Antibacterial fabric, preparation method thereof and dressing

Abstract

The invention relates to the technical field of medical supplies, in particular to an antibacterial fabric and a preparation method and dressing thereof, and the preparation method comprises the following steps: performing carboxymethylation treatment on an original fabric to obtain a carboxymethylated fabric; performing cross-linking grafting treatment on the carboxymethylated fabric through an inclusion agent and a cross-linking agent to obtain a grafted fabric; and soaking the grafted fabric in an antibacterial solution to obtain the antibacterial fabric. According to the preparation method of the antibacterial fabric provided by the invention, the original fabric is firstly subjected to carboxymethylation treatment, and then is subjected to cross-linking grafting treatment, so that the strength and the flexibility of the fabric are improved while an inclusion agent is grafted to the fabric; and finally, the antibacterial substances are clathrated by the clathration agent through dipping, so that the prepared antibacterial fabric has high liquid absorbency, high strength and flexibility, meanwhile, the antibacterial substances in the antibacterial fabric are not easy to quickly fall off, and the stability and durability of the antibacterial property are improved while the safety is improved.

Description

Technical Field

[0001] The invention relates to the technical field of medical supplies, and in particular to an antibacterial fabric and a preparation method and a dressing thereof. Background Art

[0002] Sodium carboxymethyl cellulose is a derivative of natural high molecular weight cellulose obtained by carboxymethylation, which has high liquid absorption capacity and biocompatibility. Therefore, many cellulose products, such as fibers or fabrics, are now widely used in the field of medical dressings after carboxymethylation, such as hemostatic gauze, wound dressing core layer, etc. This type of fiber or fabric has high liquid absorption, which can reach 12-15 times its own weight, equivalent to 4-5 times of 6 layers of gauze. After absorbing / locking the wound exudate, the dressing quickly forms a gel, which can maintain a moist healing environment for the wound and soften the necrotic tissue to achieve the purpose of autologous dissolution and debridement. At the same time, the dressing made of this material absorbs the exudate and forms a gel, which is soft and easy to remove. It will not damage the tendon, wound granulation tissue or healthy tissue around the wound, reducing the pain of patients when changing dressings.

[0003] For fabrics used in the field of medical dressings, their antibacterial properties are crucial. It is one of the important indicators for measuring the performance of medical dressings and greatly affects the healing speed of wounds.

[0004] Currently, the antibacterial treatment of fabrics mostly involves immersing the fabrics in antibacterial solutions. In the weakly alkaline exudate environment of the wound, the antibacterial substances in the antibacterial fabrics prepared in this way are prone to rapid shedding, release and accumulation, which poses potential hazards. Summary of the invention

[0005] In order to solve the problem that the antibacterial substances in the antibacterial fabrics in the prior art are easy to fall off, the present invention provides a method for preparing antibacterial fabrics, which grafts the antibacterial substances onto the fabric through chemical bonds to avoid the antibacterial substances from falling off quickly, thereby solving the problem that the antibacterial substances in the antibacterial fabrics in the prior art are easy to fall off.

[0006] The technical solution adopted by the present invention to solve its technical problem is: A method for preparing an antibacterial fabric comprises the following steps: S1: Carboxymethylating the original fabric to obtain a carboxymethylated fabric; S2: performing cross-linking grafting treatment on the carboxymethylated fabric by using an inclusion agent and a cross-linking agent to obtain a grafted fabric; S3: Immersing the grafted fabric in an antibacterial solution to obtain an antibacterial fabric.

[0007] Optionally, step S2 includes the following steps: S21: dissolving the inclusion agent in deionized water, adding a cross-linking agent and a catalyst to obtain a pretreatment solution; mixing the pretreatment solution with ethanol to obtain a fabric finishing solution; S22: treating the carboxymethylated fabric with the fabric finishing liquid through a two-immersion and two-binding process to obtain a grafted fabric.

[0008] Optionally, the inclusion agent is β-cyclodextrin.

[0009] Optionally, the cross-linking agent is glutaraldehyde.

[0010] Optionally, the catalyst is magnesium chloride hexahydrate.

[0011] Optionally, step S1 includes: S11: immersing the original fabric in a sodium hydroxide aqueous solution, alkalizing it at room temperature, and then performing a dehydration treatment to obtain fabric A; S12: immersing the fabric A in a mixture of sodium chloroacetate and ethanol and water, performing an etherification treatment at 35° C. to 85° C., and then taking out the fabric A for dehydration treatment to obtain fabric B; S13: neutralizing the fabric B in a mixed solution of acetic acid / ethanol / water, and washing the solution until it is neutral to obtain a carboxymethylated fabric.

[0012] Optionally, the antibacterial solution is a biguanide antibacterial agent solution.

[0013] Optionally, the biguanide antibiotic solution is a mixed solution of biguanide antibiotics in ethanol and water.

[0014] Another object of the present invention is to provide an antibacterial fabric, which is prepared by the method for preparing the antibacterial fabric as described above.

[0015] Another object of the present invention is to provide a dressing comprising the antibacterial fabric as described above.

