitoring of the first charge amount, the threshold multiple relationship and the system response speed, the technical solution of setting the beam lock time according to different situations can achieve fine control of the FLASH beam output, thereby ensuring the safety and adjustability of the treatment.

[0094] The effect of the above technical solution is: by adjusting the beam lock time based on the size of the first charge, the hierarchical control of the FLASH beam output can be achieved. In this way, different beam lock time limits can be achieved within different charge ranges according to the specific proton beam output situation, so as to better adapt to different treatment needs and ensure safe radiation; setting different preset time lengths T1, T2, T3, and combining the threshold multiple relationship, the time point of proton beam output can be effectively controlled to ensure that there will be no excessive beam effect during the treatment process, thereby improving the safety of treatment. According to specific needs, the appropriate preset time length and threshold are set, so that the system has strong adjustability. In this way, it can be flexibly adjusted according to the conditions of different patients and the needs of different treatment stages, which improves the personalization and pertinence of the treatment. By setting appropriate thresholds and preset time lengths, the impact and pressure on the system can be reduced, thereby improving the stability and reliability of the system and ensuring the normal operation of the system during long-term operation. The preferred second threshold and preset time length can optimize the performance of the system to a certain extent, so that the system can achieve better output effects under different working conditions, and improve the overall performance of the system. In summary, this FLASH beam safety locking method can achieve refined control and safety assurance of beam output, improve the adjustability and stability of the system, and provide a safer, more effective and personalized solution for medical treatment.

[0095] In an embodiment of the present application, the FLASH beam safety locking method, the first threshold comprises:

[0096]

[0097] in is the first threshold, is the preset proton flux intensity at the beam outlet, in nA. K Coefficient, K>0; Preferably it is 1.2nA.

[0098] The working principle of the above technical solution is: the first threshold value is calculated in the following way:

[0099] in, Represents the first threshold, in coulomb (C), Indicates the preset proton flux intensity at the beam outlet, in nanoamperes (nA), and K is a coefficient (K > 0). To calculate the first threshold .

[0100] K= /

[0101] in, Set the cutting time scale for the user in hours. is the actual proton flux intensity at the beam outlet, in nanoamperes (nA);

[0102] According to the simulation results, When the current is 1.2 nA, the reference control level of the dose rate outside the wall is within 2.5 μSv / h. This simulation is calculated by cutting the time by one hour.

[0103] In actual applications, the device's beam port proton flow capacity can reach 35~50 nA; at the same time, different users may have different cutting time scales, which may be one and a half hours, half an hour, 20 minutes, and so on, so a coefficient K is set. According to the user's cutting time scale and the actual proton current intensity, different thresholds can be adjusted. It is determined based on the actual system performance and treatment needs to ensure the accuracy and operability of the safety lock.

[0104] If the beam charge is less than or equal to the first threshold , the beam is emitted normally; after the beam is emitted, the system enters the locked state and sets the corresponding beam locking time T according to the preset time.

[0105] The upper threshold can be preset according to the real-time proton flux intensity and time cutting requirements to achieve safe limits on the FLASH beam output. When the proton flux intensity exceeds the preset value, the system will automatically trigger the locking mechanism to ensure that the beam output is within a safe range and lock it according to the preset duration. This can effectively protect the safety of patients and equipment and improve the controllability and accuracy of treatment.

[0106] The present application also proposes a FLASH beam safety locking device, the device comprising:

[0107] Output charge quantity acquisition module: used for acquiring the proton charge quantity of a single beam output as the first charge quantity;

[0108] A determination module, configured to determine whether the first charge amount exceeds a first threshold;

[0109] The execution module is used to control the beam emission according to the determination result: if the first charge amount exceeds the first threshold value, a first safety lock is performed to prohibit the beam emission; if not, the beam emission is allowed and the beam emission lock duration is calculated.

[0110] The execution module is specifically as follows: if the first charge amount is less than or equal to the first threshold, a beam emission is allowed; after the beam emission, a beam emission locking time is determined, and a second safety locking is performed within the beam emission locking time; during the second safety locking period, no beam current is loaded.

