A semi-automatic liquid preparation process with jacket air isolation function

Abstract

The present invention provides a semi-automatic liquid preparation process with jacket air isolation function, which belongs to the field of pharmaceutical liquid preparation technology. It solves the problems of low liquid preparation efficiency, unstable and easy contamination of refrigerant system in existing liquid preparation process. The liquid preparation process includes the following steps: integrity detection; cleaning and disinfection; sterilization of jacket layer and injection of refrigerant; liquid preparation and mixing; refrigerant reflux; repeating the above steps; replacement of air isolation mechanism filter. It also includes CIP disinfection supply pipeline, CIP disinfection reflux pipeline, ethylene glycol supply pipeline, ethylene glycol reflux pipeline, pure pressure steam pipeline, clean compressed air pipeline, CIP / material pressure pipeline, pressurized hot exhaust pipeline, pressurized cold exhaust pipeline, liquid preparation tank, integrity detector, air isolation mechanism, isolation tank and buffer tank connected to filling machine. The layout of each pipeline of the present invention is reasonable, the input and output are stable and efficient, liquid preparation can be carried out efficiently, integrity detection can be carried out, the refrigerant system is stable and pure, and the filter is easy to replace.

Description

Technical Field

[0001] The invention belongs to the technical field of pharmaceutical liquid preparation, and relates to a semi-automatic liquid preparation process with a jacket air isolation function. Background Art

[0002] Pharmaceutical liquid preparation is a chemical production process, which generally uses a liquid preparation tank for mixing. The liquid preparation tank has a temperature control requirement, so the liquid preparation tank adopts a jacket design, and industrial steam or chilled water is supplied through the jacket to exchange heat with the cylinder inside the liquid preparation tank to achieve the heating and cooling requirements of the liquid preparation tank. When the heating and cooling functions of the liquid preparation tank jacket are switched, the chilled water filled in the jacket needs to be emptied. According to comprehensive considerations of environmental protection requirements and cost savings, the chilled water cannot be discharged directly to the outdoors when it is emptied. Most of the chilled water contains refrigerants such as ethylene glycol and propylene glycol, but is recycled into the circulation network of the refrigeration station.

[0003] Combined with the mainstream design of semi-automation of the current liquid preparation process, a compressed air purge process is added to the chilled water return pipe of the liquid preparation tank jacket, and all the chilled water in the liquid preparation tank jacket is blown back to the chilled water return pipe from top to bottom, thereby realizing the pipe network recovery of chilled water; at the same time, the layout of each pipeline of the existing liquid preparation process is unreasonable. How to ensure the stability and purity of the air-isolated refrigerant system, that is, to effectively block the compressed air from entering the chilled water return pipe to avoid air entry and filter the refrigerant, is an urgent problem to be solved.

[0004] Based on this, we propose a semi-automatic liquid preparation process with jacket air isolation function. Summary of the invention

[0005] The purpose of the present invention is to address the above-mentioned problems in the existing technology and propose a semi-automatic liquid preparation process with jacket air isolation function. The technical problem to be solved by the invention is: how to achieve a reasonable layout of pipelines, stable and efficient input and output, efficient liquid preparation, integrity testing, stable and pure refrigerant system, and easy replacement of filters.

[0006] The purpose of the present invention can be achieved by the following technical solutions:

[0007] A semi-automatic liquid preparation process with jacket air isolation function, comprising a CIP disinfection supply pipeline, a CIP disinfection return pipeline, an ethylene glycol supply pipeline, an ethylene glycol return pipeline, a pure pressure steam pipeline, a clean compressed air pipeline, a CIP / material pressure pipeline, a pressurized hot exhaust pipeline, a pressurized cold exhaust pipeline, a liquid preparation tank, an integrity detector, an air isolation mechanism, an isolation tank, and a buffer tank connected to a filling machine, wherein the CIP disinfection supply pipeline and the liquid preparation tank and a manual take-out tank connected to the liquid preparation tank are connected to the semi-automatic liquid preparation process. The sample valve is connected, the liquid preparation tank is connected to the CIP disinfection return pipeline and the pressurized heat exhaust pipeline, the manual sampling valve is connected to the pressurized heat exhaust pipeline, the ethylene glycol supply pipeline and the ethylene glycol return pipeline are both connected to the jacket layer of the liquid preparation tank, the ethylene glycol supply pipeline and the ethylene glycol return pipeline are connected, and the air isolation mechanism is connected to the ethylene glycol return pipeline, the air isolation mechanism is connected to the pressurized heat exhaust pipeline and the pressurized cold exhaust pipeline, the pure pressure steam pipeline and the clean compressed air pipeline are both connected to the jacket layer of the liquid preparation tank The liquid inlet end is connected, the liquid preparation tank and the buffer tank are connected through a pipeline, the CIP disinfection supply pipeline is also connected to the pipeline between the liquid preparation tank and the buffer tank, and the CIP disinfection supply pipeline connection is located at the discharge end of the liquid preparation tank, and the pipeline between the liquid preparation tank and the buffer tank is also provided with filter one and filter two, the integrity detector and the isolation tank are both connected in parallel with filter one, and the pipeline between the integrity detector and filter one is connected with filter three, the pure pressure steam pipeline is connected to the pipeline of the integrity detector and filter three, and the pure pressure steam pipeline is connected to the pressurized hot exhaust pipeline, the CIP disinfection reflux pipeline is connected between the isolation tank and the buffer tank, the pure pressure steam pipeline is connected to the ethylene glycol supply pipeline and the isolation tank, the isolation tank is connected to the pressurized cold exhaust pipeline, filter one, filter two, filter three, clean compressed air pipeline and liquid preparation tank are all connected to the pressurized cold exhaust pipeline, the CIP / material pressure pipeline is connected to the feed end of the liquid preparation tank, and the CIP disinfection reflux pipeline is connected to the pressurized hot exhaust pipeline.

[0008] The working principle of the present invention is as follows: filter one is steam sterilized through a pure pressure steam pipeline, and then an integrity detector performs an integrity detection on filter one to determine whether the filter element is damaged. If the detection result is qualified, it means that the filter element is not damaged; if the result fails, it means that the filter element is damaged and needs to be replaced; the clean compressed air pipeline discharges the water that wets the filter element to the isolation tank, and the sterile system is isolated from the sewage system through the principle of the isolation tank water seal; the liquid preparation tank is cleaned and disinfected through the CIP disinfection supply pipeline, and the CIP disinfection supply pipeline connection is located at the discharge end of the liquid preparation tank to clean and disinfect the subsequent connected pipelines, as well as the filter one and filter two connected by the subsequent pipelines and the buffer tank. Then, the CIP / material pressure pipeline is used for cleaning and disinfection, and then the cleaning and disinfection waste liquid is refluxed through the CIP disinfection reflux pipeline. At this time, the inside of the jacket layer of the liquid preparation tank is empty, and then the raw materials are injected into the liquid preparation tank through the CIP / material pressure pipeline, and at the same time, the pure pressure steam pipeline is used to steam sterilize the inside of the jacket layer Bacteria, and disinfect the air isolation mechanism. The sewage generated by the above steam sterilization is discharged through the pressurized hot exhaust pipeline or the pressurized cold exhaust pipeline, and then ethylene glycol is injected into the jacket layer through the ethylene glycol supply pipeline to control the temperature of the liquid preparation tank. The liquid preparation tank stirs and mixes the raw materials at the temperature control temperature to obtain a mixed material. The mixed material is filtered through filter one, and then filtered through filter two, enters the buffer tank for storage, and finally injected into the filling machine; then the clean compressed air pipeline injects air into the jacket layer of the liquid preparation tank, and after all the ethylene glycol in the jacket layer is filtered and separated through the air isolation mechanism, the ethylene glycol is refluxed and collected through the ethylene glycol reflux pipeline, and then steam is injected into the jacket layer of the empty liquid preparation tank through the pure pressure steam pipeline for cleaning, and the wastewater is injected into the waste box and discharged through the pressurized cold exhaust pipeline and the pressurized hot exhaust pipeline, the ethylene glycol waste liquid is discharged through the pressurized cold exhaust pipeline, and the steam wastewater is discharged through the pressurized hot exhaust pipeline; and the liquid preparation tank is repeatedly cleaned, disinfected, sterilized and filled.

