Antihypertensive traditional Chinese medicine prescription and application thereof

Abstract

The invention discloses an antihypertensive traditional Chinese medicine prescription and application thereof, and provides a traditional Chinese medicine prescription which comprises uncaria, rhizoma alismatis, ligusticum wallichii, semen raphani, seaweed and lumbricus. The invention also provides a preparation method of the traditional Chinese medicine prescription, an application of the traditional Chinese medicine prescription in preparation of hypertension medicines and an application of the traditional Chinese medicine prescription in preparation of a medicine composition for treating hypertension syndrome of phlegm and blood stasis. The invention further provides application of the preparation method in a system or equipment for automatically producing the traditional Chinese medicine prescription.

Description

Technical Field

[0001] The invention belongs to the field of biotechnology and relates to a blood pressure reducing Chinese medicinal prescription and application thereof. Background Art

[0002] Hypertension is a chronic condition in which blood pressure remains high. Blood pressure is the force exerted on the walls of the arteries when the heart contracts to pump blood into the arteries. We need to maintain normal blood pressure to move blood around the body and deliver oxygen and nutrients to all tissues. However, if blood pressure rises and remains high, it may lead to serious health problems, including stroke, coronary heart disease and heart failure, chronic kidney disease and even premature death.

[0003] However, hypertension is a complex disease caused by the combined effects of genetic factors and acquired environmental factors. Chemical drugs mainly target a certain link in the pathological changes during the development of hypertension, and their action pathways and targets are relatively single. Although they can quickly lower blood pressure, blood pressure management is complex and cannot take into account the improvement of hypertension complications. TCM treats hypertension through syndrome differentiation, adjusts the body's yin and yang balance and qi and blood deficiency and excess, corrects body dysfunction, and treats hypertension from multiple components, multiple links, and multiple targets. Summary of the invention

[0004] In order to make up for the deficiencies of the prior art, the object of the present invention is to provide a Chinese medicine prescription, which can treat, prevent or relieve hypertension.

[0005] The invention provides a traditional Chinese medicine prescription for treating hypertension. The traditional Chinese medicine prescription contains the following raw materials: Uncaria rhynchophylla, orientalis rhizome, ligusticum chuanxiong, radish seed, seaweed and earthworm.

[0006] Furthermore, the Chinese medicine prescription contains the following raw materials in the following weight ratio: 30 parts of Uncaria rhynchophylla, 10 parts of Alisma orientalis, 10 parts of Ligusticum chuanxiong, 10 parts of Radish Seed, 10 parts of Sargassum, and 10 parts of Pheretima.

[0007] Furthermore, the Chinese medicine prescription is a preparation prepared from the powder of the raw material medicine, or the water or organic solvent extract of the raw material medicine as the active ingredient, and the addition of pharmaceutically acceptable excipients; Furthermore, the Chinese medicine prescription is an oral prescription; Furthermore, the oral prescription is a solution, granules, paste, tablet, pill or capsule; Further, the auxiliary materials include adhesives, surfactants, flavoring agents, osmotic pressure regulators, antimicrobial agents, stabilizers, and / or solubilizers; In some embodiments, the Chinese medicine formula is mixed with at least one inert pharmaceutically acceptable excipient or carrier (such as sodium citrate or dicalcium phosphate) and / or a) fillers or extenders (such as starch, lactose, sucrose, glucose, mannitol and silicic acid), b) binders (such as, for example, carboxymethyl cellulose, alginates, gelatin, polyvinyl pyrrolidone, sucrose and acacia), c) humectants (such as glycerol), d) disintegrants (such as agar, calcium carbonate, potato or tapioca starch, alginic acid, certain silicates and sodium carbonate), e) solution retarder (such as paraffin), f) absorption promoters (such as quaternary ammonium compounds), g) wetting agents (such as, for example, cetyl alcohol and glyceryl monostearate, h) absorbents such as kaolin and bentonite, and i) lubricants such as talc, calcium stearate, magnesium stearate, solid polyethylene glycol, sodium lauryl sulfate and mixtures thereof. Tablets may be uncoated or may be coated by known techniques, including microencapsulation to mask unpleasant tastes or to delay disintegration and adsorption in the gastrointestinal tract, thereby providing sustained action over a longer period of time. For example, a time delay material such as glyceryl monostearate or glyceryl distearate, alone or with a wax, may be used. A water-soluble taste masking material such as hydroxypropyl methylcellulose or hydroxypropyl cellulose may be used.

