Mixing equipment for pharmaceutical production

Abstract

The invention discloses mixing equipment for pharmaceutical production, and relates to the technical field of pharmaceutical production. The two spiral mixing air inlet channels are arranged on the circumferential surface of the batch mixing chamber and are arranged in the tangential direction of the inner wall of the batch mixing chamber, so that kinetic energy of spiral airflow can be effectively utilized through the structural design; the medicines can be uniformly distributed in the batch mixing chamber in the mixing process, so that the problem of non-uniform mixing of the medicines in a traditional mixing device is avoided, and the mixing efficiency and the mixing quality are remarkably improved; a baffle plate fixing pipe arranged in the mixing barrel and a plurality of baffle plates which are fixedly mounted on the inner wall of the baffle plate fixing pipe and are spirally and crossly arranged can generate turbulent flow in the mixing process, so that the uniformity of medicine mixing is further improved. Due to the spiral arrangement of the baffle plate, the medicine particles can be effectively dispersed and crushed in the mixing process, and the problem of caking of the medicine particles in the mixing process is avoided.

Description

Technical Field

[0001] The invention relates to the technical field of medicine production, in particular to a mixing device for medicine production. Background Art

[0002] In the prior art, drug mixing devices generally have problems such as uneven mixing, drug particle agglomeration, and air inlet channel blockage. Especially when processing large quantities of drugs, traditional devices are difficult to ensure uniform mixing and efficient separation of drugs. Traditional mixing devices usually use simple stirring or vibration methods, which cannot fully utilize the kinetic energy and pressure difference effects of the airflow, resulting in unsatisfactory mixing effects, and the drug purity and quality are difficult to meet the expected standards. In addition, when processing different quantities of drugs, traditional devices lack a flexible adjustment mechanism, which easily causes waste of drugs and reduced mixing effects. Summary of the invention

[0003] In order to overcome the defects of the above-mentioned prior art, the present invention provides the following technical solutions: a mixing device for drug production, comprising a mixing barrel and a batch mixing chamber, wherein two spiral mixing air inlet channels are symmetrically arranged about the axis center of the batch mixing chamber on the circumferential surface of the batch mixing chamber, and the two spiral mixing air inlet channels are arranged along the tangent direction of the inner wall of the batch mixing chamber, and a loading barrel is fixedly provided on the two spiral mixing air inlet channels, and a negative pressure air inlet pipe is fixedly connected at the bottom of the batch mixing chamber; wherein a baffle plate fixing tube is slidably installed on the inner wall of the mixing barrel, and a plurality of spirally cross-arranged baffle plates are fixedly installed on the inner wall of the baffle plate fixing tube for disturbing the spiral airflow, and two accelerating air inlet pipes are fixedly connected at the bottom of the mixing barrel along the tangent direction of the inner wall, and the two accelerating air inlet pipes are fixedly connected to the ventilation circular ring tube arranged on the outer side of the bottom of the mixing barrel.

[0004] Preferably, the feeding barrel, the spiral mixing air inlet channel and the interior of the batch mixing chamber are connected, and the inner wall bottom surfaces of the feeding barrel and the spiral mixing air inlet channel are flush with each other, the top of the batch mixing chamber is fixedly connected to a second conical guide cover, and the top of the second conical guide cover is fixedly connected to a feeding guide bypass pipe.

[0005] Preferably, a circular ring bracket is fixedly installed on the top of the baffle plate fixing tube, two supporting slide rods are fixedly installed on the outer surface of the mixing barrel, the two supporting slide rods are slidably matched with the circular ring bracket, and a first conical guide cover is fixedly installed on the circular ring bracket, and the first conical guide cover is communicated with the interior of the baffle plate fixing tube.

[0006] Preferably, a dynamic sliding feed pipe is fixedly connected to the first conical guide cover, and a top support frame is fixed to the top of the two supporting slide rods, wherein the dynamic sliding feed pipe is slidably matched with the top support frame, and two limiting stop tubes are also fixedly installed on the top support frame, and limiting solenoid valves are installed on the tops of the two limiting stop tubes. Limiting stop pistons are slidably sealed on the inner walls of the two limiting stop tubes, and the two limiting stop pistons are fixedly matched with the first conical guide cover through two limiting stop rods.

