Pretreatment device of analyzer and analyzer

Abstract

The pretreatment device comprises a sample pipe frame mechanism, a lifting mechanism and an ultrasonic mechanism, the sample pipe frame mechanism comprises a main body, a plurality of clamping mechanisms and a clamping driving mechanism, the clamping driving mechanism is fixed to the main body, the clamping mechanisms are movably connected with the main body, the lifting mechanism is fixed to the main body, and the ultrasonic mechanism is fixed to the main body. The plurality of clamping mechanisms are connected with the clamping driving mechanism; the lifting mechanism is fixedly connected with the main body; the ultrasonic mechanism comprises an ultrasonic water tank and an ultrasonic generation assembly, the ultrasonic water tank is arranged below the multiple clamping mechanisms, and the ultrasonic generation assembly is arranged in the ultrasonic water tank. The ultrasonic waves generated by the ultrasonic wave generating assembly take water as a propagation medium, so that direct contact with the sample tube can be avoided, and further the condition that contents in sample cells are broken due to excessive vibration of the ultrasonic waves can be prevented. Meanwhile, the device can clamp a plurality of sample tubes through a plurality of clamping mechanisms, so that the samples in the plurality of sample tubes can be subjected to ultrasonic splitting decomposition at the same time, and the ultrasonic splitting decomposition efficiency is improved.

Description

Technical Field

[0001] The present application relates to the technical field of medical equipment, and in particular to a pre-processing device of an analyzer and an analyzer. Background Art

[0002] Cell lysis is a method of destroying cells and releasing intracellular substances. Cell lysis can be applied in many fields, such as isolating intracellular proteins, extracting genomic DNA or RNA, and studying cell metabolic pathways.

[0003] At present, ultrasonic lysis is the main method for cell lysis. In related technologies, ultrasonic lysis equipment mostly puts the ultrasonic probe in direct contact with the sample tube, which can easily damage cells during the ultrasonic lysis process and even cause nucleic acid fragments to be excessively broken, affecting downstream detection. Summary of the invention

[0004] The present application aims to provide a pre-processing device of an analyzer and an analyzer, which can prevent an ultrasonic probe from directly contacting a sample tube.

[0005] According to a first aspect of the present application, the present application provides a pre-processing device of an analyzer, comprising:

[0006] The sample tube rack mechanism comprises a main body, a plurality of clamping mechanisms and a clamping drive mechanism, wherein the clamping drive mechanism is fixed to the main body, the plurality of clamping mechanisms are movably connected to the main body, the plurality of clamping mechanisms are connected to the clamping drive mechanism, and the clamping drive mechanism is used to drive the plurality of clamping mechanisms to synchronously clamp or release the sample tube;

[0007] A lifting mechanism, the lifting mechanism is fixedly connected to the main body and is used to output lifting and reciprocating motion to synchronously drive the sample tube rack to rise or fall;

[0008] The ultrasonic mechanism comprises an ultrasonic water tank and an ultrasonic generating assembly, wherein the ultrasonic water tank is arranged below the plurality of the clamping mechanisms, the ultrasonic generating assembly is arranged in the ultrasonic water tank, the ultrasonic water tank is used to store water, and the ultrasonic assembly is used to generate ultrasonic waves;

[0009] The lifting mechanism drives the body to descend, so as to drive the sample tube to move toward the ultrasonic water tank and immerse the sample tube into the water of the ultrasonic water tank, or drives the body to ascend, so as to drive the sample tube to move away from the ultrasonic water tank and leave the ultrasonic water tank.

[0010] As a further solution of the pre-treatment device of the analyzer provided in the present application, the clamping mechanism includes two clamping arms, the clamping drive mechanism includes a sliding guide assembly and a sliding drive assembly, the sliding guide assembly and the sliding drive assembly are both arranged on the main body, the sliding drive assembly is connected to the sliding guide assembly, and is used to drive the sliding guide assembly to output reciprocating motion along the first direction or the second direction; the sliding guide assembly is provided with a plurality of guide parts, and the plurality of guide parts correspond to the plurality of clamping mechanisms one by one; the guide part includes two guide grooves, and the two clamping arms are movably connected to the two guide grooves respectively; the sliding drive assembly drives the sliding guide assembly to slide along the first direction, so that the two clamping arms move respectively along the first ends of the two guide grooves to the second ends and approach each other to clamp the sample tube, or drives the sliding guide assembly to slide along the second direction, so that the two clamping arms move respectively along the second ends of the two guide grooves to the first end and move away from each other to release the sample tube.

