Thrombin solution virus inactivation device

Abstract

The invention discloses a thrombin solution virus inactivation device which comprises a first pump body and a rack, the input end of the first pump body is communicated with a liquid storage device used for storing a thrombin solution through a liquid inlet pipe, the output end of the first pump body is provided with a first liquid outlet pipe, and the middle position of the rack is provided with a protective shell; a light-transmitting cylinder used for containing a thrombin solution is arranged in the protective shell, a plurality of semicircular protrusions playing a role in stirring liquid are arranged on the inner wall of the light-transmitting cylinder in a staggered mode, an auxiliary transmission wheel is fixedly installed at one end of the light-transmitting cylinder, and a first liquid outlet pipe penetrates through the auxiliary transmission wheel and extends into the light-transmitting cylinder. A plurality of ultraviolet lamps which are annularly distributed are arranged between the light-transmitting cylinder and the protective shell, a driving motor is installed at the top of the rack, a main transmission wheel corresponding to the auxiliary transmission wheel is fixedly connected to the output end of the driving motor, and the main transmission wheel and the auxiliary transmission wheel are in transmission connection through a transmission belt; when the light-transmitting cylinder rotates, a turbulent flow effect can be generated on a thrombin solution in the light-transmitting cylinder, the solution is promoted to be turned over more uniformly, a refraction effect can also be generated on ultraviolet light, the optical path length is increased, the ultraviolet light can make more sufficient contact with the solution, and therefore the virus inactivation efficiency is improved.

Description

Technical Field

[0001] The invention belongs to the technical field of virus inactivation devices, in particular to a thrombin solution virus inactivation device. Background Art

[0002] Thrombin is a key serine protease that plays a vital role in the blood coagulation process. It is mainly activated in the blood by activated factor II (i.e. prothrombin), and this process is part of the body's natural hemostasis mechanism. When tissue damage causes rupture of the blood vessel wall, thrombin will quickly aggregate at the wound and catalyze the conversion of fibrinogen into insoluble fibrin to form a stable clot, thereby preventing further bleeding. In addition, thrombin can also promote platelet aggregation, further strengthen the clot structure, and ensure effective closure of damaged blood vessels.

[0003] The main ingredient of thrombin solution is thrombin. Clinically, thrombin solution is usually used for local hemostasis, especially in minor surgery or dental surgery, to help control bleeding and promote wound healing.

[0004] The Chinese patent document "CN209075548U, a sandwich sleeve-shaped inactivation tube and its ultraviolet virus inactivation device" includes an inactivation tube body, which is composed of a large-diameter light-transmitting sleeve and a small-diameter light-transmitting sleeve. The large-diameter light-transmitting sleeve is located on the outer peripheral side of the small-diameter light-transmitting sleeve, and the upper and lower ends of the large-diameter light-transmitting sleeve and the small-diameter light-transmitting sleeve are both in the same plane and sealed with a glass plate of a light-transmitting material, and a sealed space is defined between the large-diameter light-transmitting sleeve and the small-diameter light-transmitting sleeve; an inlet for the inflow of liquid to be inactivated is provided at the bottom of the inactivation tube body in a horizontal direction, and an outlet for the outflow of liquid after inactivation is provided at the top of the inactivation tube body in a horizontal direction; the inlet and the outlet are connected to the sealed space.

[0005] However, it uses a spiral UV lamp design, which leads to the problem of uneven light irradiation. Specifically, in the spiral structure, due to the change in the intensity of light at different positions, the virus in some areas may not be effectively inactivated, thus affecting the overall inactivation effect. At the same time, it may be difficult for the device to completely inactivate only by UV light. If you want to completely inactivate, you need long-term UV irradiation, but this will reduce the inactivation efficiency. If you judge whether the virus is inactivated based on the conclusions drawn from the experiment alone, if you directly extract the virus solution after the predetermined time, there may be a risk of incomplete inactivation, which may ultimately lead to substandard product quality. Summary of the invention

[0006] The object of the present invention is to provide a thrombin solution virus inactivation device to solve the problems raised in the above background technology.

