High-precision high-altitude environment simulation animal experiment module system and method

Abstract

The invention relates to the technical field of experimental animal research equipment, in particular to a high-precision high-altitude environment simulation animal experiment module system and method. The system comprises an environment control air chamber, an intelligent adjusting system, an animal physiological parameter real-time monitoring system, an automatic feeding system, an automatic sample collecting system, a data processing center and a monitoring system. According to the invention, a plurality of environmental factors such as air pressure, oxygen content, temperature, humidity, UV radiation and the like can be simulated at the same time, and experimental conditions closer to a real high-altitude environment are provided for research; a modular design is adopted, the scale and functions of the system are allowed to be flexibly adjusted according to research requirements, and the system adapts to different types of high-altitude related researches; and the quality and the efficiency of related research of the high-altitude environment can be remarkably improved.

Description

Technical Field

[0001] The present invention relates to the technical field of experimental animal research equipment, and in particular to a high-precision high-altitude environment simulation animal experimental cabin system and method. Background Art

[0002] With the increase of high-altitude area development and related medical research, the study of physiological responses in high-altitude environment has become increasingly important. However, animal experiments in actual high-altitude environments face many challenges, such as the difficulty in accurately controlling environmental conditions, high experimental costs, and high safety risks. Therefore, it is of great significance to develop a system that can accurately simulate high-altitude conditions in a laboratory environment.

[0003] There are some devices on the market that simulate high altitude environments, but they generally have the following problems: (1) Incomplete simulation of environmental parameters: Most devices can only simulate changes in air pressure and oxygen content, while ignoring other important environmental factors such as temperature, humidity, and ultraviolet rays; (2) Insufficient accuracy and stability: Existing equipment is difficult to maintain the stability of environmental parameters during long-term operation, which affects the reliability of experimental results; (3) Low degree of automation: Many operations still require manual intervention, which increases experimental errors and affects experimental efficiency; (4) Lack of real-time monitoring and intelligent regulation: Environmental parameters cannot be adjusted according to the real-time physiological state of the animals, which limits the accuracy and flexibility of the experiment; (5) Poor scalability: It is difficult to flexibly adjust the system scale and function according to different experimental requirements.

[0004] Therefore, there is an urgent need to develop an animal experiment cabin system that can comprehensively, accurately and stably simulate high-altitude environments and have automated operation, real-time monitoring, intelligent adjustment and good scalability. Summary of the invention

[0005] In order to make up for the defects and shortcomings in the prior art, the present invention provides a high-precision high-altitude environment simulation animal experiment cabin system and method.

[0006] The present invention provides a high-precision high-altitude environment simulation animal experiment chamber system, comprising: an environment control chamber and an intelligent adjustment system, an animal physiological parameter real-time monitoring system, an automated feeding system, an automated sample collection system, a data processing center and a monitoring system; wherein the environment control chamber and the intelligent adjustment system are used to simulate and control the air pressure, oxygen content, temperature, humidity and gas composition radiation of the high-altitude environment; the animal physiological parameter real-time monitoring system is used to non-invasively monitor the physiological indicators and behavioral states of the experimental animals; the automated feeding system is used to automatically feed and drink water; Automated sample collection system for sample collection and waste disposal; The data processing center and monitoring system are used to process and analyze the animal experimental area and environmental data in real time, give corresponding feedback, and coordinate the work of each subsystem; Preferably, the environmental control air chamber and intelligent adjustment system include a pressure control unit, which uses a high-precision vacuum pump and a pressure sensor to adjust the air pressure in the cabin and simulate the air pressure changes at an altitude of 0-9000 meters; The gas mixing unit consists of an oxygen source, a nitrogen source and a mixer. By controlling the ratio of each gas component, the oxygen content can be adjusted to simulate the oxygen partial pressure at different altitudes. Temperature and humidity control unit, including cooling system, heating system and humidity adjustment device, to simulate the temperature and humidity changes in high altitude environment; UV simulation unit, equipped with UV lamps with adjustable intensity, simulates UV radiation in high altitude environments.

[0007] The environmental parameter sensor group, including air pressure sensor, oxygen content sensor, temperature sensor and humidity sensor, monitors the cabin environmental parameters in real time.

[0008] Preferably, the non-invasive physiological sensors include an electrocardiogram sensor, a respiratory sensor and a body temperature sensor; a weight detection device is located on the feeding platform and is used to measure the weight of the experimental animals while they are eating; and an image acquisition device is used to record animal behavior.

