Yin nourishing composition, preparation method and application

Abstract

The present invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a yin nourishing composition, a preparation method and an application. The yin nourishing composition comprises donkey-hide gelatin, tortoise shell glue, polygonatum, ophiopogon japonicus, tangerine peel and Poria cocos. The preparation method comprises extracting tangerine peel, polygonatum, ophiopogon japonicus and Poria cocos, and then mixing the extract, donkey-hide gelatin and tortoise shell glue. Under the guidance of traditional Chinese medicine theory, this prescription is used to nourish yin and blood, and has the effects of moisturizing and beautifying. It has the effects of promoting cell regeneration, promoting hematopoiesis, metabolic function, enhancing the body's immune function, improving the body's adaptability, and preventing and treating progressive muscular dystrophy; it can also promote calcium metabolism, anti-oxidation, etc., and has great value for the nutritional health care of the skin, and can prevent wrinkles, prevent skin aging, and resist fatigue.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a yin-nourishing composition, a preparation method and an application thereof. Background Art

[0002] Yin deficiency and hyperactivity of fire refers to the deficiency of yin in the internal organs, lack of nourishment, and endogenous heat. This can occur in the heart, liver, lungs, spleen, and kidneys. Clinically, kidney yin deficiency is more common, with symptoms including hot flashes, night sweats, irritability, insomnia, premature ejaculation and spermatorrhea in men, oligomenorrhea or amenorrhea in women, or bone steaming fever, soreness of waist and knees, tinnitus, etc.

[0003] Yin deficiency often develops slowly and lasts a long time. Its main clinical features include fever in the five parts of the body, red cheeks in the afternoon, insomnia, night sweats, dry mouth and throat, dizziness, tinnitus, red tongue with little coating, and weak pulse. The main function of Yin, in addition to nourishing and moistening the organs and tissues, is to restrain Yang to prevent it from being exposed. Yang is characterized by heat, movement, and ascending, while Yin is characterized by cold, stillness, and descending. If Yin is deficient and unable to restrain Yang, the human body will experience a state of deficiency heat with excessive Yang, the so-called "Yin deficiency produces internal heat". The "Inner Canon of Medicine" states: "After the age of forty, Yin is half gone." As we age, or after a fever, or have excessive sexual intercourse, it is easy to consume the true Yin.

[0004] Chinese invention patent application CN201910290200.8 discloses a paste prescription for conditioning physical condition and its preparation method, the raw materials include: Radix Rehmanniae, Chinese yam, Chinese wolfberry, Fructus Corni, Achyranthes bidentata, Cuscuta australis, Millettia spatholobi, Rhodiola rosea, Acanthopanax senticosus, Gynostemma pentaphyllum, Poria, Astragalus, Cinnamon twig, Aconite root, Ginseng, Polygonatum odoratum, Cinnamon bark, Dried ginger, Eucommia bark, Dipsacus asper, Viscum album, Ophiopogon japonicus, Adenophora australis, Schisandra chinensis, Angelica sinensis, Shenqu, Forsythia suspensa, Roasted Licorice, Rhizoma Chuanxiong, Red Peony Root, White Peony Root, Tangerine Peel, Roasted Malt, Magnolia officinalis, Atractylodes macrocephala, Citrus aurantium, Apricot kernel, Bupleurum chinense, Roasted Scutellaria baicalensis, Saposhnikovia divaricata, Salt Plantago asiatica, Platycodon grandiflorum, Peony bark, Peach kernel, Ejiao, Deer antler glue, Tortoise shell glue, Jujube, Honey, Rock sugar, Yellow wine. The preparation method includes: 1) Soaking; 2) Crushing; 3) Making paste. The paste for conditioning the physical constitution of the present invention can condition the physical constitution of elderly patients, treat various symptoms of weakness caused by deficiency of qi, blood, yin and yang of viscera, and internal obstruction of phlegm and blood stasis, and improve the quality of life of elderly patients.

[0005] The prior art has disclosed some yin-nourishing Chinese medicines and achieved certain results, but overall there is still room for improvement. In addition, some of the medicines have many complex flavors, poor clinical compliance, and are not convenient for studying the material basis of the efficacy, and it is not easy to control the body's reactions other than nourishing yin. Summary of the invention

[0006] In view of the deficiencies in the prior art, the present invention provides a Yin-nourishing composition, a preparation method and an application thereof.