[0008] Furthermore, the raw materials in the Chinese medicine prescription can be effective ingredients extracted from Uncaria rhynchophylla, Rhizoma Alismatis, Rhizoma Chuanxiong, Semen Raphani, seaweed, and Pheretima, or pharmaceutically acceptable salts of the effective ingredients; In some embodiments, the active ingredient refers to a substance obtained by extracting any form of the Chinese medicinal material (including Chinese medicinal material slices, Chinese medicinal material powder, such as Chinese medicinal material micronized powder) with a suitable pharmaceutically acceptable solvent such as water or alcohol-water solution, including specific active ingredients and mixtures containing active ingredients, which are suitable for the rehabilitation of patients in the recovery period of major diseases, effectively preventing, treating or alleviating sequelae or complications of infectious diseases, or promoting the functional recovery of damaged tissues, organs or systems caused by infectious diseases. The form of the active ingredient includes, but is not limited to, solid, semi-solid, solution, suspension, concentrate, paste and powder. The water suitable for extracting Chinese medicinal materials to obtain active ingredients in the present invention includes various waters that can be used to prepare active extracts of Chinese medicines, such as medicinal water, such as distilled water and deionized water.

[0009] In some embodiments, the pharmaceutically acceptable salt refers to a salt prepared from a pharmaceutically acceptable non-toxic base (including inorganic bases and organic bases). Salts derived from inorganic bases include aluminum salts, ammonium salts, calcium salts, copper salts, iron salts, ferrous salts, lithium salts, magnesium salts, manganic salts, manganous salts, potassium salts, sodium salts, zinc salts, etc. Specific embodiments include calcium salts, magnesium salts, zinc salts, cesium salts, potassium salts and sodium salts and salts of organic amines. Salts derived from pharmaceutically acceptable organic non-toxic amines include salts of primary, secondary, and tertiary amines, substituted amines (including naturally occurring substituted amines), cyclic amines, and basic ion exchange resins, such as arginine, betaine, caffeine, choline, N,N-dibenzylethylenediamine, diethylamine, 2-diethylaminoethanol, 2-dimethylaminoethanol, ethanolamine, ethylenediamine, N-ethylmorpholine, N-ethylpiperidine, glucosamine, glucosamine, histidine, hydrabamine, isopropylamine, lysine, methylglucamine, morpholine, piperazine, piperidine, polyamine resins, procaine, purines, theobromine, triethylamine, trimethylamine tripropylamine, tromethamine, leucine, isoleucine, methionine, alanine, meglumine, and the like.

[0010] Further, the pharmaceutically acceptable salt can also comprise the hydrate of the pharmaceutically acceptable salt of the active ingredient of the present invention. The salt of exemplification includes but is not limited to sulfate, citrate, acetate, oxalate, chloride, hydrochloride, bromide, hydrobromide, iodide, nitrate, bisulfate, phosphate, acid phosphate, isonicotinate, lactate, salicylate, acid citrate, tartrate, oleate, tannate, pantothenate, bitartrate, ascorbate, gentisinate, gluconate, glucuronate, saccharate, formate, benzoate, glutamate, methanesulfonate, ethanesulfonate, benzenesulfonate, p-toluenesulfonate, camphorsulfonate, naphthysulfonate, propionate, succinate, fumarate, maleate, malonate, mandelate, malate, palmitate, aspartate, phthalate and pamoate. Preferred pharmaceutically acceptable salts of Compound Ia include succinate, acetate, methanesulfonate, maleate, fumarate, tartrate, citrate, benzenesulfonate, L-aspartate, R-(-)-mandelate, sulfate or palmitate; and each of the above-mentioned salts may be anhydrous or hydrated.

[0011] Furthermore, the Chinese medicine prescription is administered sublingually, nasally, orally, by inhalation spray, parenterally, or by an implanted drug storage device; In some embodiments, the Chinese medicine formulation is administered systemically or topically, such as orally (e.g., using capsules, powders, solutions, suspensions, tablets, sublingual tablets, etc.), by inhalation (e.g., using aerosols, gases, inhalers, sprays, etc.), to the ears (e.g., using ear drops), topically (e.g., using creams, gels, liniments, lotions, ointments, pastes, transdermal patches, etc.), to the eyes (e.g., using eye drops, eye gels, eye ointments), rectally (e.g., using enemas or suppositories), nasally, buccally, vaginally (e.g., using douches, intrauterine devices, vaginal suppositories, vaginal rings or tablets, etc.), through implanted reservoirs, etc., or parenterally, depending on the severity and type of the disease being treated.

