Oral insulin preparation, preparation method and preparation device

Abstract

The invention discloses an oral insulin preparation, a preparation method and a preparation device. The oral insulin preparation comprises a machine body, an air heater is fixedly installed on the right side of the machine body, a material collector is fixedly installed on the left side of the machine body, a bent pipe is fixedly communicated between the material collector and the machine body, and a material pump is fixedly installed in the middle of the top end of the machine body. Through the arrangement of the rack, the frame, the square pipe and the spray head, during use, hot air generated by the hot air blower is conveyed into the square pipe through the hose and finally sprayed out through the spray head, the driving mechanism can enable the straight gear to drive the frame to reciprocate up and down, and meanwhile due to the design of the rack, the straight gear and the frame can rotate in a small range when moving up and down; and under the action of the shaking mechanism, the spray head can swing left and right, so that the spray head sprays hot air to different positions, and disordered airflow is formed in the machine body. The insulin premixing liquid drying device has the advantage that the drying effect on the insulin premixing liquid is improved by spraying hot air to different positions.

Description

Technical Field

[0001] The present invention belongs to the field of biomedicine technology, and in particular relates to an oral insulin preparation, a preparation method and a preparation device. Background Art

[0002] As we all know, insulin is one of the most important endocrine hormones in the body and is a regulatory substance necessary to maintain normal sugar metabolism. Lack of insulin in the human body will lead to increased blood sugar, so diabetic patients usually need to use exogenous insulin for treatment. Currently, people can also make insulin into oral medications, which can effectively release insulin after oral administration, reducing the inconvenience and side effects of injection. In the process of making oral medications, workers need to use a variety of pharmaceutical equipment, including a spray dryer, which sprays the insulin premix into hot air to dry it into tiny particles, thereby obtaining an insulin solid dispersion.

[0003] However, there are some problems with the prior art: although the existing spray dryer can obtain insulin solid dispersion from insulin premix, in actual use, the hot air in the existing spray dryer is usually directly introduced from the nozzle on the top of the body, and the nozzle usually sprays hot air downward, and the direction of the jet is fixed and the same as the spray direction of the insulin premix, which makes it difficult for the sprayed insulin premix to contact with a large area of ​​hot air in a short time, thereby reducing the drying effect, making it difficult for the quality of the produced product to meet the requirements. Therefore, we propose an oral insulin preparation, a preparation method, and a preparation device. Summary of the invention

[0004] In view of the problems existing in the prior art, the purpose of the present invention is to provide an oral insulin preparation, a preparation method and a preparation device, which can improve the drying effect of the insulin premix by allowing hot air to be sprayed to different positions.

[0005] The present invention is achieved by an oral insulin preparation comprising: an active ingredient; the active ingredient is composed of one or more of insulin and its biologically active derivatives;

[0006] Protective agent; the protective agent is composed of one or more of polyvinyl pyrrolidone PVP, polyethylene glycol chitosan PEG-CS, and phospholipids;

[0007] Carrier; the carrier is composed of a polymer nanomaterial, and the polymer nanomaterial is a porous, acid-resistant metal organic framework component;

[0008] Protective layer; the protective layer is composed of the outer surface of the targeted protein modified nanomaterial;

[0009] Sustained-release layer: The sustained-release layer is added outside the protective layer to achieve the slow release of insulin in the intestine.

[0010] A method for preparing an oral insulin preparation,

[0011] S1. Mixing insulin powder or its biologically active derivative with an appropriate amount of protective agent in a certain proportion, and stirring to form a nanoscale insulin complex;

[0012] S2, adding the insulin complex solution prepared in S1 to an appropriate amount of water for injection or physiological saline, adjusting the concentration to a suitable concentration, and obtaining an insulin premix solution;

[0013] S3, encapsulating the insulin premix solution into a carrier to construct an insulin nanomaterial;

[0014] S4, using a targeted protein to modify the outer surface of the insulin nanomaterial, wrapping the insulin nanomaterial to form a protective layer, and then adding a sustained-release layer outside the protective layer to obtain a modified insulin premix;

[0015] S5, spraying the modified insulin premix into hot air, drying to form particles, and obtaining an insulin solid dispersion;

[0016] S6. Mix the insulin solid dispersion with excipients, press into tablets or fill into capsule shells to obtain an oral insulin preparation.

