Anti-dandruff oil-control composition and preparation method thereof

Abstract

The invention discloses an anti-dandruff and oil-control composition and a preparation method thereof, the anti-dandruff and oil-control composition comprises the following raw material components in percentage by mass: 0.2-3% of supramolecular capryloyl glycine, 0.1-3% of nicotinamide, 0.5-3% of Haiyujing, 0.05-0.15% of dichlorobenzyl alcohol, 0.02-0.1% of hexamidine dihydroxyethyl sulfonate and the balance of water, and the pH value of the anti-dandruff and oil-control composition is less than 9.04 and greater than 3.5. The supramolecular capryloyl glycine adopted by the invention forms a supramolecular structure under the electrostatic interaction, the supramolecular capryloyl glycine is added into the anti-dandruff oil-control composition, and the supramolecular capryloyl glycine and the Haiyujin have a coordination effect, so that the anti-dandruff oil-control composition has an excellent inhibition effect on both demodex mites and malassezia, and the anti-dandruff oil-control composition has a good anti-dandruff oil-control effect. Therefore, after the shampoo prepared from the anti-dandruff and oil-control composition is used, the phenomenon of oil head does not occur within 12-24 hours.

Description

Technical Field

[0001] The present invention particularly relates to an anti-dandruff and oil-controlling composition and a preparation method thereof. Background Art

[0002] In people's daily life, shampoo is a very common bathing product. Its use is very common. There are many shampoo products with different functions on the market, which mainly focus on basic aspects such as cleaning, nourishing, and removing dandruff. For example, the application of Haisiyue in shampoo is less irritating than traditional dandruff removers, does not hurt the scalp, does not damage the scalp barrier, has a certain inhibitory effect on Malassezia, and has a certain alleviating effect on the dandruff symptoms caused by Malassezia. The antibacterial rate of Malassezia is greater than 99%, which can be completely biodegraded, has little impact on aquatic organisms, and has no risk of ecological pollution. However, there are the following problems: For patients with dandruff, Malassezia can be significantly inhibited, but consumers report that the phenomenon of oily scalp is more obvious. After many experiments and evidence collection, the scientific research team found that although Haisiyue has excellent antibacterial effect on Malassezia, it is not obvious for Demodex. Because Demodex can stimulate excessive secretion of scalp oil, consumers will find that dandruff is reduced when using this type of shampoo, but the phenomenon of oily hair is serious. Summary of the invention

[0003] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides an anti-dandruff and oil-control composition and a preparation method thereof.

[0004] In order to solve the above-mentioned technical problems, the present invention adopts the following technical solutions:

[0005] A dandruff-removing and oil-controlling composition comprises the following raw material components in percentage by weight: 0.2-3% supramolecular capryloyl glycine, 0.1-3% niacinamide, 0.5-3% Hisejoy, 0.05-0.15% dichlorobenzyl alcohol, 0.02-0.1% hexamidine dihydroxyethyl sulfonate, and the balance is water. The pH value of the dandruff-removing and oil-controlling composition is less than 9.04 and the pH value is greater than 3.5.

[0006] Preferably, the Haisiyue comprises water, glycerin, hydrolyzed corn starch, acrylic acid (ester) / acrylamide copolymer, hydrolyzed chitosan, polysorbate-20, and quaternary ammonium salt-73.

