Traditional Chinese medicine ointment formula for treating myotonia of Parkinson's disease

Abstract

The invention relates to a traditional Chinese medicine ointment rubbing prescription for treating myotonia caused by Parkinson's disease, belonging to the field of traditional Chinese medicine preparations, the prescription is composed of raw tortoise shell, raw turtle shell, white peony root, arisaema cum bile, semen brassicae, ground beetle, corydalis tuber and other traditional Chinese medicines, the traditional Chinese medicine components except musk are decocted into thick ointment with wine, and then the thick ointment is mixed with musk to prepare the traditional Chinese medicine ointment rubbing prescription. The traditional Chinese medicine ointment massage therapy is combined, the medicine is promoted to directly reach the disease site through skin striae and interstices in a traditional Chinese medicine transdermal mode, the effects of relaxing tendons and activating collaterals, dispersing blood stasis and relieving pain, and dispelling cold and eliminating dampness are achieved, and the good treatment effect is achieved for patients suffering from myotonia caused by the Parkinson's disease. Meanwhile, muscle biomechanical characteristics of patients suffering from the myotonia of the Parkinson's disease are quantitatively monitored, the patients are treated by traditional Chinese medicine featured therapy traditional Chinese medicine ointment massage, the muscle biomechanical characteristics of the patients are evaluated, the treatment effect of the traditional Chinese medicine ointment massage on the patients is researched, and therefore a clinical basis is provided for objective evaluation and standardized treatment of the myotonia of the Parkinson's disease; and the kit has very important clinical significance for improving the life quality of a patient and evaluating prognosis.

Description

Technical Field

[0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine ointment formula for treating Parkinson's disease myotonia. Background Art

[0002] Parkinson's disease (PD) is a common neurodegenerative disease in the middle-aged and elderly. The main pathological changes of PD are the degeneration, necrosis and loss of dopamine (DA) neurons in the substantia nigra of the midbrain and the formation of Lewy bodies composed of α-synuclein. Its etiology and pathogenesis have not yet been fully elucidated. Clinically, it is mainly characterized by resting tremor, bradykinesia, muscle rigidity and postural balance disorders. Although PD does not cause life-threatening danger, it seriously affects the patient's daily life and work. The development of the disease is worrying and may even lead to paralysis. Therefore, relevant clinical research on PD is of great practical significance.

[0003] Myotonia refers to increased muscle tension in a quiet and relaxed state. It is the main motor symptom of PD patients and one of its clinical diagnostic criteria. The degree of myotonia is verified clinically by the size of joint resistance during passive movement. The characteristic of myotonia in Parkinson's disease or other Parkinson's syndromes is that the size of joint resistance during passive movement is consistent and has little to do with the speed of passive movement. Some patients have increased muscle tension accompanied by a gear-like sense of frustration, which is different from muscle spasms caused by pyramidal tract damage. Myotonia of the limbs, trunk, and neck muscles can cause patients to have a special flexed posture, manifested as head forward, trunk flexion, elbow flexion, wrist extension, forearm adduction, and slight bending of the hip and knee joints. Myotonia is one of the main symptoms that affect patients' daily life and work. At present, the treatment of PD myotonia patients mainly adopts dopamine replacement and symptomatic treatment. The treatment effect varies from person to person, the overall treatment effect is not good, and the corresponding prognosis is also poor.

[0004] In addition, since there are currently no objective evaluation indicators for the above symptoms of PD myotonia in clinical practice, it is entirely up to experienced physicians to determine the condition based on clinical history and careful physical examination. This can easily lead to misdiagnosis and mistreatment, which can have a certain impact on the patient's prognosis. Summary of the invention

[0005] The technical problem to be solved by the present invention is to provide a Chinese medicine ointment formula for treating Parkinson's disease myotonia. The ointment formula is combined with traditional Chinese medicine ointment therapy to promote the drug to pass through the skin pores and reach the diseased area directly through the transdermal method of traditional Chinese medicine. It has the effects of relaxing muscles and tendons, removing blood stasis and relieving pain, and dispelling cold and dampness. It has a good therapeutic effect on patients with Parkinson's disease myotonia.