[0016] The beneficial effects of the present invention are: The method for preparing the antibacterial fabric provided by the present invention comprises the following steps: firstly subjecting the original fabric to carboxymethylation treatment, and then subjecting the original fabric to cross-linking grafting treatment, so that the inclusion agent is grafted onto the fabric while improving the strength and flexibility of the fabric; finally, the inclusion agent is impregnated to encapsulate the antibacterial substance to obtain the antibacterial fabric, so that the prepared antibacterial fabric has high liquid absorption, high strength and flexibility, and at the same time, the antibacterial substance in the antibacterial fabric is not easy to fall off quickly, thereby improving the safety and the stability and durability of the antibacterial performance. DETAILED DESCRIPTION

[0017] The present invention is now further described in detail. The embodiments described below are exemplary and intended to be used to explain the present invention, but cannot be understood as limiting the present invention. All other embodiments obtained by ordinary technicians in this field without creative work based on the embodiments of the present invention belong to the scope of protection of the present invention.

[0018] At present, the antibacterial fabrics prepared by the impregnation method have antibacterial substances that are easily oxidized. In the weakly alkaline exudate environment of the wound, the antibacterial substances are easily shed, released and accumulated, which is potentially harmful.

[0019] In order to solve the problem that the antibacterial material of the antibacterial fabric in the prior art is easy to fall off, the present invention provides a method for preparing the antibacterial fabric, which comprises the following steps: S1: Carboxymethylating the original fabric to obtain a carboxymethylated fabric; S2: cross-linking and grafting the carboxymethylated fabric using an inclusion agent and a cross-linking agent to obtain a grafted fabric; S3: The grafted fabric is immersed in an antibacterial solution, preferably immersed at 50°C for 1-2 hours, then rapidly cooled in an ice water bath and allowed to stand overnight, then taken out and repeatedly washed with an ethanol solution and dried to obtain an antibacterial fabric.

[0020] The original fabric may be a fabric made of regenerated cellulose fiber and (or) one of alginate fiber and chitosan fiber or a combination of two of them; the original fabric is treated with carboxymethylation to make it highly absorbent and improve its liquid absorption capacity; however, the physical and chemical structure of the original fabric is changed during the carboxymethylation process, especially the chemical modification uses the hydroxyl groups of the cellulose molecules in the fiber as active reaction sites, and the hydrogen bonding between the hydroxyl groups in the cellulose molecular chain is an important factor in providing the strength of the fiber and the fabric. The hydroxyl groups are destroyed, the hydrogen bonding is weakened, and the strength is reduced, resulting in the prepared carboxymethylated fabric often showing low strength and low flexibility after drying, which is not easy to be processed and applied.

[0021] In order to improve the strength and flexibility of the fabric, the present invention further performs cross-linking grafting treatment on the carboxymethylated fabric. On the basis of the carboxymethylated fabric, the grafting inclusion agent is cross-linked by a cross-linking agent; the carboxymethylated fabric contains a large number of carboxyl groups and hydroxyl groups. Through the cross-linking effect of the cross-linking agent, a ternary interwoven network (cellulose molecular chain-cross-linking agent-inclusion agent in the fabric) can be effectively constructed inside the fabric, that is, the grafted fabric. The ternary cross-linking structure makes the fabric have good strength, and the grafting of the inclusion agent increases the roughness between the fibers, which helps to increase the interweaving force between the fibers and further improve its strength and flexibility.

[0022] In order to give the fabric antibacterial properties, the grafted fabric is immersed in an antibacterial solution. During the immersion process, the inclusion agent grafted on the fabric effectively includes the antibacterial substance in the antibacterial solution to obtain the antibacterial fabric.

[0023] Since the antibacterial fabric in the present invention is encapsulated by an inclusion agent, on the one hand, the antibacterial substance can be prevented from being oxidized, and on the other hand, the release of the antibacterial substance is made more stable, and the rapid shedding and accumulation of the antibacterial substance is prevented, thereby improving safety; and, since the inclusion agent in the present invention is grafted onto the fabric through cross-linking, the inclusion method is more stable and the drug release is also more stable compared to simple immersion adsorption.

[0024] The method for preparing the antibacterial fabric provided by the present invention comprises the following steps: firstly subjecting the original fabric to carboxymethylation treatment, and then subjecting the original fabric to cross-linking grafting treatment, so that the inclusion agent is grafted onto the fabric while improving the strength and flexibility of the fabric; finally, the inclusion agent is impregnated to encapsulate the antibacterial substance to obtain the antibacterial fabric, so that the prepared antibacterial fabric has high liquid absorption, high strength and flexibility, and at the same time, the antibacterial substance in the antibacterial fabric is not easy to fall off quickly, thereby improving the safety and the stability and durability of the antibacterial performance.

[0025] Specifically, the preferred step S2 of the present invention comprises the following steps: S21: dissolving the inclusion agent in deionized water, preferably dissolving it in deionized water at 60° C., adding a crosslinking agent and a catalyst, preferably continuously stirring and keeping warm for 30 minutes to obtain a pretreatment solution; mixing the pretreatment solution with ethanol to obtain a fabric finishing solution; Preferably, the mass ratio of the inclusion agent, deionized water, crosslinking agent and catalyst in this step is (3-7):80:10:3; preferably, the volume ratio of the pretreatment liquid to ethanol is 1:(1-1.5), and more preferably 1:1.5.