[0011] As a further solution of the pre-treatment device of the analyzer provided in the present application, the sliding guide assembly includes a slider, a slide rail and a guide block, the slide rail is arranged on the main body, the slider can be reciprocated and slid on the slide rail along the first direction or the second direction, the guide block is connected to the slider, and the two guide grooves are arranged on the guide block.

[0012] As a further solution of the pre-treatment device of the analyzer provided in the present application, the clamping arm is provided with a clamping groove, and the clamping groove is provided with an anti-slip portion.

[0013] As a further scheme of the pre-processing device of the analyzer provided in the present application, the sliding drive assembly includes a rotational power source, a cam and a connecting member, the rotational power source is fixed to the main body, the cam is connected to the rotating shaft of the rotational power source, the cam is provided with a sliding groove, one end of the connecting member is installed on the slider, and the other end of the connecting member is movably arranged in the sliding groove; the rotational power source drives the cam to rotate a first preset angle along a first rotation direction, and makes the other end of the connecting member slide from the first end of the sliding groove to the second end, thereby driving the slider to slide on the slide rail along the first direction; the rotational power source drives the cam to rotate a second preset angle along a second rotation direction, and makes the other end of the connecting member slide from the second end of the sliding groove to the first end, thereby driving the slider to slide on the slide rail along the second direction.

[0014] As a further solution of the pre-processing device of the analyzer provided in the present application, the lifting mechanism includes a lifting fixed frame, a lifting movable frame and a lifting drive assembly. The lifting movable frame is slidably arranged on the lifting fixed frame in a vertical direction. The lifting drive assembly is fixedly connected to the lifting fixed frame. The lifting drive assembly is transmission-connected to the lifting movable frame. The main body is fixedly connected to the lifting movable frame. The lifting drive assembly is used to drive the lifting movable frame to rise or fall in the vertical direction.

[0015] As a further solution of the pre-processing device of the analyzer provided in the present application, the ultrasonic mechanism also includes a first water level monitoring module and a second water level monitoring module, and the first water level monitoring module and the second water level monitoring module are both arranged in the ultrasonic water tank. The first water level monitoring module is used to monitor whether there is water in the ultrasonic water tank, and the second water level monitoring module is used to detect the water level in the ultrasonic water tank so that the water level is higher than the height of the sample in the sample tube.

[0016] As a further solution of the pre-treatment device of the analyzer provided in the present application, it also includes a liquid adding and discharging mechanism, which is connected to the ultrasonic water tank and is used to add water into the ultrasonic water tank or discharge water from the ultrasonic water tank.

[0017] As a further solution of the pre-treatment device of the analyzer provided in the present application, the liquid adding and discharging mechanism includes an injection pump and a discharge pump, the ultrasonic water tank is provided with an injection port and a discharge port, the injection pump is connected to the injection port, and the discharge pump is connected to the discharge port.

[0018] According to a second aspect of the present application, the present application provides an analyzer, including a pre-processing device of the analyzer.

[0019] According to the analyzer pre-treatment device and analyzer of the above-mentioned embodiment, the ultrasonic wave generated by the ultrasonic wave generating component uses the water in the ultrasonic water tank as the propagation medium, which can prevent the ultrasonic wave generating component from directly contacting the sample tube, thereby preventing the ultrasonic wave from vibrating excessively and breaking the contents of the sample cells. At the same time, the analyzer pre-treatment device can clamp multiple sample tubes through multiple clamping mechanisms, so as to simultaneously perform ultrasonic lysis on the samples in the multiple sample tubes, thereby improving the ultrasonic lysis efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 A three-dimensional diagram of the pre-processing device of the analyzer provided in the present application;

[0021] Figure 2 An exploded view of the pre-processing device of the analyzer provided in this application;

[0022] Figure 3An exploded view of a sample tube rack mechanism in a pre-processing device of an analyzer provided in the present application;

[0023] Figure 4 for Figure 3 A local enlarged schematic diagram of the middle A;

[0024] Figure 5 for Figure 3 A partial enlarged schematic diagram of point B in the middle;

[0025] Figure 6 The three-dimensional structure of the lifting mechanism in the pre-processing device of the analyzer provided in the present application Figure 1 ;

[0026] Figure 7 The three-dimensional structure of the lifting mechanism in the pre-processing device of the analyzer provided in the present application Figure 2 ;

[0027] Figure 8 The ultrasonic mechanism in the pre-processing device of the analyzer provided in this application is a three-dimensional Figure 1 ;

[0028] Fig. 9 The ultrasonic mechanism in the pre-processing device of the analyzer provided in this application is a three-dimensional Figure 2 ;

[0029] Fig.10 A three-dimensional diagram of the liquid-discharging mechanism in the pre-processing device of the analyzer provided in the present application.