[0006] In order to achieve the above object, the technical solution adopted by the present invention is:

[0007] A Chinese medicinal ointment formula for treating Parkinson's disease myotonia is composed of the following Chinese medicinal raw materials by weight:

[0008] Raw tortoise shell 40-80g, raw turtle shell 40-80g, white peony root 40-80g, Arisaema cinerea 20-40g, white mustard seed 20-40g, earthworm 20-40g, Corydalis 40-80g, Photinia serrulata 20-40g, Asarum 10-25g, dried ginger 20-30g, Phellodendron chinense 20-30g, musk 10-20g; add wine to the Chinese medicinal ingredients except musk and boil them into a thick paste, and then mix with musk to make a Chinese medicinal ointment formula.

[0009] Chinese medicine ointment massage belongs to the external treatment of traditional Chinese medicine. It is a kind of external treatment method that combines medicine and massage techniques. It promotes the drug to reach the diseased area through the skin pores through local transdermal means, and has the effects of relaxing muscles and activating collaterals, removing blood stasis and relieving pain, and dispelling cold and dampness. Based on the Xin'an medical theory, in view of the pathological characteristics of phlegm and blood stasis entering the collaterals in patients with PD myotonia, Wang Meixia, chief physician of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, advocates that the treatment should nourish yin and soften muscles, remove phlegm and remove blood stasis, and relieve pain, warm the meridians and dredge the collaterals; based on many years of clinical experience, the Chinese medicine ointment massage formula is formulated, and the formula uses raw tortoise shell, raw turtle shell, and white peony as the main ingredients. Raw tortoise shell and raw turtle shell nourish yin and suppress yang, stop wind and stop spasm, white peony is sour and astringent, nourishes blood and softens the liver and promotes the circulation of vital energy, and together they play the effect of nourishing yin and softening muscles. Arisaema bile and white mustard seeds resolve phlegm; earthworm removes blood stasis, and together they play the effect of resolving phlegm and removing blood stasis, and they are all ministerial drugs. Yanhusuo promotes blood circulation, qi and relieves pain; Photinia serrulata dispels wind and cold and dredges the meridians; Asarum and dried ginger warm and dredge the tendons, and Herba Astragali removes blood and dredges the menstruation, and are all adjuvants. Musk is pungent and warm, with a very fragrant smell and a very strong nature. It promotes blood circulation, dredges the menstruation, relieves swelling and relieves pain. It has good permeability and can directly reach the diseased area, so it is an adjuvant. The above drugs can be used together to achieve good clinical treatment effects.

[0010] As a preferred technical solution of the present invention, the Chinese medicine ointment formula is composed of the following Chinese medicine raw materials by weight:

[0011] 60g raw tortoise shell, 60g raw turtle shell, 50g white peony root, 30g Arisaema consanguineum, 30g white mustard seed, 30g earthworm, 60g Corydalis yanhusuo, 35g Photinia serrulata, 10g Asarum, 30g dried ginger, 20g Phellodendron chinense, and 10g musk.

[0012] The digital muscle function assessment system can quantify muscle parameters, truly and objectively reflect the functional state of the muscle, and can evaluate the metabolic process. The digital muscle function assessment system is to use a light touch probe to slightly impact the muscle, causing the muscle to vibrate, and the acceleration sensor to record the mechanical vibration of the muscle. Then, through software calculation, it can provide biomechanical characteristic parameters such as vibration frequency F (reflecting muscle tension), logarithmic attenuation value D of amplitude (reflecting muscle elasticity), dynamic muscle hardness S, mechanical pressure release time R, and the ratio of relaxation time to deformation time C (Deborah number). These quantitative parameters truly and objectively reflect the functional state of the muscle and can evaluate the metabolic process.