[0026] S22: treating the carboxymethylated fabric with a fabric finishing solution through a two-immersion and two-binding process, and then washing with an ethanol / water mixture to obtain a grafted fabric.

[0027] Preferably, in this step, the ratio of the amount of the carboxymethylated fabric to the fabric finishing liquid is 1 g: (15-30) mL; and the volume ratio of ethanol to water in the ethanol / water mixture is (1-1.5): (1).

[0028] In order to achieve both the strength and antibacterial durability of the antibacterial fabric, the preferred inclusion agent of the present invention is β-cyclodextrin.

[0029] The carboxymethylated fabric C contains a large number of carboxyl groups and hydroxyl groups. β-cyclodextrin is also a polyhydroxy substance. Through the cross-linking effect of the cross-linking agent, the ternary interwoven network inside the fabric can be more effectively constructed.

[0030] To ensure the cross-linking grafting effect, the preferred cross-linking agent of the present invention is glutaraldehyde, and the preferred catalyst is magnesium chloride hexahydrate.

[0031] The invention is based on the carboxymethylated fabric, cross-links and grafts beta-cyclodextrin through glutaraldehyde, and at the same time, the inclusion agent is grafted on the fabric, thereby improving the fabric strength and flexibility.

[0032] The process of carboxymethylating the fabric in the present invention, i.e., step S1, comprises: S11: immersing the original fabric in a sodium hydroxide aqueous solution for alkalization treatment at room temperature, preferably for 5 min to 60 min, then taking it out of the solution for dehydration treatment to obtain fabric A; The sodium hydroxide aqueous solution is a concentrated sodium hydroxide aqueous solution with a concentration of 10wt.% to 40wt.%; S12: immersing fabric A in a mixture of sodium chloroacetate, ethanol and water, and subjecting it to etherification treatment at 35° C. to 85° C., preferably at 50° C. to 85° C., preferably after treating it for 5 min to 60 min, taking it out of the mixture and subjecting it to deliquescence treatment, thereby obtaining fabric B; Preferably, the concentration of sodium chloroacetate in the ethanol-water mixture of sodium chloroacetate is 10wt.%~40wt.%, and more preferably 25wt.%~40wt.%, and the volume ratio of ethanol to water is (1~1.5): (1); S13: Fabric B is neutralized in a mixture of acetic acid / ethanol / water, and then repeatedly washed with a mixture of ethanol / water until the washing solution becomes neutral, thereby obtaining fabric C, i.e., a carboxymethylated fabric.

[0033] Preferably, in the acetic acid / ethanol / water mixture of step S13, the volume ratio of acetic acid, ethanol and water is 0.2:(1-2.3):1; and the volume ratio of ethanol and water in the ethanol / water mixture is (1-1.5):1.

[0034] In order to ensure the antibacterial properties of the antibacterial fabric, the present invention preferably uses a biguanide compound as the antibacterial substance, that is, a biguanide antibacterial agent, and the antibacterial solution is a biguanide antibacterial agent solution.

[0035] Biguanide compounds are a type of cationic surfactant preservative with strong broad-spectrum antibacterial and bactericidal abilities. They are commonly used in clinical practice to disinfect instruments, skin, and mucous membranes. In recent years, they have also been used for oral anti-inflammatory, abdominal cavity, and intestinal mucosal disinfection and sterilization during surgery. They can adsorb on the permeability barrier of bacterial cell membranes, change the ion permeability of bacterial cell membranes, and cause cell contents to leak out. Low concentrations can inhibit bacteria, and high concentrations can kill bacteria.

[0036] In the present invention, the biguanide compound is further preferably chlorhexidine acetate.

[0037] The present invention is based on the fact that β-cyclodextrin is a cyclic oligosaccharide composed of multiple glucose molecules, and its structure is similar to a cylindrical ring, with a hydrophobic inner cavity and a hydrophilic outer wall, which can effectively include biguanide antibacterial agents to achieve the antibacterial effect of the fabric. Compared with simple immersion adsorption, the inclusion method is more stable and the drug release is also more stable. At the same time, the carboxymethylation of the fabric enables the fabric to obtain a stronger liquid absorption capacity, so that the antibacterial fabric provided by the present invention has both high absorbency and antibacterial properties.

[0038] The preferred biguanide antibacterial agent solution of the present invention is a mixed solution of biguanide antibacterial agent and ethanol water.

[0039] Specifically, the ethanol-water mixed solution of the preferred biguanide antibacterial agent of the present invention is prepared according to the following method: The biguanide antibiotics are dissolved in ethanol, preferably in a ratio of (1.00-10.00) g to 300 mL of ethanol, to obtain a premixed solution; the premixed solution is then mixed with water at a volume ratio of 1.5:1 to obtain an ethanol-water mixed solution of the biguanide antibiotics.