[0017] A device for preparing an oral insulin preparation comprises a body, a hot air blower is fixedly installed on the right side of the body, a material collector is fixedly installed on the left side of the body, a curved pipe is fixedly connected between the material collector and the body, a material pump is fixedly installed in the middle of the top of the body, an output pipe of the material pump extends to the inside of the body and is rotatably connected to a nozzle, the bottom of the nozzle is inclined, a frame is arranged inside the body, a shaking mechanism is arranged on the frame, square tubes are fixedly installed on both sides of the bottom of the frame, a hose is fixedly connected between the square tube and the hot air blower, a nozzle is rotatably connected to the top of the square tube, and the nozzle swings through the shaking mechanism, racks are fixedly installed on both sides of the inner wall of the body, spur gears are fixedly installed on both sides of the frame, the spur gears are meshingly connected to the racks, and the spur gears are connected to the body through a driving mechanism.

[0018] Optionally, the driving mechanism includes a driving motor, which is fixedly installed on the top of the machine body, and the output shaft of the driving motor is fixedly sleeved with a rotating shaft, the bottom end of the rotating shaft extends to the interior of the machine body and is fixedly connected with a driving gear, the outer surface of the nozzle is fixedly sleeved with a driven gear, the driven gear is meshingly connected with the driving gear, and the top of the outer surface of the rotating shaft is fixedly sleeved with a first pulley.

[0019] Optionally, both sides of the top of the machine body are rotatably connected with second pulleys, a belt is transmission-connected between the second pulley and the first pulley, and the top of the second pulley is fixedly connected with a first bevel gear.

[0020] Optionally, vertical rods are movably inserted on both sides of the top of the body, the bottoms of the vertical rods extend into the interior of the body, the spur gears are rotatably connected to the vertical rods, and a square frame located above the body is fixedly installed on the vertical rods.

[0021] Optionally, vertical plates are fixedly installed on both sides of the top of the machine body, and a circular shaft is rotatably connected to the vertical plate. One end of the circular shaft is fixedly connected to a second bevel gear, and the second bevel gear is meshingly connected to the first bevel gear. The other end of the circular shaft is fixedly connected to a rocker arm, and the first round block located inside the square frame is fixedly installed on the rocker arm.

[0022] Optionally, a wave plate is fixedly installed on the left side of the inner wall of the machine body, and the shaking mechanism includes a guide rod, which is movably plugged into the frame, and a cross plate is fixedly connected to the guide rod, and a through hole is opened on the cross plate above the nozzle, and a second round block located inside the through hole is fixedly connected to the top of the nozzle.

[0023] Optionally, a ball is movably mounted on one end of the guide rod away from the cross plate, and the ball is slidably connected to the surface of the wave plate.

[0024] Optionally, a spring located between the frame and the cross plate is movably sleeved on the outer surface of the guide rod, and two ends of the spring are respectively fixedly connected to the frame and the cross plate.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] 1. The present invention is provided with a rack, a spur gear, a frame, a square tube and a nozzle. When in use, the hot air generated by the hot air blower is transported to the inside of the square tube through a hose and finally sprayed out by the nozzle. The staff can start the driving mechanism to make the spur gear drive the frame to reciprocate up and down. At the same time, due to the design of the rack, the spur gear and the frame can rotate slightly when moving up and down, and under the action of the shaking mechanism, the nozzle can also swing left and right, so that the nozzle sprays the hot air to different positions, forming a turbulent airflow in the body, thereby increasing the contact area between the insulin premix and the hot air, thereby improving the drying effect of the insulin premix.

[0027] 2. The present invention is provided with a driving motor, a driving gear, a driven gear and a nozzle. After the insulin premix is ​​drawn by the material pump, it is transported to the inside of the nozzle and then sprayed out. By starting the driving motor, the rotating shaft can drive the driving gear to rotate, so that the driven gear can drive the nozzle to rotate together. Since the bottom of the nozzle is inclined, the spraying range can be increased when the insulin premix is ​​rotated to spray, so that the insulin premix is ​​more dispersed, thereby improving the subsequent drying efficiency.

