Tanvermectin drops as well as preparation method and application thereof

Abstract

The invention provides tenvermectin drops as well as a preparation method and application thereof, and belongs to the technical field of pet medicine, and the tenvermectin drops comprise the following components in percentage by mass: 0.1-3.0% of tenvermectin, 5.0-30% of unsaturated fatty acid and 65.0-94.9% of a carrier. According to the tenvermectin drop disclosed by the invention, tenvermectin is stored in sebaceous glands of an organism through diffusion under the action of the carrier and is gradually released from the sebaceous glands, so that a slow-release effect is achieved; on one hand, parasites can be controlled for a long time, on the other hand, the health problem of fur can be solved, and the fur health problem caused by parasites is truly and comprehensively solved; in addition, the drop provided by the invention is convenient to use, and can effectively solve the stress reaction of the injection to animals.

Description

Technical Field

[0001] The invention belongs to the technical field of pet medicine, and in particular relates to a tianweimectin drop, a preparation method and an application thereof. Background Art

[0002] In recent years, the breeding industry of special fur animals in China's coastal areas has flourished, and the number of species has increased (fox, mink, raccoon dog, rex rabbit, etc.). With the continuous increase in the number of breeding and stocking density, the types of fur animal diseases have gradually increased, especially parasites that cause unhealthy fur of fur animals, causing serious losses to breeders.

[0003] In addition, one of the goals of raising pet dogs and cats is to have a healthy and beautiful appearance. The most visible appearance feature is the condition of their fur. Spring is the peak season for skin diseases in pet dogs and cats. Dogs and cats with skin diseases show symptoms such as hair loss, itching, papules, and ulcers. The causes are often fungi, scabies, demodex mites, lice, fleas, tick bites, bacterial infections, allergies, endocrine disorders, and other factors.

[0004] Tianweimectin is a new type of 16-membered macrolide insecticidal antibiotic obtained from a genetically engineered strain constructed by combinatorial biosynthesis. However, if it is used directly, there are problems such as poor efficacy and inability to be used for a long time.

[0005] In view of this, it is necessary to provide a kind of tianweimectin drops to solve the above-mentioned technical problems. Summary of the invention

[0006] In order to solve the above problems existing in the prior art, the present invention provides a tianweimectin drop and a preparation method and application thereof. The tianweimectin drop diffuses through the action of a carrier, stores tianweimectin in the sebaceous glands of the body, and gradually releases it from the sebaceous glands to achieve a sustained release effect.

[0007] An object of the present invention is to provide a kind of tianweimectin drops.

[0008] The tianweimectin drops comprise tianweimectin, polyunsaturated fatty acids and a carrier.

[0009] In some embodiments, the tianweimectin drops include the following components, measured by mass percentage: 0.1-3.0% tianweimectin, 5.0-30% unsaturated fatty acid and 65.0-94.9% carrier.

[0010] In some embodiments, the carrier is selected from one or more mixtures of butylene glycol, dimethylacetamide, dimethylformamide, dipropylene glycol monobutyl ether, ethanol, isopropanol, ethoxydiglycol, ethylene glycol monoethyl ether, monoethylacetamide, dipropylene glycol monomethyl ether, liquid polyoxyethylene glycol, and propylene glycol.

[0011] In some embodiments, the carrier is ethoxydiglycol.

[0012] In some embodiments, the unsaturated fatty acid is selected from one or more mixtures of fish oil, hemp oil, neem seed oil, sunflower oil, eicosapentaenoic acid, docosahexaenoic acid, rapeseed oil, walnut oil and phoenix grass oil.

[0013] In some embodiments, the unsaturated fatty acids consist of hemp oil and neem seed oil in a volume ratio of 1:2-2:1.

[0014] Among them, hemp oil has hair care and other benefits, while neem seed oil has antibacterial and other benefits.

[0015] Another object of the present invention is to provide the use of any of the above-mentioned tianweimectin drops in the preparation of a medicament for treating animal fur infection.

