A medicine-food homologous composition for allergic rhinitis and its preparation and preparation method

Abstract

The present invention provides a medicine-food homologous composition for allergic rhinitis and its preparation and preparation method, and belongs to the technical field of Chinese medicine preparations. The present invention, through the study of the treatment mechanism and treatment principle of allergic rhinitis, based on the characteristics of the onset of allergic rhinitis in children, selects the reasonable compatibility of medicine-food homologous medicinal materials such as houttuynia, angelica dahurica, honeysuckle, coix seed, polygonatum, astragalus, codonopsis, bergamot, ebony, platycodon, mint, licorice, and honey, and highlights the efficacy of the medicine in lung purgation, heat-clearing and detoxification, improving spleen deficiency and enhancing immunity. Multiple raw materials are synergistically compatible to jointly improve the related symptoms of allergic rhinitis such as nasal congestion, nasal itching, eye itching, clear nasal discharge, and hyposmia. It has been verified by experiments that the composition has a definite efficacy, and the clinical behavior index, blood IgE index and comprehensive index are all good, providing a long-term safe and non-toxic treatment plan for patients with allergic rhinitis, which is particularly suitable for the use of children.

Description

Technical Field

[0001] The present application relates to the technical field of traditional Chinese medicine preparations, and in particular to a medicine-food combination for allergic rhinitis, a preparation thereof, and a preparation method thereof. Background Art

[0002] Allergic rhinitis, also known as allergic rhinitis, is a common chronic nasal mucosal disease characterized by an excessive immune response to specific allergens, which usually involves IgE antibodies in the immune system. Common allergens include pollen, dust mites, pet dander, mold spores, etc. When the above allergens enter the nasal cavity, they will produce a series of symptoms. The main symptoms of allergic rhinitis include frequent and strong sneezing, runny nose, nasal congestion, nasal itching, red and itchy eyes, and itchy throat.

[0003] Allergic rhinitis is a common and highly prevalent disease, and the treatment methods are relatively mature, which usually include identifying and avoiding contact with allergens in life, preventing and reducing the occurrence of allergic reactions from the root. The most common treatment method is drug therapy, such as the use of antihistamines, such as over-the-counter loratadine, cetirizine and other non-sedating antihistamines can relieve symptoms such as sneezing, runny nose and nasal itching; the use of nasal corticosteroid sprays such as fluticasone and budesonide, through the external application of the above drugs can effectively reduce the related inflammation of the nasal mucosa. It also includes decongestant treatment, such as pseudoephedrine, which can temporarily relieve nasal congestion, and immunotherapy, which gradually increases the dose of allergens by subcutaneous injection or sublingual drops, so as to improve the patient's tolerance to specific allergens; it can also include taking Chinese medicine preparations for treatment. Chinese medicine treatment is mainly based on traditional Chinese medicine theory, and achieves the purpose of treatment by adjusting the internal balance of the human body. Common Chinese medicines include magnolia, mint, astragalus and white atractylodes. In addition, lifestyle changes, such as keeping indoor air clean, using air purifiers, regularly replacing filters, and keeping the indoor environment clean and dry are all common ways of daily prevention.

[0004] However, existing treatment methods have problems to varying degrees. For example, in Western medicine treatment, drugs including hormones, decongestants, antihistamines, antiallergic drugs, surgery, etc. have side effects. In Chinese medicine treatment, the Chinese medicine liquid is too bitter, and some people find it difficult to persist, especially children who find it difficult to swallow. The current rhinitis conditioning products on the market are particularly harmful to the nasal mucosa when applied externally, so they are not advisable.

[0005] For example, the prior art with publication number CN115708859A discloses a pharmaceutical composition for treating allergic rhinitis, in which ingredients including astragalus, atractylodes, saposhnikovia, magnolia, and angelica are used in the raw materials; the pharmaceutical composition for treating allergic rhinitis in the patent application with publication number CN 114949082A also uses Chinese medicinal ingredients such as ephedra, fried saposhnikovia, bombyx batryticatus, and Xanthium sibiricum. Although the patent application with publication number CN104855984A uses many raw materials of medicinal and edible origin, the types of raw materials are as high as hundreds. In summary, the existing research has not used raw materials of medicinal and edible origin to obtain pharmaceutical products for allergic rhinitis through reasonable compatibility.

