Magnetic particle separation device

Abstract

The present application provides a magnetic particle separation device, comprising: a magnet fixing part (2), the magnet fixing part (2) is cylindrical, and the magnet fixing part (2) is provided with a plurality of magnet mounting grooves (21); and a plurality of magnets (1), the plurality of magnets (1) are mounted in the plurality of magnet mounting grooves (21), the plurality of magnets (1) are arranged along the circumferential direction (C) of the magnet fixing part (2) to form a magnet ring, the radial inner side of the magnet ring is used to place a container, and the magnet ring is formed on its radial inner side A uniform changing magnetic field is formed which gradually increases from the center to the surroundings. The magnet ring comprises a radial magnetization magnet group (11) and a circumferential magnetization magnet group (12). The magnetization direction of the multiple magnets (1) of the radial magnetization magnet group (11) is radial, and the magnetization direction of the multiple magnets (1) of the circumferential magnetization magnet group (12) is a tangential direction of the circumference corresponding to the position of the magnet in the magnet ring. The radial magnetization magnet group (11) and the circumferential magnetization magnet group (12) are arranged alternately.

Description

Technical Field

[0001] The present application belongs to the field of biophysical therapy diagnosis technology, and in particular relates to a magnetic particle separation device. Background Art

[0002] In the field of biomedical diagnosis, magnetic particle separation devices can be used to separate magnetic particles from other components in a sample.

[0003] Chinese patent CN101208153B discloses a device and method for separating magnetic particles, which forms a non-uniform magnetic field through a magnet, but has the following disadvantages.

[0004] (1) The structure of the magnet arrangement is complex, resulting in high processing and assembly costs.

[0005] (2) If shielding measures are not taken, there is a risk of magnetic leakage. There is still a magnetic field outside the casing, which has an adverse effect on other devices such as mobile phones and watches.

[0006] (3) The magnetic field change curve is gentle, and there is a large area in the center where the magnetic field is too small, which is not conducive to the aggregation of magnetic particles.

[0007] (4) The upward protruding handle can easily break the glass container. Summary of the invention

[0008] The present application aims to provide a magnetic particle separation device to solve at least one of the above-mentioned disadvantages.

[0009] The embodiment of the present application provides a magnetic particle separation device, comprising:

[0010] A magnet fixing member, wherein the magnet fixing member is cylindrical and is provided with a plurality of magnet mounting grooves; and

[0011] A plurality of magnets are installed in the plurality of magnet installation grooves, the plurality of magnets are arranged along the circumference of the magnet fixing member to form a magnet ring, the radial inner side of the magnet ring is used to place the container, and the magnet ring forms a uniform changing magnetic field on its radial inner side that gradually increases from the center to the surroundings,

[0012] The magnet ring includes a radially magnetized magnet group and a circumferentially magnetized magnet group. The magnetization direction of the multiple magnets in the radially magnetized magnet group is radial, and the magnetization direction of the multiple magnets in the circumferentially magnetized magnet group is a tangential direction of the circumferential direction corresponding to the position of the magnet in the magnet ring. The radially magnetized magnet group and the circumferentially magnetized magnet group are arranged alternately.

[0013] In at least one possible implementation, the magnet mounting groove forms an opening at the inner periphery of the magnet fixing member, and at the inner periphery of the magnet ring, the plurality of magnets are closely attached to each other without any gaps.

[0014] In at least one possible implementation, the number of magnetic pole pairs of the magnet ring is 4.

[0015] Each of the radial magnetization magnet groups includes a plurality of magnets of the same number, and each of the circumferential magnetization magnet groups includes a plurality of magnets of the same number,

[0016] The radial magnetization magnet group and the circumferential magnetization magnet group may have the same or different numbers of magnets.

[0017] In at least one possible implementation, the radial magnetization magnet group includes a first radial magnetization magnet group, a second radial magnetization magnet group, a third radial magnetization magnet group, and a fourth radial magnetization magnet group.

[0018] The circumferential magnetization magnet group includes a first circumferential magnetization magnet group, a second circumferential magnetization magnet group, a third circumferential magnetization magnet group and a fourth circumferential magnetization magnet group.

[0019] In the clockwise direction, the first radial magnetization magnet group, the first circumferential magnetization magnet group, the second radial magnetization magnet group, the second circumferential magnetization magnet group, the third radial magnetization magnet group, the third circumferential magnetization magnet group, the fourth radial magnetization magnet group and the fourth circumferential magnetization magnet group are arranged in sequence to form a magnet ring.