[0016] The specific method of the above application is as follows: the said tianweimectin drops or the said medicine are applied to at least one specific position on the animal's fur (with infection or fur health problems), and the said drops have a carrier as a solvent, tianweimectin and at least one essential oil complex. The effective components of the said drops are diffused by the action of the said carrier, and then stored in the sebaceous glands of the animal. Finally, the effective components are gradually released from the sebaceous glands to achieve the purpose of treatment.

[0017] In some embodiments, the animal is selected from one or more of a fox, a mink, a raccoon dog, a rex rabbit, a cat, and a dog.

[0018] In some embodiments, the animal's coat infection is caused by a parasite.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] In the tianweimectin drops of the present invention, tianweimectin is diffused through the action of the carrier, stored in the sebaceous glands of the body, and gradually released from the sebaceous glands to achieve a sustained release effect; on the one hand, parasites can be controlled long-term, and on the other hand, the health problems of fur can be solved, truly and comprehensively solving the health problems of fur caused by parasites; in addition, the drops of the present invention are easy to use and can effectively solve the stress response of injections to animals. DETAILED DESCRIPTION

[0021] The technical solution of the present invention will be clearly and completely described below in conjunction with specific embodiments. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0022] The experimental methods without specific conditions in the examples are usually carried out according to conventional conditions and conditions described in the manual, or according to conditions recommended by the manufacturer. The general equipment, materials, reagents, etc. used are all available from commercial channels unless otherwise specified.

[0023] The tianweimectin used in the present invention is prepared by referring to the method in Chinese patent document CN 110540556B.

[0024] Example 1 Preparation of Tianweimectin Drops 1

[0025] 0.1 g of tianweimectin was added to 67.9 g of ethoxydiglycol, and after stirring and dissolving completely, 15 g of hemp oil, 15 g of neem seed oil and 2 g of tocopherol acetate were added respectively, and the mixture was evenly mixed to obtain tianweimectin drops 1.

[0026] Example 2 Preparation of Tianweimectin Drops II

[0027] 0.5 g of tianweimectin was added to 62.5 g of ethoxydiglycol, and after stirring and dissolving completely, 20 g of hemp oil, 15 g of neem seed oil and 2 g of tocopherol acetate were added respectively, and the mixture was evenly mixed to obtain tianweimectin drops II.

[0028] Example 3 Preparation of Tianweimectin Drops III

[0029] Add 3.0 g of tianweimectin to 80 g of ethoxydiglycol, stir and dissolve completely, then add 10 g of hemp oil, 5 g of neem seed oil and 2 g of tocopherol acetate respectively, mix well to obtain tianweimectin drops III.

[0030] Example 4 Preparation of Tianweimectin Drops IV

[0031] Add 1.0 g of tianweimectin to 67 g of ethoxydiglycol, stir and dissolve completely, then add 10 g of hemp oil, 20 g of neem seed oil and 2 g of tocopherol acetate respectively, mix well to obtain tianweimectin drops IV.

[0032] Example 5 Preparation of Tianweimectin Drops 5

[0033] Add 0.5 g of tianweimectin to 67.5 g of ethoxydiglycol, stir and dissolve completely, then add 5 g of fish oil, 5 g of hemp oil, 10 g of neem seed oil, 5 g of sunflower oil, 5 g of phoenix grass oil and 2 g of tocopherol acetate respectively, mix well to obtain tianweimectin drops five.

[0034] Example 6 Preparation of Tianweimectin Drops VI

[0035] Add 0.5 g of tianweimectin to 67.5 g of ethoxydiglycol, stir and dissolve completely, then add 10 g of hemp oil, 10 g of neem seed oil, 5 g of eicosapentaenoic acid, 5 g of docosahexaenoic acid and 2 g of tocopherol acetate respectively, mix well to obtain tianweimectin drops VI.