[0030] Reference numerals:

[0031] Sample tube rack mechanism 10, sample tube 100, main body 11, multiple clamping mechanisms 12, clamping arm 121, clamping groove 122, anti-slip portion 123, clamping drive mechanism 13, sliding guide assembly 131, guide portion 1311, guide groove 13111, slider 1312, slide rail 1313, guide block 1314, connecting block 1315, sliding drive assembly 132, rotation power source 1321, cam 1322, connecting piece 1323;

[0032] Lifting mechanism 20, lifting fixed frame 21, lifting movable frame 22, lifting drive assembly 23, guide rail 24, guide block 25, lead screw 26;

[0033] Ultrasonic mechanism 30, ultrasonic water tank 31, overflow tank 311, ultrasonic generating assembly 32, first water level monitoring module 33, second water level monitoring module 34, liquid injection port 35, liquid discharge port 36, overflow hole 37;

[0034] Liquid adding and discharging mechanism 40 , liquid filling pump 41 , liquid discharging pump 42 , liquid filling solenoid valve 43 , and liquid discharging solenoid valve 44 . DETAILED DESCRIPTION

[0035] The present application is further described in detail below by specific embodiments in conjunction with the accompanying drawings. Wherein similar elements in different embodiments adopt associated similar element numbers. In the following embodiments, many detailed descriptions are intended to enable the present application to be better understood. However, those skilled in the art can easily recognize that some of the features can be omitted in different situations, or can be replaced by other elements, materials, and methods. In some cases, some operations related to the present application are not shown or described in the specification, in order to avoid the core part of the present application being overwhelmed by too much description, and for those skilled in the art, it is not necessary to describe these related operations in detail, and they can fully understand the related operations based on the description in the specification and the general technical knowledge in the art.

[0036] In addition, the features, operations or characteristics described in the specification can be combined in any appropriate manner to form various implementations, and the operation steps involved in each embodiment can also be replaced or adjusted in a sequence in a manner that is obvious to those skilled in the art. Therefore, the specification and drawings are only for the purpose of clearly describing a certain embodiment and do not mean that the composition and / or sequence are necessary.

[0037] The serial numbers of the components in this document, such as "first", "second", etc., are only used to distinguish the objects described and do not have any order or technical meaning. The "connection" and "coupling" mentioned in this application, unless otherwise specified, include direct and indirect connections (couplings).

[0038] The pre-treatment device of the analyzer can use ultrasonic lysis to lyse and release intracellular substances, such as separating intracellular proteins, extracting genomic DNA or RNA, etc., to study cell metabolic pathways. However, the ultrasonic lysis equipment in the related art mostly directly contacts the sample tube with the ultrasonic probe, which causes the cells to be damaged during the lysis process, and even breaks the nucleic acid fragments, thus affecting downstream detection.

[0039] In view of the above problems, the present application provides a pre-processing device and an analyzer for an analyzer to avoid direct contact of an ultrasonic probe with a sample tube, thereby improving the pass rate of sample pre-processing results and further improving downstream detection efficiency.

[0040] In the following embodiments, a sample tube is filled with a sample, wherein the sample may be blood, body fluid, etc., so that the substance in the sample is extracted or separated by ultrasonic lysis using the pre-treatment device of the analyzer.

[0041] Embodiment 1

[0042] See also Figure 1 and Figure 2As shown, the pre-processing device of the analyzer provided in this embodiment includes a sample tube rack mechanism 10 , a lifting mechanism 20 and an ultrasonic mechanism 30 .

[0043] The sample tube rack mechanism 10 includes a main body 11, a plurality of clamping mechanisms 12 and a clamping drive mechanism 13. The main body 11 is a bearing structure of the sample tube rack mechanism 10. The clamping drive mechanism 13 is fixed to the main body 11. The plurality of clamping mechanisms 12 are movably connected to the main body 11. In other words, each clamping mechanism 12 can move relative to the main body 11, and the plurality of clamping mechanisms 12 are connected to the clamping drive mechanism 13. The clamping drive mechanism 13 is used to drive the plurality of clamping mechanisms 12 to synchronously clamp or release the sample tube 100. Figure 1 and Figure 2 FIG. 8 shows a clamping mechanism 12 clamping a sample tube 100 .