[0111] In some embodiments, the beam lock duration in the execution module is:

[0112] T=N / 3600-t

[0113] Wherein, T is the beam lock time; t is the irradiation time, 3600 units are seconds, and N is the first charge amount; is the first threshold.

[0114] In some other embodiments, the beam lock duration in the execution module is:

[0115] T=N / 3600

[0116] Wherein, T is the beam lock time; 3600 is in seconds, and N is the first charge; is the first threshold.

[0117] In some other embodiments, the beam lock duration in the execution module is:

[0118] When the first charge amount is less than the second threshold, T=T1;

[0119] When the first charge amount is greater than or equal to the second threshold and less than the third threshold, T=T2;

[0120] When the first charge amount is greater than or equal to the third threshold value and less than the fourth threshold value, T=T3; and so on;

[0121] Wherein, T is the beam lock duration, T1, T2, T3 are preset durations respectively; T1 is between 400 seconds and 700 seconds, preferably 600 seconds; T3>T2>T1;

[0122] The third threshold value may be twice the second threshold value, and the fourth threshold value may be three times the second threshold value, and the corresponding T2 is twice T1, and the corresponding T3 is three times T1. The second threshold value, the third threshold value, and the fourth threshold value are respectively less than or equal to the first threshold value; the second threshold value is between 600C and 800C, preferably 720C (Coulomb).

[0123] The first threshold can be set according to user needs:

[0124]

[0125] in, Represents the first threshold, in coulomb (C), Indicates the preset proton flux intensity at the beam outlet, in nanoamperes (nA), and K is a coefficient (K > 0). To calculate the first threshold .

[0126] K= /

[0127] in, Set the cutting time scale for the user in hours. is the actual proton flux intensity at the beam outlet, in nanoamperes (nA);

[0128] According to the simulation results, When the current is 1.2 nA, the reference control level of the dose rate outside the wall is within 2.5 μSv / h. This simulation is calculated by cutting the time by one hour.

[0129] In actual applications, the device's beam port proton flow capacity can reach 35~50 nA; at the same time, different users may have different cutting time scales, which may be one and a half hours, half an hour, 20 minutes, and so on, so a coefficient K is set. According to the user's cutting time scale and the actual proton current intensity, different thresholds can be adjusted. It is determined based on the actual system performance and treatment needs to ensure the accuracy and operability of the safety lock.

[0130] The working principle and effect of the above steps are the same as those of the FLASH beam safety locking method in the embodiment, and will not be described in detail here.

[0131] Some embodiments of the present application provide an electronic device, the electronic device comprising a memory and at least one processor, the memory storing a computer program, and the at least one processor being configured to implement the following steps when executing the computer program:

[0132] Acquiring a proton charge amount of a single beam output as a first charge amount;

[0133] determining whether the first charge amount exceeds a first threshold;

[0134] The beam emission control is performed according to the determination result: if the first charge amount exceeds the first threshold value, the first safety lock is performed to prohibit the beam emission; if not, the beam emission is allowed, and the beam emission lock duration is calculated; specifically, if the first charge amount is less than or equal to the first threshold value, the beam emission is allowed once, the beam emission lock duration is determined, and the second safety lock is performed within the beam emission lock duration; wherein, during the second safety lock period, loading of the beam current is not allowed.

[0135] In some embodiments, the at least one processor is configured to obtain the beam-out locking duration in the following manner when executing the computer program:

[0136] T=N / 3600-t

[0137] Wherein, T is the beam lock time; t is the irradiation time, 3600 units are seconds, and N is the first charge amount; is the first threshold.

[0138] In some other embodiments, the at least one processor is configured to obtain the beam-out locking duration in the following manner when executing the computer program:

[0139] T=N / 3600

[0140] Wherein, T is the beam lock time; t is the irradiation time, 3600 units are seconds, and N is the first charge amount; is the first threshold.

