Patch for treating oral ulcer and preparation method thereof

Abstract

The invention provides a patch for treating oral ulcer and a preparation method thereof, and relates to the field of traditional Chinese medicine preparation. The ginger juice is prepared from the following raw materials in parts by weight: 5-10 parts of herba asari, 0.5-3 parts of ginger juice, 1-3 parts of radix angelicae dahuricae and 1-3 parts of cassia twig, and fresh ginger is juiced and filtered to obtain ginger juice; the preparation method comprises the following steps: respectively crushing the asarum, the angelica dahurica and the cassia twig, uniformly mixing, adding the ginger juice and the auxiliary agent, and uniformly mixing. When the patch is applied to the sole, no stimulation is generated to the dental ulcer, the patient acceptability is high, and the dental ulcer does not relapse after the patch with the formula is used for treating the dental ulcer. Secondly, the patch provided by the invention can be used for quickly removing dampness in the body, improving sub-health and enhancing body immunity while treating the oral ulcer, and has the effect of building the body. According to the preparation method of the patch, all the medicinal materials only need to be smashed or juiced, operation is easy, large equipment is not needed, and the patch can be processed and prepared by a patient at home and is not limited by the environment.

Description

Technical Field

[0001] The invention relates to the field of traditional Chinese medicine pharmaceutical preparation, and in particular to a patch for treating oral ulcers and a preparation method thereof. Background Art

[0002] Oral ulcers are a common oral mucosal disease. The main symptom is the formation of small and shallow defects or ulcers on the oral mucosa, which are usually accompanied by pain, discomfort, and may affect eating and speaking. Oral ulcers may be caused by a variety of factors, including trauma, infection, immune system diseases, and reactions to certain drugs or foods.

[0003] The main purpose of oral ulcer treatment is to relieve pain, promote healing and prevent recurrence. In the field of Western medicine, the treatment method is mainly local medication, which applies anti-inflammatory analgesics, antibacterial drugs or drugs that promote healing to the ulcer. For patients with more severe symptoms, systemic medication will be used, such as immunosuppressants or vitamin supplements. Common local treatment drugs include oral sprays, ointments, and films, which can quickly relieve pain and promote ulcer healing.

[0004] In the field of traditional Chinese medicine, the treatment of oral ulcers emphasizes syndrome differentiation and treatment, and treatment is carried out according to the patient's specific symptoms. For example, for oral ulcers of the type of heart fire inflammation, Chinese medicine prescriptions often use Xiexin Decoction, Xiaoji Yinzi, etc. to clear the heart and reduce fire; for oral ulcers of the type of spleen and stomach fire, Qingwei San, Yunu Jian, etc. are often used to clear heat and reduce fire; for oral ulcers of yin deficiency and fire, nourishing yin and clearing heat are the key to treatment, and commonly used prescriptions include Liuwei Dihuang Decoction, Qiju Dihuang Decoction, etc. Commonly used external Chinese medicines include Bingpeng San, Xilei San, Yangyin Shengji San, etc. These medicines have the effects of clearing heat and detoxification, reducing swelling and relieving pain, and can be applied directly to the ulcer surface to relieve pain and promote healing.

[0005] Whether it is Western medicine or Chinese medicine, for local medication, the medicine needs to be applied to the oral ulcer. When using the medicine, it will cause irritation and pain, aggravating the patient's pain, which is not conducive to long-term treatment, especially for recurrent oral ulcers, which will increase the psychological burden of patients. Moreover, Western medicine only treats the symptoms but not the root cause, and the treatment process is slow and cannot cure the disease. Summary of the invention

[0006] The purpose of the present invention is to provide a patch for treating oral ulcers, which is directly attached to the Yongquan acupoint of the foot, does not directly apply medicine to the ulcer, does not cause irritating pain, and has high patient acceptance.

[0007] Another object of the present invention is to provide a method for preparing a patch for treating oral ulcers, which is simple and does not require large-scale mechanical equipment.

[0008] The present invention solves the technical problem by adopting the following technical solutions.

[0009] On the one hand, an embodiment of the present invention provides a patch for treating oral ulcers, which includes the following raw materials in parts by weight: 5-10 parts of asarum, 0.5-3 parts of ginger juice, 1-3 parts of angelica dahurica, and 1-3 parts of cassia twig.

