Residue-free tooth whitening strip and preparation method thereof

Abstract

The invention discloses a residue-free tooth whitening patch and a preparation method thereof, and relates to the technical field of oral care, and the tooth whitening patch comprises a soft film layer, a bottom lining layer and a gel layer located between the soft film layer and the bottom lining layer, the gel layer is prepared from the following components in parts by weight: 0.5 to 15.0 parts of a permeable acrylate copolymer film forming agent, 2.0 to 35.0 parts of a tackifier, 0.1 to 15.0 parts of a thickening agent, 10.0 to 50.0 parts of medical alcohol, 10.0 to 50.0 parts of purified water, 0.5 to 15.0 parts of a humectant, 0.1 to 15.0 parts of a whitening agent, 0.01 to 2.0 parts of a pH (Potential of Hydrogen) regulator, 0.01 to 0.30 part of a sweetening agent, 0.01 to 0.40 part of a taste regulator, 0.01 to 5.0 parts of a desensitizer, 0.001 to 0.10 part of a stabilizer and 0.05 to 1.50 parts of a flavoring agent. The permeable polyacrylate copolymer film-forming agent provided by the invention not only can improve the tensile strength and elongation at break of the tooth strip, but also can provide uniform release pore channels of the whitening agent, so that the tooth strip has excellent easy-to-tear no-residue performance and continuous whitening performance.

Description

Technical Field

[0001] The present application relates to the field of oral care technology, and in particular to a residue-free whitening tooth paste and a preparation method thereof. Background Art

[0002] With the improvement of living standards, people pay more and more attention to the beauty of teeth, and the demand for teeth whitening is increasing day by day. At present, there are a wide variety of teeth whitening products on the market, including whitening teeth pens, whitening teeth kits, whitening teeth trays, whitening teeth stickers, etc., which can achieve significant whitening of teeth without damaging teeth during use, and are very popular among consumers. In particular, whitening teeth stickers are not only effective in whitening, but also easy to carry, low in price, simple and practical, and are most favored by consumers.

[0003] Whitening tooth strips are elastic gel-type film patches used for tooth volume enlargement and whitening. They are composed of a film layer, an elastic gel layer, and a backing layer. When in use, peel off the backing layer and stick the elastic gel layer on the tooth surface. The whitening agent contained in the gel layer achieves tooth whitening through physical stain removal or chemical oxidation.

[0004] In order to adapt to the different shapes of tooth surfaces, the gel layer of whitening tooth strips must have sufficient flexibility and plasticity. Therefore, most whitening tooth strips on the market usually use flexible film-forming agents, such as polyvinyl alcohol, cellulose and polyvinyl pyrrolidone. Although flexible film-forming agents are beneficial to tooth whitening, they are prone to breakage when the tooth strips are removed after whitening due to their low intrinsic film strength and poor stability, resulting in the gel layer remaining on the tooth surface, which is commonly known as the "sticky teeth" phenomenon in the field. This not only affects the user experience, but also poses a safety hazard. Summary of the invention

[0005] In order to solve the technical problem that existing whitening tooth pastes are prone to remain on the tooth surface, the present application provides a residue-free whitening tooth paste and a preparation method thereof.

[0006] In order to achieve the above purpose, the technical solution of the embodiment of the present application is:

[0007] The first aspect of the present application provides a residue-free whitening tooth paste, wherein the residue-free whitening tooth paste comprises the following components in parts by weight:

[0008] Provided are 0.5-15.0 parts of a permeable acrylic copolymer film-forming agent, 2.0-35.0 parts of a tackifier, 0.1-15.0 parts of a thickener, 10.0-50.0 parts of medical alcohol, 10.0-50.0 parts of purified water, 0.5-15.0 parts of a moisturizer, 0.1-15.0 parts of a whitening agent, 0.01-2.0 parts of a pH regulator, 0.01-0.30 parts of a sweetener, 0.01-0.40 parts of a taste regulator, 0.01-5.0 parts of a desensitizer, 0.001-0.10 parts of a stabilizer, and 0.05-1.50 parts of a flavoring agent.