[0007] To achieve the above object, the present invention provides the following technical solutions:

[0008] A thrombin solution virus inactivation device comprises a pump body and a frame, wherein the input end of the pump body is connected to a liquid storage device for storing thrombin solution through a liquid inlet pipe, the output end of the pump body is equipped with a liquid outlet pipe, a protective shell is installed in the middle of the frame, a light-transmitting cylinder for placing thrombin solution is arranged in the protective shell, a plurality of semicircular protrusions for stirring the liquid are staggered on the inner wall of the light-transmitting cylinder, a secondary transmission wheel is fixedly installed at one end of the light-transmitting cylinder, the liquid outlet pipe passes through the secondary transmission gear and extends to the inside of the light-transmitting cylinder, the thrombin solution is pumped into the light-transmitting cylinder through the pump body, a plurality of annularly distributed ultraviolet lamps are arranged between the light-transmitting cylinder and the protective shell, and the ultraviolet light emitted by the ultraviolet lamps is used to inactivate the thrombin. The solution virus is inactivated, a driving motor is installed on the top of the frame, and a main driving wheel corresponding to the auxiliary driving wheel is fixedly connected to the output end of the driving motor, and the main driving wheel and the auxiliary driving wheel are connected by a transmission belt, so that the driving motor drives the light-transmitting cylinder to rotate, so that the thrombin solution is continuously flipped as the light-transmitting cylinder rotates, a switch window is provided on the protective shell, and a self-sealing joint corresponding to the light-opening window is installed on the side wall of the light-transmitting cylinder, and the self-sealing joint can be inserted into a sampler to extract the thrombin solution from the inside of the light-transmitting cylinder to detect the virus inactivation effect, and the other end of the light-transmitting cylinder is penetrated by a liquid outlet pipe 2, and the other end of the liquid outlet pipe 2 is connected to a pump body 2, and the thrombin solution after virus inactivation is extracted through the pump body 2;

[0009] The input amount of thrombin solution, virus inactivation time, rotation speed and number of revolutions of the light-transmitting tube and other data of the pre-experiment are input into the control system. The control system controls pump body 1 to pump the thrombin solution from the liquid storage device into the light-transmitting tube according to the input parameters. At the same time, the drive motor is started to rotate the light-transmitting tube at a predetermined speed. When the preset inactivation time is reached, the light-transmitting tube automatically stops rotating. At this time, the self-sealing joint corresponds to the switch window on the protective shell. The staff can open the switch window and use the sampler to insert the self-sealing joint to extract the treated thrombin solution from the light-transmitting tube for inspection. If the inspection result meets the standard, the pump body 2 is started to pump the treated solution into the external liquid storage device. If the inspection result does not meet the standard, the control system controls the light-transmitting tube to continue rotating until the inactivation condition is met.

[0010] Furthermore, the first liquid outlet pipe is provided with a first electronic metering valve, and the second liquid outlet pipe is provided with a second electronic metering valve, which are respectively used to detect and control the inflow and outflow of the thrombin solution.

[0011] Furthermore, a rotating bearing 1 is fixedly installed on the outer end of the auxiliary transmission gear, and the inner ring of the rotating bearing 1 is sealed and clamped with the liquid outlet pipe 1. The liquid outlet end of the light-transmitting tube is fixedly installed with a rotating bearing 2, and the inner ring of the rotating bearing 2 is sealed and clamped with the liquid outlet pipe 2 to ensure that the liquid outlet pipe 1 and the liquid outlet pipe 2 will not rotate together with the light-transmitting tube.

[0012] Furthermore, the inner rings of the rotating bearing 1 and the rotating bearing 2 are both provided with T-slots, sealing rings are placed in the T-slots, and the liquid outlet pipe 1 and the liquid outlet pipe 2 are both provided with inner grooves, and the other end of the sealing ring is stuck in the inner groove to form a sealing structure.

[0013] Furthermore, a fixed bearing is disposed on the second outer sleeve of the rotating bearing, and a support platform for installing the fixed bearing is disposed at the lower end of the protective shell, which is used to rotatably support the other end of the light-transmitting tube.

[0014] Furthermore, sealing gaskets are placed between the first rotating bearing and the auxiliary transmission wheel, between the auxiliary transmission wheel and the light-transmitting cylinder, and between the second rotating bearing and the light-transmitting cylinder to ensure the sealing effect of the device and ensure that the solution does not leak out.