[0028] 3. The present invention sets a wave plate and a ball. When the frame drives the guide rod to move, the ball will always keep in contact with the wave plate under the elastic force of the spring, so that the guide rod and the cross plate can reciprocate. The design of the ball can avoid direct contact between the guide rod and the wave plate. The rolling of the ball along the surface of the wave plate can reduce the wear on the wave plate and be more stable, thereby improving the service life of the device.

[0029] Further features and advantages of the present invention will become apparent from the following detailed description of exemplary embodiments of the present invention with reference to the attached drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] FIG1 is a schematic diagram of the structure provided by the present invention;

[0031] FIG2 is a schematic diagram of the side structure provided by the present invention;

[0032] FIG3 is a schematic diagram of the top structure provided by the present invention;

[0033] FIG4 is a front cross-sectional view of the structure provided by the present invention;

[0034] FIG5 is a schematic diagram of a side partial cross-sectional structure provided by the present invention;

[0035] FIG6 is a schematic diagram of the structure of the framework provided by the present invention;

[0036] FIG7 is a schematic structural diagram of the top of the nozzle provided by the present invention;

[0037] FIG8 is a schematic diagram of a partial enlarged structure of point A in FIG4;

[0038] FIG9 is a schematic diagram of a partial enlarged structure of point B in FIG6;

[0039] FIG. 10 is a schematic diagram of a partially enlarged structure of point C in FIG. 6 .

[0040] In the figure: 1, machine body; 2, material pump; 3, nozzle; 4, frame; 5, square tube; 6, nozzle; 7, rack; 8, spur gear; 9, driving motor; 10, rotating shaft; 11, driving gear; 12, driven gear; 13, first pulley; 14, second pulley; 15, belt; 16, first bevel gear; 17, vertical rod; 18, square frame; 19, vertical plate; 20, round shaft; 21, second bevel gear; 22, rocker rod; 23, first round block; 24, wave plate; 25, guide rod; 26, horizontal plate; 27, through hole; 28, second round block; 29, spring; 30, ball; 31, hot air blower; 32, hose; 33, collector; 34, elbow. DETAILED DESCRIPTION

[0041] In order to further understand the content, features and effects of the present invention, the following embodiments are given as examples and described in detail with reference to the accompanying drawings.

[0042] Various exemplary embodiments of the present invention will now be described in detail with reference to the accompanying drawings. It should be noted that the relative arrangement of components and steps, numerical expressions and numerical values ​​set forth in these embodiments do not limit the scope of the present invention unless otherwise specifically stated.

[0043] The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the invention, its application, or uses.

[0044] Technologies, methods, and equipment known to ordinary technicians in the relevant art may not be discussed in detail, but where appropriate, the technologies, methods, and equipment should be considered as part of the specification.

[0045] In all examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not limiting. Therefore, other examples of the exemplary embodiments may have different values.

[0046] The structure of the present invention is described in detail below in conjunction with the accompanying drawings.

[0047] As shown in FIG. 1 to FIG. 10 , an oral insulin preparation, a preparation method, and a preparation device provided by an embodiment of the present invention, wherein an oral insulin preparation comprises: selecting insulin or a biologically active derivative thereof as an active ingredient;

[0048] A porous, acid-resistant metal organic framework polymer nanomaterial is selected as a carrier. This material can effectively encapsulate insulin and protect it from digestive enzymes, which significantly improves the stability of insulin in the preparation and can resist the acidity and enzymatic hydrolysis in the gastrointestinal environment.

[0049] Using targeted proteins to modify the outer surface of nanomaterials as a protective layer can enhance their stability and targeting in the intestines, and is used to prevent insulin from denaturing in the stomach acid environment, thereby improving the oral absorption rate of insulin;

[0050] Control the physical and chemical properties of the preparation, such as particle size and surface charge, to adapt to the environment of the human gastrointestinal tract and ensure that insulin can be effectively released after oral administration;

[0051] A sustained-release layer used to control the release rate of insulin in the intestine to achieve better therapeutic effects.

