Plaque indicator and preparation method thereof

Abstract

The invention provides a plaque indicator and a preparation method thereof. The preparation method of the plaque indicator comprises the following steps: S100, preparing the antibacterial microcapsules; s200, mixing the bacteriostatic microcapsules with 1 / 5-2 / 5 of a solvent, uniformly stirring, and heating and dissolving at 40-60 DEG C to obtain a solution A; s300, adding the coloring agent, the friction agent, the filling agent, the enzyme and the flavoring agent into the residual solvent, and uniformly stirring to obtain a solution B; and S400, uniformly mixing and stirring the solution A and the solution B, and adding other auxiliary components to obtain the plaque indicator. According to the plaque indicator disclosed by the invention, through an accurate formula and a scientific component proportion, the problems of excessive dyeing, high cleaning difficulty and insufficient antibacterial effect in a traditional product are effectively solved, so that plaque detection and removal become simpler and more convenient, meanwhile, continuous oral protection is provided, and the oral care effect is remarkably improved.

Description

Technical Field

[0001] The invention relates to the technical field of daily chemical industry, in particular to a plaque indicator and a preparation method thereof. Background Art

[0002] Teeth cleaning and oral hygiene care are of great significance to improving physical health and have been paid more and more attention in recent years. Unhealthy teeth not only cause premature tooth loss and bring great inconvenience to life, but also cause a variety of diseases, such as heart disease, Alzheimer's disease, etc.

[0003] Traditional plaque indicators have three shortcomings: 1. They only have an indicator function through pigment staining and cannot assist in oral cleaning; 2. They are inconvenient to use and are too staining, causing the tongue and lips to be stained and difficult to clean; 3. The cleaning process is cumbersome and requires more time to brush teeth to remove pigment-stained plaque. Summary of the invention

[0004] Therefore, the present invention provides a plaque indicator and a preparation method thereof. The plaque indicator of the present application effectively solves the problems of excessive dyeing, difficulty in cleaning, and insufficient antibacterial effect existing in traditional products through precise formula and scientific ingredient ratio, making the detection and removal of plaque easier, while providing continuous oral protection and significantly improving the effect of oral care.

[0005] The invention provides a method for preparing a bacterial plaque indicator, wherein the bacterial plaque indicator comprises the following components in percentage by mass: antibacterial microcapsules: 2.0-5.0%; dye: 0.01-0.1%; abrasive: 1.0-5.0%; preservative: 0.05-0.15%; filler: 30.0-40.0%; enzyme: 0.1-1.0%; flavoring agent: 0.2-3%; other auxiliary components: 5.0-10.0%; solvent: balance; wherein the antibacterial component in the antibacterial microcapsules is one or more of tea tree oil and honeysuckle extract; the dye comprises gardenia blue; the other auxiliary components comprise softeners;

[0006] The preparation method of a plaque indicator comprises: S100, preparing antibacterial microcapsules; S200, mixing the antibacterial microcapsules with 1 / 5-2 / 5 of a solvent, stirring evenly, and heating to dissolve at 40°C-60°C to obtain a solution A; S300, adding a dye, a friction agent, a filler, an enzyme, and a flavoring agent to the remaining solvent, stirring evenly, to obtain a solution B; S400, mixing and stirring solution A and solution B evenly, and then adding other auxiliary components to obtain a plaque indicator.

[0007] Compared with the prior art, the technical effects achieved by adopting the technical scheme are as follows: the dye in the plaque indicator of the present application - gardenia blue combines with the cell wall of dental plaque to make it appear on the surface of the teeth, so that the plaque area is clearly visible, further guiding the user to clean the teeth more effectively, especially the hard-to-see parts are easy for the user to find and remove, and improving the effectiveness of the user's brushing and other oral cleaning methods; the antibacterial microcapsules can slowly release the antibacterial ingredients therein, such as tea tree oil and honeysuckle extract, which have natural antibacterial effects. These ingredients can inhibit the growth of bacteria in the oral cavity, prevent the formation of plaque, and help prevent caries, gingivitis and other oral diseases. At the same time, the microencapsulation technology ensures the stability and long-term effect of the antibacterial ingredients, so that the plaque indicator can continuously inhibit the growth of plaque; the abrasive improves the plaque removal effect and enhances the cleaning effect through physical friction. Combined with the dye, the user can better Accurately remove dental plaque; the addition of flavor correctives can improve the taste of the product, increase user acceptance and usage experience, and avoid the impact of bad taste on usage; the addition of enzymes such as protease and lipase can soften the colored dental plaque, and the addition of abrasives can make the dental plaque better detach from the teeth, providing convenience for subsequent cleaning; preservatives can prevent the product from being contaminated by microorganisms during storage and use, ensuring the stability and safety of the plaque indicator while extending the service life of the product; fillers serve as matrix materials to provide volume and viscosity for the entire product, making it easy to use without affecting the health of teeth and oral cavity; other auxiliary ingredients can improve the physical properties of the product, such as fluidity and spreadability, ensuring the convenience and stability of the product in actual use; solvents serve as media to dissolve and mix the various components so that the components can be evenly distributed in the product, ensuring consistent effects each time it is used.

