Multifunctional cleaning solution

Abstract

The invention discloses a multifunctional cleaning solution, which takes N-long-chain acyl amino acid and basic amino acid as main surfactants, can not contain a thickening agent, ethoxylate, fatty acid salt and a humectant, and has the properties of low irritation, selective cleaning, no stickiness, no dry and tight skin after washing and the like.

Description

Technical Field

[0001] The invention relates to the field of cleaning technology, in particular to a multifunctional cleaning liquid comprising N-long-chain acylamino acid and basic amino acid as main surfactants. Background Art

[0002] In the past two decades, cleaning products have become increasingly segmented in terms of categories, concepts, effects, channels, consumer groups, etc. However, extreme segmentation has also brought troubles to many consumers in terms of selection and use, so the concept of "multi-effects in one" products has been mentioned more and more.

[0003] At present, cleansing, makeup removal, shaving, bathing and shampooing are completely different types of products, with great differences in formula design concepts, raw material combinations, etc.

[0004] For facial cleansing products, they are mainly composed of alcohols (for dissolving, dispersing, etc.), surfactants such as sodium lauroyl glutamate, auxiliary surfactants (for increasing foaming, etc.), fillers such as modified starch (for adjusting the setting point, filling and softening the paste), emulsifiers such as A165 (for emulsifying some unneutralized fatty acids or some alcohols, oils, etc.), moisturizers, preservatives, fragrances, etc.

[0005] For bath products, they are mainly composed of main surfactant (usually sodium laureth sulfate) + auxiliary surfactant (cocamidopropyl betaine, etc.) + thickener + esterifying agent (jojoba oil, etc.) + conditioner (polyols) + additives.

[0006] For shampoo products, the main components are: water + surfactant (the main surfactant is usually sodium laureth sulfate) + thickener + pH adjuster + cationic conditioner + fragrance + chelating agent + preservative, etc. Auxiliary (optional) ingredients: viscosity regulator, anti-dandruff agent, pearlescent agent, moisturizer, pigment, plant extract, etc.

[0007] For makeup remover products, makeup remover oil is mainly composed of light oil + surfactant + functional ingredients, and makeup remover liquid is mainly composed of water + light oil + surfactant + functional ingredients. Makeup remover water is mainly composed of water + surfactant + functional ingredients. Surfactants usually choose polyglycerol ester surfactants. Commonly used surfactants in makeup remover water include: PEG-6 caprylic / capric glycerides, PEG-7 caprylic / capric glycerides, PEG-8 caprylic / capric glycerides, PEG-7 glyceryl cocoate, poloxamer 184, Tween series, etc.

[0008] For shaving products, the formula is generally based on traditional soap emulsification, which is a dispersion system of alkali metal soap in glycerin and water. The emulsifier uses fatty acid salts to produce rich and delicate foam. In order to improve the comfort of the skin, some emollients, moisturizers, cooling agents and astringents are added to the formula.

[0009] On the other hand, with the increasing frequency of shampooing / bathing / makeup removal in recent years, traditional cleansing formulas may sometimes feel dry and irritating, so there is a need for cleansing solutions with less irritation. In addition, petroleum-derived surfactants are contrary to the current sustainable development and environmental protection orientation.

[0010] 1. Sulfate surfactants

[0011] Most current cleaning products are based on sulfate-containing surfactants, such as sodium lauryl sulfate (SLS), ammonium lauryl sulfate (ALS), sodium laureth sulfate (SLES) or ammonium laureth sulfate (ALES). These sulfate surfactants combine the advantages of low price and satisfactory cleaning and foaming properties. However, as described in EP3582748A1, it is known that sulfate-containing surfactants (such as SLS) are prone to tolerance problems, especially on the skin and eyes. Another disadvantage of sulfate-containing surfactants is their tendency to strip the skin, scalp or hair of natural oils, fats or proteins contained at their surface. In the long run, repeated use of personal cleaning products containing sulfate-containing surfactants may cause irritation to the skin or scalp and / or damage to the hair fibers.

[0012] 2. Ethoxylated surfactants

[0013] The most typical ethoxylated surfactant is sodium laureth sulfate (SLES or AES). AES has strong cleaning power and can be easily thickened by adding sodium chloride (adding a large amount of sodium chloride to thicken is convenient, but sodium chloride can irritate the eyes), so it is widely used. Although it is milder than alkyl sulfate, it is still moderately irritating (see GB2598154A). In addition, ethoxylated surfactants contain a large amount of non-renewable carbon from ethylene oxide and have safety issues (dioxane contained in the surfactant is carcinogenic).

[0014] 3. Fatty acid salts

[0015] Fatty acid salts have been used as the main component of human body compositions, such as shower gels, hand soaps and facial cleansers, because they provide good foaming and a refreshing feeling. Fatty acid salts have good cleaning and foaming properties, but can only be made into products with high pH values ​​(>9.0), and they dry and irritate the skin, with a bad skin feel (see GB2598154A, EP3957297A1). Similarly, CN105997546B discloses a cleaning agent composition with fatty acid salts as the main component, which has the problem of tension and dryness peculiar to fatty acid salts after drying.

[0016] 4. Amino Acid Surfactants

[0017] The cosmetics and personal care industry has demonstrated the growing popularity and importance of “sulfate-free” and “dioxane-free” personal care cleaning products containing environmentally friendly, sustainable and mild surfactants. Amino acid-based surfactants are considered to be “greener”, milder and more sustainable than traditional petroleum-based surfactants.

[0018] The development of high-quality environmentally friendly surfactants has become the main direction of the surfactant industry, and the replacement of traditional petroleum-based surfactants with amino acid surfactants is the trend of industry development. Unilever announced that it would halve the use of petroleum-based products by 2025 and reduce the use of petroleum-based products to zero by 2030. L'Oreal announced that by 2030, 95% of petroleum-based products would be replaced. Therefore, it is very necessary to study the formulation system of amino acid surfactants as the main surfactant. Most of the current research focuses on the compounding of amino acid surfactants with traditional petroleum-based surfactants or the thickening of amino acid surfactants. There are few studies on how to reduce skin irritation or eye irritation, improve easy-to-rinse performance, and control oil. In addition, if the traditional formulation method is used, acyl amino acid anionic surfactants as the main cleaning ingredients are easy to make consumers feel sticky (or sticky), which is also a generally undesirable feeling and cannot be used in disposable and dry cleaning products. Summary of the invention

[0019] In view of the fact that the concept of "multi-effect in one" is increasingly mentioned, and there is a widespread demand for low skin irritation / eye irritation and easy rinsing performance, the purpose of the present invention is to provide a facial cleansing liquid, a makeup removing cleansing liquid or a shaving cleansing liquid, or even a multifunctional cleansing liquid covering the above functions. The surfactant contained in the cleansing liquid is mainly N-long-chain acyl amino acids and basic amino acids, which meets the requirements of low irritation, good skin feel, non-sticky, no dryness and tightness of the skin after washing, and easy rinsing.

[0020] Specifically, the scheme of the present invention is as follows.

[0021] [1] A facial cleansing liquid comprising (a) a primary surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the primary surfactant in all surfactants exceeds 50 wt%, preferably exceeds 65 wt%, and more preferably exceeds 80 wt%;

[0022] The main surfactant is composed of N-long chain acyl amino acid and basic amino acid; or, the main surfactant is composed of N-long chain acyl amino acid, N-long chain acyl amino acid dipeptide and basic amino acid.

[0023] [2] A makeup removing cleansing liquid comprising (a) a primary surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the primary surfactant in all surfactants exceeds 50 wt %, preferably exceeds 65 wt %, and more preferably exceeds 80 wt %;

[0024] The main surfactant is composed of N-long chain acyl amino acid and basic amino acid; or, the main surfactant is composed of N-long chain acyl amino acid, N-long chain acyl amino acid dipeptide and basic amino acid.

[0025] [3] A shaving cleansing liquid comprising (a) a primary surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the primary surfactant in all surfactants exceeds 50 wt%, preferably exceeds 65 wt%, and more preferably exceeds 80 wt%;

[0026] The main surfactant is composed of N-long chain acyl amino acid and basic amino acid; or, the main surfactant is composed of N-long chain acyl amino acid, N-long chain acyl amino acid dipeptide and basic amino acid.

[0027] [4] A multifunctional cleaning liquid comprising (a) a primary surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the primary surfactant in all surfactants exceeds 50 wt %, preferably exceeds 65 wt %, and more preferably exceeds 80 wt %;

[0028] The main surfactant is composed of N-long chain acyl amino acid and basic amino acid; or, the main surfactant is composed of N-long chain acyl amino acid, N-long chain acyl amino acid dipeptide and basic amino acid.

