Medicinal and edible composition for treating vitiligo as well as preparation and application of medicinal and edible composition

Abstract

The invention provides a medicinal and edible composition for treating vitiligo as well as a preparation and application thereof, and the medicinal and edible composition comprises the following components in parts by weight: 1-8 parts of peach kernel, 1-8 parts of galangal, 1-8 parts of angelica dahurica and 1-8 parts of black sesame. According to the invention, the peach kernel, the galangal, the radix angelicae and the black sesame which are homologous in medicine and food are combined, so that the effect of treating leucoderma is exerted. Animal experiments show that the effective rate of the peach kernel, galangal, angelica dahurica and black sesame medicine composition for treating vitiligo can reach 70%, the content of tyrosinase in serum of vitiligo model guinea pigs can be increased, synthesis of melanin is accelerated, meanwhile, the content of alpha-melanin cell stimulant in serum of the vitiligo model guinea pigs can be increased, and the curative effect is good. The generation of skin melanin is promoted, and melanin cells are protected.

Description

Technical Field

[0001] The present invention relates to the field of pharmaceutical technology, and in particular to a medicine-food dual-purpose composition for treating vitiligo, and a preparation and application thereof. Background Art

[0002] Vitiligo is a localized or generalized skin depigmentation disease caused by the decline of melanocyte function in the skin. It is common in the face, neck, genitals, forearms, wrists, back of hands and other parts. Most patients have no obvious symptoms. A few patients have local itching in the affected area before the onset of the disease. It is often accompanied by autoimmune diseases such as diabetes, adrenal insufficiency, atopic dermatitis, and thyroid disease. The pathogenesis of this disease is complex and has not yet been fully elucidated, and there is no ideal means for treatment. Western medicine treatment is mostly ultraviolet irradiation and surgical operation. The drugs include corticosteroids, immune preparations, vitamins, copper-containing drugs, etc. However, Western medicine has large side effects and low patient compliance. Ultraviolet irradiation has a certain effect, but it is expensive. Surgical treatment has indications and cannot guarantee that the disease will not recur.

[0003] Traditional Chinese medicine calls vitiligo "white spots" and "white spots". Traditional Chinese medicine believes that vitiligo is mainly caused by long-term emotional trauma, exogenous wind evil and dampness, which lead to poor body qi, liver qi stagnation, kidney essence deficiency, and qi and blood disorder, thus causing vitiligo symptoms. Traditional Chinese medicine divides vitiligo into eight types: rheumatism and heat accumulation type, liver qi stagnation type, liver and kidney deficiency type, qi stagnation and blood stasis type, heart and kidney disharmony type, qi and blood deficiency type, spleen and stomach weakness type, and blood heat and wind dryness type. Through the treatment principles of syndrome differentiation and holistic concept, different Chinese medicine treatments are adopted for different symptoms. The treatment principles are clearing away heat and dampness, promoting qi and blood circulation, soothing the liver and relieving depression, soothing wind and cold, nourishing the liver and kidney, nourishing blood and removing wind, promoting blood circulation and removing blood stasis, nourishing qi and blood, promoting qi and unblocking collaterals, nourishing qi and nourishing blood, harmonizing the spleen and stomach, and nourishing yin and blood. Treatment uses Chinese herbal decoctions, pills, powders, and ointments, while acupuncture is used to relax the meridians and dredge the collaterals, promote qi and blood circulation, and replenish the deficiency and eliminate the excess. It is quick in effect, has no toxic side effects, and has significant clinical efficacy.

[0004] Vitiligo is a localized or generalized skin depigmentation disease caused by the functional decline of skin melanocytes. Currently, there are no reports on the combined use of peach kernel, galangal, angelica dahurica, and black sesame to treat vitiligo. Summary of the invention

[0005] In view of this, the purpose of the present invention is to propose a medicine-food composition for treating vitiligo and its preparation and application, and to propose the use of peach kernel, galangal, angelica dahurica and black sesame, which are both medicine and food, in combination for treating vitiligo, so as to obtain a medicine-food composition with high stability, good effect in treating vitiligo and safe use.

