A continuous flow microchannel reactor with monitoring sensor

Abstract

The invention discloses a continuous flow microchannel reactor with a monitoring sensor, which belongs to the field of pharmaceutical equipment. A pressurized area can be set on the channel of the continuous flow microchannel reactor, and a micro-diaphragm pump is used to intermittently apply pressure in the pressurized area, so as to pressurize the fluid in the channel of the continuous flow microchannel reactor, thereby improving the fluid flow speed in the channel of the continuous flow microchannel reactor, thereby improving the fluid flux in the channel of the continuous flow microchannel reactor, ensuring that the pressure intermittently applied by the micro-diaphragm pump in the pressurized area achieves unidirectional acceleration, and increasing the production efficiency of drug preparation. By introducing an intelligent sensor, real-time processing of detection data and feedback are achieved, and while effectively monitoring the product output speed of the reactor, effective real-time control of the product output speed of the reactor can be achieved according to the real-time monitoring data.

Description

Technical Field

[0001] The invention relates to the field of pharmaceutical equipment, and more particularly to a continuous flow microchannel reactor with a monitoring sensor. Background Art

[0002] After searching, it is found that the continuous flow microchannel reactor is a practical application of microchemical technology. By carrying out reactions through micron-scale channel reactors, it can promote process intensification and miniaturization of chemical systems, improve resource utilization, save energy and reduce consumption, and fundamentally solve technical problems such as incomplete reactions and explosiveness in traditional processes.

[0003] The applicant has found that although the commonly used continuous flow microchannel reactor has a fast reaction speed, since the reaction occurs in a micron-sized channel reactor, the output rate of the final product is limited by the flux of the continuous flow microchannel reactor. Under the premise that the internal channel cross-sectional area of ​​the channel reactor remains unchanged, the flow rate of the continuous flow microchannel reactor determines the flux of the continuous flow microchannel reactor.

[0004] The applicant believes that the circulation velocity of the continuous flow microchannel reactor is determined by the dispensing pump. In order to protect the channel of the continuous flow microchannel reactor from being damaged by high pressure, the initial pressure of the dispensing pump is low. The channel length of the continuous flow microchannel reactor is relatively long. In order to effectively utilize the space, the channel of the continuous flow microchannel reactor is usually more tortuous, resulting in a lower channel end velocity of the continuous flow microchannel reactor, which makes the flux of the continuous flow microchannel reactor less, affecting the production efficiency of drug preparation. Summary of the invention

[0005] 1. Technical issues to be solved

[0006] In view of the problems existing in the prior art, the purpose of the present invention is to provide a continuous flow microchannel reactor with a monitoring sensor, which can realize setting a pressurized area on the channel of the continuous flow microchannel reactor, and using a micro diaphragm pump to intermittently apply pressure in the pressurized area, so as to pressurize the fluid in the channel of the continuous flow microchannel reactor, thereby improving the fluid circulation speed in the channel of the continuous flow microchannel reactor, and has a certain creativity, thereby improving the fluid flux in the channel of the continuous flow microchannel reactor, increasing the production efficiency of drug preparation, and has a certain practicality. Tesla valves are provided between adjacent pressurized areas, and between the initial pressurized area and the micro mixer, which effectively prevent the fluid in the channel of the continuous flow microchannel reactor from being pressurized and reflux, and ensure that the pressure intermittently applied by the micro diaphragm pump in the pressurized area achieves unidirectional acceleration, and has a certain novelty.

[0007] 2. Technical solution

[0008] To solve the above problems, the present invention adopts the following technical solutions.

