Separation and purification process of collagen

Abstract

The invention discloses a separation and purification process of collagen, and relates to the field of collagen processing. The collagen separation and purification process comprises a separation and purification box, the lower end of one side of the separation and purification box is communicated with a discharge pipe, and the collagen separation and purification process further comprises a centrifugal filter cartridge arranged in the separation and purification box; a T-shaped sliding groove is formed in the bottom of the centrifugal filter cartridge; the T-shaped sliding block is connected into the T-shaped sliding groove in the bottom of the centrifugal filter cartridge in a sliding manner; when the collagen extracting solution is separated and purified in a centrifugal mode, the removal effect of impurities in the collagen extracting solution can be guaranteed, and the impurities attached to the wall of the centrifugal filter drum can be peeled off; therefore, the separation and purification effect of the collagen extracting solution can be guaranteed, the speed of the collagen extracting solution penetrating through the centrifugal filter cartridge can be increased, and the separation and purification treatment efficiency of the collagen extracting solution is effectively improved.

Description

Technical Field

[0001] The invention belongs to the technical field of collagen processing, and in particular relates to a separation and purification process of collagen. Background Art

[0002] Collagen is a biopolymer, the main component of animal connective tissue, and the most abundant and widely distributed functional protein in mammals, accounting for 25% to 30% of the total protein, and even more than 80% in some organisms. Collagen has good biocompatibility, biodegradability and biological activity, so it is widely used in food, medicine, tissue engineering, cosmetics and other fields. In the process of processing and producing collagen in existing factories, some impurities may be mixed into the collagen extract, so it needs to be separated and purified.

[0003] Methods for separating and purifying collagen extracts include salting out, dialysis, centrifugation, electrophoresis and chromatography, among which salting out, centrifugation and electrophoresis are the most commonly used. Since a single method is difficult to fully separate and purify collagen, the actual operation is to achieve the purpose of separating and purifying collagen through a composite method.

[0004] In the prior art, when the collagen extract is separated and purified by centrifugation, although the centrifugal filter can intercept some impurities in the collagen extract in the cartridge, the impurities intercepted in the cartridge will adhere to the cartridge wall under the action of centrifugal force, causing clogging of the filter holes on the cartridge wall, thereby having a certain impact on the rate at which the collagen extract passes through the filter holes. In view of this, the present invention is specially proposed. Summary of the invention

[0005] The technical problem to be solved by the present invention is to overcome the deficiencies of the prior art and provide a collagen separation and purification process that can overcome the above problems or at least partially solve the above problems.

[0006] In order to solve the above technical problems, the basic concept of the technical solution adopted by the present invention is: a collagen separation and purification process, including a separation and purification box, a lower end of one side of the separation and purification box is connected to a discharge pipe, and also includes: a centrifugal filter cartridge, arranged inside the separation and purification box; a T-shaped slide groove is provided at the bottom of the centrifugal filter cartridge; a T-shaped slider is slidably connected in the T-shaped slide groove at the bottom of the centrifugal filter cartridge; a drive motor is fixedly connected to the center position of the bottom of the separation and purification box; a square connecting column is arranged in the separation and purification box and is fixedly connected to the output end of the drive motor, a square groove is provided on the T-shaped slider, and the square connecting column is detachable from the square groove of the T-shaped slider; an inclined convex plate is fixedly connected to the inner wall of the separation and purification box at equal distances around the circumference; a circle of the outer wall of the centrifugal filter cartridge is fixedly connected with a plurality of first hinge seats at equal distances around the circumference, and the first hinge seats are arranged in multiple rows at equal distances in the vertical direction; a second rolling wheel is rotatably connected to the first hinge seat.

[0007] In order to facilitate pressurizing the interior of the separation and purification box so that the collagen extract can be quickly discharged from the separation and purification box through the discharge pipe, the box further includes a box cover, which covers the opening at the upper end of the separation and purification box, and a plurality of self-resetting airbags are equidistantly fixedly connected to the inclined surface of the inclined convex plate, and the plurality of self-resetting airbags are connected in series with each other through air pipes, and the upper end of the self-resetting airbag located above is connected to the exhaust pipe, and a one-way valve is installed at the air inlet of the self-resetting airbag, and the air inlet end of the self-resetting airbag extends out of the separation and purification box.