[0006] The number of people suffering from rhinitis in my country is increasing year by year, and the age of the rhinitis population is showing a trend of younger age. Children are gradually becoming the main patients, and early intervention treatment is needed. The above-mentioned Western medicine and traditional Chinese medicine treatment methods have many adverse effects, which obviously no longer meet the medication needs of children. Based on the above problems, for the health and medication safety of children, and with the increasing attention paid by the country to the use of medicinal and edible ingredients, the present invention is proposed under the guidance of the foundation of traditional Chinese medicine, in order to solve many problems existing in the prior art. Summary of the invention

[0007] In view of the above problems, the present invention studies the pathogenesis and treatment principles of allergic rhinitis, based on the characteristics of allergic rhinitis in children, and through the rational combination of medicinal materials that are both medicine and food, highlights the effects of the drugs on lung-purgation, heat-clearing and detoxification, improvement of spleen deficiency and enhancement of immunity. Multiple raw materials are synergistically combined to jointly improve the related symptoms of allergic rhinitis such as nasal congestion, nasal itching, eye itching, clear nasal discharge, decreased sense of smell, etc.

[0008] In the initial stage of treatment, allergic rhinitis needs to be treated with wind-clearing and relieving symptoms to dispel wind evil and relieve nasal itching and sneezing. For allergic rhinitis of lung heat type, lung heat needs to be cleared. For allergic rhinitis of spleen deficiency type, the main treatment principle is to strengthen spleen and stomach function and improve body tolerance. For allergic rhinitis of yin deficiency type, the main treatment principle should be to nourish lung yin and relieve dry nose and throat. Children should pay more attention to improving immunity and spleen and stomach function during treatment because of their low immunity and spleen deficiency.

[0009] When the raw materials of the present invention are matched, the five steps of green care mode are first created for various stubborn nasal diseases, including nourishment, exorcism, support, fumigation and training. Among them, a, selecting acupuncture points along the meridians - for maintenance; b, warming the meridians and unblocking the collaterals - for exorcism; c, regulating the inside and nourishing the outside - for strengthening the body; d, removing dampness and expelling cold - by fumigation; e, helping to resist allergies - outdoor training. Experiments have confirmed that the customer satisfaction with rhinitis is very high.

[0010] On the one hand, the present invention provides a medicine-food composition for allergic rhinitis, characterized in that the raw materials and weight portions in the composition are: 25-40 parts of houttuynia cordata, 15-40 parts of angelica dahurica, 15-40 parts of honeysuckle, 20-35 parts of coix seeds, 8-30 parts of polygonatum, 10-30 parts of astragalus, 4-20 parts of codonopsis pilosula, 3-18 parts of citron, 6-20 parts of ebony, 6-20 parts of platycodon, 3-25 parts of mint, 3-20 parts of licorice, and 10-40 parts of honey.

[0011] As a preferred scheme, the raw materials and their weight proportions are further as follows: 28-36 parts of Houttuynia cordata, 20-30 parts of Angelica dahurica, 20-30 parts of Honeysuckle, 23-32 parts of Coix seeds, 10-25 parts of Polygonatum sibiricum, 13-26 parts of Astragalus, 8-16 parts of Codonopsis pilosula, 5-15 parts of Citron, 8-18 parts of Ebony plum, 8-16 parts of Platycodon grandiflorum, 5-20 parts of mint, 6-16 parts of Licorice, and 20-35 parts of honey.