[0006] The technical solution of the present invention is achieved in this way:

[0007] A medicine and food dual-purpose composition for treating vitiligo comprises the following components by weight: 1-8 parts of peach kernel, 1-8 parts of galangal, 1-8 parts of angelica dahurica and 1-8 parts of sesame.

[0008] Furthermore, the following components are included by weight: 2 to 6 parts of peach kernels, 1 to 3 parts of galangal, 1 to 3 parts of angelica dahurica and 2 to 6 parts of sesame.

[0009] Furthermore, the peach kernel is peach kernel powder, and the preparation method of the peach kernel powder includes crushing the peach kernel, adding water for water extraction, filtering, concentrating the filtrate, spray drying, and obtaining the peach kernel powder; the mass ratio of the peach kernel powder to water is 1:8-15, and the water extraction is performed 1-3 times, each time for 1-3 hours.

[0010] Furthermore, the galangal is galangal powder. The preparation method of the galangal powder includes crushing the galangal, adding ethanol for reflux extraction, concentrating, and spray drying to obtain the galangal powder; the mass ratio of the galangal powder to the ethanol is 1:4-7, the volume concentration of the ethanol is 50%-70%, the reflux extraction is performed 1-3 times, each extraction is 1-3 hours, and the concentration is performed to a relative density of 1.1-1.2.

[0011] Furthermore, the angelica dahurica is angelica dahurica powder, and the preparation method of the angelica dahurica powder includes crushing the angelica dahurica, adding water for water extraction, filtering, concentrating the filtrate, spray drying, and obtaining the angelica dahurica powder; the mass ratio of the angelica dahurica powder to water is 1:8-15, and the water extraction is performed 1-3 times, each time for 1-3 hours.

[0012] Furthermore, the sesame is black sesame powder, and the preparation method of black sesame powder includes taking black sesame, squeezing out oil, taking the residue for low-temperature drying, and crushing to 90-110 mesh to obtain black sesame powder; the pressing temperature is 35-55°C, the time is 2-5h, and the low-temperature drying temperature is 25-35°C, and the time is 0.5-5h.

[0013] The present invention provides a preparation for treating vitiligo, wherein the medicine-food dual-purpose composition and medically acceptable adjuvants are used to prepare the preparation; the dosage form of the preparation includes powder, granules, pills, tablets, suspension or oral solution.

[0014] The present invention also provides an application of the above preparation in treating vitiligo.

[0015] Furthermore, the vitiligo is vitiligo of qi stagnation and blood stasis syndrome.

[0016] Peach kernel is the dried mature seed of Prunus persica (L.) Batsch or Prunus davidiana (Carr.) Franch. of the Rosaceae family. It is a commonly used medicinal and edible material with the effects of promoting blood circulation and removing blood stasis, moistening the intestines and relieving constipation, and relieving cough and asthma. It is used for amenorrhea, dysmenorrhea, abdominal masses, lung and intestinal abscesses, traumatic injuries, dry intestines and constipation, and cough and asthma.

[0017] Alpinia officinarum Hance is a dried rhizome of Alpinia officinarum Hance, a plant of the ginger family. It is a common medicinal and edible material with the effects of warming the middle and dispelling cold, regulating qi and relieving pain. It is used for cold pain in the abdomen, vomiting, and belching. It mainly contains diphenylheptanes, flavonoids, volatile oils and other compounds. The pharmacological effects are antibacterial, delaying thrombosis time, inhibiting coagulation, and analgesia.

