Insecticidal aerosol

Abstract

The invention discloses an insecticidal aerosol which comprises the following components in percentage by weight: 0.01%-4% of an active component, 0.1%-70% of a solvent, 26%-90% of a propellant and 2%-10% of plant essential oil, the active component is a piperic acid derivative compound as shown in a formula I; the insecticidal aerosol composition disclosed by the invention has the advantages of high knockdown speed and high fatality rate on pests such as mosquitoes, flies and German cockroaches.

Description

Technical Field

[0001] The present invention relates to an insecticidal aerosol, in particular to an insecticidal aerosol containing a piperic acid derivative compound, which is used for preventing and controlling mosquitoes, flies, German cockroaches and other sanitary pests. Background Art

[0002] Currently, pyrethroid compounds are still the main ingredients in the aerosol market. However, with years of use, sanitary pests such as mosquitoes, flies, or German cockroaches have developed resistance to some traditional insecticides, resulting in a decrease in protection effectiveness.

[0003] Chinese invention patent CN112457288 discloses a piperic acid derivative and its application, wherein compound I-72 has contact and stomach poison activity and good conduction activity. At the same time, compound I-72 has not been used in aerosols so far. It has the characteristics of high knockdown and lethal activity and low toxicity. The higher activity can reduce the amount of effective ingredients used per unit area, which is in line with the national policy of increasing efficiency and reducing application. It is developed into an aerosol formulation for the first time, and the drug resistance of vector organisms is low, which improves the control effect of vector organisms. The structural formula of the compound is as follows:

[0004]

[0005] By adding plant essential oils to aerosols, the permeability and adhesion of spray droplets to sanitary pests are improved, and the utilization rate of pesticides is improved by increasing the efficacy. Summary of the invention

[0006] The technical problem to be solved by the present invention is to provide an insecticidal aerosol in view of the deficiencies in the prior art. The aerosol has a piperic acid derivative compound (compound I-72) as a main component and has a very good control effect on sanitary pests such as mosquitoes, flies, German cockroaches, American cockroaches, bedbugs, ants, fleas, etc. At the same time, a preparation method of the insecticidal aerosol and its application in controlling sanitary pests are also provided.

[0007] In order to achieve the above object, the present invention adopts the following technical solution:

[0008] An insecticide aerosol comprises the following components in weight percentage: 0.01%-4% of an active ingredient, 0.1%-70% of a solvent, 26%-90% of a propellant, and 2%-10% of a plant essential oil; the active ingredient is a piperic acid derivative compound shown in formula I (referred to as compound I-72);

[0009]

[0010] In the above technical scheme, the solvent is any one of C8-18 alkane solvents, amide solvents, monoester solvents, diester solvents, alcohol ether solvents, C2-8 alcohol solvents, water, dodecylbenzene, decaprylbenzene, or a mixture of two or more solvents in any proportion, wherein:

[0011] The C8-18 alkane solvent is preferably D60 (ExxonMobil Petrochemical Company), D80 (ExxonMobil Petrochemical Company), D100 (ExxonMobil Petrochemical Company), D110 (ExxonMobil Petrochemical Company), Isopar-E (ExxonMobil Petrochemical Company), Isopar-G (ExxonMobil Petrochemical Company), Isopar-H (ExxonMobil Petrochemical Company), Isopar-L (ExxonMobil Petrochemical Company), Isopar-M (ExxonMobil Petrochemical Company), octane, nonane, quinane, undecane, dodecane, tridecane, tetradecane, pentadecane, hexadecane, or any mixture of two or more in any proportion.

[0012] The amide solvent is preferably N,N-dimethyl butyl amide;

[0013] The monoester solvent is preferably γ-butyrolactone; any one of methyl oleate, isopropyl tridecanoate, isopropyl myristate, isopropyl hexadecanoate, isopropyl phenylacetate, ethyl phenylacetate, and n-butyl myristate, or a mixture of two or more of the above in any proportion;

[0014] The diester solvent is preferably any one of diisopropyl glutarate, diisopropyl adipate, and diisobutyl adipate, or a mixture of two or more of the above in any proportion;

[0015] The alcohol ether solvent is preferably a triester solvent such as tributyl citrate, acetyl tributyl citrate, etc.; any one of triethylene glycol monobutyl ether, diethylene glycol monobutyl ether, propylene glycol methyl ether, and dipropylene glycol propyl ether, or a mixture of two or more of them in any proportion;

[0016] The C2-8 alcohol solvent is preferably any one of ethanol, isopropanol, n-propanol, n-butanol, sec-butanol, tert-butanol, n-pentanol and its isomers, n-hexanol and its isomers, n-heptanol and its isomers, n-octanol and its isomers, or a mixture of two or more in any proportion.