[0015] Furthermore, the sampler includes a top cover, the lower end of which is rotatably connected to a detection cup, one side of the top cover is provided with a sampling needle connected to the detection cup, and the other end of the top cover is provided with a micro diaphragm liquid pump corresponding to the sampling needle, and the thrombin solution is pumped from the sampling needle to the sampling cup through the micro diaphragm liquid pump.

[0016] Furthermore, a manual valve is provided between the sampling needle and the top cover.

[0017] Furthermore, a drawer cabinet capable of receiving ultraviolet light is provided at the lower end of the protective shell, and the sampler after detection is placed in the drawer cabinet to be sterilized and disinfected by ultraviolet light.

[0018] Beneficial effects of the present invention:

[0019] The present invention allows the operator to perform sample testing after each inactivation cycle, ensuring that only qualified products enter the next step of the process, effectively avoiding the generation of unqualified products.

[0020] By staggeredly arranging a number of semicircular protrusions on the inner wall of the light-transmitting cylinder, when the light-transmitting cylinder rotates, it can produce a turbulent effect on the internal thrombin solution, causing the solution to flip more evenly, and can also produce a refraction effect on ultraviolet light, increasing the optical path length, so that the ultraviolet light can contact the solution more fully, thereby improving the efficiency of virus inactivation.

[0021] The ring-shaped distributed UV lamp can provide a more uniform light intensity, ensuring that the viruses in the thrombin solution are evenly and effectively inactivated, reducing the problem of incomplete inactivation caused by uneven light.

[0022] By rotating the light-transmitting cylinder, the thrombin solution is constantly turned over, which increases the contact area and contact time between the solution and the ultraviolet light and improves the inactivation efficiency.

[0023] Other features and advantages of the present invention will be described in detail in the following detailed description. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 : The overall structure of the present invention Figure 1 .

[0025] Figure 2 : The overall structure of the present invention Figure 2 .

[0026] Figure 3 : The cross-sectional view of the present invention Figure 1 .

[0027] Figure 4 : The cross-sectional view of the present invention Figure 2 .

[0028] Figure 5 : The light-transmitting tube of the present invention is connected to the driving motor structure diagram.

[0029] Figure 6 : Exploded view of the connection between the light-transmitting tube and the driving motor of the present invention.

[0030] Figure 7 : A cross-sectional view of a rotary bearing of the present invention.

[0031] Figure 8 : The light-transmitting tube and the driving motor connection structure of the present invention Figure 2 .

[0032] Fig. 9 :The light-transmitting tube of the present invention is connected to the driving motor and exploded Figure 2 .

[0033] Fig.10 : Two cross-sectional views of the rotary bearing of the present invention.

[0034] Fig.11 : Sampling schematic diagram of the present invention.

[0035] Fig.12 : Schematic diagram of sampler of the present invention.

[0036] Figure numerals: 1, pump body 1; 2, frame; 3, liquid storage device; 4, protective shell; 5, drive motor; 6, light-transmitting tube; 7, pump body 2; 9, sampler; 11, liquid inlet pipe; 12, liquid outlet pipe 1; 41, ultraviolet lamp; 42, switch window; 43, drawer cabinet; 44, support platform; 45, Hall sensor; 51, auxiliary transmission wheel; 52, main transmission wheel; 53, transmission belt; 61, self-sealing joint; 62, semicircular protrusion ; 63, rotating bearing one; 64, rotating bearing two; 65, fixed bearing; 66, sealing gasket; 67, magnet; 71, liquid outlet pipe two; 91, top cover; 92, detection cup; 93, sampling needle; 94, micro diaphragm liquid pump; 95, manual valve; 121, inner groove; 122, air inlet pipe; 123, sealing cover; 124, electronic metering valve one; 631, T-slot; 632, sealing ring; 711, electronic metering valve two. DETAILED DESCRIPTION

[0037] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the accompanying drawings in the embodiments of the present invention.