[0029] [5] The cleaning solution according to any one of [1] to [4], wherein when the main surfactant is composed of an N-long-chain acyl amino acid and a basic amino acid, the weight percentage of the N-long-chain acyl amino acid in the cleaning solution is 1 to 12 wt%, preferably 4 to 8 wt%, more preferably 5 to 7 wt%, and the weight percentage of the basic amino acid in the cleaning solution is 0.5 to 8 wt%, preferably 2 to 5.5 wt%, more preferably 3 to 5 wt%; or, when the main surfactant is composed of an N-long-chain acyl amino acid, an N-long-chain acyl amino acid dipeptide and a basic amino acid, the total weight percentage of the N-long-chain acyl amino acid and the N-long-chain acyl amino acid dipeptide in the cleaning solution is 1 to 12 wt%, preferably 4 to 8 wt%, more preferably 5 to 7 wt%, and the weight percentage of the basic amino acid in the cleaning solution is 0.5 to 8 wt%, preferably 2 to 5.5 wt%, more preferably 3 to 5 wt%;

[0030] The weight percentage of the co-surfactant in the cleaning solution is 0 to 10 wt %, preferably 0 to 5 wt %, and more preferably 0 to 1 wt %.

[0031] [6] The cleaning solution according to any one of [1] to [5], wherein the cleaning solution contains substantially no thickener, and preferably contains no thickener at all;

[0032] and / or, substantially free of sodium chloride, preferably completely free of sodium chloride;

[0033] and / or, substantially free of sulfates, preferably completely free of sulfates;

[0034] and / or, substantially free of ethoxylates, preferably completely free of ethoxylates;

[0035] and / or, substantially free of fatty acid salts, preferably completely free of fatty acid salts;

[0036] And / or, substantially no polyol humectant is contained, preferably no polyol humectant is contained.

[0037] [7] According to the cleaning liquid described in any one of [1] to [6], the auxiliary surfactant comprises one or more of a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a sodium salt, potassium salt, or TEA salt of an N-long-chain acylamino acid.

[0038] [8] The cleaning liquid according to any one of [1] to [7], wherein the co-surfactant contains substantially no nonionic surfactant, and preferably contains no nonionic surfactant at all.

[0039] [9] The cleaning liquid according to any one of [1] to [8], wherein the co-surfactant contains substantially no cationic surfactant, and preferably contains no cationic surfactant at all.

[0040]

[10] The cleaning liquid according to any one of [1] to [9], wherein the co-surfactant substantially does not contain an amphoteric surfactant, and preferably does not contain an amphoteric surfactant at all.

[0041]

[11] According to any one of [1] to

[10] , the weight percentage of the auxiliary surfactant in the cleaning liquid is 0 wt%, that is, the weight percentage of the main surfactant in all surfactants is 100 wt%.

[0042]

[12] The cleaning liquid according to any one of [1] to

[11] , wherein the N-long-chain acyl group in the N-long-chain acyl amino acid is derived from a saturated or unsaturated linear or branched fatty acid having 8 to 22 carbon atoms;

[0043] And / or, the amino acids in the N-long-chain acyl amino acids are derived from one or more of glycine, alanine, glutamic acid, sarcosine, aspartic acid, leucine, isoleucine, valine, threonine, proline, phenylalanine, arginine, lysine, and (methyl)taurine.

[0044]

[13] The cleaning liquid according to any one of [1] to

[12] , wherein the N-long-chain acyl group in the N-long-chain acyl amino acid is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, and palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, and most preferably lauroyl;

[0045] And / or, the amino acid in the N-long-chain acylamino acid is derived from one or more of alanine, glycine, glutamic acid, sarcosine, arginine, lysine, (methyl)taurine, preferably alanine, most preferably L-alanine.

[0046]

[14] According to any one of [1] to

[13] , the basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, and diaminopropionic acid, preferably arginine and / or lysine, most preferably arginine.

[0047]

[15] The cleaning liquid according to any one of [1] to

[14] , wherein the N-long-chain acyl group in the N-long-chain acyl amino acid dipeptide is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, and palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, and most preferably lauroyl;

[0048] And / or, the amino acids in the N-long-chain acyl amino acid dipeptide are derived from one or more of alanine, glycine, glutamic acid, sarcosine, arginine, lysine, and (methyl)taurine, preferably alanine, and most preferably L-alanine.

[0049]

[16] According to the cleaning liquid according to any one of [1] to

[15] , the N-long-chain acyl amino acid dipeptide is selected from one or more of N-long-chain acyl glycylglycine, N-long-chain acyl glutamyl glutamate, N-long-chain acyl alanyl alanine, and N-long-chain acyl sarcosyl sarcosine, preferably N-long-chain acyl alanyl alanine, and most preferably N-lauroyl-L-alanyl-L-alanine.

[0050]

[17] The cleaning liquid according to any one of [1] to

[16] , wherein the weight percentage of the N-long-chain acyl amino acid dipeptide in the cleaning liquid is greater than 0.1 wt %, preferably greater than 0.3 wt %, and more preferably greater than 0.5 wt %;

[0051] And / or, the weight ratio of N-long-chain acyl amino acid to N-long-chain acyl amino acid dipeptide is 20:1 to 1.5:1, preferably 15:1 to 3:1, more preferably 10:1 to 6:1.

[0052]

[18] The cleaning solution according to any one of [1] to

[17] , wherein the basic amino acid is present in an amount to partially neutralize the N-long-chain acylamino acid, preferably with a neutralization degree of 85% or more and less than 100%, more preferably with a neutralization degree of 88% or more and less than 96%;

[0053] Alternatively, the basic amino acid is present in an amount to partially neutralize the N-long-chain acyl amino acid and N-long-chain acyl amino acid dipeptide, preferably with a neutralization degree of 85% or more and less than 100%, more preferably with a neutralization degree of 88% or more and 96% or less.

[0054]

[19] The cleaning solution according to any one of [1] to

[18] , further comprising (d) a preservative, wherein the preservative is benzoic acid.

[0055]

[20] The cleaning solution according to any one of [1] to

[19] , further comprising (e) a fragrance or an essence, wherein the cleaning solution is preferably clear after the fragrance or the essence is added.

[0056]

[21] The cleaning liquid according to any one of [1] to

[20] , wherein the cleaning liquid does not contain a cationic polymer; and / or the cleaning liquid does not contain silicone oil.

[0057]

[22] The cleaning solution according to any one of [1] to

[21] , wherein the pH of the cleaning solution is 5-7.5, preferably 5.5-6.9, more preferably 6-6.7;

[0058] And / or, the cleaning liquid has a low viscosity, wherein the low viscosity means that the viscosity at 25° C. is lower than 150 mPa·s, preferably lower than 120 mPa·s, and more preferably lower than 100 mPa·s.

[0059]

[23] The cleaning liquid according to any one of [1] to

[22] , wherein the cleaning liquid has a specified cloth detergency according to QB / T1224-2012 Liquid Detergents for Clothing, JB-01 being greater than 0.8, preferably greater than 0.85, and more preferably greater than 0.9;

[0060] and / or, JB-02 is above 0.8, preferably above 0.85, more preferably above 0.9;

[0061] And / or, JB-03 is 0.4 or more and 0.8 or less, preferably 0.45 or more and 0.75 or less, and more preferably 0.5 or more and 0.7 or less.

[0062]

[24] The cleaning liquid according to any one of [1] to

[23] has better foam performance in hard water than in soft water; and / or, under hard water conditions, the foam volume in 30s, 3min and 5min exceeds 400ml, preferably exceeds 450ml, and more preferably exceeds 500ml; the aforementioned test standard: GB / T7462-1994 "Determination of Foaming Power of Surfactants - Improved Ross-Miles Method", test instrument: Model 2152 Improved Ross Foam Tester.

[0063]

[25] The cleaning liquid according to any one of [1] to

[24] , wherein the cleaning liquid comprises (a) a primary surfactant, (c) water, (d) a preservative, and (e) a flavor; wherein the primary surfactant comprises an N-long-chain acyl amino acid and a basic amino acid, the weight percentage of the N-long-chain acyl amino acid in the cleaning liquid is 5 to 7 wt%, and the weight percentage of the basic amino acid in the cleaning liquid is 3 to 5 wt%; or, the primary surfactant comprises an N-long-chain acyl amino acid, an N-long-chain acyl amino acid dipeptide, and a basic amino acid, the total weight percentage of the N-long-chain acyl amino acid and the N-long-chain acyl amino acid dipeptide in the cleaning liquid is 5 to 7 wt%, and the weight percentage of the basic amino acid in the cleaning liquid is 3 to 5 wt%;

[0064] Preferably, (d) the preservative is benzoic acid.