[0012] As a preferred scheme, the raw materials and their weight proportions are further as follows: 32 parts of Houttuynia cordata, 25 parts of Angelica dahurica, 25 parts of Honeysuckle, 27 parts of Coix seeds, 18 parts of Polygonatum sibiricum, 20 parts of Astragalus, 10 parts of Codonopsis pilosula, 12 parts of Citron, 14 parts of Prunus mume, 15 parts of Platycodon grandiflorum, 13 parts of mint, 11 parts of Licorice, and 28 parts of honey.

[0013] The houttuynia cordata in the present invention enters the lungs to clear away heat and detoxify, eliminate carbuncle and swelling, play a major heat-clearing and detoxifying effect, can enter the lungs to descend, treat lung and airway discomfort caused by allergic rhinitis, eliminate excess gas, relieve patient discomfort, and play a major role.

[0014] Angelica dahurica enters the large intestine, clears the stomach and clears the qi, relieves exterior symptoms and dispels cold, dispels wind and relieves pain, clears the nasal passages, reduces swelling and clears the passages, and is effective for acute and chronic rhinitis, nasal congestion and runny nose. It is a commonly used medicine for the treatment of allergic rhinitis.

[0015] Honeysuckle is sweet and cold in nature, dispels wind-heat, cools blood and stops bleeding. It has the effects of clearing away heat and detoxifying, relieving inflammation and reducing swelling. It is mainly used to treat various infectious diseases such as exogenous wind-heat or febrile fever, heatstroke, hot and toxic bloody diarrhea, carbuncles, furuncles, and throat paralysis.

[0016] Coix seed belongs to the spleen, stomach, and lung meridians, is beneficial to water and dampness, has the effects of strengthening the spleen and stopping diarrhea, removing numbness, discharging pus, detoxifying and dispersing nodules, and has the effect of enhancing children's immunity.

[0017] Polygonatum sibiricum enters the spleen, lungs and kidneys, and has the effects of replenishing qi and nourishing yin, strengthening the spleen and stomach, moistening the lungs and producing body fluid, moistening dryness and relieving cough, and benefiting the kidneys and replenishing yin.

[0018] Astragalus enters the lungs and spleen, and has the effects of replenishing qi and raising yang, benefiting the body's defense system and strengthening the exterior, promoting diuresis and reducing swelling, and promoting body fluid and nourishing blood.

[0019] Codonopsis pilosula is sweet in taste and neutral in nature. It enters the spleen and lung meridians and has the effects of strengthening the spleen and lungs, nourishing blood and producing body fluids.

[0020] Buddha's hand enters the liver, spleen, and stomach meridians, and has many medicinal functions such as regulating qi and resolving phlegm, stopping vomiting and relieving bloating, soothing the liver and strengthening the spleen, and harmonizing the stomach.

[0021] Black plum enters the lungs, liver, spleen, and large intestine, and has the effects of promoting fluid production and astringing the lungs, treating chronic cough due to lung deficiency, cough due to lung dryness, and nasal discomfort. It has a good effect on improving nasal congestion and runny nose, and allergic rhinitis runny nose caused by weak lung qi.

[0022] Platycodon enters the lungs to clear the lungs and eliminate phlegm, relieve sore throat and detoxify. It is used for cough with excessive phlegm, chest tightness, sore throat, hoarseness, lung abscess with pus vomiting, and pus-filled sores that do not break.

[0023] Mint has the effects of dispersing wind-heat, detoxifying and clearing rashes, and clearing the head; when used in patients with allergic rhinitis, it can effectively alleviate symptoms.

[0024] Licorice enters the heart, lungs, spleen and stomach, and has many functions such as replenishing the middle qi, moistening the lungs and relieving cough, clearing away heat and detoxifying, relieving acute pain, etc.

[0025] On the other hand, the present invention also provides a preparation of a medicine-food combination for allergic rhinitis, which is prepared using the above-mentioned combination as an active ingredient.

[0026] Preferably, the preparation of the present invention is in the form of tablets, granules, capsules or oral liquid.