[0040] The method for preparing the antibacterial fabric provided by the present invention does not require a harsh preparation environment, is simple to operate, and is easy to achieve large-scale production; the fabric prepared by the method has both antibacterial and high absorbency, and has great application prospects in medical dressings.

[0041] During the preparation process, the use of cross-linking agent glutaraldehyde, together with the cellulose molecular skeleton and beta-cyclodextrin in the fabric, forms a ternary interwoven structure, thereby enhancing the roughness of the fibers, improving the interweaving ability of the fibers between the fabrics, and improving the strength phenomenon of the fabric that is reduced due to carboxymethylation, thereby obtaining a fabric with good strength and flexibility; beta-cyclodextrin is chemically grafted onto the fabric and has good stability in the weakly alkaline environment of wound exudate, is not easy to fall off and degrade, and can slowly release the biguanide antibacterial agent contained therein to maintain the antibacterial properties of the fabric.

[0042] The preparation method of the antibacterial fabric provided by the present invention is also applicable to regenerated cellulose filaments or staple fibers. The obtained high-absorption antibacterial filaments or staple fibers are post-processed to form non-woven fabrics, which are then cut, packaged and sterilized and can also be used as medical dressings.

[0043] Another object of the present invention is to provide an antibacterial fabric, which is prepared by the method for preparing the antibacterial fabric as described above.

[0044] The antibacterial fabric provided by the present invention comprises the following steps: firstly, the original fabric is subjected to a carboxymethylation treatment, and then a cross-linking grafting treatment is performed to graft an inclusion agent onto the fabric, thereby improving the strength and flexibility of the fabric; finally, the inclusion agent is impregnated to include the antibacterial substance to obtain the antibacterial fabric, so that the prepared antibacterial fabric has high liquid absorption, high strength and flexibility, and at the same time, the antibacterial substance in the antibacterial fabric is not easy to fall off quickly, thereby improving the safety and the stability and durability of the antibacterial performance.

[0045] The antibacterial fabric provided by the present invention is a high-absorption antibacterial fabric, which has great use value in the field of medical dressings. It has certain strength and flexibility, can be directly combined in medical dressings as a wound contact layer, and can even be used directly.

[0046] It has good liquid absorption capacity and can absorb exudate when used on wounds, avoiding the risk of wound maceration and maintaining a moist healing environment for the wound. In addition, the weakly alkaline wound environment is prone to the growth of antibacterial agents, while β-cyclodextrin has good stability in an alkaline environment and is not easy to fall off or degrade from the fabric. The biguanide antibacterial agent encapsulated in the inner cavity can be continuously and slowly released to the dressing or near the wound, thereby achieving a low-bacteria environment for the entire wound and the surrounding skin environment. "Moist sterile or low-bacteria" conditions are necessary conditions for accelerated wound healing.

[0047] Another object of the present invention is to provide a dressing comprising the antibacterial fabric as described above.

[0048] The dressing provided by the present invention can use antibacterial fabric as a base material, or directly use antibacterial fabric as a dressing; in the preparation process of the antibacterial fabric, the original fabric is firstly subjected to carboxymethylation treatment, and then subjected to cross-linking and grafting treatment, so that the inclusion agent is grafted onto the fabric while improving the strength and flexibility of the fabric; finally, the inclusion agent is impregnated to encapsulate the antibacterial substance to obtain the antibacterial fabric, so that the prepared antibacterial fabric has high liquid absorption, high strength and flexibility, and at the same time, the antibacterial substance in the antibacterial fabric is not easy to fall off quickly, thereby improving the safety while improving the stability and durability of the antibacterial performance.

[0049] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, specific embodiments of the present invention are described in detail below.

[0050] Example 1 This embodiment provides a method for preparing an antibacterial fabric, comprising the following steps: S11: immersing the Tencel fabric in a sodium hydroxide aqueous solution with a concentration of 25 wt.%, alkalizing the fabric at room temperature for 30 minutes, and then taking the fabric out of the solution for dehydration treatment to obtain fabric A; S12: immersing fabric A in a mixture of sodium chloroacetate, ethanol and water, and etherifying the mixture at 60° C. for 45 min, then taking the fabric A out of the mixture for de-liquidation treatment to obtain fabric B; The concentration of sodium chloroacetate in the ethanol-water mixture of sodium chloroacetate is 25wt.%, and the volume ratio of ethanol to water is 1.2:1; S13: After neutralizing fabric B in a mixture of acetic acid / ethanol / water, the fabric is repeatedly washed with a mixture of ethanol / water until the washing solution becomes neutral, thereby obtaining fabric C, i.e., a carboxymethylated fabric; The volume ratio of acetic acid, ethanol and water in the acetic acid / ethanol / water mixture is 0.2:1.5:1; the volume ratio of ethanol and water in the ethanol / water mixture is 1.2:1; S21: dissolving β-cyclodextrin in deionized water at 60° C., adding glutaraldehyde and magnesium chloride hexahydrate, stirring continuously and keeping warm for 30 minutes to obtain a pretreatment solution; mixing the pretreatment solution with ethanol at a volume ratio of 1:1.2 to obtain a fabric finishing solution; In this step, the mass ratio of β-cyclodextrin, deionized water, glutaraldehyde and magnesium chloride hexahydrate is 5:80:10:3; S22: treating the carboxymethylated fabric with a fabric finishing solution through a two-immersion and two-binding process, and then washing with an ethanol / water mixture to obtain a grafted fabric; The ratio of carboxymethylated fabric to fabric finishing liquid was 1 g:20 mL; the volume ratio of ethanol to water in the ethanol / water mixture was 1.2:1; S3: Take biguanide antibacterial agent chlorhexidine acetate and dissolve it in ethanol, wherein the ratio of biguanide antibacterial agent to ethanol is 5.00g:300mL, to obtain a premixed solution; then mix the premixed solution with water at a volume ratio of 1.5:1 to obtain an ethanol-water mixed solution of the biguanide antibacterial agent; place the grafted fabric in the ethanol-water mixed solution of the biguanide antibacterial agent, immerse it at 50°C for 1.5h, then quickly cool it in an ice water bath and let it stand overnight, then take it out and repeatedly wash it with ethanol solution, dry it, and obtain the antibacterial fabric.