[0017] In the above technical solution, the propellant is any one of liquefied petroleum gas, propane, butane, dimethyl ether or compressed air.

[0018] In the above technical scheme, the plant essential oil is any one of artemisia oil, cottonseed oil, prickly ash oil, citronella oil, clove oil and geranium oil.

[0019] In the above technical solution, the insecticide aerosol may further include pyrethroid compounds, and the weight ratio of pyrethroid compounds to piperic acid derivative compounds is 2:1 to 1:3.

[0020] In the above technical solution, the pyrethroid is any one of tetrafluthrin, transfluthrin, d-trans-chlorpromazine, and bio-allethrin.

[0021] The present invention also provides a method for preparing the insecticidal aerosol, comprising the following steps: mixing the piperic acid derivative compounds, solvents, plant essential oils (and pyrethroid compounds) in the proportions described above at room temperature or under heating (20°C-50°C), then adding the mixture into a spray can with a common spray valve or a control valve (valve 0.02ml-1ml), and adding a propellant into the can under pressure through the control valve to obtain the insecticidal aerosol.

[0022] The invention also provides an application of the insecticide aerosol in preventing and controlling sanitary pests.

[0023] In the above technical solution, the sanitary pests refer to mosquitoes, flies, German cockroaches, American cockroaches, bedbugs, ants, fleas, bees, etc.

[0024] In the above technical solution, when the insecticide aerosol is used to control sanitary pests, it is applied through a control valve and sprayed 2 or more times in a certain space. The number of sprays is determined according to the size of the space, and an average of 1 spray per 5m3.

[0025] The insecticidal aerosol of the present invention, when in use: the valve of the control valve is opened, and a high-speed airflow is generated under the pressure of the propellant, and the vaporization energy of the propellant is used to disperse and atomize the effective component liquid in the tank, forming small droplets suspended in the air, which contact with hygienic pests such as mosquitoes, flies, cockroaches, etc., thereby achieving the purpose of quickly controlling and killing the pests. Through the efficacy experiment, it is proved that the insecticidal aerosol of the present invention has the characteristics of fast knockdown and high mortality rate for hygienic pests such as Culex pipiens pallens, houseflies, German cockroaches, etc., and the prevention effect is better than that of the control agent. DETAILED DESCRIPTION

[0026] The specific implementation of the technical solution of the present invention is described in detail below, but the present invention is not limited to the following description:

[0027] The preparation method of the dosage form in each embodiment of the present invention is as follows: Compound I-72, solvent, plant essential oil and pyrethroid compound in the stated proportion are mixed at room temperature and added to a spray tank equipped with a control valve, and a propellant is added into the tank under pressure through the control valve to prepare the dosage form.

[0028] The present invention will be described below in conjunction with specific embodiments:

[0029] Formulation Example 1: 0.3% Compound I-72 Aerosol

[0030] Compound I-720.3g, artemisia oil 2g, diisopropyl adipate 42.7g, propane-butane 55g, an aerosol was prepared according to the above method.

[0031] Formulation Example 2: 0.3% Compound I-72 Aerosol

[0032] Compound I-720.3g, citronella oil 4g, dipropylene glycol propyl ether 10g, ethanol 20.7g, n-butanol 10g, liquefied petroleum gas 55g, an aerosol was prepared according to the above method.

[0033] Formulation Example 3: 0.4% Compound I-72 Aerosol

[0034] Compound I-720.4g, prickly ash oil 5g, dipropylene glycol propyl ether 10g, ethanol 58.6g, propane-butane 26g, were used to prepare an aerosol according to the above method.

[0035] Formulation Example 4: 0.4% Compound I-72 Aerosol

[0036] Compound I-720.4g, geranium oil 6g, D11040.6g, propane-butane 53g, an aerosol was prepared according to the above method.

[0037] Formulation Example 5: 0.5% Compound I-72 Aerosol

[0038] Compound I-720.5g, citronella oil 5g, D11044.5g, liquefied petroleum gas 50g, an aerosol was prepared according to the above method.

[0039] Formulation Example 6: 0.5% Compound I-72 Aerosol

[0040] Compound I-72 0.5 g, D803 0.5 g, Isopar-M 10 g, citronella oil 9 g, propane and butane 50 g, an aerosol was prepared according to the above method.