[0009] In combination with the first aspect, preferably, the penetrating acrylate copolymer film-forming agent is prepared by the following method:

[0010] 500.0 mol parts of purified water, 5.0 mol parts of trimethylaminoethyl methacrylate chloride, 0.25 mol parts of OP-10, 0.12 mol parts of hexadecyltrimethylammonium bromide and 0.12 mol parts of isooctyl thioglycolate were added to a dried glass reactor in sequence, and mechanical stirring was performed at room temperature for 0.50 hours. The glass reactor was heated to 65-70° C. at a heating rate of 10° C. per minute, and 0.050 mol parts of ammonium persulfate were added. The reaction was stirred mechanically at a constant temperature of 65-70° C. for 1.0 hour. Then, 15.50 mol parts of methyl methacrylate, 5.50 mol parts of lauryl acrylate, 3.0 mol parts of dimethylaminoethyl methacrylate, 3.0 mol parts of ethylhexyl methacrylate were added dropwise to the glass reactor. A mixed solution consisting of ethyl acetoacetate methyl acrylate and 9.20 mole parts of 2-hydroxypropyl methacrylate is dripped in 1.0 hour, then 0.05 mole parts of ammonium persulfate is added, and the mixture is stirred mechanically at a constant temperature of 65-70° C. for 1.0 hour, then 0.02 mole parts of ammonium persulfate is added, the glass reactor is heated to 80-85° C. at a heating rate of 10° C. per minute, and the mixture is stirred mechanically at a constant temperature of 80-85° C. for 3.0 hours, then cooled to room temperature, filtered with a 200-mesh nylon cloth, discharged, and the filtrate is washed with 300.0 mole parts of purified water for 3 times, and then the filtrate is vacuum dried at 60° C. for 48.0 hours to obtain the permeable polyacrylate copolymer film-forming agent.

[0011] In combination with the first aspect, preferably, the viscosity enhancer is one of polyvinyl pyrrolidone and polyvinyl alcohol.

[0012] In combination with the first aspect, preferably, the thickener is one of sodium cellulose, hydroxyethyl cellulose or hydroxypropyl methyl cellulose.

[0013] In combination with the first aspect, preferably, the purity of the medicinal alcohol is 75%.

[0014] In combination with the first aspect, preferably, the conductivity of the purified water is lower than 1 μS / cm.

[0015] In combination with the first aspect, preferably, the moisturizing agent is one of glycerol, propylene glycol or sorbitol.

[0016] In combination with the first aspect, preferably, the whitening agent is one of carbamide peroxide, phthalimide peroxycaproic acid, hydrogen peroxide, sodium phytate or sodium hypochlorite.

[0017] In combination with the first aspect, preferably, the pH adjuster is one of sodium hydroxide, sodium tripolyphosphate, triethanolamine or potassium dihydrogen phosphate.

[0018] In combination with the first aspect, preferably, the sweetener is one of sucralose, saccharin sodium or steviol glycoside.

[0019] In combination with the first aspect, preferably, the taste regulator is one of citric acid, sodium citrate, potassium citrate or malic acid.

[0020] In combination with the first aspect, preferably, the desensitizing agent is one of potassium nitrate, strontium citrate or hydroxyapatite.

[0021] In combination with the first aspect, preferably, the stabilizer is one of ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetate or tartaric acid.

[0022] In combination with the first aspect, preferably, the flavoring agent is one of menthol, mint flavor, daily chemical flavor, floral flavor or fruity flavor.

[0023] The second aspect of the present application provides a method for preparing the residue-free whitening tooth paste according to the first aspect, the preparation method comprising:

[0024] The permeable polyacrylate copolymer film-forming agent of claim 2, a tackifier, a thickener, medical alcohol, purified water, a moisturizer, a whitening agent, a pH adjuster, a sweetener, a taste adjuster, a desensitizer, a stabilizer and a flavoring agent are mixed and then subjected to vacuum homogenization and emulsification treatment to obtain a gel;

[0025] The gel is coated on the PET film substrate by coating, the adhesive is placed in a drying device for drying, and then the PE soft film is covered on the surface of the gel by embossing to obtain the residue-free whitening tooth paste.

[0026] Compared with the prior art, the advantages or beneficial effects of the embodiments of the present application include at least:

[0027] The permeable polyacrylate copolymer film-forming agent provided in the present application can not only

[0028] It improves the tensile strength and elongation at break of the tooth paste, and can provide channels for uniform release of the whitening agent, so that the tooth paste has excellent easy-to-tear, residue-free performance and continuous whitening performance. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] The drawings constituting part of the present application are used to provide a further understanding of the present application. The exemplary embodiments and descriptions of the present application are used to explain the present application and do not constitute an improper limitation on the present application. Among them:

[0030] Figure 1 It is the structural formula of the permeable polyacrylate copolymer film-forming agent provided in the present application. DETAILED DESCRIPTION

[0031] In order to make the purpose, technical solutions and advantages of the present application clearer, the present application will be further described in detail below in conjunction with the accompanying drawings. The described embodiments should not be regarded as limiting the present application. All other embodiments obtained by ordinary technicians in the field without making creative work are within the scope of protection of this application.