[0065] Compared with the prior art, the present invention has beneficial technical effects:

[0066] 1. Use N-long-chain acylamino acids and alkaline amino acids as the main surfactants, and limit the amount of surfactants to a reasonable range, so that the cleaning solution has the properties of low irritation, selective cleaning / decontamination, and non-stickiness.

[0067] 2. By screening specific main surfactants, especially a combination of N-long-chain acyl amino acids (optional dipeptides) and basic amino acids, the cleaning solution can be substantially free of nonionic surfactants, cationic surfactants, and amphoteric surfactants while meeting performance requirements, because the more auxiliary surfactants added, the greater the adverse effects on washing feel, skin feel, irritation, and rinsing ease.

[0068] 3. The present invention unexpectedly found that benzoic acid has very good antiseptic properties and compatibility in the system of the present invention, and its irritation is lower than other preservatives such as sodium benzoate.

[0069] 4. The cleaning liquid of the present invention still achieves a relatively excellent decontamination effect and even achieves selective decontamination without containing traditional petroleum-based surfactants.

[0070] 5. The present invention is the first to discover that selecting a main surfactant composed of N-long-chain acyl amino acids (optional dipeptide) and basic amino acids without adding thickeners, polyol moisturizers, etc. can reduce skin irritation or eye irritation, and can improve rinseability, and even achieve no-washing. BRIEF DESCRIPTION OF THE DRAWINGS

[0071] Figure 1 This is a graph showing the results of a makeup removal test using an aqueous solution of sodium lauroyl glutamate, an aqueous solution of potassium cocoyl glycinate, and an aqueous solution of sodium lauroyl sarcosinate in Example 4, wherein ① is a comparison before and after treatment with an aqueous solution of sodium lauroyl glutamate; ② is a comparison before and after treatment with an aqueous solution of potassium cocoyl glycinate; and ③ is a comparison before and after treatment with an aqueous solution of sodium lauroyl sarcosinate.

[0072] Figure 2 This is a graph showing the results of a makeup removal test using the lauroyl alanine arginine aqueous solution in Example 4; ④ in the figure is a comparison before and after treatment with the lauroyl alanine arginine aqueous solution.

[0073] Figure 3 This is a diagram showing the results of the foam test in Example 5.

[0074] Figure 4 This is a diagram showing the cleaning effect of the facial cleansing solution of Example 10.

[0075] Figure 5 1 is a diagram showing the makeup removal effect of the makeup removing cleaning liquid of Example 11, in which a1 is lipstick, a2 is eyebrow powder, a3 is blush, and a4 is eye shadow; b is a diagram showing the effect of applying the makeup removing cleaning liquid of Example 11; and c is a diagram showing the effect after treatment with the makeup removing cleaning liquid of Example 11.

[0076] Figure 6 1 is a comparison diagram of the shaving cleaning liquid of Example 12 and a commercially available shaving cleaning liquid after use, wherein ① shows the shaving cleaning liquid of Example 12 remaining on the razor, and ② shows the commercially available shaving cleaning liquid remaining on the razor. DETAILED DESCRIPTION

[0077] In one embodiment, a facial cleansing liquid is provided, which comprises (a) a primary surfactant, (b) a co-surfactant, and (c) water.

[0078] The so-called primary surfactant refers to the surfactant with the highest content among all surfactants in terms of weight percentage. Further, the weight percentage of the primary surfactant in all surfactants exceeds 50wt%, preferably exceeds 65wt%, and more preferably exceeds 80wt%; for example, exceeds 55wt%, 60wt%, 65wt%, 70wt%, 75wt%, 80wt%, 85wt%, 90wt%, 95wt%. In some examples, the content of the primary surfactant can reach 100%, that is, no co-surfactant is used at all.

[0079] For component (a), the main surfactant is composed of N-long-chain acyl amino acids and basic amino acids. Those skilled in the art will understand that there is no essential difference whether the N-long-chain acyl amino acids and basic amino acids are added independently or the basic amino acid salts of the N-long-chain acyl amino acids are reacted first and then added, and it is also covered by the scope of "composed of N-long-chain acyl amino acids and basic amino acids".

[0080] The weight percentage of N-long-chain acylamino acid in the cleaning liquid is 1-12wt%, preferably 2-10wt%, 4-8wt%, more preferably 5-7wt%, and most preferably 6-7wt%; for example, it can be 2wt%, 3wt%, 4wt%, 5wt% or more, and 11wt%, 10wt%, 9wt%, 8wt%, 7wt% or less.

[0081] If the content of N-long chain acyl amino acid is greater than 12wt%, the composition will feel sticky when used, and if the content of N-long chain acyl amino acid is less than 1wt%, the cleaning power is insufficient. From the perspective of both cleaning power and washing feeling, the most suitable content of N-long chain acyl amino acid is 5-7wt%.

[0082] The weight percentage of the basic amino acid in the composition is 0.5-8wt%, preferably 1-6.5wt%, 2-5.5wt%, more preferably 3-5wt%; for example, it can be 1wt%, 1.5wt%, 2wt%, 2.5wt% or more, and 7wt%, 6wt%, 5wt%, 4wt% or less.

[0083] The N-long-chain acyl group in the N-long-chain acyl amino acid is derived from a saturated or unsaturated straight-chain or branched fatty acid having 8 to 22 carbon atoms. Further, the N-long-chain acyl group in the N-long-chain acyl amino acid is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, and palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, and most preferably lauroyl.

[0084] The amino acids in the N-long-chain acyl amino acids are derived from one or more of glycine, alanine, glutamic acid, sarcosine, aspartic acid, leucine, isoleucine, valine, threonine, proline, phenylalanine, arginine, and lysine. Further, the amino acids in the N-long-chain acyl amino acids are derived from one or more of alanine, glycine, glutamic acid, sarcosine, arginine, lysine, and (methyl) taurine, preferably alanine, and most preferably L-alanine.

[0085] The N-long-chain acyl (methyl) taurine described in the present invention refers to N-long-chain acyl methyl taurine or N-long-chain acyl taurine.

[0086] As an example, the N-long-chain acyl amino acid can be selected from cocoyl alanine, lauroyl alanine, cocoyl sarcosine, lauroyl sarcosine, lauroyl glutamic acid, cocoyl glutamic acid, oleoyl glutamic acid, cocoyl glycine, lauroyl glycine, stearoyl glutamic acid, etc., preferably lauroyl alanine and lauroyl sarcosine, and especially preferably N-lauroyl-L-alanine.

[0087] The synthesis process of N-long-chain acylamino acids can refer to the general synthesis method of N-acylamino acid type surfactants, which can be divided into direct method and indirect method. The direct synthesis method of fatty acid raw materials includes enzyme catalytic synthesis and dehydration condensation. The indirect synthesis method includes fatty acid chloride acylation, fatty nitrile hydrolysis acylation, fatty acid anhydride acylation, amide carbonylation reaction, etc. More preferably, it is prepared by the reaction of fatty acid chloride with the amino group of amino acid (Shotten-Baumann condensation reaction or Shotten-Baumann reaction).

[0088] A typical preparation process suitable for the present invention is as follows: amino acid and sodium hydroxide are dissolved in water or a mixed solution of water and acetone to obtain an amino acid salt solution; then lauroyl chloride and sodium hydroxide solution are slowly added dropwise to the amino acid salt solution to control the pH of the reaction system, and after the addition is completed, the product is post-treated. Representative methods are disclosed in CN1798821A, US6703517B2, CN102875409B, JPH0570418A, etc.

[0089] For the post-treatment of the N-long-chain acyl amino acid product, conventional recrystallization, water washing, drying, etc. can be used, or the methods disclosed in CN202210867760.7 and PCT / CN2022 / 107270 can be used. Here, the relevant contents are introduced together.

[0090] The basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, and diaminopropionic acid, preferably arginine and / or lysine, and most preferably arginine.

[0091] For component (a), the main surfactant can also be composed of N-long chain acyl amino acid, N-long chain acyl amino acid dipeptide and basic amino acid. The introduction of N-long chain acyl amino acid dipeptide can further improve the comprehensive performance of the cleaning solution.

[0092] The types and synthesis methods of N-long-chain acyl amino acids and basic amino acids have been described above. N-long-chain acyl amino acid dipeptide is a known concept, and long-chain acyl amino acid dipeptide refers to long-chain acylaminoacyl amino acids, typically long-chain acyl glycyl glycine, long-chain acyl glutamyl glutamic acid, long-chain acyl alanyl alanine, long-chain acyl sarcosyl sarcosine, etc., for example, see CN100448968C, PCT / CN2022 / 107270, etc.