[0008] In order to improve the sealing between the box cover and the separation and purification box and prevent the gas entering the separation and purification box through the self-resetting airbag from escaping through the gap between the box cover and the separation and purification box, further, a circle of sealing gaskets used in conjunction with the box cover are installed at the opening at the upper end of the separation and purification box.

[0009] In order to facilitate the filtering and purification of the gas entering the separation and purification box through the self-righting airbag, and to prevent some impurities such as dust from entering the separation and purification box along with the gas and mixing into the collagen extract to pollute it, further, the outer wall of the separation and purification box is fixedly connected to a fixed frame near the outlet end of the self-righting airbag, and an activated carbon adsorption plate is installed in the fixed frame.

[0010] In order to facilitate the rapid disassembly and replacement of the activated carbon adsorption plate, further, a first magnetic circle is fixedly connected to the outer side of the activated carbon adsorption plate, and a second magnetic circle that is magnetically attracted to the first magnetic circle is fixedly connected to the fixed frame.

[0011] In order to facilitate the centrifugal filter cartridge to rotate more smoothly during rapid rotation, further, the bottom of the centrifugal filter cartridge is rotatably connected to a plurality of second hinge seats equidistantly in a circle, and the second hinge seats are rotatably connected to a first rolling wheel.

[0012] In order to facilitate the graded purification of the collagen extract, further, the centrifugal filter cartridge is provided with a first centrifugal filter chamber, a second centrifugal filter chamber and a third centrifugal filter chamber from the inside to the outside, and the filter hole diameters on the upper side of the chamber wall of the first centrifugal filter chamber, the second centrifugal filter chamber and the third centrifugal filter chamber gradually decrease from the inside to the outside.

[0013] In order to facilitate the scraping of impurities attached to the walls of the first centrifugal filter bin, the second centrifugal filter bin and the third centrifugal filter bin, thereby preventing the impurities from clogging the filter holes of the first centrifugal filter bin, the second centrifugal filter bin and the third centrifugal filter bin and affecting the rate at which the collagen extract passes through the filter holes, further, two scrapers are symmetrically arranged in the first centrifugal filter bin, the second centrifugal filter bin and the third centrifugal filter bin, and the scrapers slide against the walls of the first centrifugal filter bin, the second centrifugal filter bin and the third centrifugal filter bin, and the scrapers are connected to the box cover by a connecting assembly.

[0014] Furthermore, the connecting assembly includes a connecting frame, a connecting rod and a tension spring. The scrapers located on the same side are connected by a connecting rod. The connecting rod is laterally fixed to the box cover. The connecting frame is slidably connected to the connecting rod. The tension spring is sleeved on the connecting rod, and its two ends are respectively fixedly connected to the connecting frame and the box cover.

[0015] In order to facilitate the staff to check the separation and purification status of the collagen extract inside the separation and purification box, an observation window is further fixedly installed on the separation and purification box.

[0016] After adopting the above technical scheme, the present invention has the following beneficial effects compared with the prior art: the present invention uses a separation and purification box, a driving motor, a square column, a centrifugal filter cartridge, a T-shaped slide groove, a T-shaped slider, a second rolling wheel and an inclined convex plate. When the collagen extract is separated and purified by centrifugation, it can not only ensure the removal effect of impurities in the collagen extract, but also can peel off the impurities attached to the wall of the centrifugal filter cartridge, thereby ensuring the effect of separating and purifying the collagen extract while increasing the rate at which the collagen extract passes through the centrifugal filter cartridge, thereby effectively improving the efficiency of separating and purifying the collagen extract.