[0009] The CIP disinfection supply pipeline, CIP disinfection return pipeline, ethylene glycol supply pipeline, ethylene glycol return pipeline, pure pressure steam pipeline, clean compressed air pipeline, pressurized hot exhaust pipeline, and pressurized cold exhaust pipeline are all inclined pipelines with the feed end higher than the discharge end.

[0010] With the above structure, the inclined pipeline facilitates the internal material to flow through its own gravity, thereby reducing energy consumption.

[0011] The ethylene glycol supply pipeline, the ethylene glycol reflux pipeline, and the pipeline between the liquid distribution tank and the buffer tank are all cold-insulated pipelines, and the pure pressure steam pipeline is a heat-insulated pipeline.

[0012] With the above structure, the cold-insulating pipeline is used to keep the materials inside it cold, and the hot-insulating pipeline is used to keep the materials inside it hot to ensure the temperature requirements.

[0013] A cleaning ball is provided below the feed end of the liquid distribution tank connected to the CIP disinfection return pipeline, a heating filter is provided at one of the feed ends of the isolation tank, the clean compressed air pipeline and the pressurized hot exhaust pipeline are connected, and a heating filter is connected in parallel on the pipeline connecting the clean compressed air pipeline and the pressurized hot exhaust pipeline.

[0014] With the above structure, the cleaning ball is used to discharge the disinfecting cleaning liquid, clean the liquid preparation tank, and the heating filter is used for heat preservation filtration.

[0015] The pipeline between the liquid distribution tank and the buffer tank is also a cold-keeping pipeline. The exhaust ends of filter 1 and filter 2 are connected with pipeline test mirrors, and the pipeline test mirrors are connected with the pressurized hot exhaust pipeline.

[0016] With the above structure, filter one and filter two are used for double filtering of product materials. When one of the filters is damaged, filtering can still be performed to ensure the sterility of the product. The exhaust ends of filter one and filter two are used for exhaust. The air is injected into the pressurized hot exhaust pipeline. The pipeline test mirror is used to observe whether the liquid inside filter one and filter two is full, that is, whether all the air is exhausted.

[0017] The filter 2 and the buffer tank are both located at the filling machine, and the cold-keeping pipeline on the front side of the filter 2 and the cold-keeping pipeline between the filter 2 and the buffer tank are both connected to the pressurized heat exhaust pipeline.

[0018] With the above structure, the cold-keeping pipelines are all connected to the pressurized hot discharge pipelines for discharging waste materials.

[0019] A magnetic stirrer is provided inside the liquid preparation tank, an integrated sight glass and a lighting lamp are provided on the liquid preparation tank, a feed port is provided on the liquid preparation tank, the pressure of the compressed air pipeline, the CIP disinfection supply pipeline, the pure pressure steam pipeline and the clean compressed air pipeline is 7 bar, the pressure of the CIP / material pressure pipeline is 4 bar, and the ethylene glycol liquid temperature of the ethylene glycol supply pipeline is 2-7°C.

[0020] With the above structure, raw materials are injected into the liquid preparation tank through the feed port, and the magnetic stirrer stirs and mixes the raw materials.

[0021] The air isolation mechanism includes a lifting component, a waste box and a liquid cartridge component which are arranged in sequence; a stirring component and a filter separation component are fixed on the lifting component; the filter separation component is detachably engaged in the interior of the liquid cartridge component; both the filter separation component and the liquid cartridge component are connected to the jacket layer of the liquid dispensing tank; the liquid cartridge component is connected to the ethylene glycol reflux pipeline; both the filter separation component and the liquid cartridge component are connected to the waste box; and the waste box is connected to the pressurized cold discharge pipeline.

[0022] With the above structure, the clean compressed air pipeline injects compressed air into the jacket layer of the liquid dispensing tank filled with ethylene glycol coolant, and after the ethylene glycol coolant is pressed into the interior of the filter separation component, the stirring component stirs, and the filtered ethylene glycol coolant enters the interior of the liquid cylinder component, and then flows back to the ethylene glycol reflux pipeline for repeated recycling. However, when the liquid level of the ethylene glycol coolant in the liquid cylinder component reaches a certain position, impurities are placed in the filter separation component. Then, steam is injected into the jacket layer of the empty liquid dispensing tank through the pure pressure steam pipeline to clean it, and then passes through the interior of the filter separation component to clean it. The steam and the ethylene glycol coolant retained in the filter separation component form a mixed liquid, and the mixed liquid is The ethylene glycol coolant in the combined liquid is refluxed to the ethylene glycol reflux pipeline through the filter separation component and the liquid cylinder component in turn, and is repeatedly recycled until the ethylene glycol coolant inside the liquid cylinder component is completely refluxed, and then steam is injected into the liquid cylinder component for cleaning, and the waste water from cleaning the filter separation component and the liquid cylinder component is injected into the waste material box, and the ethylene glycol waste liquid is discharged through the pressurized cold exhaust pipeline, and the steam waste water is discharged through the pressurized hot exhaust pipeline; when it is necessary to replace the parts of the filter separation component, the lifting component drives the stirring component and the filter separation component to rise, and after replacement, the lifting component drives the stirring component and the filter separation component to descend, and the filter separation component and the liquid cylinder component are sealed and engaged to continue the filtering process.

[0023] The lifting component includes a fixed frame and a lifting seat, a lifting hydraulic push rod is fixed on the upper end of the fixed frame, a plurality of rollers are fixed on the lifting seat, the rollers are rotatably arranged on the fixed frame, the telescopic end of the lifting hydraulic push rod is fixedly connected to the lifting seat, and a storage rack is fixed on the side of the lifting seat;

[0024] The stirring component comprises a stirring motor and a mounting frame, wherein the mounting frame is fixed to the upper end of the storage rack, the stirring motor is fixed to the upper end of the mounting frame, the output shaft of the stirring motor passes through the mounting frame and the stirring shaft is fixed to the output shaft of the stirring motor.

[0025] With the above structure, the telescopic end of the lifting hydraulic push rod drives the lifting seat to move up and down, a number of rollers roll on the fixed stand, and the lifting seat drives the storage rack to move up and down;

[0026] The lifting of the storage rack drives the stirring component to lift, so that the output shaft of the stirring motor drives the stirring shaft to rotate, stirring the ethylene glycol coolant inside.