[0009] A continuous flow microchannel reactor with a monitoring sensor comprises a reactor, a feeding pipe is arranged at one end of the reactor, a discharging pipe is arranged at the end of the reactor away from the feeding pipe, a display screen is also installed on the reactor, a dispensing pump is arranged at the end of the feeding pipe, and a microchannel diverter is connected to the end of the dispensing pump away from the feeding pipe, a diversion manifold is distributed at the end of the microchannel diverter away from the dispensing pump, and a reaction plate is connected to the end of the diversion manifold away from the microchannel diverter;

[0010] A reaction plate input end is cut on the reaction plate, a flow dividing manifold is connected to the reaction plate input end, a micro mixer is arranged at one end of the reaction plate input end away from the flow dividing manifold, a reaction channel is connected to the micro mixer, a Tesla valve and a pressurized diaphragm are spaced apart on the reaction channel, a reaction plate output end is arranged at the end of the reaction channel, a reaction plate installer is installed in the reactor, a mounting groove is cut on the reaction plate installer, the reaction plate is fixedly installed in the mounting groove, a diaphragm pump limiter is also installed in the reactor, a limit plate is connected to the diaphragm pump limiter, a micro diaphragm pump is installed in an adjacent limit plate, the micro diaphragm pump comprises a pump body and an output shaft, and the output shaft is a reciprocating shaft, both ends of the output shaft are fitted with the pressurized diaphragm of the reaction plate, a pressurized area can be arranged on the channel of the continuous flow microchannel reactor, and pressure is intermittently applied in the pressurized area by the micro diaphragm pump, so as to pressurize the fluid in the channel of the continuous flow microchannel reactor, thereby improving the continuous flow microchannel. The fluid circulation speed in the reactor channel has a certain creativity, so as to improve the fluid flux in the continuous flow microchannel reactor channel, increase the production efficiency of drug preparation, and have a certain practicality. Tesla valves are provided between adjacent pressurized areas, as well as between the initial pressurized area and the micro-mixer, which effectively prevent the fluid in the continuous flow microchannel reactor channel from being pressurized and reflux, and ensure that the pressure intermittently applied by the micro-diaphragm pump in the pressurized area achieves unidirectional acceleration. It has a certain novelty. The end of the reaction plate output end away from the reaction plate is connected to a combiner, and the end of the combiner away from the reaction plate output end is connected to the discharge pipe. A flow rate monitoring sensor is installed at the connection between the combiner and the discharge pipe, and the flow rate monitoring sensor uses an intelligent sensor, which can realize real-time processing and feedback of the detection data. While effectively monitoring the product output speed of the reactor, it can also realize effective real-time control of the product output speed of the reactor according to the real-time monitoring data.

[0011] Furthermore, a sensor is installed in the reactor, and the sensor is associated with a display screen. The working state of the sensor can be monitored in real time through the display screen, and the reaction state of the fluid in the reaction plate can be detected by the sensor.

[0012] Furthermore, the overall reaction channel is a serpentine tube structure, which can effectively utilize the spatial area of ​​the reaction plate to extend the effective length of the reaction channel.

[0013] Furthermore, the low-resistance flow direction of the Tesla valve conforms to the flow direction of the fluid in the reaction channel, which can ensure the one-way flow of the fluid in the reaction channel and effectively prevent the fluid in the reaction channel from flowing back from the pressurized diaphragm when the micro-diaphragm pump is operating.

[0014] Furthermore, the inner side of the pressurized diaphragm is coated with a corrosion-resistant coating, which effectively prevents the pressurized diaphragm from being corroded by the fluid in the reaction channel.

[0015] Furthermore, the pressurized diaphragm is externally connected to a mounting frame, and the pressurized diaphragm is snap-connected to the reaction plate through the mounting frame, which is conducive to timely replacement of the pressurized diaphragm when it is damaged, thereby ensuring continuous use of the reaction plate.

[0016] Furthermore, the diaphragm pump limiter is located between adjacent installation grooves, ensuring that reaction plates are installed on both sides of the micro diaphragm pump, which is beneficial for alternately pressurizing the pressurized diaphragms of the reaction plates on both sides of the micro diaphragm pump when the output shaft reciprocates, thereby improving the utilization efficiency of the micro diaphragm pump.

[0017] Furthermore, a limit groove is cut on the side wall of the pump body, and the limit plate of the diaphragm pump limiter is clamped in the limit groove, so as to facilitate the fixed installation of the micro diaphragm pump.