[0010] Among the raw materials of this patch, Angelica dahurica can dispel wind and dampness, reduce swelling and relieve pain, and cinnamon twig can dispel cold and warm the meridians. Ginger juice has the effect of dispelling wind and cold and promoting blood circulation, and asarum can dispel cold and dampness. This formula can dispel dampness and cold, and it is applied to the Yongquan acupoint on the sole of the foot, and the purpose of treating oral ulcers is achieved by stimulating the Yongquan acupoint with drugs. Secondly, during the application process, the active ingredients of the drug can enter the body through the penetration of the skin, participate in the body circulation, and then essentially remove moisture from the body and treat oral ulcers.

[0011] Furthermore, the following raw materials are included by weight: 6 parts of asarum, 1 part of ginger juice, 1.5 parts of angelica dahurica, and 1.5 parts of cassia twig.

[0012] Furthermore, the following raw materials are included by weight: 10 parts of asarum, 3 parts of ginger juice, 3 parts of angelica dahurica, and 3 parts of cassia twig.

[0013] Furthermore, the following raw materials are included by weight: 5 parts of asarum, 0.5 parts of ginger juice, 1 part of angelica dahurica, and 1 part of cassia twig.

[0014] Preferably, the invention further comprises 1-2 parts of auxiliary agent by weight, wherein the auxiliary agent is honey or aged vinegar. Honey can be used as a binder to bond the powders together for easy application on the sole of the foot, while aged vinegar can soften the medicine for better absorption of the medicine.

[0015] On the other hand, an embodiment of the present invention provides a method for preparing a patch for treating oral ulcers, comprising the following steps:

[0016] Squeeze fresh ginger and filter to obtain ginger juice; grind asarum, angelica dahurica and cassia twig separately, mix them evenly, then add ginger juice and auxiliary agents and mix them evenly.

[0017] Furthermore, the particle size of Asarum, Angelica dahurica and Cinnamomum cassia after being crushed is 200-300um. After the raw materials are crushed, their cell walls and fiber structures are broken, the surface area is increased, and it is more conducive to the release of effective ingredients.

[0018] Compared with the prior art, the embodiments of the present invention have at least the following advantages or beneficial effects:

[0019] The composition for treating oral ulcer provided by the present invention comprises asarum, ginger juice, angelica dahurica, cassia twig, angelica dahurica dispels wind and dampness, relieves swelling and relieves pain, cassia twig relieves the symptoms and dispels cold, warms and unblocks the meridians. Ginger juice has the effects of dispelling wind and cold, promoting blood circulation, and asarum dispels cold and dampness. Oral ulcer is caused by damp and cold air in the body, and the radical cure method is mainly to dispel dampness, and the formula can dispel dampness and dispel cold. The medicine is applied to the Yongquan acupoint of the sole of the foot, and its effect is that yang goes up, the heat of the human body is led down, and the kidney yang is supplemented upward. When the kidney yang is supplemented upward, the moisture in the body is expelled from the body, and the purpose of radical cure of oral ulcer is achieved, and the effect of treating the upper disease and the lower part is achieved. The medicine is used in the sole of the foot, and no stimulation will be produced to the oral ulcer, and the patient acceptance is high. After the patch treatment of this formula, the oral ulcer does not recur.

[0020] Secondly, the patch provided by the present invention can quickly remove moisture from the body while treating oral ulcers, improve sub-health, enhance body immunity, and play a role in strengthening the body.

[0021] The patch preparation method provided by the present invention only requires crushing or juicing various medicinal materials, is simple to operate, does not require large-scale equipment, and can be processed and prepared by patients at home without being restricted by the environment. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for use in the embodiments are briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without creative work.

[0023] Figure 1 This is a physical picture of the patch of Example 1 when it is unfolded;

[0024] Figure 2 This is a physical picture of the back side of the patch of Example 1;

[0025] Figure 3 This is a physical picture of the front side of the patch of Example 1; DETAILED DESCRIPTION

[0026] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention will be described clearly and completely below. If the specific conditions are not specified in the embodiments, they are carried out according to conventional conditions or conditions recommended by the manufacturer. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased commercially.

[0027] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments may be combined with each other. The present invention will be described in detail below with reference to specific embodiments.

[0028] On the one hand, an embodiment of the present invention provides a patch for treating oral ulcers, which includes the following raw materials in parts by weight: 5-10 parts of asarum, 0.5-3 parts of ginger juice, 1-3 parts of angelica dahurica, and 1-3 parts of cassia twig.

[0029] In some embodiments of the present invention, the following raw materials are included by weight: 6 parts of asarum, 1 part of ginger juice, 1.5 parts of angelica dahurica, and 1.5 parts of cassia twig.