[0041] Formulation Example 7: 0.6% Compound I-72 Aerosol

[0042] Compound I-720.6g, cottonseed oil 5g, Isopar-E 34.4g, Isopar-L 15g, propane-butane 45g, an aerosol is prepared according to the above method.

[0043] Formulation Example 8: 0.6% Compound I-72 Aerosol

[0044] Compound I-720.6g, cottonseed oil 5g, D8023.4g, D11021g, propane 50g, an aerosol was prepared according to the above method.

[0045] Formulation Example 9: 0.7% Compound I-72 Aerosol

[0046] Compound I-720.7g, artemisia oil 2g, dipropylene glycol propyl ether 14.3g, diisopropyl adipate 28g, water 5g, propane 50g, and an aerosol is prepared according to the above method.

[0047] Formulation Example 10: 0.7% Compound I-72 Aerosol

[0048] Compound I-720.7g, geranium oil 5g, dipropylene glycol propyl ether 14g, ethanol 30.3g, liquefied petroleum gas 50g, an aerosol was prepared according to the above method.

[0049] Formulation Example 11: 0.7% Compound I-72 Aerosol

[0050] Compound I-720.7g, geranium oil 5g, dipropylene glycol propyl ether 15g, isopropanol 14.3g, water 10g, propane-butane 55g, are used to prepare an aerosol according to the above method.

[0051] Formulation Example 12: 0.01% Compound I-72 Aerosol

[0052] Compound I-72 0.01 g, clove oil 2 g, D602 4.99 g, D802 3 g, propane 50 g, an aerosol was prepared according to the above method.

[0053] Formulation Example 13: 0.1% Compound I-72 Aerosol

[0054] Compound I-720.1g, pepper oil 2g, diisopropyl adipate 27.9g, D11020g, propane-butane 50g, an aerosol was prepared according to the above method.

[0055] Formulation Example 14: 0.15% Compound I-72 Aerosol

[0056] Compound I-72 0.15 g, bio-allethrin 0.05 g, geranium oil 5 g, dipropylene glycol propyl ether 15 g, n-butanol 6.8 g, ethanol 15 g, water 8 g, propane 50 g, an aerosol is prepared according to the above method.

[0057] Formulation Example 15: 0.2% Compound I-72 Aerosol

[0058] Compound I-720.2g, tetrafluthrin 0.1g, artemisia oil 6g, diisopropyl adipate 21.7g, D11022g, dimethyl ether 50g, an aerosol was prepared according to the above method.

[0059] Formulation Example 16: 1.0% Compound I-72 Aerosol

[0060] Compound I-721.0g, right-rotating trans-chlorpropyl thrin 0.2g, prickly ash oil 5g, diisopropyl adipate 28.8g, D11020g, dimethyl ether 45g, an aerosol was prepared according to the above method.

[0061] Formulation Example 17: 1.0% Compound I-72 Aerosol

[0062] Compound I-721.0g, pepper oil 5g, diisopropyl adipate 29g, D11020g, dimethyl ether 45g, an aerosol was prepared according to the above method.

[0063] Formulation Example 18: 2.0% Compound I-72 aerosol

[0064] Compound I-7 22g, clove oil 8g, Isopar-E 24g, Isopar-L 21g, propane 45g, an aerosol was prepared according to the above method.

[0065] Formulation Example 19: 3.0% Compound I-72 Aerosol

[0066] Compound I-7 23g, artemisia oil 7g, diisopropyl adipate 25g, D110 15g, dimethyl ether 50g, an aerosol was prepared according to the above method.

[0067] Formulation Example 20: 4.0% Compound I-72 Aerosol

[0068] Compound I-7 24g, clove oil 10g, diisopropyl adipate 10g, dodecylbenzene 20g, D1106g, liquefied petroleum gas 50g, an aerosol is prepared according to the above method.

[0069] Comparative Example 1: 0.4% Compound I-72 Aerosol

[0070] Compound I-7 20.4g, D110 46.6g, propane 53g, an aerosol was prepared according to the above method.

[0071] Comparative Example 2: 0.5% Compound I-72 Aerosol

[0072] Compound I-720.5g, D11049.5g, liquefied petroleum gas 50g, an aerosol was prepared according to the above method.

[0073] Comparative Example 3: 0.5% Compound I-72 Aerosol

[0074] Compound I-720.5g, D8039.5g, Isopar-M 10g, propane 50g, an aerosol was prepared according to the above method.

