Astragalus mongholicus composite granular tea with anticoagulation function and preparation method of astragalus mongholicus composite granular tea

Abstract

The invention belongs to the technical field of health-care tea, and particularly relates to radix astragali composite granular tea with an anticoagulation function and a preparation method of the radix astragali composite granular tea. According to the invention, twelve medicinal and edible Chinese herbal medicines such as radix astragali, radix salviae miltiorrhizae, pseudo-ginseng and the like are used as raw materials, and the health-care radix astragali composite granular tea is prepared through the technological processes of decoction, concentration, granulation, drying and the like. The radix astragali composite granular tea can significantly prolong activated partial thrombin time (APTT), prothrombin time (PT) and thrombin time (TT) (P is less than 0.05), and can play an anticoagulant role through an endogenous blood coagulation pathway, an exogenous blood coagulation pathway and a pathway of inhibiting fibrinogen from being converted into fibrin. The tea can meet the pursuit of people for nutrition, health care, convenience and rapidness, does not lose the flavor characteristics of granular tea, has a certain anticoagulation function, develops the research direction of health tea, and is wide in market prospect.

Description

Technical Field

[0001] The invention belongs to the technical field of health tea drinks, and particularly relates to an astragalus composite granule tea with anticoagulant function and a preparation method thereof. Background Art

[0002] In the Chinese Pharmacopoeia, granules refer to "a dry granular preparation with a certain particle size formed by mixing raw materials with appropriate auxiliary materials". The advent of granular tea is inspired by Chinese medicine granules. Compared with the tea bags commonly available on the market, granular tea has the advantages of sufficient dissolution of nutrients and controllable dosage, sealed packaging, clean and not easy to be contaminated, and durable storage. It is also convenient to brew, easy to carry and store, and has the characteristics of unique nutrition, health care and flavor. Introducing medicinal and edible materials into people's daily diet to give full play to their pharmacological effects has become a popular trend. More and more health foods have appeared in the public's field of vision, and compound substitute teas have also catered to people's pursuit of health and wellness and have flooded into the market. But in fact, most of the substitute teas currently on the market are in the form of tea bags with various raw materials directly encapsulated in tea bags. The research on compound granular tea, especially tea drinks with multiple medicinal and edible raw materials, is not in-depth.

[0003] The ultimate goal of anticoagulation can be attributed to antithrombosis, and blood stasis syndrome is the initial understanding of thrombosis in traditional Chinese medicine. From the perspective of traditional Chinese medicine, the pathogenesis of blood stasis is mainly due to deficiency of yang qi, or stagnation of liver qi, or cold entering the meridians, or heat entering the blood, so anticoagulation treatment should be carried out by replenishing qi, promoting blood circulation, and removing blood stasis. Chinese medicines that promote blood circulation and remove blood stasis are widely used in anticoagulation treatment. Chinese medicine compound prescriptions are an important means of preventing and treating diseases in traditional Chinese medicine. They are the essence of traditional Chinese medicine in preventing and treating diseases. The pharmacological characteristics are the overall regulation of multiple components, multiple pathways, and multiple targets of pharmacological substances. A single drug cannot achieve the purpose of treating both the symptoms and the root causes. The combination of Chinese medicines can promote blood circulation and remove blood stasis in multiple targets, multiple angles, and in an all-round way.

[0004] Astragalus, first recorded in Shennong's Herbal Classic, is the root of Astragalus membranaceus or Astragalus mongolicus of the Leguminosae family. It is a good medicine for replenishing qi and promoting blood circulation and removing blood stasis. Modern pharmacological studies have shown that the active ingredients isolated from Astragalus mainly include polysaccharides, flavonoids and saponins, in addition to amino acids, alkaloids, choline, trace elements, folic acid, niacin, linolenic acid, linoleic acid, caffeic acid, betaine, riboflavin, coumarin, sterols, vitamins and other ingredients. These active ingredients give Astragalus a variety of effects such as anti-cardiovascular activity, anti-cancer, anti-viral, anti-diabetic, anti-inflammatory, antioxidant, blood pressure prevention and treatment, liver protection and immune regulation, which is one of the reasons why Astragalus has always been highly valued.