[0012] Furthermore, the Chinese medicine prescription can be a pharmaceutical composition, a food composition or a health care product composition.

[0013] The present invention provides a method for preparing the aforementioned Chinese medicine prescription, comprising the following steps: Weigh the raw materials according to the ratio of the Chinese medicine prescription; grind the raw materials into powder, or extract the raw materials with water or organic solvent, and add the auxiliary materials or auxiliary ingredients commonly used in medicines to obtain the product.

[0014] The present invention provides the use of the above-mentioned traditional Chinese medicine prescription in preparing a drug for treating hypertension; Furthermore, the hypertension includes essential hypertension.

[0015] As used herein, the terms "hypertension", "arterial hypertension" or "high blood pressure (HBP)" are used interchangeably and refer to an extremely common and highly preventable chronic condition in which the blood pressure (BP) in the arteries is higher than normal or desired. If not properly controlled, it represents a significant risk factor for several serious cardiovascular and renal conditions. High blood pressure can be a primary disease, known as "primary hypertension" or "essential hypertension", or it can be caused by or associated with other diseases, in which case it is classified as "secondary hypertension". Primary hypertension accounts for 90-95% of all cases.

[0016] In some embodiments, the conditions associated with the hypertension are: acute and chronic coronary hypertension; arterial hypertension; vascular conditions caused by cardiac and renal complications; vascular conditions caused by heart disease, stroke, cerebral ischemia or renal failure; resistant hypertension; diabetic hypertension; essential hypertension; secondary hypertension; gestational hypertension; preeclampsia; portal hypertension; myocardial infarction; heart failure, HFPEF, HFREF; acute and chronic HF.

[0017] Furthermore, the drug can significantly reduce the blood pressure of hypertension; In some embodiments, the blood pressure of the hypertension refers to the constriction of the blood vessels, the narrowing of the blood vessels due to muscle contraction. Vasoconstriction is a mechanism by which the body regulates and maintains mean arterial pressure (MAP). Systemic vasoconstriction usually leads to an increase in systemic blood pressure, but it may also occur in specific tissues, resulting in a local reduction in blood flow. In some embodiments, the drug can reduce the diastolic blood pressure of hypertension, which is the widening of the blood vessels. It is caused by the relaxation of smooth muscle cells in the walls of blood vessels, especially in large veins, large arteries and smaller arterioles. In essence, this process is the opposite of "vasoconstriction", which is the narrowing of blood vessels. When blood vessels dilate, the flow of blood increases due to the reduction of vascular resistance. Therefore, the expansion of arterial vessels (mainly arterioles) reduces blood pressure. The reaction can be intrinsic (due to local processes in the surrounding tissues) or extrinsic (due to hormones or the nervous system). In addition, the reaction can be localized to a specific organ (depending on the metabolic needs of a specific tissue, such as during strenuous exercise), or it can be systemic (seen throughout the body circulation).

[0018] Furthermore, the drug can regulate the physiological functions of the body in hypertension, including not causing liver and kidney damage; Further, the drug has dosage requirements, and the specific dosage requirements are the dosage of the Chinese medicine prescription according to any one of claims 1 to 3: individual body weight = 80 g: 70 kg; Furthermore, the drug is administered once every 12 hours, and 112 consecutive administrations constitute a course of treatment.

[0019] As used herein, the term "course of treatment" refers to the period of time during which a drug is administered to a patient, including any breaks from administration or recovery periods. A course of treatment may include a single treatment cycle or multiple treatment cycles. Additionally, a course of treatment may include partial treatment cycles. A course of treatment may include the total period of time during which a patient is undergoing a treatment regimen for a disease.

[0020] In certain specific embodiments, the suitable dosage of the drug can be prescribed in a variety of ways according to factors such as the formulation method, administration method, patient's age, weight, sex, morbidity, diet, administration time, administration route, excretion rate and reaction sensitivity. A skilled doctor can usually easily determine the prescription and the dosage effective for the desired treatment or prevention. The therapeutically effective amount and specific treatment regimen for a certain object (such as a mammal: a human) may be affected by many factors, including the pharmacodynamic activity of the drug used, the age, weight, general condition, sex, diet, administration time, disease susceptibility, disease progression and the judgment of the treating physician, etc. In addition, it is clear to those skilled in the art that the administration method, dosage form and dosage of the drug are affected by many factors such as the patient's age, weight, sex, morbidity, diet, administration time, excretion rate and reaction sensitivity. Therefore, the administration method, dosage form and dosage of the drug described in the present invention are not limited to the administration method, dosage form and dosage described in the embodiments of the present invention.

