Compound lithospermum silicone gel for treating burns and scalds
The compound lithospermum silicone gel, combining lithospermum oil and silicone with herbal ingredients, addresses the limitations of existing scar treatments by enhancing wound repair and preventing scarring, achieving faster healing and improved tissue regeneration.
Patent Information
- Application Number
- CN202411481505.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-23
- Publication Date
- 2024-12-17
AI Technical Summary
Existing silicone preparations for scar treatment lack effective integration with Chinese herbal ingredients to enhance wound healing and prevent scar formation, particularly for burns and scalds.
A compound lithospermum silicone gel is formulated by combining lithospermum oil with silicone using a surfactant, incorporating additional herbal ingredients like lithospermum officinale, rhubarb, and beeswax to enhance wound repair and prevent scarring.
The gel effectively repairs burn wounds, reduces scar formation, and promotes faster healing, as demonstrated by improved wound healing rates and tissue regeneration in animal models.
Smart Images
Figure FT_1 
Figure FT_2 
Figure SMS_1
Abstract
Description
Technical Field
[0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a compound lithospermum silicone gel for treating burns and scalds. Background Art
[0002] Silicone preparations have been used in scar treatment research for many years. Many studies have proven that silicone preparations can prevent bacterial infection and water volatilization, making scars soft and smooth, and have certain therapeutic effects. In addition to reducing scars, silicone preparations can also be used to prevent postoperative wound infection and moisturize. Many scientists are also constantly trying to add other drugs to improve the effect of silicone scar removal, but the research on silicone gel combined with Chinese herbal ingredients is still in a preliminary stage.
[0003] As an external preparation widely used in clinical treatment, Lithospermum officinale has been proven to have the effects of clearing heat and cooling blood, detoxifying and relieving pain. While treating trauma patients, it can reduce swelling and relieve pain, clear away heat and dampness, soften scars, lubricate the skin, and heal erosive wounds. In addition, its active ingredient shikonin can induce apoptosis of scar-related cells, which is the most important process in repairing scar tissue. Summary of the invention
[0004] The purpose of the present invention is to provide a composite lithospermum silicone gel for treating burns and scalds, which can not only repair the wound surface of burns and scalds, but also prevent scar formation and is easy to use.
[0005] To achieve the above object, the present invention adopts the following technical solution: A compound lithospermum silicone gel for treating burns and scalds, characterized in that the compound lithospermum silicone gel is formed by fusing compound lithospermum oil and silicone with the aid of a surfactant.
[0006] Furthermore, in terms of mass percentage, the amount of silicone in the compound lithospermum silicone gel is 15% to 25%, the amount of compound lithospermum oil is 60% to 70%, and the amount of surfactant is 10% to 20%.
[0007] Furthermore, the silicone is at least one of silicone elastomer TI-3021, dimethyl silicone oil Q7-9120, dimethyl silicone oil TI-1050, dimethyl silicone oil TI-1050, and silicone resin TI-7012.
[0008] Furthermore, the preparation method of the compound lithospermum officinale oil is as follows: take 8-15g each of lithospermum officinale, raw rhubarb, sanguisorba officinalis, gallnut, etc. (main drugs), 4-8g each of coptis chinensis, polygonum cuspidatum, peony bark, Centella asiatica, etc. (minor drugs), 2-3g each of bletilla striata, frankincense, myrrh, dragon's blood, etc. (adjuvant drugs), 1g of borneol (adjuvant drug), high-speed crushing, passing through a 50-100 mesh sieve, and then soaking in 1000ml tea oil for 15-30 days, and then heating in an oil bath at 90-140℃ for 15-60min, passing through a 200 mesh sieve to remove the drug residue.
[0009] Furthermore, in the preparation of the compound lithospermum officinale oil, scorpion and astragalus as main drugs, and raw rehmannia, cooked rehmannia and wintergreen as auxiliary drugs can be further added to improve the efficacy.
[0010] Furthermore, the surfactant is one or more of C20-24 alkyl dimethyl polysiloxane, octyl trimethicone, lauryl methyl polysiloxane, and cetyl dimethyl polysiloxane.
[0011] Furthermore, beeswax can be added into the compound lithospermum officinale silicone gel to adjust the viscosity.
[0012] Furthermore, the amount of beeswax in the compound lithospermum officinale silicone gel is 5% to 15% by mass.
[0013] The significant advantages of the present invention are: The invention uses various medicinal materials such as lithospermum officinale, raw rhubarb, sanguisorba officinalis, gallnut, coptis root, knotweed, peony bark, centella asiatica and the like to prepare compound lithospermum officinale oil, and then fuses the oil with silicone by means of a surfactant to obtain a gel preparation which can repair burn wounds and prevent scar formation and is easy to use. BRIEF DESCRIPTION OF THE DRAWINGS
[0014] Figure 1 This is a diagram showing the wound healing status of mice in each group treated for different periods of time in efficacy experiment 1.
