Preparation method of PVC (polyvinyl chloride) / PE (polyethylene) / PVDC (polyvinyl dichloride) composite hard sheet for ultrahigh-barrier medicine packaging

Abstract

According to the preparation method of the PVC / PE / PVDC composite hard sheet for ultrahigh-barrier medicine packaging, the prepared PVC / PE / PVDC composite hard sheet is good in comprehensive barrier performance and stable in structure, has certain bonding strength and can contain certain medicines, and the method is free of solvent residues, environmentally friendly and safe.

Description

Technical Field

[0001] The invention relates to the technical field of preparation of pharmaceutical packaging materials, and in particular to a method for preparing a PVC / PE / PVDC composite hard sheet for ultra-high barrier pharmaceutical packaging. Background Art

[0002] Plastic products are widely used due to their light weight, good corrosion resistance and low cost, especially in the field of medicine, where plastic composite films / plastic composite sheets are widely used. Moreover, with the rapid development of my country's pharmaceutical industry, the pharmaceutical packaging industry has gained a huge living space. The packaging quality of most domestic pharmaceutical products is far behind that of developed countries. At present, pharmaceutical blisters and polyvinyl chloride have existed in my country for many years. As a material for packaging drugs, it has good processing performance and light texture.

[0003] However, the water vapor and oxygen permeability of pharmaceutical polyvinyl chloride is large, which has a fatal impact on the stability of drug quality, greatly shortening the storage and warranty period of drugs. Dry composite process is generally used in production. The adhesive used in current pharmaceutical composite hard sheets is solvent-based adhesive, so it is inevitable that there is a trace amount of solvent residue in the product. When the residual solvent exceeds the standard, it may cause pollution to the drug and reduce the safety of the drug. In addition, the process treatment during the preparation process will also affect the residual amount of solvent.

[0004] In view of this, it is necessary for us to develop a preparation method of PVC / PE / PVDC composite hard sheet for ultra-high barrier pharmaceutical packaging based on existing technologies. Summary of the invention

[0005] In view of the deficiencies in the prior art, the present invention aims to provide a method for preparing a PVC / PE / PVDC composite hard sheet for ultra-high barrier pharmaceutical packaging.

[0006] To achieve the above object, the present invention proposes the following technical solutions:

[0007] A method for preparing a PVC / PE / PVDC composite hard sheet for ultra-high barrier pharmaceutical packaging comprises the following steps:

[0008] S1, PE composite

[0009] The PVC sheet is subjected to a first corona treatment to obtain a PVC layer; the treated PVC layer is allowed to stand for 2-10 minutes, and then a first rubber layer is coated on the bonding surface of the PVC layer, and a composite coating machine is used to bond the PE layer to the PVC layer to obtain a composite product A;

[0010] S2, first ripening

[0011] The composite product A of step S1 is placed for aging at 35-40° C. for 24-72 hours to obtain a pre-product;

[0012] S3, PVDC alternate coating

[0013] The pre-product of step S2 is subjected to a second corona treatment, and a second rubber layer is coated on the bonding surface of the PE layer, and a composite coating machine is used to bond the PVDC layer to the PE layer to obtain a composite product B;

[0014] S4, Second Ripening

[0015] The composite product B of step S3 is placed at 20-30° C. for aging for 24-72 hours to obtain a PVC / PE / PVDC composite hard sheet;

[0016] S5, Cutting

[0017] The PVC / PE / PVDC composite hard sheet is cut and packaged according to the use requirements.

[0018] On the basis of the above scheme and as a preferred scheme of the above scheme, the parameters of the composite coating machine for PE composite in step S1 are: composite coating speed 38-82m / min, drying temperature 68-85°C.

[0019] On the basis of the above scheme and as a preferred scheme of the above scheme, the parameters of the composite coating machine for the PVDC alternating coating in step S3 are: coating speed 40-45m / min, drying temperature 68-85°C.

[0020] On the basis of the above scheme and as a preferred scheme of the above scheme, the thickness of the PVC layer is 0.35-0.45 mm; the thickness of the PE layer is preferably 0.3-0.4 mm; and the thickness of the PVDC layer is 0.20-0.35 mm.

[0021] On the basis of the above scheme and as a preferred scheme of the above scheme, the dyne value of the first corona treatment is ≥30.

[0022] On the basis of the above scheme and as a preferred scheme of the above scheme, the dyne value of the second corona treatment is ≥30.

[0023] On the basis of the above solution and as a preferred solution of the above solution, the first rubber layer and the second rubber layer are both polyurethane rubber.