[0052] According to existing research, chitosan, amphiphilic micelles, nanoparticles, etc. are all potential insulin carrier materials. Among them, chitosan, due to its good biocompatibility and biodegradability, can effectively encapsulate and protect insulin from being destroyed by enzymes in the gastrointestinal tract. It also has good biocompatibility and permeability, ensuring that insulin can smoothly pass through the gastrointestinal tract to reach the intestinal tract. Therefore, it is widely used in oral insulin delivery systems.

[0053] The present invention also provides a method for preparing the preparation, comprising the following steps:

[0054] S1. Mix insulin powder or its biologically active derivatives with an appropriate amount of protective agent (such as polyvinyl pyrrolidone PVP, polyethylene glycol chitosan PEG-CS, phospholipids, etc.) in a certain proportion by chemical or physical methods, and stir them thoroughly to make them evenly dispersed to form a nano-scale insulin complex. This step can be done by covalent coupling or ion gel method to ensure stable binding between insulin and the carrier.

[0055] S2. Prepare insulin premix solution: add the mixed insulin and protective agent solution into an appropriate amount of water for injection or physiological saline using physical methods such as ultrasound or microwave, adjust the concentration to a suitable concentration, and obtain insulin premix solution.

[0056] S3. Encapsulate the treated insulin premix solution into a porous, acid-resistant metal-organic framework nanomaterial to construct a nanosystem with insulin protection and intestinal transport functions.

[0057] S4. Use targeted proteins to modify the outer surface of nanomaterials to enhance their stability in the intestine and promote the effective release of insulin. Then wrap a protective layer outside the nanosystem, which can resist the erosion of gastric acid while allowing insulin to pass through the stomach into the small intestine. Finally, add a sustained-release layer outside the protective layer, such as chitosan nanoparticles, to achieve slow release of insulin in the intestine. We get the further modified insulin premix we need.

[0058] S5. Spray drying of insulin premix: Using spray drying technology, the insulin premix obtained after further processing is sprayed into hot air, so that it is quickly dried to form tiny particles to obtain insulin solid dispersion; the design of insulin solid dispersion helps its dissolution and absorption in the gastrointestinal tract, thereby improving the bioavailability of insulin.

[0059] S6. Preparation of oral insulin pharmaceutical preparations: Mix the insulin solid dispersion with an appropriate amount of excipients (such as starch, lactose, microcrystalline cellulose, etc.), press into tablets or fill into capsule shells to obtain oral insulin preparations.

[0060] The present invention also provides a device for spray drying the insulin premix in the above step S5: a preparation device for oral insulin preparation, comprising a body 1, a hot air blower 31 is fixedly installed on the right side of the body 1, a material collector 33 is fixedly installed on the left side of the body 1, a curved pipe 34 is fixedly connected between the material collector 33 and the body 1, a material pump 2 is fixedly installed in the middle of the top of the body 1, the output pipe of the material pump 2 extends to the inside of the body 1 and is rotatably connected to a nozzle 3, the bottom of the nozzle 3 is inclined, a frame 4 is arranged inside the body 1, a shaking mechanism is arranged on the frame 4, square tubes 5 are fixedly installed on both sides of the bottom of the frame 4, a hose 32 is fixedly connected between the square tube 5 and the hot air blower 31, a nozzle 6 is rotatably connected to the top of the square tube 5, and the nozzle 6 swings through the shaking mechanism, racks 7 are fixedly installed on both sides of the inner wall of the body 1, spur gears 8 are fixedly installed on both sides of the frame 4, the spur gear 8 is meshed with the rack 7, and the spur gear 8 is connected to the body 1 through a driving mechanism.

