Traditional Chinese medicine composition and extract for improving facial couperose skin as well as preparation method and application of traditional Chinese medicine composition and extract

Abstract

The invention discloses a traditional Chinese medicine composition and extract for improving facial couperose skin as well as a preparation method and application of the traditional Chinese medicine composition and extract. The traditional Chinese medicine composition is prepared from herba leonuri and corydalis serrate. The traditional Chinese medicine composition is subjected to water extraction, butanediol is selectively added, and the extract for improving the facial couperose skin is obtained. The traditional Chinese medicine composition or extract can significantly improve facial couperose skin; the traditional Chinese medicine composition has no adverse reaction, is low in cost, and provides another way for improving the facial couperose skin for users with individual differences.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for improving facial red blood streaks, an extract, and a preparation method and application thereof. Background Art

[0002] Facial red blood streaks are caused by the reduced elasticity and increased fragility of the capillary walls on the face, which leads to continuous uneven expansion or even rupture of blood vessels. In severe cases, it can also cause vascular hyperplasia, resulting in redness of the facial skin and dilated capillaries, often accompanied by red or purple-red spots, dots, lines or stars. If facial red blood streaks are not treated in time, it will not only increase the sensitivity of the skin, causing burning, itching and stinging, but also damage the skin barrier, making the skin more susceptible to external factors and free radicals, and accelerating the aging process of the skin. Long-term facial red blood streaks will also make the skin more susceptible to infection by bacteria and other pathogens, thereby causing skin inflammation and other skin diseases. This not only affects the appearance of the skin, but may also lead to inferiority, seriously affecting people's self-confidence and mental health.

[0003] At present, the means of treating red blood streaks at home and abroad are mainly physical methods such as laser treatment. Through the principle of selective photothermal decomposition, the hemoglobin in the diseased blood vessels is acted on, causing the diseased blood vessels to be thermally decomposed, absorbed, and disappear. However, laser treatment is often accompanied by pain, and improper treatment may cause edema or residual dark spots. In addition, laser treatment is expensive and is suitable for a small number of people. Topical cosmetic treatments are mainly for soothing the skin. Currently, only a few French pharmaceutical cosmetics companies have launched cosmetics for red blood streaks, but the effectiveness of these products is still affected by individual differences.

[0004] Traditional Chinese medicine has had methods of facial conditioning since ancient times. However, due to individual differences, some Chinese medicine prescriptions may cause allergies or ineffectiveness during use, so more types and attempts are needed to meet the needs of different groups of people. In traditional Chinese medicine, facial red blood streaks are regarded as "face redness" or "facial erythema", which is often related to pathological factors such as blood heat, blood stasis, and qi deficiency. Traditional Chinese medicine believes that the appearance of facial red blood streaks is caused by yin deficiency and blood heat, insufficient body fluid and blood, and stagnation of blood vessels, which leads to malnutrition of the skin and dry skin, which accelerates keratinization, thinning of the skin, and the appearance of red face. Summary of the invention

[0005] The primary purpose of the present invention is to overcome the shortcomings and deficiencies of the prior art and provide a Chinese medicine composition for improving facial red blood streaks.

[0006] Another object of the present invention is to provide an extract for improving facial red blood streaks and a preparation method thereof.

[0007] Another object of the present invention is to provide the use of the above-mentioned Chinese medicine composition or extract for improving facial red blood streaks.

[0008] The purpose of the present invention is achieved through the following technical scheme: a traditional Chinese medicine composition for improving facial red blood streaks, composed of the following ingredients by mass: 25-40 parts of motherwort and 5-15 parts of dentate corydalis.

[0009] A method for preparing an extract for improving facial redness is to extract the above-mentioned Chinese medicine composition with water; preferably comprising the following steps: (1) extracting the above-mentioned Chinese medicine composition for improving facial redness with water, separating the solid from the liquid, and taking the liquid; (2) The liquid obtained in step (1) is further clarified to obtain an extract.

[0010] In order to make the obtained extract more stable, the above preparation method further comprises the following steps: (3) Add polyol and water to the extract and mix well to obtain an extract for improving facial redness.

[0011] The water described in step (1) is preferably softened water.

[0012] The amount of water used in step (1) is 6 to 10 times the mass of the traditional Chinese medicine composition.

[0013] The extraction in step (1) is carried out at room temperature.

[0014] The room temperature refers to 10-40°C, preferably 20-30°C, and more preferably 24-26°C.