[0020] The internal magnetic flux lines of the first radial magnetization magnet group and the third radial magnetization magnet group point radially inward, and the internal magnetic flux lines of the second radial magnetization magnet group and the fourth radial magnetization magnet group point radially outward,

[0021] The internal magnetic flux lines of the first circumferential magnetization magnet group and the fourth circumferential magnetization magnet group point to the first radial magnetization magnet group, and the internal magnetic flux lines of the second circumferential magnetization magnet group and the third circumferential magnetization magnet group point to the third radial magnetization magnet group.

[0022] In at least one possible implementation, in each group of the radially magnetized magnet groups, the radial dimensions of the magnets located at the edge and adjacent to the circumferentially magnetized magnet group are smaller than the radial dimensions of the remaining magnets.

[0023] In at least one possible embodiment, the magnet ring is provided with only one circle, and the cross section of the magnet is rectangular, sector-shaped or trapezoidal.

[0024] The width of the magnet along the radial direction is greater than the thickness of the magnet along the circumferential direction.

[0025] In at least one possible implementation, the magnetic particle separation device further includes a shielding cover, and the shielding cover is sleeved on the outside of the magnet ring.

[0026] In at least one possible embodiment, the magnetic particle separation device further includes a sleeve, which is disposed radially inward of the magnet fixing member, and the magnet abuts against an outer circumferential surface of the sleeve to radially position the magnet in the magnet mounting groove.

[0027] In at least one possible embodiment, the magnetic particle separation device further includes a light source, and the light source is disposed on the inner circumference of the sleeve.

[0028] In at least one possible implementation, an upper cover is connected above the magnet fixing member, and the upper cover is provided with a handle, and the handle extends radially outward from an outer periphery of the upper cover.

[0029] By adopting the above technical solution, the magnetic particle separation device of the present application can obtain at least one of the following beneficial effects.

[0030] (1) By alternating radial magnetization magnet groups and circumferential magnetization magnet groups to form a strong uniformly changing magnetic field, the magnetic particles in the magnetic field can be quickly aggregated.

[0031] (2) The shielding cover can prevent magnetic field leakage, so that the operator and the equipment he carries with him are not affected by the magnetic field.

[0032] (3) Sufficient magnetic field strength can be obtained by a circle of magnets, making it easy to set the magnetic field of the magnetic particle separation device, using fewer magnets and lowering the cost.

[0033] (4) The working area can be illuminated to facilitate observation of liquid samples in the container.

[0034] (5) The radial magnetization magnet group and the circumferential magnetization magnet group are simply arranged and easily assembled.

[0035] (6) The radial extension of the handle does not affect the taking and placing of the container. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] Figure 1 A schematic structural diagram of a magnetic particle separation device according to an embodiment of the present application is shown.

[0037] Figure 2 A cross-sectional view of a magnetic particle separation device according to an embodiment of the present application is shown.

[0038] Figure 3 A schematic structural diagram of a magnetic particle separation device (without showing the upper cover) according to an embodiment of the present application is shown.

[0039] Figure 4 A schematic diagram of the internal structure of a magnetic particle separation device according to an embodiment of the present application is shown.

[0040] Figure 5 A schematic structural diagram of a magnet fixing device for separating magnetic particles according to an embodiment of the present application is shown.

[0041] Figure 6 A schematic structural diagram of a magnet ring of a magnetic particle separation device according to an embodiment of the present application is shown.

[0042] Figure 7 A schematic structural diagram of a magnet ring of a magnetic particle separation device according to another embodiment of the present application is shown.

[0043] Figure 8 FIG. 4 shows a curve of magnetic field variation along the X-axis direction in the working area of ​​the magnetic particle separation device according to an embodiment of the present application.

[0044] Fig. 9 FIG. 4 shows a curve of magnetic field variation along the Y-axis direction in the working area of ​​the magnetic particle separation device according to an embodiment of the present application.

[0045] Fig.10 The figure shows the magnetic field variation curve in the working area of ​​the magnetic particle separation device according to the embodiment of the present application along the direction with an angle of 45 degrees with the X-axis and the Y-axis.