[0015] Figure 2 HE staining (left) and Masson staining (right) of each group of mice after treatment in efficacy experiment 1. DETAILED DESCRIPTION
[0016] A compound lithospermum silicone gel for treating burns and scalds is prepared by fusing compound lithospermum oil and silicone with the aid of a surfactant; wherein, by mass percentage, the amount of silicone is 15% to 25%, the amount of compound lithospermum oil is 60% to 70%, and the amount of the surfactant is 10% to 20%.
[0017] The silicone is at least one of silicone elastomer TI-3021, dimethyl silicone oil Q7-9120, dimethyl silicone oil TI-1050, dimethyl silicone oil TI-1050, and silicone resin TI-7012.
[0018] The preparation method of the compound lithospermum officinale oil used is as follows: take 8-15g each of lithospermum officinale, raw rhubarb, sanguisorba officinalis, and gallnut (main drugs), 4-5g each of coptis chinensis, knotweed, peony bark, Centella asiatica, etc. (minor drugs), 2-3g each of bletilla striata, frankincense, myrrh, dragon's blood, etc. (adjuvant drugs), and 1g of borneol (assistant drug), grind and mix at high speed, pass through a 50-100 mesh sieve, and then soak in 1000ml of tea oil for 15-30 days, and then heat in an oil bath at 90-140℃ for 15-60min, and pass through a 200 mesh sieve to remove the drug residue.
[0019] The surfactant used is one or more of C20-24 alkyl dimethyl polysiloxane, octyl trimethyl siloxane, lauryl methyl siloxane and cetyl dimethyl polysiloxane.
[0020] Beeswax can also be added to the compound lithospermum erythrorhizon silicone gel to adjust the viscosity. In terms of mass percentage, the amount of beeswax added accounts for 5% to 15% of the compound lithospermum erythrorhizon silicone gel.
[0021] In order to make the contents of the present invention easier to understand, the technical solution of the present invention is further described below in conjunction with specific implementation methods, but the present invention is not limited thereto.
[0022] The silicone used was purchased from Dow Chemical.
[0023] Example 1 A compound lithospermum officinale silicone gel for treating burns and scalds, the preparation steps of which are as follows: 1) Preparation of silicone: Based on the sum of mass percentages being 100%, 20% to 70% of silicone elastomer TI-3021, 15% to 50% of dimethyl silicone oil Q7-9120 (viscosity 12500 cst), and 10% to 20% of dimethyl silicone oil TI-1050 (viscosity 30000 cst) are heated (100°C) and stirred to prepare silicone.
[0024] 2) Preparation of compound lithospermum officinale oil: Take 10g each of lithospermum officinale, raw rhubarb, sanguisorba officinalis, and gallnut, 5g each of coptis chinensis, knotweed, peony bark, and Centella asiatica, 3g each of bletilla striata, frankincense, myrrh, and dragon's blood, and 1g of borneol, grind and mix them at high speed, pass through a 100-mesh sieve, and then soak them in 1000ml of tea oil for one month, and then heat them in an oil bath at 90-140℃ for 15-60min, and then filter the residue with a 200-mesh sieve to obtain the compound lithospermum officinale oil.
[0025] 3) Preparation of compound lithospermum silicone gel: According to mass percentage, 20% of the prepared silicone, 70% of the compound lithospermum oil and 10% of the surfactant octyl polytrimethylsiloxane were mixed to obtain the compound lithospermum silicone gel.
[0026] Example 2 A compound lithospermum officinale silicone gel for treating burns and scalds, the preparation steps of which are as follows: 1) Preparation of silicone: Based on the sum of mass percentages being 100%, 20% to 70% of silicone elastomer TI-3021, 30% to 40% of dimethyl silicone oil Q7-9120 (viscosity 12500 cst), and 10% to 30% of dimethyl silicone oil TI-1050 (viscosity 30000 cst) are heated (100°C) and stirred to prepare silicone.
[0027] 2) Preparation of compound lithospermum officinale oil: Take 10g each of lithospermum officinale, raw rhubarb, sanguisorba officinalis, and gallnut, 5g each of coptis chinensis, knotweed, peony bark, and Centella asiatica, 3g each of bletilla striata, frankincense, myrrh, and dragon's blood, and 1g of borneol, grind and mix them at high speed, pass through a 50-mesh sieve, and then soak them in 1000ml of tea oil for 15 days, and then heat them in an oil bath at 90-140℃ for 15-60min, and then filter the residue with a 200-mesh sieve to obtain the compound lithospermum officinale oil.