[0007] Preferably, it also includes an aggregate pool, a discharge nozzle is provided at the bottom of the aggregate pool, a discharge screw is rotatably installed at the bottom of the inner wall of the aggregate pool and in the discharge nozzle, a distribution cover is fixedly connected to the aggregate pool, a distribution chamber is coaxially provided in the distribution cover, a gap is left between the circumferential surface of the distribution chamber and the inner wall of the distribution cover, and the bottom of the distribution chamber and the bottom of the distribution cover are fixedly matched in a sealing arrangement.

[0008] Preferably, a plurality of tangential feed grooves are provided on the circumferential surface of the distribution chamber along its own tangential direction, wherein the interior of the distribution cover is communicated with the interior of the distribution chamber through the tangential feed grooves.

[0009] Preferably, a separation gas pipe is coaxially fixedly installed inside the material distribution chamber, one end of the separation gas pipe is fixed to the top of the inner wall of the material distribution chamber, the other end of the separation gas pipe passes through the gathering pool and extends to the outside of the gathering pool, and a plurality of ventilation holes are provided on the separation gas pipe at a position coaxial with the material distribution chamber.

[0010] Preferably, an air filter can be installed inside the separation gas pipe, one end of the separation gas pipe away from the material distribution chamber is connected to the air inlet of the air pump, an air collecting hood is provided at the exhaust port of the air pump, and the exhaust port of the air pump blows air into the air collecting hood. The air collecting hood partially blocks the exhaust port of the air pump, so that some air can enter the air collecting hood.

[0011] Preferably, the air collecting hood is connected to the inside of the ventilation annular tube through an air supply pipe, and the air collecting hood bulges toward the inside of the ventilation annular tube, so that a spiral airflow is formed inside the mixing cylinder.

[0012] Preferably, a fixed sliding feed pipe is fixedly installed on the top support frame, the fixed sliding feed pipe is slidably sleeved on the outer surface of the movable sliding feed pipe, the material distribution cover and the interior of the fixed sliding feed pipe are fixedly connected through a feed guide pipe, a connecting valve is installed in series on the feed guide pipe, and the feed guide pipe and the interior of the second conical guide cover are fixedly connected through a feed guide bypass pipe.

[0013] Compared with the prior art, the present invention has the following beneficial effects: (1) The present invention provides two spiral mixing air inlet channels on the circumferential surface of the batch mixing chamber, and the two spiral mixing air inlet channels are provided along the tangent direction of the inner wall of the batch mixing chamber. This structural design can effectively utilize the kinetic energy of the spiral airflow, so that the medicine can be evenly distributed in the batch mixing chamber during the mixing process, avoiding the problem of uneven mixing of medicines in traditional mixing devices, and significantly improving the mixing efficiency and mixing quality; (2) The baffle fixing tube provided inside the mixing barrel of the present invention and the multiple spirally cross-arranged baffles fixedly installed on the inner wall can generate turbulence during the mixing process, further improving the uniformity of the medicine mixing. Due to the spiral arrangement of the baffles, this design can also effectively disperse and break up the medicine particles during the mixing process, avoiding the problem of agglomeration of the medicine particles during the mixing process; (3) The present invention provides an air pump, an air collecting hood, a ventilation annular tube and their interconnected structural design, so that a stable spiral airflow can be formed inside the mixing barrel, thereby enhancing the mixing effect of the medicine in the mixing barrel. At the same time, through the setting of the negative pressure air inlet pipe, a negative pressure environment can be formed in the batch mixing chamber, and the pressure difference is used to achieve the inhalation and mixing of the medicines, avoiding the phenomenon of medicines blocking the air inlet channel during the loading process, and improving the stability and reliability of the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 It is a schematic diagram of the overall structure of the present invention.

[0015] Figure 2 It is a schematic diagram of the structure of the gas collecting hood of the present invention.

[0016] Figure 3 For the present invention Figure 2 Schematic diagram of the structure at point A in the middle.

[0017] Figure 4 It is a schematic diagram of the structure of the tangential feed trough of the present invention.

[0018] Figure 5 It is a schematic diagram of the structure of the batch mixing chamber of the present invention.