[0007] In order to achieve the purpose of the present invention, the technical solution adopted is as follows:

[0008] A yin nourishing composition, comprising donkey-hide gelatin, tortoise shell glue, polygonatum, ophiopogon japonicus, tangerine peel and tuckahoe.

[0009] Preferably, the Yin nourishing composition comprises, by weight, 1-7 parts of donkey-hide gelatin, 3-7 parts of tortoise shell glue, 3-7 parts of polygonatum, 3-7 parts of ophiopogon, 1-4 parts of tangerine peel, and 3-7 parts of poria.

[0010] Donkey hide gelatin was first recorded in Shennong's Herbal Classic and was listed as a top grade product. Mingyi Bielu records: "Donkey hide gelatin is produced in Dongping County (now Dongping County, Shandong Province), and is made by boiling cow hide, and is produced in Dong'e County." The Materia Medica Illustrated Classic says: "Now Yunzhou can make it. The real one is boiled with the water from the well in the north of A County. To make it, boil black donkey hide with A well water, just like boiling gelatin. The well is forbidden by the government, and the real gelatin is extremely rare. It has the effects of nourishing blood, stopping bleeding, nourishing yin and moistening dryness.

[0011] Turtle shell glue can nourish yin, blood and stop bleeding. It is used for yin deficiency, hot flashes, bone steaming, night sweats, soreness of waist and knees, blood deficiency, sallow complexion, metrorrhagia and leucorrhea.

[0012] Polygonatum sibiricum has the effects of treating yin deficiency and fatigue cough, lung dryness and cough, spleen deficiency and fatigue, loss of appetite and dry mouth, kidney deficiency, soreness of waist and knees, impotence and spermatorrhea, tinnitus, blurred vision, and premature graying of hair.

[0013] Poria cocos is sweet, mild and flat in nature, and enters the heart, lung and spleen meridians. It has the effects of penetrating dampness and promoting diuresis, strengthening the spleen and stomach, and calming the mind.

[0014] Ophiopogon japonicus is sweet, cold and refreshing. It is good at clearing heat from the heart and lungs, nourishing yin and relieving restlessness. It can also clear the stomach and intestines, quench thirst and relieve dryness.

[0015] Tangerine peel is warm in nature, pungent and bitter in taste. It enters the spleen meridian, stomach meridian and lung meridian. It has the functions of regulating qi and strengthening the spleen, regulating the middle, drying dampness and resolving phlegm. It is mainly used to treat abdominal distension or pain caused by spleen and stomach qi stagnation, indigestion, chest tightness, abdominal distension, poor appetite and loose stools caused by dampness and turbidity blocking the middle.

[0016] Modern research has shown that donkey-hide gelatin and tortoise shell glue mainly contain gelatin protein formed by the hydrolysis of collagen, which produces various amino acids after hydrolysis. They interact and combine with each other in the body to produce a variety of enzymes and vitamins that are beneficial to the human body; Polygonatum sibiricum contains a large amount of acids, quinones, and polysaccharides, which have the effects of lowering blood pressure, lowering blood sugar, lowering blood lipids, preventing atherosclerosis, resisting fatigue, anti-oxidation, delaying aging and anti-bacterial, and Polygonatum sibiricum polysaccharide has an immune activation effect; Ophiopogon japonicus contains a variety of steroidal saponins, which can improve immune function, have an inhibitory effect on a variety of bacteria, can enhance the function of the pituitary adrenal cortex system, and improve It has high body adaptability, has the effects of anti-arrhythmia and dilating peripheral blood vessels, can improve the ability to tolerate hypoxia, and has the effects of lowering blood sugar; Tangerine peel contains volatile oils, hesperidin, vitamins B and C and other ingredients. The volatile oil it contains has a mild stimulating effect on the gastrointestinal tract, can promote the secretion of digestive juice, eliminate gas accumulation in the intestine, and increase appetite; Poria mainly contains Poria polysaccharide, which has obvious anti-tumor effects, can enhance the body's immune function, has a diuretic effect, can increase the excretion of electrolytes such as potassium, sodium, and chloride in the urine, has sedative and liver protection, inhibits the occurrence of ulcers, lowers blood sugar, and has anti-radiation effects.

[0017] Another object of the present invention is to provide a method for preparing the above-mentioned Yin-nourishing composition, comprising the following steps:

[0018] Extract dried tangerine peel, polygonatum, ophiopogon japonicus and poria cocos, and then mix the extracted extracts, donkey-hide gelatin and tortoise shell glue to obtain the product.

