Skin bottom repairing essence and preparation method thereof

Abstract

The invention relates to the technical field of skin care products, in particular to the field of IPC A61K8, and further relates to skin bottom repairing essence and a preparation method thereof. The raw materials comprise, by mass, 2-10% of a composition A, 1-5% of a composition B, 2-6% of a composition C, 0.1-0.4% of a composition D, and the balance deionized water; the composition A at least comprises a fibronectin mixture; the composition B at least comprises heteropolysaccharide; the composition C at least comprises polyol with the carbon atom number of 3-6; the composition D at least comprises triethanolamine. The technical scheme of the application not only has an excellent repairing effect, but also solves the stability problem of the fibronectin and the Chinese herbaceous peony root extract.

Description

Technical Field

[0001] The present invention relates to the technical field of skin care products, in particular to the field of IPC A61K8, and further to a skin base repairing essence and a preparation method thereof. Background Art

[0002] With the continuous improvement of living standards, more and more people are beginning to pay attention to skin management; for people with combination skin, sensitive skin, thin skin stratum corneum, and perennial acne, repair products are essential.

[0003] Chinese patent CN 202210866438 discloses a deep repair essence and its preparation method, which includes the following components by mass fraction: 8-10 parts of yeast fermentation lysate filtrate; 8-10 parts of retinol palmitate; 20-30 parts of plant extract; 5-10 parts of emulsifier; 10-15 parts of antioxidant; 8.5-16 parts of moisturizer; 1.5-3.5 parts of preservative; 45-85 parts of solvent. However, the molecular weight of retinol palmitate in this technical solution is relatively large, and there are problems of poor permeability and poor moisturizing effect. Summary of the invention

[0004] In order to solve the above technical problems, the first aspect of the present invention provides a skin repair essence, which comprises, by mass percentage, 2-10% of composition A, 1-5% of composition B, 2-6% of combination C, 0.1-0.4% of composition D, and the balance deionized water; the composition A comprises at least a fibronectin mixture; the composition B comprises at least a heteropolysaccharide; the composition C comprises at least a polyol having 3 to 6 carbon atoms; and the composition D comprises at least triethanolamine.

[0005] Preferably, the fibronectin mixture comprises fibronectin, amino acids, natural sugars, glycols, sodium chloride and water.

[0006] Preferably, the amino acid is selected from at least one of arginine, lysine, histidine, aspartic acid and serine.

[0007] Preferably, the amino acid is arginine.

[0008] Preferably, the natural sugar is selected from at least one of trehalose and β-glucan.

[0009] Preferably, the natural sugar is trehalose.

[0010] Preferably, the diol is selected from at least one of 1,2-hexanediol, 1,2-pentanediol and butanediol.

[0011] Preferably, the diols include 1,2-hexanediol and 1,2-pentanediol.

[0012] Preferably, the fibronectin mixture comprises fibronectin, trehalose, arginine, 1,2-hexanediol, 1,2-pentanediol, sodium chloride and water.

[0013] Fibronectin can accelerate cell migration, enhance metabolism, accelerate cell growth, and is beneficial to the repair of a healthy skin barrier. However, fibronectin is easily affected by ambient temperature and may aggregate. Therefore, fibronectin is mostly used in skin care in the form of freeze-dried formulations.

[0014] In order to ensure that fibronectin can be stably present in the essence, the applicant has found through extensive research that when the fibronectin mixture includes fibronectin, amino acids, natural sugars, diols, sodium chloride and water, especially when the fibronectin mixture includes fibronectin, trehalose, arginine, 1,2-hexanediol, 1,2-pentanediol, sodium chloride and water, fibronectin can be stably present in the system of this application and avoid coagulation due to the influence of ambient temperature. The applicant speculates that this is because the trehalose, arginine, 1,2-hexanediol, 1,2-pentanediol, and sodium chloride in this application interact with fibronectin through hydrogen bonds and electrostatic effects to avoid irreversible denaturation of fibronectin; at the same time, it will not affect the structure and performance of fibronectin.

[0015] Preferably, the composition A further comprises a root extract of Cynanchum otophyllum.

[0016] Preferably, the mass ratio of the fibronectin mixture to the peony root extract is (4-6):1.

[0017] Preferably, the mass ratio of the fibronectin mixture to the peony root extract is 5:1.

[0018] Preferably, the composition B further comprises polyacrylic acid, EDTA-2Na, glycerol and hydantoin derivatives.

[0019] Preferably, the heteropolysaccharide is selected from at least one of hyaluronic acid, xanthan gum and gum arabic.

[0020] Preferably, the heteropolysaccharide comprises hyaluronic acid and xanthan gum; the mass ratio is (0.05-0.2): (0.05-0.1).

[0021] Preferably, the polyacrylic acid is selected from at least one of Carbopol 940, Carbopol 941 and Carbopol 934.

[0022] Preferably, the polyacrylic acid is Carbopol 941.

[0023] Preferably, the hydantoin derivative is allantoin.