[0027] The liquid-setting cylinder component comprises a bracket, on which a liquid-setting cylinder body is fixed, an upper sealing socket is provided at the upper end of the liquid-setting cylinder body, a connector and a mounting joint are provided at the side of the liquid-setting cylinder body, a cleaning ball 2 is provided inside the connector, a liquid level gauge is connected to the mounting joint, an internal sealing socket is provided at the middle of the lower end of the liquid-setting cylinder body, a avoidance through hole is provided inside the internal sealing socket, and a liquid outlet pipe connected thereto is provided at the lower end of the liquid-setting cylinder body;

[0028] The filtering and separation component comprises a mounting top cylinder, a filter membrane cylinder and a lower connecting piece, the upper end of the mounting top cylinder is fixed with a mounting seat, the mounting seat is fixed to the lower end of the storage rack, a rotating bearing is fixed to the middle part of the upper end of the mounting seat, the stirring shaft is plugged and fixed inside the inner ring of the rotating bearing, a liquid inlet pipe connected to the side of the mounting top cylinder is provided, an upper spiral tube is provided at the middle part of the lower end of the mounting top cylinder, an upper plug-in convex ring is provided on the periphery of the lower end of the mounting top cylinder, the upper plug-in convex ring can be detachably plugged into the upper sealing socket, a lower spiral tube is provided at the upper end of the lower connecting piece, the filter membrane cylinder can be detachably screwed between the upper spiral tube and the lower spiral tube, a lower plug-in convex ring is provided at the lower end of the lower connecting piece, the lower plug-in convex ring can be detachably plugged into the avoidance through hole, and a liquid discharge pipe connected to the lower end of the lower connecting piece is provided;

[0029] The upper end of the liquid inlet pipe, the lower end of the liquid outlet pipe and the lower end of the discharge pipe are all provided with three-way solenoid valves, the other two ends of the three-way solenoid valve on the liquid inlet pipe are respectively connected to the jacket layer and the connector, the other two ends of the three-way solenoid valve at the lower end of the liquid outlet pipe are respectively connected to the ethylene glycol reflux pipeline and one end of the three-way solenoid valve at the lower end of the discharge pipe is connected through a flexible hose, and the other end of the three-way solenoid valve at the lower end of the discharge pipe is connected to the waste box through a flexible hose.

[0030] By adopting the above structure, the clean compressed air pipeline injects compressed air into the jacket layer of the liquid dispensing tank filled with ethylene glycol coolant, and after the ethylene glycol coolant is pressed into the filter membrane cylinder through the liquid inlet pipe, the stirring component stirs it, and the filtered ethylene glycol coolant enters the liquid placing cylinder component, and then flows back to the ethylene glycol reflux pipeline for repeated recycling. However, when the liquid level gauge detects that the ethylene glycol coolant level inside the liquid placing cylinder body reaches a certain position, impurities are placed inside the filter membrane cylinder at this time, and then steam is injected into the jacket layer of the empty liquid dispensing tank through the pure pressure steam pipeline to clean it, and the steam enters the filter membrane cylinder again to clean it, and the steam and the ethylene glycol coolant retained in the filter membrane cylinder form a mixed liquid, and the ethylene glycol coolant in the mixed liquid passes through the filtering separation component and the liquid placing cylinder component in turn and flows back to the ethylene glycol reflux pipeline for repeated recycling until the ethylene glycol coolant inside the liquid placing cylinder body is completely returned, and then flows back through the connection The steam is injected into the cleaning ball 2 by the head to clean the inside of the liquid cylinder body, and the waste water cleaned inside the filter membrane cylinder and the liquid cylinder body is injected into the waste box, the ethylene glycol waste liquid is discharged through the pressurized cold exhaust pipe, and the steam waste water is discharged through the pressurized hot exhaust pipe; when the filter membrane cylinder of the filter separation component needs to be replaced, the lifting component drives the stirring component and the filter separation component to rise, and the filter separation component leaves the liquid cylinder body, and the three-way solenoid valve at the lower end of the discharge pipe enters and passes through the liquid cylinder body from the avoidance through hole to release the screw connection between the filter membrane cylinder and the upper and lower spiral tubes. After replacing the new filter membrane cylinder, the lifting component drives the stirring component and the filter separation component to descend, the upper plug-in convex ring is plugged into the upper sealing socket, and the lower plug-in convex ring is plugged into the avoidance through hole, so that the filter separation component and the liquid cylinder component are sealed and engaged to continue filtering treatment, and the three-way solenoid valve at the lower end of the discharge pipe passes through the avoidance through hole and is placed below the avoidance through hole.

[0031] The semi-automatic liquid preparation process with jacket air isolation function includes the following steps: Step 1, integrity detection: steam sterilize filter 1 through a pure pressure steam pipeline, and then use an integrity detector to perform integrity detection on filter 1 to determine whether the filter element is damaged. If the test result is qualified, it means that the filter element is not damaged; if the result fails, it means that the filter element is damaged and needs to be replaced; the clean compressed air pipeline discharges the water that wets the filter element to an isolation tank, and isolates the sterile system from the sewage system through the principle of water seal in the isolation tank;

[0032] Step 2, cleaning and disinfection: The liquid preparation tank is cleaned and disinfected through the CIP disinfection supply pipeline. The connection point of the CIP disinfection supply pipeline is located at the discharge end of the liquid preparation tank to clean and disinfect the subsequent connected pipelines, as well as the filter 1 and filter 2 and the buffer tank connected to the subsequent pipelines. Then, the CIP / material pressure pipeline is used for cleaning and disinfection. Then, the waste liquid from cleaning and disinfection is refluxed through the CIP disinfection reflux pipeline. At this time, the jacket layer of the liquid preparation tank is empty, and then the raw materials are injected into the liquid preparation tank through the CIP / material pressure pipeline.

[0033] Step 3: Sterilize the jacket layer and inject refrigerant: At the same time, the pure pressure steam pipeline performs steam sterilization on the inside of the jacket layer and disinfects the air isolation mechanism. The sewage generated by the steam sterilization is discharged through the pressurized hot exhaust pipeline or the pressurized cold exhaust pipeline, and then ethylene glycol is injected into the jacket layer through the ethylene glycol supply pipeline to control the temperature of the liquid preparation tank.

[0034] Step 4, liquid preparation and mixing: the liquid preparation tank stirs and mixes the raw materials at the temperature controlled in step 3 to obtain a mixed material, the mixed material is filtered through filter 1, and then filtered through filter 2, stored in the buffer tank, and finally injected into the filling machine;

[0035] Step 5, refrigerant reflux: the clean compressed air pipeline injects compressed air into the jacket layer of the liquid distribution tank filled with ethylene glycol coolant, and after the ethylene glycol coolant is pressed into the filter separation component, the stirring component stirs, and the filtered ethylene glycol coolant enters the liquid cylinder component, and then flows back to the ethylene glycol reflux pipeline for repeated recycling. However, when the liquid level of the ethylene glycol coolant in the liquid cylinder component reaches a certain position, impurities are placed in the filter separation component, and then steam is injected into the jacket layer of the empty liquid distribution tank through the pure pressure steam pipeline to clean it, and then through The inside of the filter separation component is cleaned, and the steam and the ethylene glycol coolant retained in the filter separation component form a mixed liquid. The ethylene glycol coolant in the mixed liquid flows back to the ethylene glycol reflux pipeline through the filter separation component and the liquid cylinder component in turn, and is repeatedly recycled until the ethylene glycol coolant in the liquid cylinder component is completely refluxed, and then steam is injected into the liquid cylinder component for cleaning. The waste water from the filter separation component and the liquid cylinder component is injected into a waste material tank, and the ethylene glycol waste liquid is discharged through a pressurized cold exhaust pipeline, and the steam waste water is discharged through a pressurized hot exhaust pipeline;

[0036] Step 6, repeating steps 1 to 5, and sequentially performing integrity testing, cleaning and disinfection, sterilization, material injection, liquid preparation, and material delivery processing;

[0037] Step seven, replacement of the filter components of the air isolation mechanism: when it is necessary to replace parts of the filter separation component, the lifting component drives the stirring component and the filter separation component to rise. After replacement, the lifting component drives the stirring component and the filter separation component to descend, and the filter separation component and the liquid cartridge component are sealed and engaged to continue the filtering process.

[0038] Compared with the existing technology, the semi-automatic liquid preparation process with jacket air isolation function has the following advantages:

[0039] Through the coordination of CIP disinfection supply pipeline, CIP disinfection return pipeline, pure pressure steam pipeline, clean compressed air pipeline, CIP / material pressure pipeline, pressurized hot exhaust pipeline, pressurized cold exhaust pipeline, liquid preparation tank and buffer tank connected to the filling machine, each pipeline is reasonably laid out, which can efficiently prepare liquid, and the input and output are stable and efficient;

[0040] Through the cooperation of the integrity detector, isolation tank and filter, the integrity of filter 1 can be tested to ensure the sterility of the finished product.