[0009] Preferably, the sample collection device comprises a blood collection unit and a feces collection unit.

[0010] Preferably, the data processing center and monitoring system mainly include: Data acquisition module: aggregates data flows from each subsystem; Data storage unit: adopts distributed storage architecture to ensure the safe storage of large amounts of experimental data; Real-time analysis engine: uses stream processing technology to quickly analyze real-time data; Machine Learning Module: Apply deep learning algorithms to predict animal adaptation processes and optimize experimental parameters; Visual interface: intuitively displays the experimental process and results, and supports interactive data exploration.

[0011] Preferably, it also includes an emergency system, which includes an emergency oxygen supply system, a rapid decompression device, a fault diagnosis system and a multi-level alarm mechanism.

[0012] The present invention also provides a high-precision high-altitude environment simulation animal experiment method, comprising the following steps: (1) According to the experimental plan, set the target environmental parameters through the data processing center and monitoring system; (2) The environmental control chamber and intelligent adjustment system adjust the cabin environment according to the set parameters; (3) The real-time monitoring system for animal physiological parameters continuously monitors the status of experimental animals; (4) The automated feeding and sample collection platform performs feeding and sample collection according to preset procedures; (5) The data processing center and monitoring system process monitoring data in real time and dynamically adjust environmental parameters and experimental operations in real time.

[0013] Preferably, step (5) includes predicting the animal adaptation process, optimizing the experimental parameters, and automatically adjusting the rate of change of environmental parameters according to the real-time physiological state of the experimental animals.

[0014] Compared with the prior art, the present invention has the following beneficial effects: (1) Comprehensiveness and accuracy of environmental simulation: It can simultaneously simulate multiple environmental factors such as air pressure, oxygen content, temperature, humidity, and UV radiation, providing experimental conditions that are closer to the real high-altitude environment for research; (2) Long-term stability: Through precise control systems and feedback mechanisms, the stability of environmental parameters during long-term experiments is ensured, thereby improving the reliability and repeatability of experimental results; (3) High degree of automation: greatly reduce manual intervention, reduce experimental errors, and improve experimental efficiency and data quality; (4) Real-time monitoring and intelligent regulation: Ability to dynamically adjust environmental parameters according to the real-time physiological state of animals, implement personalized experimental plans, and improve the accuracy and flexibility of research; (5) Good scalability: The modular design allows the system scale and function to be flexibly adjusted according to research needs, adapting to different types of high-altitude related research; (6) Safe and reliable: Multiple safety protection mechanisms ensure experimental safety under simulated extreme environmental conditions, protecting experimental animals and researchers; (7) Strong data analysis capabilities: The integrated data processing and analysis system can provide in-depth insights into experimental data, assisting researchers in optimizing experimental plans and interpreting results; (8) The high-precision high-altitude environment simulation animal experiment chamber system provided by the present invention can significantly improve the quality and efficiency of high-altitude environment-related research and provide important technical support for scientific breakthroughs in related fields. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a schematic diagram of the overall structure and each system of the high-precision high-altitude environment simulation animal experiment cabin system of the present invention. DETAILED DESCRIPTION

[0016] The present invention is described more completely and clearly below in conjunction with the accompanying drawings and specific embodiments. The described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0017] Example 1 Figure 1 As shown, the high-precision high-altitude environment simulation animal experiment cabin system provided by the present invention mainly includes the following parts: an environmental control air chamber and an intelligent adjustment system, a real-time monitoring system for animal physiological parameters, an automated feeding system, an automated sample collection system, a data processing center and a monitoring system, and an emergency system.

[0018] Each system is connected to the data processing center through a data bus to achieve information interaction and collaborative work. The entire system adopts a modular design and can be flexibly combined and expanded according to experimental requirements. The composition and functions of each subsystem are introduced as follows:

[0019] 1. Environmental control chamber and intelligent adjustment system The environmental control chamber and intelligent adjustment system mainly include the following components: Pressure control unit: uses a high-precision vacuum pump and pressure sensor to accurately adjust the cabin pressure and simulate the pressure changes at an altitude of 0-9000 meters.

[0020] Gas mixing unit: It consists of an oxygen source, a nitrogen source and a mixer. It adjusts the oxygen content by precisely controlling the gas ratio to simulate the oxygen partial pressure at different altitudes.

