Rosuvastatin intermediate grinding equipment and process

Abstract

The invention discloses a rosuvastatin intermediate grinding device and process, and relates to the technical field of rosuvastatin intermediate grinding.The rosuvastatin intermediate grinding device is characterized in that a controller is fixedly connected to the top end of a bottom plate, a servo motor is fixedly connected to the end, away from the controller, of the top of the bottom plate, and the controller is slidably connected with a grinding base; the grinding base is fixedly connected with a grinding assembly, the grinding bin is arranged at the top of the bottom plate, the inner wall of the grinding bin is slidably connected with a bearing plate, the upper end and the lower end of the rotating shaft are fixedly connected with the bearing plate and the servo motor respectively, and the base table is arranged between the grinding assembly and the bearing plate and is parallel to the bottom plate. The bottom end of the lifting rod is fixedly connected with a cleaning bottom plate, and the cleaning bottom plate is rotationally connected with the bearing plate. The cleaning bottom plate is used for cleaning the rosuvastatin intermediates left on the surface of the bearing plate, so that the cleanliness of the surface of the bearing plate is guaranteed, and the cleaning assembly is used for cleaning the surface of the grinding plate.

Description

Technical Field

[0001] The invention relates to the technical field of rosuvastatin intermediate grinding, and in particular to rosuvastatin intermediate grinding equipment and process. Background Art

[0002] Rosuvastatin intermediates are white and off-white powders used in the production of rosuvastatin calcium. Rosuvastatin intermediates contain different chemical components. The product is used to treat hyperlipidemia and hypercholesterolemia in patients.

[0003] In the prior art, during the production process of rosuvastatin intermediates, grinding equipment is often required for grinding. The grinding equipment is mainly composed of a grinding rod, a grinding chamber and a motor. The rosuvastatin intermediate is placed in the grinding chamber, and the motor drives the grinding rod to rotate. The rotating grinding rod grinds the rosuvastatin intermediate, and the staff takes the ground rosuvastatin intermediate out of the grinding chamber.

[0004] However, after the rosuvastatin intermediate is ground in the grinding chamber, the staff needs to take it out from the grinding chamber, which is time-consuming and labor-intensive. In addition, there is a phenomenon of residual rosuvastatin intermediate in the grinding chamber. When the grinding device grinds rosuvastatin intermediates of other chemical components, the residual rosuvastatin intermediate will cause different rosuvastatin intermediates in the grinding chamber to mix, thereby affecting the use effect of the grinding device. Summary of the invention

[0005] The object of the present invention is to provide a rosuvastatin intermediate grinding device and process to solve the technical problem that there is residual rosuvastatin intermediate in the grinding chamber of the grinding device in the prior art, which leads to the mixing of rosuvastatin intermediates of different chemical components.

[0006] The technical problem to be solved by the present invention can be achieved by the following technical solutions:

[0007] A rosuvastatin intermediate grinding device, comprising:

[0008] A bottom plate, wherein the top of the bottom plate is fixedly connected to a controller, an end of the top of the bottom plate away from the controller is fixedly connected to a servo motor, the controller is slidably connected to a grinding seat, and the grinding seat is fixedly connected to a grinding assembly;

[0009] A grinding bin is arranged on the top of the bottom plate, the inner wall of the grinding bin is slidably connected to a bearing plate, the outer wall of the grinding bin is fixedly connected to a connecting plate, the top of the connecting plate is butted against and connected to a recovery bucket, the side end of the connecting plate is fixedly connected to a connecting slide, the connecting slide is slidably connected to a controller, a rotating shaft is arranged between the bearing plate and the servo motor, the top of the bearing plate is conical, and the upper and lower ends of the rotating shaft are respectively fixedly connected to the bearing plate and the servo motor;

[0010] The base is arranged between the grinding assembly and the supporting plate and is parallel to the bottom plate. A groove is provided at the bottom of the base. A lifting rod is fixedly connected to the bottom end of the base. A cleaning bottom plate is fixedly connected to the bottom end of the lifting rod. The cleaning bottom plate is rotatably connected to the supporting plate.