[0024] Compared with the prior art, the technical solution of the present invention has the following beneficial effects:

[0025] The invention discloses a PVC / PE / PVDC composite hard sheet for medicine packaging, which has good comprehensive barrier performance, stable structure, certain bonding strength, can hold certain medicines, and the method has no solvent residue, is environmentally friendly, safe, and can be widely promoted.

[0026] It should be appreciated that all combinations of the foregoing concepts, as well as additional concepts described in greater detail below, may be considered part of the present subject matter disclosure to the extent such concepts are not mutually inconsistent.

[0027] The foregoing and other aspects, embodiments and features of the present invention will be more fully understood from the following description. Other additional aspects of the present invention, such as the features and / or beneficial effects of the exemplary embodiments, will be apparent from the following description or will be learned from the practice of the specific embodiments according to the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] The above and / or additional aspects and advantages of the present invention will become apparent and easily understood from the description of the embodiments in conjunction with the following drawings, in which:

[0029] Figure 1 It is a schematic diagram of the structure of the PVC / PE / PVDC composite hard sheet of the present invention.

[0030] In the figure, 1, PVC layer; 2, first rubber layer; 3, second rubber layer; 4, PE layer; 5, PVDC layer. DETAILED DESCRIPTION

[0031] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme of the present invention will be clearly and completely described below in combination with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the described embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. Unless otherwise defined, the technical terms or scientific terms used herein should be the common meanings understood by people with general skills in the field to which the present invention belongs.

[0032] The words "first", "second" and similar words used in the patent application specification and claims of the present invention do not indicate any order, quantity or importance, but are only used to distinguish different components. Similarly, unless the context clearly indicates otherwise, the singular forms of "a", "an" or "the" and other similar words do not indicate a quantitative limitation, but indicate the existence of at least one. Words such as "include" or "comprise" mean that the elements or objects appearing before "include" or "comprise" cover the features, wholes, steps, operations, elements and / or components listed after "include" or "comprise", and do not exclude the existence or addition of one or more other features, wholes, steps, operations, elements, components and / or their collections. "Up", "down", "left", "right" and the like are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may also change accordingly.

[0033] With the continuous development of science and technology, researchers have been constantly innovating pharmaceutical packaging materials. Some people have developed PVC / PE / PVDC composite hard sheets. However, the barrier performance of existing PVC / PE / PVDC composite hard sheets for pharmaceutical packaging is not ideal. The specific data are shown in the following table:

[0034] Table 1 Barrier test data of existing PVC / PE / PVDC composite hard sheets for pharmaceutical packaging

[0035] Measured level <![CDATA[Oxygen transmission rate [cm 3 / (m 2 ·24h·0.1MPa)]]]> <![CDATA[Water vapor transmission rate [g / (m 2 ·24 h)]]]> <![CDATA[90g / m 2 ]]> ≤1.0 ≤0.25 <![CDATA[180g / m 2 ]]> ≤0.5 ≤0.12

[0036] As can be seen from Table 1 above, the barrier properties of existing PVC / PE / PVDC composite hard sheets for pharmaceutical packaging still cannot meet the long-term storage requirements of some sensitive drugs. Therefore, in order to further ensure the quality of drugs and meet the long-term storage requirements of drugs, we provide a method for preparing ultra-high barrier PVC / PE / PVDC composite hard sheets for pharmaceutical packaging.

[0037] The PVC / PE / PVDC composite hard sheet mentioned in the present invention is tested for performance using the following standard method:

[0038] Oxygen permeability: YBB00202005-2015 Polyvinyl chloride, polyethylene, polyvinylidene chloride solid pharmaceutical composite hard tablets.

[0039] Water vapor permeability: YBB00092003-2015 Polyvinyl chloride, polyethylene, polyvinylidene chloride solid pharmaceutical composite hard tablets.

[0040] Examples 1-3

[0041] The preparation method of the ultra-high barrier PVC / PE / PVDC composite hard sheet for pharmaceutical packaging mentioned in the present invention is as follows:

[0042] According to the process flow of "corona treatment → PE compounding → aging → corona treatment → PVDC alternating coating → aging → slitting", the PVC layer material is first corona treated, and then a layer of polyurethane adhesive is coated on the adhesive surface of the PVC layer to compound the PE layer; it is placed in an oven for aging at 35-40°C for 24-72 hours; then corona treatment is performed again, and then the PVDC layer is alternately coated and placed in an oven for aging at 20-30°C for 24-72 hours; finally, the PVC / PE / PVDC composite hard sheet is slit and packaged.

[0043] Among them, the dyne value of corona treatment is ≥30;

[0044] The parameters of the composite coating machine are: PE layer, composite speed 40m / min, drying temperature 68-85℃; PVDC layer coating speed 40-45m / min, drying temperature 68-85℃.