[0046] Description of Reference Numerals

[0047] 1 Magnet

[0048] 11 radial magnetization magnet group 111 first radial magnetization magnet group 112 second radial magnetization magnet group 113 third radial magnetization magnet group 114 fourth radial magnetization magnet group

[0049] 12 Circumferential magnetization magnet group 121 First circumferential magnetization magnet group 122 Second circumferential magnetization magnet group 123 The third circumferential magnetization magnet group 124 The fourth circumferential magnetization magnet group

[0050] 2 Magnet fixing piece 21 Magnet mounting slot 22 Wire slot

[0051] 3 Shielding cover 31 Shielding cover peripheral wall 32 Shielding cover top wall

[0052] 4 End cover 41 Upper end cover 42 Lower end cover

[0053] 5 Sleeve

[0054] 6 Shell 61 Shell peripheral wall 62 Shell bottom wall

[0055] 7 Upper cover 71 Handle 711 Groove 72 Switch mounting hole

[0056] 8 Base 81 Battery compartment

[0057] A Axial C Circumferential DETAILED DESCRIPTION

[0058] In order to more clearly explain the above-mentioned purposes, features and advantages of the present application, the specific implementation methods of the present application are described in detail in this section in conjunction with the accompanying drawings. In addition to the various implementation methods described in this section, the present application can also be implemented in other different ways. Without violating the spirit of the present application, those skilled in the art can make corresponding improvements, deformations and substitutions, so the present application is not limited by the specific embodiments disclosed in this section. The scope of protection of the present application shall be subject to the claims.

[0059] like Figures 1 to 10 As shown, an embodiment of the present application provides a magnetic particle separation device, which includes a plurality of magnets 1, a magnet fixing member 2, a shielding cover 3, an end cover 4, a sleeve 5, a shell 6 and an upper cover 7.

[0060] like Figures 2 to 5 As shown, the magnet fixing part 2 may be cylindrical, and the magnet fixing part 2 is provided with a magnet mounting groove 21, and the magnet mounting groove 21 may be provided at the inner circumference of the magnet fixing part 2, and the magnet mounting groove 21 forms an opening at the inner circumference of the magnet fixing part 2. A plurality of magnet mounting grooves 21 may be provided along the circumferential direction C of the magnet fixing part 2.

[0061] A wire groove 22 may be provided on the outer periphery of the magnet fixture 2 . The wire groove 22 may extend along the axial direction A of the magnet fixture 2 . The wire groove 22 is used to accommodate cables.

[0062] A plurality of magnets 1 can be embedded in the magnet mounting groove 21, and the plurality of magnets 1 are arranged along the circumferential direction C of the magnet fixing member 2 to form a magnet ring. A uniformly changing magnetic field can be formed on the radial inner side of the magnet ring, and the plurality of magnets 1 are arranged in a Halbach array, so that the magnet ring forms a uniformly changing magnetic field on its radial inner side that gradually increases from the center to the surroundings.

[0063] Figure 6 and Figure 7 The one-way arrow in the figure indicates the direction of the magnetic flux lines inside the magnet 1 (the magnetization direction of the magnet), and the magnetic flux lines point from the S pole to the N pole inside the magnet.

[0064] like Figure 6 and Figure 7As shown, the number of magnetic pole pairs P of the magnet ring may be an integer greater than or equal to 2. In this embodiment, the number of magnetic pole pairs P of the magnet ring may be 4, and the magnet ring has a total of 8 groups of magnets 1. The magnetization directions of the multiple magnets 1 in the same group are substantially the same.

[0065] The magnet ring includes a radial magnetization magnet group 11 and a circumferential magnetization magnet group 12. The magnets of the radial magnetization magnet group 11 can be magnetized along the radial direction of the magnet fixture 2, and the magnets of the circumferential magnetization magnet group 12 can be magnetized along the circumferential direction C of the magnet fixture 2. The radial magnetization magnet group 11 and the circumferential magnetization magnet group 12 are alternately arranged to form a strong uniformly changing magnetic field.

[0066] The magnetization directions of the multiple magnets in the radial magnetization magnet group 11 are substantially the same, but not completely the same, and the magnetization direction of each magnet 1 in the radial magnetization magnet group 11 is radial. The magnetization directions of the multiple magnets in the circumferential magnetization magnet group 12 are substantially the same, but not completely the same, and the magnetization direction of each magnet 1 in the circumferential magnetization magnet group 12 is the circumferential direction (or the tangential direction of the circumferential direction) of the position of the magnet in the magnet ring.