[0011] As a further solution of the present invention: two sets of guide rails are provided on the top of the bottom plate, both ends of the top plate are sleeved on the guide rails and slidably connected to the guide rails, both ends of the guide rails are fixedly connected with support plates, and the bottom end of the support plate is fixedly connected to the bottom plate.

[0012] As a further solution of the present invention: the grinding assembly includes: a grinding plate, a grinding shaft and a grinder, the side end of the grinder is fixedly connected to the grinding seat, the upper and lower ends of the grinding shaft are respectively fixedly connected to the grinder and the grinding plate, the bottom end of the grinding plate is rotatably connected to a cleaning assembly, the grinding plate cooperates with the supporting plate, the bottom end of the cleaning assembly is fixedly connected to a top plate in a direction perpendicular to the axis of the recovery barrel, and the top plate is fixedly connected to the top of the base.

[0013] As a further solution of the present invention: the cleaning assembly includes: a grinding and cleaning plate, a feed pipe, a collecting seat, a lifter, an absorber and a supporting rod. The top of the grinding and cleaning plate is in contact with the grinding plate and is rotatably connected. The grinding and cleaning plate is axially provided with a plurality of feed holes. The upper and lower ends of the supporting rod are respectively fixedly connected to the grinding and cleaning plate and the lifter. The bottom ends of the lifter and the supporting rod are fixedly connected to the top plate. The collecting seat is fixedly connected to the top of the absorber. The upper and lower ends of the feed pipe are respectively fixedly connected to the grinding and cleaning plate and the collecting seat.

[0014] As a further solution of the present invention: a collecting groove is provided inside the collecting seat, and the discharge pipe is respectively communicated with the discharge hole and the collecting groove.

[0015] As a further solution of the present invention: the width of the top plate is greater than the width of the base, a groove is provided on the top of the recycling barrel, the base is slidably connected to the inner wall of the groove, and the top plate is slidably connected to the top of the recycling barrel.

[0016] As a further solution of the present invention: a feeder is fixedly connected to the side end of the base, a feeding hole is opened inside the base, and the feeding hole cooperates with the grinding bin.

[0017] As a further solution of the present invention: handles are fixedly connected to both ends of the recycling barrel, and the connecting plate passes through the bottom of the recycling barrel and is provided with a threaded hole, and a bolt is threadedly connected in the threaded hole.

[0018] A process for grinding a rosuvastatin intermediate comprises the following steps:

[0019] In the first step, the rosuvastatin intermediate is automatically unloaded. When the grinding of the rosuvastatin intermediate is completed, the grinding assembly is detached from the grinding bin by sliding upward along the grinding seat, and the connecting plate moves downward along the controller through the connecting slide seat. The connecting plate moves downward with the recovery barrel and the grinding bin. When the top of the grinding bin is lower than the carrying plate, the rosuvastatin intermediate carried by the carrying plate automatically begins to fall into the recovery barrel, and the recovery barrel collects the unloaded rosuvastatin intermediate.

[0020] In the second step, the surface of the grinding plate and the carrier plate are cleaned, the base moves to the top of the carrier plate, the base drives the lifting rod to move downward, the lifting rod drives the cleaning bottom plate to move downward, the cleaning bottom plate and the carrier plate fit together, when the servo motor drives the carrier plate to rotate through the rotating shaft, the cleaning bottom plate cleans the rosuvastatin intermediates left on the surface of the carrier plate, the cleaning assembly fixed on the top of the top plate is aligned with the grinding plate, the grinding cleaning plate is aligned with the grinding plate, the grinding plate moves downward, the grinding plate and the grinding cleaning plate are embedded in the grinding cleaning plate, when the grinding plate and the grinding cleaning plate fit together, when the grinding plate rotates, the rosuvastatin intermediates on the surface of the grinding plate are cleaned by the grinding cleaning plate and enter the feeding pipe through the feeding hole, and then enter the collecting tank, the absorber runs, and the absorber absorbs the rosuvastatin intermediates in the feeding pipe and the collecting tank.