[0019] Figure 6 It is a structural schematic diagram of the fixed sliding feeding pipe of the present invention.

[0020] Figure 7 This is a schematic diagram of the structure of the limiting stop piston of the present invention.

[0021] Figure 8 It is a structural schematic diagram of the circular ring support of the present invention.

[0022] Fig. 9 It is a structural schematic diagram of the shielding plate of the present invention.

[0023] Fig.10It is a schematic diagram of the structure of the mixing cylinder of the present invention.

[0024] In the figure: 101-mixing cylinder; 102-shielding plate fixing pipe; 103-shielding plate; 104-acceleration air intake pipe; 105-ventilation annular pipe; 106-annular bracket; 107-first conical guide cover; 108-dynamic sliding feeding pipe; 109-supporting sliding rod; 110-limiting stay rod; 111-top supporting frame; 112-limiting stay pipe; 113-limiting solenoid valve; 114-fixed sliding feeding pipe; 115-limiting stay piston; 116-air supply Tube; 117-gas collecting hood; 118-air pump; 119-feeding guide pipe; 120-connecting valve; 121-distributing hood; 122-distributing chamber; 123-separation gas pipe; 124-collecting pool; 125-discharging screw; 126-feeding guide side pipe; 127-second conical guide hood; 128-batch mixing chamber; 129-negative pressure air inlet pipe; 130-loading barrel; 131-spiral mixing air inlet channel; 132-discharging nozzle; 133-tangential feeding trough. DETAILED DESCRIPTION

[0025] The following is combined with Figure 1-10 , and further illustrate the technical solution of the present invention through specific implementation methods.

[0026] The present invention provides a mixing device for drug production, comprising a mixing barrel 101 and a batch mixing chamber 128, wherein two spiral mixing air inlet channels 131 are symmetrically arranged about the axis center of the batch mixing chamber 128 on the circumferential surface of the batch mixing chamber 128, the two spiral mixing air inlet channels 131 are arranged along the tangent direction of the inner wall of the batch mixing chamber 128, and a loading barrel 130 is fixedly provided on the two spiral mixing air inlet channels 131, and a negative pressure air inlet pipe 129 is fixedly connected to the bottom of the batch mixing chamber 128; wherein a baffle plate fixing tube 102 is slidably installed on the inner wall of the mixing barrel 101, and a plurality of spirally cross-arranged baffle plates 103 are fixedly installed on the inner wall of the baffle plate fixing tube 102 for disturbing the spiral airflow, and two accelerating air inlet pipes 104 are fixedly connected to the bottom of the mixing barrel 101 along the tangent direction of the inner wall, and the two accelerating air inlet pipes 104 are fixedly connected to the ventilation annular tube 105 arranged on the outer side of the bottom of the mixing barrel 101. The loading barrel 130, the spiral mixing air inlet channel 131 and the batch mixing chamber 128 are connected to each other, and the inner wall bottom surfaces of the loading barrel 130 and the spiral mixing air inlet channel 131 are flush with each other. The top of the batch mixing chamber 128 is fixedly connected to the second conical guide cover 127, and the top of the second conical guide cover 127 is fixedly connected to the feed guide side pipe 126. The top of the baffle plate fixing tube 102 is fixedly installed with a circular ring bracket 106, and two support slide bars 109 are fixedly installed on the outer surface of the mixing barrel 101. The two support slide bars 109 are slidably matched with the circular ring bracket 106. The circular ring bracket 106 is fixedly installed with a first conical guide cover 107, and the first conical guide cover 107 is connected to the inside of the baffle plate fixing tube 102. A dynamic sliding feed tube 108 is fixedly connected to the first conical guide cover 107, and a top support frame 111 is fixed to the top of the two supporting slide rods 109, wherein the dynamic sliding feed tube 108 is slidably matched with the top support frame 111, and two limiting stop tubes 112 are also fixedly installed on the top support frame 111, and limiting solenoid valves 113 are installed on the tops of the two limiting stop tubes 112, and limiting stop pistons 115 are slidably sealed and installed on the inner walls of the two limiting stop tubes 112, and the two limiting stop pistons 115 are fixedly matched with the first conical guide cover 107 via two limiting stop rods 110.