[0017] The specific implementation modes of the present invention are further described in detail below in conjunction with the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In the attached picture:

[0019] Figure 1 This is a schematic front view of a collagen separation and purification process proposed by the present invention;

[0020] Figure 2 This is a schematic structural diagram of a collagen separation and purification process proposed by the present invention;

[0021] Figure 3 A partial structural diagram of a collagen separation and purification process proposed by the present invention Figure 1 ;

[0022] Figure 4 A partial structural diagram of a collagen separation and purification process proposed by the present invention Figure 2 ;

[0023] Figure 5 A separation and purification process of collagen proposed by the present invention Figure 2 The structural diagram of part A in the figure;

[0024] Figure 6 A separation and purification process of collagen proposed by the present invention Figure 3 Schematic diagram of the structure of part B.

[0025] In the figure: 1. separation and purification box; 101. box cover; 102. sealing gasket; 103. inclined convex plate; 104. self-resetting airbag; 105. fixing frame; 106. activated carbon adsorption plate; 107. first magnetic circle; 108. second magnetic circle; 109. observation window; 2. driving motor; 201. square connecting column; 3. centrifugal filter cartridge; 301. T-shaped slide groove; 302. T-shaped slider; 303. first rolling wheel; 304. first centrifugal filter chamber; 305. second centrifugal filter chamber; 306. third centrifugal filter chamber; 307. second rolling wheel; 4. scraper; 401. connecting frame; 402. connecting rod; 403. tension spring. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. The following embodiments are used to illustrate the present invention but are not used to limit the scope of the present invention.

[0027] Embodiment 1:

[0028] Reference Figure 1-Figure 6, a separation and purification process of collagen, comprising a separation and purification box 1, a discharge pipe is connected to the lower end of one side of the separation and purification box 1, and also comprising: a centrifugal filter cartridge 3, which is arranged inside the separation and purification box 1; a T-shaped slide groove 301 is provided at the bottom of the centrifugal filter cartridge 3; a T-shaped slider 302 is slidably connected in the T-shaped slide groove 301 at the bottom of the centrifugal filter cartridge 3; a driving motor 2 is fixedly connected to the center position of the bottom of the separation and purification box 1; a square connecting column 201 is arranged in the separation and purification box 1 and is fixedly connected to the output end of the driving motor 2, a square groove is provided on the T-shaped slider 302, and the square connecting column 201 is detachable from the square groove of the T-shaped slider 302; an inclined convex plate 103 is fixedly connected to the inner wall of the separation and purification box 1 at equidistant intervals on the circumference; a circle of the outer wall of the centrifugal filter cartridge 3 is fixedly connected with a plurality of first hinge seats at equidistant intervals on the circumference, and the first hinge seats are equidistantly arranged in multiple rows in the vertical direction; a second rolling wheel 307 is rotatably connected to the first hinge seat.

[0029] When the preparation of the collagen extract is completed and the impurities in the collagen extract need to be filtered out in order to improve the purity of the collagen extract, the staff can pour the collagen extract into the centrifugal filter cartridge 3, and then part of the collagen extract will slowly pass through the filter holes of the centrifugal filter cartridge 3 into the separation and purification box 1, and be discharged through the discharge pipe. The staff only needs to place a collection tank at the position of the discharge pipe to collect the separated and purified collagen extract.

[0030] After the collagen extract is poured into the centrifugal filter cartridge 3, the drive motor 2 can be started, and the drive motor 2 will drive the square connecting column 201 to rotate, and the square connecting column 201 will drive the centrifugal filter cartridge 3 to rotate rapidly through the T-shaped slider 302, and then the collagen extract in the centrifugal filter cartridge 3 will quickly pass through the filter holes under the action of centrifugal force and enter the separation and purification box 1, while some impurities in the collagen extract will be intercepted in the centrifugal filter cartridge 3.