[0024] Preferably, the mass ratio of the heteropolysaccharide, polyacrylic acid, EDTA-2Na, glycerol and hydantoin derivative is (0.1-0.2):(0.1-0.3):(0.01-0.05):(2-4):(0.1-0.3).

[0025] Preferably, the mass ratio of the heteropolysaccharide, polyacrylic acid, EDTA-2Na, glycerol and hydantoin derivative is 0.18:0.25:0.03:3:0.15.

[0026] In the present application, in addition to the instability of fibronectin, the stability of the peony root extract introduced in the present application is also poor. The applicant has found that when the composition B in the present application includes heteropolysaccharides, polyacrylic acid, EDTA-2Na, glycerol, and hydantoin derivatives, and the mass ratio of heteropolysaccharides, polyacrylic acid, EDTA-2Na, glycerol, and hydantoin derivatives is controlled to be (0.1~0.2): (0.1~0.3): (0.01~0.05): (2~4): (0.1~0.3), while improving the repair performance of the essence, the occurrence of system instability is avoided. After the prepared essence has been subjected to cold and hot cycles, no abnormal phenomena such as stratification, thinning or protein precipitation occur.

[0027] Preferably, the polyol having 3 to 6 carbon atoms is at least one selected from propylene glycol, glycerol, 1,3-butanediol, 1,2-hexanediol, and 1,2-pentanediol.

[0028] Preferably, the polyol having 3 to 6 carbon atoms includes propylene glycol and 1,2-pentanediol; the mass ratio is (2 to 4):1.

[0029] Preferably, the composition C further comprises p-hydroxyacetophenone.

[0030] Preferably, the mass ratio of the polyol having 3 to 6 carbon atoms to p-hydroxyacetophenone is (3 to 5): (0.2 to 0.4).

[0031] Preferably, the composition D is triethanolamine.

[0032] The second aspect of the present invention provides a method for preparing a skin repair essence, comprising the following steps:

[0033] First, weigh each raw material by mass percentage; then dissolve composition B in deionized water, heat to dissolve and defoam, cool to 60°C after defoaming, add composition C and composition D, and adjust the pH to 6.5-7; continue to cool to 45°C, add composition A, stir evenly; finally cool to 38°C and filter with 300-mesh filter cloth to obtain the product.

[0034] Preferably, the specific method of heating and dissolving the composition B and defoaming is: firstly, dissolving the composition B in deionized water and heating it to 85°C at a speed of 25 to 35 r / min; then, homogenizing at a constant temperature for 3 minutes and then stirring and defoaming for 15 to 20 minutes; finally, cooling water is turned on and the temperature is lowered at 15 to 25 r / min.

[0035] Beneficial effects:

[0036] 1. When the fibronectin mixture in the present application includes fibronectin, amino acids, natural sugars, diols, sodium chloride and water, especially when the fibronectin mixture includes fibronectin, trehalose, arginine, 1,2-hexanediol, 1,2-pentanediol, sodium chloride and water, the fibronectin can be stably present in the present application, and no stratification, thinning or protein precipitation occurs after 30 days of hot and cold cycles.

[0037] 2. When the composition B in the present application includes heteropolysaccharides, polyacrylic acid, EDTA-2Na, glycerol, and hydantoin derivatives, and the mass ratio of heteropolysaccharides, polyacrylic acid, EDTA-2Na, glycerol, and hydantoin derivatives is controlled to be (0.1-0.2): (0.1-0.3): (0.01-0.05): (2-4): (0.1-0.3), while improving the repair performance of the essence, it also avoids the occurrence of system instability. After the prepared essence has been subjected to cold and hot cycles, no abnormal phenomena such as stratification, thinning, or protein precipitation occur.

[0038] 3. In the present application, when the polyol having 3 to 6 carbon atoms includes propylene glycol and 1,2-pentanediol, and the mass ratio is (2 to 4):1, the thermal stability of the essence can be further improved while promoting the absorption of the essence. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] Figure 1 This is a test plan for the repairing effect of the skin base repair essence prepared in Example 1.

[0040] Figure 2 These are the steps for testing the repairing effect of the skin base repairing essence prepared in Example 1.

[0041] Figure 2-1 It is the average moisture content of the skin stratum corneum.

[0042] Figure 2-2 It is the rate of change of moisture content in the stratum corneum of the skin.

[0043] Figure 3 Descriptive statistics for the moisture content of the skin stratum corneum.

[0044] Figure 4To analyze the difference in moisture content in the skin stratum corneum.

[0045] Figure 4-1 It is the mean value of transepidermal water loss (TEWL).

[0046] Figure 4-2 It is the change rate of transepidermal water loss (TEWL) value of the skin.

[0047] Figure 5 Descriptive statistics of transepidermal water loss (TEWL) values.