[0061] Furthermore, the driving mechanism includes a driving motor 9, which is fixedly installed on the top of the body 1. The output shaft of the driving motor 9 is fixedly sleeved with a rotating shaft 10. The bottom end of the rotating shaft 10 extends to the inside of the body 1 and is fixedly connected with a driving gear 11. The outer surface of the nozzle 3 is fixedly sleeved with a driven gear 12, and the driven gear 12 is meshingly connected with the driving gear 11. The top of the outer surface of the rotating shaft 10 is fixedly sleeved with a first pulley 13.

[0062] By starting the driving motor 9, the rotating shaft 10 can drive the driving gear 11 to rotate, thereby driving the driven gear 12 and the nozzle 3 to rotate together. Since the bottom of the nozzle 3 is inclined, the spraying range can be increased when spraying the insulin premix, making the insulin premix more dispersed, thereby improving the subsequent drying efficiency.

[0063] Furthermore, both sides of the top of the machine body 1 are rotatably connected with second pulleys 14 , a belt 15 is transmission-connected between the second pulley 14 and the first pulley 13 , and a first bevel gear 16 is fixedly connected to the top of the second pulley 14 .

[0064] When the rotating shaft 10 drives the first pulley 13 to rotate, the second pulley 14 is driven to rotate through the belt 15, thereby driving the first bevel gear 16 to rotate together.

[0065] Furthermore, vertical rods 17 are movably inserted on both sides of the top of the body 1, and the bottom of the vertical rods 17 extends to the inside of the body 1. The spur gear 8 is rotatably connected to the vertical rods 17, and a square frame 18 located above the body 1 is fixedly installed on the vertical rods 17.

[0066] When the vertical rod 17 moves upward or downward, it will drive the spur gear 8 and the frame 4 to move together. At the same time, due to the meshing connection between the spur gear 8 and the rack 7, the spur gear 8 and the frame 4 will also rotate when moving upward or downward, thereby enabling the nozzle 6 to spray hot air at different positions in the vertical direction.

[0067] Furthermore, vertical plates 19 are fixedly installed on both sides of the top of the body 1, and a circular shaft 20 is rotatably connected to the vertical plate 19. One end of the circular shaft 20 is fixedly connected to a second bevel gear 21, and the second bevel gear 21 is meshingly connected to the first bevel gear 16. The other end of the circular shaft 20 is fixedly connected to a swing rod 22, and a first round block 23 located inside the square frame 18 is fixedly installed on the swing rod 22.

[0068] When the first bevel gear 16 rotates, the second bevel gear 21 can drive the circular shaft 20, the rocker arm 22 and the first circular block 23 to rotate together, so that the outer surface of the first circular block 23 can press the inner wall of the square frame 18, and then the square frame 18 can drive the vertical rod 17 to reciprocate up and down.

[0069] Furthermore, a wave plate 24 is fixedly installed on the left side of the inner wall of the body 1, and the shaking mechanism includes a guide rod 25, which is movably inserted into the frame 4, and a cross plate 26 is fixedly connected to the guide rod 25. The cross plate 26 is provided with a through hole 27 located above the nozzle 6, and the top of the nozzle 6 is fixedly connected to a second round block 28 located inside the through hole 27.

[0070] When the frame 4 drives the guide rod 25 to move, the guide rod 25 will drive the cross plate 26 to move along the axial direction of the guide rod 25 under the influence of the wave plate 24, so that the inner wall of the through hole 27 can squeeze the second round block 28, and then the nozzle 6 can rotate, so that the nozzle 6 can spray hot air at different positions in the horizontal direction.

[0071] Furthermore, a ball 30 is movably mounted on one end of the guide rod 25 away from the transverse plate 26 , and the ball 30 is slidably connected to the surface of the wave plate 24 .

[0072] The design of the ball bearing 30 can prevent the guide rod 25 from directly contacting the wave plate 24 . The ball bearing 30 rolling along the surface of the wave plate 24 can reduce the wear on the wave plate 24 and provide greater stability.

[0073] Furthermore, a spring 29 located between the frame 4 and the cross plate 26 is movably sleeved on the outer surface of the guide rod 25 , and two ends of the spring 29 are fixedly connected to the frame 4 and the cross plate 26 respectively.