[0031] At the same time, since the bottom of the centrifugal filter cartridge 3 is provided with a T-shaped slide groove 301 used in conjunction with the T-shaped slide block 302, when the centrifugal filter cartridge 3 rotates rapidly, the centrifugal filter cartridge 3 will be thrown to one side under the action of the rapid rotation, and then the second rolling wheel 307 on the side wall of the centrifugal filter cartridge 3 will abut against the inner wall of the separation and purification box 1. Since a plurality of inclined convex plates 103 are provided on the inner wall of the separation and purification box 1, when the second rolling wheel 307 rolls onto the inclined convex plate 103, the centrifugal filter cartridge 3 will be moved in the opposite direction to the centrifugal force under the action of the inclined convex plate 103. When the second rolling wheel 307 leaves the inclined convex plate 103, the centrifugal filter cartridge 3 will drive the second rolling wheel 307 to contact the inner wall of the separation and purification box 1 again under the action of centrifugal force, and repeat this process, so that the centrifugal filter cartridge 3 can rotate in a circle under the action of centrifugal force and shake in an undulating manner at the same time, thereby stripping off impurities attached to the wall of the centrifugal filter cartridge 3, so that the collagen extract can flow out of the centrifugal filter cartridge 3 through the filter holes more smoothly, thereby effectively improving the efficiency of separating and purifying the collagen extract.

[0032] Furthermore, when the second rolling wheel 307 leaves the inclined convex plate 103 and again hits the separation and purification box 1 under the swing of centrifugal force, the second rolling wheel 307 will generate vibration with the separation and purification box 1, and then the generated vibration force will be transmitted to the centrifugal filter cartridge 3, and then the impurities attached to the centrifugal filter cartridge 3 will be more fully peeled off under the action of the vibration force, further improving the rate at which the collagen extract passes through the centrifugal filter cartridge 3.

[0033] When the separation and purification of collagen is completed, the drive motor 2 can be turned off, and the centrifugal filter cartridge 3 will stop rotating. The centrifugal filter cartridge 3 can then be taken out of the separation and purification box 1, and the impurities intercepted in the centrifugal filter cartridge 3 can then be removed.

[0034] It should be noted that in order to improve the separation and purification efficiency of the collagen extract, while the collagen extract is being centrifuged and purified, the collagen extract can be continuously added to the centrifugal filter cartridge 3 through a conveying device, so that the collagen extract can be continuously separated and purified, thereby improving the processing efficiency of the collagen extract.

[0035] Embodiment 2:

[0036] Reference Figure 1-Figure 6, a separation and purification process of collagen includes a separation and purification box 1, a discharge pipe is connected to the lower end of one side of the separation and purification box 1, and also includes: a centrifugal filter cartridge 3, which is arranged inside the separation and purification box 1; a T-shaped slide groove 301 is provided at the bottom of the centrifugal filter cartridge 3; a T-shaped slider 302 is slidably connected in the T-shaped slide groove 301 at the bottom of the centrifugal filter cartridge 3; a driving motor 2 is fixedly connected to the center position of the bottom of the separation and purification box 1; a square connecting column 201 is provided in the separation and purification box 1 and is fixedly connected to the output end of the driving motor 2, a square groove is provided on the T-shaped slider 302, and the square connecting column 201 is detachable from the square groove of the T-shaped slider 302; an inclined convex plate 103 is fixedly connected to the inner wall of the separation and purification box 1 at equidistant intervals on the circumference; a circle of the outer wall of the centrifugal filter cartridge 3 is fixedly connected with a plurality of first hinge seats at equidistant intervals on the circumference, and the first hinge seats are arranged in multiple rows at equidistant intervals in the vertical direction; a second rolling wheel 307 is rotatably connected to the first hinge seat, and further:

[0037] The box cover 101 is also included. The box cover 101 covers the opening at the upper end of the separation and purification box 1. A plurality of self-resetting airbags 104 are fixedly connected to the inclined surface of the inclined convex plate 103 at equal intervals. The plurality of self-resetting airbags 104 are connected in series through air pipes. The upper end of the self-resetting airbag 104 located at the upper end is connected to the exhaust pipe. A one-way valve is installed at the air inlet of the self-resetting airbag 104. The air inlet end of the self-resetting airbag 104 extends out of the separation and purification box 1. When the second rolling wheel 307 rolls onto the self-resetting airbag 104, The gas in the self-righting airbag 104 will be squeezed out under the pressure applied by the second rolling wheel 307, and then the gas will enter the separation and purification box 1. The second rolling wheel 307 will continuously apply pressure back and forth to the self-righting airbag 104, and the air pressure in the separation and purification box 1 will continue to increase. Then, when the separated and purified collagen extract is discharged, the collagen extract will be quickly discharged from the separation and purification box 1 through the discharge pipe under the action of the air pressure, thereby effectively improving the efficiency of discharging the collagen extract.