[0028] 3) Preparation of compound lithospermum silicone gel: According to mass percentage, 15% of the prepared silicone, 75% of the compound lithospermum oil and 10% of the surfactant lauryl polymethylsiloxane are mixed to obtain the compound lithospermum silicone gel.
[0029] Example 3 A compound lithospermum officinale silicone gel for treating burns and scalds, the preparation steps of which are as follows: 1) Preparation of silicone: first add silicone resin TI-7012 and dimethyl silicone oil Q7-9120 in a mass ratio of (3~4):(6~7) into a container, soak for more than 12 hours, then heat (100℃) and stir with a stainless steel stirrer until completely dissolved, then mix 10%~30% of the dissolved liquid with 30%~50% of silicone elastomer TI-3021 and 30%~40% of dimethyl silicone oil TI-1050 (viscosity 30000cst) in mass percentage to obtain silicone.
[0030] 2) Preparation of compound lithospermum officinale oil: Take 10g each of lithospermum officinale, raw rhubarb, sanguisorba officinalis, and gallnut, 5g each of coptis chinensis, knotweed, peony bark, and Centella asiatica, 3g each of bletilla striata, frankincense, myrrh, and dragon's blood, and 1g of borneol, grind and mix them at high speed, pass through a 50-mesh sieve, and then soak them in 1000ml of tea oil for 15 days, and then heat them in an oil bath at 90-140℃ for 15-60min, and then filter the residue with a 200-mesh sieve to obtain the compound lithospermum officinale oil.
[0031] 3) Preparation of compound lithospermum silicone gel: According to mass percentage, 25% of the prepared silicone, 65% of the compound lithospermum oil and 10% of the surfactant cetyl polydimethylsiloxane were mixed to obtain the compound lithospermum silicone gel.
[0032] Example 4 A compound lithospermum officinale silicone gel for treating burns and scalds, the preparation steps of which are as follows: 1) Preparation of silicone: Based on the sum of mass percentages being 100%, 20% to 70% of silicone elastomer TI-3021, 15% to 50% of dimethyl silicone oil Q7-9120 (viscosity 12500 cst), and 10% to 20% of dimethyl silicone oil TI-1050 (viscosity 30000 cst) are heated (100°C) and stirred to prepare silicone.
[0033] 2) Preparation of compound lithospermum officinale oil: Take 10g each of lithospermum officinale, raw rhubarb, sanguisorba officinalis, and gallnut, 5g each of coptis chinensis, knotweed, peony bark, and Centella asiatica, 3g each of bletilla striata, frankincense, myrrh, and dragon's blood, and 1g of borneol, grind and mix them at high speed, pass through a 100-mesh sieve, and then soak them in 1000ml of tea oil for one month, and then heat them in an oil bath at 90-140℃ for 15-60min, and then filter the residue with a 200-mesh sieve to obtain the compound lithospermum officinale oil.
[0034] 3) Preparation of compound lithospermum silicone gel: According to the mass percentage, 20% of the prepared silicone, 70% of the compound lithospermum oil and 5% of the surfactant octyl trimethicone were mixed, and 5% of beeswax was added to adjust the viscosity to 20000 cst to obtain the compound lithospermum silicone gel.
[0035] Comparative Example A compound lithospermum officinale silicone gel for treating burns and scalds, the preparation steps of which are as follows: 1) Preparation of silicone: Based on the sum of mass percentages being 100%, 20% to 70% of silicone elastomer TI-3021, 15% to 50% of dimethyl silicone oil Q7-9120 (viscosity 12500 cst), and 10% to 20% of dimethyl silicone oil TI-1050 (viscosity 30000 cst) are heated (100°C) and stirred to prepare silicone.
[0036] 2) Preparation of compound lithospermum officinale oil: Take 10g each of lithospermum officinale, raw rhubarb, sanguisorba officinalis, and gallnut, 5g each of coptis root, polygonum cuspidatum, and peony bark, 3g each of bletilla striata, frankincense, myrrh, and dragon's blood, and 1g of borneol, grind and mix them at high speed, pass through a 100-mesh sieve, and then soak them in 1000ml of tea oil for one month, and then heat them in an oil bath at 90-140℃ for 15-60min, and then filter the residue with a 200-mesh sieve to obtain the compound lithospermum officinale oil.
[0037] 3) Preparation of compound lithospermum silicone gel: According to the mass percentage, 20% of the prepared silicone, 70% of the compound lithospermum oil and 5% of the surfactant octyl trimethicone were mixed, and 5% of beeswax was added to adjust the viscosity to 20000 cst to obtain the compound lithospermum silicone gel.