[0044] In this embodiment, the clamping drive mechanism 12 can be driven to enable multiple clamping mechanisms 12 to synchronously clamp the sample tubes 100, and the sample tubes 100 are filled with samples, wherein the samples in each sample tube 100 can be the same or different, or partially the same and partially different. In this way, multiple samples can be ultrasonically lysed at the same time to obtain the contents in the sample cells, thereby improving the lysis efficiency.

[0045] The lifting mechanism 20 is fixedly connected to the main body 11 , and is used to output lifting and reciprocating motions to synchronously drive the sample tube rack 11 to rise or fall.

[0046] The ultrasonic mechanism 30 includes an ultrasonic water tank 31 and an ultrasonic generating assembly 32. The ultrasonic water tank 31 is disposed below the plurality of clamping mechanisms 12, that is, the ultrasonic water tank 31 is located below the plurality of sample tubes 100 clamped by the plurality of clamping mechanisms 12. The ultrasonic generating assembly 32 is disposed in the ultrasonic water tank 32. The ultrasonic water tank 31 is used to store water, and the ultrasonic generating assembly 32 is used to generate ultrasonic waves.

[0047] In this embodiment, a sample is loaded into each sample tube 100, and the clamping drive mechanism 13 drives the plurality of clamping mechanisms 12 to clamp each sample tube 100. After that, the lifting mechanism 20 drives the body 11 to descend, so as to drive the sample tube 100 to move toward the ultrasonic water tank 31, and immerse the sample tube 100 in the water of the ultrasonic water tank 31. At this time, the ultrasonic generating assembly 32 works to generate ultrasonic waves, which last for about 30 minutes. The ultrasonic waves are transmitted to the sample tube 100 with the water in the ultrasonic water tank 31 as the medium, so as to lyse the sample cells in the sample tube 100. At the same time, with the cooling effect of water, ultrasonic lysis is completed by ultrasonic waves. After the above operation is completed, the lifting mechanism 20 drives the body 11 to ascend, so as to drive the sample tube 100 to move away from the ultrasonic water tank 31, and to leave the ultrasonic water tank 31. The sample tube 100 is suspended and the water on the outer tube wall is drained into the ultrasonic water tank 31.

[0048] The ultrasonic wave generated by the ultrasonic wave generating component 32 uses the water in the ultrasonic water tank 31 as a propagation medium, which can prevent the ultrasonic wave generating component 32 from directly contacting the sample tube 100, thereby preventing the ultrasonic wave from vibrating excessively and breaking the contents of the sample cells. At the same time, the pre-treatment device of the analyzer can clamp multiple sample tubes 100 through multiple clamping mechanisms 12, so as to simultaneously perform ultrasonic lysis on the samples in the multiple sample tubes 100, thereby improving the ultrasonic lysis efficiency.

[0049] In one embodiment of the present application, Figure 3 As shown, the sample tube rack mechanism 10 also includes a sliding assembly 14, which is arranged on the main body 11 and can drive the main body 11 to slide. After the ultrasonic lysis of the sample is completed, the clamping mechanism 12 continues to clamp the sample tube 100, and moves the main body 11 under the action of the sliding assembly 14, so that the sample tube 100 can be moved to the corresponding detection position, and the cover of the sample tube 100 is opened to transfer the sample. After the sample transfer is completed, the clamping mechanism 12 releases the sample tube 100 and is taken out by the operator.

[0050] See also Figure 2 As shown, the clamping mechanism 12 includes two clamping arms 121, see Figure 2-Figure 4 As shown, the clamping drive mechanism 13 includes a sliding guide component 131 and a sliding drive component 132, and the sliding guide component 131 and the sliding drive component 132 are both arranged on the main body 11, wherein the sliding guide component 131 can output reciprocating motion along the first direction or the second direction, and the sliding drive component 132 is connected to the sliding guide component 131, and the sliding drive component 132 can be used as a power source for the sliding guide component 131, and the sliding drive component 132 is used to drive the sliding guide component 131 to output reciprocating motion along the first direction or the second direction.

[0051] like Figure 3 and Figure 4 As shown, the sliding guide assembly 131 is provided with a plurality of guide portions 1311, and the plurality of guide portions 131 correspond to the plurality of clamping mechanisms 12. The guide portion 1311 includes two guide grooves 13111, and the two clamping arms 121 are movably connected to the two guide grooves 13111.