[0141] In some other embodiments, the at least one processor is configured to obtain the beam-out locking duration in the following manner when executing the computer program:

[0142] When the first charge amount is less than the second threshold, T=T1;

[0143] When the first charge amount is greater than or equal to the second threshold and less than the third threshold, T=T2;

[0144] When the first charge amount is greater than or equal to the third threshold and less than the fourth threshold, T=T3;

[0145] Wherein, T is the beam lock duration, and T1, T2, and T3 are preset durations respectively.

[0146] In some other embodiments, the at least one processor is configured to obtain the beam-out locking duration in the following manner when executing the computer program:

[0147] T=N / 3600

[0148] Wherein, T is the beam lock time; 3600 is in seconds, and N is the first charge; is the first threshold.

[0149] The first threshold can be set according to user needs:

[0150]

[0151] in, Represents the first threshold, in coulomb (C), Indicates the preset proton flux intensity at the beam outlet, in nanoamperes (nA), and K is a coefficient (K > 0). To calculate the first threshold .

[0152] K= /

[0153] in, Set the cutting time scale for the user in hours. is the actual proton flux intensity at the beam outlet; the unit is nanoampere (nA);

[0154] According to the simulation results, When the current is 1.2 nA, the reference control level of the dose rate outside the wall is within 2.5 μSv / h. This simulation is calculated by cutting the time by one hour.

[0155] In actual applications, the device's beam port proton flow capacity can reach 35~50 nA; at the same time, different users may have different cutting time scales, which may be one and a half hours, half an hour, 20 minutes, and so on, so a coefficient K is set. According to the user's cutting time scale and the actual proton current intensity, different thresholds can be adjusted. It is determined based on the actual system performance and treatment needs to ensure the accuracy and operability of the safety lock.

[0156] The working principle and effect of the above steps are the same as those of the FLASH beam safety locking method in the embodiment, and will not be described in detail here.

[0157] An embodiment of the present application provides a FLASH treatment system, the treatment system comprising:

[0158] Radiotherapy equipment and any FLASH beam safety locking device described in the embodiments of the present application;

[0159] The radiotherapy device is used to perform radiotherapy on a patient.

[0160] An embodiment of the present application provides a computer-readable storage medium, which stores computer instructions. When a computer reads the computer instructions, the computer executes the FLASH beam safety locking method described in any one of the embodiments.

[0161] The memory 210 in this embodiment may include a readable medium in the form of a volatile memory, such as a random access memory (RAM) 211 and / or a cache memory 212 , and may further include a read-only memory (ROM) 213 .

[0162] Among them, the memory 210 also stores a computer program, which can be executed by the processor 220, so that the processor 220 executes the steps of the method in the embodiment of the present application. Its specific implementation method is consistent with the implementation method and the technical effect achieved in the embodiment of the above method, and some contents will not be repeated here.

[0163] The memory 210 may also include a utility 214 having at least one program module 215, such program module 215 including but not limited to: an operating system, one or more application programs, other program modules, and program data, each of which or some combination may include an implementation of a network environment.

[0164] Accordingly, the processor 220 may execute the above-mentioned computer program and may execute the utility 214 .

[0165] The bus 230 may be a bus representing one or more of several types of bus structures, including a memory bus or memory controller, a peripheral bus, an accelerated graphics port, a processor, or a local bus using any of a variety of bus architectures.

[0166] The electronic device 200 may also communicate with one or more external devices 240 such as keyboards, pointing devices, Bluetooth devices, etc., and may also communicate with one or more devices that can interact with the electronic device 200, and / or communicate with any device (such as a router, a modem, etc.) that enables the electronic device 200 to communicate with one or more other computing devices. This communication may be performed through an input / output interface 250. In addition, the electronic device 200 may also communicate with one or more networks (such as a local area network (LAN), a wide area network (WAN) and / or a public network, such as the Internet) through a network adapter 260. The network adapter 260 may communicate with other modules of the xxxx device 200 through a bus 230. It should be understood that, although not shown in the figure, other hardware and / or software modules may be used in conjunction with the electronic device 200, including but not limited to: microcode, device drivers, redundant processors, external disk drive arrays, RAID systems, tape drives, and data backup storage platforms, etc.