[0018] Angelica dahurica, the dried root of Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f. or Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f.var.formosana (Boiss.) Shan et Yuan, is a common medicinal and edible material that can dispel wind, dry dampness, reduce swelling and relieve pain. It can treat headache, brow pain, toothache, sinusitis, cold and damp abdominal pain, intestinal wind and hemorrhoids, leucorrhea, carbuncle, itchy skin, and scabies. Photosensitization: The furanocoumarin compounds such as bergamotol, zanthoxylum toxin, and isoimperatorin B contained in this product are photoactive substances. Once they enter the body and are exposed to sunlight or ultraviolet rays, they can cause solar dermatitis on the exposed skin, causing redness, swelling, increased pigmentation, and thickening of the skin. The photosensitizing activity of Zanthoxylum bungeanum is the strongest, followed by bergamotolone, and isoimperatorin B is weaker. Photosensitizing substances can be used to treat vitiligo. Isoimperatorin is an effective ingredient for treating psoriasis, and its effectiveness has been proven by clinical erythema measurement.

[0019] Black sesame is the dried mature seeds of Sesamumindicum L., a plant of the genus Sesamumindicum in the family Sesamum (Pedalaceae). It is a common medicinal and edible material. Black sesame can be used as medicine. It tastes sweet and is neutral in nature. It enters the liver, spleen, and kidney meridians, and has the effects of tonifying the liver and kidney, nourishing blood and improving essence, and moistening the intestines and relieving constipation. It is mainly used to treat dizziness and tinnitus, weak waist and legs, premature graying of hair, dry skin, dry intestines and constipation, insufficient milk in women, carbuncles and eczema, epilepsy, pediatric diseases, burns, hemorrhoids and other diseases caused by liver and kidney deficiency.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] The invention uses peach kernel, galangal, angelica dahurica and black sesame. The invention uses peach kernel as the main medicine for promoting blood circulation and removing blood stasis, galangal and angelica dahurica as the assistant medicine for dispelling wind and cold, and black sesame as the adjuvant for tonic effect. The four medicines and foods are used in combination to play the effect of treating vitiligo. Animal experiments show that the peach kernel, galangal, angelica dahurica and black sesame medicine composition provided by the invention can achieve an effective rate of 70% in treating vitiligo.

[0022] Animal experiments show that the medicinal composition of the present invention, which is four kinds of medicine and food, selected from peach kernel, galangal, angelica dahurica and black sesame, can enhance the activity of tyrosinase, increase the serum tyrosinase content of vitiligo model guinea pigs, accelerate the synthesis of melanin, and at the same time enhance the activity of serum α-melanocyte stimulating hormone, increase the serum α-melanocyte stimulating hormone content of vitiligo model guinea pigs, and help promote the production of skin melanin and protect melanocytes.

[0023] The PIG3V cell test shows that the four edible and medicinal compositions selected from the present invention, namely peach kernel, galangal, angelica dahurica and black sesame, have a better protective effect on PIG3V cells under oxidative stress, reduce the production and accumulation of active oxygen in the vitiligo epidermis, help regulate the epidermal microenvironment, reduce the effects of inflammation, promote melanocyte apoptosis, and promote melanocyte proliferation. DETAILED DESCRIPTION

[0024] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0025] Unless otherwise specified, the experimental methods used in the embodiments of the present invention are all conventional methods.

[0026] Unless otherwise specified, the materials, reagents, etc. used in the embodiments of the present invention can be obtained from commercial sources.

[0027] The pharmacological investigations of the drug composition of the present invention on vitiligo rats were conducted on the basis of the safety of the drug proved by acute toxicity tests and long-term toxicity tests, and the dosages administered in the experimental studies were all within the safe dosage range.

[0028] Example 1

[0029] The medicine-food dual-purpose composition for treating vitiligo has the following formula:

[0030] 2 parts peach kernel powder, 1 part galangal powder, 1 part angelica powder and 2 parts black sesame powder.

[0031] The preparation method of peach kernel powder is as follows: crush peach kernels, add water to the peach kernels to extract twice according to the mass ratio of peach kernel powder to water of 1:10, each time for 2 hours, filter, combine the filtrate, concentrate, spray dry, and obtain peach kernel powder;

[0032] The preparation method of galangal powder is as follows: crush galangal, add 60% ethanol by volume to galangal according to the mass ratio of galangal powder to ethanol of 1:6, perform reflux extraction twice, each extraction is 2 hours, concentrate to a relative density of 1.1-1.2, spray dry, and obtain galangal powder.