[0021] The present invention provides a method for preparing the aforementioned Chinese medicine prescription, comprising the following steps: Step 1: Weigh Rhizoma Alismatis, Rhizoma Chuanxiong, Radish Seed, Seaweed and Pheretima according to the proportion, add cold water to soak for one hour, and add water in an amount that the water surface exceeds the medicine surface by 5-7 cm; weigh Uncaria rhynchophylla according to the proportion, add cold water to soak for one hour, and add water in an amount that the water surface exceeds the medicine surface by 5-7 cm; Step 2, boil Rhizoma Alismatis, Rhizoma Chuanxiong, Semen Raphani, Seaweed, and Pheretima over high heat, then simmer over low heat for 20 minutes, pour half of the Uncaria rhynchophylla with water into the mixture, boil, and the resulting medicinal liquid is the first decoction product, and the filtrate residue is retained; Step 3: add cold water to the residue in step 2 and boil over high heat, then turn to low heat and simmer for 20 minutes, pour the remaining half of the Uncaria rhynchophylla with water and medicine into the mixture, boil, and the resulting medicinal liquid is the second decoction product; Step 4: the first decoction product and the second decoction product are mixed and divided into two equal parts, concentrated into a thick paste, and the thick paste is prepared into honey pills or capsules to obtain the final product.

[0022] The term "cool water" used in the present invention refers to water that has not been heated and has a water temperature of 20°C-25°C. In some embodiments, cool water refers to water at the natural temperature in most indoor environments.

[0023] The term "high fire" used in the present invention refers to using the maximum firepower of a conventional stove, with the flame covering the bottom of the pot, the firepower being strong, and the water in the pot being quickly heated to boiling.

[0024] The term "low fire" used in the present invention refers to a smaller fire of a stove, with a smaller flame and a mild fire, which can continuously decoct the medicine and avoid burning.

[0025] The present invention provides the use of the aforementioned traditional Chinese medicine prescription in preparing a pharmaceutical composition for treating or relieving hypertension phlegm and blood stasis syndrome; Further, the pharmaceutical composition includes pharmaceutically acceptable excipients; Furthermore, the auxiliary materials include adhesives, surfactants, flavoring agents, osmotic pressure regulators, antibacterial agents, stabilizers, and / or solubilizers.

[0026] The term "pharmaceutically acceptable excipient" used in the present invention means any excipient conventionally used in the field of pharmaceutical preparations, as long as the excipient does not produce adverse reactions or influences on the expected quality and efficacy of the traditional Chinese medicine prescription of the present invention.

[0027] Pharmaceutically acceptable excipients that can be used in the Chinese medicine preparation of the present invention include any excipient commonly used in Chinese medicine preparations, as long as the excipient does not adversely affect the quality, performance and therapeutic effect of the Chinese medicine preparation of the present invention. Excipients commonly used in Chinese medicine preparations include diluents, carriers, fillers, adhesives, wetting agents, disintegrants, absorption promoters, surfactants, adsorption carriers and lubricants, etc. Commonly used diluents mainly include sucrose, dextrin, starch, lactose, mannitol, xylitol, bifidus, etc. Commonly used wetting agents mainly include water, ethanol of different concentrations, etc.; commonly used adhesives include polymer adhesives, which are very diverse, such as ethyl cellulose, polyvinyl pyrrolidone, sodium carboxymethyl cellulose, polyethylene glycol, sodium alginate, etc. Commonly used disintegrants include microcrystalline cellulose, sodium carboxymethyl starch, etc. Those skilled in the art can select and determine the excipients suitable for the Chinese medicine preparation of the present invention based on the contents disclosed in this specification. The selection of a specific excipient will depend on the mode of administration or the type and state of the disease used to treat a specific patient.

[0028] The present invention provides application of the two preparation methods mentioned above in a system or equipment for automatically producing the Chinese medicine prescription mentioned above.

[0029] The present invention provides a system or device, the system or device comprising the two preparation methods described above; Further, the system or device includes a processor and a memory; Further, the memory is used to store a computer program for executing operations, and the computer program includes a computer program for executing the two preparation methods described above; Furthermore, the processor is used to execute a computer program.