[0051] Example 2 This embodiment provides a method for preparing an antibacterial fabric, comprising the following steps: S11: immersing the Tencel fabric in a sodium hydroxide aqueous solution with a concentration of 25 wt.%, alkalizing the fabric at room temperature for 60 min, and then taking the fabric out of the solution for dehydration treatment to obtain fabric A; S12: immersing fabric A in a mixture of sodium chloroacetate, ethanol and water, and etherifying the mixture at 50° C. for 60 min, then taking the fabric A out of the mixture and performing a de-liquidation treatment to obtain fabric B; The concentration of sodium chloroacetate in the ethanol-water mixture of sodium chloroacetate is 25wt.%, and the volume ratio of ethanol to water is 1.5:1; S13: After neutralizing fabric B in a mixture of acetic acid / ethanol / water, the fabric is repeatedly washed with a mixture of ethanol / water until the washing solution becomes neutral, thereby obtaining fabric C, i.e., a carboxymethylated fabric; The volume ratio of acetic acid, ethanol and water in the acetic acid / ethanol / water mixture is 0.2:1:1; the volume ratio of ethanol and water in the ethanol / water mixture is 1.5:1; S21: dissolving β-cyclodextrin in deionized water at 60° C., adding glutaraldehyde and magnesium chloride hexahydrate, stirring continuously and keeping warm for 30 minutes to obtain a pretreatment solution; mixing the pretreatment solution with ethanol at a volume ratio of 1:1.5 to obtain a fabric finishing solution; In this step, the mass ratio of β-cyclodextrin, deionized water, glutaraldehyde and magnesium chloride hexahydrate is 7:80:10:3; S22: treating the carboxymethylated fabric with a fabric finishing solution through a two-immersion and two-binding process, and then washing with an ethanol / water mixture to obtain a grafted fabric; The ratio of carboxymethylated fabric to fabric finishing liquid is 1 g:15 mL; the volume ratio of ethanol to water in the ethanol / water mixture is 1.5:1; S3: Take biguanide antibacterial agent chlorhexidine acetate and dissolve it in ethanol, wherein the dosage ratio of biguanide antibacterial agent to ethanol is 1.00g:300mL, to obtain a premixed solution; then mix the premixed solution with water at a volume ratio of 1.5:1 to obtain an ethanol-water mixed solution of the biguanide antibacterial agent; place the grafted fabric in the ethanol-water mixed solution of the biguanide antibacterial agent, immerse it at 50°C for 1.5h, then quickly cool it in an ice water bath and let it stand overnight, then take it out and repeatedly wash it with ethanol solution, dry it, and obtain the antibacterial fabric.

[0052] Example 3 This embodiment provides a method for preparing an antibacterial fabric, comprising the following steps: S11: immersing the Tencel fabric in a 40 wt.% sodium hydroxide aqueous solution, alkalizing it at room temperature for 30 minutes, and then taking it out of the solution for dehydration treatment to obtain fabric A; S12: immersing fabric A in a mixture of sodium chloroacetate and ethanol and water, subjecting it to etherification treatment at 60° C. for 60 min, and then taking it out of the mixture for dehydration treatment to obtain fabric B; The concentration of sodium chloroacetate in the ethanol-water mixture of sodium chloroacetate is 40wt.%, and the volume ratio of ethanol to water is 1:1; S13: After neutralizing fabric B in a mixture of acetic acid / ethanol / water, the fabric is repeatedly washed with a mixture of ethanol / water until the washing solution becomes neutral, thereby obtaining fabric C, i.e., a carboxymethylated fabric; The volume ratio of acetic acid, ethanol and water in the acetic acid / ethanol / water mixture is 0.2:2.3:1; the volume ratio of ethanol and water in the ethanol / water mixture is 1:1; S21: dissolving β-cyclodextrin in deionized water at 60° C., adding glutaraldehyde and magnesium chloride hexahydrate, stirring continuously and keeping warm for 30 minutes to obtain a pretreatment solution; mixing the pretreatment solution with ethanol in a volume ratio of 1:1 to obtain a fabric finishing solution; In this step, the mass ratio of β-cyclodextrin, deionized water, glutaraldehyde and magnesium chloride hexahydrate is 3:80:10:3; S22: treating the carboxymethylated fabric with a fabric finishing solution through a two-immersion and two-binding process, and then washing with an ethanol / water mixture to obtain a grafted fabric; The ratio of carboxymethylated fabric to fabric finishing liquid is 1 g:30 mL; the volume ratio of ethanol to water in the ethanol / water mixture is 1:1; S3: Take biguanide antibacterial agent chlorhexidine acetate and dissolve it in ethanol, wherein the ratio of biguanide antibacterial agent to ethanol is 5.00g:300mL, to obtain a premixed solution; then mix the premixed solution with water at a volume ratio of 1.5:1 to obtain an ethanol-water mixed solution of the biguanide antibacterial agent; place the grafted fabric in the ethanol-water mixed solution of the biguanide antibacterial agent, immerse it at 50°C for 1.5h, then quickly cool it in an ice water bath and let it stand overnight, then take it out and repeatedly wash it with ethanol solution, dry it, and obtain the antibacterial fabric.