[0033] The preparation method of Angelica dahurica powder is as follows: crush the Angelica dahurica, add water to the Angelica dahurica for water extraction twice according to the mass ratio of the Angelica dahurica powder to water being 1:12, each extraction lasting 2 hours, filtering, concentrating after combining the filtrate, and spray drying to obtain the Angelica dahurica powder.

[0034] Example 2

[0035] The medicine-food dual-purpose composition for treating vitiligo has the following formula:

[0036] 1 part peach kernel powder, 1 part galangal powder, 2 parts angelica powder and 2 parts black sesame powder.

[0037] The preparation methods of peach kernel powder, galangal powder, angelica dahurica powder and black sesame powder are the same as those in Example 1.

[0038] Comparative Example 1

[0039] The medicine-food dual-purpose composition for treating vitiligo has the following formula:

[0040] 2 parts of angelica powder, 1 part of galangal powder, 1 part of angelica powder and 2 parts of black sesame powder.

[0041] The preparation method of angelica powder is as follows: crush the angelica, add water to the angelica for water extraction twice according to the mass ratio of angelica powder to water of 1:10, each extraction lasts for 2 hours, filter, combine the filtrate and concentrate, spray dry, and obtain angelica powder.

[0042] The preparation methods of galangal powder, angelica dahurica powder and black sesame powder are the same as those in Example 1.

[0043] Comparative Example 2

[0044] The medicine-food dual-purpose composition for treating vitiligo has the following formula:

[0045] 2 parts peach kernel powder, 1 part galangal powder, 1 part astragalus powder and 2 parts black sesame powder.

[0046] The preparation method of astragalus powder is as follows: crush the astragalus, add water to the astragalus according to the mass ratio of astragalus powder to water of 1:10, boil for 4 hours, filter, concentrate the filtrate, spray dry, and obtain the astragalus powder.

[0047] The preparation methods of peach kernel powder, galangal powder and black sesame powder are the same as those in Example 1.

[0048] Test Example 1

[0049] 1 Materials

[0050] 1.1 Experimental drugs and reagents

[0051] 1.1.1 Drugs

[0052] The edible and medicinal compositions for treating vitiligo prepared in the examples and comparative examples were selected, and commercially available vitiligo capsules (specification 0.45 g×10 capsules×12 plates, Yangling Wuwei Pharmaceutical Co., Ltd.) were used.

[0053] 1.2 Experimental cells

[0054] The epidermal melanocyte cell line (PIG3V) was purchased from the BioVector NTCC plasmid vector strain cell protein antibody gene storage center.

[0055] 2 Methods

[0056] PIG3V cells were subcultured using 254 melanocyte culture medium containing 5% fetal bovine serum, and the constant temperature incubator was adjusted to 37°C and 5% CO 2 , the subculture rate was 1:2-1:3, 0.25% trypsin was added for digestion, and the digestion was terminated after about 50% of the cells fell off.

[0057] PIG3V cells were seeded in 96-well plates at a cell concentration of 5 × 10 4 / mL, 200μL system, adjust the constant temperature incubator conditions to 37℃, 5% CO 2 The cells were cultured until 80% of the cells adhered to the wall. The cells were divided into a control group, a drug administration group and a commercially available group. The drug administration group and the commercially available group were added with the medicinal and edible compositions for treating vitiligo prepared in the examples and comparative examples and commercially available capsules (final concentration 400 μM), respectively. After culturing for 12 h, 0.75 mM H 2 O 2 PIG3V cells were subjected to oxidative stress treatment. The control group was treated with 254 melanocyte culture medium for 12 h, and then 0.75 mM / L H 2 O 2 PIG3V cells were subjected to oxidative stress and then incubated at 37°C and 5% CO 2 After culturing for 24 h, the proliferation activity of cells was detected by MTS method.