[0030] The term "device" in the present invention is not limited to one or a specific number of physical objects. As used herein, a device can be any medical or electronic device with multiple components that can implement at least some parts of the present disclosure. Although the following description and examples use the term "device" to describe certain aspects of the present disclosure, the term "device" is not limited to a specific configuration, type, or number of objects.

[0031] The term "processor" or "memory" in the present invention includes a computing device with one processor or one memory and a device with multiple processors or multiple memories that can be used to perform some or all of the steps. A "processor" may include more than one processor, for example, a multi-core design or multiple processors each having a multi-core design.

[0032] As used herein, the term "computer program" or "software" is intended to include any sequence or human or machine recognizable steps for performing a function. Such a program may be presented in virtually any programming language or environment, including, for example, C / C++. ++ , Fortran, COBOL, PASCAL, assembly language, markup languages ​​(e.g., HTML, SGML, XML, VoXML), etc., and object-oriented environments such as Common Object Request Broker Architecture (CORBA), Java™ (including J2ME, Java Beans, etc.), Register Transfer Language (RTL), VHSIC (Very High Speed ​​Integrated Circuit) Hardware Description Language (VHDL), Verilog, etc.

[0033] The term "parts by weight" used in the present invention is synonymous with "parts by weight" and refers to any fixed weight expressed in milligrams, grams or kilograms (such as 1 mg, 1 g, 2 g or 1 kg, etc.). For example, a composition consisting of 1 part by weight of component a and 9 parts by weight of component b can be a composition consisting of 1 gram of component a + 9 grams of component b, or 10 grams of component a + 90 grams of component b, etc. In the composition, the percentage content of a component = (parts by weight of the component / sum of the parts by weight of all components) × 100%. Therefore, in a composition consisting of 1 part by weight of component a and 9 parts by weight of component b, the content of component a is 10%, and the content of component b is 90%.

[0034] The properties, flavors, meridians and effects of the Chinese medicinal materials used in the present invention are as follows: Uncaria rhynch0phylla, also known as double-hook vine, eagle claw wind, hanging wind root, golden hook grass, and upside-down thorn, is the dried hooked stems and branches of the Rubiaceae plants Uncaria rhynch0phylla (Miq.) Jacks., Uncaria macrophylla Wall., Uncaria hirsuta Havil., Uncaria sinensis (Oliv.) Havil., or Uncaria sessilifructus Roxb. It is harvested in autumn and winter, leaves removed, cut into sections, and dried in the sun. The stems and branches of this product are cylindrical or quasi-square columnar, 2 to 3 cm long and 0.2 to 0.5 cm in diameter. The surface is reddish brown to purple-red with fine longitudinal lines, smooth and hairless, and yellow-green to gray-brown with white dot-shaped lenticels and covered with yellow-brown soft hairs. Most branches have two hooks (sterile peduncles) that bend downwards, or only one side has hooks, and the other side has raised scars; the hooks are slightly flat or slightly round, with a sharp tip and a wide base; the branches at the base of the hooks have pit-like marks and ring-shaped stipule marks after the petiole falls off. Tough texture, yellow-brown cross section, fibrous cortex, yellow-white or hollow medulla. Odorless, light taste. Enters the liver and pericardium meridians. Sweet and cool in nature. Functions and indications: clearing heat and calming the liver, calming wind and calming convulsions. Used for headaches and dizziness, colds with convulsions, convulsions, eclampsia during pregnancy, and hypertension.

[0035] Alisma orientalis (Sam.) Juzep., also known as water ze, Ruyi flower, car bitter vegetable, swan egg, Tianbalu, Yizhihua, is a dried tuber of Alisma orientalis (Sam.) Juzep. of the Alismataceae family. It is dug up in winter when the stems and leaves begin to wither, washed, dried, and the fibrous roots and rough skin are removed. This product is spherical, elliptical or oval, 2 to 7 cm long and 2 to 6 cm in diameter. The surface is yellowish white or light yellow brown, with irregular transverse annular shallow grooves and many small protruding fibrous root marks, and some have tumor-like bud marks at the bottom. It is solid, with a yellowish white cross section, powdery, and many pores. It has a slight smell and a slightly bitter taste. It enters the kidney and bladder meridians. It is sweet and cold in nature. Functions and indications: It promotes urination and clears dampness and heat. It is used for urinary difficulty, edema, diarrhea, oliguria, phlegm and dizziness, hot stranguria and pain; and hyperlipidemia.