[0052] The sliding drive assembly 132 drives the sliding guide assembly 131 to slide along the first direction, so that the two clamping arms 121 move along the first end to the second end of the two guide grooves 13111 respectively, so that the two clamping arms 121 approach each other to clamp the sample tube 100, or the sliding drive assembly 132 drives the sliding guide assembly 131 to slide along the second direction, so that the two clamping arms 121 move along the second end to the first end of the two guide grooves 13111 respectively, so that the two clamping arms 121 move away from each other to release the sample tube 100.

[0053] like Figure 4 As shown, the guide groove 13111 is an inclined groove, and the two clamping arms 121 are respectively connected to the two guide grooves 13111 in a hinged manner. In other words, when the two clamping arms 121 slide along the guide groove 13111, they can rotate around the hinge between them and the guide groove 13111, so that the two clamping arms 121 can approach or move away from each other.

[0054] In a specific embodiment, the two guide grooves 13111 are symmetrically arranged. When the sliding drive assembly 132 drives the sliding guide assembly 131 to output a sliding motion in a first direction, the two clamping arms 121 can move from the first end of the two guide grooves 13111 to the second end, respectively, so that the two clamping arms 121 rotate around the hinges with the respective guide grooves 13111 to approach each other, thereby reducing the distance between the two clamping arms 121 and clamping the sample tube 100. When the sliding drive assembly 132 drives the sliding guide assembly 131 to output a sliding motion in a second direction, the two clamping arms 121 can move from the second end of the two guide grooves 13111 to the first end, respectively, so that the two clamping arms 121 rotate around the hinges with the respective guide grooves 13111 to move away from each other, thereby increasing the distance between the two clamping arms 121 and releasing the sample tube 100. In this way, automatic clamping and releasing of the sample tube 100 is achieved.

[0055] See also Figure 3 and Figure 4As shown, the sliding guide assembly 131 includes a slider 1312, a slide rail 1313 and a guide block 1314. The slide rail 1313 is arranged on the main body 11. The slider 1312 can be reciprocatingly slidably arranged on the slide rail 1313 along the first direction or the second direction. In other words, the first direction and the second direction are overlapping but opposite directions, that is, parallel to the length direction of the slide rail 1313. The guide block 1314 is connected to the slider 1312, and two guide grooves 13111 are arranged on the guide block 1314.

[0056] In this embodiment, when the sliding drive assembly 132 drives the slider 1312 to slide along the slide rail 1313 in the first direction, the guide block 1314 moves synchronously with the slider 1312. During the movement, the two clamping arms 121 can move toward the second end along the first end of the two guide grooves 13111, respectively, so that the two clamping arms 121 rotate around the hinges with their respective guide grooves 13111 to approach each other, thereby reducing the distance between the two clamping arms 121 and clamping the sample tube 100. When the sliding drive assembly 132 drives the slider 1312 to slide along the slide rail 1313 in the second direction, the guide block 1314 moves synchronously with the slider 1312. During the movement, the two clamping arms 121 can move toward the first end along the second end of the two guide grooves 13111, respectively, so that the two clamping arms 121 rotate around the hinges with their respective guide grooves 13111 to move away from each other, thereby increasing the distance between the two clamping arms 121 and releasing the sample tube 100.

[0057] In the present application, eight clamping mechanisms 12 are provided, and the eight clamping mechanisms 12 are equally divided and arranged on opposite sides, thereby reducing the layout space of the clamping mechanisms 12. Among them, two clamping mechanisms 12 are guided by a guide block 1314, so two guide blocks 1314 are provided on each side, and the guide blocks 1314 on the same side are connected to each other through a connecting block 1315 and connected to the slider 1312.

[0058] In order to simplify the structural installation space, the clamping mechanisms 12 located on the opposite sides correspond to each other one by one, and the clamping arms 121 of the two corresponding clamping mechanisms 12 are hingedly connected to each other.

[0059] Continue to see Figure 4 As shown, the clamping arms 121 are provided with clamping grooves 122 . When the two clamping arms 121 clamp the sample tube 100 , the sample tube 100 is clamped in the clamping grooves 122 of the two clamping arms 121 . Accordingly, the shape of the clamping grooves 122 is an arc shape adapted to the sample tube 100 .

[0060] In one embodiment of the present application, the clamping groove 122 is provided with an anti-slip portion 123 to prevent the clamped sample tube 100 from slipping out of the clamping groove 122 .