[0015] The extraction time in step (1) is preferably 0.5 to 3 hours.

[0016] The solid-liquid separation method in step (1) is preferably filtration.

[0017] The clarification method in step (2) is preferably centrifugation.

[0018] The polyol described in step (3) is preferably butanediol.

[0019] The amount of the polyol in step (3) is preferably calculated based on the mass of the polyol being 1.5 to 2.5 times the mass of the traditional Chinese medicine composition; more preferably, the mass of the polyol is calculated based on the mass of the traditional Chinese medicine composition being 1.6 to 2.2 times the mass of the traditional Chinese medicine composition.

[0020] The water described in step (3) is preferably ultrapure water.

[0021] The amount of water used in step (3) is preferably calculated based on the mass of water being 2 to 4 times the mass of the traditional Chinese medicine composition; more preferably, the amount of water is calculated based on the mass of the polyol being 2.3 to 3.5 times the mass of the traditional Chinese medicine composition.

[0022] An extract for improving facial red blood streaks is obtained by the above preparation method.

[0023] Application of the above-mentioned Chinese medicinal composition for improving facial red blood streaks or the extract for improving facial red blood streaks in the preparation of skin care products for improving facial red blood streaks.

[0024] A skin care product for improving facial red blood streaks, comprising the extract for improving facial red blood streaks; preferably comprising the following ingredients in percentage by mass: 0.05% EDTA-2Na, 0.5% silicone wax DC2501, 0.3% cinnamone, 4% hydroxyethyl urea, 0.02% sarin resin PC2000, 2% of the extract for improving facial red blood streaks, 0.3% hydroxyethyl cellulose, 0.03% sodium hyaluronate, 5% glycerol, 0.02% essence, 0.1% HPS, 1,3-propylene glycol, and 0.15% PE9010.

[0025] The skin care product for improving facial redness also contains water, which is the balance.

[0026] The method for preparing the above-mentioned skin care product for improving facial redness comprises the following steps: 1) Mix EDTA-2Na, silicone wax DC2501, cinnamaldehyde, hydroxyethyl urea, sarin resin PC2000, the extract for improving facial redness and water, and heat to 75-80°C under stirring to obtain phase A; 2) Mix hydroxyethyl cellulose, sodium hyaluronate, glycerin and essence, stir until there are no fine particles, and obtain phase B; add phase B to phase A, mix evenly, and keep warm at 75-80℃ until completely dissolved; 3) HPS, 1,3-propylene glycol and water are mixed evenly to obtain phase C; 4) The product finally obtained in step 2) is cooled to 40-42° C., phase C and PE9010 are added, stirred evenly, and filtered to obtain a skin care product for improving facial redness.

[0027] The stirring speed in step 1) is preferably 40 to 60 rpm.

[0028] The gauze used in the filtration described in step 4) is 200 mesh gauze.

[0029] Compared with the prior art, the present invention has the following advantages and effects: According to the traditional Chinese medicine concept of "promoting blood circulation and removing blood stasis, cooling blood and reducing swelling", motherwort and corydalis are combined. Among them: motherwort promotes blood circulation and removes blood stasis, cools blood and reduces swelling; corydalis dentata promotes blood circulation and removes blood stasis, promotes qi and relieves pain, and dredges blood vessels. The whole formula has the effects of promoting blood circulation and removing blood stasis, unblocking blood vessels, cooling blood and reducing swelling, and regulating red face. The Chinese medicine composition provided by the present invention can significantly improve facial red blood streaks. The Chinese medicine composition described in the present invention has no adverse reactions and low cost, and provides another way to improve facial red blood streaks for users with individual differences. DETAILED DESCRIPTION

[0030] The present invention is further described in detail below in conjunction with examples, but the embodiments of the present invention are not limited thereto.

[0031] Example 1 Weigh 32 parts by weight of Leonurus japonicus and 8 parts by weight of Corydalis serrulata, add them to softened water 8 times the weight of the total amount of the medicinal materials, soak and extract at room temperature for 1 hour, and pass through a 100-mesh filter to separate the solid and liquid. The separated liquid is centrifuged (8000 rpm) to remove most of the particles, and 80 parts by weight of butanediol and 116 parts by weight of ultrapure water are added to the liquid after centrifugation. After stirring evenly, filter through a 0.22 μm microporous filter membrane to obtain an extract for improving facial red blood streaks.