[0021] Temperature and humidity control unit: includes refrigeration system, heating system and humidity adjustment device, which can simulate the temperature and humidity changes in high altitude environment.

[0022] UV simulation unit: equipped with UV lamps with adjustable intensity to simulate the UV radiation of high altitude environments.

[0023] Environmental parameter sensor group: including air pressure sensor, oxygen content sensor, temperature sensor and humidity sensor, to monitor the cabin environmental parameters in real time.

[0024] The data processing center sends instructions to each unit according to the preset experimental plan. Each unit uses the PID control algorithm to accurately adjust and stably maintain environmental parameters based on the feedback sensor data.

[0025] 2. Real-time monitoring system of animal physiological parameters The real-time monitoring system of animal physiological parameters mainly includes: Non-invasive physiological sensors: including ECG sensors, respiration sensors and body temperature sensors, designed with wearable flexible materials to minimize interference to animals.

[0026] A weight detection device, located on the feeding platform, is used to measure the weight of the experimental animals while they are eating; Image acquisition device: High-resolution camera to record animal behavior.

[0027] The system continuously collects the physiological signals and behavioral data of animals and transmits the results to the data processing center for evaluating the animal's adaptation status and guiding the adjustment of environmental parameters.

[0028] 3. Automated feeding and sample collection system The automated feeding and sample collection system mainly includes: Automatic feeding device: timed and quantitative feeding is achieved through program-controlled robotic arms and quantitative feeders.

[0029] Automatic drinking water device: adopts the pressure balance principle to ensure a stable drinking water supply under different air pressures.

[0030] Sample collection device: includes a blood collection unit and an excrement collection unit, which can automatically collect biological samples without destroying the closed environment.

[0031] Waste treatment device: automatically collects and processes animal waste to maintain a sanitary environment in the cabin.

[0032] Each device runs automatically according to the preset program and makes real-time adjustments based on the instructions of the control unit to meet the needs of different experimental stages.

[0033] 4.Data processing center and monitoring system The data processing center and monitoring system mainly include: Data acquisition module: aggregates data flows from each subsystem.

[0034] Data storage unit: adopts a distributed storage architecture to ensure the safe storage of large amounts of experimental data.

[0035] Real-time analysis engine: Uses stream processing technology to quickly analyze real-time data.

[0036] Machine Learning Module: Apply deep learning algorithms to predict animal adaptation processes and optimize experimental parameters.

[0037] Visual interface: intuitively displays the experimental process and results, and supports interactive data exploration.

[0038] Responsible for coordinating the work of each subsystem: communicating directly with each execution unit to achieve basic parameter adjustment.

[0039] Dynamically adjust control strategies: realize intelligent decision-making and adaptive control based on preset experimental plans and real-time data.

[0040] The system continuously processes and analyzes data streams from other subsystems to generate real-time reports and warning information. At the same time, historical data is mined through machine learning models to provide decision support for experimental scheme optimization. Each cabin unit can be stacked vertically or connected horizontally to flexibly adjust the scale of the experiment.

[0041] 5. Emergency System The system integrates multiple security protection measures, including: Emergency oxygen supply system: automatically activated when oxygen content is abnormal.

[0042] Rapid decompression device: can quickly restore the cabin pressure to normal pressure when necessary.

[0043] Fault diagnosis system: Continuously monitor the working status of each unit and detect potential problems in time.

[0044] Multi-level alarm mechanism: trigger different levels of alarms according to the degree of abnormality.

[0045] Redundant design: Key components use double or triple redundancy to improve system reliability.

[0046] Through the above technical scheme, the high-precision high-altitude environment simulation animal experiment chamber system of the present invention can comprehensively, accurately and stably simulate the high-altitude environment, realize highly automated experimental operations and intelligent environmental control, and provide an advanced technical platform for high-altitude related research.

[0047] Embodiment 2 Based on the high-precision high-altitude environment simulation animal experiment chamber system provided in Embodiment 1, the high-precision high-altitude environment simulation animal experiment method of this embodiment includes the following steps: (1) According to the experimental plan, set the target environmental parameters through the data processing center and monitoring system; (2) The environmental control chamber and intelligent adjustment system adjust the cabin environment according to the set parameters; (3) The real-time monitoring system for animal physiological parameters continuously monitors the status of experimental animals; (4) The automated feeding and sample collection platform performs feeding and sample collection according to preset procedures; (5) The data processing center and monitoring system process monitoring data in real time and dynamically adjust environmental parameters and experimental operations in real time, for example: predicting the animal adaptation process and optimizing experimental parameters; automatically adjusting the rate of change of environmental parameters according to the real-time physiological state of the experimental animals, etc.