[0008] In the preparation step, antibacterial microcapsules are prepared to encapsulate the antibacterial ingredients to form microcapsules, thereby improving the stability and controlled release performance of the antibacterial ingredients and ensuring a lasting antibacterial effect; secondly, the antibacterial microcapsules are mixed with part of the solvent, and the antibacterial microcapsules are mixed with part of the solvent and heated to dissolve to form a uniform solution A, thereby ensuring that the antibacterial microcapsules are evenly distributed and ensuring the stability of the antibacterial effect; furthermore, dyes, abrasives, fillers, enzymes and flavoring agents are added to the remaining solvent and stirred evenly to prepare solution B, thereby ensuring that the functional components are fully mixed and the functional effects of the components are realized; finally, the two parts of the solution are mixed, and auxiliary components are added to prepare a final product, thereby obtaining a final plaque indicator with uniform distribution and stability, thereby ensuring the effect and consistency of the product, thereby forming a product that can effectively visualize and inhibit oral plaque and help users better maintain oral hygiene.

[0009] In a technical solution of the present invention, the preparation of antibacterial microcapsules in S100 specifically includes: S110, adding porous cyclodextrin to deionized water and stirring evenly to obtain a wall material emulsion; S120, adding an antibacterial agent to deionized water, and then adding a surfactant, mixing evenly to obtain a core material emulsion; S130, after evenly mixing the wall material emulsion and the core material emulsion, spraying and drying them in sequence to obtain antibacterial microcapsules.

[0010] Compared with the prior art, the technical effect achieved by adopting this technical scheme is as follows: in S110, porous cyclodextrin is first added to deionized water and stirred evenly to obtain a wall material emulsion; porous cyclodextrin has a unique structure and can wrap and protect the active ingredients. Its porosity provides more surface area, so that it can effectively wrap the antibacterial agent and prevent the antibacterial agent from being oxidized or degraded during storage and use, thereby achieving the slow release of the active ingredient, which is beneficial to the continuous inhibition of bacterial growth in the oral cavity; deionized water is used as a solvent to ensure that the porous cyclodextrin is evenly dispersed in the solution to form a stable wall material emulsion; secondly, the antibacterial agent is added to the deionized water, and then a surfactant is added, and after mixing evenly, a core material emulsion is obtained; the antibacterial agent is the core component of the microcapsule, and its main function is to inhibit and kill pathogenic bacteria in the oral cavity and reduce the formation of plaque. Through microencapsulation, the antibacterial agent can be protected in the core material to reduce direct contact with the external environment, thereby maintaining its activity and stability. Qualitative; The surfactant can reduce the surface tension of the core material emulsion, prevent the antibacterial agent from aggregating into large particles in the water, and ensure that the antibacterial agent is evenly distributed in the solution; at the same time, it can also improve the permeability of the antibacterial agent during use, making it easier to diffuse to every corner of the oral cavity and enhancing the antibacterial effect; finally, the wall material emulsion and the core material emulsion are evenly mixed and then sprayed and dried in turn to obtain antibacterial microcapsules. By mixing the wall material emulsion and the core material emulsion, it is ensured that the antibacterial agent is evenly wrapped in the wall material formed by the porous cyclodextrin, which helps to form stable microcapsules and reduce the direct exposure of the antibacterial agent, thereby preventing it from being released or degraded in advance; The spraying treatment causes the liquid wall material and the core material to form tiny particles, which are then dried to form stable solid microcapsules, which have good storage stability and can gradually release the antibacterial agent during use; The drying treatment helps to remove residual moisture, prevent the microcapsules from being affected by the humid environment during storage, and ensure their long-term stability.

[0011] Therefore, through microencapsulation technology, the antibacterial agent can be gradually released during use, providing a sustained antibacterial effect, significantly extending the shelf life of the product, and effectively protecting the antibacterial agent to prevent it from becoming ineffective during storage and use, thereby improving the stability and effectiveness of the product, allowing the antibacterial agent to be evenly distributed in the preparation, ensuring that it covers every corner of the oral cavity during use, providing comprehensive protection, which not only improves the functionality of the product, but also reduces irritation to the oral cavity, making the user more comfortable when using it and suitable for long-term use.

[0012] In one technical solution of the present invention, in S120, the surfactant includes a cationic surfactant or an anionic surfactant; wherein the cationic surfactant includes one or more of Na-lauroyl-L-arginine sodium hydrochloride and chlorhexidine acetate; the anionic surfactant includes one or more of sodium lauroyl sarcosinate and sodium lauryl sulfate.