[0038] Please refer to Figure 1-12 ;

[0039] A thrombin solution virus inactivation device comprises a pump body 1 and a frame 2, wherein the input end of the pump body 1 is connected to a liquid storage device 3 for storing thrombin solution through a liquid inlet pipe 11, and a liquid outlet pipe 12 is installed at the output end of the pump body 1, and a protective shell 4 is installed in the middle of the frame 2, and a light-transmitting cylinder 6 for placing the thrombin solution is arranged in the protective shell 4. Preferably, the light-transmitting cylinder 6 is made of synthetic quartz material, which not only has the characteristics of high transparency and good ultraviolet transmittance, but also has a high Mohs hardness grade, which means that the material can withstand certain mechanical stress and is not easy to wear or break, thereby ensuring the stability and durability of the light-transmitting cylinder 6 when rotating. A plurality of semicircular protrusions 62 are staggered on the inner wall of the light-transmitting cylinder 6. The semicircular protrusion 62 is provided to produce a turbulent effect on the internal thrombin solution when the light-transmitting cylinder 6 rotates, so as to promote the solution to flip more evenly. Preferably, the semicircular protrusion 62 and the light-transmitting cylinder 6 are an integrally processed structure without additional seams or connection points. This design not only enhances the overall stability of the structure, but also avoids the risk of contamination caused by seams or welds. Preferably, the semicircular protrusion is concave outside and convex inside. The semicircular protrusion 62 made of synthetic quartz material can also produce a refraction effect on ultraviolet light, increase the optical path length, and make the ultraviolet light more fully contact with the solution, thereby improving the efficiency of virus inactivation. A secondary transmission wheel 51 is fixedly installed at one end of the light-transmitting cylinder 6. The liquid outlet pipe 12 passes through the secondary transmission gear and extends to the inside of the light-transmitting cylinder 6. Through the pump The body 1 pumps the thrombin solution into the light-transmitting cylinder 6. A number of annularly distributed ultraviolet lamps 41 are provided between the light-transmitting cylinder 6 and the protective shell 4. The ultraviolet lamp 41 is a strip-shaped lamp tube. The ultraviolet light emitted by the ultraviolet lamp 41 is used to inactivate the virus in the thrombin solution. It should be noted that the protective shell 4 is made of stainless steel, which can not only prevent ultraviolet light leakage and protect the safety of the operator, but also its firmness enables the protective shell 4 to be used for a long time. The two ends of the protective shell 4 are designed to be detachable, which is convenient for the installation and maintenance of internal components. A drive motor 5 is installed on the top of the frame 2. The drive motor 5 is a common device and will not be described in detail here. The output end of the drive motor 5 is fixedly connected to a main drive wheel 52 corresponding to the auxiliary drive wheel 51. The main drive wheel 52 and the auxiliary drive wheel 51 are connected to the main drive wheel 52. The auxiliary transmission wheel 51 is connected through the transmission belt 53, so that the driving motor 5 drives the light-transmitting cylinder 6 to rotate, so that the thrombin solution is constantly turned over with the rotation of the light-transmitting cylinder 6, ensuring that part of the solution is fully in contact with the ultraviolet light, thereby improving the effect of inactivating viruses. A switch window 42 is provided on the protective shell 4, and the switch window 42 is in a normally closed state. A self-sealing joint 61 corresponding to the switch window 42 is installed on the side wall of the light-transmitting cylinder 6. When the switch window 42 is opened, the self-sealing joint 61 can be inserted into the sampler 9 to extract and test the thrombin solution in the light-transmitting cylinder 6. The self-sealing joint 61 is used to extract the treated thrombin solution from the light-transmitting cylinder 6 for inspection without destroying the sealing performance. An elastic sealing member is provided inside the self-sealing joint 61. When the sampling needle 93 is inserted,The seal will be squeezed open, allowing the solution to flow out; once the sampling needle 93 is pulled out, the seal will immediately return to its original state, re-seal the joint, and maintain the sealed state of the internal environment of the light-transmitting tube 6. It is explained here that the ultraviolet lamp 41 irradiates the thrombin solution for a certain period of time, with the position corresponding to the self-sealing joint 61 and the switch window 42 as the initial position, and the drive motor 5 will drive the light-transmitting tube 6 to rotate a fixed number of circles according to the irradiation time. After rotating to this number of circles, the drive motor 5 stops to ensure that the self-sealing interface corresponds to the switch window 42. For example, it takes 5 minutes to inactivate the virus in the thrombin solution. After the ultraviolet lamp 41 irradiates for 5 minutes, the drive motor 5 continues to rotate to the initial position and stops rotating. When the drive motor 5 stops rotating, the ultraviolet lamp 41 stops irradiating. Thereafter, the operator can use the sampler 9 to insert the self-sealing joint 61 into the light-transmitting tube. 6 extracts thrombin solution from the inside to test the virus inactivation effect, so as to prevent the ultraviolet light emitted by the ultraviolet lamp 41 from causing harm to the human body. The other end of the light-transmitting tube 6 is provided with a second liquid outlet pipe 71, and the other end of the second liquid outlet pipe 71 is connected to a second pump body 7. If the virus inactivation effect of the thrombin solution detected meets the standard, the thrombin solution after virus inactivation is extracted to an external liquid storage device through the second pump body 7. If the virus inactivation effect of the thrombin solution detected does not meet the standard, the switch window 42 is closed, the drive motor 5 and the ultraviolet lamp 41 are turned on, and the above settings are repeated for repeated inactivation until the inactivation conditions are met. At the same time, since the inactivation effect of the ultraviolet lamp 41 for 5 minutes is not good, the next inactivation time can be appropriately extended and the number of rotations of the light-transmitting tube 6 can be increased to reduce unnecessary repeated detection.