[0030] In some embodiments of the present invention, the following raw materials are included by weight: 10 parts of asarum, 3 parts of ginger juice, 3 parts of angelica dahurica, and 3 parts of cassia twig.

[0031] In some embodiments of the present invention, the following raw materials are included by weight: 5 parts of asarum, 0.5 parts of ginger juice, 1 part of angelica dahurica, and 1 part of cassia twig.

[0032] Asarum, pungent in nature, warm. It enters the heart, lung, and kidney meridians. It has a strong aromatic smell, pungent and warm, and can penetrate the exterior and interior, and is slightly toxic but has a strong effect. It is good at dispelling wind and cold, opening the orifices and relieving pain. It is a good medicine for treating various pains caused by wind-cold and rheumatism, as well as headaches caused by sinusitis and nasal congestion. It can warm and dispel lung cold, resolve phlegm and fluid, and is a key medicine for treating cold fluid in the lungs. It is most suitable for Shaoyin headache, sinusitis headache, and toothache. It mainly contains active ingredients such as lignin, volatile oil, and aristolochic acid I. It has the effects of dispelling cold, dispelling wind and relieving pain, opening the orifices, and warming the lungs and resolving fluid.

[0033] Angelica dahurica is pungent in nature and warm in nature. It enters the stomach, large intestine and lung meridians. Angelica dahurica is pungent, dispersing, warming and dry, aromatic and invigorating. It is good at dispersing wind and cold, removing dampness, unblocking the nasal orifices and joints, and is also good at relieving pain, releasing the exterior, stopping leukorrhea, and dispersing lumps and promoting the discharge of pus. It has strong medicinal power and is suitable for all symptoms caused by wind and cold, wind and cold with dampness, and cold and dampness. It is especially good at treating pain in the brow bone, Yangming headache, wind-cold nasal congestion or nasal sinus headache. It can treat sores and swellings. In the early stage, it can promote blood circulation and dissipate sores and swellings, and relieve the exterior symptoms; in the middle stage, it can eliminate pus before it forms, and it can ulcerate pus before it forms, and it can promote the discharge of pus after it has ulcerated; in the late stage, it can promote the growth of muscles after all pus is gone, and it should be gradually reduced. It contains volatile oil, and contains various coumarin compounds such as imperatorin and white angelicae, Angelica dahuricae toxin, Zanthoxylum toxin, sterols, stearic acid and other ingredients. It has the effects of relieving the exterior symptoms, dispersing cold, dispelling wind and relieving pain, unblocking the nasal orifices, drying dampness and stopping leukorrhea, and reducing swelling and discharging pus.

[0034] Cinnamon twig is pungent, sweet and warm in nature. It enters the heart, lung and bladder meridians. Cinnamon twig is pungent, dispersing, warming and unblocking, and sweet and warm to help yang. It warms and unblocks the body, moistens and helps the yang of the whole body, and circulates the blood of the whole body. It enters the lung and bladder meridians, and is good at dispersing wind and cold and relieving wind and cold or wind evil on the surface. It enters the heart meridian and blood, and is good at warming and unblocking yang, dispersing cold evil, unblocking blood vessels, unblocking chest yang, warming and transforming water and dampness, and relieving pain. It moves both on the surface and inside, and is suitable for all wind-cold symptoms, whether they are deficiency or excess, and for all cold symptoms, whether they are deficiency or excess, or external cold directly hits the body, or yang deficiency and endogenous. It enters both the qi and blood, and it is advisable to stop using it if there is blood stasis, cold and yang deficiency and water. It contains volatile oils, phenols, organic acids, polysaccharides, glycosides, coumarin and tannins, and has the effects of sweating and relieving muscles, warming and unblocking meridians, helping yang and transforming qi, and balancing and descending qi.

[0035] Ginger juice is juice obtained by squeezing fresh ginger, which has multiple functions and effects, such as detoxification and sterilization, and has obvious inhibitory effects on Salmonella typhi and Vibrio cholerae. Ginger juice is slightly warm in nature, can promote blood circulation, is conducive to removing the cold in the body, and can effectively prevent colds caused by exogenous cold. It also contains rich ginger ketone and shogaol components, has an antiemetic effect, and can be used for vomiting caused by motion sickness, seasickness or stomach cold. In the present invention, the added ginger juice can stimulate the Yongquan acupoint, open the pores, and promote the absorption of drugs.