[0018] Furthermore, a pressure plate is attached to the pressurized diaphragm of the reaction plate, and the pressure plate is connected to a transmission rod. The end of the transmission rod away from the pressure plate is connected to a reciprocating pump. The output end of the reciprocating pump is linked to the transmission rod, so that the output end of the reciprocating pump drives multiple transmission rods to drive the pressure plate, which is conducive to streamlining the power source.

[0019] 3. Beneficial effects

[0020] Compared with the prior art, the advantages of the present invention are:

[0021] (1) This scheme can realize setting a pressurized area on the channel of the continuous flow microchannel reactor, and using a micro diaphragm pump to intermittently apply pressure to the pressurized area, thereby pressurizing the fluid in the continuous flow microchannel reactor channel, thereby increasing the fluid flow rate in the continuous flow microchannel reactor channel, which has a certain degree of creativity, thereby improving the fluid flux in the continuous flow microchannel reactor channel and increasing the production efficiency of drug preparation, and has a certain degree of practicality. Tesla valves are provided between adjacent pressurized areas and between the initial pressurized area and the micro mixer, which effectively prevent the fluid in the continuous flow microchannel reactor channel from being pressurized and reflux, and ensure that the pressure intermittently applied by the micro diaphragm pump in the pressurized area achieves unidirectional acceleration, which has a certain degree of novelty.

[0022] (2) A sensor is also installed in the reactor. The sensor is associated with a display screen. The display screen can monitor the working status of the sensor in real time and detect the reaction status of the fluid in the reaction plate through the sensor.

[0023] (3) The overall reaction channel is a serpentine tube structure, which can effectively utilize the spatial area of ​​the reaction plate to extend the effective length of the reaction channel.

[0024] (4) The low-resistance flow direction of the Tesla valve is consistent with the flow direction of the fluid in the reaction channel, which can ensure the one-way flow of the fluid in the reaction channel and effectively prevent the fluid in the reaction channel from flowing back from the pressurized diaphragm when the micro-diaphragm pump is operating.

[0025] (5) The inner side of the pressurized diaphragm is coated with a corrosion-resistant coating, which effectively prevents the pressurized diaphragm from being corroded by the fluid in the reaction channel.

[0026] (6) The pressurized diaphragm is externally connected to a mounting frame, and the pressurized diaphragm is snap-fitted onto the reaction plate through the mounting frame, which is conducive to timely replacement of the pressurized diaphragm when it is damaged, thereby ensuring the continuous use of the reaction plate.

[0027] (7) The end of the reaction plate output away from the reaction plate is connected to a combiner, and the end of the combiner away from the reaction plate output is connected to a discharge pipe. A flow rate monitoring sensor is installed at the connection between the combiner and the discharge pipe, which can effectively monitor the product output rate of the reactor.

[0028] (8) The diaphragm pump limiter is located between adjacent mounting grooves, ensuring that reaction plates are installed on both sides of the micro diaphragm pump. This is beneficial for alternately applying pressure to the pressurized diaphragms of the reaction plates on both sides of the micro diaphragm pump when the output shaft reciprocates, thereby improving the utilization efficiency of the micro diaphragm pump.

[0029] (9) A limit groove is cut on the side wall of the pump body, and the limit plate of the diaphragm pump limiter is clamped in the limit groove, which is convenient for fixing and installing the micro diaphragm pump.

[0030] (10) A pressure plate is attached to the pressurized diaphragm of the reaction plate, and the pressure plate is connected to a transmission rod. The end of the transmission rod away from the pressure plate is connected to a reciprocating pump. The output end of the reciprocating pump is linked to the transmission rod, so that the output end of the reciprocating pump drives multiple transmission rods to drive the pressure plate, which is conducive to streamlining the power source. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 It is a structural schematic diagram of the present invention;

[0032] Figure 2 It is a schematic diagram of the internal reaction plate arrangement structure of the present invention;

[0033] Figure 3 It is a structural schematic diagram of the reaction plate of the present invention in an installed state;

[0034] Figure 4 It is a schematic diagram of the position relationship structure of the diaphragm pump limiter of the present invention;

[0035] Figure 5 It is a schematic diagram of the front structure of the reaction plate of the present invention;

[0036] Figure 6 It is a schematic diagram of the back structure of the reaction plate of the present invention;

[0037] Figure 7 It is a schematic diagram of the internal structure of the reaction plate of the present invention;

[0038] Figure 8 It is a structural schematic diagram of a reaction plate installation device of the present invention;

[0039] Fig. 9 It is a schematic diagram of the assembly structure of the micro diaphragm pump of the present invention;

[0040] Fig.10 It is a schematic diagram of the structure of the micro diaphragm pump of the present invention.