[0040] Specifically, the optimal input amount of thrombin solution, the required virus inactivation time, the rotation speed and the number of revolutions of the light-transmitting cylinder 6 are determined in advance by experiments, and these data are input into the control system, the control system starts the pump body 1 according to the input parameters, and the thrombin solution in the liquid storage device 3 is pumped into the light-transmitting cylinder 6 by the preset amount, and at the same time, the control system activates the drive motor 5, and the drive motor 5 drives the secondary transmission wheel 51 through the transmission belt 53, so that the light-transmitting cylinder 6 starts to rotate according to the preset speed. The rotation of the light-transmitting cylinder 6 prompts the solution to churn therein, ensuring that the partial solution is fully contacted with the ultraviolet light, and in the process of the rotation of the light-transmitting cylinder 6, the ultraviolet lamp 41 continuously emits ultraviolet light, and the virus in the solution is inactivated. After reaching the preset inactivation time and the light-transmitting cylinder 6 rotates to the initial position, the control system will control the motor to stop, so that the light-transmitting cylinder 6 is stationary, and after the light-transmitting cylinder 6 stops rotating, the self-sealing joint 61 is aligned with the switch window 42 on the protective shell 4. At this time, the staff can open the switch window 42, and use the sampler 9 to extract the treated solution from the light-transmitting tube 6 through the self-sealing joint 61 for inspection. If the test result shows that the virus inactivation effect of the solution has reached the expected standard, the control system will start the pump body 2 7 to pump the qualified solution to the external liquid storage device. If the test result shows that the virus inactivation effect of the solution does not meet the standard, the control system will start the rotation process of the light-transmitting tube 6 again until the solution meets the inactivation requirements, thereby realizing the automated control of the virus inactivation process of the thrombin solution and improving the virus inactivation effect and work efficiency of the thrombin solution.

[0041] In addition, the ultraviolet lamps 41 are electrically connected to an external control system, and the irradiation wavelength of the ultraviolet lamps 41 can be controlled by the external control system to adapt to different types of virus inactivation requirements and ensure the optimization of the inactivation effect.

[0042] Both the liquid outlet pipe 12 and the liquid outlet pipe 2 71 are L-shaped, and one end thereof extending laterally is located on the lower end surface inside the light-transmitting cylinder 6. This design ensures that the solution can be directly injected into the bottom of the cylinder when entering the light-transmitting cylinder 6 during introduction, thereby avoiding the solution from adhering to the inner wall of the cylinder or generating bubbles, ensuring that the solution is evenly distributed. When being led out, it can be directly drawn out from the bottom of the cylinder, reducing the residual solution at the bottom, ensuring that as much of the treated solution as possible is recovered, and improving the treatment efficiency and thoroughness.