[0027] It also includes a collection pool 124, the bottom of which is provided with a discharge nozzle 132, a discharge screw 125 is rotatably mounted at the bottom of the inner wall of the collection pool 124 and in the discharge nozzle 132, a distribution cover 121 is fixedly connected to the collection pool 124, a distribution chamber 122 is coaxially arranged in the distribution cover 121, a gap is left between the circumferential surface of the distribution chamber 122 and the inner wall of the distribution cover 121, and the bottom of the distribution chamber 122 and the bottom of the distribution cover 121 are fixedly matched in a sealed arrangement. A plurality of tangential feed slots 133 are provided on the circumferential surface of the distribution chamber 122 along its own tangential direction, wherein the interior of the distribution cover 121 is connected to the interior of the distribution chamber 122 through the tangential feed slots 133. A separation gas pipe 123 is coaxially fixedly installed inside the distribution chamber 122, one end of the separation gas pipe 123 is fixed to the top of the inner wall of the distribution chamber 122, and the other end of the separation gas pipe 123 passes through the collection pool 124 and extends to the outside of the collection pool 124, and a plurality of vents are provided on the separation gas pipe 123 at a position coaxial with the distribution chamber 122. An air filter element can be installed inside the separation gas pipe 123, and one end of the separation gas pipe 123 away from the distribution chamber 122 is connected to the air inlet of the air pump 118, and an air collecting hood 117 is provided at the exhaust port of the air pump 118, and the exhaust port of the air pump 118 blows air into the air collecting hood 117. The air collecting hood 117 partially blocks the exhaust port of the air pump 118, so that some air can enter the air collecting hood 117. The air collecting hood 117 is connected to the inside of the ventilation annular tube 105 through the air supply pipe 116, and the air collecting hood 117 bulges into the inside of the ventilation annular tube 105, so that a spiral airflow is formed inside the mixing barrel 101. A fixed sliding feed pipe 114 is fixedly installed on the top support frame 111, and the fixed sliding feed pipe 114 is slidably sleeved on the outer surface of the dynamic sliding feed pipe 108. The material distribution hood 121 is fixedly connected to the inside of the fixed sliding feed pipe 114 through a feed guide pipe 119, and a connecting valve 120 is installed in series on the feed guide pipe 119. The feed guide pipe 119 is fixedly connected to the inside of the second conical guide hood 127 through a feed guide bypass pipe 126.

[0028] If the number of mixed medicines is large, pour the medicines into the corresponding loading barrels 130 respectively, and then start the air pump 118. The air inlet of the air pump 118 generates a negative pressure environment inside the collecting pool 124 through the separation gas pipe 123 (because the collecting pool 124 is connected to the inside of the distributing chamber 122, and the separation gas pipe 123 is connected to the inside of the distributing chamber 122). It is necessary to block the discharge nozzle 132 in advance. The negative pressure will pass through the distributing chamber 122, the tangential feeding trough 133, the distributing cover 121, the feeding guide pipe 119, the connecting valve 120 in the open state, the fixed sliding feeding pipe 114, and the dynamic sliding feeding pipe 108 into the mixing barrel 101 (the baffle fixing pipe 102), and because the exhaust port of the air pump 118 is connected to the air collecting cover 117, the air collecting cover 117 is connected to the ventilation ring pipe through the air supply pipe 116. 105 is connected, and the ventilation annular tube 105 is connected to the mixing barrel 101 through the accelerating air inlet pipe 104. At this time, a spiral airflow will be formed in the mixing barrel 101 under the action of the air pressure difference. Since the diameter of the air supply pipe 116 is much smaller than the diameter of the feeding guide pipe 119, most of the air will enter the batch mixing chamber 128 from the negative pressure air inlet pipe 129 (the batch mixing chamber 128, the feeding guide side pipe 126, and the feeding guide pipe 119 are interconnected). At this time, a negative pressure environment is formed in the batch mixing chamber 128, and the medicine poured into the loading barrel 130 will be sucked into the batch mixing chamber 128 under the action of the pressure difference, and spirally mixed in the batch mixing chamber 128. It should be noted that too much medicine cannot be poured into the loading barrel 130 at one time, otherwise the spiral mixing air inlet channel 131 will be blocked. Under the action of the pressure difference, the mixed medicine will follow the second conical guide cover 127, the second conical guide cover 127, the feeding guide tube 119, and enter the dividing cover 121, and then pass through the tangential feed groove 133 and enter the dividing chamber 122 tangentially along the inner wall of the dividing chamber 122, thereby rotating inside the dividing chamber 122. During the rotation, the medicine powder will lean against the inner wall of the dividing chamber 122 under the action of centrifugal force, while the middle part is the separated air, which will enter the separation gas pipe 123 and then enter the air pump 118.