[0005] Salvia miltiorrhiza is a dicotyledonous plant of the Lamiaceae family. So far, more than 200 active ingredients have been extracted from it, mainly including tanshinone I, IIA, IIB, and dihydrotanshinone I. Salvia miltiorrhiza has significant effects in promoting blood circulation and removing blood stasis, cooling blood and reducing swelling, so it is widely used in the treatment of cardiovascular and cerebrovascular diseases. Phenolic acids and tanshinones in Salvia miltiorrhiza are the main active ingredients in the treatment of blood stasis syndrome. They can enhance anticoagulation and fibrinolytic ability, inhibit platelet activation and aggregation, and dilate blood vessels.

[0006] Panax notoginseng, a plant of the genus Panax in the Araliaceae family, is warm in nature, sweet and slightly bitter in taste. Its dried roots are often ground into powder and used as medicine. The active ingredients contained in Panax notoginseng can be roughly divided into: polysaccharides, flavonoids, saponins, amino acids, volatile oils, lipids and various trace elements, among which saponins and notoginseng are the main effective active ingredients. Among the saponin components, the total saponin content of Panax notoginseng is the highest, and it is the main blood-activating, blood-stasis-removing and anti-thrombotic component. Ginsenoside R1, notoginseng saponin R1 and notoginseng saponin R2 are the three main protopanaxatriol saponins in Panax notoginseng, which have potential cardiovascular protective activity; notoginseng, as a special amino acid, is the effective component of Panax notoginseng to exert its hemostatic effect.

[0007] Existing anticoagulant drugs containing Astragalus, Salvia miltiorrhiza and Panax notoginseng have complex components and contain many non-food Chinese medicines. Long-term use can easily cause damage to the liver and kidneys. Therefore, the development of a granular tea with anticoagulant function made from a compound of food and medicine materials can not only meet people's pursuit of nutritional health and convenience, but also provide a theoretical basis for the subsequent research and development of blood-activating and blood-stasis-removing health foods, and open up the research direction of health tea beverages. Summary of the invention

[0008] In order to solve the shortcomings of the existing technology, a health-care astragalus composite granular tea with anticoagulant function and a preparation method thereof are provided. Twelve kinds of Chinese herbal medicines with medicinal and edible properties, such as astragalus, salvia miltiorrhiza, and Panax notoginseng, are used as raw materials. A health-care astragalus composite granular tea with obvious anticoagulant effect is prepared through decoction, concentration, granulation, drying and other processes.

[0009] The technical solution adopted by the present invention is:

[0010] On the one hand, the present invention provides an astragalus composite granule tea with anticoagulant function, which contains the following components and their weight proportions respectively: 20-60 parts of astragalus, 20-50 parts of salvia miltiorrhiza, 10-30 parts of panax notoginseng, 5-25 parts of polygonatum, 5-30 parts of atractylodes, 5-30 parts of angelica, 5-25 parts of sophora japonica, 2-6 parts of red peony root, 1-5 parts of safflower, 10-30 parts of jujube, 1-8 parts of chuanxiong, and 3-10 parts of peach kernel.

[0011] Furthermore, the components and their weight proportions are respectively: 30-50 parts of Astragalus, 20-40 parts of Salvia miltiorrhiza, 15-25 parts of Panax notoginseng, 5-15 parts of Polygonatum, 10-20 parts of Atractylodes macrocephala, 10-20 parts of Angelica sinensis, 8-15 parts of Sophora japonica flower, 3-5 parts of Red Peony Root, 1-3 parts of Carthamus tinctorius, 10-20 parts of jujube, 2-5 parts of Ligusticum chuanxiong, and 3-6 parts of peach kernel.

[0012] Furthermore, the components and their weight proportions are respectively: 36-40 parts of Astragalus, 26-30 parts of Salvia miltiorrhiza, 16-18 parts of Panax notoginseng, 8-10 parts of Polygonatum, 10-12 parts of Atractylodes macrocephala, 10-12 parts of Angelica sinensis, 8-10 parts of Sophora japonica flower, 3-5 parts of Red Peony Root, 1-2 parts of Carthamus tinctorius, 10-14 parts of jujube, 2-3 parts of Ligusticum chuanxiong, and 3-5 parts of peach kernel.