[0032] In the following description, reference is made to "some embodiments", which describe a subset of all possible embodiments, but it is understood that "some embodiments" may be the same subset or different subsets of all possible embodiments, and may be combined with each other without conflict. Unless otherwise defined, all technical and scientific terms used in the embodiments of the present application have the same meaning as those commonly understood by those skilled in the art of the technical field of the embodiments of the present application. The terms used in the embodiments of the present application are only for the purpose of describing the embodiments of the present application and are not intended to limit the present application.

[0033] In the following description of this embodiment, the terms "include", "comprising", "having" and "containing" are all open terms, meaning including but not limited to.

[0034] It should be noted that all raw materials / reagents in the examples of this application can be purchased on the market.

[0035] Purchase or prepare according to conventional methods well known to those skilled in the art; the term "and / or" in the embodiments of the present application is only used to describe the association relationship of associated objects, indicating that there may be three relationships, for example, A and / or B means that A exists alone, B exists alone, and A and B exist at the same time, wherein A and B can be singular or plural, and the character " / " generally indicates that the associated objects before and after are in an "or" relationship.

[0036] In the following description of this embodiment, the term "at least one" refers to one or more, and "plurality" refers to two or more. "At least one of the following" or similar expressions refers to any combination of these items, including any combination of single items or plural items. For example, "at least one of a, b or c", or "at least one of a, b and c", can all represent: a, b, c, ab (i.e., a and b), ac, bc, or abc, where a, b, c can be single or multiple, respectively.

[0037] Those skilled in the art should understand that in the following description of the embodiments of the present application, the order of serial numbers does not mean the order of execution, some or all of the steps can be executed in parallel or sequentially, and the execution order of each process should be determined by its function and internal logic, and should not constitute any limitation on the implementation process of the embodiments of the present application.

[0038] The terms used in the embodiments of the present application are only for the purpose of describing specific embodiments, and are not intended to limit the present application. The singular forms "a", "an" and "the" used in the embodiments of the present application and the appended claims are also intended to include plural forms, unless the context clearly indicates other meanings.

[0039] It should be understood by those skilled in the art that the numerical ranges in the examples of the present application should be understood to also specifically disclose each intermediate value between the upper and lower limits of the range.

[0040] Each smaller range between and intervening values ​​in a stated range and any other stated value or intervening value in that stated range is encompassed within the application. The upper and lower limits of these smaller ranges may independently be included or excluded in the range.

[0041] Unless otherwise stated, the technical / scientific terms used herein have the same meanings as those generally understood by those skilled in the art in the field described in the present application. Although the present application only describes preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the embodiments or test cases of the present application. All documents mentioned in this specification are generally incorporated by reference to disclose and describe the methods and / or materials related to the documents. In the event of a conflict with any incorporated document, the content of the present application shall prevail.

[0042] In a first aspect, the present invention provides a residue-free whitening tooth paste, which comprises the following components in parts by weight:

[0043] Provided are 0.5-15 parts of a permeable acrylic copolymer film-forming agent, 2-35 parts of a tackifier, 0.1-15 parts of a thickener, 10-50 parts of medical alcohol, 10-50 parts of purified water, 0.5-15 parts of a moisturizer, 0.1-15 parts of a whitening agent, 0.01-2 parts of a pH regulator, 0.01-0.3 parts of a sweetener, 0.01-0.4 parts of a taste regulator, 0.01-5 parts of a desensitizer, 0.001-0.1 parts of a stabilizer, and 0.05-1.5 parts of a flavoring agent.

[0044] The permeable polyacrylate copolymer film-forming agent provided in the present application can not only improve the tensile strength and elongation at break of the tooth paste, but also provide pores for uniform release of the whitening agent, thereby making the tooth paste have excellent easy-tear, residue-free performance and continuous whitening performance.

[0045] In a specific embodiment, the permeable polyacrylate copolymer film-forming agent in the embodiment of the present application is prepared by the following method:

[0046] 500.0 mol parts of purified water, 5.0 mol parts of trimethylaminoethyl methacrylate chloride, 0.25 mol parts of OP-10, 0.12 mol parts of hexadecyltrimethylammonium bromide and 0.12 mol parts of isooctyl thioglycolate were added to a dry glass reactor in sequence, and mechanically stirred at room temperature for 0.50 hours. The glass reactor was heated to 65-70° C. at a heating rate of 10° C. per minute, and 0.050 mol parts of ammonium persulfate were added. The reaction mixture was stirred mechanically at a constant temperature of 65-70° C.