[0027] The third aspect of the present invention provides a method for preparing a medicine-food combination for allergic rhinitis, comprising the following steps:

[0028] 1) Weigh each raw material by weight, and coarsely grind the other Chinese medicinal ingredients with medicinal and edible properties except honey to obtain pre-treated raw materials;

[0029] 2) adding 5-8 times the weight of the raw materials to the pretreated Houttuynia cordata, honeysuckle, coix seed, polygonatum, astragalus, codonopsis, ebony, and liquorice, extracting at 50-70° C. for 20 minutes, filtering, separating the filtrate, adding 4-6 times the weight of the raw materials to the filter residue again, continuing to extract at 50-70° C. for 20 minutes, filtering to obtain a filtrate, and combining the two filtrates to obtain a pretreated product A;

[0030] Add 4-8 times the amount of water used as the raw materials to the pretreated angelica, bergamot, platycodon and mint, extract the volatile oil by steam distillation, collect the volatile oil B after condensation treatment by a multi-stage condensation system, continue to collect the distilled aqueous solution, and obtain the treated product C after filtration;

[0031] 3) The pre-treated product A and the treated product C are concentrated under reduced pressure, mixed with volatile oil B, further concentrated, and further stirred and mixed with honey to obtain an active extract;

[0032] 4) Using the active extract obtained in step 3) as a raw material, a preparation of a medicine-food combination for allergic rhinitis is prepared.

[0033] Preferably, in step 3), the solution is further concentrated to a relative density of 1.2-1.3.

[0034] Further preferably, the rotation speed of the stirring and mixing in step 3) is 500-800 rpm.

[0035] Compared with the prior art, the technical solution of the present invention includes at least the following beneficial effects:

[0036] (1) The raw material combination of the present invention is made of natural plants, has no toxic side effects, is highly safe, and is a medicinal material with medicinal and edible properties promulgated by the National Health Commission. No drug ingredients are used at all, thus avoiding the poor taste and toxic side effects caused by the use of Chinese medicine raw materials. The present invention is more suitable for patients with allergic rhinitis, especially children with rhinitis.

[0037] (2) In the combination of raw materials, the combination of raw materials is selected according to the symptoms of specific allergic rhinitis. In the formula, Houttuynia cordata enters the lungs to descend, clear away heat and detoxify, and is pungent to disperse knots, eliminate carbuncle and discharge pus to open the nasal passages; Angelica dahurica enters the Yangming meridian to raise clear qi, relieve the exterior and dissipate cold, open the nasal passages, clear away heat and detoxify, and reduce swelling and open the orifices; Honeysuckle enters the lungs and stomach, and together exerts the effect of anti-inflammatory and heat-clearing; Coix seed strengthens the spleen and eliminates dampness, and enhances immunity. The above are the main drugs; the ministers are Polygonatum sibiricum to nourish the kidney and liver, Astragalus membranaceus to replenish qi and raise yang, consolidate the exterior and stop sweating, sweet and warm, and replenish the positive qi; Codonopsis pilosula to replenish qi and consolidate the exterior and can reduce allergic reactions; Citron to soothe the liver and relieve depression, and regulate the spleen and stomach. The above drugs have the ability to enhance the ability to expel toxins and discharge pus; the auxiliary is Prunus mume with sweet and sour properties to astringe yin and harmonize the camp; Platycodon grandiflorum carries the drug upward to clear the lungs and discharge pus, and mint relieves symptoms; Licorice is used to harmonize the medicinal properties. The honey in the prescription contains a variety of enzymes and minerals, which help to enhance immunity, improve the taste of the medicine, and make it easier to take. The combination of the medicines can disperse wind, strengthen the exterior, promote lung function, clear away heat and detoxify, improve spleen and stomach weakness, and enhance immunity, thus achieving the beneficial effect of improving the symptoms of allergic rhinitis.