[0019] Preferably, the extraction is performed by adding 8-12 times the amount of water for 1-3 times, and the time for each extraction is 1-3 hours; preferably, the extraction is performed by adding 10 times the amount of water for 2 times, and the time for each extraction is 2 hours.

[0020] Preferably, the preparation method of the above-mentioned Yin nourishing composition comprises the following steps:

[0021] (1) First, add 8-12 times the amount of water to the dried tangerine peel and boil it to extract the volatile oil and the residue;

[0022] (2) extracting the medicinal residue, polygonatum sibiricum, ophiopogon japonicus and poria cocos, filtering and obtaining a filtrate;

[0023] (3) Then mix the filtrate, donkey-hide gelatin and tortoise shell glue, and then add volatile oil to obtain the product.

[0024] Preferably, the mixing is to add donkey-hide gelatin and tortoise shell glue to the extract and melt them, or to melt the donkey-hide gelatin and tortoise shell glue first and then mix them with the extract.

[0025] Preferably, the melting temperature is 80-90°C;

[0026] And / or, the melting is also carried out by adding rice wine or water.

[0027] And / or, after the mixing, the mixture is centrifuged at 3000-5000 r / min for 20-50 min and filtered to obtain the product.

[0028] Another object of the present invention is to provide a pharmaceutical preparation, comprising a Yin-nourishing composition and pharmaceutically acceptable excipients, wherein the preparation is in the form of an oral preparation.

[0029] Preferably, the preparation is in the form of a nourishing yin paste, and the auxiliary material is one or more of honey, ginger juice, lemon juice, jujube juice, and rice wine;

[0030] Preferably, the method for preparing the nourishing yin paste comprises:

[0031] (1) adding honey to the rest of the Yin-nourishing composition except for the volatile oil of dried tangerine peel at a weight ratio of 1:1;

[0032] (2) Finally, add tangerine peel volatile oil, or add ginger juice, lemon juice, and jujube juice, heat in a water bath for 1 hour, stir well, fill, and sterilize to obtain the Yin-nourishing paste.

[0033] Or, the dosage form of the preparation is an oral solution, and the auxiliary material is jujube juice;

[0034] Preferably, the oral solution is prepared by:

[0035] Add water to the Yin-nourishing composition to prepare a solution, the volume of the solution and the total mass of the medicinal materials being 1 ml:2.5 g, stirring for 15 min, adding an appropriate amount of jujube juice, stirring for another 10 min, filtering, filling, 100 ml per bottle, sterilizing at 105°C for 30 min, and obtaining the product.

[0036] Alternatively, the dosage form of the preparation is granules, and the auxiliary material is powdered sugar.

[0037] Preferably, the granule preparation method comprises:

[0038] The Yin-nourishing composition is concentrated to a relative density of 1.1-1.2, and auxiliary materials are added and mixed, granulated through a 10-30 mesh sieve, dried at 60-80° C. for 0.5-2 hours, granulated through a 10 mesh sieve, sprayed with volatile oil, and packaged.

[0039] Another object of the present invention is to provide a Yin-nourishing composition or an application of the Yin-nourishing composition prepared by the above-mentioned preparation method in the preparation of a drug for preventing and treating Yin deficiency.

[0040] Compared with the prior art, the present invention has the following beneficial effects:

[0041] (1) The present invention is a medicine or health food with the function of nourishing Yin. It can prevent the occurrence of Yin deficiency symptoms and relieve Yin deficiency syndrome, and can also regulate the adverse symptoms that have already occurred, thus achieving the effect of health care or treatment.

[0042] (2) This prescription is guided by the theory of traditional Chinese medicine. Turtle shell glue nourishes yin, nourishes blood, and stops bleeding, while donkey-hide gelatin nourishes blood, stops bleeding, nourishes yin and moistens dryness. It is the main medicine; Polygonatum sibiricum nourishes qi and nourishes yin, and Ophiopogon japonicus moistens the lungs and nourishes yin. It is the assistant medicine; Tangerine peel has the functions of regulating qi and strengthening the spleen, drying dampness and resolving phlegm, and Poria cocos has the functions of promoting diuresis, penetrating dampness, strengthening the spleen, and calming the mind. It is the adjuvant medicine. The prescription and the combination of drugs can nourish yin and blood, and have the effects of moistening dryness and beautifying. The formula has the functions of promoting cell regeneration, promoting hematopoiesis and metabolic function, enhancing the body's immune function, and resisting fatigue.