[0013] The present invention uses a digital muscle assessment system to quantitatively detect the biomechanical properties of muscles in patients with dystonia due to phlegm and blood stasis syndrome of brain-type hepatolenticular degeneration, observe the levels of biomechanical properties (F, S, D, R, C) of muscles (biceps brachii, triceps brachii, biceps femoris, quadriceps femoris, gastrocnemius, extensor digitorum longus) of patients with Parkinson's disease myotonia and normal people, and unify the Parkinson's rating scale (UPDRSⅢ) score and UPDRS myotonia score. In this way, the influence of traditional Chinese medicine ointment massage on the biomechanical properties of muscles in patients with Parkinson's disease myotonia is explored, so as to compare and evaluate the clinical efficacy of the traditional Chinese medicine ointment massage. It is confirmed by experiments that:

[0014] 1. Compared with the normal group, the muscle biomechanical properties of patients with Parkinson's disease myotonia were different to varying degrees. The levels of F and S of the measured muscles were significantly higher than those of the normal group (P<0.01); the level of R was significantly lower than that of the normal group (P<0.01); the levels of D and C were not clinically significant compared with the normal group (P>0.05). It can be seen that the quantitative detection of F, S, and R by the digital muscle assessment system can reflect the changes in the muscle biomechanical properties of patients with Parkinson's disease myotonia, while D and C cannot represent the muscle biomechanical properties of this type of patients.

[0015] 2. After 4 weeks of treatment, the levels of F, S, and R of the biceps brachii, triceps brachii, biceps femoris, and quadriceps femoris of the treatment group were more significantly improved than those of the control group (P<0.01); the comparison of D and C had no clinical significance (P>0.05); the biomechanical properties of the gastrocnemius (lateral) and extensor digitorum longus (F, S, D, R, C) had no clinical significance when the two groups were compared (P>0.05).

[0016] 3. Before treatment, there was no significant difference in the Unified Parkinson's Disease Rating Scale (UPDRSⅢ) score and UPDRS myotonia score between the control group and the treatment group (P>0.05); after treatment, the comparison within the two groups was better than before treatment (P<0.01), and compared with the control group, the treatment group was better than the control group, and the difference was statistically significant (P<0.01). Therefore, Chinese medicine paste can improve the muscle biomechanical properties, Unified Parkinson's Disease Rating Scale (UPDRSⅢ) score, and UPDRS myotonia score of patients with Parkinson's disease myotonia, and has good safety and clinical efficacy.

[0017] Therefore, the Chinese medicine ointment massage formula proposed by the present invention can be used to treat Parkinson's disease myotonia and has a good therapeutic effect. At the same time, the present invention applies digital muscle function assessment to the muscles of patients with Parkinson's disease myotonia, conducts quantitative monitoring of muscle biomechanical properties, and gives Chinese medicine ointment massage treatment with Chinese medicine characteristics, evaluates the muscle biomechanical properties of patients with the disease, and studies the therapeutic effect of Chinese medicine ointment massage on them, thereby providing a clinical basis for the objective evaluation and standardized treatment of myotonia of this disease, which has very important clinical significance for improving the quality of life of patients and evaluating prognosis. DETAILED DESCRIPTION

[0018] To explore the effect of traditional Chinese medicine ointment massage on the biomechanical properties of muscles in patients with Parkinson's disease myotonia, so as to compare and evaluate the clinical efficacy of the traditional Chinese medicine ointment massage.

[0019] 1 Information

[0020] 1.1 General Information

[0021] A total of 60 cases of Parkinson's disease myotonia that met the inclusion criteria were patients who were admitted to the Brain Disease Center of the First Affiliated Hospital of Anhui University of Chinese Medicine for regular treatment between June 2023 and June 2024. They were randomly divided into two groups, as the treatment group and the control group, with 30 people in each group.