[0043] In one embodiment, a magnet 67 is installed near the self-sealing joint 61 of the light-transmitting tube 6, and a Hall sensor 45 is installed on the inner wall of the protective shell 4. In the initial state, the position of the magnet 67 should correspond to the position of the Hall sensor 45. The Hall sensor 45 senses the position of the magnet 67. When the irradiation time of the ultraviolet lamp 41 reaches the set value, the Hall sensor 45 detects the position of the magnet 67 and transmits the signal to the external control system. After receiving the signal from the Hall sensor 45, the external control system controls the driving motor 5 to decelerate until the position of the magnet 67 coincides with the position of the Hall sensor 45 again. At this time, the self-sealing joint 61 on the light-transmitting tube 6 is just aligned with the switch window 42 on the protective shell 4. When the Hall sensor 45 detects that the magnet 67 returns to the initial position, the control system immediately stops the rotation of the driving motor 5 to ensure that the light-transmitting tube 6 stops at the correct position, so that the self-sealing joint 61 corresponds accurately to the switch window 42, ensuring that the light-transmitting tube 6 can accurately stop at the predetermined position after each inactivation treatment.

[0044] In one embodiment, an electronic metering valve 124 is provided on the liquid outlet pipe 12, and an electronic metering valve 711 is provided on the liquid outlet pipe 71. Before injecting the thrombin solution into the light-transmitting cylinder 6, the electronic metering valve 124 is first closed, and the electronic metering valve 711 is opened. The air in the light-transmitting cylinder 6 is extracted by the pump body 7, and then the electronic metering valve 711 is closed and the electronic metering valve 124 is opened. The thrombin solution can be pumped into the light-transmitting cylinder 6 through the pump body 1. When the virus inactivation of the thrombin solution is completed, the electronic metering valve 711 is opened, and the electronic metering valve 124 is closed to remove the thrombin solution. The thrombin solution is extracted. At the same time, the two electronic metering valves can also be used to detect and control the inlet and outlet amounts of the thrombin solution. When the electronic metering valve 124 detects that the injection amount of the thrombin solution reaches the set amount, the electronic metering valve 124 automatically closes and transmits a signal to the control system, which automatically closes the pump body 1 through the control system to avoid excessive injection of the thrombin solution into the light-transmitting tube 6 and affect the inactivation effect. When the thrombin solution after virus inactivation is extracted, the electronic metering valve 2 711 can detect the outlet amount of the liquid, which is convenient for the operator to observe whether the thrombin solution is completely extracted.

[0045] In addition, when the pump body 2 7 draws liquid, a negative pressure effect will be generated due to insufficient air in the light-transmitting tube 6, resulting in the inability to draw out the solution. For this reason, an air inlet pipe is provided in the pipeline between the electronic metering valve 124 and the light-transmitting tube 6. The air inlet pipe 122 is connected with the liquid outlet pipe 12 to form a three-way pipe structure. An air inlet port is provided on the air inlet pipe 122, and a sealing cover 123 is rotatably connected to the air inlet port. Before the pump body 1 is infused, the sealing cover 123 is screwed on first to prevent the solution from spraying out of the air inlet port. When the pump body 2 7 draws the solution, the sealing cover 123 can be opened to ensure air circulation to ensure smooth extraction of the solution.

[0046] In one embodiment, a rotating bearing 63 is fixedly installed on the outer end of the auxiliary transmission wheel 51, and the inner ring of the rotating bearing 63 is sealed and clamped with the liquid outlet pipe 12, so that the liquid outlet pipe 12 will not be affected by the rotation when the light-transmitting tube 6 rotates, and remains stable and motionless. A rotating bearing 64 is fixedly installed on the liquid outlet end of the light-transmitting tube 6, and the inner ring of the rotating bearing 64 is sealed and clamped with the liquid outlet pipe 71, ensuring that the liquid outlet pipe 71 can remain fixed during the rotation of the light-transmitting tube 6 and will not be affected by the rotation. Such a design not only ensures the stability of the liquid outlet pipe, but also avoids mechanical damage or leakage caused by rotation, thereby improving the reliability and safety of the entire device.