[0043] (3) In the composition of the present invention, polygonatum sibiricum and tangerine peel have a strong synergistic effect in nourishing blood and relieving physical fatigue. DETAILED DESCRIPTION

[0044] The present invention is further described below in conjunction with specific embodiments. The raw materials in the following examples are all commercially available conventional raw materials.

[0045] The raw materials and auxiliary materials used in the present invention should comply with the provisions of the corresponding varieties in the Pharmacopoeia of the People's Republic of China (2010 edition). Honey should comply with the provisions of GB 14963-2011. The following parts are weight parts, and each weight part is 100g.

[0046] Embodiment 1:

[0047] First, take 4 parts of dried tangerine peel, add 5 times the amount of water, and extract volatile oil by steam distillation. Mix the residue with 7 parts of polygonatum, 7 parts of ophiopogon, and 7 parts of poria, add 10 times the amount of water to extract twice, each time for 1.5 hours, filter, combine the filtrate, and concentrate. Then add 5 parts of donkey-hide gelatin and 7 parts of tortoise shell glue, melt, mix well, centrifuge at 4000r / min for 30 minutes, and add honey at a weight ratio of 1:1. Finally, add volatile oil from dried tangerine peel, stir well, fill, and sterilize to obtain the nourishing yin paste.

[0048] Embodiment 2:

[0049] First, take 4 parts of dried tangerine peel, 6 parts of polygonatum, 6 parts of ophiopogon, and 6 parts of poria, add 5 times the amount of water, reflux the water vapor to extract the volatile oil, add 10 times the amount of water to extract the residue twice, each time for 1.5 hours, filter, combine the filtrate, and concentrate. Then add 5 parts of donkey-hide gelatin and 7 parts of tortoise shell glue, melt, mix, centrifuge at 4000r / min for 30 minutes, and add honey at a weight ratio of 1:1. Finally, add the volatile oil, stir well, fill, and sterilize to obtain the nourishing yin paste.

[0050] Embodiment 3:

[0051] Take 4 parts of dried tangerine peel, add 5 times the amount of water, extract volatile oil by steam distillation, mix the residue with 5 parts of polygonatum, 5 parts of ophiopogon, and 5 parts of tuckahoe, add 8 times the amount of water to extract twice, each time for 2 hours, filter, combine the filtrate, and concentrate. Then take 3 parts of donkey-hide gelatin and 5 parts of tortoise shell glue, add the same amount of purified water, sterilize in a water bath at 80℃, and filter. After mixing the above two parts, filter the plate and frame to obtain the filtrate, add water to 1000mL, stir for 15min, add 4 parts of jujube juice, stir for another 10min, and filter. Fill each bottle with 100mL, sterilize at 105℃ for 30min, and you are done.

[0052] Example 4

[0053] First, take 1 part of dried tangerine peel, add 5 times the amount of water, extract volatile oil by steam distillation, mix the residue with 3 parts of polygonatum, 3 parts of ophiopogon, and 3 parts of poria, add 10 times the amount of water to extract twice, each time for 1.5 hours, filter, combine the filtrate, and concentrate. Then add 7 parts of donkey-hide gelatin and 3 parts of tortoise shell glue, melt, mix well, centrifuge at 4000r / min for 30 minutes, and add honey at a weight ratio of 1:1. Finally, add volatile oil from dried tangerine peel, stir well, fill, and sterilize to obtain the nourishing yin paste.

[0054] The following comparative examples 1-3 are individual prescriptions screened in the early stage of the experiment.

[0055] Comparative Example 1

[0056] The difference between this comparative example and Example 1 is that Polygonatum sibiricum is not contained.

[0057] First, take 11 parts of dried tangerine peel, add 5 times the amount of water, and extract volatile oil by steam distillation. Mix the residue with 7 parts of Ophiopogon japonicus and 7 parts of Poria cocos, add 10 times the amount of water and extract twice, each time for 1.5 hours, filter, combine the filtrate, and concentrate. Then add 5 parts of donkey-hide gelatin and 7 parts of tortoise shell glue, melt, mix well, centrifuge at 4000r / min for 30 minutes, and add honey at a weight ratio of 1:1. Finally, add the volatile oil of dried tangerine peel, stir well, fill and sterilize to obtain the nourishing yin paste.