[0067] like Figure 6 As shown, the radial magnetization magnet group 11 includes a first radial magnetization magnet group 111 , a second radial magnetization magnet group 112 , a third radial magnetization magnet group 113 and a fourth radial magnetization magnet group 114 .

[0068] The circumferentially magnetized magnet group 12 includes a first circumferentially magnetized magnet group 121 , a second circumferentially magnetized magnet group 122 , a third circumferentially magnetized magnet group 123 and a fourth circumferentially magnetized magnet group 124 .

[0069] In the clockwise direction, the first radial magnetization magnet group 111, the first circumferential magnetization magnet group 121, the second radial magnetization magnet group 112, the second circumferential magnetization magnet group 122, the third radial magnetization magnet group 113, the third circumferential magnetization magnet group 123, the fourth radial magnetization magnet group 114 and the fourth circumferential magnetization magnet group 124 are arranged in sequence to form a magnet ring.

[0070] In this embodiment, the internal magnetic flux lines of the first radial magnetization magnet group 111 and the third radial magnetization magnet group 113 point radially inward, and the internal magnetic flux lines of the second radial magnetization magnet group 112 and the fourth radial magnetization magnet group 114 point radially outward. The internal magnetic flux lines of the first circumferential magnetization magnet group 121 and the fourth circumferential magnetization magnet group 124 point to the first radial magnetization magnet group 111, and the internal magnetic flux lines of the second circumferential magnetization magnet group 122 and the third circumferential magnetization magnet group 123 point to the third radial magnetization magnet group 113.

[0071] Each radial magnetization magnet group 11 and each circumferential magnetization magnet group 12 includes a plurality of magnets, and the plurality of magnets can make the magnetization direction of each radial magnetization magnet group 11 as radial as possible, and the plurality of magnets can make the overall magnetization direction of the circumferential magnetization magnet group 12 as close to an arc as possible rather than a straight line. The number of magnets in each radial magnetization magnet group 11 and the number of magnets in each circumferential magnetization magnet group 12 can be the same, for example, the number of magnets in each radial magnetization magnet group 11 and each circumferential magnetization magnet group 12 are both 6. That is, the magnetic particle separation device can have 8 groups, each group has 6 magnets 1, and a total of 48 magnets 1.

[0072] The width of the magnet 1 along the radial direction may be greater than the thickness along the circumferential direction C. For example, the width of the magnet 1 may be greater than or equal to 1.5 times the thickness and less than 5 times the thickness. The greater the width of the magnet 1 along the radial direction, the higher the magnetic field strength formed, and the smaller the thickness of the magnet 1 along the circumferential direction C, the better the uniformity of the magnetic field formed along the circumferential direction C. The ratio of the width and thickness of the magnet can be adjusted according to specific design requirements.

[0073] The magnet ring formed by the above magnet arrangement only needs one circle to obtain sufficient magnetic field strength, so that the magnetic field of the magnetic particle separation device is easy to set, the number of magnets used is small, and the cost is low.

[0074] In other possible embodiments, the number of magnets in the radial magnetization magnet group 11 and the circumferential magnetization magnet group 12 may be different. For example, each radial magnetization magnet group 11 may include 5 magnets, and each circumferential magnetization magnet group 12 may include 4 magnets, so the magnetic particle separation device may have 36 magnets 1. Of course, each radial magnetization magnet group 11 may include 4 magnets, and each circumferential magnetization magnet group 12 may include 5 magnets.

[0075] Optionally, the radial size of the magnets located at the edge of each radial magnetization magnet group 11 and adjacent to the circumferential magnetization magnet group 12 can be smaller than the radial size of the remaining magnets 1, so that the magnetic field strengths of the parts with the same radial position in the working area can be roughly the same at various locations in the circumferential direction. It can be understood that the radial width or thickness along the circumferential direction C of the magnets at other positions can also be adjusted according to specific needs, and the magnets at different positions can have different sizes or shapes.

[0076] It can be understood that the dimensions of the magnet mounting grooves 21 accommodating the magnets 1 with smaller radial dimensions can be correspondingly smaller than the depth of the remaining magnet mounting grooves 21 .