[0048] Figure 6 This is an analysis of the differences in transepidermal water loss (TEWL) values. DETAILED DESCRIPTION

[0049] Example 1

[0050] Example 1 provides a skin repair essence, wherein the raw materials include, by mass percentage, 6% of composition A, 3.36% of composition B, 4.3% of combination C, 0.25% of composition D, and the balance of deionized water;

[0051] The composition A comprises a fibronectin mixture and a peony root extract; the mass ratio of the fibronectin mixture to the peony root extract is 5:1.

[0052] The peony root extract was purchased from Guangdong Gexin Biotechnology Co., Ltd., model: NB-328 (INCI: water, butylene glycol, peony root extract, 1,2-hexanediol).

[0053] The fibronectin mixture includes fibronectin, amino acids, natural sugars, diols, sodium chloride and water, and is purchased from Guangdong Gexin Biotechnology Co., Ltd., model: NB-659.

[0054] The composition B comprises heteropolysaccharide, polyacrylic acid, EDTA-2Na, glycerol and hydantoin derivatives.

[0055] The mass ratio of the heteropolysaccharide, polyacrylic acid, EDTA-2Na, glycerol and hydantoin derivative is 0.18:0.25:0.03:3:0.15.

[0056] The heteropolysaccharide comprises hyaluronic acid and xanthan gum; the mass ratio is 0.1:0.08.

[0057] The polyacrylic acid is Carbopol 941.

[0058] The hydantoin derivative is allantoin.

[0059] The composition C comprises a polyol having 3 to 6 carbon atoms and p-hydroxyacetophenone.

[0060] The mass ratio of the polyol having 3 to 6 carbon atoms to p-hydroxyacetophenone is 4:0.3.

[0061] The polyol with carbon atoms of 3 to 6 includes propylene glycol and 1,2-pentanediol; the mass ratio is 3:1.

[0062] The composition D is triethanolamine.

[0063] A method for preparing a skin repair essence, comprising the following steps:

[0064] First, weigh each raw material by mass percentage; then heat and dissolve composition B, defoam, cool to 60°C, add composition C and composition D after defoaming, and adjust the pH to 6.5-7; continue to cool to 45°C, add composition A, and stir evenly; finally cool to 38°C and filter with 300-mesh filter cloth to obtain the product.

[0065] The specific method of heating, dissolving and defoaming the composition B is as follows: first, the composition B is heated to 85° C. at a rotation speed of 30 r / min; then, the composition is homogenized at a constant temperature for 3 minutes and then stirred and defoamed for 18 minutes; finally, cooling water is turned on at a temperature of 20 r / min to cool the composition.

[0066] The prepared essence was placed under cold (-15°C)-hot (45°C) cycle conditions for 30 days and then returned to room temperature without any stratification, thinning or protein precipitation.

[0067] Repair efficacy test:

[0068] Test plan see Figure 1 ; The Pronotin protein repair skin base essence in the figure refers to the skin base repair essence prepared in Example 1 of the present application.

[0069] Test steps see Figure 2 ;

[0070] Test results see Figure 2-1 , 2-2, 4-1, 4-2, Figure 3 to Figure 6 .

Claims

1. A skin repair essence, characterized in that: In terms of mass percentage, the raw materials include composition A 2-10%, composition B 1-5%, combination C 2-6%, composition D 0.1-0.4%, and the balance deionized water; The composition A at least comprises a fibronectin mixture; the composition B at least comprises a heteropolysaccharide; The composition C at least includes a polyol having 3 to 6 carbon atoms; and the composition D at least includes triethanolamine.

2. The skin repair essence according to claim 1, characterized in that: The fibronectin mixture comprises fibronectin, amino acids, natural sugars, glycols, sodium chloride and water.

3. The skin repair essence according to claim 2, characterized in that: The amino acid is selected from at least one of arginine, lysine, histidine, aspartic acid and serine.

4. The skin repair essence according to claim 3, characterized in that: The diol is selected from at least one of 1,2-hexanediol, 1,2-pentanediol and butanediol.

5. The skin repair essence according to claim 1, characterized in that: The composition A further comprises a peony root extract.

6. The skin repair essence according to claim 5, characterized in that: The mass ratio of the fibronectin mixture to the peony root extract is (4-6):

1.

7. The skin repair essence according to claim 1, characterized in that: The composition B further comprises polyacrylic acid, EDTA-2Na, glycerol and hydantoin derivatives.

8. The skin repair essence according to claim 1, characterized in that: The heteropolysaccharide is selected from at least one of hyaluronic acid, xanthan gum and gum arabic.

9. The skin repair essence according to claim 1, characterized in that: The polyol having 3 to 6 carbon atoms is at least one selected from propylene glycol, glycerol, 1,3-butanediol, 1,2-hexanediol, and 1,2-pentanediol.

10. A method for preparing the skin repair essence according to any one of claims 1 to 9, characterized in that: The following steps are involved: First, weigh each raw material by mass percentage; then dissolve composition B in deionized water, heat to dissolve and defoam, cool to 60°C after defoaming, add composition C and composition D, and adjust the pH to 6.5-7; continue to cool to 45°C, add composition A, stir evenly; finally cool to 38°C and filter with 300-mesh filter cloth to obtain the product.

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