[0021] The third step is to automatically load the rosuvastatin intermediate. When the rosuvastatin intermediate is completely taken out from the surface of the carrier plate, the base continues to move, and the connecting plate moves downward with the grinding bin and the recovery barrel. When the loading hole is aligned with the grinding bin, the loader runs and passes the rosuvastatin intermediate to be ground into the grinding bin.

[0022] Beneficial effects of the present invention:

[0023] 1. Rosuvastatin intermediates are stored in the grinding bin, and the supporting plate provides support for the rosuvastatin intermediates. The grinding assembly moves downward along the controller through the grinding seat, and the servo motor drives the supporting plate to rotate through the rotating shaft. The grinding assembly grinds the rosuvastatin intermediates. When the grinding of the rosuvastatin intermediates is finished, the grinding assembly slides upward from the grinding bin through the grinding seat, and the connecting plate moves downward along the controller through the connecting slide. The connecting plate moves downward with the recovery barrel and the grinding bin. When the top of the grinding bin is lower than the supporting plate, the rosuvastatin intermediates carried by the supporting plate automatically begin to fall into the recovery barrel, and the recovery barrel collects the unloaded rosuvastatin intermediates, thereby avoiding the time-consuming and laborious collection of rosuvastatin intermediates by the staff.

[0024] 2. The base moves to the top of the carrier plate, and the base drives the lifting rod to move downward, and the lifting rod drives the cleaning bottom plate to move downward, and the cleaning bottom plate and the carrier plate are fitted together. When the servo motor drives the carrier plate to rotate through the rotating shaft, the cleaning bottom plate cleans the rosuvastatin intermediates remaining on the surface of the carrier plate, thereby ensuring the cleanliness of the surface of the carrier plate and avoiding the phenomenon that the rosuvastatin intermediates remain on the carrier plate and rosuvastatin intermediates of different chemical components are mixed. It should be noted that when the cleaning bottom plate is cleaned, the lifting rod moves upward with the cleaning bottom plate, and the cleaning bottom plate is stored in the opened groove. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] The present invention will be further described below in conjunction with the accompanying drawings.

[0026] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0027] Figure 2 It is a right view of the overall structure of the present invention;

[0028] Figure 3 It is the AA cross-sectional view of the overall structure of the present invention;

[0029] Figure 4 For the present invention Figure 3 A schematic diagram of the structure at A;

[0030] Figure 5 For the present invention Figure 4 A schematic diagram of the structure at B;

[0031] Figure 6 It is a schematic diagram of the base structure of the present invention;

[0032] Figure 7 It is a schematic diagram of the structure of the cleaning component of the present invention;

[0033] Figure 8 It is a schematic diagram of the connecting plate structure of the present invention;

[0034] Fig. 9 This is a schematic diagram of the recycling barrel structure of the present invention;

[0035] Fig.10 It is a schematic diagram of the structure of the bearing plate of the present invention.

[0036] In the figure: 1. bottom plate; 2. support plate; 3. guide rail; 4. loader; 5. base; 6. top plate; 7. servo motor; 8. recovery barrel; 9. grinding plate; 10. grinding shaft; 11. grinder; 12. grinding seat; 13. controller; 14. loading hole; 15. grinding cleaning plate; 16. lifting rod; 17. cleaning bottom plate; 18. handle; 19. threaded hole; 20. connecting plate; 21. bolt; 22. grinding chamber; 23. rotating shaft; 24. unloading hole; 25. unloading pipe; 26. collecting seat; 27. collecting trough; 28. lifter; 29. ​​absorber; 30. supporting rod; 31. connecting slide; 32. bearing plate. DETAILED DESCRIPTION