[0041] Description of the numbers in the figure:

[0042] 1 reactor, 2 feeding tube, 3 discharging tube, 4 display screen, 5 reaction plate, 501 reaction plate input end, 502 reaction plate output end, 503 pressurized diaphragm, 504 micro mixer, 505 reaction channel, 506 Tesla valve, 6 reaction plate installer, 601 installation slot, 7 diaphragm pump stopper, 701 limit plate, 8 micro diaphragm pump, 801 pump body, 802 limit slot, 803 output shaft. DETAILED DESCRIPTION

[0043] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention; it is obvious that the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments, and all other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making creative work are within the scope of protection of the present invention.

[0044] In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "top / bottom" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific position, be constructed and operated in a specific position, and therefore cannot be understood as limiting the present invention. In addition, the terms "first" and "second" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance.

[0045] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "provided with", "mounted / connected", "connected", etc. should be understood in a broad sense. For example, "connected" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances. Example 1

[0046] See also Figure 1-7 A continuous flow microchannel reactor with a monitoring sensor comprises a reactor 1, a feeding pipe 2 is arranged at one end of the reactor 1, a discharge pipe 3 is arranged at the end of the reactor 1 away from the feeding pipe 2, a display screen 4 is also installed on the reactor 1, a sensor is also installed in the reactor 1, the sensor is associated with the display screen 4, the working state of the sensor can be monitored in real time through the display screen 4, the reaction state of the fluid in the reaction plate 5 can be detected by the sensor, a dispensing pump is arranged at the end of the feeding pipe 2, and the end of the dispensing pump away from the feeding pipe 2 is connected to a microchannel flow divider A microchannel diverter is provided with a diversion manifold at one end of the microchannel diverter away from the dispensing pump, a reaction plate 5 is connected to one end of the diversion manifold away from the microchannel diverter, a reaction plate input end 501 is cut on the reaction plate 5, the diversion manifold is connected to the reaction plate input end 501, a micro mixer 504 is provided at one end of the reaction plate input end 501 away from the diversion manifold, a reaction channel 505 is connected to the micro mixer 504, and the reaction channel 505 is a serpentine tube structure as a whole, which can effectively utilize the spatial area of ​​the reaction plate 5, thereby extending the effective length of the reaction channel 505. The length of the reaction channel 505 is that Tesla valves 506 and pressurized diaphragms 503 are spaced apart on the reaction channel 505. The pressurized diaphragm 503 is externally connected to a mounting frame. The pressurized diaphragm 503 is clamped on the reaction plate 5 through the mounting frame, which is conducive to timely replacement of the pressurized diaphragm 503 when the pressurized diaphragm 503 is damaged, thereby ensuring the continuous use of the reaction plate 5. The inner side of the pressurized diaphragm 503 is coated with a corrosion-resistant coating, which effectively prevents the pressurized diaphragm 503 from being corroded by the fluid in the reaction channel 505. A reaction plate output end 502 is provided at the end of the reaction channel 505. The end of the reaction plate output end 502 away from the reaction plate 5 is connected to a combiner, and the end of the combiner away from the reaction plate output end 502 is connected to the discharge pipe 3. A flow rate monitoring sensor is installed at the connection between the combiner and the discharge pipe 3, which can effectively monitor the product output speed of the reactor 1. The flow rate monitoring sensor is an intelligent sensor, which can realize real-time processing and feedback of the detection data. While effectively monitoring the product output speed of the reactor, it can also realize effective real-time control of the product output speed of the reactor according to the real-time monitoring data.