[0093] N-long-chain acyl amino acid dipeptide can be prepared from acyl chloride derived from N-long-chain acyl amino acid and amino acid by Schotten-Bowman reaction, etc.; or by reacting amino acid dipeptide such as glutamylglutamic acid with acyl chloride. Preferably, it is obtained by the relevant preparation method disclosed in PCT / CN2022 / 107270, and the relevant content is introduced here.

[0094] The N-long-chain acyl group in the N-long-chain acyl amino acid dipeptide is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, and palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, and most preferably lauroyl;

[0095] The amino acid in the N-long-chain acyl amino acid dipeptide is derived from one or more of alanine, glycine, glutamic acid, sarcosine, arginine, lysine, (methyl) taurine, preferably L-alanine. The present invention preferably uses N-long-chain acyl-L-alanine dipeptide, especially N-lauroyl-L-alanyl-L-alanine.

[0096] The weight percentage of N-long chain acyl amino acid and N-long chain acyl amino acid dipeptide in the cleaning liquid is 1-12wt%, preferably 2-10wt%, 4-8wt%, more preferably 5-7wt%; for example, it can be 2wt%, 3wt%, 4wt%, 5wt% or more, 11wt%, 10wt%, 9wt%, 8wt%, 7wt% or less. The weight percentage of basic amino acid in the cleaning liquid is 0.5-8wt%, preferably 1-6.5wt%, 2-5.5wt%, more preferably 3-5wt%; for example, it can be 1wt%, 1.5wt%, 2wt%, 2.5wt% or more, 7wt%, 6wt%, 5wt%, 4wt% or less.

[0097] Furthermore, the weight percentage of the N-long-chain acyl amino acid dipeptide in the cleaning solution is above 0.1 wt %, preferably above 0.3 wt %, and more preferably above 0.5 wt %.

[0098] Further, the weight ratio of N-long chain acyl amino acid to N-long chain acyl amino acid dipeptide is 20: 1 to 1.5: 1, preferably 15: 1 to 3: 1, more preferably 10: 1 to 6: 1. The weight ratio of N-long chain acyl amino acid to N-long chain acyl amino acid dipeptide is, for example, 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, 7, 6, 5, 4, 3.

[0099] For component (a), further, for N-long-chain acyl amino acids / salts, when the amount of N-long-chain acyl glutamate is large, its foaming property is not satisfactory, and it imparts a sticky feeling, resulting in low rinsing properties. N-long-chain acyl glycinate has a more refreshing wash feeling than N-long-chain acyl glutamate, but N-long-chain acyl glycinate is easily precipitated in a weakly acidic to neutral system, resulting in an unstable system. The residue of N-long-chain acyl methyl taurine has a certain stickiness. Therefore, from the perspective of improving easy-to-rinse performance or water-saving performance, N-long-chain acyl amino acids are particularly preferably lauroyl alanine, because they have a very good wash feeling, are not sticky, and are stable under weakly acidic conditions.

[0100] For basic amino acids, especially arginine, they have a certain chelating effect on calcium and magnesium ions in water. When basic amino acids are combined with N-long-chain acyl amino acids as the main surfactant, the easy-to-rinse performance can be improved.

[0101] Most preferably, the main surfactant is selected to consist of lauroyl alanine and arginine, or the main surfactant is selected to consist of lauroyl alanine, lauroyl alanyl alanine and arginine.

[0102] For component (b), the co-surfactant comprises one or more of a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a sodium salt, a potassium salt, or a TEA salt of an N-long chain acylamino acid.

[0103] The weight percentage of the co-surfactant in the cleaning solution is 0-10wt%, for example, 0wt%, 1wt%, 2wt%, 3wt%, 4wt%, 5wt%, 6wt%, 7wt%, 8wt%, 9wt%; preferably 0-5wt%, more preferably 0-1wt%. It is not advisable to add too much co-surfactant, preferably add less or no co-surfactant, otherwise it will affect the mildness of the product to the skin / eyes, washing feeling, rinsing performance, etc.

[0104] Examples of nonionic surfactants include ester-type surfactants such as fatty acid glycerides, sorbitan fatty acid esters, and sucrose fatty acid esters, ether-type surfactants such as alkyl polyethylene glycols and polyoxyethylene alkylphenyl ethers, and nonionic surfactants such as alkyl polyglycosides. Nonionic surfactants have good emulsifying and solubilizing effects.

[0105] Examples of the cationic surfactant include alkyl quaternary ammonium salts, ester quaternary ammonium salts, alkyl pyridinium salts, alkyl amine salts and polymeric cationic surfactants. Cationic surfactants are often used in shampoos to increase the softness of hair.

[0106] As amphoteric surfactants, there can be cited: sulfobetaine amphoteric surfactants, betaine amphoteric surfactants, amphoteric acetate amphoteric surfactants, etc. For example, the amphoteric surfactant can be selected from one or more of cocamidopropyl betaine, lauroamidopropyl betaine, disodium cocoamphodiacetate, sodium cocamidoamphoacetate, sodium lauroamphoacetate, cocoyl betaine, lauryl hydroxysulfobetaine and lauroamidopropyl hydroxysulfobetaine. Amphoteric surfactants have good foaming, foam stabilizing and thickening effects.

[0107] The cleaning liquid of the present invention can be substantially free of nonionic surfactants, cationic surfactants, and amphoteric surfactants by selecting specific main surfactants, especially a combination of N-long-chain acyl amino acids (which may also contain dipeptides) and basic amino acids, and preferably completely free of nonionic surfactants, cationic surfactants, and amphoteric surfactants, so that the product can be made to have a more refreshing washing feeling, easy rinsing, and low irritation. This compounding method breaks the existing formula theory and achieves unexpected effects of refreshing washing feeling, easy rinsing, low irritation, and wash-free / dry-cleanable.

[0108] When N-long-chain acyl amino acids (optionally dipeptides) and basic amino acids are selected as the main surfactants, the sodium salts, potassium salts, and TEA salts of the corresponding N-long-chain acyl amino acids can be used as co-surfactants (wherein, the concept of N-long-chain acyl amino acids has been described above), which can take into account both performance and cost considerations. However, if cost is not considered, the surfactant is completely composed of N-long-chain acyl amino acids (which may also contain dipeptides) and basic amino acids without using any co-surfactants, which is the most preferred embodiment of the present invention.

[0109] Component (c) is not particularly limited. Specifically, ion exchange water, distilled water, purified water, river water, well water, natural water, groundwater, city water, hard water, soft water, etc. can be used. One of these can be used, or two or more selected from the above group can be mixed and used. From the viewpoint of storage stability and sanitation of the product of the present invention, ion exchange water, distilled water, purified water are preferred.

[0110] The cleaning solution of the present invention maintains low irritation while maintaining good cleaning power, and when arginine and N-long-chain acylamino acid are selected as the main surfactant, the product is also endowed with certain moisturizing properties. Therefore, it is very suitable for facial cleansing products.

[0111] In one embodiment, a makeup removal cleaning solution is provided. The cleaning solution comprises (a) a primary surfactant, (b) a co-surfactant, and (c) water. The details of components (a), (b), and (c) refer to the aforementioned embodiments and are not described in detail here.

[0112] In the process of makeup removal product development, the effect of makeup removal products can be judged by the residual amount after makeup removal. At the same time, in the makeup removal process, it is also necessary to reduce the irritation of makeup removal products during use, and it is necessary to be as gentle as possible. But often high makeup removal efficiency is opposed to low irritation and gentleness. For example, sodium lauroyl glutamate, potassium cocoyl glycinate, etc., although relatively gentle, have very weak ability to remove makeup and are difficult to be used as main surfactants in makeup removal products. The unexpected discovery of the present invention is that N-long-chain acyl amino acids (optional dipeptides) and basic amino acids are used as main surfactants, and the amount of surfactant used is limited to a reasonable range, so that the cleaning solution can take into account both low irritation and high makeup removal rate, which is very suitable for preparing a makeup removal solution with excellent performance.

[0113] In one embodiment, a shaving cleaning liquid is provided. The cleaning liquid comprises (a) a primary surfactant, (b) a co-surfactant, and (c) water. The details of components (a), (b), and (c) refer to the above embodiments and are not described in detail here.