[0036] In some embodiments of the present invention, 1-2 parts of auxiliary agent are also included by weight, and the auxiliary agent is honey or aged vinegar. Honey can be used as a binder to bond the powders together for easy application on the sole of the foot; and aged vinegar can soften the drug and facilitate drug absorption.

[0037] On the other hand, an embodiment of the present invention provides a method for preparing a patch for treating oral ulcers, comprising the following steps:

[0038] Squeeze fresh ginger and filter to obtain ginger juice; grind asarum, angelica dahurica and cassia twig separately, mix them evenly, then add ginger juice and auxiliary agents and mix them evenly.

[0039] It should be noted that the patch of the present invention is made on the spot and the method of use is: stick it on the Yongquan acupoints at the bottom of both feet before going to bed at night, and peel it off when getting up in the morning. The general sticking time is 8-10 hours, and the continuous sticking for 4-8 days can cure the disease. Due to the different severity of oral ulcers, the number of times of medication is also different.

[0040] In some embodiments of the present invention, the particle size of Asarum, Angelica dahurica and Cinnamomum cassia after crushing is 200-300um.

[0041] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0042] Example 1

[0043] Prepare the raw materials according to the following ratio:

[0044] 6 parts of asarum, 1 part of ginger juice, 1.5 parts of angelica dahurica, 1.5 parts of cassia twig, and 1 part of honey.

[0045] Prepare the patch of this example as follows:

[0046] Squeeze fresh ginger and filter to obtain ginger juice; grind asarum, angelica dahurica and cassia twig respectively to an average particle size of 200um, mix the powders of each raw material evenly, then add ginger juice and honey, stir and mix evenly, take a clean gauze, take about 10g of the medicine and apply it on the gauze.

[0047] Example 2

[0048] Prepare the raw materials according to the following ratio:

[0049] 6 parts of asarum, 1 part of ginger juice, 1.5 parts of angelica dahurica, 1.5 parts of cassia twig, and 1 part of honey.

[0050] Prepare the patch of this example as follows:

[0051] Squeeze fresh ginger and filter to get ginger juice; grind Asarum, Angelica dahurica and Cinnamon twig to an average particle size of 200um respectively, mix the raw material powders evenly, add ginger juice and honey, stir and mix evenly, take a clean gauze, take about 10g of the medicine and apply it on the gauze. Figure 1-3 shown.

[0052] Example 3

[0053] Prepare the raw materials according to the following ratio:

[0054] 10 parts of asarum, 3 parts of ginger juice, 3 parts of angelica dahurica, 3 parts of cassia twig, and 2 parts of honey.

[0055] Prepare the patch of this example as follows:

[0056] Squeeze fresh ginger and filter to obtain ginger juice; grind asarum, angelica dahurica and cassia twig respectively to an average particle size of 200um, mix the powders of each raw material evenly, then add ginger juice and honey, stir and mix evenly, take a clean gauze, take about 10g of the medicine and apply it on the gauze.

[0057] Example 4

[0058] Prepare the raw materials according to the following ratio:

[0059] 6 parts of asarum, 1 part of ginger juice, 1.5 parts of angelica dahurica, 1.5 parts of cassia twig, and 1 part of aged vinegar.

[0060] Prepare the patch of this example as follows:

[0061] Squeeze fresh ginger and filter to obtain ginger juice; grind asarum, angelica dahurica and cassia twig respectively to an average particle size of 300um, mix the powders of each raw material evenly, then add ginger juice and honey, stir and mix evenly, take a clean gauze, take about 10g of the medicine and apply it on the gauze.

[0062] Example 5

[0063] Prepare the raw materials according to the following ratio:

[0064] 8 parts of asarum, 3 parts of ginger juice, 1 part of angelica dahurica, 3 parts of cassia twig, and 1 part of aged vinegar.

[0065] Prepare the patch of this example as follows:

[0066] Squeeze fresh ginger and filter to obtain ginger juice; grind asarum, angelica dahurica and cassia twig respectively to an average particle size of 300um, mix the powders of each raw material evenly, then add ginger juice and honey, stir and mix evenly, take a clean gauze, take about 10g of the medicine and apply it on the gauze.

[0067] Example 6

[0068] Prepare the raw materials according to the following ratio:

[0069] 10 parts of asarum, 3 parts of ginger juice, 3 parts of angelica dahurica, 1 part of cinnamon twig, and 1 part of aged vinegar.