[0041] The optimized refrigerant return scheme is achieved by coordinating the air isolation mechanism with the jacket layer of the liquid distribution tank, the glycol supply pipeline and the glycol return pipeline, which greatly reduces the entry of compressed air into the refrigerant return pipe, thereby reducing the impact on the closed refrigerant circulation network, improving the stability of the refrigerant system, and effectively filtering the refrigerant to ensure the purity of the refrigerant.

[0042] The filter element of the air isolation mechanism is easy to replace, which reduces the replacement time of the filter element and satisfies better filtering treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0043] Figure 1 It is a structural diagram of the liquid dispensing system of the present invention.

[0044] Figure 2 It is the left half structural diagram of the liquid dispensing system of the present invention.

[0045] Figure 3 It is the right half structural diagram of the liquid dispensing system of the present invention.

[0046] Figure 4 It is a main connection schematic diagram of the liquid dispensing tank in the present invention.

[0047] Figure 5 It is a main connection schematic diagram of the jacket air isolation of the liquid preparation tank in the present invention.

[0048] Figure 6 It is a three-dimensional structural schematic diagram of the air isolation mechanism in the present invention.

[0049] Figure 7 It is a structural schematic diagram of the lifting component in the present invention.

[0050] Figure 8 It is the structural representation of the fluid cylinder parts in the present invention.

[0051] Fig. 9 It is a schematic diagram of the upper structure of the filtering and separating component in the present invention.

[0052] Fig.10 It is a schematic diagram of the lower structure of the filtering and separating component in the present invention.

[0053] Fig.11 It is a schematic structural diagram of the stirring component in the present invention.

[0054] Fig.12 It is a process flow chart of the present invention.

[0055] In the figure, 1, lifting component; 2, stirring component; 3, three-way solenoid valve; 4, filtering and separating component; 5, liquid cylinder component; 6, waste box; 7, lifting hydraulic push rod; 8, roller; 9, lifting seat; 10, storage rack; 11, fixed stand; 12, bracket; 13, liquid outlet pipe; 14, internal sealing socket; 15, avoidance through hole; 16, connector; 17, upper sealing socket; 18, liquid cylinder body; 19, liquid level gauge; 20, installation joint; 21, rotating bearing; 22, mounting seat; 23, upper plug-in convex ring; 24, filter membrane cylinder; 25, lower connecting piece; 26, drain pipe; 27, installation top cylinder; 28, liquid inlet pipe; 29, upper screw pipe; 30, lower screw pipe; 31, lower plug-in convex ring; 32, stirring motor; 33, mounting frame; 34, stirring shaft. DETAILED DESCRIPTION

[0056] The following are specific embodiments of the present invention and the accompanying drawings to further describe the technical solution of the present invention, but the present invention is not limited to these embodiments.

[0057] like Figure 1-Figure 11As shown, the semi-automatic liquid preparation process with jacket air isolation function includes a CIP disinfection supply pipeline, a CIP disinfection return pipeline, an ethylene glycol supply pipeline, an ethylene glycol return pipeline, a pure pressure steam pipeline, a clean compressed air pipeline, a CIP / material pressure pipeline, a pressurized hot exhaust pipeline, a pressurized cold exhaust pipeline, a liquid preparation tank, an integrity detector, an air isolation mechanism, an isolation tank, and a buffer tank connected to a filling machine. The CIP disinfection supply pipeline and the liquid preparation tank and the manual The sampling valve is connected, the liquid preparation tank is connected to the CIP disinfection return pipeline and the pressurized heat exhaust pipeline, the manual sampling valve is connected to the pressurized heat exhaust pipeline, the ethylene glycol supply pipeline and the ethylene glycol return pipeline are both connected to the jacket layer of the liquid preparation tank, the ethylene glycol supply pipeline and the ethylene glycol return pipeline are connected, and the air isolation mechanism is connected to the ethylene glycol return pipeline, the air isolation mechanism is connected to the pressurized heat exhaust pipeline and the pressurized cold exhaust pipeline, the pure pressure steam pipeline and the clean compressed air pipeline are both connected to the jacket layer of the liquid preparation tank The liquid inlet end is connected, the liquid preparation tank is connected to the buffer tank through a pipeline, the CIP disinfection supply pipeline is also connected to the pipeline between the liquid preparation tank and the buffer tank, and the CIP disinfection supply pipeline connection is located at the discharge end of the liquid preparation tank, and the pipeline between the liquid preparation tank and the buffer tank is also provided with filter one and filter two, the integrity detector and the isolation tank are both connected in parallel with filter one, and the pipeline between the integrity detector and filter one is connected with filter three, the pure pressure steam pipeline is connected to the pipeline of the integrity detector and filter three, and the pure pressure steam pipeline is connected to the pressurized hot exhaust pipeline, the CIP disinfection reflux pipeline is connected between the isolation tank and the buffer tank, the pure pressure steam pipeline is connected to the ethylene glycol supply pipeline and the isolation tank, the isolation tank is connected to the pressurized cold exhaust pipeline, filter one, filter two, filter three, clean compressed air pipeline and liquid preparation tank are all connected to the pressurized cold exhaust pipeline, the CIP / material pressure pipeline is connected to the feed end of the liquid preparation tank, and the CIP disinfection reflux pipeline is connected to the pressurized hot exhaust pipeline.

[0058] Filter 1 is steam sterilized through a pure pressure steam pipeline, and then the integrity tester performs an integrity test on filter 1 to determine whether the filter element is damaged. If the test result is qualified, it means that the filter element is not damaged; if the result fails, it means that the filter element is damaged and needs to be replaced; the clean compressed air pipeline discharges the water that wets the filter element to the isolation tank, and the sterile system is isolated from the sewage system through the principle of the isolation tank water seal; the liquid preparation tank is cleaned and disinfected through the CIP disinfection supply pipeline. The CIP disinfection supply pipeline connection is located at the discharge end of the liquid preparation tank to clean and disinfect the subsequent connected pipelines, as well as the filter 1 and filter 2 connected to the subsequent pipelines and the buffer tank. Then, it is cleaned and disinfected through the CIP / material pressure pipeline, and then the cleaning and disinfection waste liquid is refluxed through the CIP disinfection reflux pipeline. At this time, the inside of the jacket layer of the liquid preparation tank is empty, and then the raw materials are injected into the liquid preparation tank through the CIP / material pressure pipeline. At the same time, the pure pressure steam pipeline is used to clean the inside of the jacket layer. Steam sterilization is performed, and the air isolation mechanism is disinfected. The sewage generated by the above steam sterilization is discharged through a pressurized hot exhaust pipeline or a pressurized cold exhaust pipeline, and then ethylene glycol is injected into the jacket layer through an ethylene glycol supply pipeline to control the temperature of the liquid preparation tank. The liquid preparation tank stirs and mixes the raw materials at the temperature control temperature to obtain a mixed material, which is filtered through filter one and then filtered through filter two, enters the buffer tank for storage, and is finally injected into the filling machine; then the clean compressed air pipeline injects air into the jacket layer of the liquid preparation tank, and after all the ethylene glycol in the jacket layer is filtered and separated through the air isolation mechanism, the ethylene glycol is refluxed and collected through the ethylene glycol reflux pipeline, and then steam is injected into the jacket layer of the empty liquid preparation tank through a pure pressure steam pipeline for cleaning, and the cleaning wastewater is injected into the waste box, the ethylene glycol waste liquid is discharged through the pressurized cold exhaust pipeline, and the steam wastewater is discharged through the pressurized hot exhaust pipeline; and the cleaning, disinfection, sterilization and filling of the liquid preparation tank are repeated.