[0077] In the inner circumference of the magnet ring, the multiple magnets 1 constituting the magnet ring can be closely attached to each other without gaps, which helps to make the magnetic field strengths of the parts with the same radial position in the working area roughly the same at all places in the circumferential direction. It can be understood that this is only an exemplary embodiment and is not restrictive. Even if there are gaps between the multiple magnets in the inner circumference of the magnet ring, a strong uniformly changing magnetic field can be formed.

[0078] like Figure 6 As shown, the cross section of the magnet can be rectangular, and the manufacturing cost of the magnet with a rectangular cross section is low. In other possible embodiments, such as Figure 7 As shown, the cross section of the magnet may also be sector-shaped or trapezoidal.

[0079] like Figures 2 to 4 As shown, the end caps 4 are mounted at both axial ends of the magnet fixture 2, and the end caps 4 include an upper end cap 41 and a lower end cap 42. The upper end cap 41 can be connected to the upper end of the magnet fixture 2 by a fastener such as a bolt, and the lower end cap 42 can be connected to the lower end of the magnet fixture 2 by a fastener such as a bolt. The lower end cap 42 can be used to place a container, and the container is located radially inside the sleeve 5. The space for placing the container can be called a working area, and the sample to be separated can be placed in the container.

[0080] The sleeve 5 may be cylindrical, and may be disposed in the hollow area of ​​the magnet fixing member 2. The axial ends of the sleeve 5 may be connected to the end caps 4, the upper end of the sleeve 5 may be connected to the upper end cap 41, and the lower end of the sleeve 5 may be connected to the lower end cap 42. The sleeve 5 is located radially inward of the magnet 1, and the radial inner portion of the magnet 1 may abut against the outer circumferential surface of the sleeve 5, so that the magnet 1 is radially positioned in the magnet mounting groove 21 and will not fall out.

[0081] The upper cover 7 can be connected to the upper end cover 41, and the outer periphery of the upper cover 7 can be provided with a handle 71 protruding radially outward, and the lower part of the handle 71 can be provided with a groove 711, or the handle 71 can be provided with a hollow, so that fingers can be inserted into the groove 711 or the hollow to hook the handle 71, thereby facilitating the movement of the magnetic particle separation device.

[0082] A light source such as an LED light strip may be provided on the inner periphery of the sleeve 5. Optionally, the light source is located at the lower end of the sleeve 5, and the working area can be illuminated by the light source, so as to facilitate observation of the liquid sample (such as blood) in the container.

[0083] like Figure 2 and Figure 3 As shown, the shielding cover 3 is sleeved on the outside of the magnet ring, and the shielding cover 3 may include a shielding cover peripheral wall 31 and a shielding cover top wall 32. The shielding cover peripheral wall 31 may be sleeved on the outer periphery of the magnet fixing part 2, and the shielding cover top wall 32 may be connected to the upper end cover 41. The shielding cover top wall 32 is located above the magnet ring.

[0084] The shielding cover 3 can be made of ferromagnetic materials such as iron. The shielding cover 3 can prevent the magnetic field from escaping from the upper side and surrounding sides of the magnetic particle separation device and affecting the space outside the working area of ​​the magnetic particle separation device. For example, the shielding cover can prevent the operator and his / her watches, mobile phones, etc. from being affected by the magnetic field of the magnetic particle separation device.

[0085] It is understood that in other possible implementations, the shielding cover 3 may further include a shielding cover bottom wall (not shown in the figure), which may be connected to the lower end cover and may shield the magnetic field from escaping downward from the working area.

[0086] The base 8 can be connected to the lower end cover 42, and the base 8 can be provided with a battery compartment 81 and a control board. The battery compartment 81 can accommodate batteries, and the batteries can power the light source. The battery compartment 81 can be provided with a pole piece, and the positive and negative poles of the battery installed in the battery compartment 81 can contact the pole piece, and the light source and the pole piece can be electrically connected to the control board. The control board can be connected to the switch button through a cable, and the upper cover 7 can be provided with a switch mounting hole 72, and the switch button is installed in the switch mounting hole 72. The light source can be turned on or off by operating the switch button.

[0087] like Figure 2 As shown, the shell 6 may include a shell peripheral wall 61 and a shell bottom wall 62 . The shell peripheral wall 61 may be disposed on the outer periphery of the shielding cover peripheral wall 31 , and the shell bottom wall 62 may be disposed below the base 8 .