[0058] 3 Experimental results

[0059] Compared with the control group, the addition of the medicine and food dual-purpose composition has different degrees of promoting effect on the proliferation of PIG3V cells. Compared with the comparative example, the medicine and food dual-purpose composition prepared in the embodiment has a better protective effect on PIG3V cells under oxidative stress, reduces the generation and accumulation of vitiligo epidermal reactive oxygen, helps to regulate the epidermal microenvironment, reduces the effect of inflammation, promotes melanocyte apoptosis, and promotes melanocyte proliferation, and the effect is better than that of commercial products. The results are shown in Table 1.

[0060] Table 1 Effect of the medicinal and edible composition on the proliferation of PIG3V cells under oxidative stress (-x±s)

[0061]

[0062] Test Example 2

[0063] 1 Materials

[0064] 1.1 Experimental drugs and reagents

[0065] 1.1.1 Drugs

[0066] The medicinal and edible composition for treating vitiligo prepared in Example 1 was selected.

[0067] 1.2 Experimental animals

[0068] Fifty black guinea pigs, weighing 300-400 g, half male and half female, were provided by the Experimental Animal Center of Shandong University of Traditional Chinese Medicine.

[0069] 2 Methods

[0070] 2.1 Modeling method and grouping

[0071] Fifty black guinea pigs weighing 300-400g, half male and half female, were randomly divided into a blank group, a model group, a high-dose group, a medium-dose group, and a low-dose group, with 10 in each group. The black skin on the back of the guinea pig was selected as the modeling site. The long hair on the modeling site was first cut off with scissors, and then the short hair was shaved with an electric shaver, leaving an area of ​​about 5cm×5cm for modeling. The residual black short hair in the shaved area was removed with a depilatory cream. A 2.5% hydroquinone solution was applied to the depilated area at a dose of 0.1g / kg, once in the morning and once in the evening, for 21 consecutive days to establish a vitiligo guinea pig model. The blank group was applied with an equal amount of distilled water at the same number of times every day. All guinea pigs except the blank group were confirmed to have successfully established the model by dermoscopy. Guinea pigs in the blank group and the model group were given an equal volume of pure water by gavage 3 times a day. The high-dose group, medium-dose group, and low-dose group were gavaged at a dose of 0.9g / (kg·d), 0.6g / (kg·d), and 0.4g / (kg·d), respectively, 3 times a day, and once every 6 hours. The gavage lasted for 21 days. During the administration period, the guinea pigs in each group were depilated once every 2 days with a depilatory cream in the test area, and the skin color changes of the guinea pigs were closely observed during the experiment.

[0072] 2.2 Determination of TYR and α-MSH levels in guinea pig serum

[0073] Before the first administration, blood was collected from the hind limb vein of each group of guinea pigs. The blood was centrifuged at a speed of 3500r / min for 15min and serum was obtained and stored in a -80℃ refrigerator. The required strips were taken out from the aluminum foil bag after equilibration at room temperature for 60min, and the remaining strips were sealed with a ziplock bag and returned to 4℃. Standard wells, blank wells and sample wells were set up, and 50μL of standards of different concentrations were added to each standard well. 50μL of the sample to be tested was added to the sample well; 50μL of sample diluent was added to the blank well. 100μL of detection antibody labeled with horseradish peroxidase (Peroxidase, HRP) was added to each of the blank wells, standard wells and sample wells, and the reaction wells were sealed with a sealing film, and incubated in a 37℃ constant temperature box for 60min. The liquid was discarded, patted dry on absorbent paper, and each well was filled with washing solution (350μL), left to stand for 1min, the washing solution was shaken off, and patted dry on absorbent paper. Repeat the washing 5 times. Add 50 μL of substrate A and B to each well and incubate at 37°C in the dark for 15 minutes. Add 50 μL of stop solution to each well and measure the OD value of each well at a wavelength of 450 nm within 15 minutes. Measure the levels of tyrosinase (TYR) and α-melanocyte stimulating hormone (α-MSH) in serum; after the last administration, blood was collected from the heart of guinea pigs, and the levels of tyrosinase (TYR) and α-melanocyte stimulating hormone (α-MSH) in serum were measured by the same method.