[0038] (3) The raw material combination of the present invention, starting from the overall view and holistic view of traditional Chinese medicine theory, is committed to regulating the body's immune system, so that the body's own self-healing ability is strengthened, so as to prevent problems before they occur. In the raw material combination, according to the characteristics of children's allergic rhinitis, the Chinese medicine lung-clearing and qi-lowering treatment method is used. First, the lung and airway discomfort caused by allergic rhinitis is treated, excess gas is eliminated, and the patient's discomfort is relieved, thereby helping to prolong the breathing time and intensity. This therapy can also enhance the body's resistance. In addition, the prescription focuses on the use of coix seed as the main medicine and Houttuynia cordata to enhance the body's resistance. The honey used not only improves the taste, but also has the effect of enhancing resistance. For children with low immunity, it has outstanding effects by focusing on lung-clearing, heat-clearing and detoxification, improving spleen deficiency and enhancing immunity.

[0039] (4) In the preparation of drug preparations, the present invention fully considers the chemical properties, thermal stability, polarity and cost-effectiveness of the target compound, and adjusts the extraction methods of different raw materials according to the differences in raw materials. For example, hot water is used to fully extract Houttuynia cordata, Coix seeds, honeysuckle, Polygonatum sibiricum, Astragalus, Codonopsis pilosula, Prunus mume and Licorice. For raw materials rich in volatile oil active ingredients such as Angelica dahurica, Citron, Platycodon grandiflorum and Mentha, steam distillation is used to extract volatile oils, and then the distilled water is further concentrated to fully utilize its water-soluble components. The distilled water is fully mixed during the preparation to maximize the effective components of the raw materials. The preparation method is accurate and cost-effective, suitable for large-scale production and use, and can reduce costs and improve benefits.

[0040] (5) The medicinal and edible composition of the present invention has a reasonable combination of raw materials, and has a therapeutic effect on patients with allergic rhinitis, especially children, from the perspectives of entering the lungs to drain, clearing away heat and detoxifying, improving spleen deficiency and enhancing immunity. The raw materials are synergistically matched, and the addition and subtraction of raw material components not only focus on rhinitis, but also strive to balance the body's immune system to balance the occurrence of rhinitis and achieve self-healing. The overall principle of traditional Chinese medicine treatment is reflected. Experimental verification shows that the composition has a definite therapeutic effect, and the clinical behavior indicators, blood IgE indicators and comprehensive indicators are all good. The scheme of the present invention provides a long-term, safe and non-toxic treatment scheme for patients with allergic rhinitis, which is especially suitable for children. DETAILED DESCRIPTION

[0041] The following describes the embodiments of the present invention through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. Obviously, the described embodiments are only part of the embodiments of the present invention, not all embodiments.

[0042] The present invention can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present invention. It should be noted that the following embodiments and features in the embodiments can be combined with each other without conflict. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0043] Example 1

[0044] A medicinal and edible granule preparation for allergic rhinitis, wherein the raw materials and weight proportions of the granule preparation are: 32 parts of houttuynia cordata, 25 parts of angelica dahurica, 25 parts of honeysuckle, 27 parts of coix seeds, 18 parts of polygonatum, 20 parts of astragalus, 10 parts of codonopsis pilosula, 12 parts of citron, 14 parts of ebony, 15 parts of platycodon, 13 parts of mint, 11 parts of liquorice, and 28 parts of honey;

[0045] The preparation method of the granules comprises the following steps:

[0046] 1) Weigh each raw material by weight, and coarsely grind the other Chinese medicinal ingredients with medicinal and edible properties except honey to obtain pre-treated raw materials;

[0047] 2) adding 6 times the weight of water to the pretreated Houttuynia cordata, honeysuckle, coix seed, polygonatum, astragalus, codonopsis, ebony, and liquorice, extracting at 60° C. for 20 minutes, filtering, separating the filtrate, adding 5 times the weight of water to the filter residue again, continuing to extract at 60° C. for 20 minutes, filtering to obtain a filtrate, and combining the two filtrates to obtain a pretreated product A;

[0048] Add 6 times the amount of water used in the raw materials to the pretreated angelica, bergamot, platycodon and mint, extract the volatile oil by steam distillation, collect the volatile oil B after condensation treatment by a multi-stage condensation system, continue to collect the distilled aqueous solution, and obtain the treated product C after filtration;

[0049] 3) The pre-treated product A and the treated product C are concentrated under reduced pressure, mixed with volatile oil B, further concentrated to a relative density of 1.25, and then further stirred and mixed with honey to obtain an active extract;

[0050] 4) Using the active extract obtained in step 3) as a raw material, a granule preparation for treating allergic rhinitis is prepared by using a granule processing technique.