[0013] Another aspect of the present invention provides a method for preparing an astragalus composite granule tea having an anticoagulant function, comprising the following steps:

[0014] (1) Weighing: Weighing the medicinal materials according to the components and weight proportions contained in the astragalus composite granular tea;

[0015] (2) Soaking: soak all the weighed medicinal materials except Panax notoginseng with water at a material-liquid ratio of 1:8 to 1:14 for 20 to 60 minutes to obtain soaked medicinal materials and medicinal liquid;

[0016] (3) decoction and concentration: boil the soaked medicinal materials and medicinal solution in step (2) over high heat, then slowly decoct over low heat, decoct for 40 to 100 minutes, filter, add 6 to 12 times the amount of water and decoct for 40 minutes, repeat the decoction 2 to 4 times, and combine all the filtrates; place the filtrate on a rotary evaporator and concentrate under reduced pressure, add the weighed Panax notoginseng when the density is 1.01 to 1.05 g / mL, and continue to concentrate until the density is 1.18 to 1.23 g / mL of extract;

[0017] (4) Granulation: Mix the extract and the excipient in a mass ratio of 1:2 to 1:4, extrude and screen the granules, and dry them with hot air at 40 to 80° C. for 30 to 100 min to obtain dry astragalus composite granules;

[0018] (5) Whole particles: First, assemble the No. 1 sieve and the No. 5 sieve up and down, pour the dried Astragalus composite granules onto the assembled No. 1 sieve, shake the sieve horizontally, and tap it continuously until the No. 1 sieve and the No. 5 sieve no longer leak particles downward, retain the particles between the No. 1 sieve and the No. 5 sieve, and bag them to obtain the Astragalus composite granule tea.

[0019] Furthermore, the excipient is one or more of lactose, xylitol, microcrystalline cellulose, β-cyclodextrin, erythritol, xanthan gum, and sodium alginate. More preferably, the excipient is a 1:1 mixture of lactose and xylitol.

[0020] Furthermore, the No. 1 sieve is 10 mesh and the No. 5 sieve is 80 mesh.

[0021] Sophora japonica flower, bitter, slightly cold. Human liver and large intestine meridians. Cool blood and stop bleeding, clear liver and purge fire. Used for blood in stool, hemorrhoids, blood, metrorrhagia, vomiting blood, blood, liver heat and red eyes, headache and dizziness, carbuncle, waxberry sore, intestinal wind and constipation, and prevention of stroke.

[0022] Chuanxiong, spicy, warm in nature. Liver, gallbladder, pericardium meridian. It can promote qi and relieve depression, dispel wind and dampness, activate blood circulation, relieve pain. It is used for irregular menstruation, amenorrhea, dysmenorrhea, postpartum blood stasis, fatigue, abdominal pain, chest and rib pain, coronary heart disease, angina pectoris, headache, rheumatism, cold, tumor swelling and pain, limb numbness, and traumatic injuries.

[0023] Polygonatum sibiricum, sweet in taste, neutral in nature, enters the spleen, lung, and kidney meridians. It nourishes the spleen and stomach, moistens the heart and lungs, produces fluid and nourishes yin, replenishes the middle and replenishes qi, and strengthens the tendons and bones. It is used for spleen and stomach weakness, dry cough due to lung deficiency, internal heat and thirst, lack of essence and blood, dry mouth and poor appetite, soreness of waist and knees, dizziness and palpitations, hypertension, arteriosclerosis, anemia, rheumatism, weakness after illness, fatigue, etc.

[0024] Atractylodes macrocephala, bitter and sweet in taste, warm in nature, enters the spleen and stomach meridians. It strengthens the spleen and replenishes qi, dries dampness and promotes diuresis, stops sweating, and stabilizes pregnancy. It is used for spleen and stomach weakness, fatigue, sallow complexion, poor appetite and abdominal distension, loose stools, water retention, urination difficulties, edema, limb soreness, qi deficiency and spontaneous sweating, restless fetal movement, indigestion, chronic diarrhea, etc.

[0025] Angelica sinensis, sweet, spicy, warm in nature. It is used in the liver, heart, and spleen meridians. It nourishes the liver and replenishes blood, regulates menstruation, regulates blood circulation, and lubricates the intestines to relieve constipation. It is used for blood deficiency and sallow complexion, dizziness and palpitations; irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain during menstruation, amenorrhea, metrorrhagia, various symptoms of pregnancy, headache due to blood deficiency, abdominal pain due to deficiency and cold, constipation due to dry intestines, rheumatic arthralgia, heaviness after dysentery, uterine prolapse, traumatic injury, carbuncle sore. Wine Angelica sinensis promotes blood circulation and unblocks menstruation. It is used for amenorrhea and dysmenorrhea, rheumatic arthralgia, and traumatic injury.