[0074] 3 Experimental Results

[0075] 3.1 Model making

[0076] Guinea pigs in the blank control group did not show any depigmentation after being smeared with distilled water for 21 days. In the model group, the high, medium and low dose treatment groups, spot-like skin depigmentation began to appear on the 15th day of the experiment, and on the 20th day, the skin of the modeling guinea pigs showed varying degrees of depigmentation on the modeling site.

[0077] 3.2 Discoloration

[0078] The depigmentation of the guinea pigs' skin in the test area was observed with the naked eye to evaluate the efficacy. The efficacy was divided into effective and ineffective. Ineffective: the appearance of color islands and pigment spots in the test area was less than 5% or no change; effective: the appearance of color islands and pigment spots in the test area was ≥5%, effective rate = effective number / total number of guinea pigs × 100%, ineffective rate = ineffective number / total number of guinea pigs × 100%.

[0079] 3.3 Observation of drug efficacy

[0080] The effective rate of the high-dose group was 70%, the effective rate of the medium-dose group was 70%, the effective rate of the low-dose group was 50%, and the effective rate of the model group was 0%. The data of the five groups were statistically significant (χ 2 =14.265, P<0.05). There was no statistical difference between the high-dose group and the medium-dose group (P>0.05), and there was no statistical difference between the high-dose group and the low-dose group (P>0.05). The results are shown in Table 2.

[0081] Table 2 The efficacy of the medicine-food combination on vitiligo animal models [n (%)]

[0082]

[0083] Note: *P<0.05 compared with the model group.

[0084] 3.3 Effects on melanin in vitiligo animal models

[0085] The distribution of melanin in epidermal basal cells and stratum spinosum and the number of melanin hair follicles in each group increased significantly, and there were significant differences compared with the model control group (P<0.05). The results are shown in Table 3.

[0086] Table 3 Effect of the medicinal and edible composition on melanin in vitiligo animal models (-x±s)

[0087]

[0088] Note: *P<0.05 compared with the model group; "±" indicates occasional melanin, "++++" indicates more than 85% melanin, "+++" indicates 51-85% melanin, and "++" indicates 30-50% melanin.

[0089] 3.4 Effect on serum tyrosinase levels in vitiligo guinea pig models

[0090] Comparison of serum tyrosinase levels before treatment and after treatment showed significant differences (P<0.05). Comparison of serum tyrosinase levels in the five groups after treatment showed significant differences (P<0.05), as shown in Table 4.

[0091] Table 4 Effect of the medicine-food combination on tyrosinase before and after treatment (-x±s)

[0092]

[0093] Note: *Compared with the blank group, P<0.05; #Compared with the model group, P<0.05.

[0094] 2.5 Effect on serum α-melanocyte stimulating hormone content in vitiligo guinea pig model

[0095] The serum α-melanocyte stimulating hormone level before treatment was compared with the serum α-melanocyte stimulating hormone level after treatment, and the difference was statistically significant (P<0.05), as shown in Table 5.

[0096] Table 5 Effect of the medicinal and edible composition on serum α-melanocyte stimulating hormone before and after treatment (-x±s)

[0097]

[0098] Note: *Compared with the blank group, P<0.05; #Compared with the model group, P<0.05.

[0099] 4 Conclusion and discussion

[0100] As a copper-binding metal enzyme, tyrosinase can catalyze tyrosine to generate dopamine and dopaquinone, so it plays a key role in melanin synthesis, allowing melanocytes to produce melanin. The basic pathological change of vitiligo is the reduction or disappearance of melanocytes. The experimental results of establishing a vitiligo guinea pig model indicate that the present invention selects four medicinal and edible homologous combinations of peach kernel, galangal, angelica dahurica and black sesame, which can enhance the activity of tyrosinase, increase the serum tyrosinase content of vitiligo model guinea pigs, and accelerate the synthesis of melanin, indicating that peach kernel, galangal, angelica dahurica and black sesame have certain therapeutic effects for the treatment of vitiligo.