[0167] The embodiments of the present application also provide a computer-readable storage medium for storing a computer program. When the computer program is executed, the steps of the method in the embodiments of the present application are implemented. The specific implementation method is consistent with the implementation method and the technical effect achieved in the embodiments of the method, and some contents are not repeated here.

[0168] In the present application, a readable storage medium can be any tangible medium containing or storing a program, which can be used by an instruction execution system, device or device or used in combination with it. The program product 300 can adopt any combination of one or more readable media. The readable medium can be a readable signal medium or a readable storage medium. The readable storage medium can be, for example, but not limited to, a system, device or device of electricity, magnetism, light, electromagnetic, infrared, or semiconductor, or any combination of the above. More specific examples (non-exhaustive list) of readable storage media include: an electrical connection with one or more wires, a portable disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the above.

[0169] Computer-readable storage media may include data signals propagated in baseband or as part of a carrier wave, wherein readable program codes are carried. Such propagated data signals may take various forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination of the above. The readable storage medium may also be any readable medium, which may send, propagate, or transmit a program for use by an instruction execution system, an apparatus, or a device or for use in combination with it. The program code contained on the readable storage medium may be transmitted with any appropriate medium, including but not limited to wireless, wired, optical cable, RF, etc., or any suitable combination of the above. The program code for performing the operation of the present invention may be written in any combination of one or more programming languages, including object-oriented programming languages ​​such as Java, C++, etc., and also conventional procedural programming languages ​​such as C language or similar programming languages. The program code may be executed entirely on a user computing device, partially on an associated device, as an independent software package, partially on a user computing device, partially on a remote computing device, or entirely on a remote computing device or server. Where a remote computing device is involved, the remote computing device may be connected to the user computing device through any type of network, including a local area network (LAN) or a wide area network (WAN), or may be connected to an external computing device (e.g., through the Internet using an Internet service provider).

[0170] Although the embodiments of the present invention have been shown and described above, it is to be understood that the above embodiments are exemplary and are not to be construed as limitations on the present invention. A person skilled in the art may change, modify, substitute and modify the above embodiments within the scope of the invention without departing from the principles and purpose of the present invention. All such changes should fall within the scope of protection of the claims of the present invention.

Claims

1. A FLASH beam safety locking method, characterized in that: The method comprises: Acquiring a proton charge amount of a single beam output as a first charge amount; determining whether the first charge amount exceeds a first threshold; The beam emission is controlled according to the determination result: if the first charge amount exceeds the first threshold value, the first safety lock is performed to prohibit the beam emission; if not, the beam emission is allowed and the beam emission lock duration is calculated; If not, the beam is allowed to be emitted, and the beam locking time is calculated, including: if the first charge amount is less than or equal to the first threshold, the beam is allowed to be emitted once, and the beam locking time is determined, and a second safety lock is performed within the beam locking time; wherein, during the second safety lock period, loading of the beam current is not allowed; Wherein, the beam locking time is determined by the first charge amount; The first threshold includes: in, is the first threshold, is the preset proton flux intensity at the beam outlet, in nA. K is the coefficient, K>0; The coefficient K is determined by the cutting time scale, the preset proton flux intensity at the beam outlet and the actual proton flux intensity at the beam outlet.

2. The FLASH beam safety locking method according to claim 1, characterized in that: The beam lock duration is: T=N / 3600-t Wherein, T is the beam lock time; t is the irradiation time, 3600 units are seconds, and N is the first charge; is the first threshold.

3. The FLASH beam safety locking method according to claim 1, characterized in that: The beam lock duration is: T=N / 3600 Wherein, T is the beam lock time; 3600 is in seconds, and N is the first charge; is the first threshold.