[0088] Reference Figures 8 to 10 , for example, at a magnetic field strength of less than 0.1 Tesla, the speed of magnetization aggregation of magnetic particles in the magnetic field is significantly reduced, so the area with lower magnetic field strength should not be too large. In the embodiment of the present application, the diameter range corresponding to the magnetic field strength of 0.1 Tesla is 18 mm, the curve of magnetic field growth is relatively steep, and the area with lower magnetic field strength is smaller.

[0089] exist Figures 8 to 10 In the figure, the horizontal axis represents the radius from the center of the working area (in millimeters), and the vertical axis represents the magnetic field strength (in millitesla).

[0090] like Figure 8 As shown, in the X-axis direction, from the center of the magnet fixture to the outside, the magnetic field strength increases gradually without a sudden change.

[0091] like Fig. 9 As shown, in the Y-axis direction, from the center of the magnet fixture to the outside, the magnetic field strength increases gradually without a sudden change.

[0092] like Fig.10As shown, in the direction where the angles with the X-axis and the Y-axis are both 45 degrees, the magnetic field strength increases gradually from the center of the magnet fixture to the outside, and there is no sudden change.

[0093] It can be understood that at a position far from the center of the working area and close to the sleeve 5, the magnitude of the magnetic field will not affect the magnetic particles, because this position corresponds to the gap between the container and the sleeve 5, and there are no magnetic particles.

[0094] The magnetic particle separation device of the present application can achieve the following beneficial effects.

[0095] (1) By alternately arranging the radial magnetization magnet group 11 and the circumferential magnetization magnet group 12, a strong uniformly changing magnetic field is formed, which can make the magnetic particles in the magnetic field gather quickly.

[0096] (2) The shielding cover can prevent magnetic field leakage, so that the operator and the equipment he carries with him are not affected by the magnetic field.

[0097] (3) Sufficient magnetic field strength can be obtained by a circle of magnets, making it easy to set the magnetic field of the magnetic particle separation device, using fewer magnets and lowering the cost.

[0098] (4) The working area can be illuminated to facilitate observation of liquid samples in the container.

[0099] (5) The radial magnetization magnet group 11 and the circumferential magnetization magnet group 12 are simply arranged and easily assembled.

[0100] (6) The radial extension of the handle does not affect the taking and placing of the container.

[0101] It should be understood that at least some aspects or features of the above-mentioned implementation modes, embodiments or examples may be appropriately combined.

[0102] It is understood that in the present application, when the number of parts or components is not particularly limited, the number may be one or more, and the multiple here means two or more. For the case where the number of parts or components shown in the drawings and / or described in the specification is a specific number such as two, three, four, etc., the specific number is usually exemplary and not restrictive, and it can be understood as multiple, that is, two or more, but this does not mean that the present application excludes the case of one.

[0103] In the present application, unless otherwise clearly stated or limited, the terms such as "install", "assemble", "assemble", "connect", "connect", "couple", "link", "abut", "connect", "interconnect", "intercommunication", "conduction", "fixation", "fastening" and the like should be understood in a broad sense, for example, they can be direct or indirect. For example, regarding connection, it can be a fixed connection, a detachable connection, or an integral one; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly stated or limited. For example, regarding connectivity / conduction, it can be direct connectivity / conduction, or it can be indirect connectivity / conduction via an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to the specific circumstances.

[0104] In the present application, unless otherwise clearly stated or limited, a component disposed on / installed on / located on / accommodated on / placed in, within, inside, etc. another component may be any of the following two situations: a part or most of the one component is located in the other component; and the one component is completely accommodated in the other component.

[0105] Although the present application is described in detail using the above-mentioned embodiments, it is obvious to those skilled in the art that the present application is not limited to the embodiments described in this specification. The present application can be modified and implemented as a modified embodiment without departing from the subject matter and scope of the present application as determined by the claims. Therefore, the description in this specification is for the purpose of illustration and does not have any restrictive meaning for the present application.