[0070] Prepare the patch of this example as follows:

[0071] Squeeze fresh ginger and filter to obtain ginger juice; grind asarum, angelica dahurica and cassia twig respectively to an average particle size of 300um, mix the powders of each raw material evenly, then add ginger juice and honey, stir and mix evenly, take a clean gauze, take about 10g of the medicine and apply it on the gauze.

[0072] Typical Cases

[0073] Duan, male, 13 years old, oral ulcer recurred about once every two or three months. He took medicine and sprays to treat the symptoms but not the root cause. After applying the patch of Example 1 for 5 days, the oral ulcer was cured and there was no recurrence within half a year of follow-up.

[0074] Hua, female, 32 years old, had recurrent oral ulcers for more than 3 years. Western medicine treatment, medication, injections, infusions, etc., had no obvious effect and a high recurrence rate. After applying the patch of Example 1 for 4 days, the pain disappeared. After continuing to apply for 8 days, the oral ulcers were cured. During the follow-up of 1 year, there was no recurrence of oral ulcers.

[0075] Liu, male, 60 years old, due to the increasing age and the decline of body resistance, oral ulcers recurred every 1-2 months, and the course of disease was more than 2 years. After applying the patch of Example 1 for 8 days, the oral ulcers were cured. During the follow-up of half a year, there was no recurrence of oral ulcers.

[0076] Peng, female, 35 years old, intermittent recurrent oral ulcer, the course of disease lasted more than 10 years, and each recurrence lasted more than 10 days. After applying the patch of Example 1 for 8 days, it was cured. Follow up a case by regular visits to within half a year, recurred once, and then continued to apply a course of treatment, recovered, and followed up a case by regular visits to within 1 year without recurrence.

[0077] In summary, the composition for treating oral ulcer provided by the present invention comprises asarum, ginger juice, angelica dahurica, and cassia twig, angelica dahurica dispels wind and dampness, relieves swelling and relieves pain, and cassia twig relieves the symptoms and dispels cold, warms and dredges the meridians. Ginger juice has the effects of dispelling wind and cold and promoting blood circulation, and asarum dispels cold and dampness. The formula can dispel dampness and cold, and achieves the purpose of treating oral ulcer by stimulating Yongquan acupoint. The medicine is used on the sole of the foot, and will not stimulate the oral ulcer. The patient acceptance is high, and after the patch treatment of this formula, the oral ulcer does not recur.

[0078] Secondly, the patch provided by the present invention can quickly remove moisture from the body while treating oral ulcers, improve sub-health, enhance body immunity, and play a role in strengthening the body.

[0079] The patch preparation method provided by the present invention only requires crushing or juicing various medicinal materials, is simple to operate, does not require large-scale equipment, and can be processed and prepared by patients at home without being restricted by the environment.

[0080] The embodiments described above are part of the embodiments of the present invention, rather than all of the embodiments. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

Claims

1. A patch for treating oral ulcers, It is characterized in that The following raw materials are included by weight: 5-10 parts of asarum, 0.5-3 parts of ginger juice, 1-3 parts of angelica dahurica, and 1-3 parts of cassia twig.

2. The patch for treating oral ulcer according to claim 1, It is characterized in that The preparation method comprises the following raw materials by weight: 6 parts of asarum, 1 part of ginger juice, 1.5 parts of angelica dahurica and 1.5 parts of cassia twig.

3. The patch for treating oral ulcer according to claim 1, It is characterized in that The following raw materials are included by weight: 10 parts of asarum, 3 parts of ginger juice, 3 parts of angelica dahurica, and 3 parts of cassia twig.

4. The patch for treating oral ulcer according to claim 1, It is characterized in that The preparation method comprises the following raw materials by weight: 5 parts of asarum, 0.5 parts of ginger juice, 1 part of angelica dahurica and 1 part of cassia twig.

5. A patch for treating oral ulcers according to any one of claims 1 to 4, It is characterized in that The invention also comprises 1-2 parts of auxiliary agent by weight, and the auxiliary agent is honey or aged vinegar.

6. A method for preparing a patch for treating oral ulcers as claimed in any one of claim 6, It is characterized in that The following steps are involved: Squeeze fresh ginger and filter to obtain ginger juice; grind asarum, angelica dahurica and cassia twig separately, mix them evenly, then add ginger juice and auxiliary agents and mix them evenly.

7. A method for preparing a patch for treating oral ulcers according to claim 6, It is characterized in that The particle size after crushing is 200-300um.

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