[0058] Comparative Example 2

[0059] The difference between this comparative example and Example 1 is that it does not contain dried tangerine peel.

[0060] Take 11 parts of polygonatum, 7 parts of ophiopogon, and 7 parts of poria, add 10 times the amount of water to extract twice, each time for 1.5 hours, filter, combine the filtrate, and concentrate. Then add 5 parts of donkey-hide gelatin and 7 parts of tortoise shell glue, melt, mix, centrifuge at 4000r / min for 30min, add honey at a weight ratio of 1:1, stir well, fill, and sterilize to obtain the nourishing yin paste.

[0061] Comparative Example 3

[0062] The difference between this comparative example and Example 1 is that the preparation method is different.

[0063] Take 7 parts of polygonatum, 7 parts of ophiopogon, 4 parts of dried orange peel, 7 parts of poria, add 10 times the amount of water to extract twice, 2 hours each time, filter, combine the filtrate, and concentrate. Take 5 parts of donkey-hide gelatin and 7 parts of tortoise shell glue, add 4 parts of yellow wine, and melt in a 90℃ water bath. After mixing the above raw materials, add about 50g of honey at a weight ratio of 1:1.5. Add 1 part of ginger juice, 1 part of lemon juice, 1 part of jujube juice, etc. and heat in a water bath for 1 hour. Stir well, fill and sterilize to obtain the nourishing yin paste.

[0064] Experiment 1

[0065] The sensory requirements shall comply with the requirements of Table 1.

[0066]

[0067] The physical and chemical indicators meet the requirements of Table 2.

[0068]

[0069] The microbial indicators meet the requirements of Table 3.

[0070]

[0071] Experiment 2: Yin-nourishing and blood-tonifying efficacy experiment

[0072] 2.1 Preparation of Yin-blood Deficiency Animal Model

[0073] 90 200±20g SD female rats, 80 rats were randomly selected for modeling: 20 mg / Kg of acetophenhydramine saline solution was subcutaneously injected on the first day of the experiment, and all rats were allowed to eat freely. On the fourth day, 10 mg / Kg of acetophenhydramine saline solution was subcutaneously injected again, and then 2 hours after the injection, 20 mg / Kg of cyclophosphamide saline solution was intraperitoneally injected daily on the 4th, 5th, 6th and 7th days, and the model was successfully established.

[0074] The remaining 10 rats were used as the normal group and injected with an equal amount of saline solution according to the above method.

[0075] 2.2 Animal grouping

[0076] Ten rats were used as a normal group, and 80 modeling rats were randomly divided into 8 groups, namely, a model group, Example 1-4 groups, and Comparative Example 1-3 groups.

[0077] 2.3 Administration

[0078] Drug administration began on the second day after successful model establishment.

[0079] The rats in Example 1-4 and Comparative Example 1-3 were given the Chinese medicine composition prepared in the corresponding group at 3 g of raw medicine / kg.

[0080] The normal group and the model group were gavaged with an equal amount of distilled water once a day for 1 week.

[0081] 2.4 Index detection

[0082] One hour after the last administration, blood was collected from the eye sockets of each rat, and the values ​​of white blood cells (WBC), red blood cells (RBC), hemoglobin (HGB), and hematocrit (HCT) in peripheral blood were measured by an automatic blood analyzer. GraphPad Prism statistical software was used for analysis.

[0083] 2.5 The experimental results are shown in Table 4.

[0084]

[0085] Experiment 3 Anti-fatigue effect of the composition of the present invention on mice with kidney yin deficiency

[0086] 3.1 Modeling method: 80 20±2g IRC female mice were divided into groups, with 10 mice in each group. All mice were injected intramuscularly with 25mg / kg hydrocortisone once a day for 1 week to prepare the mouse model of kidney yang and kidney yin deficiency. The blood creatinine of the mice was higher than the normal value, the immunoglobulin IgM and IgG decreased significantly, the activity of the mice decreased, and the weight was reduced, and the model was successfully established.

[0087] 3.2 Dosage method: Start medication on the second day after successful modeling.

[0088] The mice in Example 1-4 and Comparative Example 1-3 groups were given the Chinese medicine composition prepared in the corresponding group, 4 g of raw medicine / kg, and the model group was given an equal amount of distilled water, once a day for 3 consecutive weeks.