[0037] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0038] like Figure 1-Figure 10 As shown, a rosuvastatin intermediate grinding device and process comprises: a bottom plate 1, a grinding chamber 22 and a base 5,

[0039] The top of the bottom plate 1 is fixedly connected to a controller 13, and one end of the top of the bottom plate 1 away from the controller 13 is fixedly connected to a servo motor 7. The controller 13 is slidably connected to a grinding seat 12, and the grinding seat 12 is fixedly connected to a grinding assembly. A grinding bin 22 is arranged on the top of the bottom plate 1, and a bearing plate 32 is slidably connected to the inner wall of the grinding bin 22, and a connecting plate 20 is fixedly connected to the outer wall of the grinding bin 22. A recycling barrel 8 is abutted and connected to the top of the connecting plate 20, and a connecting slide 31 is fixedly connected to the side end of the connecting plate 20. The connecting slide 31 is slidably connected to the controller 13. A rotating shaft 23 is provided between the bearing plate 32 and the servo motor 7, and the top of the bearing plate 32 is conical. The upper and lower ends of the rotating shaft 23 are respectively fixedly connected to the bearing plate 32 and the servo motor 7. Rosuvastatin intermediates are stored in the grinding bin 22, and the bearing plate 32 is Rosuvastatin intermediate. The rosuvastatin intermediate provides support, the grinding assembly moves downward along the controller 13 through the grinding seat 12, the servo motor 7 drives the carrying plate 32 to rotate through the rotating shaft 23, and the grinding assembly grinds the rosuvastatin intermediate. When the grinding of the rosuvastatin intermediate is completed, the grinding assembly slides upward through the grinding seat 12 and disengages from the grinding bin 22, the connecting plate 20 moves downward along the controller 13 through the connecting slide 31, and the connecting plate 20 moves downward with the recovery barrel 8 and the grinding bin 22. When the top of the grinding bin 22 is lower than the carrying plate 32, the rosuvastatin intermediate carried by the carrying plate 32 automatically starts to fall into the recovery barrel 8, and the recovery barrel 8 collects the unloaded rosuvastatin intermediate, thereby avoiding the time-consuming and laborious collection of the rosuvastatin intermediate by the staff;

[0040] The base 5 is arranged between the grinding assembly and the carrying plate 32 and is parallel to the bottom plate 1. A groove is provided at the bottom of the base 5. A lifting rod 16 is fixedly connected to the bottom end of the base 5. A cleaning bottom plate 17 is fixedly connected to the bottom end of the lifting rod 16. The cleaning bottom plate 17 is rotatably connected to the carrying plate 32. The base 5 moves to the top of the carrying plate 32. The base 5 drives the lifting rod 16 to move downward. The lifting rod 16 drives the cleaning bottom plate 17 to move downward. The cleaning bottom plate 17 and the carrying plate 32 are fitted together. When the servo motor 7 drives the carrying plate 32 to rotate through the rotating shaft 23, the cleaning bottom plate 17 cleans the rosuvastatin intermediate remaining on the surface of the carrying plate 32, thereby ensuring the cleanliness of the surface of the carrying plate 32 and avoiding the phenomenon that the rosuvastatin intermediate remains on the carrying plate 32 and rosuvastatin intermediates of different chemical components are mixed. It should be noted that when the cleaning bottom plate 17 is cleaned, the lifting rod 16 moves upward with the cleaning bottom plate 17, and the cleaning bottom plate 17 is stored in the groove 5.

[0041] In some specific embodiments, two sets of guide rails 3 are provided on the top of the bottom plate 1, and both ends of the top plate 6 are sleeved on the guide rails 3 and slidably connected to the guide rails 3. Both ends of the guide rails 3 are respectively fixedly connected to support plates 2, and the bottom end of the support plate 2 is fixedly connected to the bottom plate 1. When the base 5 needs to be moved, the two ends of the top plate 6 slide along the guide rails 3, thereby driving the base 5 to translate.