[0053] Comparative Example 1 This comparative example provides a method for preparing a fabric, comprising the following steps: S11: immersing the Tencel fabric in a sodium hydroxide aqueous solution with a concentration of 25 wt.%, alkalizing the fabric at room temperature for 30 minutes, and then taking the fabric out of the solution for dehydration treatment to obtain fabric A; S12: immersing fabric A in a mixture of sodium chloroacetate, ethanol and water, and etherifying the mixture at 60° C. for 45 min, then taking the fabric A out of the mixture for de-liquidation treatment to obtain fabric B; The concentration of sodium chloroacetate in the ethanol-water mixture of sodium chloroacetate is 25wt.%, and the volume ratio of ethanol to water is 1.2:1; S13: After neutralizing fabric B in a mixture of acetic acid / ethanol / water, the fabric is repeatedly washed with a mixture of ethanol / water until the washing solution becomes neutral, thereby obtaining fabric C, i.e., a carboxymethylated fabric; The volume ratio of acetic acid, ethanol and water in the acetic acid / ethanol / water mixture is 0.2:1.5:1; the volume ratio of ethanol and water in the ethanol / water mixture is 1.2:1; S21: dissolving β-cyclodextrin in deionized water at 60° C., adding glutaraldehyde and magnesium chloride hexahydrate, stirring continuously and keeping warm for 30 minutes to obtain a pretreatment solution; mixing the pretreatment solution with ethanol at a volume ratio of 1:1.2 to obtain a fabric finishing solution; In this step, the mass ratio of β-cyclodextrin, deionized water, glutaraldehyde and magnesium chloride hexahydrate is 5:80:10:3; S22: treating the carboxymethylated fabric with a fabric finishing liquid through a two-immersion and two-binding process, and washing it with an ethanol / water mixture to obtain a grafted fabric; and drying to obtain a target fabric.

[0054] The dosage ratio of the carboxymethylated fabric to the fabric finishing liquid is 1 g:20 mL; the volume ratio of ethanol to water in the ethanol / water mixture is 1.2:1.

[0055] Comparative Example 2 This comparative example provides a method for preparing a fabric, comprising the following steps: S21: dissolving β-cyclodextrin in deionized water at 60° C., adding glutaraldehyde and magnesium chloride hexahydrate, stirring continuously and keeping warm for 30 minutes to obtain a pretreatment solution; mixing the pretreatment solution with ethanol at a volume ratio of 1:1.2 to obtain a fabric finishing solution; In this step, the mass ratio of β-cyclodextrin, deionized water, glutaraldehyde and magnesium chloride hexahydrate is 5:80:10:3; S22: treating the untreated Tencel fabric with a fabric finishing liquid through a two-immersion and two-binding process, and washing with an ethanol / water mixture to obtain a grafted fabric; The dosage ratio of the untreated Tencel fabric to the fabric finishing liquid was 1 g: 20 mL; the volume ratio of ethanol to water in the ethanol / water mixture was 1.2: 1; S3: Take biguanide antibacterial agent chlorhexidine acetate and dissolve it in ethanol, wherein the ratio of biguanide antibacterial agent to ethanol is 5.00g:300mL, to obtain a premixed solution; then mix the premixed solution with water at a volume ratio of 1.2:1 to obtain an ethanol-water mixed solution of the biguanide antibacterial agent; place the grafted fabric in the ethanol-water mixed solution of the biguanide antibacterial agent, immerse it at 50°C for 1.5h, then quickly cool it in an ice water bath and let it stand overnight, then take it out and repeatedly wash it with ethanol solution, dry it, and obtain the antibacterial fabric.