[0038] A circle of sealing gasket 102 used in conjunction with the box cover 101 is installed at the opening at the upper end of the separation and purification box 1. When the box cover 101 is closed on the separation and purification box 1, the setting of the sealing gasket 102 can further improve the sealing between the box cover 101 and the separation and purification box 1, and prevent the gas entering the separation and purification box 1 through the self-resetting airbag 104 from escaping through the gap between the box cover 101 and the separation and purification box 1, thereby effectively ensuring the effect of gas pressurizing the collagen extract.

[0039] Embodiment 3:

[0040] Reference Figure 1-Figure 6, a separation and purification process of collagen, comprising a separation and purification box 1, a discharge pipe being connected to the lower end of one side of the separation and purification box 1, and also comprising: a centrifugal filter cartridge 3, arranged inside the separation and purification box 1; a T-shaped slide groove 301 is provided at the bottom of the centrifugal filter cartridge 3; a T-shaped slider 302 is slidably connected in the T-shaped slide groove 301 at the bottom of the centrifugal filter cartridge 3; a driving motor 2 is fixedly connected to the center position of the bottom of the separation and purification box 1; a square connecting column 201 is provided in the separation and purification box 1 and is fixedly connected to the output end of the driving motor 2, a square groove is provided on the T-shaped slider 302, and the square connecting column 201 is detachably connected to the square groove of the T-shaped slider 302; an inclined convex plate 103 is fixedly connected to the separation and purification box 1 at equidistant intervals on the circumference. On the inner wall of the separation and purification box 1; the outer wall of the centrifugal filter cartridge 3 is circumferentially equidistantly fixedly connected with a plurality of first hinge seats, and the first hinge seats are equidistantly arranged in multiple rows in the vertical direction; the second rolling wheel 307 is rotatably connected to the first hinge seat, and also includes a box cover 101, the box cover 101 covers the opening at the upper end of the separation and purification box 1, and a plurality of self-resetting airbags 104 are equidistantly fixedly connected on the inclined surface of the inclined convex plate 103, and the plurality of self-resetting airbags 104 are connected in series with each other through an air pipe, and the upper end of the self-resetting airbag 104 located above is connected to the exhaust pipe, and a one-way valve is installed at the air inlet of the self-resetting airbag 104, and the air inlet end of the self-resetting airbag 104 extends out of the separation and purification box 1, and further:

[0041] A fixed frame 105 is fixedly connected to the outer wall of the separation and purification box 1 near the air outlet end of the self-resetting airbag 104, and an activated carbon adsorption plate 106 is installed in the fixed frame 105. Through the arrangement of the fixed frame 105 and the activated carbon adsorption plate 106, the gas entering the separation and purification box 1 through the self-resetting airbag 104 can be filtered and purified to prevent some impurities such as dust from entering the separation and purification box 1 along with the gas and mixing into the collagen extract to pollute it, thereby effectively ensuring the purity of the collagen extract.

[0042] A first magnetic circle 107 is fixedly connected to the outer side of the activated carbon adsorption plate 106, and a second magnetic circle 108 that is magnetically attracted to the first magnetic circle 107 is fixedly connected inside the fixed frame 105. By using the first magnetic circle 107 and the second magnetic circle 108 that are magnetically attracted to each other, when the activated carbon adsorption plate 106 is used, the activated carbon adsorption plate 106 can be firmly adsorbed and fixed in the fixed frame 105, thereby ensuring the stability of the activated carbon adsorption plate 106 in the fixed frame 105. When the activated carbon adsorption plate 106 needs to be disassembled and replaced, it is only necessary to pull the handle on the activated carbon adsorption plate 106 outward to quickly remove the activated carbon adsorption plate 106 from the fixed frame 105 for replacement, thereby effectively improving the disassembly and assembly efficiency of the staff in disassembling and replacing the activated carbon adsorption plate 106.