[0007] The method for preparing the above-mentioned anti-dandruff and oil-control composition comprises the following steps:

[0008] (1) dispersing quaternary ammonium salt-73 in glycerol, adding polysorbate-20, heating to 80-90° C., stirring and dispersing, cooling to 65-75° C. and keeping warm for later use, to obtain a mixed solution;

[0009] (2) dissolving the hydrolyzed chitosan in water at 15-40° C., heating to 75-85° C., stirring and dispersing, adding acrylate / acrylamide copolymer, stirring and dispersing, cooling to 15-40° C., adding hydrolyzed corn starch, stirring and dispersing, and finally adding the mixed solution described in step (1), stirring and dispersing, to obtain the Haisiyue;

[0010] (3) Niacinamide is pre-dispersed with pure water to form a niacinamide aqueous solution. The Haisiyue prepared in step (2) is put into a reaction pot, and dichlorobenzyl alcohol is added. The supermolecular octanoyl glycine is heated to 75-85° C., stirred and dissolved evenly, cooled to 50-60° C., and hexamidine dihydroxyethyl sulfonate is added. The temperature is further cooled to below 45° C., and the niacinamide aqueous solution is added and stirred evenly to obtain an anti-dandruff and oil-control composition.

[0011] The beneficial effects of the present invention are:

[0012] The supramolecular capryloyl glycine used in the present application forms a supramolecular structure under electrostatic interaction. When supramolecular capryloyl glycine is added to the anti-dandruff and oil-control composition, the coordinated effect of supramolecular capryloyl glycine and Haisiyue has an excellent inhibitory effect on Demodex and Malassezia. Therefore, after using the shampoo prepared with the anti-dandruff and oil-control composition of the present application, the phenomenon of oily hair will not occur for up to 12-24 hours. DETAILED DESCRIPTION

[0013] The present invention will be further described below in conjunction with specific embodiments. The illustrative embodiments and descriptions of the present invention are used to explain the present invention but are not intended to limit the present invention.

[0014] Preparation of Haisiyue: 3.0% hydrolyzed chitosan, 7.0% hydrolyzed corn starch, 0.02% quaternary ammonium salt-73, 4.8% acrylate / acrylamide copolymer, 19.5% glycerol, 2.0% polysorbate-20, and the remainder water (the mass percentage content of all the above raw materials is calculated as 100%). (1) First, disperse the quaternary ammonium salt-73 in glycerol, then add polysorbate-20, then heat to 85°C, stir at 1000rpm for 0.5h, cool to 65°C and keep warm for later use; (2) At 25°C, dissolve the hydrolyzed chitosan in water, heat to 75°C, stir at 50rpm for 0.5h until uniformly dispersed, then add acrylate / acrylamide copolymer, continue stirring at 60rpm for 4h until uniformly dispersed, cool to 25°C, then add hydrolyzed corn starch, continue stirring at 70rpm for 0.5h until uniformly dispersed, finally add the solution obtained in step (1), stir at 50rpm for 0.5h, and obtain Haisiyue.

[0015] Preparation of anti-dandruff and oil-control composition:

[0016] Niacinamide is pre-dispersed with 1% pure water to form a niacinamide aqueous solution, the prepared Haisiyue is put into a reaction pot, dichlorobenzyl alcohol is added, and the temperature of supramolecular capryloyl glycine is raised to 75-85°C, stirred and dissolved evenly, cooled to 50-60°C, hexamidine dihydroxyethyl sulfonate is added, and the temperature is continued to be lowered to below 45°C, and the niacinamide aqueous solution is added and stirred evenly to obtain an anti-dandruff and oil-control composition.

[0017] Preparation method of shampoo 1:

[0018] 1. Add room temperature pure water to the main pot, slowly sprinkle in carbomer, soak for 30 minutes, and when there are no insoluble particles, start stirring at 25 rpm, pump in AES, turn on steam, raise the temperature to 65-75℃, add sodium lauroylamphoacetate, sodium lauroyl glutamate, CMEA, pearlescent flakes, stir until completely dissolved, keep warm for 20 minutes, and set aside.

[0019] 2. After the material is completely dissolved, turn on the cooling water to cool down to 60°C, add C14-16 sodium olefin sulfonate aqueous solution and anti-dandruff oil control composition, stir for 20 minutes, observe that the material is completely dispersed, continue to cool to 45°C, add emulsified silicone oil, CAB-35C, essence, stir evenly, and use industrial salt to adjust the viscosity of the system to the qualified range.