[0047] Furthermore, a T-slot 631 is provided in the inner ring of the rotating bearing 1 63 and the rotating bearing 2 64, and a sealing ring 632 is placed in the T-slot 631. The shape of the sealing ring 632 matches the T-slot 631, which can maintain stability when the rotating bearing rotates to prevent leakage. An inner groove 121 is provided on the liquid outlet pipe 1 12 and the liquid outlet pipe 2 71, and the other end of the sealing ring 632 is stuck in the inner groove 121. This design not only ensures that the liquid outlet pipe is fixed when the light-transmitting tube 6 rotates, but also ensures that no leakage will occur during the rotation process.

[0048] In one embodiment, a fixed bearing 65 is provided on the outer sleeve of the second rotating bearing 64, and a support platform 44 for installing the fixed bearing 65 is provided at the lower end of the protective shell 4. The other end of the light-transmitting tube 6 is rotationally supported by the fixed bearing 65, thereby ensuring the stability of the light-transmitting tube 6 during rotation.

[0049] Since all parts are made of hard materials, there will be gaps at the connection positions of the parts, and the solution may leak from these gaps. For this reason, sealing gaskets 66 are placed between the rotating bearing 1 63 and the auxiliary transmission wheel 51, between the auxiliary transmission wheel 51 and the light-transmitting tube 6, and between the rotating bearing 2 64 and the light-transmitting tube 6. These sealing gaskets 66 effectively isolate the gaps between the various components, ensure that the solution will not leak out from the gaps of the device, and improve the sealing effect of the device.

[0050] In one embodiment, the sampler 9 includes a top cover 91, the lower end of which is rotatably connected to a test cup 92, which can be removed to test the solution, a sampling needle 93 connected to the test cup 92 is provided on one side of the top cover 91, and a micro-diaphragm liquid pump 94 corresponding to the sampling needle 93 is provided on the other end of the top cover 91, preferably a micro-diaphragm liquid pump 94 of model TF30A-A, through which the thrombin solution is pumped into the sampling cup. It is noted that in order to prevent the solution from spraying out, the power of the micro-diaphragm liquid pump 94 should not be set too large, and a tool for collecting the solution is connected to the liquid outlet to ensure safe operation and avoid liquid splashing. In addition, a manual valve 95 is provided between the sampling needle 93 and the top cover 91, and the setting of the manual valve 95 ensures the controllability of the sampling process and avoids waste of the solution.

[0051] In one embodiment, a drawer cabinet 43 capable of receiving ultraviolet light is provided at the lower end of the protective shell 4, and the sampler 9 after detection is placed in the drawer cabinet 43 to be sterilized and disinfected by ultraviolet light.

[0052] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations falling within the meaning and scope of the equivalent elements of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

[0053] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementations that can be understood by those skilled in the art.

Claims

1. A thrombin solution virus inactivation device, comprising a pump body (1) and a frame (2), wherein the input end of the pump body (1) is connected to a liquid storage device (3) for storing thrombin solution through a liquid inlet pipe (11), and the output end of the pump body (1) is provided with a liquid outlet pipe (12), and a protective shell (4) is installed in the middle position of the frame (2), wherein a light-transmitting cylinder (6) for placing the thrombin solution is arranged in the protective shell (4), and a plurality of semicircular protrusions (62) which are concave outside and convex inside are arranged alternately on the inner wall of the light-transmitting cylinder (6), a secondary transmission wheel (51) is fixedly installed at one end of the light-transmitting cylinder (6), the liquid outlet pipe (12) passes through the secondary transmission gear and extends to the inside of the light-transmitting cylinder (6), and a plurality of annularly distributed ultraviolet lamps (41) are arranged between the light-transmitting cylinder (6) and the protective shell (4). ), a driving motor (5) is installed on the top of the frame (2), a main driving wheel (52) corresponding to the auxiliary driving wheel (51) is fixedly connected to the output end of the driving motor (5), the main driving wheel (52) and the auxiliary driving wheel (51) are connected to each other by a transmission belt (53), a switch window (42) is provided on the protective shell (4), a self-sealing joint (61) corresponding to the light-opening window is installed on the side wall of the light-transmitting cylinder (6), the self-sealing joint (61) can be inserted into a sampler (9) to extract thrombin solution from the inside of the light-transmitting cylinder (6) to detect the virus inactivation effect, the other end of the light-transmitting cylinder (6) is penetrated by a second liquid outlet pipe (71), the other end of the second liquid outlet pipe (71) is connected to a second pump body (7), and the thrombin solution after virus inactivation is extracted through the second pump body (7); The input amount of the thrombin solution, the virus inactivation time, the rotation speed and number of revolutions of the light-transmitting cylinder (6) and other data of the pre-experiment are input into the control system. The control system controls the pump body 1 (1) to pump the thrombin solution from the liquid storage device (3) into the light-transmitting cylinder (6) according to the input parameters. At the same time, the drive motor (5) is started to rotate the light-transmitting cylinder (6) at a predetermined speed. When the preset inactivation time is reached, the drive motor stops, causing the light-transmitting cylinder (6) to stop rotating. When the light-transmitting cylinder is in a stationary state, the self-sealing joint (61) corresponds to the switch window (42) on the protective shell (4). The staff can open the switch window (42) and use the sampler (9) to insert the self-sealing joint (61) to extract the treated thrombin solution from the light-transmitting cylinder (6) for inspection. If the inspection result meets the standard, the pump body 2 (7) is started to extract the treated solution into the external liquid storage device. If the inspection result does not meet the standard, the control system controls the light-transmitting cylinder (6) to continue rotating.