Claims

1. A high-precision high-altitude environment simulation animal experiment cabin system, characterized in that: include: Environmental control chamber and intelligent adjustment system, real-time monitoring system for animal physiological parameters, automated feeding system, automated sample collection system, data processing center and monitoring system; among them, the environmental control chamber and intelligent adjustment system are used to simulate and control the air pressure, oxygen content, temperature, humidity and gas composition radiation of high-altitude environment; the real-time monitoring system for animal physiological parameters is used to non-invasively monitor the physiological indicators and behavioral status of experimental animals; the automated feeding system is used to automatically feed and drink water; Automated sample collection system for sample collection and waste disposal; The data processing center and monitoring system are used to process and analyze the animal experimental area and environmental data in real time, give corresponding feedback, and coordinate the work of each subsystem.

2. The high-precision high-altitude environment simulation animal experiment chamber system according to claim 1 is characterized by: The environmental control air chamber and intelligent adjustment system include a pressure control unit, which uses a high-precision vacuum pump and a pressure sensor to adjust the air pressure in the cabin and simulate the air pressure changes at an altitude of 0-9000 meters; The gas mixing unit consists of an oxygen source, a nitrogen source and a mixer. By controlling the ratio of each gas component, the oxygen content can be adjusted to simulate the oxygen partial pressure at different altitudes. Temperature and humidity control unit, including cooling system, heating system and humidity adjustment device, to simulate the temperature and humidity changes in high altitude environment; UV simulation unit, equipped with UV lamps with adjustable intensity, simulates UV radiation in high altitude environments.

3. Environmental parameter sensor group, including air pressure sensor, oxygen content sensor, temperature sensor and humidity sensor, to monitor the cabin environmental parameters in real time.

4. The high-precision high-altitude environment simulation animal experiment chamber system according to claim 1 is characterized by: The non-invasive physiological sensors include electrocardiogram sensors, respiratory sensors and body temperature sensors; the weight detection device is located on the feeding platform and is used to measure the weight of the experimental animals while they are eating; and the image acquisition device is used to record animal behavior.

5. The high-precision high-altitude environment simulation animal experiment chamber system according to claim 1 is characterized by: The sample collection device includes a blood collection unit and a feces collection unit.

6. The high-precision high-altitude environment simulation animal experiment chamber system according to claim 1 is characterized by: The data processing center and monitoring system mainly include: Data acquisition module, which aggregates data streams from various subsystems; The data storage unit adopts a distributed storage architecture to ensure the safe storage of large amounts of experimental data; Real-time analysis engine, using stream processing technology to quickly analyze real-time data; Machine learning module, which applies deep learning algorithms to predict animal adaptation processes and optimize experimental parameters; The visual interface intuitively displays the experimental process and results and supports interactive data exploration.

7. The high-precision high-altitude environment simulation animal experiment chamber system according to claim 1 is characterized by: It also includes an emergency system, which includes an emergency oxygen supply system, a rapid decompression device, a fault diagnosis system and a multi-level alarm mechanism.

8. A high-precision high-altitude environment simulation animal experiment method, characterized in that: The following steps are involved: (1) According to the experimental plan, set the target environmental parameters through the data processing center and monitoring system; (2) The environmental control chamber and intelligent adjustment system adjust the cabin environment according to the set parameters; (3) The real-time monitoring system for animal physiological parameters continuously monitors the status of experimental animals; (4) The automated feeding and sample collection platform performs feeding and sample collection according to preset procedures; (5) The data processing center and monitoring system process monitoring data in real time and dynamically adjust environmental parameters and experimental operations in real time.

9. The high-precision high-altitude environment simulation animal experiment method according to claim 7, characterized in that: Step (5) involves predicting the animal adaptation process and optimizing experimental parameters.

10. The high-precision high-altitude environment simulation animal experiment method according to claim 7, characterized in that: Step (5) includes automatically adjusting the rate of change of environmental parameters according to the real-time physiological state of the experimental animal.

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