[0059] CIP disinfection supply pipeline, CIP disinfection return pipeline, ethylene glycol supply pipeline, ethylene glycol return pipeline, pure pressure steam pipeline, clean compressed air pipeline, pressurized hot exhaust pipeline, pressurized cold exhaust pipeline are all inclined pipelines with the feed end higher than the discharge end. The inclined pipeline facilitates the internal material to flow through its own gravity and reduce energy consumption.

[0060] The ethylene glycol supply pipeline, ethylene glycol return pipeline, and the pipeline between the liquid distribution tank and the buffer tank are all cold-insulated pipelines, and the pure pressure steam pipeline is a heat-insulated pipeline. The cold-insulated pipeline is used to keep the materials inside it cold, and the heat-insulated pipeline is used to keep the materials inside it hot to ensure the temperature requirements.

[0061] A cleaning ball is provided below the feed end of the liquid dispensing tank connected to the CIP disinfection return pipeline, a heating filter is provided at one of the feed ends of the isolation tank, the clean compressed air pipeline is connected to the pressurized hot exhaust pipeline, and a heating filter is connected in parallel on the pipeline connecting the clean compressed air pipeline and the pressurized hot exhaust pipeline. The cleaning ball is used to discharge the disinfection cleaning liquid and clean the liquid dispensing tank, and the heating filter is used for heat preservation filtration.

[0062] The pipeline between the liquid distribution tank and the buffer tank is also a cold-keeping pipeline. The exhaust ends of filter 1 and filter 2 are connected to pipeline test mirrors, which are connected to the pressurized hot exhaust pipeline. Filter 1 and filter 2 are used for double filtration of product materials. When one of the filters is damaged, it can still be filtered to ensure the sterility of the product. The exhaust ends of filter 1 and filter 2 are used for exhaust. The air is injected into the pressurized hot exhaust pipeline. The pipeline test mirror observes whether the liquid inside filter 1 and filter 2 is full, that is, whether all the air is exhausted.

[0063] Filter 2 and the buffer tank are both located at the filling machine, and the cold-keeping pipeline in front of filter 2 and the cold-keeping pipeline between filter 2 and the buffer tank are connected to the pressurized hot exhaust pipeline. The cold-keeping pipelines are connected to the pressurized hot exhaust pipeline for discharging waste.

[0064] There is a magnetic stirrer inside the liquid preparation tank, an integrated sight glass and a lighting lamp on the liquid preparation tank, a feed port on the liquid preparation tank, a compressed air pipeline, a CIP disinfection supply pipeline, a pure pressure steam pipeline and a clean compressed air pipeline with a pressure of 7 bar, a CIP / material pressure pipeline with a pressure of 4 bar, and a glycol liquid temperature of the glycol supply pipeline of 2 to 7°C. Raw materials are injected into the liquid preparation tank through the feed port, and the magnetic stirrer stirs and mixes the raw materials.

[0065] The air isolation mechanism includes a lifting component 1, a waste box 6 and a liquid cylinder component 5 which are arranged in sequence. A stirring component 2 and a filter separation component 4 are fixed on the lifting component 1. The filter separation component 4 is detachably engaged in the interior of the liquid cylinder component 5. The filter separation component 4 and the liquid cylinder component 5 are both connected to the jacket layer of the liquid dispensing tank. The liquid cylinder component 5 is connected to the ethylene glycol reflux pipeline. The filter separation component 4 and the liquid cylinder component 5 are both connected to the waste box 6. The waste box 6 is connected to the pressurized cold discharge pipeline. The clean compressed air pipeline injects compressed air into the jacket layer of the liquid dispensing tank filled with ethylene glycol coolant. After the ethylene glycol coolant is pressed into the filter separation component 4, the stirring component 2 stirs it, and the filtered ethylene glycol coolant enters the liquid cylinder component 5, and then flows back to the ethylene glycol reflux pipeline for repeated recycling. However, when the liquid level of the ethylene glycol coolant in the liquid cylinder component 5 reaches a certain position, impurities are placed in the filter separation component 4. Then, steam is injected into the jacket layer of the empty liquid dispensing tank through the pure pressure steam pipeline to clean it, and then passes through the filter separation component 4 to clean it. The steam and the ethylene glycol coolant retained in the filter separation component 4 form a mixed liquid, and the ethylene glycol coolant in the mixed liquid passes through the The filter separation component 4 and the liquid cylinder component 5 are refluxed to the ethylene glycol reflux pipeline and repeatedly recycled until the ethylene glycol coolant inside the liquid cylinder component 5 is completely refluxed, and then steam is injected into the liquid cylinder component 5 for cleaning, and the waste water from cleaning the filter separation component 4 and the liquid cylinder component 5 is injected into the waste tank 6, the ethylene glycol waste liquid is discharged through the pressurized cold exhaust pipeline, and the steam waste water is discharged through the pressurized hot exhaust pipeline, thereby reducing the closed refrigerant circulation pipeline network; when it is necessary to replace the parts of the filter separation component 4, the lifting component 1 drives the stirring component 2 and the filter separation component 4 to rise, and after replacement, the lifting component 1 drives the stirring component 2 and the filter separation component 4 to descend, and the filter separation component 4 and the liquid cylinder component 5 are sealed and engaged to continue the filtering process.

[0066] The lifting component 1 includes a fixed frame 11 and a lifting seat 9. A lifting hydraulic push rod 7 is fixed on the upper end of the fixed frame 11. A plurality of rollers 8 are fixed on the lifting seat 9. The rollers 8 are rotatably arranged on the fixed frame 11. The telescopic end of the lifting hydraulic push rod 7 is fixedly connected to the lifting seat 9. A storage rack 10 is fixed on the side of the lifting seat 9. The stirring component 2 includes a stirring motor 32 and a mounting frame 33. The mounting frame 33 is fixed on the upper end of the storage rack 10. The stirring motor 32 is fixed on the upper end of the mounting frame 33. The output shaft of the stirring motor 32 passes through the mounting frame 33. A stirring shaft 34 is fixed on the output shaft of the stirring motor 32. The telescopic end of the lifting hydraulic push rod 7 drives the lifting seat 9 to rise and fall. A plurality of rollers 8 roll on the fixed frame 11. The lifting seat 9 drives the storage rack 10 to rise and fall. The lifting and falling of the storage rack 10 drives the stirring component 2 to rise and fall, so that the output shaft of the stirring motor 32 drives the stirring shaft 34 to rotate, stirring the ethylene glycol coolant inside.

[0067] The liquid cylinder component 5 includes a bracket 12, on which a liquid cylinder body 18 is fixed, an upper sealing socket 17 is provided at the upper end of the liquid cylinder body 18, a connector 16 and a mounting joint 20 are provided at the side of the liquid cylinder body 18, a cleaning ball 2 is provided inside the connector 16, a liquid level meter 19 is connected to the mounting joint 20, an internal sealing socket 14 is provided at the middle of the lower end of the liquid cylinder body 18, an avoidance through hole 15 is provided inside the internal sealing socket 14, and a lower end of the liquid cylinder body 18 is provided with a connecting head 16 and a connecting head 20 connected thereto. The filter separation component 4 includes a mounting top cylinder 27, a filter membrane cylinder 24 and a lower connecting member 25, the upper end of the mounting top cylinder 27 is fixed with a mounting seat 22, the mounting seat 22 is fixed to the lower end of the rack 10, the middle of the upper end of the mounting seat 22 is fixed with a rotating bearing 21, the stirring shaft 34 is inserted and fixed inside the inner ring of the rotating bearing 21, the side of the mounting top cylinder 27 is provided with a liquid inlet pipe 28 connected thereto, the middle of the lower end of the mounting top cylinder 27 is provided with an upper spiral tube 29, the mounting top cylinder 27 The outer periphery of the lower end is provided with an upper plug-in convex ring 23, which is detachably plugged into the upper sealing socket 17. The upper end of the lower connecting member 25 is provided with a lower screw tube 30. The filter membrane cartridge 24 is detachably screwed between the upper screw tube 29 and the lower screw tube 30. The lower end of the lower connecting member 25 is provided with a lower plug-in convex ring 31, which is detachably plugged into the avoidance through hole 15. The lower end of the lower connecting member 25 is provided with a drain pipe 26 connected thereto; the upper end of the liquid inlet pipe 28 and the liquid outlet pipe 28 are connected to each other. A three-way solenoid valve 3 is provided at the lower end of the tube 13 and the lower end of the discharge pipe 26. The other two ends of the three-way solenoid valve 3 on the liquid inlet pipe 28 are respectively connected to the jacket layer and the connector 16, the other two ends of the three-way solenoid valve 3 at the lower end of the liquid outlet pipe 13 are respectively connected to the ethylene glycol reflux pipeline and one end of the three-way solenoid valve 3 at the lower end of the discharge pipe 26 is connected through a flexible hose, and the other end of the three-way solenoid valve 3 at the lower end of the discharge pipe 26 is connected to the waste box 6 through a flexible hose.