[0061] In a preferred embodiment, the anti-slip portion 123 is a plurality of equally spaced vertical lines disposed on the clamping groove 122 along the thickness direction of the clamping arm 121. Of course, in other embodiments, the anti-slip portion 123 may also be a plurality of convex points or a plurality of concave points disposed on the clamping groove 122, which can also play an anti-slip role when clamping the sample tube 100.

[0062] like Figure 3 and Figure 5 As shown, the sliding drive assembly 132 includes a rotating power source 1321, a cam 1322 and a connecting member 1323. The rotating power source 1321 is fixed to the main body 11, the cam 1322 is connected to the rotating shaft of the rotating power source 1321, and a sliding groove 13221 is provided on the cam 1322. One end of the connecting member 1322 is installed on the slider 1312, and the other end of the connecting member 1322 is movably arranged in the sliding groove 13221.

[0063] The rotating power source 1321 drives the cam 1322 to rotate a first preset angle along a first rotation direction, and causes the other end of the connecting member 1323 to slide along the first end of the sliding groove 13221 to the second end, thereby driving the slider 1312 to slide on the sliding rail 1313 along the first direction.

[0064] The rotating power source 1321 drives the cam 1322 to rotate a second preset angle along the second rotation direction, and causes the other end of the connecting member 1323 to slide along the second end of the sliding groove 13221 to the first end, thereby driving the slider 1312 to slide on the sliding rail 1313 along the second direction.

[0065] The rotary power source 1321 drives the cam 1322 to rotate by a first preset angle in the first rotation direction, so that the other end of the connecting member 1323 can slide along the first end of the sliding groove 13221 to the second end, and then the slider 1312 can be driven to slide along the first direction on the slide rail 1313 through the connecting member 1323. The rotary power source 1321 drives the cam 1322 to rotate by a second preset angle in the second rotation direction, so that the other end of the connecting member 1323 can slide along the second end of the sliding groove 13221 to the first end, and then the slider 1312 can be driven to slide along the second direction on the slide rail 1313 through the connecting member 1323.

[0066] In this embodiment, the sliding groove 13221 is an arc groove structure arranged with the center of the cam 1322 as the center point, and the first preset rotation angle and the second preset rotation angle can limit the displacement of the slider 1312 sliding on the slide rail 1313.

[0067] See also Figure 6 and Figure 7As shown, the lifting mechanism 20 includes a lifting fixed frame 21, a lifting movable frame 22 and a lifting drive assembly 23. The lifting movable frame 22 is slidably arranged on the lifting fixed frame 21 in the vertical direction. The lifting drive assembly 23 is fixedly connected to the lifting fixed frame 21. The lifting drive assembly 23 is transmission-connected to the lifting movable frame 22. The main body 11 is fixedly connected to the lifting movable frame 21. The lifting drive assembly 23 is used to drive the lifting movable frame 22 to rise or fall in the vertical direction, thereby driving the sample tube 100 clamped on the clamping mechanism 12 to rise or fall.

[0068] In one embodiment of the present application, the lifting fixed frame 21 and the lifting movable frame 22 can be connected by means of a guide rail 24 and a guide block 25, that is, the guide rail 24 is fixed on the lifting fixed frame 21 in a vertical direction, and the guide block 25 is slidably arranged on the guide rail 24, and the lifting movable frame 22 is fixedly connected to the guide block 25. The lifting drive assembly 23 is connected to the lifting movable frame 22 with a lead screw 26 as a transmission structure.

[0069] like Figure 8 As shown, the ultrasonic mechanism 30 also includes a first water level monitoring module 33 and a second water level monitoring module 34. The first water level monitoring module 33 and the second water level monitoring module 34 are both arranged in the ultrasonic water tank 31. The first water level monitoring module 33 is used to monitor whether there is water in the ultrasonic water tank 31, and the second water level monitoring module 34 is used to detect the water level in the ultrasonic water tank 31 so that the water level is higher than the height of the sample in the sample tube 100, but the water level does not completely submerge the sample tube 100.

[0070] like Fig.10 As shown, the pre-treatment device of the analyzer provided in this embodiment further includes a liquid adding and discharging mechanism 40 , which is connected to the ultrasonic water tank 31 and is used to add water into the ultrasonic water tank 31 or to discharge water from the ultrasonic water tank 31 .