[0020] 3. Take samples for inspection, pack them if qualified, and put them into storage if qualified.

[0021] The preparation methods of Shampoo 2, Shampoo 3 and Shampoo 4 can refer to Shampoo 1.

[0022] Table 1 Experimental formula control experiment

[0023]

[0024]

[0025] Table 2 Numbers of Demodex and Malassezia in scalp samples of different volunteers (before using shampoo)

[0026]

[0027] Table 3 The number of Demodex mites and Malassezia in scalp samples of different volunteers after using different shampoos for 1 week

[0028]

[0029]

[0030] The volunteers of this application all suffer from moderate dandruff, because their oily scalp phenomenon and the presence of Demodex mites and Malassezia are more representative and easier to observe.

[0031] Table 4 The usage experience of different volunteers' scalp samples after using different shampoos for 1 week

[0032]

[0033] As can be seen from Table 2, Haisiyue itself has a strong antibacterial effect on Malassezia, that is, it has an excellent anti-dandruff effect, so the number of Malassezia microscopic examinations of shampoo 1-shampoo 4 showed a significant decrease; however, according to the test of volunteers using the samples of shampoo 2-4, the volunteers' hair became oily 8-12 hours after use; combined with the data in Table 3, after using shampoo 2-shampoo 4, there was no trend of decrease in Demodex mites, and there was even a trend of increase, that is to say, although the use of shampoo 2-4 can inhibit the production of Malassezia, it has a certain anti-dandruff effect. However, because Demodex mites still live in hair follicles, stimulating the hair follicles to swell and expand, a large amount of oil accumulates to provide nutrients for Demodex mites, and the nutrients required by Malassezia and Demodex mites are the same, so in the test results, some volunteers will soon have different degrees of oily hair, and even some will have dandruff. That is to say, the tests of shampoos 2-4 prove that Haisiyue is difficult to solve the oily scalp problem caused by Demodex mites by simply compounding conventional octanoyl glycine, arginine and other substances. In order to solve the above problem, the present application adds supramolecular octanoyl glycine to the formula. The supramolecular octanoyl glycine of the present application is purchased from Ascend Biotech LLC, USA, and the structural formula is as follows:

[0034]

[0035] The supramolecular capryloyl glycine used in the present application forms a supramolecular structure under electrostatic interaction. The supramolecular capryloyl glycine is added to the anti-dandruff and oil-control composition. By comparing the data in Table 2 and Table 3, it can be seen that the coordination between the supramolecular capryloyl glycine and Haisiyue has an excellent inhibitory effect on both Demodex and Malassezia. Therefore, after using the shampoo prepared in Example 1 of the present application, the phenomenon of oily hair will not occur for up to 12-24 hours.

[0036] In the above experiment, only when the pH of the shampoo satisfies: 3.5<pH<9.04, can the supramolecular capryloyl glycine have a supramolecular structure, so the anti-dandruff and oil-control composition of the present application can only be used in shampoos, lotions or other application products with a specific pH, and the anti-dandruff and oil-control composition of the present application must also satisfy 3.5<pH<9.04.

[0037] 5α-reductase inhibition rate

[0038] In order to further explore the role of supramolecular capryloyl glycine in the formulation system, this application also conducted the following comparative experiments:

[0039] Experimental materials and methods

[0040] Instruments and equipment: BSA224S Analyzer, Tianping, Gilent 1220 HPLC

[0041] Reagents Testosterone, 98% NADPH, 90% methanol, HPLC grade Buffer: Tris-HCl

[0042] Test methods

[0043] Handling of control and test samples

[0044] Sample group: diluted with buffer to a sample concentration of 20%;

[0045] Positive control (finasteride, purity ≥98%): diluted with methanol to a positive control concentration of 0.1%; negative control: Tris-HCl buffer.