[0045] The concentration of the solution, the thickness of the PET layer, and the thickness of the PE layer are specifically shown in Table 2 below.

[0046] Table 2 Parameters of various embodiments

[0047] Example 1 Example 2 Example 3 Thickness of PVC layer (mm) 0.35 0.40 0.45 Thickness of PE layer (mm) 0.30 0.35 0.40 Thickness of PVDC layer (mm) 0.20 0.25 0.35 First aging temperature and time 40℃，24h 35℃，48h 35℃，72h First aging temperature and time 30℃，24h 25℃，48h 20℃，60h

[0048] The performance of the PVC / PE / PVDC composite hard sheet prepared above was tested and recorded in Table 3 below.

[0049] Table 3 Barrier test data of PVC / PE / PVDC composite hard sheet for drug packaging of the present invention

[0050] Measured level <![CDATA[Oxygen transmission rate [cm 3 / (m 2 ·24h·0.1MPa)]]]> <![CDATA[Water vapor transmission rate [g / (m 2 ·24 h)]]]> <![CDATA[90g / m 2 ]]> ≤0.5 ≤0.03 <![CDATA[180g / m 2 ]]> ≤0.2 ≤0.05

[0051] From Table 3 above, it can be seen that, compared with the existing composite hard sheets through oxygen permeability and water vapor permeability, the PVC / PE / PVDC composite hard sheet for pharmaceutical packaging of the present invention has better comprehensive barrier properties, stable structure, and certain bonding strength, and can hold certain drugs. Moreover, the method has no solvent residue, is environmentally friendly and safe.

[0052] As described above, the present invention can be preferably implemented.

[0053] The preferred specific embodiments of the present invention are described in detail above. It should be understood that a person skilled in the art can make many modifications and changes based on the concept of the present invention without creative work. Therefore, any technical solution that can be obtained by a person skilled in the art through logical analysis, reasoning or limited experiments based on the concept of the present invention on the basis of the prior art should be within the scope of protection determined by the claims.

Claims

1. A method for preparing a PVC / PE / PVDC composite hard sheet for ultra-high barrier pharmaceutical packaging, characterized in that: The following steps are involved: S1, PE composite The PVC sheet is subjected to a first corona treatment to obtain a PVC layer; the treated PVC layer is allowed to stand for 2-10 minutes, and then a first rubber layer is coated on the bonding surface of the PVC layer, and a composite coating machine is used to bond the PE layer to the PVC layer to obtain a composite product A; S2, first ripening The composite product A of step S1 is placed for aging at 35-40° C. for 24-72 hours to obtain a pre-product; S3, PVDC alternate coating The pre-product of step S2 is subjected to a second corona treatment, and a second rubber layer is coated on the bonding surface of the PE layer, and the PVDC layer is bonded to the PE layer using a composite coating machine to obtain a composite product B; S4, Second Ripening The composite product B of step S3 is placed at 20-30° C. for aging for 24-72 hours to obtain a PVC / PE / PVDC composite hard sheet; S5, Cutting The PVC / PE / PVDC composite hard sheet is cut and packaged according to the use requirements.

2. The method for preparing a PVC / PE / PVDC composite hard sheet for ultra-high barrier pharmaceutical packaging according to claim 1, characterized in that: The parameters of the composite coating machine for the PE composite in step S1 are: composite coating speed 38-82m / min, drying temperature 68-85°C.

3. The method for preparing a PVC / PE / PVDC composite hard sheet for ultra-high barrier pharmaceutical packaging according to claim 1, characterized in that: The parameters of the composite coating machine for the PVDC alternating coating in step S3 are: coating speed 40-45 m / min, drying temperature 68-85°C.

4. The method for preparing a PVC / PE / PVDC composite hard sheet for ultra-high barrier pharmaceutical packaging according to claim 1, characterized in that: The thickness of the PVC layer is 0.35-0.45 mm; the thickness of the PE layer is preferably 0.3-0.4 mm; and the thickness of the PVDC layer is 0.20-0.35 mm.

5. The method for preparing a PVC / PE / PVDC composite hard sheet for ultra-high barrier pharmaceutical packaging according to claim 1, characterized in that: The dyne value of the first corona treatment is ≥30.

6. The method for preparing a PVC / PE / PVDC composite hard sheet for ultra-high barrier pharmaceutical packaging according to claim 1, characterized in that: The dyne value of the second corona treatment is ≥30.

7. The method for preparing a PVC / PE / PVDC composite hard sheet for ultra-high barrier pharmaceutical packaging according to claim 1, characterized in that: The first rubber layer and the second rubber layer are both polyurethane rubber.

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