[0114] In the development process of shaving products such as shaving foam and shaving cream, the products need to have rich and delicate foam, and at the same time, emollients and moisturizers need to be added to prevent discomfort during shaving. However, the formula obtained in this way is relatively greasy, and it is very easy to clog the razor and difficult to clean. The present invention surprisingly found that by using N-long-chain acylamino acids (optional dipeptides) and basic amino acids as the main surfactants and limiting the amount of surfactant to a reasonable range, a shaving cleaning liquid with rich foam, easy cleaning, and not easy to clog the blade can be obtained.

[0115] In one embodiment, a multifunctional cleaning liquid is provided. The cleaning liquid comprises (a) a primary surfactant, (b) a co-surfactant, and (c) water. The details of components (a), (b), and (c) refer to the above embodiments and are not described in detail here.

[0116] Cleansing, removing makeup, shaving, bathing, and shampooing are completely different product categories, and the formulation design concepts, raw material matching methods, etc. are very different. The present invention surprisingly found that by using N-long-chain acylamino acids (optional dipeptides) and basic amino acids as the main surfactants and limiting the amount of surfactants to a reasonable range, a "multi-effect in one" multifunctional cleaning solution can be prepared, which can meet the performance and index requirements of various functional fields.

[0117] In each of the above embodiments, the cleaning solution may further include component (d) preservative. The present invention unexpectedly found that benzoic acid has very good preservative properties in the system of the present invention, and its irritation is lower than other preservatives such as sodium benzoate, so benzoic acid is particularly preferred as the preservative. Generally speaking, sodium benzoate is often used in cosmetics because it has better water solubility, and in the system of the present invention, the combination of basic amino acids and N-long-chain acyl amino acids (optional dipeptides) can unexpectedly solubilize benzoic acid, making the use of benzoic acid in the system possible.

[0118] In each of the above embodiments, the cleaning solution may further contain component (e) spices or flavors. The present invention particularly prefers spices or flavors with good water solubility. When the main surfactant is a combination of N-long-chain acyl amino acids (optionally dipeptides) and basic amino acids, it is found that compared with the sodium salt and potassium salt of N-long-chain acyl amino acids, it has a more prominent solubilization effect on spices or flavors, and the solution is easier to be clear and transparent, especially when the cleaning solution does not contain polyols, which becomes very important.

[0119] In the above embodiments, the cleaning solution of the present invention may optionally further include other ingredients, such as dyes, chelating agents, extracts, amino acids, nucleic acids, vitamins, enzymes, anti-inflammatory agents, bactericides, antioxidants, ultraviolet absorbers, antiperspirants, pH adjusters, pearlescent agents, etc., but other ingredients cannot conflict with the safety and environmental protection, low irritation (skin / eyes), easy rinsing, refreshing washing feeling, oil control, etc. pursued by the present invention.

[0120] Thickener: Existing cleaning products often add thickeners to obtain liquids with a certain viscosity. Commonly used thickeners include cellulose, mucopolysaccharides, polyvinyl alcohols, colloids, sodium polyacrylates, polyvinyl pyrrolidones, vinyl polymers and other thickeners, such as common types of starch, gelatin, sodium alginate, guar gum, chitosan, gum arabic, xanthan gum, soy protein glue, polyacrylamide, polyvinyl alcohol, polyvinyl pyrrolidone, modified paraffin resin, carbo resin, styrene-butadiene rubber, etc. However, the addition of these thickeners will increase the skin irritation and eye irritation of the product, and destroy the refreshing washing feeling of the product. Sodium chloride is also commonly used for thickening, but more sodium chloride will irritate the scalp and eyes. Therefore, the cleaning solution of the present invention is preferably substantially free of thickeners and sodium chloride, and more preferably completely free of thickeners and sodium chloride.

[0121] Sulfate surfactants: Examples include sodium lauryl sulfate (SLS), ammonium lauryl sulfate (ALS), sodium laureth sulfate (SLES) or ammonium laureth sulfate (ALES). Considering that they may cause irritation to the skin or scalp and / or damage to hair fibers, the cleansing solution of the present invention preferably contains substantially no sulfate surfactants, more preferably contains no sulfate surfactants at all.

[0122] Ethoxylate: Typically, it is sodium laureth sulfate (SLES or AES). Considering that it is moderately irritating and that ethoxylated surfactants contain a large amount of non-renewable carbon from ethylene oxide, as well as safety issues (the dioxane impurities they contain are carcinogenic), the cleaning solution of the present invention is preferably substantially free of ethoxylates, and more preferably completely free of ethoxylates.

[0123] Fatty acid salts: laurate, myristate, palmitate, stearate are listed. Considering the tension, dryness and tightness after washing caused by such raw materials, the cleaning solution of the present invention preferably does not contain substantially any fatty acid salt, and more preferably does not contain any fatty acid salt at all.

[0124] Polyol moisturizers: Examples include glycerols such as glycerol, diglycerol, and polyglycerol, sugar alcohols such as sorbitol, erythritol, and xylitol, and glycols such as isopentyl glycol, 1,2-propylene glycol (PG), dipropylene glycol (DPG), ethoxydiglycol, and 1,3-butylene glycol (BG). The addition of polyols will bring a heavier sticky feeling. The cleaning solution of the present invention preferably does not contain substantially any polyol moisturizer, and more preferably does not contain any polyol moisturizer at all. Usually, cleaning products require the use of polyol moisturizers, but the present invention uses N-long-chain acyl amino acids (optional dipeptides) and basic amino acids as the main surfactants, which unexpectedly solves the problems of moisturizing and solubilization while exerting the cleaning effect.

[0125] In various embodiments, the cleaning liquid of the present invention is further low-viscosity. The low viscosity means that the viscosity at 25°C is less than 150 mPa·s, preferably less than 120 mPa·s, and more preferably less than 100 mPa·s. The lower limit of the viscosity is not particularly limited, and may be 1 mPa·s or more. The viscosity may be measured by conventional methods, for example, the composition at 25°C may be measured using a B-type viscometer.

[0126] In various embodiments, the cleaning liquid of the present invention further exhibits the performance of selective decontamination, that is, according to QB / T1224-2012 liquid detergent for clothing, JB-01 and JB-02 have higher values, while JB-03 has lower values. Further, JB-01 is above 0.8, preferably above 0.81, 0.82, 0.83, 0.84, 0.85, 0.86, 0.87, 0.88, 0.89 or 0.9; JB-02 is above 0.8, preferably above 0.81, 0.82, 0.83, 0.84, 0.85, 0.86, 0.87, 0.88, 0.89 or 0.9; JB-03 is above 0.4 The molecular weight of the present invention is 0.54, 0.62, 0.64, 0.66, 0.67, 0.68, 0.69, 0.70, 0.71, 0.72, 0.73, 0.74, 0.76, 0.77, 0.78, 0.79, 0.71, 0.70, 0.71, 0.71, 0.72, 0.73, 0.74, 0.76, 0.77, 0.78, 0.79, 0.71, 0.72, 0.71, 0.70, 0.71, 0.72, 0.73, 0.74, 0.76, 0.76, 0.77, 0.78, 0.79, 0.71, 0.72, 0.71, 0.70 ...

[0127] Compared with traditional petroleum-based surfactants such as AES, which show too high human skin oil cleaning (JB-03 reaches 1.4), it will damage the skin's protective barrier, cause excessive loss of sebum, and easily invade or irritate harmful substances, resulting in dryness, tightness, stinging, and even skin sensitivity after washing. The cleaning solution of the present invention can not only selectively remove dirt, but also will not excessively wash away "squalene" and triglycerides that protect the skin, protecting the skin's moisture barrier (JB-01 and JB-02 exceed 0.8 or even 0.9, but JB-03 maintains at around 0.5).

[0128] In the above embodiments, the cleaning solution of the present invention further exhibits unexpectedly excellent resistance to hard water. Further, according to the test standard: GB / T7462-1994 "Determination of Foaming Power of Surfactants - Improved Ross-Miles Method", the test instrument: 2152 Improved Ross Foam Tester, the foam performance of the composition in hard water is better than that in soft water. Preferably, under hard water conditions, the foam volume of 30s, 3min, and 5min is more than 400ml.

[0129] Most preferably, the main surfactant is selected to be composed of lauroyl alanine (optional dipeptide) and arginine, the weight percentage of lauroyl alanine in the cleaning solution is 1-12wt%, preferably 4-8wt%, more preferably 5-7wt%, and the weight percentage of basic amino acid in the cleaning solution is 0.5-8wt%, preferably 2-5.5wt%, more preferably 3-5wt%. At this time, under hard water conditions, the foam volume of 30s, 3min, and 5min exceeds 450ml, more preferably exceeds 460, 470, 480, 490 or 500ml.