[0068] The clean compressed air pipeline injects compressed air into the jacket layer of the liquid distribution tank containing ethylene glycol coolant, and after the ethylene glycol coolant is pressed into the filter membrane cylinder 24 through the liquid inlet pipe 28, the stirring component 2 stirs, and the ethylene glycol coolant can pass through the filter membrane cylinder 24 and enter the liquid cylinder body 18, and can flow back to the ethylene glycol reflux pipeline through the liquid outlet pipe 13, and be repeatedly recycled. However, when the liquid level meter 19 detects that the liquid level of the ethylene glycol coolant in the liquid cylinder body 18 reaches a certain position, the impurities placed in the filter membrane cylinder 24 The steam is then injected into the jacket layer of the empty liquid dispensing tank through the pure pressure steam pipeline to clean it. The steam then enters the filter membrane cylinder 24 to clean it. The steam and the ethylene glycol coolant retained in the filter membrane cylinder 24 form a mixed liquid. The ethylene glycol coolant passes through the filter membrane cylinder 24 and enters the liquid cylinder body 18, refluxes to the ethylene glycol reflux pipeline, and is repeatedly recycled until the ethylene glycol coolant in the liquid cylinder body 18 is completely refluxed. Then, steam is injected into the cleaning ball 2 through the connector 16, and the opposite The inside of the liquid cylinder body 18 is cleaned, and the waste water cleaned inside the filter membrane cylinder 24 and the inside of the liquid cylinder body 18 is injected into the waste box 6, the ethylene glycol waste liquid is discharged through the pressurized cold exhaust pipeline, and the steam waste water is discharged through the pressurized hot exhaust pipeline; when it is necessary to replace the filter membrane cylinder 24 of the filter separation component 4, the lifting component 1 drives the stirring component 2 and the filter separation component 4 to rise, and the filter separation component 4 leaves the liquid cylinder body 18, and the three-way solenoid valve 3 at the lower end of the discharge pipe 26 enters from the avoidance through hole 15 and passes through the liquid cylinder body 18. , release the threaded connection between the filter membrane cartridge 24 and the upper screw tube 29 and the lower screw tube 30. After replacing the new filter membrane cartridge 24, the lifting component 1 drives the stirring component 2 and the filter separation component 4 to descend, the upper plug-in convex ring 23 is plugged into the upper sealing socket 17, and the lower plug-in convex ring 31 is plugged into the avoidance hole 15, so that the filter separation component 4 and the liquid cartridge component 5 are sealed and engaged to continue the filtration process, and the three-way solenoid valve 3 at the lower end of the discharge pipe 26 passes through the avoidance hole 15 and is placed below the avoidance hole 15.

[0069] like Fig.12 As shown, the semi-automatic liquid preparation process with jacket air isolation function includes the following steps:

[0070] Step 1, integrity test: steam sterilize filter 1 through pure pressure steam pipeline, and then use integrity tester to test filter 1 to determine whether the filter element is damaged. If the test result is qualified, it means that the filter element is not damaged; if the result fails, it means that the filter element is damaged and needs to be replaced; the clean compressed air pipeline discharges the water that wets the filter element to the isolation tank, and the sterile system is isolated from the sewage system through the principle of water seal of the isolation tank;

[0071] Step 2, cleaning and disinfection: The liquid preparation tank is cleaned and disinfected through the CIP disinfection supply pipeline. The connection point of the CIP disinfection supply pipeline is located at the discharge end of the liquid preparation tank to clean and disinfect the subsequent connected pipelines, as well as the filter 1 and filter 2 and the buffer tank connected to the subsequent pipelines. Then, the CIP / material pressure pipeline is used for cleaning and disinfection. Then, the waste liquid from cleaning and disinfection is refluxed through the CIP disinfection reflux pipeline. At this time, the jacket layer of the liquid preparation tank is empty, and then the raw materials are injected into the liquid preparation tank through the CIP / material pressure pipeline.

[0072] Step 3: Sterilize the jacket layer and inject refrigerant: At the same time, the pure pressure steam pipeline performs steam sterilization on the inside of the jacket layer and disinfects the air isolation mechanism. The sewage generated by the steam sterilization is discharged through the pressurized hot exhaust pipeline or the pressurized cold exhaust pipeline, and then ethylene glycol is injected into the jacket layer through the ethylene glycol supply pipeline to control the temperature of the liquid preparation tank.

[0073] Step 4, liquid preparation and mixing: the liquid preparation tank stirs and mixes the raw materials at the temperature controlled in step 3 to obtain a mixed material, the mixed material is filtered through filter 1, and then filtered through filter 2, stored in the buffer tank, and finally injected into the filling machine;

[0074] Step 5, refrigerant reflux: the clean compressed air pipeline injects compressed air into the jacket layer of the liquid dispensing tank containing ethylene glycol coolant, and after the ethylene glycol coolant is pressed into the filter membrane cylinder 24 through the liquid inlet pipe 28, the stirring component 2 stirs, and the ethylene glycol coolant can pass through the filter membrane cylinder 24 into the liquid cylinder body 18, and can flow back to the ethylene glycol reflux pipeline through the liquid outlet pipe 13, and be repeatedly recycled. However, when the liquid level meter 19 detects that the liquid level of the ethylene glycol coolant in the liquid cylinder body 18 reaches a certain position, impurities are placed in the filter membrane cylinder 24 at this time, and then steam is injected into the jacket layer of the empty liquid dispensing tank through the pure pressure steam pipeline to impurities. Cleaning, the steam then enters the filter membrane cylinder 24 to clean it, the steam and the ethylene glycol coolant retained in the filter membrane cylinder 24 form a mixed liquid, the ethylene glycol coolant passes through the filter membrane cylinder 24 into the liquid cylinder body 18, refluxes to the ethylene glycol reflux pipeline, and is repeatedly recycled until the ethylene glycol coolant in the liquid cylinder body 18 is completely refluxed, and then the steam is injected into the cleaning ball 2 through the connector 16 to clean the inside of the liquid cylinder body 18, and the waste water cleaned from the filter membrane cylinder 24 and the liquid cylinder body 18 is injected into the waste tank 6, the ethylene glycol waste liquid is discharged through the pressurized cold exhaust pipeline, and the steam waste water is discharged through the pressurized hot exhaust pipeline;

[0075] Step 6, repeating steps 1 to 5, and sequentially performing integrity testing, cleaning and disinfection, sterilization, material injection, liquid preparation, and material delivery processing;

[0076] Step seven, replacement of the filter element of the air isolation mechanism: when the filter membrane cartridge 24 of the filter separation component 4 needs to be replaced, the lifting component 1 drives the stirring component 2 and the filter separation component 4 to rise, the filter separation component 4 leaves the liquid cartridge body 18, and the three-way solenoid valve 3 at the lower end of the discharge pipe 26 enters from the avoidance hole 15 and passes through the liquid cartridge body 18, releasing the threaded connection between the filter membrane cartridge 24 and the upper screw tube 29 and the lower screw tube 30. After replacing the new filter membrane cartridge 24, the lifting component 1 drives the stirring component 2 and the filter separation component 4 to descend, the upper plug-in convex ring 23 is plugged into the upper sealing socket 17, and the lower plug-in convex ring 31 is plugged into the avoidance hole 15, so that the filter separation component 4 and the liquid cartridge component 5 are sealed and engaged to continue the filtering process, and the three-way solenoid valve 3 at the lower end of the discharge pipe 26 passes through the avoidance hole 15 and is placed below the avoidance hole 15.