[0042] In some specific embodiments, the grinding assembly includes: a grinding plate 9, a grinding shaft 10 and a grinder 11, the side end of the grinder 11 is fixedly connected to the grinding seat 12, the upper and lower ends of the grinding shaft 10 are respectively fixedly connected to the grinder 11 and the grinding plate 9, the bottom end of the grinding plate 9 is rotatably connected to a cleaning assembly, the grinding plate 9 cooperates with the supporting plate 32, the bottom end of the cleaning assembly is fixedly connected to the top plate 6 in a direction perpendicular to the axis of the recovery barrel 8, and the top plate 6 is fixedly connected to the top of the base 5. When the grinding assembly is running, the grinding plate 9 contacts the rosuvastatin intermediate, the grinder 11 drives the grinding shaft 10 to rotate in the opposite direction of the rotating shaft 23, and the grinding shaft 10 drives the grinding plate 9 to rotate in the opposite direction of the supporting plate 32, so that the rosuvastatin intermediate is ground. When the grinding assembly ends, rosuvastatin intermediates remain on the surface of the grinding plate 9, and the cleaning assembly cleans the rosuvastatin intermediates on the surface of the grinding plate 9.

[0043] In some specific embodiments, the cleaning assembly includes: a grinding and cleaning plate 15, a feed tube 25, a collecting seat 26, a lifter 28, an absorber 29 and a supporting rod 30. The top of the grinding and cleaning plate 15 is fitted with and rotatably connected to the grinding plate 9. The grinding and cleaning plate 15 is axially provided with a plurality of feed holes 24. The upper and lower ends of the supporting rod 30 are respectively fixedly connected to the grinding and cleaning plate 15 and the lifter 28. The lower ends of the lifter 28 and the supporting rod 30 are fixedly connected to the top plate 6. The collecting seat 26 is fixedly connected to the top of the absorber 29. The upper and lower ends of the feed tube 25 are respectively fixedly connected to the grinding and cleaning plate 15 and the collecting seat 26. A collecting groove 27 is provided inside the collecting seat 26. The feed tube 25 is respectively connected to the feed hole 24 and the collecting groove 27. When the base 5 moves to the supporting plate 32, the cleaning assembly fixed on the top of the top plate 6 is aligned with the grinding plate 9, the grinding and cleaning plate 15 is aligned with the grinding plate 9, the lifter 28 controls the supporting rod 30 to move the grinding and cleaning plate 15 upward, the discharge pipe 25 reserves a sufficient length, the grinding plate 9 is embedded in the grinding and cleaning plate 15, when the grinding plate 9 and the grinding and cleaning plate 15 are in contact, when the grinding plate 9 rotates, the rosuvastatin intermediate on the surface of the grinding plate 9 is cleaned by the grinding and cleaning plate 15 and enters the discharge pipe 25 through the discharge hole 24, and then enters the collecting tank 27, the absorber 29 runs, and the absorber 29 absorbs the rosuvastatin intermediate in the discharge pipe 25 and the collecting tank 27 to avoid splashing when the grinding and cleaning plate 15 cleans the rosuvastatin intermediate on the surface of the grinding plate 9.

[0044] In some specific embodiments, the width of the top plate 6 is greater than the width of the base 5, a groove is provided on the top of the recovery barrel 8, the base 5 is slidably connected to the inner wall of the groove, and the top plate 6 is slidably connected to the top of the recovery barrel 8. When the base 5 moves to the top of the supporting plate 32, the top plate 6 seals the top of the recovery barrel 8, and the base 5 and the groove are sealed together. When the cleaning bottom plate 17 cleans the rosuvastatin intermediate on the surface of the supporting plate 32, the rosuvastatin intermediate is prevented from splashing and escaping from the recovery barrel 8.