[0130] In each embodiment, if there is no conflict in the content, detailed circumstances, type selection, dosage selection, etc. that are not discussed, reference can be made to the relevant guidance of other embodiments. For the sake of brevity, each embodiment is not described one by one.

[0131] The term "substantially free" in the present invention means that the content of the substance in the cleaning liquid will not significantly and substantially affect the performance of the product. Further, "substantially free" means that the weight percentage of the substance in the cleaning liquid is less than 0.5wt%, preferably less than 0.1wt% or less than 0.01wt%, and more preferably less than the detectable limit.

[0132] Unless otherwise specified, "above", "below" and "A to B" in the present invention all include the number. The dosage refers to the dosage of a specific substance, not the dosage of its corresponding solution (if any).

[0133] The combination of N-long-chain acyl amino acid (optional dipeptide) and basic amino acid described in the present invention means that the main surfactant consists of N-long-chain acyl amino acid and basic amino acid or the main surfactant consists of N-long-chain acyl amino acid, N-long-chain acyl amino acid dipeptide and basic amino acid.

[0134] The present invention will be further described below in conjunction with the accompanying drawings and examples, and it should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the content taught by the present invention, those skilled in the art may make various changes or modifications to the present invention, and these equivalents also fall within the scope limited by the appended claims of the present application.

[0135] The present invention will be further described below with reference to specific embodiments.

[0136] Example 1 Skin irritation test .

[0137] Test basis: Human skin irritation: Reconstructed human epidermis test method OECD TG 439 (2021).

[0138] Table 1

[0139]

[0140]

[0141] 1. Negative control is DPBS solution.

[0142] 2. The positive control is 5% SDS.

[0143] 3. The salt prepared by reacting lauroyl alanine with sodium hydroxide in a molar ratio of 1:1.

[0144] 4. The salt prepared by reacting lauroyl alanine with arginine in a molar ratio of 1:1.

[0145] According to the data in Table 1, it can be found that the surfactants based on N-long-chain acyl amino acids (lauroyl alanine) have significantly reduced skin irritation, especially the combination of N-long-chain acyl amino acids and basic amino acids (lauroyl alanine and arginine), which has almost no irritation to the human epidermis. However, traditional surfactants such as AES and K12 are obviously more irritating, and their addition will have an adverse effect on the mildness and low irritation of the end product.

[0146] Therefore, for products that come into contact with the skin, such as facial cleansing products, shaving cleansing products, and makeup removing cleansing products, it is more appropriate to use surfactants based on lauroyl alanine, and a combination of lauroyl alanine and arginine is particularly preferred.

[0147] Example 2 Eye irritation test .

[0148] Test basis: Bovine corneal opacity and permeability test OECD TG 437 (2020).

[0149] Table 2

[0150]

[0151]

[0152] 1. It is composed of lauroyl alanine, sodium hydroxide and water, and the composition contains 10% (w / v) of lauroyl alanine sodium salt.

[0153] 2. Composed of lauroyl alanine, arginine and water, the composition contains 10% (w / v) lauroyl alanine arginine salt.

[0154] 3. Take 1g AES (70% content), add water to make up to 10ml, and dilute to 10% (w / v).

[0155] 4. Take 1g K12, add water to make up to 10ml, dilute to 10% (w / v).

[0156] According to the data in Table 2, it can be found that the surfactants compounded with N-long-chain acyl amino acids and basic amino acids (compounded with lauroyl alanine and arginine) have the lowest irritation to the eyes. However, traditional surfactants such as AES and K12 and the sodium salt of N-long-chain acyl amino acids (sodium salt of lauroyl alanine) are relatively irritating to the eyes.

[0157] During the process of cleansing and makeup removal, it is difficult to avoid a small amount of cleansing liquid entering the eyes. The combination of N-long-chain acyl amino acids and basic amino acids shows unexpectedly low irritation to the eyes.

[0158] Example 3 Cleaning power test .

[0159] Test basis: QB / T 1224-2012 Test for liquid detergents for clothing. The following contents refer to percentage by weight.

[0160] JB-01 involves artificial simulation of mixed oil stains, mainly verifying the cleaning power against oil and dust stains; JB-02 involves multiple protein stains, mainly verifying the cleaning power against protein stains; JB-03 involves artificial simulation of sebum stains, mainly verifying the cleaning power against human body oil stains.

[0161] Table 3

[0162]

[0163]

[0164] According to the data in Table 3, it can be found that whether lauroyl alanine is compounded with an inorganic base (sodium hydroxide in the embodiment) or with a basic amino acid (arginine in the embodiment), the values ​​of JB-01 and JB-02 are both high, indicating that the removal ability of oil, dust stains, and protein stains is strong, and the value of JB-03 is moderate, indicating that the removal ability of human sebum stains is moderate, reflecting obvious selective decontamination ability. This is crucial to not excessively wash away the "squalene" and triglycerides that protect the skin and protect the skin's moisture barrier.

[0165] In addition, the data also show that lauroyl alanine-arginine-based surfactants have excellent cleaning power for oil, dust stains, and protein stains, which is significantly stronger than common mild surfactants such as glutamate and sophorolipids, making it possible to use lauroyl alanine-arginine as the main surfactant.

[0166] Example 4 Makeup removal test .

[0167] Test reagents: ① sodium lauroyl glutamate aqueous solution, ② potassium cocoyl glycinate aqueous solution, ③ sodium lauroyl sarcosinate aqueous solution, ④ lauroyl alanine arginine aqueous solution.

[0168] Test plan: Prepare a standard aqueous solution by mixing 4 commercially available amino acid surfactant solutions with water at a ratio of 1:20. Weigh 2g of each sample and apply it to the skin that has been smeared with lipstick. After wetting, wipe with hands to observe the makeup removal ability.

[0169] The solid content of commercially available sodium lauroyl glutamate solution, potassium cocoyl glycinate solution, and sodium lauroyl sarcosinate solution is about 30%-35%. The lauroyl alanine arginine solution is LA-Arg 30 (containing 20% ​​lauroyl alanine + 12.8% arginine) produced by Suzhou Weimei Biotechnology Co., Ltd.

[0170] Figure 1 and Figure 2 The figure shows the effect of removing lipstick by wiping with hands after wetting. As can be seen from the figure, the makeup removal ability from strong to weak is: ④ lauroyl alanine arginine aqueous solution > ② cocoyl glycinate potassium aqueous solution > ③ lauroyl sarcosinate sodium aqueous solution > ① lauroyl glutamate sodium aqueous solution.

[0171] From this test, it can be seen that the surfactant based on lauroyl alanine-arginine has a higher cleaning power than the traditional amino acid surfactant. Combined with Examples 3 and 4, it is verified for the first time that the lauroyl alanine-arginine compound can be used as the main surfactant.

[0172] Therefore, surfactants based on lauroyl alanine-arginine can simultaneously take into account mildness, low irritation and high cleaning power, making it possible to use it as the main surfactant or even the only surfactant in products such as cleansing, makeup removal, bathing, and shampooing.

[0173] Example 5 Foam test .

[0174] Test standard: GB / T7462-1994 "Determination of foaming power of surfactants - Improved Ross-Miles method".

[0175] Test instrument: Model 2152 Improved Roche Foam Tester.

[0176] Test method: According to the test standard GB / T7462-1994, test the foaming power of the samples and compare the differences in their foam performance.

[0177] Test conditions: Test solution concentration: 2.5g / L; Test temperature: 50±0.5℃; Test water: soft water / hard water.

[0178] Reagents: DCG30: Sodium Cocoyl Glutamate, ACS30: Sodium Cocoyl Alanine, GC30: Sodium Cocoyl Glycinate, GCK30: Potassium Cocoyl Glycinate, SCMT-35: Sodium Cocoyl Methyl Taurate, AES: Sodium Laureth Sulfate.

[0179] Table 4

[0180]

[0181]

[0182] The test results are shown in Table 4 and Figure 3 It can be seen that lauroyl alanine-arginine has better foaming performance in hard water than in soft water, indicating that it has the characteristics of resistance to hard water. Considering that most areas in China have hard water, lauroyl alanine-arginine is very suitable as the main surfactant of cleaning liquid. Under hard water conditions, its foaming performance is even better than AES.

[0183] Example 6 Deodorizing performance .

[0184] Test equipment: drum washing machine (XQB80-Z1708), electronic balance (PL2002), pipette (5mL).

[0185] Test materials and reagents:

[0186] JB-00 cotton white cloth (GB / T 13174, 25cm25cm); artificial sweat (QB / T1901.2-93); pure cotton T-shirt; yellow croaker.