[0047] 1.0 hour, then add a mixed solution consisting of 15.50 mol parts of methyl methacrylate, 5.50 mol parts of lauryl acrylate, 3.0 mol parts of dimethylaminoethyl methacrylate, 3.0 mol parts of ethyl acetoacetate methacrylate and 9.20 mol parts of 2-hydroxypropyl methacrylate into the glass reactor, and the dripping is completed within 1.0 hour, then add 0.05 mol parts of ammonium persulfate, keep the temperature at 65-70°C and mechanically stir to react for 1.0 hour, then add 0.02 mol parts of ammonium persulfate, heat the glass reactor to 80-85°C at a heating rate of 10°C per minute, keep the temperature at 80-85°C and mechanically stir to react for 3.0 hours, cool to room temperature, filter with 200-mesh nylon cloth, discharge, wash the filtrate with 300.0 mol parts of purified water 3 times, and then vacuum dry the filtrate at 60°C for 48.0 hours to obtain the permeable polyacrylate copolymer film-forming agent.

[0048] It should be noted that the structural formula of the permeable polyacrylate copolymer film-forming agent is as shown in the accompanying drawing.

[0049] In a specific embodiment, the viscosity enhancer in the embodiment of the present application is one of polyvinyl pyrrolidone and polyvinyl alcohol.

[0050] It should be noted that the tackifier plays a reinforcing role, so that the gel layer of the whitening tooth strip has better mechanical properties, especially breaking strength and breaking elongation, to ensure that the whitening tooth strip is not easy to break during use and removal.

[0051] In a specific embodiment, the thickener in the embodiment of the present application is one of sodium cellulose, hydroxyethyl cellulose or hydroxypropyl methyl cellulose.

[0052] It should be noted that the thickener increases the consistency of the gel layer, making the gel layer of the whitening tooth paste easier to apply and process.

[0053] In a specific embodiment, the purity of the medical alcohol in the embodiment of the present application is 75%.

[0054] It should be noted that the medical alcohol acts as a solvent to increase the solubility of the permeable polyacrylate copolymer film-forming agent and ensure that the permeable polyacrylate copolymer film-forming agent is completely dissolved.

[0055] In a specific embodiment, the conductivity of the purified water in the embodiment of the present application is lower than 1 μS / cm.

[0056] It should be noted that purified water acts as a solvent to increase the solubility of the permeable polyacrylate copolymer film-forming agent and ensure that the permeable polyacrylate copolymer film-forming agent is completely dissolved.

[0057] In a specific embodiment, the moisturizer in the embodiment of the present application is one of glycerol, propylene glycol or sorbitol.

[0058] It should be noted that the moisturizer plays the role of retaining the solvent, preventing the solvent medical alcohol or purified water from completely evaporating, causing the gel layer of the whitening tooth strip to become hard or brittle.

[0059] In a specific embodiment, the whitening agent in the embodiment of the present application is one of urea peroxide, phthalimide peroxycaproic acid, hydrogen peroxide, sodium phytate or sodium hypochlorite.

[0060] It should be noted that whitening agents can whiten teeth by improving the whiteness of the tooth surface through physical stain removal and chemical oxidation.

[0061] In a specific embodiment, the pH adjuster in the embodiment of the present application is one of sodium hydroxide, sodium tripolyphosphate, triethanolamine or potassium dihydrogen phosphate.

[0062] It should be noted that the pH adjuster plays a role in stabilizing the distribution of components, avoiding distribution changes between components due to surface segregation effects, which would affect the teeth whitening effect.

[0063] In a specific embodiment, the sweetener in the embodiment of the present application is one of sucralose, saccharin sodium or steviol glycoside.

[0064] It should be noted that the sweetener serves to increase the sweetness of the gel layer and improve the user experience.

[0065] In a specific embodiment, the taste regulator in the embodiment of the present application is one of citric acid, sodium citrate, potassium citrate or malic acid.

[0066] It should be noted that the taste regulator plays a role in regulating the taste of the gel layer, providing users with more taste options.

[0067] In a specific embodiment, the desensitizing agent in the embodiment of the present application is one of potassium nitrate, strontium citrate or hydroxyapatite.

[0068] It should be noted that desensitizing agents have a desensitizing effect, reducing the occurrence of tooth sensitivity in users.

[0069] In a specific embodiment, the stabilizer in the embodiment of the present application is one of ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetic acid or tartaric acid.

[0070] It should be noted that the stabilizer plays the role of stabilizing the whitening agent to prevent the whitening agent from decomposing too quickly during storage, reducing the effective content of the whitening agent, and thus affecting the whitening effect.

[0071] In a specific embodiment, the flavoring agent in the embodiment of the present application is one of menthol, mint flavor, daily chemical flavor, floral flavor or fruity flavor.

[0072] It should be noted that the flavoring agent plays a role in regulating the flavor of the gel layer, providing users with more flavor options.