[0043] Embodiment 4:

[0044] Reference Figure 1-Figure 6 , a collagen separation and purification process is basically the same as Example 3, and further, the bottom of the centrifugal filter cartridge 3 is rotatably connected with multiple second hinge seats at equal intervals in a circle, and the second hinge seat is rotatably connected with a first rolling wheel 303. Through the setting of the first rolling wheel 303, when the driving motor 2 drives the centrifugal filter cartridge 3 to rotate rapidly through the T-shaped slider 302, the centrifugal filter cartridge 3 can be supported by the first rolling wheel 303 to rotate more smoothly, thereby effectively ensuring the stability of the rotation of the centrifugal filter cartridge 3.

[0045] An observation window 109 is fixedly installed on the separation and purification box 1. By setting the observation window 109 on the separation and purification box 1, when the collagen extract is separated and purified, the staff can view the separation and purification of the collagen extract inside the separation and purification box 1 through the observation window 109, which provides convenience for the staff.

[0046] Embodiment 5:

[0047] Reference Figure 1-Figure 6 , a collagen separation and purification process is basically the same as Example 4, and further, a first centrifugal filter chamber 304, a second centrifugal filter chamber 305 and a third centrifugal filter chamber 306 are respectively opened in the centrifugal filter cartridge 3 from the inside to the outside, and the filter hole diameters on the upper sides of the first centrifugal filter chamber 304, the second centrifugal filter chamber 305 and the third centrifugal filter chamber 306 gradually decrease from the inside to the outside. By sequentially arranging the first centrifugal filter chamber 304, the second centrifugal filter chamber 305 and the third centrifugal filter chamber 306 with gradually decreasing filter hole diameters from the inside to the outside in the centrifugal filter cartridge 3, when the collagen extract is centrifuged and purified, the collagen extract can be graded and purified, which can not only avoid the filter holes of the first centrifugal filter chamber 304, the second centrifugal filter chamber 305 and the third centrifugal filter chamber 306 from being quickly blocked, affecting the penetration rate of the collagen extract, but also can further improve the separation and purification effect of the collagen extract.

[0048] Two scrapers 4 are symmetrically arranged in the first centrifugal filter chamber 304, the second centrifugal filter chamber 305 and the third centrifugal filter chamber 306. The scrapers 4 slide against the walls of the first centrifugal filter chamber 304, the second centrifugal filter chamber 305 and the third centrifugal filter chamber 306. The scrapers 4 are connected to the box cover 101 through a connecting assembly. The connecting assembly includes a connecting frame 401, a connecting rod 402 and a tension spring 403. The scrapers 4 on the same side are connected through the connecting rod 402. The connecting rod 402 is laterally fixedly connected to the box cover 101. The connecting frame 401 is slidably connected to the connecting rod 402. The tension spring 403 is sleeved on the connecting rod 402, and the two ends are respectively connected to the connecting rod 402. The frame 401 and the box cover 101 are fixedly connected. Since the scraper 4 is always tightly attached to the walls of the first centrifugal filter chamber 304, the second centrifugal filter chamber 305 and the third centrifugal filter chamber 306 under the tension of the tension spring 403, when the centrifugal filter cylinder 3 rotates, the scraper 4 can scrape off the impurities attached to the walls of the first centrifugal filter chamber 304, the second centrifugal filter chamber 305 and the third centrifugal filter chamber 306, thereby preventing the impurities from clogging the filter holes of the first centrifugal filter chamber 304, the second centrifugal filter chamber 305 and the third centrifugal filter chamber 306 and affecting the rate at which the collagen extract passes through the filter holes, thereby effectively improving the separation and purification rate and effect of the collagen extract.

[0049] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention has been disclosed as above with a preferred embodiment, it is not used to limit the present invention.