[0056] Comparative Example 3 This comparative example provides a method for preparing an antibacterial fabric, comprising the following steps: S11: immersing the Tencel fabric in a sodium hydroxide aqueous solution with a concentration of 25 wt.%, alkalizing the fabric at room temperature for 30 minutes, and then taking the fabric out of the solution for dehydration treatment to obtain fabric A; S12: immersing fabric A in a mixture of sodium chloroacetate, ethanol and water, and etherifying the mixture at 60° C. for 45 min, then taking the fabric A out of the mixture for de-liquidation treatment to obtain fabric B; The concentration of sodium chloroacetate in the ethanol-water mixture of sodium chloroacetate is 25wt.%, and the volume ratio of ethanol to water is 1.2:1; S13: After neutralizing fabric B in a mixture of acetic acid / ethanol / water, the fabric is repeatedly washed with a mixture of ethanol / water until the washing solution becomes neutral, thereby obtaining fabric C, i.e., a carboxymethylated fabric; The volume ratio of acetic acid, ethanol and water in the acetic acid / ethanol / water mixture is 0.2:1.5:1; the volume ratio of ethanol and water in the ethanol / water mixture is 1.2:1; S21: Add glutaraldehyde and magnesium chloride hexahydrate to deionized water at 60° C., continue stirring and keep warm for 30 minutes to obtain a pretreatment solution; mix the pretreatment solution with ethanol in a volume ratio of 1:1.2 to obtain a fabric finishing solution; In this step, the mass ratio of deionized water, glutaraldehyde and magnesium chloride hexahydrate is 80:10:3; S22: treating the carboxymethylated fabric with a fabric finishing solution through a two-immersion and two-binding process, and then washing with an ethanol / water mixture to obtain a cross-linked fabric; The ratio of carboxymethylated fabric to fabric finishing liquid was 1 g:20 mL; the volume ratio of ethanol to water in the ethanol / water mixture was 1.2:1; S3: Take the biguanide antibacterial agent chlorhexidine acetate and dissolve it in ethanol, wherein the amount ratio of the biguanide antibacterial agent to ethanol is 5.00g:300mL, to obtain a premixed solution; then mix the premixed solution with water at a volume ratio of 1.5:1 to obtain an ethanol-water mixed solution of the biguanide antibacterial agent; place the cross-linked fabric in the ethanol-water mixed solution of the biguanide antibacterial agent, immerse it at 50°C for 1.5h, then quickly cool it in an ice water bath and let it stand overnight, then take it out and repeatedly wash it with an ethanol solution, and dry it to obtain an antibacterial fabric.

[0057] Comparative Example 4 This comparative example provides a method for preparing an antibacterial fabric, comprising the following steps: S11: immersing the Tencel fabric in a sodium hydroxide aqueous solution with a concentration of 25 wt.%, alkalizing the fabric at room temperature for 30 minutes, and then taking the fabric out of the solution for dehydration treatment to obtain fabric A; S12: immersing fabric A in a mixture of sodium chloroacetate, ethanol and water, and etherifying the mixture at 60° C. for 45 min, then taking the fabric A out of the mixture for de-liquidation treatment to obtain fabric B; The concentration of sodium chloroacetate in the ethanol-water mixture of sodium chloroacetate is 25wt.%, and the volume ratio of ethanol to water is 1.2:1; S13: After neutralizing fabric B in a mixture of acetic acid / ethanol / water, the fabric is repeatedly washed with a mixture of ethanol / water until the washing solution becomes neutral, thereby obtaining fabric C, i.e., a carboxymethylated fabric; The volume ratio of acetic acid, ethanol and water in the acetic acid / ethanol / water mixture is 0.2:1.5:1; the volume ratio of ethanol and water in the ethanol / water mixture is 1.2:1; S21: dissolving β-cyclodextrin in deionized water at 60° C., adding magnesium chloride hexahydrate, stirring continuously and keeping warm for 30 minutes to obtain a pretreatment solution; mixing the pretreatment solution with ethanol at a volume ratio of 1:1.2 to obtain a fabric finishing solution; In this step, the mass ratio of β-cyclodextrin, deionized water and magnesium chloride hexahydrate is 5:80:3; S22: treating the carboxymethylated fabric with a fabric finishing solution through a two-immersion and two-binding process, and then washing with an ethanol / water mixture to obtain a grafted fabric; The ratio of carboxymethylated fabric to fabric finishing liquid was 1 g:20 mL; the volume ratio of ethanol to water in the ethanol / water mixture was 1.2:1; S3: Take biguanide antibacterial agent chlorhexidine acetate and dissolve it in ethanol, wherein the ratio of biguanide antibacterial agent to ethanol is 5.00g:300mL, to obtain a premixed solution; then mix the premixed solution with water at a volume ratio of 1.5:1 to obtain an ethanol-water mixed solution of the biguanide antibacterial agent; place the grafted fabric in the ethanol-water mixed solution of the biguanide antibacterial agent, immerse it at 50°C for 1.5h, then quickly cool it in an ice water bath and let it stand overnight, then take it out and repeatedly wash it with ethanol solution, dry it, and obtain the antibacterial fabric.