[0026] Red peony root, bitter in taste, cold in nature. In the liver meridian. Clears heat and cools blood, dissipates and relieves pain. Used for fever and toxicity, vomiting blood, red and swollen eyes, liver depression, hypochondriac pain, amenorrhea, dysmenorrhea, abdominal pain, fever, red tongue, macules and hemorrhages, dysentery, traumatic injury, carbuncle, swelling and ulcer.

[0027] Safflower, pungent in taste, warm in nature. Heart and liver meridians. It promotes blood circulation and menstruation, dissipates and relieves pain. It is used for amenorrhea, dysmenorrhea, lochia, postpartum blood, abdominal pain caused by blood stasis, fatigue, lumps, injuries from falls, chest and spleen pain, hypochondria, epigastric pain, and sores and swelling.

[0028] Jujube, sweet, warm, non-toxic. It replenishes the middle qi, nourishes blood and calms the mind. It is used for spleen deficiency, poor appetite, fatigue, loose stools, and irritability in women. It prevents transfusion reactions, reduces serum alanine aminotransferase, fights tumors, resists oxidation, lowers blood pressure and cholesterol, protects the liver, improves immunity, prevents and treats cerebral ischemia, is anti-allergic, prevents and treats cardiovascular diseases, and prevents and treats osteoporosis and anemia.

[0029] Peach kernel, bitter and sweet, neutral in nature. Heart, liver, large intestine meridian. Promotes blood circulation and removes blood stasis, moistens the intestines and relieves constipation. Used for amenorrhea, dysmenorrhea, blood from traumatic injury, intestinal constipation, blood stasis and swelling, lung abscess, intestinal abscess, abdominal pain due to blood stasis after childbirth, blood accumulation due to febrile disease, rheumatism, and malaria.

[0030] The astragalus composite granule tea of ​​the present invention uses astragalus, salvia miltiorrhiza and Panax notoginseng as main drugs. In order to promote the effect of the main drugs, polygonatum, sophora flower, Chuanxiong, atractylodes macrocephala, angelica, red peony root, safflower, peach kernel and jujube are supplemented to play a synergistic role with the main drugs. The astragalus is used to invigorate qi and replenish qi, salvia miltiorrhiza can promote blood circulation and remove blood stasis, cool blood and reduce swelling, and Panax notoginseng can promote blood circulation and stop bleeding in a two-way manner. Polygonatum is used to invigorate qi, sophora flower cools blood, Chuanxiong promotes qi and promotes blood circulation, atractylodes macrocephala strengthens the spleen and replenishes qi, angelica promotes blood circulation and replenishes blood, red peony root clears heat and cools blood, safflower and peach kernel promote blood circulation and removes blood stasis, and jujube can invigorate qi and nourish blood. The twelve medicinal and edible materials are compounded and synergistically acted, so that the prepared astragalus composite granule tea has obvious anticoagulant effect. Since the dosage is small and all of them are medicinal and edible drugs, there is no side effect on human body.

[0031] The advantages and positive effects of the present invention are:

[0032] 1. The astragalus composite granular tea of ​​the present invention is compounded into a new type of granular tea with twelve medicinal and edible medicinal materials such as astragalus, salvia miltiorrhiza, and Panax notoginseng, which has obvious anticoagulant effect. Since the dosage is small and they are all medicinal and edible drugs, they have no side effects on the human body. It provides a theoretical basis for the subsequent research and development of health-care foods for promoting blood circulation and removing blood stasis, which can well cater to market trends and meet consumer needs.

[0033] 2. During the preparation process of the present invention, one, two or three of lactose, xylitol, microcrystalline cellulose, β-cyclodextrin, erythritol, xanthan gum, sodium alginate and the like are added to the extract, which plays the role of shaping, masking taste, preserving and moisture-proofing, can significantly reduce the unpleasant odor of Chinese herbal medicines, and improve the flavor and taste of the Astragalus composite granule tea. DETAILED DESCRIPTION

[0034] The present invention will be further described in detail below in conjunction with specific implementation examples. It should be understood that the following examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0035] Example 1

[0036] A method for preparing astragalus composite granule tea with anticoagulant function comprises the following steps:

[0037] (1) Weighing: Weigh 36 g of Astragalus, 26 g of Salvia miltiorrhiza, 18 g of Panax notoginseng, 9 g of Polygonatum, 10 g of Atractylodes macrocephala, 10 g of Angelica sinensis, 9 g of Sophora japonica, 3 g of Red Peony Root, 2 g of Carthamus tinctorius, 14 g of Jujube, 2.5 g of Ligusticum chuanxiong, and 4.5 g of Prunus persica;

[0038] (2) Soaking: All the weighed medicinal materials except Panax notoginseng were soaked in water at a material-liquid ratio of 1:13 for 40 minutes to obtain soaked medicinal materials and medicinal liquid;

[0039] (3) Decoction and concentration: Boil the soaked medicinal materials and medicinal liquid in step (2) over high heat, then simmer over low heat, decoct for 60 minutes, filter, then add 8 times the amount of water and decoct for 40 minutes, repeat the decoction 3 times, and combine all the filtrates. Place the filtrate in a rotary evaporator and concentrate under reduced pressure. When the concentrated density is 1.01 g / mL, add the weighed Panax notoginseng and continue to concentrate to an extract with a density of 1.18 to 1.23 g / mL;

[0040] (4) Granulation: Lactose and xylitol were mixed as excipients in a ratio of 1:1, and the extract and excipient were mixed in a mass ratio of 1:2.5, extruded and sieved to granulate, and hot-air dried at 60° C. for 40 min to obtain dry astragalus composite granules;

[0041] (5) Whole particles: First, assemble the No. 1 sieve (10 mesh) and the No. 5 sieve (80 mesh) up and down, pour the dried Astragalus composite granules onto the assembled No. 1 sieve, shake the sieve horizontally, and tap it continuously until the No. 1 and No. 5 sieves no longer leak particles downward, retain the particles between the No. 1 and No. 5 sieves, and bag them to obtain the Astragalus composite granule tea.

[0042] Example 2

[0043] The only difference from Example 1 is that 38g of Astragalus, 30g of Salvia miltiorrhiza, 16g of Panax notoginseng, 8g of Polygonatum, 11g of Atractylodes, 11g of Angelica sinensis, 9g of Sophora japonica, 4g of Red Peony Root, 2g of Carthamus tinctorius, 10g of jujube, 2g of Ligusticum chuanxiong, and 3g of peach kernel are weighed.

[0044] Example 3

[0045] The only difference from Example 1 is that 40g of Astragalus, 28g of Salvia miltiorrhiza, 18g of Panax notoginseng, 10g of Polygonatum, 10g of Atractylodes macrocephala, 10g of Angelica sinensis, 8g of Sophora japonica, 3g of Red Peony Root, 1g of Carthamus tinctorius, 10g of jujube, 2.5g of Chuanxiong, and 3.5g of peach kernel are weighed.

[0046] Comparative Example 1 (without using Sophora japonica)

[0047] The only difference from Example 1 is that 36 g of Astragalus, 26 g of Salvia miltiorrhiza, 18 g of Panax notoginseng, 9 g of Polygonatum, 10 g of Atractylodes macrocephala, 10 g of Angelica sinensis, 3 g of Red Peony Root, 2 g of Carthamus tinctorius, 14 g of Jujube, 2.5 g of Chuanxiong, and 4.5 g of Peach Kernel were weighed;

[0048] Comparative Example 2 (without using Chuanxiong)

[0049] The only difference from Example 1 is that 36g of Astragalus, 26g of Salvia miltiorrhiza, 18g of Panax notoginseng, 9g of Polygonatum, 10g of Atractylodes, 10g of Angelica sinensis, 9g of Sophora japonica, 3g of Red Peony Root, 2g of Carthamus tinctorius, 14g of Jujube, and 4.5g of Peach Kernel were weighed.

[0050] Comparative Example 3 (without using Sophora japonica and Chuanxiong)

[0051] The only difference from Example 1 is that 36 g of Astragalus, 26 g of Salvia miltiorrhiza, 18 g of Panax notoginseng, 9 g of Polygonatum, 10 g of Atractylodes macrocephala, 10 g of Angelica sinensis, 3 g of Red Peony Root, 2 g of Carthamus tinctorius, 14 g of Jujube, and 4.5 g of Peach Kernel were weighed.