[0032] Example 2 The difference between Example 2 and Example 1 is that the ratio and extraction conditions of the Chinese medicine composition are adjusted.

[0033] Weigh 40 parts by weight of Leonurus japonicus and 15 parts by weight of Corydalis serrulata, add them to softened water 10 times the weight of the total amount of the medicinal materials, soak and extract at room temperature for 3 hours, and pass through a 100-mesh filter to separate the solid and liquid. The separated liquid is centrifuged to remove most of the particles, and 90 parts by weight of butanediol and 125 parts by weight of ultrapure water are added to the liquid after centrifugation. After stirring evenly, the extract for improving facial red blood streaks is obtained after filtering through a 0.22 μm microporous filter membrane.

[0034] Example 3 The difference between Example 3 and Example 1 is that the ratio and extraction conditions of the Chinese medicine composition are adjusted.

[0035] Weigh 25 parts by weight of Leonurus japonicus and 5 parts by weight of Corydalis serrulata, add them to softened water 6 times the weight of the total amount of the medicinal materials, soak and extract at room temperature for 0.5 hours, and separate the solid and liquid through a 100-mesh filter after the extraction. The separated liquid is centrifuged to remove most of the particles, and 65 parts by weight of butanediol and 105 parts by weight of ultrapure water are added to the liquid after centrifugation. After stirring evenly, filter through a 0.22 μm microporous filter membrane to obtain an extract for improving facial red blood streaks.

[0036] Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that the Corydalis yanhusuo was removed from the traditional Chinese medicine composition.

[0037] Weigh 40 parts by weight of Leonurus japonicus, add 8 times the weight of the demineralized water, soak and extract at room temperature for 1 hour, and pass through a 100-mesh filter to separate the solid and liquid. Centrifuge the separated liquid to remove most of the particles, add 80 parts by weight of butanediol and 116 parts by weight of ultrapure water to the liquid after centrifugation, stir evenly, and filter through a 0.22 μm microporous filter membrane to obtain an extract for improving facial red blood streaks.

[0038] Comparative Example 2 The difference between Comparative Example 2 and Example 1 is that Leonurus japonicus is removed from the traditional Chinese medicine composition.

[0039] Weigh 40 parts by weight of Corydalis dentata, add it to softened water 8 times the weight of the medicinal material, soak and extract at room temperature for 1 hour, and pass through a 100-mesh filter to separate the solid and liquid. Centrifuge the separated liquid to remove most of the particles, add 80 parts by weight of butanediol and 116 parts by weight of ultrapure water to the liquid after centrifugation, stir evenly, and filter through a 0.22 μm microporous filter membrane to obtain an extract that improves facial red blood streaks.

[0040] Comparative Example 3 The difference between Comparative Example 3 and Example 1 is that the Corydalis dentata in the traditional Chinese medicine composition is replaced with Tremella fuciformis having similar efficacy.

[0041] Weigh 32 parts by weight of Leonurus japonicus and 8 parts by weight of Tremella fuciformis, add them to 8 times the weight of softened water, soak and extract at room temperature for 1 hour, and pass through a 100-mesh filter to separate the solid and liquid. The separated liquid is centrifuged to remove most of the particles, and 80 parts by weight of butanediol and 116 parts by weight of ultrapure water are added to the liquid after centrifugation. After stirring evenly, the extract for improving facial red blood streaks is obtained after filtering through a 0.22 μm microporous filter membrane.

[0042] Test Example 1 1. Subjects Thirty female subjects with red blood streaks on their faces were selected.

[0043] 2. Inclusion criteria (1) The facial red blood streaks are distributed in the form of dots, threads or reticular patterns; (2) capillary diameter ≥ 0.1 mm; (3) Dilated capillaries ≥ 5 / cm 2 ; (4) Lesion area ≥ 3 cm × 3 cm; (5) Diffuse redness of the local skin.

[0044] Subjects who meet any one or more of the above criteria can be included.

[0045] 3. Exclusion criteria (1) Women who are breastfeeding, pregnant or planning to become pregnant; (2) Those who are currently using photosensitizing drugs; (3) Those who receive other facial treatments at the same time; (4) Those who are allergic to drugs; (5) Participants in other clinical trials within the past month.