[0036] Chuanxiong, also known as chuanxiong and small-leaf chuanxiong, is the dried rhizome of the plant chuanxiong Ligusticum chuanxiong Hort. (or Ligusticum wallichii Franch.) of the Umbelliferae family. It is dug up in summer when the nodes on the stem are prominent and slightly purple, and the sand is removed. After drying in the sun, the fibrous roots are removed. This product is an irregular nodular fist-shaped mass with a diameter of 2 to 7 cm. The surface is yellow-brown, rough and wrinkled, with many parallel raised whorls, a concave quasi-circular stem scar on the top, and many small tubercle-like root scars on the lower side and the whorl. It is solid and not easy to break. The cross section is yellow-white or gray-yellow, with scattered yellow-brown oil chambers, and the formation layer is wavy ring pattern. It has a strong aroma, bitter and spicy taste. It has a slight numbness of the tongue and a slight sweet aftertaste. It enters the liver, gallbladder, and pericardium meridians. It is spicy and warm in nature. Functions and indications: promoting blood circulation and qi, dispelling wind and relieving pain. It is used for irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain due to masses, stabbing pain in the chest and flanks, swelling and pain from falls, headache, and rheumatic pain.

[0037] Radish seeds, also known as radish seeds, are the dried mature seeds of the cruciferous plant Raphanus sativus L. The plants are harvested in summer when the fruits are ripe, dried in the sun, the seeds are rubbed out, impurities are removed, and then dried in the sun. This product is quasi-ovate or elliptical, slightly flat, 2.5-4mm long and 2-3mm wide. The surface is yellow-brown, reddish-brown or gray-brown. There is a dark brown round hilum at one end and several longitudinal grooves on one side. The seed coat is thin and brittle, with 2 cotyledons, yellow-white and oily. Odorless, light, slightly bitter and pungent. It enters the lung, spleen and stomach meridians. The nature and flavor are pungent, sweet and flat. Functions and indications: digestion and distension, descending qi and resolving phlegm. It is used for food stagnation, abdominal distension and pain, constipation, stagnation of stool, diarrhea, phlegm and cough.

[0038] This product is the dried algae of Sargassum pallidum (Turn.) C. Ag. or Sargassum fusiforme (Harv.) Setch. of the Sargassum family. The former is commonly known as "big leaf seaweed" and the latter is commonly known as "small leaf seaweed". It is harvested in summer and autumn, and the impurities are removed, washed and dried. Big leaf seaweed: wrinkled and curled, dark brown, some covered with white frost, 30 to 60 cm long. The main trunk is cylindrical with conical protrusions, the main branches grow from both sides of the main trunk, and the side branches grow from the axils of the branches and leaves, with short thorn-like protrusions. The primary leaves are lanceolate or obovate, 5 to 7 cm long, about 1 cm wide, entire or with coarse serrations; the secondary leaves are linear or lanceolate, with small branches with linear leaves between the leaf axils. The air sacs are dark brown, spherical or oval, some with petioles, blunt tops, and some with thin short tips. It is brittle, soft when moist; it swells after soaking in water, becomes fleshy and slimy. It has a fishy smell and a slightly salty taste. It enters the liver, stomach and kidney meridians. It is bitter, salty and cold in nature. It softens and dissipates lumps, eliminates phlegm and promotes diuresis. It is used for goiter, scrofula, testicular swelling and pain, and edema caused by phlegm and fluid retention.