[0022] The 30 subjects in the normal group were all from the Physical Examination Center of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine.

[0023] 1.2 Diagnostic criteria

[0024] Western medicine diagnostic criteria for Parkinson's disease: Developed with reference to the Diagnostic Criteria for Parkinson's Disease in China (2016 Edition), the core criteria for Parkinson's disease are: bradykinesia and at least one of resting tremor or muscle rigidity. The diagnosis can be made according to the following criteria: (1) There are no absolute exclusion criteria; (2) At least 2 supporting criteria; (3) There are no warning signs.

[0025] 1.3 Case inclusion criteria:

[0026] (1) Meet the Western medical diagnostic criteria for PD;

[0027] (2) Meet the clinical classification criteria for PD;

[0028] (4) Age 50 to 79 years (inclusive);

[0029] (5) Patients with the first diagnosis who had not been treated with dopamine or other drugs within 2 months before enrollment;

[0030] (6) Patients confirmed to have myotonia by careful specialist examination by two attending physicians or above;

[0031] (7) The patient or family member signs the informed consent form.

[0032] 1.4 Case Exclusion Criteria:

[0033] (1) Patients who do not meet the Western medical diagnostic criteria for PD;

[0034] (2) younger than 50 years old or older than 79 years old;

[0035] (3) Patients who have used drugs that regulate or (and) affect muscle tone;

[0036] (4) Patients with severe dystonia that affects their normal life;

[0037] (5) Combination with other diseases that are proven to be unrelated to PD and have clear etiologies that may affect bones and muscles, such as craniocerebral trauma, infection, high fever, etc.;

[0038] (6) Patients with comorbid anxiety and depression;

[0039] (7) Those with severe heart, liver, or kidney dysfunction;

[0040] (8) Others who the researcher believes are unable to complete the trial.

[0041] 1.5 Case dropout and exclusion criteria:

[0042] (1) Patients who cannot continue treatment due to intolerance to Chinese medicine;

[0043] (2) Patients and their families voluntarily request to withdraw from clinical research;

[0044] (3) Patients who are found to have other serious diseases during treatment;

[0045] (4) Patients who were found not to strictly follow the treatment plan or who used other methods to interfere with the test results during the study.

[0046] 2 Methods

[0047] 2.1 Treatment methods

[0048] Control group: The control group was given dopamine replacement therapy, using dopamine tablets (Shanghai Roche Pharmaceuticals Co., Ltd., national medicine standard number SH10930198, product batch number SH5893. Specification: 250 mg / tablet, including 200 mg of levodopa and 50 mg of benserazide). 3 times a day, 0.0625 g each time (taken 30 minutes before meals), for a total of 4 weeks.

[0049] Treatment group: Chinese medicine ointment massage treatment. The Chinese medicine prescription is as follows: 60g of raw tortoise shell, 60g of raw turtle shell, 50g of white peony root, 30g of gall bladder arisaema, 30g of white mustard, 30g of earthworm, 60g of corydalis, 35g of strychnine, 10g of asarum, 30g of dried ginger, 20g of ghost arrow feather, and 10g of musk. The specific operation method is as follows: 1) Add 52-degree white wine to the remaining Chinese medicines except musk to make a thick paste, and then mix with musk to obtain the Chinese medicine ointment massage formula. 2) The patient lies flat on the bed and rubs the exposed affected area (i.e. the muscle corresponding to dystonia) with a cloth dipped in ointment for 20-30 minutes. 3) Treatment is twice a week for a total of 4 weeks.

[0050] 2.2 How to operate the digital muscle assessment system

[0051] ① Measurement position and measurement point selection of biceps brachii (bilateral): Have the subject lie on his back on the treatment bed, relax his upper limbs, keep his forearms in neutral position, and extend his elbow joints (if he cannot fully extend his forearms due to muscle spasms, support both sides of his forearms to keep them in neutral position). Tell the patient to relax as much as possible, and place the quantitative test end of the intelligent digital muscle detector MyotonPRO perpendicular to the skin surface. The measurement point of the biceps brachii is at the midpoint of the line connecting the medial humeral condyle and the acromion.