[0073] In a second aspect, the present application provides a method for preparing the residue-free whitening tooth paste according to the first aspect, the preparation method comprising:

[0074] The permeable polyacrylate copolymer film-forming agent of claim 2, a tackifier, a thickener, medical alcohol, purified water, a moisturizer, a whitening agent, a pH adjuster, a sweetener, a taste adjuster, a desensitizer, a stabilizer and a flavoring agent are mixed and then subjected to vacuum homogenization and emulsification treatment to obtain a gel;

[0075] The gel is coated on the PET film substrate by coating, the adhesive is placed in a drying device for drying, and then the PE soft film is covered on the surface of the gel by embossing to obtain the residue-free whitening tooth paste.

[0076] It should be noted that 0.5 to 15.0 parts of a permeable acrylic copolymer film-forming agent, 2.0 to 35.0 parts of a tackifier, 0.1 to 15.0 parts of a thickener, 10.0 to 50.0 parts of medical alcohol, 10.0 to 50.0 parts of purified water, 0.5 to 15.0 parts of a moisturizer, 0.1 to 15.0 parts of a whitening agent, 0.01 to 2.0 parts of a pH adjuster, 0.01 to 0.30 parts of a sweetener, 0.01 to 0.40 parts of a taste adjuster, and 0.01 to 0.40 parts of a desensitizing agent are used. 0.01-5.0 parts of an agent, 0.001-0.10 parts of a stabilizer, and 0.05-1.50 parts of a flavoring agent are added into a vacuum homogenizing emulsifying pot, and homogenized and emulsified at 25-30° C. and 0.1 MPa for 2.0 hours to obtain a gel, and the gel is evenly coated on a PET film backing by a coating machine, and then the patch is placed in a drying device at 60° C.-80° C. for drying, and then a PE soft film is embossed and covered on the surface of the gel layer by a three-roll calender to obtain the residue-free whitening tooth patch.

[0077] The technical method of the present application will be further described below in conjunction with specific embodiments.

[0078] Example 1

[0079] This embodiment 1 provides a method for preparing a residue-free whitening tooth paste 1, and the specific steps are as follows:

[0080] 1) Preparation of penetrating polyacrylate copolymer film-forming agent 1: 500.0 mol parts of purified water, 5.0 mol parts of trimethylaminoethyl methacrylate chloride, 0.25 mol parts of OP-10, 0.12 mol parts of hexadecyltrimethylammonium bromide and 0.12 mol parts of isooctyl thioglycolate were added to a dry glass reactor in sequence, and mechanically stirred at room temperature for 0.50 hours. The glass reactor was heated to 65° C. at a heating rate of 10° C. per minute, and 0.050 mol parts of ammonium persulfate were added. The reaction was stirred mechanically at 65° C. for 1.0 hour. Then, 15.50 mol parts of methyl methacrylate, 5.50 mol parts of lauryl acrylate, 3.0 mol parts of methacrylic acid were added dropwise to the glass reactor. A mixed solution consisting of dimethylaminoethyl methacrylate, 3.0 molar parts of ethyl acetoacetate methyl methacrylate and 9.20 molar parts of 2-hydroxypropyl methacrylate was added within 1.0 hour, and then 0.05 molar parts of ammonium persulfate were added, and the mixture was stirred mechanically at a constant temperature of 65°C for 1.0 hour. Then 0.02 molar parts of ammonium persulfate were added, and the glass reactor was heated to 80°C at a heating rate of 10°C per minute, and the mixture was stirred mechanically at a constant temperature of 80°C for 3.0 hours. The mixture was cooled to room temperature and filtered with a 200-mesh nylon cloth. The material was discharged, and the filtrate was washed 3 times with 300.0 molar parts of purified water, and then the filtrate was vacuum dried at 60°C for 48.0 hours, i.e., the permeable polyacrylate copolymer film-forming agent 1.

[0081] 2) Preparation of a residue-free whitening tooth patch 1: adding 0.5 parts of a permeable polyacrylate copolymer film-forming agent 1, 2.0 parts of polyvinyl pyrrolidone, 0.1 parts of sodium cellulose, 10.0 parts of medical alcohol, 10.0 parts of purified water, 0.5 parts of glycerol, 0.1 parts of urea peroxide, 0.01 parts of sodium tripolyphosphate, 0.01 parts of sucralose, 0.01 parts of citric acid, 0.01 parts of potassium nitrate, 0.001 parts of ethylenediaminetetraacetic acid, and 0.05 parts of menthol into a vacuum homogenizing emulsifier, homogenizing and emulsifying at 25°C and 0.1 MPa for 2.0 hours to obtain a gel, and coating the gel evenly on a PET film backing with a coating machine, and then drying the patch in a drying device at 60°C-80°C, and then embossing a PE soft film on the surface of the gel layer with a three-roll calender to obtain a residue-free whitening tooth patch 1.