[0089] 3.3 Experimental method: One hour after the last administration, the mice were swam with a weight (a lead sheet weighing 5% of their body weight was fixed to the base of their tail) in a 60cm×40cm×50cm water tank at 30±2℃ and 30cm deep. A stopwatch was used to record the number of times the mice sank within 20 minutes (during the test, some mice in each group sank to the bottom of the water in less than 20 minutes, and their tests were not included in the statistics), as well as the time from entering the water to exhaustion (not floating up within 5 seconds after entering the water).

[0090] 3.4 Experimental Results

[0091]

[0092] Compared with the embodiment formula, comparative example 1 does not add polygonatum, comparative example 2 does not add tangerine peel, and comparative example 3 does not extract volatile oil from tangerine peel compared with the embodiment formula. It can be seen from the efficacy evaluation experimental results that the prescription does not contain polygonatum, tangerine peel, or tangerine peel volatile oil, and each efficacy is significantly lower than that of the embodiment. It can be seen that the combination of the components in the present invention can enhance the effects of nourishing yin and blood and relieving physical fatigue. The volatile oil in tangerine peel plays a key and effective role in the formula, and the extraction of volatile oil in the process is indispensable.

[0093] The above detailed description is a specific description of one feasible embodiment of the present invention. The embodiment is not intended to limit the patent scope of the present invention. Any equivalent implementation or modification that does not deviate from the present invention should be included in the scope of the technical solution of the present invention.

Claims

1. A Yin nourishing composition, characterized in that: The raw materials of the Yin-nourishing composition are 1-7 parts of donkey-hide gelatin, 3-7 parts of tortoise shell glue, 3-7 parts of polygonatum, 3-7 parts of ophiopogon, 1-4 parts of dried tangerine peel, and 3-7 parts of tuckahoe; The preparation method of the composition comprises the following steps: (1) First, add 8-12 times the amount of water to the dried tangerine peel and boil it to extract the residue and volatile oil; (2) extracting the medicinal residue, polygonatum sibiricum, ophiopogon japonicus and poria cocos, filtering and obtaining a filtrate; (3) Then mix the filtrate, donkey hide gelatin and tortoise shell glue, and then add volatile oil to obtain the product; The extraction is performed by adding 8-12 times the amount of water for 1-3 times, and the time for each extraction is 1-3 hours; The mixing is to add donkey-hide gelatin and tortoise shell glue to the extract and melt it, or to melt the donkey-hide gelatin and tortoise shell glue first and then mix them with the extract.

2. A method for preparing the Yin nourishing composition according to claim 1, characterized in that: The steps include: (1) First, add 8-12 times the amount of water to the dried tangerine peel and boil it to extract the residue and volatile oil; (2) extracting the medicinal residue, polygonatum sibiricum, ophiopogon japonicus and poria cocos, filtering and obtaining a filtrate; (3) Then mix the filtrate, donkey hide gelatin and tortoise shell glue, and then add volatile oil to obtain the product; The extraction is performed by adding 8-12 times the amount of water for 1-3 times, and the time for each extraction is 1-3 hours; The mixing is to add donkey-hide gelatin and tortoise shell glue to the extract and melt it, or to melt the donkey-hide gelatin and tortoise shell glue first and then mix them with the extract.

3. The preparation method according to claim 2, characterized in that: The melting temperature is 80-90°C; And / or, the melting is further performed by adding yellow wine or water; And / or, after the mixing, the mixture is centrifuged at 3000-5000 r / min for 20-50 min and filtered to obtain the product.

4. A pharmaceutical preparation, characterized in that The invention comprises the Yin nourishing composition according to claim 1 and pharmaceutically acceptable excipients, wherein the preparation is an oral preparation.

5. The pharmaceutical preparation according to claim 4, characterized in that The dosage form of the preparation is a nourishing yin paste, and the auxiliary material is one or more of honey, ginger juice, lemon juice, jujube juice, and rice wine; Or, the dosage form of the preparation is a solution, and the auxiliary material is jujube juice; Alternatively, the dosage form of the preparation is granules, and the auxiliary material is powdered sugar, maltodextrin or dextrin.

6. Use of the Yin-nourishing composition according to claim 1 or the Yin-nourishing composition prepared by the preparation method according to any one of claims 2 to 3 in preparing a drug for preventing and treating Yin deficiency.

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