[0051] Example 2

[0052] A medicinal and edible granule preparation for allergic rhinitis, wherein the raw materials and weight proportions of the granule preparation are: 25 parts of houttuynia cordata, 15 parts of angelica dahurica, 15 parts of honeysuckle, 20 parts of coix seeds, 8 parts of polygonatum, 10 parts of astragalus, 4 parts of codonopsis pilosula, 3 parts of bergamot, 6 parts of ebony, 6 parts of platycodon, 3 parts of mint, 3 parts of liquorice, and 10 parts of honey;

[0053] The preparation method of the granules comprises the following steps:

[0054] 1) Weigh each raw material by weight, and coarsely grind the other Chinese medicinal ingredients with medicinal and edible properties except honey to obtain pre-treated raw materials;

[0055] 2) adding 6 times the weight of water to the pretreated Houttuynia cordata, honeysuckle, coix seed, polygonatum, astragalus, codonopsis, ebony, and liquorice, extracting at 60° C. for 20 minutes, filtering, separating the filtrate, adding 5 times the weight of water to the filter residue again, continuing to extract at 60° C. for 20 minutes, filtering to obtain a filtrate, and combining the two filtrates to obtain a pretreated product A;

[0056] Add 6 times the amount of water used in the raw materials to the pretreated angelica, bergamot, platycodon and mint, extract the volatile oil by steam distillation, collect the volatile oil B after condensation treatment by a multi-stage condensation system, continue to collect the distilled aqueous solution, and obtain the treated product C after filtration;

[0057] 3) The pre-treated product A and the treated product C are concentrated under reduced pressure, mixed with volatile oil B, further concentrated to a relative density of 1.25, and then further stirred and mixed with honey to obtain an active extract;

[0058] 4) Using the active extract obtained in step 3) as a raw material, a granule preparation for treating allergic rhinitis is prepared by using a granule processing technique.

[0059] Comparative Example 1

[0060] No Houttuynia cordata is used in the raw materials. The amount of Houttuynia cordata is increased to the main Angelica dahurica and Coix seeds in equal amounts, i.e. 41 parts of Angelica dahurica and 43 parts of Coix seeds. The remaining raw material composition and preparation method are the same as in Example 1 to prepare a granular preparation.

[0061] Comparative Example 2

[0062] No coix seed is used in the raw materials, and the amount of coix seed is increased to the main Houttuynia cordata and Angelica dahurica in equal amounts, that is, 45.5 parts of Houttuynia cordata and 38.5 parts of Angelica dahurica. The remaining raw material composition and preparation method are the same as in Example 1 to prepare a granular preparation.

[0063] Experimental example

[0064] 1. Animal Experimental Research

[0065] (1) Animal modeling: An allergic rhinitis mouse model was constructed using an antigen-induced method. The specific operation included selecting 100 5-week-old female mice for modeling. During oral gavage, 25 μg of OVA was used as an antigen and 1 mg of aluminum hydroxide was used as an adjuvant. The mixture was suspended in 200 μl of PBS solution and the mice were immunized. Generally, multiple immunizations were required to produce specific IgE antibodies until allergic rhinitis was induced in the mice, and the modeling was considered successful.