[0082] Example 2

[0083] This embodiment 2 provides a method for preparing a residue-free whitening tooth paste 2, and the specific steps are as follows:

[0084] 1) Preparation of penetrating polyacrylate copolymer film-forming agent 2: 500.0 mol parts of purified water, 5.0 mol parts of trimethylaminoethyl methacrylate chloride, 0.25 mol parts of OP-10, 0.12 mol parts of hexadecyltrimethylammonium bromide and 0.12 mol parts of isooctyl thioglycolate were added to a dry glass reactor in sequence, and mechanically stirred at room temperature for 0.50 hours. The glass reactor was heated to 70° C. at a heating rate of 10° C. per minute, and 0.050 mol parts of ammonium persulfate were added. The reaction was stirred mechanically at 70° C. for 1.0 hour, and then 15.50 mol parts of methyl methacrylate, 5.50 mol parts of lauryl acrylate, 3.0 mol parts of methacrylic acid were added dropwise to the glass reactor. A mixed solution consisting of dimethylaminoethyl methacrylate, 3.0 molar parts of ethyl acetoacetate methyl methacrylate and 9.20 molar parts of 2-hydroxypropyl methacrylate was added within 1.0 hour, and then 0.05 molar parts of ammonium persulfate was added, and the reaction was carried out by mechanical stirring at a constant temperature of 70°C for 1.0 hour, and then 0.02 molar parts of ammonium persulfate was added, and the glass reactor was heated to 85°C at a heating rate of 10°C per minute, and the reaction was carried out by mechanical stirring at a constant temperature of 85°C for 3.0 hours, and then cooled to room temperature, filtered with a 200-mesh nylon cloth, and the material was discharged. The filtrate was washed with 300.0 molar parts of purified water 3 times, and then the filtrate was vacuum dried at 60°C for 48.0 hours, that is, the permeable polyacrylate copolymer film-forming agent 2.

[0085] 2) Preparation of a residue-free whitening tooth patch 2: 15.0 parts of a permeable polyacrylate copolymer film-forming agent 2, 35.0 parts of polyvinyl pyrrolidone, 15.0 parts of sodium cellulose, 50.0 parts of medical alcohol, 50.0 parts of purified water, 15.0 parts of glycerol, 15.0 parts of urea peroxide, 2.0 parts of sodium tripolyphosphate, 0.30 parts of sucralose, 0.40 parts of citric acid, 5.0 parts of potassium nitrate, 0.10 parts of ethylenediaminetetraacetic acid, and 1.50 parts of menthol were added into a vacuum homogenizing emulsifier, and homogenized and emulsified at 30°C and 0.1 MPa for 2.0 hours to obtain a gel, and the gel was evenly coated on a PET film backing by a coating machine, and then the patch was placed in a drying device at 60°C-80°C for drying, and then a PE soft film was embossed and covered on the surface of the gel layer by a three-roll calender to obtain a residue-free whitening tooth patch 2.

[0086] Comparative Example 1

[0087] This comparative example 1 provides a method for preparing a whitening tooth paste 3, and the specific steps are as follows:

[0088] 0.5 parts of polyvinyl alcohol film-forming agent with a viscosity of 70.0 mpas, 2.0 parts of polyvinyl pyrrolidone, 0.1 parts of sodium cellulose, 10.0 parts of medical alcohol, 10.0 parts of purified water, 0.5 parts of glycerol, 0.1 parts of urea peroxide, 0.01 parts of sodium tripolyphosphate, 0.01 parts of sucralose, 0.01 parts of citric acid, 0.01 parts of potassium nitrate, 0.001 parts of ethylenediaminetetraacetic acid, and 0.05 parts of menthol were added into a vacuum homogenizing emulsifying pot, and homogenized and emulsified at 25°C and 0.1 MPa for 2.0 hours to obtain a gel, and the gel was evenly coated on a PET film substrate by a coating machine, and then the paste was placed in a drying equipment at 60°C-80°C for drying, and then a PE soft film was embossed and covered on the surface of the gel layer by a three-roll calender to prepare a whitening tooth paste 3.