[0047] See also Figure 7-10 A reaction plate installer 6 is installed in the reactor 1, and an installation groove 601 is cut on the reaction plate installer 6. The reaction plate 5 is fixedly installed in the installation groove 601. A diaphragm pump limiter 7 is also installed in the reactor 1. The diaphragm pump limiter 7 is located between adjacent installation grooves 601, ensuring that reaction plates 5 are installed on both sides of the micro diaphragm pump 8, which is beneficial to alternately pressurizing the pressurized diaphragms 503 of the reaction plates 5 on both sides of the micro diaphragm pump 8 when the output shaft 803 reciprocates, thereby improving the utilization efficiency of the micro diaphragm pump 8. A limiting plate 701 is connected to the diaphragm pump limiter 7, and a micro diaphragm pump 8 is installed in the adjacent limiting plate 701. The low resistance flow direction of the Tesla valve 506 conforms to the flow direction of the fluid in the reaction channel 505, and can ensure the unidirectional flow of the fluid in the reaction channel 505. The micro-diaphragm pump 8 can effectively prevent the fluid in the reaction channel 505 from flowing back from the pressurized diaphragm 503 when the micro-diaphragm pump 8 is operating. The micro-diaphragm pump 8 includes a pump body 801 and an output shaft 803, and a limiting groove 802 is drilled on the side wall of the pump body 801. The limiting plate 701 of the diaphragm pump limiter 7 is clamped in the limiting groove 802, which is convenient for fixing and installing the micro-diaphragm pump 8. The output shaft 803 is a reciprocating shaft, and both ends of the output shaft 803 are in contact with the pressurized diaphragm 503 of the reaction plate 5. Another scheme for the power source of the pressurized diaphragm 503 is that a pressure plate is in contact with the pressurized diaphragm 503 of the reaction plate 5, and the pressure plate is connected to a transmission rod. The end of the transmission rod away from the pressure plate is connected to a reciprocating pump, and the output end of the reciprocating pump is linked with the transmission rod, so that the output end of the reciprocating pump drives multiple transmission rods to drive the pressure plate, which is conducive to streamlining the power source.

[0048] When in use, the pharmaceutical raw materials are transported from the feeding tube 2 to the reaction plate input end 501 of the reaction plate 5, and a variety of pharmaceutical raw materials enter the micro mixer 504 through different reaction plate input ends 501 to be fully mixed. The mixed pharmaceutical raw materials enter the reaction channel 505 for pharmaceutical reaction, and the fluid in the reaction enters the pressurizing diaphragm 503 through the Tesla valve 506. The output shaft 803 of the micro diaphragm pump 8 applies pressure to the pressurizing diaphragm 503 to increase the pressure on the fluid in the reaction channel 505, and the output shaft 803 of the micro diaphragm pump 8 applies pressure to the pressurizing diaphragm 503 to increase the pressure on the fluid in the reaction channel 505. When pressure is applied to the diaphragm 503, part of the refluxed fluid is blocked by the Tesla valve 506, thereby achieving unidirectional acceleration of the fluid in the reaction channel 505 by the micro-diaphragm pump 8, thereby increasing the flow rate of the fluid in the reaction channel 505, and ultimately increasing the production efficiency of drug preparation. In order to prevent the fluid flow time in the reaction channel 505 from being too short, resulting in insufficient reaction, the length of the reaction channel 505 is appropriately extended. Without changing the flux of the reaction channel 505, the flow time of the unit volume of fluid in the reaction channel 505 is extended. It is possible to set a pressurized area on the channel of the continuous flow microchannel reactor, and use a micro diaphragm pump to intermittently apply pressure to the pressurized area, so as to pressurize the fluid in the channel of the continuous flow microchannel reactor, thereby increasing the fluid flow rate in the channel of the continuous flow microchannel reactor. It has a certain creativity, so as to improve the fluid flux in the channel of the continuous flow microchannel reactor and increase the production efficiency of drug preparation. It has a certain practicality. Tesla valves are provided between adjacent pressurized areas and between the initial pressurized area and the micro mixer, which effectively prevent the fluid in the channel of the continuous flow microchannel reactor from being pressurized and backflow, and ensure that the pressure intermittently applied by the micro diaphragm pump in the pressurized area achieves unidirectional acceleration, which has a certain novelty.