[0045] In some specific embodiments, a loader 4 is fixedly connected to the side end of the base 5, and a loading hole 14 is opened inside the base 5, and the loading hole 14 cooperates with the grinding bin 22. When the rosuvastatin intermediate is completely taken out from the surface of the supporting plate 32, the base 5 continues to move, and the connecting plate 20 moves downward with the grinding bin 22 and the recovery barrel 8. When the loading hole 14 is aligned with the grinding bin 22, the loader 4 runs, and the loader 4 passes the rosuvastatin intermediate to be ground into the grinding bin 22, thereby achieving the effect of automatic loading of the rosuvastatin intermediate.

[0046] In some specific embodiments, handles 18 are fixedly connected at both ends of the recovery barrel 8, and a connecting plate 20 is provided with a threaded hole 19 through the bottom of the recovery barrel 8. A bolt 21 is threadedly connected to the threaded hole 19. When the rosuvastatin intermediate stored in the recovery barrel 8 is removed, the bolt 21 is rotated to release the threaded connection between the bolt 21 and the threaded hole 19, and the staff controls the handle 18 to move the recovery barrel 8 upward.

[0047] In order to facilitate the understanding of the embodiments of this solution by those skilled in the art, the working principle of this solution is briefly described in combination with specific application scenarios:

[0048] In the first step, the rosuvastatin intermediate is automatically unloaded. When the grinding of the rosuvastatin intermediate is completed, the grinding assembly is disengaged from the grinding bin 22 by sliding upwards through the grinding seat 12, and the connecting plate 20 moves downward along the controller 13 through the connecting slide 31. The connecting plate 20 moves downward with the recovery barrel 8 and the grinding bin 22. When the top of the grinding bin 22 is lower than the supporting plate 32, the rosuvastatin intermediate carried by the supporting plate 32 automatically begins to fall into the recovery barrel 8, and the recovery barrel 8 collects the unloaded rosuvastatin intermediate.

[0049] In the second step, the surface of the grinding plate 9 and the carrier plate 32 are cleaned. The base 5 moves to the top of the carrier plate 32, and the base 5 drives the lifting rod 16 to move downward. The lifting rod 16 drives the cleaning bottom plate 17 to move downward. The cleaning bottom plate 17 and the carrier plate 32 are fitted together. When the servo motor 7 drives the carrier plate 32 to rotate through the rotating shaft 23, the cleaning bottom plate 17 cleans the rosuvastatin intermediate left on the surface of the carrier plate 32. The cleaning component fixed on the top of the top plate 6 is aligned with the grinding plate 9, and the grinding cleaning plate 15 is aligned with the grinding plate 9. The lifter 28 controls the supporting rod 30 to move the grinding and cleaning plate 15 upward, and the discharge pipe 25 reserves a sufficient length. The grinding plate 9 is embedded in the grinding and cleaning plate 15. When the grinding plate 9 and the grinding and cleaning plate 15 are in contact, when the grinding plate 9 rotates, the rosuvastatin intermediate on the surface of the grinding plate 9 is cleaned by the grinding and cleaning plate 15 and enters the discharge pipe 25 through the discharge hole 24, and then enters the collecting tank 27. The absorber 29 runs, and the absorber 29 absorbs the rosuvastatin intermediate in the discharge pipe 25 and the collecting tank 27.

[0050] The third step is to automatically load the rosuvastatin intermediate. When the rosuvastatin intermediate is completely taken out from the surface of the carrier plate 32, the base 5 continues to move, and the connecting plate 20 moves downward with the grinding bin 22 and the recovery barrel 8. When the loading hole 14 is aligned with the grinding bin 22, the loader 4 runs, and the loader 4 passes the rosuvastatin intermediate to be ground into the grinding bin 22.