4. The FLASH beam safety locking method according to claim 1, characterized in that: The beam lock duration is: When the first charge amount is less than the second threshold, T=T1; When the first charge amount is greater than or equal to the second threshold and less than the third threshold, T=T2; When the first charge amount is greater than or equal to the third threshold, T=T3; Wherein, T is the beam lock duration, and T1, T2, and T3 are preset durations respectively.

5. A FLASH beam safety locking device, characterized in that: The device comprises: Output charge quantity acquisition module: used for acquiring the proton charge quantity of a single beam output as the first charge quantity; A determination module, configured to determine whether the first charge amount exceeds a first threshold; The execution module is used to perform beam emission control according to the determination result: if the first charge amount exceeds the first threshold value, a first safety lock is performed to prohibit beam emission; if not, beam emission is allowed, and the beam emission lock time is calculated; if not, beam emission is allowed, and the beam emission lock time is calculated, including: if the first charge amount is less than or equal to the first threshold value, beam emission is allowed once, after the beam emission is once, the beam emission lock time is determined, and a second safety lock is performed within the beam emission lock time; wherein, during the second safety lock period, no beam current is loaded; The beam locking time is determined by the first charge amount; the first threshold value includes: in is the first threshold, is the preset proton flux intensity at the beam outlet, in nA. K is the coefficient, K>0; The coefficient K is determined by the cutting time scale, the preset proton flux intensity at the beam outlet and the actual proton flux intensity at the beam outlet.

6. An electronic device, characterized in that: The electronic device comprises a memory and at least one processor, the memory stores a computer program, and the at least one processor is configured to implement the following steps when executing the computer program: Acquiring a proton charge amount of a single beam output as a first charge amount; determining whether the first charge amount exceeds a first threshold; The beam emission is controlled according to the determination result: if the first charge amount exceeds the first threshold value, a first safety lock is performed to prohibit the beam emission; If not, the beam is allowed to be released, and the beam locking time is calculated; If not, the beam is allowed to be emitted, and the beam locking time length is calculated, including: if the first charge amount is less than or equal to the first threshold, the beam is allowed to be emitted once, after the beam is emitted once, the beam locking time length is determined, and a second safety lock is performed within the beam locking time length; wherein, during the second safety lock period, the beam current is not loaded; The beam locking time is determined by the first charge amount; the first threshold value includes: in is the first threshold, is the preset proton flux intensity at the beam outlet, in nA. K is the coefficient, K>0; The coefficient K is determined by the cutting time scale, the preset proton flux intensity at the beam outlet and the actual proton flux intensity at the beam outlet.

7. The electronic device according to claim 6, characterized in that: The at least one processor is configured to acquire the beam-out locking duration in the following manner when executing the computer program: T=N / 3600-t Wherein, T is the beam lock time; t is the irradiation time, 3600 units are seconds, and N is the first charge; is the first threshold.

8. The electronic device according to claim 6, characterized in that: The at least one processor is configured to acquire the beam-out locking duration in the following manner when executing the computer program: T=N / 3600 Wherein, T is the beam lock time; 3600 is in seconds, and N is the first charge; is the first threshold.

9. The electronic device according to claim 6, characterized in that: The at least one processor is configured to acquire the beam-out locking duration in the following manner when executing the computer program: When the first charge amount is less than the second threshold, T=T1; When the first charge amount is greater than or equal to the second threshold and less than the third threshold, T=T2; When the first charge amount is greater than or equal to the third threshold and less than the fourth threshold, T=T3; Wherein, T is the beam lock duration, and T1, T2, and T3 are preset durations respectively.

10. A FLASH treatment system, characterized in that: The treatment system comprises: Radiotherapy equipment and the FLASH beam safety locking device as claimed in claim 5; The radiotherapy device is used to perform radiotherapy on a patient.

11. A computer-readable storage medium, wherein the storage medium stores computer instructions, and when a computer reads the computer instructions, the computer executes the method according to any one of claims 1 to 4.

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