[0039] Earthworms are also known as earthworms, earthworms, earthworms, and redworms. This product is the dried body of the giant earthworms Pheretimaaspergillum (E. Perrier), common earthworms Pheretima vulgaris Chen, William earthworms Pheretima guillelmi (Michaelsen) or comb blind earthworms Pheretima pectinifera Michaelsen. The former is commonly known as "Guangdilong" and the latter three are commonly known as "Shanghaidilong". Guangdilong is caught from spring to autumn, and Shanghaidilong is caught in summer. The abdomen is cut open in time, the internal organs and mud and sand are removed, washed, and dried in the sun or at low temperature. Guangdilong: It is a long thin sheet, curved, with slightly curled edges, 15 to 20 cm long and 1 to 2 cm wide. The whole body has segments, the back is brown to purple-gray, and the abdomen is light yellow-brown; the 14th to 16th segments are the reproductive belt, commonly known as "white neck", which is brighter. The front end of the body is slightly pointed, the tail end is blunt and round, the bristle circle is rough and hard, and the color is slightly lighter. The male genital pore is on a small hole protruding from the ventral bristle circle of the 18th segment, with several shallow skin folds surrounding the outer edge, the inner bristle circle is raised, and there are horizontal rows (one or two rows) of small papillae on the front two sides, ranging from 10 to 20 on each side. There are two pairs of spermatocyst holes, located on an elliptical protrusion between the 7 / 8 and 8 / 9 segments, accounting for about 5 / 11 of the segmental circumference. The body is light, slightly leathery, and not easy to break. It has a fishy smell and a slightly salty taste. It enters the liver, spleen, and bladder meridians. The nature and flavor are salty and cold. Functions and indications: clearing away heat and calming the nerves, unblocking the meridians, calming asthma, and diuresis. It is used for high fever and coma, convulsions due to epilepsy, joint pain, numbness of limbs, hemiplegia, asthma and cough due to lung heat, and oliguria and edema. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] Figure 1 These are the results of HE staining of the liver and kidney of rats after taking the antihypertensive decoction, among which A is the HE staining of the liver of the blank control group; B is the HE staining of the liver of the rats after taking the medicine; C is the HE staining of the kidney of the blank control group; D is the HE staining of the kidney of the rats after taking the medicine.

[0041] Figure 2 It is a schematic diagram of a system or device prepared according to the method for preparing a blood pressure-lowering Chinese medicine prescription of the present invention. DETAILED DESCRIPTION

[0042] The present invention can be further described by the following examples, however, the scope of the present invention is not limited to the following examples. It will be appreciated by those skilled in the art that various changes and modifications may be made to the present invention without departing from the spirit and scope of the present invention. The present invention provides general and / or specific descriptions of the materials and test methods used in the test. Although many materials and operating methods used to achieve the purpose of the present invention are well known in the art, the present invention is still described in as much detail as possible herein. The following examples further illustrate the present invention, rather than limiting the present invention.

[0043] Unless otherwise indicated, all numbers used in this specification and claims to indicate volume, weight, temperature, time, density, weight parts, technical effects, etc. should be understood as modified by the term "about" or "approximately" in any case. Therefore, unless otherwise indicated, the numerical parameters listed in the following specification and the attached claims are approximate values.

[0044] Example 1

[0045] 1. Experimental methods Twenty 8-week-old male spontaneously hypertensive (SHR) rats were randomly divided into a model group and an intervention group (Jiangyetang intervention group) according to the random number table method. Ten 8-week-old male WKY rats were set as the control group. After one week of adaptive feeding, the intervention group was gavaged with the same concentration of human decoction at a volume of 10 mL kg-1 per day for 8 consecutive weeks. The control group and the model group were gavaged with the same volume of distilled water, and the systolic pressure (SBP) of the rats was measured regularly every week. After 8 weeks of gavage, samples were collected and the pathological changes of the liver and kidney tissues of the rats were observed by HE staining.

[0046] 2. Experimental results Compared with the model group, the antihypertensive decoction could significantly reduce the systolic blood pressure of SHR rats (p<0.05) (as shown in Table 1), and had no obvious damage to the liver and kidney tissues.

[0047] Table 1

[0048] Example 2

[0049] A blood pressure lowering experiment was conducted on humans using a comparative formula (original formula: radish seeds, oriental water plantain, ligusticum chuanxiong, leech), and the experimental results were compared with the blood pressure lowering ratio of the Chinese herbal formula of the present invention (improved formula: Uncaria rhynchophylla, oriental water plantain, ligusticum chuanxiong, radish seeds, seaweed, and earthworm). The results are shown in Table 2. The results show that the blood pressure lowering efficiency of the Chinese herbal formula of the present invention is significantly enhanced compared with the original formula (p<0.05).

[0050] Table 2

[0051] The description of the above embodiments is only used to understand the method and core idea of ​​the present invention. It should be pointed out that, for those skilled in the art, several improvements and modifications can be made to the present invention without departing from the principle of the present invention, and these improvements and modifications will also fall within the scope of protection of the claims of the present invention.

Claims

1. A traditional Chinese medicine prescription for treating hypertension, comprising the following raw materials: Uncaria rhynchophylla, orientalis rhizome, ligusticum chuanxiong, radish seed, seaweed, and earthworm.

2. The Chinese medicinal prescription as claimed in claim 1, which is prepared by containing the following raw materials in the following weight ratio: 30 parts of Uncaria rhynchophylla, 10 parts of Alisma orientalis, 10 parts of Ligusticum chuanxiong, 10 parts of Radish Seed, 10 parts of Sargassum, and 10 parts of Pheretima.