[0029] If the amount of mixed medicine is small, it is necessary to first block the loading barrel 130 and the negative pressure air inlet pipe 129. Then open the limiting solenoid valve 113 to allow the inside of the limiting stop pipe 112 to be connected. Since the ventilation annular tube 105 will supply air to the inside of the mixing barrel 101, the internal pressure of the mixing barrel 101 will increase. At this time, under the action of pressure, the gas will slide upward on the inner wall of the mixing barrel 101 against the baffle plate fixing tube 102. When the baffle plate fixing tube 102 slides to a certain height, the user lifts the baffle plate fixing tube 102 out of the mixing barrel 101 by hand, and then closes the limiting solenoid valve 113. After the limiting solenoid valve 113 is closed, the inside of the limiting stop pipe 112 is in a closed state. At this time, under the action of the pressure difference, the limiting stop piston 115 cannot slide in the limiting stop pipe 112. Therefore, under the restriction of the limiting stop rod 110, the limiting stop pipe 112 will be fixed at a certain height position. At this time, the air pump 118 is first stopped, and the user pours the required mixed medicine into the mixing barrel 101 at one time, and then opens the limiting solenoid valve 113. Under the action of gravity, the baffle plate fixing tube 102 falls back into the mixing barrel 101. When the baffle plate fixing tube 102 completely falls into the mixing barrel 101, the limiting solenoid valve 113 is closed. At this time, since the loading barrel 130 and the negative pressure air inlet pipe 129 are in a blocked state, all the air will enter the mixing barrel 101 from the air collecting hood 117, the air supply pipe 116, the ventilation ring pipe 105, and the accelerating air inlet pipe 104. Since the diameter of the accelerating air inlet pipe 104 is relatively small, it will be injected into the mixing barrel 101 as a high-speed airflow under the action of the pressure difference. The high-speed airflow will rotate in the mixing barrel 101, and turbulence will be formed under the shielding of the baffle plate 103 set on the baffle fixing tube 102, thereby increasing the uniformity of the drug mixing. Then the mixed drug powder will pass through the first conical guide hood 107, the dynamic sliding feed tube 108, the fixed sliding feed tube 114, and the feed guide tube 119 into the distribution hood 121, thereby separating the air and the drug. The separated medicines will fall into the collecting pool 124. When they need to be discharged, the blocked discharge nozzle 132 will be opened, and then a motor will be used to drive the discharge screw 125 to rotate. The discharge screw 125 rotates to discharge the medicines inside the collecting pool 124.