[0074] Due to the elastic force of the spring 29 , the ball 30 will always keep in contact with the wave plate 24 , so that when the ball 30 moves along the surface of the wave plate 24 , it can drive the cross plate 26 to reciprocate through the guide rod 25 .

[0075] Working principle and use process of the preparation device:

[0076] During use, the staff connects an external water pipe to the input pipe of the material pump 2 to the insulin premix, and then starts the material pump 2, the hot air blower 31 and the collector 33. The insulin premix is ​​extracted by the material pump 2, and transported from the output pipe on the material pump 2 to the inside of the nozzle 3 for spraying. The hot air generated by the hot air blower 31 is transported to the inside of the square tube 5 through the hose 32 and finally sprayed out from the nozzle 6. At the same time, the staff can start the driving motor 9. Due to the operation of the driving motor 9, the rotating shaft 10 can drive the driving gear 11 and the first pulley 13 to rotate, so that the driven gear 12 can drive the nozzle 3 to rotate together. Since the bottom of the nozzle 3 is inclined, the spraying range can be increased when the insulin premix is ​​rotated to spray, so that the insulin premix is ​​more dispersed, thereby improving the subsequent drying efficiency.

[0077] At the same time, due to the rotation of the first pulley 13, the second pulley 14 will be driven to rotate through the belt 15, so that the first bevel gear 16 can drive the second bevel gear 21 to rotate, and then the circular shaft 20 can drive the rocker arm 22 and the first round block 23 to rotate together. Due to the rotation of the first round block 23, the inner wall of the square frame 18 will be squeezed, so that the square frame 18 drives the vertical rod 17 to reciprocate up and down, so that the spur gear 8 and the frame 4 can reciprocate up and down, and due to the design of the rack 7, the spur gear 8 will also rotate slightly in the process of driving the frame 4 to move up and down, so as to change the direction of the hot air sprayed by the nozzle 6 in the vertical position.

[0078] During the movement of the frame 4, due to the elastic force of the spring 29, the ball 30 will always maintain contact with the wave plate 24, so that the guide rod 25 and the cross plate 26 can reciprocate. Due to the movement of the cross plate 26, the inner wall of the through hole 27 will squeeze the outer surface of the second round block 28, so that the nozzle 6 can reciprocate, and then the direction of the hot air sprayed by the nozzle 6 in the horizontal position can be changed. In summary, the nozzle 6 can spray hot air to different positions, forming a turbulent airflow in the body 1, and then the contact area between the insulin premix and the hot air can be increased, thereby improving the drying effect of the insulin premix. Finally, the insulin solid dispersion is sent from the bend 34 to the collector 33 for collection, and the preparation of the insulin solid dispersion is completed.

[0079] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0080] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An oral insulin preparation, characterized in that: include: Active ingredient; the active ingredient is composed of one or more of insulin and its biologically active derivatives; Protective agent; the protective agent is composed of one or more of polyvinylpyrrolidone PVP, polyethylene glycol chitosan PEG-CS, and phospholipids; Carrier; the carrier is composed of a polymer nanomaterial, and the polymer nanomaterial is a porous, acid-resistant metal organic framework component; Protective layer; the protective layer is composed of the outer surface of the targeted protein modified nanomaterial; Sustained-release layer: The sustained-release layer is added outside the protective layer to achieve slow release of insulin in the intestine.

2. A method for preparing an oral insulin preparation, characterized in that: S1. Mixing insulin powder or its biologically active derivative with an appropriate amount of a protective agent in a certain proportion, and stirring to form a nanoscale insulin complex; S2. Add the insulin complex solution prepared in S1 to an appropriate amount of water for injection or normal saline, and adjust the concentration to an appropriate concentration to obtain an insulin premix solution; S3, encapsulating the insulin premix solution into a carrier to form an insulin nanomaterial; S4. Modifying the outer surface of the insulin nanomaterial with a targeted protein to form a protective layer around the insulin nanomaterial, and then adding a sustained-release layer outside the protective layer to obtain a modified insulin premix solution; S5, spraying the modified insulin premix into hot air, drying to form particles, and obtaining an insulin solid dispersion; S6. Mix the insulin solid dispersion with excipients, compress it into tablets or fill it into capsule shells to obtain an oral insulin preparation.