3. The Chinese medicine prescription according to claim 1, wherein the Chinese medicine prescription is a preparation prepared by using the powder of the raw material drug, or the water or organic solvent extract of the raw material drug as the active ingredient, and adding pharmaceutically acceptable excipients; Preferably, the Chinese medicine prescription is an oral prescription; Preferably, the oral prescription is a solution, granules, paste, tablet, pill or capsule; Preferably, the auxiliary materials include a binder, a surfactant, a flavoring agent, an osmotic pressure regulator, an antibacterial agent, a stabilizer, and / or a solubilizer; Preferably, the raw materials in the Chinese medicine prescription can be active ingredients extracted from Uncaria rhynchophylla, Rhizoma Alismatis, Rhizoma Chuanxiong, Semen Raphani, seaweed, and Pheretima, or pharmaceutically acceptable salts of the active ingredients; Preferably, the Chinese medicine prescription is administered sublingually, nasally, orally, by inhalation spray, parenterally, or by an implanted drug storage device; Preferably, the Chinese medicine prescription can be a pharmaceutical composition, a food composition or a health care product composition.

4. The method for preparing the Chinese medicine prescription according to any one of claims 1 to 3, comprising the following steps: Weigh the raw materials according to the ratio of the Chinese medicine prescription; grind the raw materials into powder, or extract the raw materials with water or organic solvent, and add the auxiliary materials or auxiliary ingredients commonly used in medicines to obtain the product.

5. Use of the Chinese medicinal formula according to any one of claims 1 to 3 in the preparation of a drug for treating hypertension; Preferably, the hypertension comprises essential hypertension.

6. The use according to claim 5, wherein the drug can significantly reduce the blood pressure of hypertension; Preferably, the drug can regulate the physiological functions of the body in hypertension, including not causing liver and kidney damage; Preferably, the drug has a dosage requirement, and the specific dosage requirement is the dosage of the Chinese medicine prescription according to any one of claims 1 to 3: individual body weight = 80 g: 70 kg; Preferably, the drug is administered once every 12 hours, and 112 consecutive administrations constitute a course of treatment.

7. A method for preparing the Chinese medicine prescription according to any one of claims 1 to 3, comprising the following steps: Step 1: Weigh Rhizoma Alismatis, Rhizoma Chuanxiong, Radish Seed, Seaweed and Pheretima according to the proportion, add cold water to soak for one hour, and add water in an amount that the water surface exceeds the medicine surface by 5-7 cm; weigh Uncaria rhynchophylla according to the proportion, add cold water to soak for one hour, and add water in an amount that the water surface exceeds the medicine surface by 5-7 cm; Step 2, boil the rhizome of orientalis, rhizome of chuanxiong, seed of radish, seaweed and earthworm over high heat, then simmer over low heat for 20 minutes, pour half of the rhizome of uncaria into the mixture with water, boil, and the resulting medicinal liquid is the first decoction product, and the residue is retained; Step 3: add cold water to the residue in step 2 and boil over high heat, then simmer over low heat for 20 minutes, pour the remaining half of the Uncaria rhynchophylla into the mixture with water and medicine, and boil. The resulting medicinal liquid is the second decoction product; Step 4: the first decoction product and the second decoction product are mixed and divided into two equal parts, concentrated into a thick paste, and the thick paste is prepared into honey pills or capsules to obtain the final product.

8. Use of the Chinese medicinal formula according to any one of claims 1 to 3 in the preparation of a pharmaceutical composition for treating or relieving hypertension with phlegm and blood stasis syndrome; Preferably, the pharmaceutical composition comprises a pharmaceutically acceptable excipient; Preferably, the auxiliary materials include a binder, a surfactant, a flavoring agent, an osmotic pressure regulator, an antibacterial agent, a stabilizer, and / or a solubilizer.

9. Use of the preparation method according to claim 4 or the preparation method according to claim 7 in a system or device for automatically producing the traditional Chinese medicine prescription according to any one of claims 1 to 3.

10. A system or device, comprising the preparation method according to claim 4 or the preparation method according to claim 7; Preferably, the system or device comprises a processor and a memory; Preferably, the memory is used to store a computer program for performing operations, and the computer program includes a computer program for performing the preparation method according to claim 4 or the preparation method according to claim 7; Preferably, the processor is configured to execute a computer program.

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