Claims

1. A magnetic particle separation device, characterized in that: include: A magnet fixing member (2), the magnet fixing member (2) being cylindrical and provided with a plurality of magnet mounting grooves (21); as well as A plurality of magnets (1), the plurality of magnets (1) being mounted in the plurality of magnet mounting grooves (21), the plurality of magnets (1) being arranged along the circumferential direction (C) of the magnet fixing member (2) to form a magnet ring, the radial inner side of the magnet ring being used to place a container, the magnet ring forming a uniformly changing magnetic field on its radial inner side that gradually increases from the center to the periphery, The magnet ring comprises a radial magnetization magnet group (11) and a circumferential magnetization magnet group (12); the magnetization direction of the plurality of magnets (1) of the radial magnetization magnet group (11) is radial, and the magnetization direction of the plurality of magnets (1) of the circumferential magnetization magnet group (12) is a tangential direction of the circumference corresponding to the position of the magnet in the magnet ring; the radial magnetization magnet group (11) and the circumferential magnetization magnet group (12) are arranged alternately. The magnet mounting groove (21) forms an opening at the inner periphery of the magnet fixing member (2), and at the inner periphery of the magnet ring, the plurality of magnets (1) are closely attached to each other without any gap.

2. The magnetic particle separation device according to claim 1, characterized in that: The number of magnetic pole pairs of the magnet ring is 4. Each of the radially magnetized magnet groups (11) includes a plurality of magnets of the same number, and each of the circumferentially magnetized magnet groups (12) includes a plurality of magnets of the same number, The number of magnets in the radial magnetization magnet group (11) and the number of magnets in the circumferential magnetization magnet group (12) are the same or different.

3. The magnetic particle separation device according to claim 1, characterized in that: The radial magnetization magnet group (11) comprises a first radial magnetization magnet group (111), a second radial magnetization magnet group (112), a third radial magnetization magnet group (113) and a fourth radial magnetization magnet group (114). The circumferentially magnetized magnet group (12) comprises a first circumferentially magnetized magnet group (121), a second circumferentially magnetized magnet group (122), a third circumferentially magnetized magnet group (123) and a fourth circumferentially magnetized magnet group (124). In a clockwise direction, the first radial magnetization magnet group (111), the first circumferential magnetization magnet group (121), the second radial magnetization magnet group (112), the second circumferential magnetization magnet group (122), the third radial magnetization magnet group (113), the third circumferential magnetization magnet group (123), the fourth radial magnetization magnet group (114), and the fourth circumferential magnetization magnet group (124) are arranged in sequence to form a magnet ring. The internal magnetic flux lines of the first radial magnetization magnet group (111) and the third radial magnetization magnet group (113) point radially inward, and the internal magnetic flux lines of the second radial magnetization magnet group (112) and the fourth radial magnetization magnet group (114) point radially outward. The internal magnetic flux lines of the first circumferential magnetizing magnet group (121) and the fourth circumferential magnetizing magnet group (124) point toward the first radial magnetizing magnet group (111), and the internal magnetic flux lines of the second circumferential magnetizing magnet group (122) and the third circumferential magnetizing magnet group (123) point toward the third radial magnetizing magnet group (113).

4. The magnetic particle separation device according to claim 1, characterized in that: The radial dimensions of the magnets (1) located at the edge of each radial magnetization magnet group (11) and adjacent to the circumferential magnetization magnet group (12) are smaller than the radial dimensions of the remaining magnets (1).

5. The magnetic particle separation device according to claim 1, characterized in that: The magnet ring is provided with only one circle, and the cross section of the magnet (1) is rectangular, sector-shaped or trapezoidal. The width of the magnet (1) along the radial direction is greater than the thickness along the circumferential direction.

6. The magnetic particle separation device according to claim 1, characterized in that: The magnetic particle separation device further comprises a shielding cover (3), wherein the shielding cover (3) is sleeved on the outside of the magnetic ring.

7. The magnetic particle separation device according to claim 1, characterized in that: The magnetic particle separation device further comprises a sleeve (5), wherein the sleeve (5) is arranged radially inside the magnet fixing member (2), and the magnet (1) abuts against the outer peripheral surface of the sleeve (5), so that the magnet (1) is radially positioned in the magnet mounting groove (21).

8. The magnetic particle separation device according to claim 7, characterized in that: The magnetic particle separation device further comprises a light source, which is arranged on the inner periphery of the sleeve (5).

9. The magnetic particle separation device according to claim 1, characterized in that: An upper cover (7) is connected above the magnet fixing member (2), and the upper cover (7) is provided with a handle (71), and the handle (71) extends radially outward from the outer periphery of the upper cover (7).

Images