[0101] Serum α-melanocyte stimulating hormone, also known as melanocyte-stimulating hormone, mainly stimulates melanin secretion, promotes the formation of melanocyte dendrites and protects melanocytes. The experimental results of establishing a vitiligo guinea pig model also suggest that the combination of peach kernel, galangal, angelica dahurica and black sesame can enhance the activity of serum α-melanocyte stimulating hormone, increase the serum α-melanocyte stimulating hormone of vitiligo model guinea pigs, and promote the production of skin melanin.

[0102] This experimental study shows that different doses have a good therapeutic effect on the vitiligo animal model, which increases the serum tyrosinase and serum α-melanocyte stimulating hormone of guinea pigs. This indicates that the combination of peach kernel, galangal, angelica dahurica and black sesame can significantly improve the pathological changes of vitiligo guinea pigs, providing a basis for its wide clinical application.

[0103] The above is a preferred embodiment of the present invention. It should be pointed out that a person skilled in the art can make several improvements and modifications without departing from the principle of the present invention. These improvements and modifications are also considered to be within the scope of protection of the present invention.

Claims

1. A medicine and food composition for treating vitiligo, characterized in that: The invention comprises the following components by weight: 1 to 8 parts of peach kernel, 1 to 8 parts of galangal, 1 to 8 parts of angelica dahurica and 1 to 8 parts of black sesame.

2. A medicinal and edible composition for treating vitiligo according to claim 1, characterized in that: The invention comprises the following components by weight: 2 to 6 parts of peach kernel, 1 to 3 parts of galangal, 1 to 3 parts of angelica dahurica and 2 to 6 parts of black sesame.

3. A medicine and food dual-purpose composition for treating vitiligo according to claim 1 or 2, characterized in that: The peach kernel is peach kernel powder, and the preparation method of the peach kernel powder comprises the following steps: crushing the peach kernel, adding water for water extraction, filtering, concentrating the filtrate, spray drying, and obtaining the peach kernel powder; the mass ratio of the peach kernel powder to the water is 1:8-15, and the water extraction is performed 1-3 times, each time for 1-3 hours.

4. A medicinal and edible composition for treating vitiligo according to claim 1 or 2, characterized in that: The galangal is galangal powder. The preparation method of the galangal powder comprises the following steps: crushing the galangal, adding ethanol for reflux extraction, concentrating, and spray drying to obtain the galangal powder; the mass ratio of the galangal powder to the ethanol is 1:4-7, the volume concentration of the ethanol is 50%-70%, the reflux extraction is performed 1-3 times, each extraction takes 1-3 hours, and the concentration is performed to a relative density of 1.1-1.

2.

5. A medicinal and edible composition for treating vitiligo according to claim 1 or 2, characterized in that: The angelica dahurica powder is prepared by crushing the angelica dahurica, adding water to perform water extraction, filtering, concentrating the filtrate, and spray drying to obtain the angelica dahurica powder; the water extraction is performed 1 to 3 times, each time for 1 to 3 hours.

6. A medicinal and edible composition for treating vitiligo according to claim 1 or 2, characterized in that: The sesame is black sesame powder. The preparation method of black sesame powder includes taking black sesame, squeezing out oil, taking the residue for low-temperature drying, and crushing to 90-110 meshes to obtain black sesame powder; the squeezing temperature is 35-55°C, the time is 2-5h, and the low-temperature drying temperature is 25-35°C, and the time is 0.5-5h.

7. A preparation for treating vitiligo, characterized in that: The medicine-food dual-purpose composition according to any one of claims 1 to 6 is mixed with medically acceptable adjuvants to prepare a preparation; the dosage form of the preparation includes powder, granules, pills, tablets, suspension or oral solution.

8. Use of the preparation according to claim 7 in treating vitiligo.

9. The use according to claim 8, characterized in that: The vitiligo is qi stagnation and blood stasis type vitiligo.

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