[0052] ② Selection of measurement position and measurement point for triceps brachii: Have the subject lie prone on the treatment bed, relax the upper limbs, keep the forearms in neutral position, and extend the elbow joints (if the forearms cannot be fully extended due to muscle spasms, support both sides of the forearms to keep the forearms in neutral position). Inform the patient to relax as much as possible, and place the quantitative test end of the intelligent digital muscle detector MyotonPRO perpendicular to the skin surface. The measurement point of the triceps brachii is at the midpoint of the line connecting the olecranon and the acromion.

[0053] ③Biceps femoris measurement position and measurement point selection: Ask the subject to lie prone on the treatment bed, with both hands placed naturally on the sides of the body, palms facing up. Place a semicircular pillow under the tibia, and place the feet outside the edge of the bed, without touching the edge of the bed. Tell the patient to relax as much as possible, and the quantitative test end of the intelligent digital muscle detector MyotonPRO is placed perpendicular to the skin surface. The measurement point of the biceps femoris is at the midpoint of the line connecting the lower end of the sciatic bone and the popliteal fossa.

[0054] ④ Measurement position and measurement point selection of quadriceps femoris (rectus femoris): Ask the subject to lie on his back on the treatment bed, with both hands placed naturally on the sides of the body, palms facing up. Both toes facing up, soles of the feet approximately perpendicular to the ground, and the body in a naturally relaxed state. Inform the patient to relax as much as possible, and the quantitative test end of the intelligent digital muscle detector MyotonPRO is placed perpendicular to the skin surface. The measurement point of the quadriceps femoris is at the midpoint of the line connecting the anterior superior iliac spine and the upper edge of the patella.

[0055] ⑤ Measurement position and measurement point selection of gastrocnemius (lateral): Ask the subject to lie prone on the treatment bed, with both hands placed naturally on the sides of the body, palms facing up, lower limbs naturally straight, and feet hanging outside the bed. Tell the patient to relax as much as possible, and the quantitative test end of the intelligent digital muscle detector MyotonPRO is placed perpendicular to the skin surface. The measurement point of the gastrocnemius (lateral) is marked at the middle and upper 1 / 3 of the line connecting the fibular head and the calcaneal tuberosity.

[0056] ⑥ Selection of measurement position and measurement point of the long extensor digitorum muscle: Have the subject lie on his back on the treatment bed, with both hands placed naturally on the sides of the body, palms facing up. The toes are facing up, the soles of the feet are approximately perpendicular to the ground, and the body is naturally relaxed. Tell the patient to relax as much as possible, and the quantitative test end of the intelligent digital muscle detector MyotonPRO is placed perpendicular to the skin surface. The measurement point of the long extensor digitorum muscle is at the midpoint of the line connecting the lower end of the patella and the tip of the lateral malleolus.

[0057] 2.3 Observation indicators

[0058] 2.3.1 Muscle biomechanical characteristic indicators

[0059] The levels of biomechanical properties (F, S, D, R, C) of muscles in the normal group and the diseased group before treatment (treatment group, control group) (biceps brachii, triceps brachii, biceps femoris, quadriceps femoris, gastrocnemius, extensor digitorum longus) were measured.

[0060] The levels of biomechanical properties (F, S, D, R, C) of muscles (biceps brachii, triceps brachii, biceps femoris, quadriceps femoris, gastrocnemius, and extensor digitorum longus) in the treatment group and the control group were measured after treatment.

[0061] 2.3.2 Scale indicators

[0062] The changes of Unified Parkinson's Disease Rating Scale (UPDRSⅢ) scores and UPDRS myotonia scores were observed in the treatment group and the control group before and after treatment.