Claims

1. A process for separation and purification of collagen, characterized in that: The invention comprises a separation and purification box (1), wherein a discharge pipe is connected to a lower end of one side of the separation and purification box (1), and further comprises: A centrifugal filter cartridge (3) is arranged inside the separation and purification box (1); A T-shaped slide groove (301) is provided at the bottom of the centrifugal filter cartridge (3); A T-shaped sliding block (302) slidably connected in the T-shaped sliding groove (301) at the bottom of the centrifugal filter cartridge (3); A driving motor (2) is fixedly connected to the center of the bottom of the separation and purification box (1); A square connecting column (201) is arranged in the separation and purification box (1) and is fixedly connected to the output end of the driving motor (2); a square groove is provided on the T-shaped slider (302); and the square connecting column (201) is detachably connected to the square groove of the T-shaped slider (302); Inclined convex plates (103) are fixedly connected to the inner wall of the separation and purification box (1) at equidistant intervals around the circumference; A plurality of first hinged seats are fixedly connected to the outer wall of the centrifugal filter cartridge (3) at equal intervals in a circumference, and the first hinged seats are arranged in multiple rows at equal intervals in the vertical direction; The second rolling wheel (307) is rotatably connected to the first hinge seat.

2. A collagen separation and purification process according to claim 1, characterized in that: It also comprises a box cover (101), the box cover (101) covers the opening at the upper end of the separation and purification box (1), a plurality of self-resetting airbags (104) are fixedly connected at equal intervals on the inclined surface of the inclined convex plate (103), the plurality of self-resetting airbags (104) are connected in series with each other through air pipes, the upper end of the self-resetting airbag (104) located at the top is connected to the exhaust pipe, a one-way valve is installed at the air inlet of the self-resetting airbag (104), and the air inlet end of the self-resetting airbag (104) extends out of the separation and purification box (1).

3. A collagen separation and purification process according to claim 2, characterized in that: A sealing gasket (102) is installed at the opening at the upper end of the separation and purification box (1) and is used in conjunction with the box cover (101).

4. A collagen separation and purification process according to claim 2, characterized in that: A fixing frame (105) is fixedly connected to the outer wall of the separation and purification box (1) at a position close to the gas outlet of the self-resetting airbag (104), and an activated carbon adsorption plate (106) is installed in the fixing frame (105).

5. A collagen separation and purification process according to claim 4, characterized in that: A first magnetic circle (107) is fixedly connected to the outer side of the activated carbon adsorption plate (106), and a second magnetic circle (108) that is magnetically attracted to the first magnetic circle (107) is fixedly connected to the inside of the fixed frame (105).

6. A collagen separation and purification process according to claim 1, characterized in that: The bottom of the centrifugal filter cartridge (3) is rotatably connected to a plurality of second hinged seats at equal intervals in a circle, and the second hinged seats are rotatably connected to a first rolling wheel (303).

7. A collagen separation and purification process according to claim 3, characterized in that: The centrifugal filter cartridge (3) is provided with a first centrifugal filter bin (304), a second centrifugal filter bin (305) and a third centrifugal filter bin (306) from the inside to the outside, respectively; the diameters of the filter holes on the upper sides of the bin walls of the first centrifugal filter bin (304), the second centrifugal filter bin (305) and the third centrifugal filter bin (306) gradually decrease from the inside to the outside.

8. A collagen separation and purification process according to claim 7, characterized in that: Two scrapers (4) are symmetrically arranged in the first centrifugal filter bin (304), the second centrifugal filter bin (305) and the third centrifugal filter bin (306); the scrapers (4) are slidably attached to the bin walls of the first centrifugal filter bin (304), the second centrifugal filter bin (305) and the third centrifugal filter bin (306); and the scrapers (4) are connected to the box cover (101) via a connecting component.

9. A collagen separation and purification process according to claim 8, characterized in that: The connecting assembly comprises a connecting frame (401), a connecting rod (402) and a tension spring (403); the scrapers (4) located on the same side are connected via the connecting rod (402); the connecting rod (402) is laterally fixedly connected to the box cover (101); the connecting frame (401) is slidably connected to the connecting rod (402); the tension spring (403) is sleeved on the connecting rod (402), and the two ends are respectively fixedly connected to the connecting frame (401) and the box cover (101).

10. A collagen separation and purification process according to claim 1, characterized in that: An observation window (109) is fixedly mounted on the separation and purification box (1).

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