[0058] The original fabric, the materials in the embodiments and the comparative examples were respectively subjected to a liquid absorbency test according to the method in YY / T 0471.1-2004; the fabric strength test was conducted according to the method in GB / T 3923.1-1997; and the antibacterial test was conducted according to the method in GB / T20944.3-2008. The test results are shown in Tables 1 and 2.

[0059] Table 1 Liquid Absorption Tensile Strength Original fabric 4.71g / g 13.41 N / cm Example 1 12.65g / g 3.97N / cm Example 2 11.91g / g 3.66N / cm Example 3 13.66 g / g 4.12N / cm Comparative Example 1 14.22g / g 3.85N / cm Comparative Example 2 4.78g / g 9.26N / cm Comparative Example 3 14.62g / g 7.71N / cm Comparative Example 4 5.03 g / g 3.68N / cm Table 2 Average concentration of live Staphylococcus aureus (CFU / mL) Antibacterial rate against Staphylococcus aureus Average concentration of live Escherichia coli (CFU / mL) Antibacterial rate against Escherichia coli Original fabric 2.1×107 0 3.4×107 0 Example 1 3.3×103 99.8% ＜1000 ＞99.92% Example 2 4.2×103 99.8% ＜1000 ＞99.92% Example 3 ＜1000 ＞99.96% ＜1000 ＞99.92% Comparative Example 1 2.8×107 0 4.0×107 0 Comparative Example 2 1.0×104 99.6% ＜1000 ＞99.92% Comparative Example 3 2.1×106 16.0% 1.3×106 7.1% Comparative Example 4 2.3×106 8.0% 1.2×106 14.3% It can be seen from the data in the above table that the antibacterial fabric provided by the present invention has high liquid absorbency and good antibacterial ability.

[0060] The difference between Comparative Example 1 and Example 1 is that the inclusion step of the biguanide antibacterial agent is not performed; although the fabric prepared in this comparative example has high liquid absorbency, it has no antibacterial ability.

[0061] The difference between Comparative Example 2 and Example 1 is that the original fabric is not subjected to carboxymethylation treatment; the fabric prepared in this comparative example has good antibacterial ability, but poor liquid absorption.

[0062] The difference between Comparative Example 3 and Example 1 is that β-cyclodextrin is not grafted onto the fabric; the fabric prepared in this comparative example has good liquid absorbency, but poor antibacterial ability.

[0063] The difference between Comparative Example 4 and Example 1 is that no cross-linking treatment is performed on the fabric by using a cross-linking agent; the fabric prepared in this comparative example has good liquid absorbency, but poor antibacterial ability.

[0064] Based on the above ideal embodiments of the present invention, the relevant staff can make various changes and modifications without departing from the technical concept of the present invention through the above description. The technical scope of the present invention is not limited to the contents of the specification, and its technical scope must be determined according to the scope of the claims.

Claims

1. A method for preparing an antibacterial fabric, characterized in that: The steps include: S1: Carboxymethylating the original fabric to obtain a carboxymethylated fabric; S2: performing cross-linking grafting treatment on the carboxymethylated fabric by using an inclusion agent and a cross-linking agent to obtain a grafted fabric; S3: Immersing the grafted fabric in an antibacterial solution to obtain an antibacterial fabric.

2. The method for preparing the antibacterial fabric according to claim 1, characterized in that: Step S2 includes the following steps: S21: dissolving the inclusion agent in deionized water, adding a cross-linking agent and a catalyst to obtain a pretreatment solution; mixing the pretreatment solution with ethanol to obtain a fabric finishing solution; S22: treating the carboxymethylated fabric with the fabric finishing liquid through a two-immersion and two-binding process to obtain a grafted fabric.

3. The method for preparing the antibacterial fabric according to claim 2, characterized in that: The inclusion agent is β-cyclodextrin.

4. The method for preparing the antibacterial fabric according to claim 2, characterized in that: The cross-linking agent is glutaraldehyde.

5. The method for preparing the antibacterial fabric according to claim 2, characterized in that: The catalyst is magnesium chloride hexahydrate.

6. The method for preparing the antibacterial fabric according to any one of claims 1 to 5, characterized in that: Step S1 includes: S11: immersing the original fabric in a sodium hydroxide aqueous solution, alkalizing it at room temperature, and then performing a dehydration treatment to obtain fabric A; S12: immersing the fabric A in a mixture of sodium chloroacetate and ethanol and water, performing an etherification treatment at 35° C. to 85° C., and then taking out the fabric A for dehydration treatment to obtain fabric B; S13: neutralizing the fabric B in a mixed solution of acetic acid / ethanol / water, and washing the solution until it is neutral to obtain a carboxymethylated fabric.

7. The method for preparing the antibacterial fabric according to any one of claims 1 to 5, characterized in that: The antibacterial solution is a biguanide antibacterial agent solution.

8. The method for preparing the antibacterial fabric according to claim 7, characterized in that: The biguanide antibiotic solution is a mixed solution of biguanide antibiotics in ethanol and water.

9. An antibacterial fabric, characterized in that: The antibacterial fabric is prepared by the method for preparing the antibacterial fabric according to any one of claims 1 to 8.

10. A dressing, characterized in that: Comprising the antibacterial fabric as claimed in claim 9.