[0089] Comparative Example 2

[0090] This comparative example 2 provides a method for preparing a whitening tooth paste 4, and the specific steps are as follows:

[0091] 50.0 parts of polyvinyl pyrrolidone, 15.0 parts of sodium cellulose, 50.0 parts of medical alcohol, 50.0 parts of purified water, 15.0 parts of glycerol, 15.0 parts of urea peroxide, 2.0 parts of sodium tripolyphosphate, 0.30 parts of sucralose, 0.40 parts of citric acid, 5.0 parts of potassium nitrate, 0.10 parts of ethylenediaminetetraacetic acid, and 1.50 parts of menthol were added into a vacuum homogenizing emulsifying pot, and homogenized and emulsified at 30°C and 0.1 MPa for 2.0 hours to obtain a gel, and the gel was evenly coated on a PET film backing by a coating machine, and then the patch was placed in a drying equipment at 60°C-80°C for drying, and then a PE soft film was embossed and covered on the surface of the gel layer by a three-roll calender to prepare a whitening tooth patch 4.

[0092] Performance testing

[0093] Test 1: Whitening strip strength performance test

[0094] The experimental conditions are as follows: Shanghai Hengyi tensile and compression testing machine (HY-0580 (DB)) was used for measurement. At room temperature, the tooth paste sample with the bottom lining removed was clamped between the upper and lower clamps for tensile testing under set tensile conditions. The effective initial length between the clamps was 40 mm, and the speed of the clamp movement was 100 m / min. The tensile strength was determined based on the tensile tension at the final break and the size of the initial sample cross-section, that is, the tensile strength at the final break. The elongation at break is the maximum tensile length of the sample between the clamps minus the effective initial length of the sample between the clamps divided by the effective initial length of the sample between the clamps. The sample was tested 10 times and the average value was taken. The test results are shown in Table 1.

[0095] Test 2: Fracture of tooth paste after use

[0096] After the backing was removed from the whitening tooth strips prepared in the above examples and comparative examples, actual application tests were carried out respectively. The tooth strips were attached to the tooth surface and peeled off after 15 minutes to record whether there was any breakage residue. Each group of samples was tested 10 times and the average value was taken. The test results are shown in Table 2.

[0097] Test 3: Release rate of whitening ingredients from tooth strips

[0098] In an indoor environment at a temperature of 25°C, the whitening tooth strips were pasted on a glass slide and then immersed in a beaker containing 1L of purified water, with the glass slide parallel to the wall of the beaker. The changes in the peroxide concentration in the water were monitored from the time the sample was immersed, and the concentrations were measured at 10min, 30min, and 1h using an RQflex reflectometer. After 1h, the whitening tooth strips were dissolved in ethyl acetate, and the dissolved tooth strips were added to a beaker containing 1L of purified water, stirred evenly, and the total concentration of the whitening component (peroxide) in the tooth strips was measured. At the same time, the concentration dissolution rate (the value of the peroxide concentration in the water as a percentage of the total concentration) at each measurement time point was calculated.

[0099] Test 4: Whitening effect test of tooth strips

[0100] Maxillary premolars extracted for orthodontic treatment within 30 days were selected, and the tooth surface color difference (L* value) was measured using a spectrocolorimeter. The teeth were then wrapped with whitening tape and immersed in a beaker containing 100 ml of purified water, and then taken out after immersion at 37°C for 2.0 hours, and the tooth surface color difference (L* value) was measured using a spectrocolorimeter. The whitening effect was evaluated based on the change in L* value (△L) before and after immersion treatment.

[0101] The test results are shown in Table 1:

[0102] Table 1: Whitening strips performance test results

[0103]

[0104] The test results show that there is no residual phenomenon of fracture when peeling off the embodiment 1-2, while there is residual fracture in the comparative example 1-2, and the comparative example 2 has poor plasticity and poor adhesion to the tooth surface, which shows that the whitening tooth paste prepared by the embodiment 1-2 has excellent no-residue performance. In addition, the dissolution rate of the whitening component of the embodiment 1-2 increases uniformly, indicating that the tooth paste has excellent continuous whitening performance. Finally, the whitening effect of the whitening tooth paste of the embodiment 1-2 is significantly higher than that of the comparative example 1-2.

[0105] The above is only a specific implementation of the present application, but the protection scope of the present application is not limited thereto. Any person skilled in the art who is familiar with the present technical field can easily think of changes or substitutions within the technical scope disclosed in the present application, which should be included in the protection scope of the present application. Therefore, the protection scope of the present application should be based on the protection scope of the claims.

Claims

1. A residue-free whitening tooth paste, characterized in that: The whitening tooth paste comprises the following components in parts by weight: Provided are 0.5-15.0 parts of a permeable acrylic copolymer film-forming agent, 2.0-35.0 parts of a tackifier, 0.1-15.0 parts of a thickener, 10.0-50.0 parts of medical alcohol, 10.0-50.0 parts of purified water, 0.5-15.0 parts of a moisturizer, 0.1-15.0 parts of a whitening agent, 0.01-2.0 parts of a pH regulator, 0.01-0.30 parts of a sweetener, 0.01-0.40 parts of a taste regulator, 0.01-5.0 parts of a desensitizer, 0.001-0.10 parts of a stabilizer, and 0.05-1.50 parts of a flavoring agent.