3. A device for preparing an oral insulin preparation, comprising a body (1), a hot air blower (31) fixedly mounted on the right side of the body (1), a material collector (33) fixedly mounted on the left side of the body (1), a curved pipe (34) fixedly connected between the material collector (33) and the body (1), characterized in that: A material pump (2) is fixedly installed in the middle of the top of the body (1), and the output pipe of the material pump (2) extends into the interior of the body (1) and is rotatably connected to a nozzle (3), the bottom of the nozzle (3) is inclined, and a frame (4) is provided inside the body (1), and a shaking mechanism is provided on the frame (4). Square tubes (5) are fixedly installed on both sides of the bottom of the frame (4), and a hose (32) is fixedly connected between the square tube (5) and the hot air blower (31). The top of the square tube (5) is rotatably connected to a nozzle (6), and the nozzle (6) swings through the shaking mechanism. Racks (7) are fixedly installed on both sides of the inner wall of the body (1), and spur gears (8) are fixedly installed on both sides of the frame (4). The spur gear (8) is meshed with the rack (7), and the spur gear (8) is connected to the body (1) through a driving mechanism.

4. The device for preparing an oral insulin preparation according to claim 3, characterized in that: The driving mechanism comprises a driving motor (9), the driving motor (9) being fixedly mounted on the top of the machine body (1), the output shaft of the driving motor (9) being fixedly sleeved with a rotating shaft (10), the bottom end of the rotating shaft (10) extending into the interior of the machine body (1) and being fixedly connected with a driving gear (11), the outer surface of the nozzle (3) being fixedly sleeved with a driven gear (12), the driven gear (12) being meshedly connected with the driving gear (11), and the top of the outer surface of the rotating shaft (10) being fixedly sleeved with a first pulley (13).

5. The device for preparing an oral insulin preparation according to claim 3, characterized in that: Both sides of the top of the machine body (1) are rotatably connected to second pulleys (14), a belt (15) is transmission-connected between the second pulley (14) and the first pulley (13), and a first bevel gear (16) is fixedly connected to the top of the second pulley (14).

6. The device for preparing an oral insulin preparation according to claim 3, characterized in that: Vertical rods (17) are movably connected to both sides of the top of the machine body (1), and the bottom of the vertical rods (17) extends to the interior of the machine body (1). The spur gear (8) is rotatably connected to the vertical rods (17), and a square frame (18) located above the machine body (1) is fixedly installed on the vertical rods (17).

7. The device for preparing an oral insulin preparation according to claim 3, characterized in that: Vertical plates (19) are fixedly mounted on both sides of the top of the machine body (1), and a circular shaft (20) is rotatably connected to the vertical plate (19). One end of the circular shaft (20) is fixedly connected to a second bevel gear (21), and the second bevel gear (21) is meshingly connected to the first bevel gear (16). The other end of the circular shaft (20) is fixedly connected to a swing rod (22), and a first round block (23) located inside the square frame (18) is fixedly mounted on the swing rod (22).

8. The device for preparing an oral insulin preparation according to claim 3, characterized in that: A wave plate (24) is fixedly installed on the left side of the inner wall of the body (1), and the shaking mechanism includes a guide rod (25), which is movably plugged into the frame (4), and a transverse plate (26) is fixedly connected to the guide rod (25), and a through hole (27) located above the nozzle (6) is opened on the transverse plate (26), and a second round block (28) located inside the through hole (27) is fixedly connected to the top of the nozzle (6).

9. The device for preparing an oral insulin preparation according to claim 8, characterized in that: A ball (30) is movably mounted on one end of the guide rod (25) away from the transverse plate (26), and the ball (30) is slidably connected to the surface of the wave plate (24).

10. The device for preparing an oral insulin preparation according to claim 8, characterized in that: The outer surface of the guide rod (25) is movably sleeved with a spring (29) located between the frame (4) and the transverse plate (26), and both ends of the spring (29) are fixedly connected to the frame (4) and the transverse plate (26) respectively.

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