[0046] Test operation steps

[0047] A sample group, a positive control group, a negative control group and a blank group were set up. Three parallels were set up for each group. Different reagent solutions were added to the four groups respectively, and the mixture was shaken well. Each group was subjected to HPLC analysis to determine the testosterone content in each tube.

[0048] Calculation formula

[0049]

[0050] Data analysis

[0051] The statistical analysis software was SPSS, and the comparison of 5α-reductase inhibition rates among the test samples, positive controls, and negative controls was performed using an independent sample t-test. The above statistical analyses were all two-tailed tests, with a significance level of α = 0.05. P>0.05 indicated that there was no significant difference between the two groups; P<0.05 indicated that there was a significant difference between the two groups.

[0052] Taking Shampoo D as an example, the addition amount of supramolecular capryloylglycine corresponds to that of Shampoo 1, and the addition amount of Haisiyue corresponds to that of Shampoo 1, and other amounts remain unchanged, and the 5α-reductase inhibition rate / % is tested.

[0053] Table 5 Haisiyue + Ordinary Capryloyl Glycine

[0054]

[0055] Table 6 Supramolecular Capryloyl Glycine + Haisiyue

[0056]

[0057] The 5α-reductase inhibition rates of shampoo A and shampoo B are 20.692% and 16.904% respectively; the 5α-reductase inhibition rates of shampoo C, shampoo D, shampoo E and shampoo F are 22.580%, 30.355%, 26.522% and 30.852% respectively. In other words, the combination of Haisiyue and supramolecular capryloyl glycine has a synergistic effect in oil control.

[0058] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

[0059] Although the present invention is described in detail with reference to the above embodiments, it is obvious to those skilled in the art through this disclosure that various changes or modifications may be made to the present invention without departing from the principle and spirit of the present invention defined by the claims. Therefore, the detailed description of the embodiments of the present disclosure is only used to explain, not to limit the present invention, but the scope of protection is limited by the content of the claims.

Claims

1. An anti-dandruff and oil-control composition, characterized in that: The composition comprises the following raw material components in percentage by weight: 0.2-3% supramolecular capryloyl glycine, 0.1-3% nicotinamide, 0.5-3% Hisejoy, 0.05-0.15% dichlorobenzyl alcohol, 0.02-0.1% hexamidine dihydroxyethyl sulfonate, and the balance is water. The anti-dandruff and oil-control composition has a pH value of less than 9.04 and a pH value of more than 3.

5.

2. The anti-dandruff and oil-control composition according to claim 1, characterized in that: The Hisejoy comprises water, glycerin, hydrolyzed corn starch, acrylic acid (ester) / acrylamide copolymer, hydrolyzed chitosan, polysorbate-20, and quaternary ammonium salt-73.

3. A method for preparing an anti-dandruff and oil-control composition as claimed in claim 2, characterized in that: The steps include: (1) dispersing quaternary ammonium salt-73 in glycerol, adding polysorbate-20, heating to 80-90° C., stirring and dispersing, cooling to 65-75° C. and keeping warm for later use, to obtain a mixed solution; (2) dissolving the hydrolyzed chitosan in water at 15-40° C., heating to 75-85° C., stirring and dispersing, adding acrylate / acrylamide copolymer, stirring and dispersing, cooling to 15-40° C., adding hydrolyzed corn starch, stirring and dispersing, and finally adding the mixed solution described in step (1), stirring and dispersing, to obtain the Haisiyue; (3) Niacinamide is pre-dispersed with water to form a niacinamide aqueous solution, the Haisiyue prepared in step (2) is put into a reaction pot, dichlorobenzyl alcohol is added, and the temperature of supramolecular capryloyl glycine is raised to 75-85° C., stirred and dissolved evenly, cooled to 50-60° C., hexamidine dihydroxyethyl sulfonate is added, and the temperature is further lowered to below 45° C., and the niacinamide aqueous solution is added and stirred evenly to obtain an anti-dandruff and oil-control composition.

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