[0038] Efficacy Experiment 1. 50 ICR mice were selected and randomly divided into 5 groups, namely, model group, silicone group, compound lithospermum oil group, compound lithospermum silicone gel group and control group. After the mice in each group were scalded to establish the scald model, the model group was not given any medication, the silicone group, compound lithospermum oil group and compound lithospermum silicone gel group were smeared with equal amounts of silicone, compound lithospermum oil and compound lithospermum silicone gel prepared in Example 4, respectively, and the control group was smeared with equal amounts of compound lithospermum silicone gel prepared in the comparative example for treatment, once a day, for 21 consecutive days. After the start of treatment, the wound area after scalding was measured on days 0, 3, 7, 14 and 21, the wound healing rate was calculated and photographed for archiving; the results are shown in Figure 1 , 2 And Table 1.
[0039] Depend on Figure 1 It can be seen that the compound lithospermum silicone gel group formed scabs first and had the shortest wound healing time; compared with the model group and the control group, the wound healing rate of the compound lithospermum silicone gel group was significantly improved (P < 0.05). Figure 2 It can be seen from the results of HE staining and Masson staining of the healed skin tissue that the epidermal hyperplasia in the compound lithospermum silicone gel group was milder and the blood vessels grew more, and the collagen fibers proliferated appropriately, which was beneficial to wound repair.
[0040] Table 1 Wound healing rate of mice in each group at different time points (%)
[0041] As shown in Table 1, on the 7th day after treatment, the wound healing rates of the silicone group, compound lithospermum oil group, and compound lithospermum silicone gel group were 39.89%, 30.67%, and 47.47%, respectively, which were significantly higher than 25.95% of the model group (P < 0.05); on the 14th day after treatment, compared with the model group, the wound healing rates of the other groups were significantly improved (P < 0.05), among which the healing rate of the compound lithospermum silicone gel group was significantly better than that of the other groups; on the 21st day after treatment, compared with the model group, the wound healing rates of the silicone group, compound lithospermum oil group, and compound lithospermum silicone gel group were significantly improved (P < 0.05); compared with the control group, the wound healing rate of the compound lithospermum silicone gel group was significantly increased (P < 0.05).
[0042] 2. 40 ICR mice were selected and randomly divided into 4 groups. After the mice in each group were scalded to establish the scald model, they were treated with the same amount of the compound lithospermum silicone gel prepared in Examples 1 to 4, once a day for 21 consecutive days. After the start of treatment, the wound area after scalding was measured on the 0th, 3rd, 7th, 14th and 21st days, and the wound healing rate was calculated and photographed for archiving. The results are shown in Table 2.
[0043] Table 2 Wound healing rate of mice in each group at different time points (%)
[0044] As can be seen from Table 2, compared with the compound lithospermum silicone gel prepared in Examples 2 and 3, the wound surface healed faster using the compound lithospermum silicone gel prepared in Example 1, indicating that a better effect can be achieved by combining silicone and compound lithospermum oil in a ratio of 2:7; and compared with Example 1, the healing effect of the compound lithospermum silicone gel prepared in Example 4 was better, indicating that the addition of beeswax in the formula helps to further promote wound healing and prevent the appearance of scars.
[0045] The above description is only a preferred embodiment of the present invention. All equivalent changes and modifications made according to the scope of the patent application of the present invention should fall within the scope of the present invention.
Claims
1. A compound lithospermum officinale silicone gel for treating burns and scalds, characterized in that: The compound lithospermum silicone gel is formed by fusing compound lithospermum oil and silicone with the aid of a surfactant; Among them, calculated by mass percentage, the amount of silicone is 15%~25%, the amount of compound lithospermum oil is 60%~70%, and the amount of surfactant is 10%~20%.
2. The compound lithospermum officinale silicone gel according to claim 1, characterized in that: The compound lithospermum officinale oil is prepared from 8-15g of lithospermum officinale, raw rhubarb, sanguisorba officinalis, and gallnut, 4-5g of coptis root, polygonum cuspidatum, peony bark, and centella asiatica, 2-3g of bletilla striata, frankincense, myrrh, and dragon's blood, and 1g of borneol. The mixture is crushed and mixed at high speed, passed through a 50-100 mesh sieve, and then soaked in 1000ml of tea oil for 15-30 days, and then heated in an oil bath at 90-140°C for 15-60min, and passed through a 200 mesh sieve to remove the drug residues.
3. The compound lithospermum officinale silicone gel according to claim 1, characterized in that: The surfactant is one or more of C20-24 alkyl dimethyl polysiloxane, octyl trimethyl siloxane, lauryl methyl siloxane and cetyl dimethyl polysiloxane.
4. The compound lithospermum officinale silicone gel according to claim 1, characterized in that: Beeswax is also added to the composite lithospermum officinale silicone gel, and the amount thereof is 5% to 15% by weight.