[0049] The above is only a preferred specific implementation of the present invention; however, the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical solution and its improved conception within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A continuous flow microchannel reactor with a monitoring sensor, comprising a reactor (1), wherein one end of the reactor (1) is provided with a feeding pipe (2), an end of the reactor (1) away from the feeding pipe (2) is provided with a discharge pipe (3), and a display screen (4) is also installed on the reactor (1), characterized in that: The end of the feeding tube (2) is provided with a dispensing pump, the end of the dispensing pump away from the feeding tube (2) is connected to a microchannel diverter, the end of the microchannel diverter away from the dispensing pump is provided with a diverter manifold, and the end of the diverter manifold away from the microchannel diverter is connected to a reaction plate (5); The reaction plate (5) is provided with a reaction plate input end (501), and a flow dividing manifold is connected to the reaction plate input end (501); a micro mixer (504) is provided at one end of the reaction plate input end (501) away from the flow dividing manifold; a reaction channel (505) is connected to the micro mixer (504); a Tesla valve (506) and a pressurizing diaphragm (503) are arranged at intervals on the reaction channel (505); a reaction plate output end (502) is provided at the end of the reaction channel (505); a flow combiner is connected at one end of the reaction plate output end (502) away from the reaction plate (5); and an end of the flow combiner away from the reaction plate output end (502) is in communication with a discharge pipe (3); and the flow combiner is connected to the discharge pipe (3). A flow rate monitoring sensor is installed at the connection, and the flow rate monitoring sensor is an intelligent sensor. A reaction plate mounter (6) is installed in the reactor (1), and a mounting groove (601) is cut on the reaction plate mounter (6), and the reaction plate (5) is fixedly installed in the mounting groove (601). A diaphragm pump stopper (7) is also installed in the reactor (1), and a limit plate (701) is connected to the diaphragm pump stopper (7), and a micro diaphragm pump (8) is installed in the limit plate (701), and the micro diaphragm pump (8) comprises a pump body (801) and an output shaft (803), and the output shaft (803) is a reciprocating shaft, and both ends of the output shaft (803) are in contact with the pressurized diaphragm (503) of the reaction plate (5); A pressure plate is attached to the pressurized diaphragm (503) of the reaction plate (5), and the pressure plate is an optional component. The pressure plate is connected to a transmission rod, and the end of the transmission rod away from the pressure plate is connected to a reciprocating pump, and the output end of the reciprocating pump is linked to the transmission rod.

2. A continuous flow microchannel reactor with a monitoring sensor according to claim 1, characterized in that: A sensor is also installed in the reactor (1), and the sensor is associated with the display screen (4).

3. A continuous flow microchannel reactor with a monitoring sensor according to claim 1, characterized in that: The reaction channel (505) is a serpentine tube structure as a whole.

4. A continuous flow microchannel reactor with a monitoring sensor according to claim 1, characterized in that: The low resistance flow direction of the Tesla valve (506) is consistent with the flow direction of the fluid in the reaction channel (505).

5. A continuous flow microchannel reactor with a monitoring sensor according to claim 1, characterized in that: The inner side surface of the pressurizing diaphragm (503) is coated with a corrosion-resistant coating.

6. A continuous flow microchannel reactor with a monitoring sensor according to claim 1, characterized in that: The pressurizing diaphragm (503) is externally connected to a mounting frame, and the pressurizing diaphragm (503) is clamped onto the reaction plate (5) through the mounting frame.

7. A continuous flow microchannel reactor with a monitoring sensor according to claim 1, characterized in that: The diaphragm pump stopper (7) is located between adjacent mounting grooves (601).

8. The continuous flow microchannel reactor with a monitoring sensor according to claim 1, characterized in that: A limiting groove (802) is cut on the side wall of the pump body (801), and the limiting plate (701) of the diaphragm pump limiter (7) is clamped in the limiting groove (802).

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