[0075] Control agent 1: 0.6% tetramethrin-permethrin aerosol (commercially available, composed of 0.3% tetramethrin + 0.3% permethrin)

[0076] Verification test 1: Cylindrical aerosol efficacy test

[0077] Test agents: Preparation Examples 1, 4, 5, 6, 7, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 of the present invention, Comparative Example 1, Comparative Example 2, Comparative Example 3 and Control Agent 1

[0078] Test insects: Culex pipiens pallens, female adults that have not sucked blood on the 3rd to 5th day after emergence

[0079] Housefly, 3-4 days after emergence, half male and half female

[0080] German cockroach, 10-15 days old, half male and half female

[0081] Test method: Refer to GB / T 13917.2-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration Part 2: Aerosol method.

[0082] Mosquitoes and flies: Use a cylinder device. The specific method is to put the test insects (30 houseflies, or 30 mosquitoes) into the cylinder. After the test insects resume normal activities, place the aerosol cylinder to be tested horizontally, with the nozzle pointing vertically downward, aiming at the spray hole, spray the agent (1.0±0.1g), and immediately plug the round hole with a rubber stopper (G). After 1 minute, remove the pull plate (A), start timing immediately, and record the number of knocked-down test insects at regular intervals. After 20 minutes, move the knocked-down test insects to a clean insect cage, restore the feeding standard, and feed them with 5% sugar water cotton balls. Check the number of dead insects for 24 hours, and the test insects that have not been knocked down will be counted as live insects. The test should be repeated three times or more. The test device should be cleaned at the end of each test.

[0083] Cockroaches: Use a cylindrical device without pulling the board. Place 20 German cockroaches in a cylinder B with a circle of vaseline on the upper inner wall and sealed with a 12-mesh iron screen. After the test insects resume normal activities, place the aerosol cylinder horizontally, aim the nozzle vertically downward at the spray hole on E, spray the agent (1.0±0.1g), immediately plug the round hole with a rubber stopper (G), start timing, and record the number of knocked-down test insects at regular intervals. After 20 minutes, transfer all the test insects to a clean container and resume standard feeding. Feed with mixed feed blocks and soaked cotton balls, and check the number of dead insects for 72 hours. The test should be repeated three times or more. At the end of each test, the test device should be cleaned. The detailed results are shown in the following table:

[0084] Table 1 Results of the efficacy test of the above aerosols against Culex pipiens pallens, housefly, and German cockroach

[0085]

[0086]

[0087] As can be seen from Table 1, the aerosol of the present invention has a good killing effect on Culex pipiens pallens, housefly and German cockroach.

[0088] The above examples are only for illustrating the technical concept and technical features of the present invention, and cannot be used to limit the protection scope of the present invention. Any equivalent transformation or modification made according to the essence of the present invention should be included in the protection scope of the present invention.

Claims

1. An insecticide aerosol, characterized in that: The invention comprises the following components in weight percentage: 0.01%-4% of active ingredient, 0.1%-70% of solvent, 26%-90% of propellant, and 2%-10% of plant essential oil; the active ingredient is a piperic acid derivative compound shown in formula I (referred to as compound I-72); 2. The insecticide aerosol according to claim 1, characterized in that: The solvent is any one of C8-18 alkane solvents, amide solvents, monoester solvents, diester solvents, alcohol ether solvents, C2-8 alcohol solvents, water, dodecylbenzene, decaprylbenzene, or a mixture of two or more of them in any proportion.

3. The insecticide aerosol according to claim 1, characterized in that: The propellant is any one of liquefied petroleum gas, propane, butane, dimethyl ether or compressed air.

4. The insecticide aerosol according to claim 1, characterized in that: The plant essential oil is any one of artemisia oil, cottonseed oil, prickly ash oil, citronella oil, clove oil and geranium oil.

5. The insecticide aerosol according to claim 1, characterized in that: The insecticide aerosol may further include pyrethroid compounds, and the weight ratio of the pyrethroid compounds to the piperic acid derivative compounds is 2:1 to 1:

3.

6. The insecticide aerosol according to claim 5, characterized in that: The pyrethroid is any one of tetrafluthrin, transfluthrin, d-trans-chlorpromazine and bio-allethrin.

7. Use of the insecticide aerosol according to any one of claims 1 to 6 in controlling sanitary pests.

8. The use according to claim 7, characterized in that: The sanitary pests include mosquitoes, flies, German cockroaches, American cockroaches, bed bugs, ants, fleas, bees and the like.

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