[0051] The connecting plate 20 controls the recovery barrel 8 and the grinding chamber 22 to automatically move downward, and the rosuvastatin intermediate carried by the carrying plate 32 automatically falls into the recovery barrel 8, thereby avoiding the time-consuming and laborious collection of the rosuvastatin intermediate by the staff;

[0052] The cleaning bottom plate 17 cleans the rosuvastatin intermediate remaining on the surface of the carrier plate 32, thereby ensuring the cleanliness of the surface of the carrier plate 32 and avoiding the phenomenon that the rosuvastatin intermediate remains on the carrier plate 32 and rosuvastatin intermediates of different chemical components are mixed. The cleaning component cleans the surface of the grinding plate 9, wherein the absorber 29 absorbs the rosuvastatin intermediate in the feed pipe 25 and the collecting tank 27, avoiding the phenomenon of splashing when the grinding cleaning plate 15 cleans the rosuvastatin intermediate on the surface of the grinding plate 9.

[0053] Several embodiments of the present invention are described in detail above, but the embodiments of the present invention are not limited thereto and cannot be considered to limit the scope of implementation of the present invention. All equivalent changes and improvements made within the scope of the present invention should still fall within the scope of the patent coverage of the present invention.

Claims

1. A rosuvastatin intermediate grinding device, characterized in that: include: A base plate (1), the top of the base plate (1) being fixedly connected to a controller (13), an end of the top of the base plate (1) away from the controller (13) being fixedly connected to a servo motor (7), the controller (13) being slidably connected to a grinding seat (12), and the grinding seat (12) being fixedly connected to a grinding assembly; A grinding bin (22), wherein the grinding bin (22) is arranged on the top of the bottom plate (1), the inner wall of the grinding bin (22) is slidably connected to a bearing plate (32), the outer wall of the grinding bin (22) is fixedly connected to a connecting plate (20), the top of the connecting plate (20) is butted against and connected to a recovery bucket (8), the side end of the connecting plate (20) is fixedly connected to a connecting slide (31), the connecting slide (31) is slidably connected to a controller (13), a rotating shaft (23) is provided between the bearing plate (32) and the servo motor (7), the top of the bearing plate (32) is conical, and the upper and lower ends of the rotating shaft (23) are respectively fixedly connected to the bearing plate (32) and the servo motor (7); A base (5), the base (5) is arranged between the grinding assembly and the supporting plate (32) and is parallel to the bottom plate (1), a groove is provided at the bottom of the base (5), a lifting rod (16) is fixedly connected to the bottom end of the base (5), a cleaning bottom plate (17) is fixedly connected to the bottom end of the lifting rod (16), and the cleaning bottom plate (17) is rotatably connected to the supporting plate (32).

2. A rosuvastatin intermediate grinding device according to claim 1, characterized in that: Two sets of guide rails (3) are provided on the top of the bottom plate (1), the two ends of the top plate (6) are sleeved on the guide rails (3) and are slidably connected to the guide rails (3), the two ends of the guide rails (3) are respectively fixedly connected to support plates (2), and the bottom end of the support plate (2) is fixedly connected to the bottom plate (1).

3. A rosuvastatin intermediate grinding device according to claim 1, characterized in that: The grinding assembly comprises: a grinding plate (9), a grinding shaft (10) and a grinder (11); the side end of the grinder (11) is fixedly connected to the grinding seat (12); the upper and lower ends of the grinding shaft (10) are respectively fixedly connected to the grinder (11) and the grinding plate (9); the bottom end of the grinding plate (9) is rotatably connected to a cleaning assembly; the grinding plate (9) cooperates with a bearing plate (32); the bottom end of the cleaning assembly is fixedly connected to a top plate (6) in a direction perpendicular to the axis of the recovery barrel (8); and the top plate (6) is fixedly connected to the top of the base (5).

4. A rosuvastatin intermediate grinding device according to claim 3, characterized in that: The cleaning assembly comprises: a grinding and cleaning plate (15), a feeding tube (25), a collecting seat (26), a lifter (28), an absorber (29) and a supporting rod (30); the top end of the grinding and cleaning plate (15) is fitted with and rotatably connected to the grinding plate (9); a plurality of feeding holes (24) are axially opened on the grinding and cleaning plate (15); the upper and lower ends of the supporting rod (30) are respectively fixedly connected to the grinding and cleaning plate (15) and the lifter (28); the bottom ends of the lifter (28) and the supporting rod (30) are fixedly connected to the top plate (6); the collecting seat (26) is fixedly connected to the top end of the absorber (29); the upper and lower ends of the feeding tube (25) are respectively fixedly connected to the grinding and cleaning plate (15) and the collecting seat (26).