[0187] Test process

[0188] Fishy odor removal test: Put the chilled yellow croaker into a sealed bag and add 30mL of tap water, and leave it at room temperature for 4 hours. Find 5 testers and wash their hands with clean water to ensure that there is no odor. Take the water in the sealed bag and drop 5mL in the palm of each tester. The tester evenly applies the fishy odor water to the backs and palms of both hands, waits for 5 minutes, takes 2mL of the sample solution to be tested, simulates washing hands with hand sanitizer for 2 minutes, rinses with tap water and wipes the water off the hands, and the tester feels whether there is still odor on the hands.

[0189] Sweat odor removal test: Take a piece of JB-00 cotton white cloth, evenly add 2mL of artificial sweat, and then put it in a sealed bag for 4 hours. Select the common washing mode of the washing machine, select 30L of water, rinse twice, dehydrate for 5 minutes, put in 3 pure cotton T-shirts and sweat-stained cotton white cloth, add 60g of the sample solution to be tested, start the washing machine for washing, and take out the pure cotton T-shirts and cotton white cloth to dry after washing. Find 5 evaluation personnel to feel whether there is still odor on the cotton white cloth.

[0190] The results were evaluated according to the following criteria:

[0191] 0 points – no odor residue;

[0192] 1 point: slight odor remains;

[0193] 2 points: There is a noticeable odor residue.

[0194] Table 5

[0195]

[0196] 1# Lauroyl Sarcosinate 6% + Benzoic Acid 0.4% + Essence 0.25% + Remainder Water (TO 100)

[0197] 2# Lauroyl Alanine 6% + Arginine 3.84% + Benzoic Acid 0.2% + Essence 0.25% + Balance Water (TO 100)

[0198] 3# Lauroyl Alanine 6% + Arginine 3.45% + Benzoic Acid 0.2% + Essence 0.25% + Remaining Water (TO 100)

[0199] According to the evaluation data in Table 5, it can be known that when lauroyl alanine and basic amino acids are compounded in a molar ratio of 1:0.9, the best deodorizing performance is achieved.

[0200] Example 7 Easy rinse performance .

[0201] Test materials and reagents:

[0202] a) each sample solution to be tested;

[0203] b) Artificial dirt, prepared according to B2.4 of GB / T 9985-2000;

[0204] c) anhydrous calcium chloride, AR.;

[0205] d) Magnesium chloride (MgCl2·6H2O), AR.;

[0206] e) Deionized water.

[0207] Instruments and equipment:

[0208] a) Electronic balance, accuracy 0.01g;

[0209] b) 2 white porcelain dish plates, outer diameter about 250mm;

[0210] c) Washbasin, volume 6L;

[0211] d) Graduated cylinder, 1000 mL;

[0212] e) Bottom-mouth bottle (see GB / T 9985), 5000 mL;

[0213] f) Pig brown paint brush, 102mm.

[0214] Test process:

[0215] a) According to the operation of B2.5 of GB / T 9985-2000, prepare two plates coated with artificial dirt. The amount of dirt on each test plate is 4g. After coating, place them at room temperature overnight for use;

[0216] b) Wash the two test plates cleanly according to the washing procedure in B2.6 of GB / T 9985-2000 (using each sample solution as the test sample);

[0217] c) Pour 1000 mL of deionized water into the lower-mouthed bottle (the lower part of the outlet tube of the lower-mouthed bottle is pre-filled with deionized water and excess water is released until no more water can be released), open the outlet tube and rinse the dishes washed in step (b) with 1000 mL of deionized water, and collect the rinse liquid.

[0218] d) Repeat step (c) for each test disk to prepare the second rinse solution and the third rinse solution.

[0219] Results evaluation:

[0220] By testing the pH of the resulting rinse solution, the residual condition of the test sample can be determined, and the easy-rinsing performance of the product can be determined based on the result.

[0221] Table 6

[0222]

[0223] 1# Lauroyl Sarcosinate 6% + Benzoic Acid 0.4% + Essence 0.25% + Remainder Water (TO 100)

[0224] 2# Lauroyl Alanine 6% + Arginine 3.84% + Benzoic Acid 0.2% + Alkyl Glucoside 1% + Cocamidopropyl Betaine 4.5% + Glycerin 5% + Essence 0.25% + Remainder Water (TO 100)

[0225] 3# Sodium Cocoyl Glutamate 6% + Benzoic Acid 0.4% + Essence 0.25% + Remaining Water (TO 100)

[0226] 4# Lauroyl Alanine 6% + Arginine 3.84% + Benzoic Acid 0.2% + Essence 0.25% + Balance Water (TO 100)

[0227] Example 8 Washing feeling, irritation .

[0228] Find 5 reviewers to conduct the evaluation. Washing feeling (apply each sample to be tested directly to the arm / face, dry clean / no wash): non-sticky 0, slightly sticky 1, moderately sticky 2, and severely sticky 3.

[0229] Find 5 evaluators to conduct the evaluation. Irritation (apply each sample to be tested directly to the arm / face, dry clean / no wash): mild and non-irritating 0, mild irritation 1, moderate irritation 2, severe irritation 3.

[0230] Table 7

[0231]

[0232]

[0233] 1# Lauroyl Sarcosinate 6% + Benzoic Acid 0.4% + Essence 0.25% + Remainder Water (TO 100)

[0234] 2# Lauroyl Alanine 6% + NaOH 0.87% + Benzoic Acid 0.4% + Essence 0.25% + Balance Water (TO 100)

[0235] 3# Lauroyl Alanine 6% + Arginine 3.84% + Benzoic Acid 0.2% + Alkyl Glucoside 1% + Cocamidopropyl Betaine 4.5% + Glycerin 5% + Essence 0.25% + Remainder Water (TO 100)

[0236] 4# Lauroyl Alanine 6% + Arginine 3.84% + Benzoic Acid 0.2% + Alkyl Glucoside 2% + Essence 0.25% + Balance Water (TO 100)

[0237] 5# Lauroyl Alanine 6% + Arginine 3.84% + Benzoic Acid 0.2% + Cocamidopropyl Betaine 6% + Essence 0.25% + Balance Water (TO 100)

[0238] 6# Lauroyl Alanine 6% + Arginine 3.84% + Benzoic Acid 0.2% + Glycerin 10% + Essence 0.25% + Remaining Water (TO 100)

[0239] 7# Sodium Cocoyl Glutamate 6% + Benzoic Acid 0.4% + Essence 0.25% + Remaining Water (TO 100)

[0240] 8# Lauroyl Alanine 6% + Arginine 3.84% + Benzoic Acid 0.2% + Essence 0.25% + Balance Water (TO 100)

[0241] Example 9 Cleansing solution patch test .

[0242] Table 8

[0243] raw material Dosage (W%) A water 89.71 B Lauroyl Alanine 6 C Arginine 3.84 D benzoic acid 0.2 E essence 0.25

[0244] Heat and dissolve raw materials A, B, and C at 80-85°C, and stir until they are completely dissolved and transparent; then cool to below 45°C, add D and E, and stir until they are completely dissolved and uniform; take samples, and filter out the material after passing the test.

[0245] A human skin patch test was conducted on the above cleaning solutions.

[0246] 1. Test basis: SOP502-01CL- Single human skin patch test

[0247] 2. Materials and Methods

[0248] 2.1 Test article: Test as is.

[0249] 2.2 Negative control: Use grade 3 water in GB / T 6682.

[0250] 2.3 Subjects: A total of 30 subjects, 4 males and 26 females, aged 22 to 54 years old.

[0251] 2.4 Method: Select qualified patch test equipment and use the closed patch test method. Place about 0.02 mL of the test substance in the patch tester and apply it to the upper back of the subject with a hypoallergenic tape. Remove the test substance after 48 hours and observe the skin reaction 30 minutes after removal. Record the results according to the skin reaction grading standard in the "Safety Technical Specifications for Cosmetics" (2015 edition).

[0252] 3. Subject inclusion criteria

[0253] 3.1 Select volunteers aged 18-60 who meet the test requirements as subjects.

[0254] 4. Test Results

[0255] Table 9

[0256]

[0257] Note: The skin reactions of 30 subjects to a single 48-hour patch are shown in Table 10.

[0258] The results of the 48-hour irritation patch test showed that in a single 48-hour patch test, 0 of the 30 people had adverse skin reactions, indicating that the cleaning solution of the present invention can be washed without water, and even if the cleaning solution stays on the skin for 48 hours, no adverse skin reactions will occur.