[0052] The results of the determination of the polysaccharide, flavonoid and saponin contents in the Astragalus composite granular tea prepared in Example 1 are shown in Table 1. As can be seen from the results in Table 1, the polysaccharide with the highest content of active ingredients in the Astragalus composite granular tea prepared in Example 1 is followed by the content of active ingredients such as flavonoids and saponins, indicating that Sophora japonica and Chuanxiong can synergistically promote the content of active substances such as polysaccharides, flavonoids and saponins in the granular tea, that is, the data of Comparative Examples 1 to 2 in the experimental data are worse than those of Example 1, and Comparative Example 3 is worse than Comparative Examples 1 to 2. All data results are expressed as mean ± standard deviation.

[0053] Table 1 Results of determination of ingredients of Astragalus composite granular tea prepared in Example 1 and Comparative Examples 1 to 3

[0054]

[0055] Results of the index inspection of Astragalus compound granule tea

[0056] According to the inspection indicators for granules in General Chapter 0104 of Part IV of the 2020 edition of the Pharmacopoeia of the People's Republic of China. Due to the solubility index, granules containing Chinese medicine raw powder are not subject to solubility inspection, so appropriate indicators are selected for research, and the results are shown in Table 2.

[0057] Table 2 Test results of the indexes of the astragalus composite granular tea prepared in Example 1 and Comparative Examples 1 to 3

[0058]

[0059] Anticoagulation function test

[0060] The three coagulation test results of Astragalus, Salvia miltiorrhiza, Panax notoginseng and the Astragalus composite granule tea prepared in Example 1 and Comparative Examples 1 to 3 were measured respectively.

[0061] Source of blood: Blood was collected from healthy volunteers at Zhumadian Central Hospital in Henan Province.

[0062] Preparation of platelet-poor plasma: draw fresh blood into a blue blood collection tube containing 3.8% sodium citrate at a volume ratio of 9:1. Mix well, centrifuge at 3500r / min for 10min, collect the supernatant to obtain platelet-poor plasma (PPP), and set aside. The experiment must be completed within 3 hours.

[0063] Preparation of sample solution: Grind the Astragalus composite granules prepared in Example 1 into powder, crush the Astragalus, Salvia miltiorrhiza, and Panax notoginseng medicinal materials through a 60-mesh sieve, use Panax notoginseng powder directly, and dissolve them in 0.9% physiological saline according to a solid-liquid ratio of 1:5, ultrasonicate for 40 minutes, centrifuge at 4000r / min for 15 minutes, take the supernatant, and store at 4°C. The Astragalus composite granule tea sample to be tested in Example 1 prepared according to the above solid-liquid ratio is named "Astragalus composite granule tea-1", and the sample obtained by 2-fold dilution on this basis is named "Astragalus composite granule tea-2". The comparative examples 1 to 3 prepared according to the above solid-liquid ratio are respectively Astragalus composite granule tea-3, Astragalus composite granule tea-4, and Astragalus composite granule tea-5.

[0064] Low molecular weight enoxaparin sodium injection (0.6 mL: 6000 Axa IU) was diluted with normal saline to 5 IU / mL as a positive control group, and 0.9% normal saline was used as a blank control group.

[0065] Platelet-poor plasma was mixed with the sample solution in a ratio of 1:2 and tested with an automatic coagulation instrument. The inhibitory effects of Astragalus, Salvia miltiorrhiza, and Astragalus composite granule tea on ADP-induced coagulation mechanism were studied by measuring activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT).

[0066] Regarding the data in Table 3, compared with the normal saline in the blank control group, Astragalus, Salvia miltiorrhiza, Panax notoginseng and granular tea of ​​a certain concentration can significantly prolong APTT, PT and TT (P < 0.05). As can be seen from the table, the APTT, PT and TT extension time of Astragalus, Salvia miltiorrhiza and Panax notoginseng alone are lower than the data in Example 1; while the APTT, PT and TT extension time of Astragalus composite granular tea-3 (without Sophora japonica) and Astragalus composite granular tea-4 (without Chuanxiong) are slightly improved compared with Astragalus composite granular tea-5 (neither Sophora japonica nor Chuanxiong are used), indicating that Sophora japonica and Chuanxiong also have effects alone, but the effects are not obvious; Astragalus composite granular tea-3, Astragalus composite granular tea-4 and Astragalus composite granular tea-5 are all less effective than Astragalus composite granular tea-1 and Astragalus composite granular tea-2, indicating that Sophora japonica and Chuanxiong have a synergistic effect, which can synergistically improve the anticoagulant function of Astragalus composite granular tea, that is, the APTT, PT and TT extension time are greatly improved, and the mechanism is to exert anticoagulant effects through three pathways: intrinsic coagulation pathway, exogenous coagulation pathway and inhibition of fibrinogen conversion to fibrin.