5. A rosuvastatin intermediate grinding device according to claim 4, characterized in that: A collecting groove (27) is provided inside the collecting seat (26), and the discharge pipe (25) is respectively communicated with the discharge hole (24) and the collecting groove (27).

6. A rosuvastatin intermediate grinding device according to claim 3, characterized in that: The width of the top plate (6) is greater than the width of the base (5); a groove is provided on the top of the recycling bucket (8); the base (5) is slidably connected to the inner wall of the groove; and the top plate (6) is slidably connected to the top of the recycling bucket (8).

7. The rosuvastatin intermediate grinding equipment according to claim 1, characterized in that: A loader (4) is fixedly connected to the side end of the base (5), and a loading hole (14) is provided inside the base (5), and the loading hole (14) cooperates with the grinding bin (22).

8. The rosuvastatin intermediate grinding equipment according to claim 1, characterized in that: The two ends of the recycling bucket (8) are respectively fixedly connected with handles (18); the connecting plate (20) passes through the bottom of the recycling bucket (8) and is provided with a threaded hole (19); a bolt (21) is threadedly connected to the inner surface of the threaded hole (19).

9. A process for grinding a rosuvastatin intermediate according to any one of claims 1 to 8, characterized in that: The steps include: S1: Rosuvastatin intermediates are automatically unloaded. When the grinding of rosuvastatin intermediates is completed, the grinding assembly is disengaged from the grinding chamber (22) by sliding upward along the grinding seat (12), and the connecting plate (20) moves downward along the controller (13) through the connecting slide seat (31). The connecting plate (20) moves downward with the recovery barrel (8) and the grinding chamber (22). When the top of the grinding chamber (22) is lower than the carrying plate (32), the rosuvastatin intermediates carried by the carrying plate (32) automatically begin to fall into the recovery barrel (8), and the recovery barrel (8) collects the unloaded rosuvastatin intermediates. S2: The surfaces of the grinding plate (9) and the carrier plate (32) are cleaned. The base (5) moves to the top of the carrier plate (32). The base (5) drives the lifting rod (16) to move downward. The lifting rod (16) drives the cleaning bottom plate (17) to move downward. The cleaning bottom plate (17) and the carrier plate (32) are fitted together. When the servo motor (7) drives the carrier plate (32) to rotate via the rotating shaft (23), the cleaning bottom plate (17) cleans the rosuvastatin intermediate remaining on the surface of the carrier plate (32). The cleaning assembly fixed at the top of the top plate (6) is aligned with the grinding plate (9). The grinding and cleaning process is performed. The plate (15) is aligned with the grinding plate (9), the grinding plate (9) moves downward, the grinding plate (9) and the grinding cleaning plate (15) are embedded in the grinding cleaning plate (15), when the grinding plate (9) and the grinding cleaning plate (15) are in contact, when the grinding plate (9) rotates, the rosuvastatin intermediate on the surface of the grinding plate (9) is cleaned by the grinding cleaning plate (15) and enters the discharge pipe (25) through the discharge hole (24), and then enters the collection tank (27), the absorber (29) operates, and the absorber (29) absorbs the rosuvastatin intermediate in the discharge pipe (25) and the collection tank (27); S3: Rosuvastatin intermediate is automatically loaded. When the rosuvastatin intermediate is completely taken out from the surface of the carrier plate (32), the base (5) continues to move, and the connecting plate (20) moves downward with the grinding chamber (22) and the recovery barrel (8). When the loading hole (14) is aligned with the grinding chamber (22), the loader (4) operates, and the loader (4) passes the rosuvastatin intermediate to be ground into the grinding chamber (22).

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