2. A thrombin solution virus inactivation device according to claim 1, characterized in that: The liquid outlet pipe 1 (12) is provided with an electronic metering valve 1 (124), and the liquid outlet pipe 2 (71) is provided with an electronic metering valve 2 (711), which are respectively used to detect and control the inflow and outflow of the thrombin solution.

3. A thrombin solution virus inactivation device according to claim 1, characterized in that: A rotating bearing 1 (63) is fixedly mounted on the outer end of the auxiliary transmission gear, and the inner ring of the rotating bearing 1 (63) is sealed and clamped with the liquid outlet pipe 1 (12). A rotating bearing 2 (64) is fixedly mounted on the liquid outlet end of the light-transmitting cylinder (6), and the inner ring of the rotating bearing 2 (64) is sealed and clamped with the liquid outlet pipe 2 (71), so as to ensure that the liquid outlet pipe 1 (12) and the liquid outlet pipe 2 (71) will not rotate together with the light-transmitting cylinder (6).

4. A thrombin solution virus inactivation device according to claim 3, characterized in that: The inner rings of the first rotating bearing (63) and the second rotating bearing (64) are both provided with T-shaped grooves (631), and sealing rings (632) are placed in the T-shaped grooves (631). The first liquid outlet pipe (12) and the second liquid outlet pipe (71) are both provided with inner grooves (121), and the other end of the sealing ring (632) is clamped in the inner groove (121) to form a sealing structure.

5. A thrombin solution virus inactivation device according to claim 4, characterized in that: The outer sleeve of the second rotating bearing (64) is provided with a fixed bearing (65), and the lower end of the protective shell (4) is provided with a support platform (44) for mounting the fixed bearing (65), which is used to rotatably support the other end of the light-transmitting cylinder (6).

6. A thrombin solution virus inactivation device according to claim 5, characterized in that: Sealing pads (66) are placed between the first rotating bearing (63) and the auxiliary transmission wheel (51), between the auxiliary transmission wheel (51) and the light-transmitting cylinder (6), and between the second rotating bearing (64) and the light-transmitting cylinder (6) to ensure the sealing effect of the device and ensure that the solution does not leak out.

7. A thrombin solution virus inactivation device according to claim 1, characterized in that: The sampler (9) comprises a top cover (91), the lower end of which is rotatably connected to a detection cup (92), one side of the top cover (91) is provided with a sampling needle (93) connected to the detection cup (92), and the other end of the top cover (91) is provided with a micro-diaphragm liquid pump (94) corresponding to the sampling needle (93), and the thrombin solution is pumped from the sampling needle (93) to the sampling cup through the micro-diaphragm liquid pump (94).

8. A thrombin solution virus inactivation device according to claim 7, characterized in that: A manual valve (95) is provided between the sampling needle (93) and the top cover (91).

9. A thrombin solution virus inactivation device according to claim 1, characterized in that: The lower end of the protective shell (4) is provided with a drawer cabinet (43) capable of receiving ultraviolet light irradiation, and the sampler (9) after detection is placed in the drawer cabinet (43) to be sterilized and disinfected by ultraviolet light.

Images