[0063] 2.4 Statistical methods

[0064] All data were analyzed using SPSS 23.0 statistical software. Measurement data were expressed as mean ± standard deviation (±s). The t test was used for two groups of measurement data that met normal distribution, and the rank sum test was used for non-normal distribution. Variance analysis was used for comparison between multiple groups of measurement data, and chi-square test was used for counting data. When the statistical results showed that P>0.05 was not statistically significant, P<0.05 was different, and P<0.01 was significantly different.

[0065] 3 Results

[0066] 3.1 Biomechanical characteristic indicators:

[0067] Table 1 Changes in biomechanical characteristics of biceps brachii in patients with PD myotonia

[0068]

[0069] Note: Compared with the normal group, * P<0.01.

[0070] Table 2 Changes in biomechanical characteristic indices of biceps brachii in the two groups

[0071]

[0072] Note: Compared with before treatment, * P<0.01; compared with the control group, # P<0.01.

[0073] Table 3 Changes in biomechanical characteristics of triceps brachii in patients with PD myotonia

[0074]

[0075] Note: Compared with the normal group, * P<0.01.

[0076] Table 4 Changes in biomechanical characteristic indices of triceps brachii in the two groups

[0077]

[0078] Note: Compared with before treatment, * P<0.01; compared with the control group, # P<0.01.

[0079] Table 5 Changes in biomechanical characteristics of biceps femoris in patients with PD myotonia

[0080]

[0081] Note: Compared with the normal group, * P<0.01.

[0082] Table 6 Changes in biomechanical characteristic indices of biceps femoris in two groups

[0083]

[0084] Note: Compared with before treatment, * P<0.05; compared with the control group, # P<0.05.

[0085] Table 7 Changes in biomechanical characteristics of quadriceps femoris in patients with PD myotonia

[0086]

[0087] Note: Compared with the normal group, * P<0.01.

[0088] Table 8 Changes in biomechanical characteristic indices of quadriceps femoris in two groups

[0089]

[0090]

[0091] Note: Compared with before treatment, * P<0.01; compared with the control group, # P<0.01.

[0092] Table 9 Changes in biomechanical characteristics of gastrocnemius muscle in patients with PD myotonia

[0093]

[0094] Note: Compared with the normal group, * P<0.01.

[0095] Table 10 Changes in biomechanical characteristic indices of gastrocnemius muscle in the two groups

[0096]

[0097] Note: Compared with before treatment, * P<0.01.

[0098] Table 11 Changes in biomechanical characteristics of the extensor digitorum longus muscle in patients with PD myotonia

[0099]

[0100] Note: Compared with before treatment, * P<0.01.

[0101] Table 12 Changes in biomechanical characteristic indices of the extensor digitorum longus muscle in the two groups

[0102]

[0103] Note: Compared with before treatment, * P<0.01.

[0104] From Table 1-12 we can see that:

[0105] ①Compared with the normal group, before treatment, the F and S indexes of the biceps brachii, triceps brachii, biceps femoris, quadriceps femoris, gastrocnemius and extensor digitorum longus of the treatment group and the control group were significantly increased (P<0.01); the R index was significantly decreased (P<0.01); there was no significant change in the D and C indexes, and the difference was not statistically significant (P>0.05).

[0106] ②After 4 weeks of treatment, compared with the control group, the F and S indexes of the biceps, triceps, biceps femoris and quadriceps in the treatment group were more significantly decreased than those in the control group (P<0.01); the R index increased more significantly than that in the control group (P<0.01); the D and C indexes were not statistically significant compared with those in the control group (P>0.05); while the F, S, R, D and C indexes of the gastrocnemius (lateral) and extensor digitorum longus in the treatment group were not statistically significant compared with those in the control group (P>0.05). This shows that conventional treatment with dopamine tablets and treatment with Chinese medicine ointment massage have different degrees of improvement effects on the patient's muscle biomechanical properties. The improvement effect of Chinese medicine ointment massage on the muscle biomechanical properties of the biceps, triceps, biceps femoris and quadriceps is significantly better than conventional treatment with dopamine tablets. In the treatment of the gastrocnemius muscle and the extensor digitorum longus muscle, the therapeutic effect of the Chinese medicine ointment massage treatment method adopted by the present invention is similar to that of the conventional treatment method of dopamine tablets.