Claims

1. A mixing device for pharmaceutical production, characterized in that: The invention comprises a mixing barrel (101) and a batch mixing chamber (128), wherein two spiral mixing air inlet channels (131) are symmetrically arranged on the circumferential surface of the batch mixing chamber (128) about the axis center of the batch mixing chamber (128), the two spiral mixing air inlet channels (131) are arranged along the tangent direction of the inner wall of the batch mixing chamber (128), a loading barrel (130) is fixedly arranged on the two spiral mixing air inlet channels (131), and a negative pressure air inlet pipe (129) is fixedly arranged at the bottom of the batch mixing chamber (128); A baffle plate fixing tube (102) is slidably mounted on the inner wall of the mixing cylinder (101); a plurality of baffle plates (103) arranged in a spiral cross pattern are fixedly mounted on the inner wall of the baffle plate fixing tube (102) for disturbing the spiral airflow; two accelerating air intake tubes (104) are fixedly connected and arranged at the bottom of the mixing cylinder (101) along the tangent direction of the inner wall; the two accelerating air intake tubes (104) are fixedly connected and arranged with a ventilation annular tube (105) arranged on the outer side of the bottom of the mixing cylinder (101); It also includes a material collection pool (124), the bottom of the material collection pool (124) is provided with a material discharge nozzle (132), a material discharge screw (125) is rotatably mounted at the bottom of the inner wall of the material collection pool (124) and in the material discharge nozzle (132), a material distribution cover (121) is fixedly connected to the material collection pool (124), a material distribution chamber (122) is coaxially arranged in the material distribution cover (121), a gap is left between the circumferential surface of the material distribution chamber (122) and the inner wall of the material distribution cover (121), and the bottom of the material distribution chamber (122) and the bottom of the material distribution cover (121) are fixedly matched in a sealed arrangement; the inside of the material distribution chamber (122) is coaxially fixed A separation gas pipe (123) is installed, and an air filter can be installed inside the separation gas pipe (123). One end of the separation gas pipe (123) away from the material distribution chamber (122) is connected to the air inlet of the air pump (118). An air collecting hood (117) is provided at the exhaust port of the air pump (118), and the exhaust port of the air pump (118) blows air into the air collecting hood (117); the air collecting hood (117) is connected to the inside of the ventilation annular tube (105) through an air supply pipe (116), and the air blows into the inside of the ventilation annular tube (105) through the air collecting hood (117), so that a spiral airflow is formed inside the mixing cylinder (101).

2. A mixing device for drug production according to claim 1, characterized in that: The loading barrel (130), the spiral mixing air inlet passage (131) and the batch mixing chamber (128) are internally connected, and the inner wall bottom surfaces of the loading barrel (130) and the spiral mixing air inlet passage (131) are flush with each other. The top of the batch mixing chamber (128) is fixedly connected to a second conical guide cover (127), and the top of the second conical guide cover (127) is fixedly connected to a feed guide bypass pipe (126).

3. A mixing device for drug production according to claim 2, characterized in that: A circular bracket (106) is fixedly mounted on the top of the baffle plate fixing tube (102); two supporting slide bars (109) are fixedly mounted on the outer surface of the mixing barrel (101); the two supporting slide bars (109) are slidably matched with the circular bracket (106); a first conical guide cover (107) is fixedly mounted on the circular bracket (106); and the first conical guide cover (107) is communicated with the interior of the baffle plate fixing tube (102).

4. A mixing device for drug production according to claim 3, characterized in that: A movable sliding feeding tube (108) is fixedly connected to the first conical guide cover (107), and a top support frame (111) is fixedly provided at the top ends of the two support slide bars (109), wherein the movable sliding feeding tube (108) is slidably matched with the top support frame (111), and two limiting stop tubes (112) are also fixedly installed on the top support frame (111), and limiting solenoid valves (113) are installed at the tops of the two limiting stop tubes (112), and limiting stop pistons (115) are slidably sealed on the inner walls of the two limiting stop tubes (112), and the two limiting stop pistons (115) are fixedly matched with the first conical guide cover (107) via two limiting stop rods (110).

5. A mixing device for drug production according to claim 4, characterized in that: A plurality of tangential feed grooves (133) are provided on the circumferential surface of the material distribution chamber (122) along its own tangential direction, wherein the interior of the material distribution cover (121) is communicated with the interior of the material distribution chamber (122) via the tangential feed grooves (133).

6. A mixing device for drug production according to claim 5, characterized in that: One end of the separation gas pipe (123) is fixed to the top of the inner wall of the material distribution chamber (122), and the other end of the separation gas pipe (123) passes through the material collection pool (124) and extends to the outside of the material collection pool (124), and a plurality of ventilation holes are provided on the separation gas pipe (123) at a position coaxial with the material distribution chamber (122).

7. A mixing device for drug production according to claim 6, characterized in that: A fixed sliding feed pipe (114) is fixedly mounted on the top support frame (111). The fixed sliding feed pipe (114) is slidably sleeved on the outer surface of the movable sliding feed pipe (108). The material distribution cover (121) is fixedly connected to the interior of the fixed sliding feed pipe (114) via a feed guide pipe (119). A connecting valve (120) is installed in series on the feed guide pipe (119). The feed guide pipe (119) is fixedly connected to the interior of the second conical guide cover (127) via a feed guide bypass pipe (126).

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