[0071] Continue to see Fig.10 As shown, the liquid filling and discharging mechanism 40 includes a liquid filling pump 41 and a liquid discharging pump 42. Fig. 9 As shown, the ultrasonic water tank 31 is provided with an injection port 35 and a discharge port 36, the injection pump 41 is connected to the injection port 35, and the discharge pump 42 is connected to the discharge port 36, so that water is added to the ultrasonic water tank 31 through the injection port 35 under the action of the injection pump 41, and the water in the ultrasonic water tank 31 is discharged through the discharge port 36 under the action of the discharge pump 42.

[0072] In one embodiment of the present application, the liquid adding and discharging mechanism 40 also includes an injection solenoid valve 43 and a discharge solenoid valve 44, wherein the injection solenoid valve 43 is arranged between the injection pump 41 and the injection port 35, and the discharge solenoid valve 44 is arranged between the discharge pump 42 and the injection port 35. The setting of the injection solenoid valve 43 can make the injection pump 41 stop injecting water when the water added to the ultrasonic water tank 31 through the injection port 35 reaches a preset water level. The setting of the discharge solenoid valve 44 can make the discharge pump 42 stop draining water when the water discharged from the ultrasonic water tank 31 through the discharge port 36 is completely drained.

[0073] In a preferred embodiment, the injection solenoid valve 43 is electrically connected to the second water level monitoring module 34. When the second water level monitoring module 34 monitors that the water level in the ultrasonic water tank 31 reaches a preset water level, a control signal can be sent to the injection solenoid valve 43, thereby controlling the injection pump 41 to stop injecting water through the injection solenoid valve 43. The drainage solenoid valve 44 is electrically connected to the first water level monitoring module 33. When the first water level monitoring module 33 monitors that the water in the ultrasonic water tank 31 has been drained, a control signal can be sent to the drainage solenoid valve 44, thereby controlling the drainage pump 42 to stop draining water through the drainage solenoid valve 44.

[0074] In this embodiment, when the lifting mechanism 20 drives the main body 11 to descend so that the sample tube 100 is immersed in the water in the ultrasonic water tank 31, part of the water will overflow. Figure 8 and Fig. 9 As shown, an overflow groove 311 is also provided on the side edge of the ultrasonic water tank 31. The overflow groove 311 is arranged around the side edge of the ultrasonic water tank 31, and the overflowed water flows into the overflow groove 311 to avoid affecting the device.

[0075] In one embodiment, the ultrasonic water tank 31 is further provided with an overflow hole 37 . The overflow hole 37 is specifically arranged below the overflow tank 311 . The overflow hole 37 is used to discharge the water in the overflow tank 311 .

[0076] Embodiment 2

[0077] This embodiment further provides an analyzer, including the pre-processing device of the analyzer in the first embodiment. For the structural features and working principle of the pre-processing device of the analyzer, please refer to the above embodiment and will not be repeated here.

[0078] In summary, in the pre-treatment device and analyzer provided by the present application, the ultrasonic wave generated by the ultrasonic wave generating component uses the water in the ultrasonic water tank as the propagation medium, which can prevent the ultrasonic wave generating component from directly contacting the sample tube, thereby preventing the ultrasonic wave from vibrating excessively and breaking the contents of the sample cells. At the same time, the pre-treatment device of the analyzer can clamp multiple sample tubes through multiple clamping mechanisms, so as to simultaneously perform ultrasonic lysis on the samples in the multiple sample tubes, thereby improving the efficiency of ultrasonic lysis.

[0079] The above specific examples are used to illustrate the present invention, which is only used to help understand the present invention and is not intended to limit the present invention. For those skilled in the art, according to the concept of the present invention, some simple deductions, modifications or substitutions can be made.

Claims

1. A pre-processing device for an analyzer, It is characterized in that include: The sample tube rack mechanism comprises a main body, a plurality of clamping mechanisms and a clamping drive mechanism, wherein the clamping drive mechanism is fixed to the main body, the plurality of clamping mechanisms are movably connected to the main body, the plurality of clamping mechanisms are connected to the clamping drive mechanism, and the clamping drive mechanism is used to drive the plurality of clamping mechanisms to synchronously clamp or release the sample tube; A lifting mechanism, the lifting mechanism is fixedly connected to the main body and is used to output lifting and reciprocating motion to synchronously drive the sample tube rack to rise or fall; The ultrasonic mechanism comprises an ultrasonic water tank and an ultrasonic generating assembly, wherein the ultrasonic water tank is arranged below the plurality of the clamping mechanisms, the ultrasonic generating assembly is arranged in the ultrasonic water tank, the ultrasonic water tank is used to store water, and the ultrasonic assembly is used to generate ultrasonic waves; The lifting mechanism drives the body to descend, so as to drive the sample tube to move toward the ultrasonic water tank and immerse the sample tube into the water of the ultrasonic water tank, or drives the body to ascend, so as to drive the sample tube to move away from the ultrasonic water tank and leave the ultrasonic water tank.