[0107] 3.2 Unified Parkinson's disease rating scale (UPDRSⅢ) score:

[0108] Table 13 Changes in Unified Parkinson's Disease Rating Scale (UPDRSⅢ) scores between the two groups

[0109]

[0110] Note: Compared with before treatment, * P<0.01; compared with the control group, # P<0.01.

[0111] Compared with before treatment, the Unified Parkinson's Disease Rating Scale (UPDRSⅢ) scores of the treatment group and the control group decreased significantly (P<0.01); after treatment, the Unified Parkinson's Disease Rating Scale (UPDRSⅢ) scores of the treatment group decreased more significantly than those of the control group (P<0.01). This shows that the Chinese medicine ointment treatment can effectively reduce the movement disorder of patients with Parkinson's disease myotonia.

[0112] 3.3UPDRS muscle rigidity score:

[0113] Table 14 Changes in UPDRS myotonia scores between the two groups

[0114]

[0115] Note: Compared with before treatment, * P<0.01; compared with the control group, # P<0.01.

[0116] Compared with before treatment, the UPDRS myotonia scores of both the treatment group and the control group decreased significantly (P<0.01); after treatment, the UPDRS myotonia scores of the treatment group decreased more significantly than those of the control group (P<0.01). This indicates that the Chinese medicine Gaomo special treatment tablets can effectively improve the muscle tension of patients with Parkinson's disease myotonia.

[0117] In summary, the Chinese medicine ointment massage formula proposed in the present invention, combined with the Chinese medicine ointment massage, a characteristic therapy of traditional Chinese medicine, can be used to treat the myotonia symptoms of Parkinson's patients, and has a good therapeutic effect. At the same time, the present invention applies digital muscle function assessment to the muscles of patients with Parkinson's myotonia, conducts quantitative monitoring of muscle biomechanical properties, evaluates the biomechanical properties of the muscles of patients with the disease, and studies the therapeutic effect of Chinese medicine ointment massage on them, thereby providing a clinical basis for the objective evaluation and standardized treatment of myotonia of this disease, which has very important clinical significance for improving the quality of life of patients and evaluating prognosis.

[0118] The above contents are merely examples and explanations of the concept of the present invention. The technicians in this technical field may make various modifications or additions to the specific embodiments described or replace them in a similar manner. As long as they do not deviate from the concept of the invention or exceed the scope defined by the claims, they should all fall within the protection scope of the present invention.

Claims

1. A Chinese medicine ointment for treating Parkinson's disease myotonia, characterized in that: The Chinese medicine ointment formula is composed of the following Chinese medicine raw materials by weight: Raw tortoise shell 40-80g, raw turtle shell 40-80g, white peony root 40-80g, arisaema cinerea 20-40g, white mustard seed 20-40g, earthworm 20-40g, yanhusuo 40-80g, strychnos nux vomica 20-40g, asarum 10-25g, dried ginger 20-30g, euphorbia obesa 20-30g, musk 10-20g; The Chinese medicinal ingredients except musk are boiled with wine into a thick paste, which is then mixed with musk to make a Chinese medicinal ointment formula.

2. The Chinese medicine ointment prescription as claimed in claim 1, characterized in that: The Chinese medicine ointment formula is composed of the following Chinese medicine raw materials by weight: 60g raw tortoise shell, 60g raw turtle shell, 50g white peony root, 30g Arisaema consanguineum, 30g white mustard seed, 30g earthworm, 60g Corydalis yanhusuo, 35g Photinia serrulata, 10g Asarum, 30g dried ginger, 20g Phellodendron chinense, and 10g musk.

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