2. The residue-free whitening tooth paste according to claim 1, characterized in that: The permeable polyacrylate copolymer film-forming agent is prepared by the following method: 500.0 mol parts of purified water, 5.0 mol parts of trimethylaminoethyl methacrylate chloride, 0.25 mol parts of OP-10, 0.12 mol parts of hexadecyltrimethylammonium bromide and 0.12 mol parts of isooctyl thioglycolate were added to a dried glass reactor in sequence, and mechanical stirring was performed at room temperature for 0.50 hours. The glass reactor was heated to 65-70° C. at a heating rate of 10° C. per minute, and 0.050 mol parts of ammonium persulfate were added. The reaction was stirred mechanically at a constant temperature of 65-70° C. for 1.0 hour. Then, 15.50 mol parts of methyl methacrylate, 5.50 mol parts of lauryl acrylate, 3.0 mol parts of dimethylaminoethyl methacrylate, 3.0 mol parts of ethylhexyl methacrylate were added dropwise to the glass reactor. A mixed solution consisting of ethyl acetoacetate methyl acrylate and 9.20 mole parts of 2-hydroxypropyl methacrylate is dripped in 1.0 hour, then 0.05 mole parts of ammonium persulfate is added, and the mixture is stirred mechanically at a constant temperature of 65-70° C. for 1.0 hour, then 0.02 mole parts of ammonium persulfate is added, the glass reactor is heated to 80-85° C. at a heating rate of 10° C. per minute, and the mixture is stirred mechanically at a constant temperature of 80-85° C. for 3.0 hours, then cooled to room temperature, filtered with a 200-mesh nylon cloth, discharged, and the filtrate is washed three times with 300.0 mole parts of purified water, and then the filtrate is vacuum dried at 60° C. for 48.0 hours to collect the permeable polyacrylate copolymer film-forming agent.

3. The residue-free whitening tooth paste according to claim 1, characterized in that: The tackifier is one of polyvinyl pyrrolidone and polyvinyl alcohol.

4. The residue-free whitening tooth paste according to claim 1, characterized in that: The thickener is one of sodium cellulose, hydroxyethyl cellulose or hydroxypropyl methyl cellulose.

5. The residue-free whitening tooth paste according to claim 1, characterized in that: The purity of the medical alcohol is 75%.

6. The residue-free whitening tooth paste according to claim 1, characterized in that: The conductivity of the purified water is lower than 1 μS / cm.

7. The residue-free whitening tooth paste according to claim 1, characterized in that: The moisturizing agent is one of glycerin, propylene glycol or sorbitol.

8. The residue-free whitening tooth paste according to claim 1, characterized in that: The whitening agent is one of carbamide peroxide, phthalimide peroxycaproic acid, hydrogen peroxide, sodium phytate or sodium hypochlorite.

9. The residue-free whitening tooth paste according to claim 1, characterized in that: The pH regulator is one of sodium hydroxide, sodium tripolyphosphate, triethanolamine or potassium dihydrogen phosphate.

10. The residue-free whitening tooth paste according to claim 1, characterized in that: The sweetener is one of sucralose, saccharin sodium or steviol glycoside.

11. The residue-free whitening tooth paste according to claim 1, characterized in that: Said The taste regulator is one of citric acid, sodium citrate, potassium citrate or malic acid.

12. The residue-free whitening tooth paste according to claim 1, characterized in that: The desensitizing agent is one of potassium nitrate, strontium citrate or hydroxyapatite.

13. The residue-free whitening tooth paste according to claim 1, characterized in that: The stabilizer is one of ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetate or tartaric acid.

14. The residue-free whitening tooth paste according to claim 1, characterized in that: The flavoring agent is one of menthol, mint essence, daily chemical essence, floral essence or fruity essence.

15. A method for preparing the residue-free whitening tooth paste according to any one of claims 1 to 14, characterized in that: include: The permeable polyacrylate copolymer film-forming agent of claim 2, a tackifier, a thickener, medical alcohol, purified water, a moisturizer, a whitening agent, a pH adjuster, a sweetener, a taste adjuster, a desensitizer, a stabilizer and a flavoring agent are mixed and then subjected to vacuum homogenization and emulsification treatment to obtain a gel; The gel is coated on the PET film substrate by coating, the adhesive is placed in a drying device for drying, and then the PE soft film is covered on the surface of the gel by embossing to obtain the residue-free whitening tooth paste.

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