2. The pre-processing device of the analyzer according to claim 1, It is characterized in that The clamping mechanism includes two clamping arms, and the clamping drive mechanism includes a sliding guide assembly and a sliding drive assembly, both of which are arranged on the main body, and the sliding drive assembly is connected to the sliding guide assembly to drive the sliding guide assembly to output reciprocating motion along the first direction or the second direction; a plurality of guide parts are provided on the sliding guide assembly, and the plurality of guide parts correspond to the plurality of clamping mechanisms one by one; the guide part includes two guide grooves, and the two clamping arms are movably connected to the two guide grooves respectively; the sliding drive assembly drives the sliding guide assembly to slide along the first direction, so that the two clamping arms move respectively along the first ends of the two guide grooves to the second ends and approach each other to clamp the sample tube, or drives the sliding guide assembly to slide along the second direction, so that the two clamping arms move respectively along the second ends of the two guide grooves to the first end and move away from each other to release the sample tube.

3. The pre-processing device of the analyzer according to claim 2, It is characterized in that The sliding guide assembly includes a slider, a slide rail and a guide block. The slide rail is arranged on the main body. The slider can be reciprocated and slidably arranged on the slide rail along a first direction or a second direction. The guide block is connected to the slider, and the two guide grooves are arranged on the guide block.

4. The pre-processing device of the analyzer according to claim 3, It is characterized in that The clamping arm is provided with a clamping groove, and the clamping groove is provided with an anti-slip portion.

5. The pre-processing device of the analyzer according to claim 2, It is characterized in that The sliding drive assembly includes a rotating power source, a cam and a connecting member, the rotating power source is fixed to the main body, the cam is connected to the rotating shaft of the rotating power source, the cam is provided with a sliding groove, one end of the connecting member is installed on the slider, and the other end of the connecting member is movably arranged in the sliding groove; the rotating power source drives the cam to rotate a first preset angle along a first rotation direction, and makes the other end of the connecting member slide along the first end of the sliding groove to the second end, thereby driving the slider to slide along the first direction on the slide rail; the rotating power source drives the cam to rotate a second preset angle along the second rotation direction, and makes the other end of the connecting member slide along the second end of the sliding groove to the first end, thereby driving the slider to slide along the second direction on the slide rail.

6. The pre-processing device of the analyzer according to claim 1, It is characterized in that The lifting mechanism includes a lifting fixed frame, a lifting movable frame and a lifting drive assembly. The lifting movable frame is slidably arranged on the lifting fixed frame in a vertical direction. The lifting drive assembly is fixedly connected to the lifting fixed frame. The lifting drive assembly is transmission-connected to the lifting movable frame. The main body is fixedly connected to the lifting movable frame. The lifting drive assembly is used to drive the lifting movable frame to rise or fall in the vertical direction.

7. The pre-processing device of the analyzer according to claim 1, It is characterized in that The ultrasonic mechanism also includes a first water level monitoring module and a second water level monitoring module. The first water level monitoring module and the second water level monitoring module are both arranged in the ultrasonic water tank. The first water level monitoring module is used to monitor whether there is water in the ultrasonic water tank, and the second water level monitoring module is used to detect the water level in the ultrasonic water tank so that the water level is higher than the height of the sample in the sample tube.

8. The pre-processing device of the analyzer according to claim 1, It is characterized in that It also includes a liquid adding and discharging mechanism, which is connected to the ultrasonic water tank and is used to add water into the ultrasonic water tank or discharge water from the ultrasonic water tank.

9. The pre-processing device of the analyzer according to claim 8, It is characterized in that The liquid adding and discharging mechanism comprises a liquid injection pump and a liquid discharge pump. The ultrasonic water tank is provided with a liquid injection port and a liquid discharge port. The liquid injection pump is communicated with the liquid injection port, and the liquid discharge pump is communicated with the liquid discharge port.

10. An analyzer, It is characterized in that The invention comprises a pre-processing device of an analyzer as described in any one of claims 1 to 9.

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