[0066] (2) Treatment of experimental animals: The experimental animals were divided into five groups, namely, a positive control group (treated with loratadine), a blank control group, an example group (example 1) and a comparative example group (comparative examples 1 and 2), with 20 animals in each group. The obtained granules in the example group and the comparative example group were prepared into an 8% uniform aqueous solution as required, and each treatment group was treated by gavage on the experimental mice. The positive control group was treated with a dose of 3 mg / kg, while the example group and the comparative example group were gavaged with 0.6 ml of the aqueous solution of example 1 and comparative examples 1 and 2 per mouse each time, and the blank control group was gavaged with an equal amount of physiological saline per mouse each time; the above treatment groups were treated 3 times a day for 10 consecutive days, and then various indicators were measured.

[0067] (3) Experimental methods

[0068] During the measurement process, the behavior of mice in different treatment groups was first evaluated according to the behavioral scoring standard for allergic rhinitis mice, and then the animals were killed and blood was collected to evaluate the blood immunology-related indicator IgE for measurement.

[0069] The behavioral evaluation criteria for allergic rhinitis mice are shown in Table 1.

[0070] Table 1 Behavioral evaluation criteria for mice with allergic rhinitis

[0071]

[0072] The method for detecting the IgE content in mouse blood is to use a universal ELISA kit to measure the IgE content in the blood of each treatment group.

[0073] (4) Experimental results

[0074] Table 2 Comparison of behavioral and blood IgE levels in mice with allergic rhinitis in different treatment groups

[0075]

[0076] From Table 2, it can be seen that different treatment groups have a greater impact on the behavior and blood IgE content of mice with allergic rhinitis. During the treatment period, the sample of Example 1 of the present invention was used for treatment, and the overall treatment effect was close to that of the positive control group (loratadine), indicating that the composition of the present invention has excellent effects in the treatment of allergic rhinitis. Under the treatment conditions of Example 1 of the present invention, the behavioral performance and blood IgE content of mice were significantly different from those of the blank control group. Compared with Comparative Examples 1 and 2, its effect was significantly better than that of Comparative Examples 1 and 2, with better behavioral scores and better blood IgE content, indicating that the therapeutic effect of allergic rhinitis was deteriorated after the active ingredients Houttuynia cordata and Coix seeds were discarded respectively. Based on the above experimental results, it can be concluded that under the conditions of the embodiments of the present invention, the pharmaceutical composition has a good therapeutic effect on allergic rhinitis, which is close to the positive control group, and the adjustment and change of the raw materials will affect the therapeutic efficacy.

[0077] 2. Clinical application research

[0078] (1) Research subjects: A total of 80 patients with allergic rhinitis aged 8-16 years were selected for the study, half of whom were male and half were female. A 20-day clinical application study was conducted and the treatment effect of each group was recorded.

[0079] (2) Treatment method: The experiment was divided into a positive control group, Example 1 group, Comparative Example 1 group and Comparative Example 2 group. The patients took the drugs according to the prescribed dosage. The positive control group took one tablet of loratadine per day. The dosage of Example 1 group, Comparative Example 1 group and Comparative Example 2 groups was 3-9 grams per dose calculated according to the crude drug amount, 3 times a day.

[0080] (3) The following criteria should be used to evaluate the treatment effect:

[0081] The standard for marked effect is: symptoms such as runny nose, dizziness, nasal itching, sneezing, etc. are significantly relieved and basically disappear;

[0082] The criteria for effectiveness are: symptoms such as runny nose, dizziness, itchy nose, sneezing, etc. still exist, and the symptoms have been alleviated;

[0083] The criterion for ineffectiveness is that the symptoms are the same as before treatment or tend to be aggravated.

[0084] (4) Clinical trial results

[0085] The results of the clinical trials on patients are shown in Table 3.

[0086] Table 3 Comparison of clinical experimental results in different treatment groups

[0087]

[0088] It can be determined from the clinical experimental results in Table 3 that the total clinical effective rate of the product obtained under the conditions of the embodiment of the present invention reaches 90%, which is close to that of the positive control group of loratadine, and compared with the comparative example 1 and comparative example 2 groups, the total clinical effective rate is better under the conditions of the embodiment of the present invention. The above results can show that the compatibility relationship of the raw materials has a significant impact on the final therapeutic effect, the addition of Houttuynia cordata and Coix seed is indispensable to the compatibility of the entire prescription, and the overall therapeutic effect is definite and excellent.