[0036] Example 7 Preparation of Tianweimectin Injection

[0037] Dissolve 1 g of tianweimectin in 9 ml of dimethylformamide, add into 90 ml of propylene glycol, stir evenly, and filter aseptically to obtain 1% tianweimectin injection.

[0038] Example 8 Effect of Tianweimectin Preparation on Fox Fur

[0039] 1) Effects of Tianweimectin injection on fox fur

[0040] The effect of the tianweimectin injection prepared in Example 7 on sick foxes was observed by intramuscular injection at 0.3 ml / kg.

[0041] The results of the clinical trial after 14 days of administration showed that Tianweimectin injection had a 100% deworming rate for fox mites, and no recurrence occurred within a few months after the administration until the animals were marketed. Seven days after administration, the skin crusted and the symptoms of skin congestion at the hair loss site disappeared. After 14 days, a small amount of hair grew at the hair loss site, and after 21 days, a large amount of hair grew at the hair loss site.

[0042] 2) Effects of Tianweimectin Drops on Fox Fur

[0043] The hair between the back and shoulders of the fox was parted, and then the tianweimectin drops prepared in Example 4 were dropped on the skin of the fox at an amount of 0.5 ml / kg, and the effect on the diseased fox was observed.

[0044] The results of the clinical trial after 14 days of administration showed that Tianweimectin drops had a 100% deworming effect on fox mites, and there was no recurrence within a few months after the medication until the animals were marketed. Seven days after the administration, the skin crusted and the congestion symptoms at the hair loss site disappeared. After 14 days, a large amount of hair grew at the hair loss site. After 21 days, the hair completely recovered to a healthy state and was shiny and lustrous.

[0045] It can be seen from the above results that, compared with the tianweimectin injection, the drops prepared by mixing tianweimectin with unsaturated fatty acids and a carrier in the present invention have better therapeutic effects.

[0046] The above embodiments are only specific implementation methods of the present invention, which are used to illustrate the technical solutions of the present invention rather than to limit them. The protection scope of the present invention is not limited thereto. Although the present invention has been described in detail with reference to the aforementioned embodiments, ordinary technicians in the field should understand that any technician familiar with the technical field can still modify the technical solutions recorded in the aforementioned embodiments within the technical scope disclosed by the present invention, or can easily think of changes, or make equivalent replacements for some of the technical features therein; and these modifications, changes or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present invention, and should all be covered within the protection scope of the present invention.

Claims

1. A tianweimectin drops, characterized in that, The invention comprises the following components by mass percentage: 0.1-3.0% of tianweimectin, 5.0-30% of unsaturated fatty acid and 65.0-94.9% of carrier.

2. The tianweimectin drops according to claim 1, characterized in that The carrier is selected from one or more mixtures of butanediol, dimethylacetamide, dimethylformamide, dipropylene glycol monobutyl ether, ethanol, isopropanol, ethoxydiglycol, ethylene glycol monoethyl ether, monoethylacetamide, dipropylene glycol monomethyl ether, liquid polyoxyethylene glycol, and propylene glycol.

3. The tianweimectin drops according to claim 2, characterized in that The carrier is ethoxydiglycol.

4. The tianweimectin drops according to claim 1, characterized in that The unsaturated fatty acid is selected from one or more of fish oil, hemp oil, neem seed oil, sunflower oil, eicosapentaenoic acid, docosahexaenoic acid, rapeseed oil, walnut oil and phoenix grass oil.

5. The tianweimectin drops according to claim 4, characterized in that The unsaturated fatty acid consists of hemp oil and neem seed oil in a volume ratio of 1:2-2:

1.

6. Use of the tianweimectin drops according to any one of claims 1 to 5 in the preparation of a medicament for treating animal fur infection.

7. The use according to claim 6, characterized in that: The animal is selected from one or more of fox, mink, raccoon dog, rex rabbit, cat and dog.

8. The use according to claim 7, characterized in that: The animal's fur infection is caused by parasites.