[0067] Table 3 Three coagulation test results of Astragalus, Salvia miltiorrhiza, Panax notoginseng and Astragalus composite granule tea prepared in Example 1 and Comparative Examples 1 to 3

[0068]

[0069]

[0070] Note: a, b, c, d, e represent differences P < 0.05.

[0071] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A compound astragalus granule tea with anticoagulant function, It is characterized in that The components and their weight proportions are respectively: 20-60 parts of astragalus, 20-50 parts of salvia miltiorrhiza, 10-30 parts of panax notoginseng, 5-25 parts of polygonatum, 5-30 parts of atractylodes, 5-30 parts of angelica, 5-25 parts of sophora japonica flower, 2-6 parts of red peony root, 1-5 parts of safflower, 10-30 parts of jujube, 1-8 parts of ligusticum chuanxiong and 3-10 parts of peach kernel.

2. The astragalus composite granule tea according to claim 1, It is characterized in that The components and their weight proportions are respectively: 30-50 parts of astragalus, 20-40 parts of salvia miltiorrhiza, 15-25 parts of panax notoginseng, 5-15 parts of polygonatum, 10-20 parts of atractylodes, 10-20 parts of angelica, 8-15 parts of sophora japonica flower, 3-5 parts of red peony root, 1-3 parts of safflower, 10-20 parts of jujube, 2-5 parts of ligusticum chuanxiong and 3-6 parts of peach kernel.

3. The astragalus composite granule tea according to claim 2, It is characterized in that The components and their weight proportions are respectively: 36-40 parts of astragalus, 26-30 parts of salvia miltiorrhiza, 16-18 parts of panax notoginseng, 8-10 parts of polygonatum, 10-12 parts of atractylodes, 10-12 parts of angelica, 8-10 parts of sophora japonica flower, 3-5 parts of red peony root, 1-2 parts of safflower, 10-14 parts of jujube, 2-3 parts of ligusticum chuanxiong and 3-5 parts of peach kernel.

4. The method for preparing the astragalus composite granule tea according to any one of claims 1 to 3, It is characterized in that The following steps are involved: (1) Weighing: Weighing the medicinal materials according to the components and weight proportions contained in the astragalus composite granular tea; (2) Soaking: soaking all weighed medicinal materials except Panax notoginseng in water at a material-liquid ratio of 1:8 to 1:14 for 20 to 60 minutes to obtain soaked medicinal materials and medicinal liquid; (3) decoction and concentration: boil the soaked medicinal materials and medicinal liquid in step (2) over high heat, then slowly decoct over low heat, decoct for 40 to 100 minutes, filter, then add 6 to 12 times the amount of water and decoct for 30 to 40 minutes, repeat the decoction 2 to 4 times, and combine all the filtrates; place the filtrate on a rotary evaporator and concentrate under reduced pressure, add the weighed Panax notoginseng when the density is 1.01 to 1.05 g / mL, and continue to concentrate until the density of the extract is 1.18 to 1.23 g / mL; (4) Granulation: Mix the extract and excipient in a mass ratio of 1:2 to 1:4, extrude and sieve to granulate, and dry with hot air for 30 to 100 minutes to obtain dry astragalus composite granules; (5) Granulation: Assemble the No. 1 sieve and the No. 5 sieve up and down, pour the dried Astragalus composite granules onto the assembled No. 1 sieve, shake the sieve horizontally, and tap it continuously until the No. 1 sieve and the No. 5 sieve no longer leak particles downward, retain the particles between the No. 1 sieve and the No. 5 sieve, and bag them to obtain the Astragalus composite granules.

5. The preparation method according to claim 4, It is characterized in that The excipient is one or more of lactose, xylitol, microcrystalline cellulose, beta-cyclodextrin, erythritol, xanthan gum and sodium alginate.

6. The preparation method according to claim 4, It is characterized in that The No. 1 sieve has 10 meshes, and the No. 5 sieve has 80 meshes.

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