[0077] In summary, through the coordination of CIP disinfection supply pipeline, CIP disinfection return pipeline, pure pressure steam pipeline, clean compressed air pipeline, CIP / material pressure pipeline, pressurized hot exhaust pipeline, pressurized cold exhaust pipeline, liquid preparation tank and buffer tank connected to the filling machine, the layout of each pipeline is reasonable, liquid preparation can be carried out efficiently, and the input and output are stable and efficient;

[0078] Through the cooperation of the integrity detector, isolation tank and filter, the integrity of filter 1 can be tested to ensure the sterility of the finished product.

[0079] The optimized refrigerant return scheme is achieved by coordinating the air isolation mechanism with the jacket layer of the liquid distribution tank, the glycol supply pipeline and the glycol return pipeline, which greatly reduces the entry of compressed air into the refrigerant return pipe, thereby reducing the impact on the closed refrigerant circulation network, improving the stability of the refrigerant system, and effectively filtering the refrigerant to ensure the purity of the refrigerant.

[0080] The filter element of the air isolation mechanism is easy to replace, which reduces the replacement time of the filter element and satisfies better filtering treatment.

[0081] The specific embodiments described herein are merely examples of the spirit of the present invention. Those skilled in the art may make various modifications or additions to the specific embodiments described or replace them in similar ways, but they will not deviate from the spirit of the present invention or exceed the scope defined by the appended claims.

Claims

1. A semi-automatic liquid preparation process with jacket air isolation function, characterized in that: The following steps are involved: Step 1, integrity test: steam sterilize filter 1 through pure pressure steam pipeline, and then use integrity tester to test filter 1 to determine whether the filter element is damaged. If the test result is qualified, it means that the filter element is not damaged; if the result fails, it means that the filter element is damaged and needs to be replaced; the clean compressed air pipeline discharges the water that wets the filter element to the isolation tank, and the sterile system is isolated from the sewage system through the principle of water seal of the isolation tank; Step 2, cleaning and disinfection: The liquid preparation tank is cleaned and disinfected through the CIP disinfection supply pipeline. The connection point of the CIP disinfection supply pipeline is located at the discharge end of the liquid preparation tank to clean and disinfect the subsequent connected pipelines, as well as the filter 1 and filter 2 and the buffer tank connected to the subsequent pipelines. Then, the CIP / material pressure pipeline is used for cleaning and disinfection. Then, the waste liquid from cleaning and disinfection is refluxed through the CIP disinfection reflux pipeline. At this time, the jacket layer of the liquid preparation tank is empty, and then the raw materials are injected into the liquid preparation tank through the CIP / material pressure pipeline. Step 3: Sterilize the jacket layer and inject refrigerant: At the same time, the pure pressure steam pipeline performs steam sterilization on the inside of the jacket layer and disinfects the air isolation mechanism. The sewage generated by the steam sterilization is discharged through the pressurized hot exhaust pipeline or the pressurized cold exhaust pipeline, and then ethylene glycol is injected into the jacket layer through the ethylene glycol supply pipeline to control the temperature of the liquid preparation tank. Step 4, liquid preparation and mixing: the liquid preparation tank stirs and mixes the raw materials at the temperature controlled in step 3 to obtain a mixed material, the mixed material is filtered through filter 1, and then filtered through filter 2, stored in the buffer tank, and finally injected into the filling machine; Step 5, refrigerant reflux: the clean compressed air pipeline injects compressed air into the jacket layer of the liquid distribution tank containing ethylene glycol coolant, and after the ethylene glycol coolant is forced into the filter separation component (4), the stirring component (2) stirs, and the filtered ethylene glycol coolant enters the liquid cylinder component (5), and then flows back to the ethylene glycol reflux pipeline for repeated recycling. However, when the ethylene glycol coolant level in the liquid cylinder component (5) reaches a certain position, impurities are placed in the filter separation component (4), and then steam is injected into the jacket layer of the empty liquid distribution tank through the pure pressure steam pipeline to clean it, and then it passes through the filter separation component. (4) is cleaned, steam and ethylene glycol coolant retained in the filter separation component (4) form a mixed liquid, and the ethylene glycol coolant in the mixed liquid flows back to the ethylene glycol return pipeline through the filter separation component (4) and the liquid cylinder component (5) in turn, and is repeatedly recycled until the ethylene glycol coolant in the liquid cylinder component (5) is completely returned, and then steam is injected into the liquid cylinder component (5) for cleaning, and the waste water from cleaning the filter separation component (4) and the liquid cylinder component (5) is injected into the waste tank (6), and the ethylene glycol waste liquid is discharged through the pressurized cold exhaust pipeline, and the steam waste water is discharged through the pressurized hot exhaust pipeline; Step 6, repeating steps 1 to 5, and sequentially performing integrity testing, cleaning and disinfection, sterilization, material injection, liquid preparation, and material delivery processing; Step 7, replacement of the filter element of the air isolation mechanism: when it is necessary to replace the parts of the filter separation component (4), the lifting component (1) drives the stirring component (2) and the filter separation component (4) to rise. After replacement, the lifting component (1) drives the stirring component (2) and the filter separation component (4) to descend, and the filter separation component (4) and the liquid cartridge component (5) are sealed and engaged to continue the filtering process.

2. A semi-automatic liquid preparation process with jacket air isolation function according to claim 1, characterized in that: The equipment of the liquid preparation process includes a CIP disinfection supply pipeline, a CIP disinfection return pipeline, an ethylene glycol supply pipeline, an ethylene glycol return pipeline, a pure pressure steam pipeline, a clean compressed air pipeline, a CIP / material pressure pipeline, a pressurized hot exhaust pipeline, a pressurized cold exhaust pipeline, a liquid preparation tank, an integrity detector, an air isolation mechanism, an isolation tank, and a buffer tank connected to the filling machine. The CIP disinfection supply pipeline is connected to the liquid preparation tank and a manual sampling valve connected to the liquid preparation tank. The liquid preparation tank is connected to The CIP disinfection return pipeline is connected to the pressurized heat exhaust pipeline, the manual sampling valve is connected to the pressurized heat exhaust pipeline, the ethylene glycol supply pipeline and the ethylene glycol return pipeline are both connected to the jacket layer of the liquid distribution tank, the ethylene glycol supply pipeline and the ethylene glycol return pipeline are connected, and the air isolation mechanism is connected to the ethylene glycol return pipeline, the air isolation mechanism is connected to the pressurized heat exhaust pipeline and the pressurized cold exhaust pipeline, the pure pressure steam pipeline and the clean compressed air pipeline are both connected to the liquid inlet end of the jacket layer of the liquid distribution tank The liquid preparation tank is connected to the buffer tank through a pipeline, the CIP disinfection supply pipeline is also connected to the pipeline between the liquid preparation tank and the buffer tank, and the connection of the CIP disinfection supply pipeline is located at the discharge end of the liquid preparation tank, and filters 1 and 2 are also provided on the pipeline between the liquid preparation tank and the buffer tank. The integrity detector and the isolation tank are both connected to filter 1 in parallel, and the pipeline between the integrity detector and filter 1 is connected to filter 3. The pure pressure steam pipeline is connected to the pipeline of the integrity detector and filter 3, and the pure pressure steam pipeline is connected to the pressurized hot exhaust pipeline. The CIP disinfection reflux pipeline is connected between the isolation tank and the buffer tank, the pure pressure steam pipeline is connected to the ethylene glycol supply pipeline and the isolation tank, the isolation tank is connected to the pressurized cold exhaust pipeline, filter 1, filter 2, filter 3, clean compressed air pipeline and liquid preparation tank are all connected to the pressurized cold exhaust pipeline, the CIP / material pressure pipeline is connected to the feed end of the liquid preparation tank, and the CIP disinfection reflux pipeline is connected to the pressurized hot exhaust pipeline.