[0259] Table 10 Skin reactions of 30 subjects in a single human skin patch test

[0260]

[0261]

[0262]

[0263] Furthermore, a limit test was conducted, and the operation in Section 2.4 was repeated 3 times (i.e., 48 h × 3) according to SOP502-01CL-Multiple Human Skin Patch Test, and the results are recorded in Table 11. Among them, test substance 1 was obtained according to the formulation and preparation method of Table 8; test substance 2 was obtained according to the formulation and preparation method of Table 8, except that the preservative benzoic acid was replaced with sodium benzoate.

[0264] Table 11

[0265]

[0266] The results of the 48h×3 irritation patch test showed that because the preservative of Test 2 was replaced with sodium benzoate, the number of people with skin reactions reached 9 after 3 cycles of patch tests. Compared with Test 1 using benzoic acid, the number of people with skin reactions was 5, a difference of nearly 1 times. This shows that the use of benzoic acid as a preservative has significantly reduced skin irritation.

[0267] Example 10 Facial cleansing liquid (basic formula, minimalist formula) .

[0268] Table 12

[0269]

[0270]

[0271] Heat and dissolve raw materials A, B, and C at 80-85°C, and stir until they are completely dissolved and transparent; then cool to below 45°C, add D, and stir until it is completely dissolved and uniform; take samples, and filter out the material after passing the test.

[0272] This cleansing liquid basic formula has rich and dense foam (see Figure 4 ), it does not make your face feel tight after washing, it can effectively remove dirt on your face while being gentle and non-irritating.

[0273] Embodiment 11 Makeup remover (basic formula, minimalist formula) .

[0274] Table 13

[0275] raw material Dosage (W%) A water 89 B Lauroyl Alanine 6.6 C Arginine 4.2 D benzoic acid 0.2

[0276] Heat and dissolve raw materials A, B, and C at 80-85°C, and stir until they are completely dissolved and transparent; then cool to below 45°C, add D, and stir until it is completely dissolved and uniform; take samples, and filter out the material after passing the test.

[0277] The basic formula of this makeup remover can effectively remove conventional makeup such as lipstick, eyebrow powder, blush, eye shadow, etc. (see Figure 5 ).

[0278] Example 12 Shaving cleanser (basic formula, minimal formula) .

[0279] Table 14

[0280] raw material Dosage (W%) A water 89 B Lauroyl Alanine 6.6 C Arginine 4.2 D benzoic acid 0.2

[0281] Heat and dissolve raw materials A, B, and C at 80-85°C, and stir until they are completely dissolved and transparent; then cool to below 45°C, add D, and stir until it is completely dissolved and uniform; take samples, and filter out the material after passing the test.

[0282] Ingredients of a commercially available shaving cleanser: water, cetearyl alcohol, glyceryl stearate, cetrimonium chloride, fragrance, propylene glycol, benzyl alcohol, and methylisothiazolinone.

[0283] Two razors of the same brand and model were used to shave with the shaving cleansing liquid of Example 12 and a commercially available shaving cleansing liquid, respectively. After shaving, the razors were placed under the same conditions for 48 hours. Figure 6 As shown, the commercially available shaving cleaning liquid is very easy to stick to the razor, and if you forget to deal with it in time, it is very difficult to clean it. However, the shaving cleaning liquid of Example 12 is not easy to stick to the cutter head even if you forget to rinse it after use.

[0284] In addition, those skilled in the art will appreciate that, although some embodiments described herein include certain features included in other embodiments but not other features, the combination of features of different embodiments is meant to be within the scope of the present invention and form different embodiments. For example, in the claims below, any one of the claimed embodiments may be used in any combination.

Claims

1. A facial cleansing liquid, characterized in that: Comprising (a) a main surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the main surfactant in all surfactants exceeds 50wt%, preferably exceeds 65wt%, and more preferably exceeds 80wt%; The main surfactant is composed of N-long chain acyl amino acid and basic amino acid; or, the main surfactant is composed of N-long chain acyl amino acid, N-long chain acyl amino acid dipeptide and basic amino acid.

2. A makeup removing cleaning solution, characterized in that: Comprising (a) a main surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the main surfactant in all surfactants exceeds 50wt%, preferably exceeds 65wt%, and more preferably exceeds 80wt%; The main surfactant is composed of N-long chain acyl amino acid and basic amino acid; or, the main surfactant is composed of N-long chain acyl amino acid, N-long chain acyl amino acid dipeptide and basic amino acid.

3. A shaving cleansing liquid, characterized in that: Comprising (a) a main surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the main surfactant in all surfactants exceeds 50wt%, preferably exceeds 65wt%, and more preferably exceeds 80wt%; The main surfactant is composed of N-long chain acyl amino acid and basic amino acid; or, the main surfactant is composed of N-long chain acyl amino acid, N-long chain acyl amino acid dipeptide and basic amino acid.

4. A multifunctional cleaning liquid, characterized in that: Comprising (a) a main surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the main surfactant in all surfactants exceeds 50wt%, preferably exceeds 65wt%, and more preferably exceeds 80wt%; The main surfactant is composed of N-long chain acyl amino acid and basic amino acid; or, the main surfactant is composed of N-long chain acyl amino acid, N-long chain acyl amino acid dipeptide and basic amino acid.

5. The cleaning liquid according to any one of claims 1 to 4, characterized in that When the main surfactant is composed of N-long-chain acyl amino acids and basic amino acids, the weight percentage of N-long-chain acyl amino acids in the cleaning solution is 1-12wt%, preferably 4-8wt%, more preferably 5-7wt%, and the weight percentage of basic amino acids in the cleaning solution is 0.5-8wt%, preferably 2-5.5wt%, more preferably 3-5wt%; or, when the main surfactant is composed of N-long-chain acyl amino acids, N-long-chain acyl amino acid dipeptides and basic amino acids, the total weight percentage of N-long-chain acyl amino acids and N-long-chain acyl amino acid dipeptides in the cleaning solution is 1-12wt%, preferably 4-8wt%, more preferably 5-7wt%, and the weight percentage of basic amino acids in the cleaning solution is 0.5-8wt%, preferably 2-5.5wt%, more preferably 3-5wt%; The weight percentage of the co-surfactant in the cleaning solution is 0-10wt%, preferably 0-5wt%, more preferably 0-1wt%.

6. The cleaning liquid according to any one of claims 1 to 4, characterized in that: The cleaning solution is substantially free of thickeners, preferably completely free of thickeners; and / or, substantially free of sodium chloride, preferably completely free of sodium chloride; and / or, substantially free of sulfates, preferably completely free of sulfates; and / or, substantially free of ethoxylates, preferably completely free of ethoxylates; and / or, substantially free of fatty acid salts, preferably completely free of fatty acid salts; And / or, substantially no polyol humectant is contained, preferably no polyol humectant is contained.

7. The cleaning liquid according to any one of claims 1 to 4, characterized in that: The N-long-chain acyl group in the N-long-chain acyl amino acid is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, and palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, and most preferably lauroyl; And / or, the amino acid in the N-long-chain acylamino acid is derived from one or more of alanine, glycine, glutamic acid, sarcosine, arginine, lysine, (methyl)taurine, preferably alanine, most preferably L-alanine.

8. The cleaning liquid according to any one of claims 1 to 4, characterized in that: The basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, and diaminopropionic acid, preferably arginine and / or lysine, and most preferably arginine.

9. The cleaning solution according to any one of claims 1 to 4, characterized in that The invention further comprises (d) a preservative, wherein the preservative is benzoic acid.

10. The cleaning liquid according to any one of claims 1 to 4, characterized in that: The pH of the cleaning solution is 5 to 7.5, preferably 5.5 to 6.9, more preferably 6 to 6.5; And / or, the cleaning liquid has a low viscosity, wherein the low viscosity means that the viscosity at 25° C. is lower than 150 mPa·s, preferably lower than 120 mPa·s, and more preferably lower than 100 mPa·s.

11. The cleaning liquid according to any one of claims 1 to 4, characterized in that: The specified cloth detergency of the cleaning liquid is tested in accordance with QB / T1224-2012 Liquid Detergents for Clothes: JB-01 is above 0.8; and / or, JB-02 is above 0.8; and / or, JB-03 is above 0.4 and below 0.

8.

12. The cleaning liquid according to any one of claims 1 to 4, characterized in that: The foam performance of the cleaning liquid in hard water is better than that in soft water; and / or, under hard water conditions, the foam volume in 30s, 3min, and 5min exceeds 400ml, preferably exceeds 450ml, and more preferably exceeds 500ml; the aforementioned test standard: GB / T7462-1994 "Determination of Foaming Power of Surfactants - Improved Ross-Miles Method", test instrument: 2152 Improved Ross Foam Tester.

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