[0089] The above description is only a specific implementation mode of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily conceived by a technician familiar with the technical field within the technical scope disclosed by the present invention should be covered within the protection scope of the present invention.

Claims

1. A medicine-food composition for allergic rhinitis, characterized in that The raw materials and weight portions in the composition are: 25-40 parts of houttuynia cordata, 15-40 parts of angelica dahurica, 15-40 parts of honeysuckle, 20-35 parts of coix seeds, 8-30 parts of polygonatum, 10-30 parts of astragalus, 4-20 parts of codonopsis pilosula, 3-18 parts of citron, 6-20 parts of ebony, 6-20 parts of platycodon, 3-25 parts of mint, 3-20 parts of liquorice and 10-40 parts of honey.

2. The edible-medicinal composition for allergic rhinitis according to claim 1, characterized in that: The raw materials and weight proportions in the composition are: 28-36 parts of houttuynia cordata, 20-30 parts of angelica dahurica, 20-30 parts of honeysuckle, 23-32 parts of coix seeds, 10-25 parts of polygonatum, 13-26 parts of astragalus, 8-16 parts of codonopsis pilosula, 5-15 parts of citron, 8-18 parts of ebony, 8-16 parts of platycodon, 5-20 parts of mint, 6-16 parts of liquorice and 20-35 parts of honey.

3. The medicine-food composition for allergic rhinitis according to claim 2, characterized in that: The raw materials and weight proportions in the composition are: 32 parts of houttuynia cordata, 25 parts of angelica dahurica, 25 parts of honeysuckle, 27 parts of coix seeds, 18 parts of polygonatum, 20 parts of astragalus, 10 parts of codonopsis pilosula, 12 parts of citron, 14 parts of ebony, 15 parts of platycodon, 13 parts of mint, 11 parts of liquorice and 28 parts of honey.

4. A preparation of a medicine-food combination for allergic rhinitis, characterized in that: The invention is prepared by using the composition according to any one of claims 1 to 3 as an active ingredient.

5. The preparation of a medicine-food combination for allergic rhinitis according to claim 4, characterized in that The preparation is in the form of tablets, granules, capsules or oral liquid.

6. A method for preparing a medicine-food combination for allergic rhinitis according to any one of claims 4 to 5, characterized in that: The steps include: 1) Weigh each raw material by weight, and coarsely grind the other Chinese medicinal ingredients with medicinal and edible properties except honey to obtain pre-treated raw materials; 2) adding 5-8 times the weight of the raw materials to the pretreated Houttuynia cordata, honeysuckle, coix seed, polygonatum, astragalus, codonopsis, ebony, and liquorice, extracting at 50-70° C. for 20 minutes, filtering, separating the filtrate, adding 4-6 times the weight of the raw materials to the filter residue again, continuing to extract at 50-70° C. for 20 minutes, filtering to obtain a filtrate, and combining the two filtrates to obtain a pretreated product A; Add 4-8 times the amount of water used as the raw materials to the pretreated angelica, bergamot, platycodon and mint, extract the volatile oil by steam distillation, collect the volatile oil B after condensation treatment by a multi-stage condensation system, continue to collect the distilled aqueous solution, and obtain the treated product C after filtration; 3) The pre-treated product A and the treated product C are concentrated under reduced pressure, mixed with volatile oil B, further concentrated, and further stirred and mixed with honey to obtain an active extract; 4) Using the active extract obtained in step 3) as a raw material, a preparation of a medicine-food combination for allergic rhinitis is prepared.

7. The method for preparing the medicine-food combination for allergic rhinitis according to claim 6, characterized in that: In the step 3), the mixture is further concentrated to a relative density of 1.2-1.

3.

8. The method for preparing the medicine-food combination for allergic rhinitis according to claim 6, characterized in that: The rotation speed of the stirring and mixing in step 3) is 500-800 rpm.

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