3. A semi-automatic liquid preparation process with jacket air isolation function according to claim 2, characterized in that: The CIP disinfection supply pipeline, CIP disinfection return pipeline, ethylene glycol supply pipeline, ethylene glycol return pipeline, pure pressure steam pipeline, clean compressed air pipeline, pressurized hot exhaust pipeline, and pressurized cold exhaust pipeline are all inclined pipelines with the feed end higher than the discharge end; the ethylene glycol supply pipeline, ethylene glycol return pipeline, and the pipeline between the liquid preparation tank and the buffer tank are all cold-insulating pipelines, and the pure pressure steam pipeline is an insulated pipeline.

4. A semi-automatic liquid preparation process with jacket air isolation function according to claim 3, characterized in that: A cleaning ball is provided below the feed end of the liquid distribution tank connected to the CIP disinfection return pipeline, a heating filter is provided at one of the feed ends of the isolation tank, the clean compressed air pipeline and the pressurized hot exhaust pipeline are connected, and a heating filter is connected in parallel on the pipeline connecting the clean compressed air pipeline and the pressurized hot exhaust pipeline.

5. A semi-automatic liquid preparation process with jacket air isolation function according to claim 4, characterized in that: The pipeline between the liquid distribution tank and the buffer tank is also a cold-keeping pipeline. The exhaust ends of filter 1 and filter 2 are connected with pipeline test mirrors, and the pipeline test mirrors are connected with the pressurized hot exhaust pipeline.

6. A semi-automatic liquid preparation process with jacket air isolation function according to claim 5, characterized in that: The filter 2 and the buffer tank are both located at the filling machine, and the cold-keeping pipeline on the front side of the filter 2 and the cold-keeping pipeline between the filter 2 and the buffer tank are both connected to the pressurized heat exhaust pipeline.

7. A semi-automatic liquid preparation process with jacket air isolation function according to claim 6, characterized in that: A magnetic stirrer is provided inside the liquid preparation tank, an integrated sight glass and a lighting lamp are provided on the liquid preparation tank, a feed port is provided on the liquid preparation tank, the pressure of the compressed air pipeline, the CIP disinfection supply pipeline, the pure pressure steam pipeline and the clean compressed air pipeline is 7 bar, the pressure of the CIP / material pressure pipeline is 4 bar, and the ethylene glycol liquid temperature of the ethylene glycol supply pipeline is 2-7°C.

8. A semi-automatic liquid preparation process with jacket air isolation function according to claim 7, characterized in that: The air isolation mechanism comprises a lifting component (1), a waste box (6) and a liquid cartridge component (5) which are arranged in sequence; a stirring component (2) and a filtering and separating component (4) are fixed on the lifting component (1); the filtering and separating component (4) is detachably engaged in the interior of the liquid cartridge component (5); the filtering and separating component (4) and the liquid cartridge component (5) are both connected to the jacket layer of the liquid dispensing tank; the liquid cartridge component (5) is connected to the ethylene glycol reflux pipeline; the filtering and separating component (4) and the liquid cartridge component (5) are both connected to the waste box (6); and the waste box (6) is connected to the pressurized cold discharge pipeline.

9. A semi-automatic liquid preparation process with jacket air isolation function according to claim 8, characterized in that: The lifting component (1) comprises a fixed frame (11) and a lifting seat (9), a lifting hydraulic push rod (7) is fixed to the upper end of the fixed frame (11), a plurality of rollers (8) are fixed to the lifting seat (9), the rollers (8) are rotatably arranged on the fixed frame (11), the telescopic end of the lifting hydraulic push rod (7) is fixedly connected to the lifting seat (9), and a storage rack (10) is fixed to the side of the lifting seat (9); The stirring component (2) comprises a stirring motor (32) and a mounting frame (33); the mounting frame (33) is fixed to the upper end of the storage rack (10); the stirring motor (32) is fixed to the upper end of the mounting frame (33); the output shaft of the stirring motor (32) passes through the mounting frame (33); and a stirring shaft (34) is fixed to the output shaft of the stirring motor (32).

10. A semi-automatic liquid preparation process with jacket air isolation function according to claim 9, characterized in that: The liquid cylinder component (5) comprises a bracket (12), a liquid cylinder body (18) is fixed on the bracket (12), an upper sealing socket (17) is provided at the upper end of the liquid cylinder body (18), a connecting head (16) and a mounting joint (20) are provided at the side of the liquid cylinder body (18), a cleaning ball 2 is provided inside the connecting head (16), a liquid level meter (19) is connected to the mounting joint (20), an internal sealing socket (14) is provided at the middle of the lower end of the liquid cylinder body (18), an avoidance through hole (15) is provided inside the internal sealing socket (14), and a liquid outlet pipe (13) is provided at the lower end of the liquid cylinder body (18) and is connected to the liquid cylinder body (18); The filtering and separating component (4) comprises a mounting top cylinder (27), a filtering membrane cylinder (24) and a lower connecting piece (25); a mounting seat (22) is fixed to the upper end of the mounting top cylinder (27); the mounting seat (22) is fixed to the lower end of the storage rack (10); a rotating bearing (21) is fixed to the middle of the upper end of the mounting seat (22); the stirring shaft (34) is inserted and fixed inside the inner ring of the rotating bearing (21); a liquid inlet pipe (28) is provided on the side of the mounting top cylinder (27) and is connected thereto; an upper spiral tube (29) is provided in the middle of the lower end of the mounting top cylinder (27); An upper plug-in convex ring (23) is provided on the periphery of the lower end of the cylinder (27), and the upper plug-in convex ring (23) is detachably plugged into the interior of the upper sealing socket (17); a lower screw tube (30) is provided on the upper end of the lower connecting piece (25); the filter membrane cylinder (24) is detachably screwed between the upper screw tube (29) and the lower screw tube (30); a lower plug-in convex ring (31) is provided on the lower end of the lower connecting piece (25), and the lower plug-in convex ring (31) is detachably plugged into the interior of the avoidance through hole (15); and a liquid discharge pipe (26) is provided at the lower end of the lower connecting piece (25) and is connected thereto; The upper end of the liquid inlet pipe (28), the lower end of the liquid outlet pipe (13) and the lower end of the liquid discharge pipe (26) are all provided with a three-way solenoid valve (3); the other two ends of the three-way solenoid valve (3) on the liquid inlet pipe (28) are respectively connected to the jacket layer and the connector (16); the other two ends of the three-way solenoid valve (3) at the lower end of the liquid outlet pipe (13) are respectively connected to the ethylene glycol reflux pipeline and one end of the three-way solenoid valve (3) at the lower end of the liquid discharge pipe (26) is connected via a flexible hose; the other end of the three-way solenoid valve (3) at the lower end of the liquid discharge pipe (26) is connected to the waste box (6) via a flexible hose.

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