[0046] 4. Treatment methods The extracts described in the examples and comparative examples were made into facial masks, and the facial mask formula is shown in Table 1. The subjects were divided into 6 groups using a stratified random grouping method, with 5 cases in each group. The subjects in each group applied the facial masks made from Examples 1 to 3 and Comparative Examples 1 to 3 before going to bed on Mondays, Wednesdays, and Fridays for three consecutive weeks. The subjects were photographed by a VISIA skin detector every Sunday to measure skin erythema. The lower the erythema value, the better the effect of improving facial red blood streaks.

[0047] 5. Statistical processing Measuring data SPSS 20.0 software was used for statistical analysis. Analysis of variance was used to compare the erythema index between the two groups, and P ≤ 0.05 indicated that the difference was statistically significant.

[0048] 6. Results The results in Table 2 show that the extracts provided in Examples 1 to 3 can effectively reduce the erythema index of the face, and there is a statistical difference between before and after treatment. Comparative Examples 1 and 3 can also effectively reduce the erythema index, but the effect is not as good as that of the examples. The extract provided in Comparative Example 2 cannot reduce the erythema index, and there is no statistical significance.

[0049] The above embodiments are preferred implementation modes of the present invention, but the implementation modes of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principles of the present invention should be equivalent replacement methods and are included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for improving facial red blood streaks, characterized in that The invention is composed of the following ingredients by weight: 25-40 parts of Leonurus japonicus and 5-15 parts of Corydalis dentata.

2. A method for preparing an extract for improving facial redness, characterized in that The method comprises the following steps: extracting the Chinese medicine composition according to claim 1 with water to obtain an extract for improving facial red blood streaks.

3. The method for preparing the extract for improving facial redness according to claim 2, characterized in that The steps include: (1) extracting the above-mentioned Chinese medicine composition for improving facial redness with water, separating the solid from the liquid, and taking the liquid; (2) The liquid obtained in step (1) is further clarified to obtain an extract.

4. The method for preparing the extract for improving facial redness according to claim 3, characterized in that The following steps are also included: (3) Add polyol and water to the extract and mix well to obtain an extract for improving facial redness.

5. The method for preparing the extract for improving facial redness according to claim 4, characterized in that The following steps are also included: The water described in step (1) is softened water; The amount of water used in step (1) is 6 to 10 times the mass of the Chinese medicine composition; The solid-liquid separation method in step (1) is filtration; The clarification method in step (2) is centrifugation; The polyol described in step (3) is butanediol; The amount of the polyol in step (3) is calculated based on the polyol being 1.5 to 2.5 times the mass of the traditional Chinese medicine composition; The water described in step (3) is ultrapure water; The amount of water used in step (3) is calculated based on the mass of water being 2 to 4 times the mass of the traditional Chinese medicine composition.

6. An extract for improving facial redness, characterized in that: The method is obtained by the preparation method according to any one of claims 2 to 5.

7. Use of the Chinese medicinal composition for improving facial red blood streaks according to claim 1 or the extract for improving facial red blood streaks according to claim 6 in the preparation of a skin care product for improving facial red blood streaks.

8. A skin care product for improving facial redness, characterized by: Contains the extract for improving facial redness as claimed in claim 6.

9. The skin care product for improving facial redness according to claim 8, characterized in that The invention contains the following ingredients by mass percentage: EDTA-2Na 0.05%, silicone wax DC2501 0.5%, cinnamaldehyde 0.3%, hydroxyethyl urea 4%, sarin resin PC2000 0.02%, the extract for improving facial red blood streaks according to claim 6 2%, hydroxyethyl cellulose 0.3%, sodium hyaluronate 0.03%, glycerol 5%, essence 0.02%, HPS 0.1%, 1,3-propylene glycol 1%, and PE9010 0.15%.

10. The method for preparing the skin care product for improving facial redness according to claim 9, characterized in that The steps include: 1) Mix EDTA-2Na, silicone wax DC2501, cinnamaldehyde, hydroxyethyl urea, sarin resin PC2000, the extract for improving facial redness and water, and heat to 75-80°C under stirring to obtain phase A; 2) Mix hydroxyethyl cellulose, sodium hyaluronate, glycerin and essence, stir until there are no fine particles, and obtain phase B; add phase B to phase A, mix evenly, and keep warm at 75-80℃ until completely dissolved; 3) HPS, 1,3-propylene glycol and water are mixed evenly to obtain phase C; 4) The product finally obtained in step 2) is cooled to 40-42° C., phase C and PE9010 are added, stirred evenly, and filtered to obtain a skin care product for improving facial redness.

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