[0013] Compared with the prior art, the technical effect achieved by adopting this technical solution is that the cationic surfactant or the anionic surfactant can be selected according to specific needs. When the viscosity μ of the core material emulsion is greater than 1, the emulsion is too viscous and difficult to cover evenly in the oral cavity. The cationic surfactant makes the hydroxyethyl cellulose have the properties of a polyelectrolyte through its side chain groups, enhances the electrostatic repulsion, and expands the polymer chain, thereby reducing the viscosity of the emulsion and increasing the fluidity. This process ensures that the emulsion can cover the oral surface more evenly when used; at the same time, the cationic surfactant has a strong antibacterial property. By changing the charge of the bacterial cell membrane, it can effectively inhibit pathogenic microorganisms in the oral cavity, reduce plaque formation, and help maintain oral hygiene; when the fluidity μ of the core material emulsion is less than 0.7, the emulsion viscosity is too low, and the anionic surfactant can form a mixed micelle structure through the interaction between its hydrophobic side chains to increase the viscosity of the emulsion. This effect enables the emulsion to better adhere to the oral surface when used and cover more evenly. At the same time, the anionic surfactant performs better in removing dirt and plaque on the tooth surface and inside the oral cavity. It reduces the surface tension, making it easier for the dirt to be captured and removed by the emulsion, thereby improving the cleaning effect of the oral cavity.

[0014] Cationic and anionic surfactants can adjust the fluidity of the core emulsion according to the specific situation, making it neither viscous nor thin, ensuring that the product can evenly and effectively cover the oral surface; at the same time, they can balance the antibacterial and cleaning properties. By selecting suitable surfactants, the best balance can be achieved between the antibacterial and cleaning effects, thereby improving the overall performance of the product and user experience.

[0015] In one technical solution of the present invention, in S110, the mass ratio of porous cyclodextrin to deionized water is (3-5):1; and / or in S120, the mass ratio of antibacterial agent to deionized water is (1-3):1; and / or in S120, the amount of surfactant used is 1wt.%-10wt.% of the total of antibacterial agent and deionized water; in S130, the mass ratio of wall material emulsion to core material emulsion is 1:1.

[0016] Compared with the existing technology, the technical effect achieved by adopting this technical solution is as follows: by reasonably setting the proportions of these key steps, various aspects of the microcapsule preparation process can be optimized, including the structural stability of the wall material and the core material, the concentration and dispersion of the antibacterial agent, the stability and rheology of the emulsion, and the overall structure and function of the microcapsule, which helps to improve the quality of the final product, ensure its effect and performance stability during use, and thus improve the user experience and the market competitiveness of the product.

[0017] In a technical solution of the present invention, in S130, the spray particle size of the spray treatment is 10 μm-20 μm; and / or the temperature of the drying treatment is 70° C.-90° C.

[0018] Compared with the existing technology, the technical effect achieved by adopting this technical solution is as follows: the reasonable setting of the spray particle size and the drying temperature is crucial to the preparation of microcapsules. The spray particle size of 10μm-20μm helps to form microcapsules with uniform size, smooth surface and stability, while the drying temperature of 70℃-90℃ ensures the structural integrity of the microcapsules and the activity of the antibacterial agent, while improving the production efficiency. The optimized combination of these conditions can ultimately improve the quality and performance of the microcapsule products.

[0019] In one technical solution of the present invention, the abrasive includes one or more of calcium carbonate, hydroxyapatite, silicon dioxide, and calcium hydrogen phosphate; and / or the preservative includes one or more of sodium benzoate and potassium sorbate; and / or the filler includes one or more of glucose monohydrate, D-mannitol, sorbitol, xylitol, and hydroxyethyl cellulose; and / or the enzyme includes one or more of lipase and protease; and / or the flavoring agent includes one or more of citric acid, malic acid, and flavors and fragrances; and / or other auxiliary ingredients include one or more of magnesium stearate, silicon dioxide, α-glucan oligosaccharide, and inulin.

[0020] Compared with the existing technology, the technical effect achieved by adopting this technical solution is: through the reasonable configuration of abrasives, preservatives, fillers, enzymes, flavoring agents and other auxiliary ingredients, the cleaning effect, stability, user experience and oral health function of the product can be optimized; thereby improving the overall performance of the product, meeting user needs and enhancing market competitiveness.

[0021] In a technical solution of the present invention, in S400, it further includes, after adding other auxiliary components, adjusting the pH value of the solution to 6.0-8.0 with ammonia water.

[0022] Compared with the prior art, the technical effects achieved by adopting the technical solution are as follows: since the stability of the microcapsule is affected by the pH value, a pH value within the range of 6.0-8.0 helps to maintain the structural integrity of the microcapsule wall material and prevent degradation or deformation caused by an acidic or alkaline environment, thereby improving the stability and effect of the microcapsule; and the antibacterial agent works best in a neutral or weakly alkaline environment. Adjusting the pH value to 6.0-8.0 can ensure that the activity of the antibacterial agent is fully maintained, thereby enhancing the antibacterial effect of the plaque indicator, while avoiding adverse reactions or precipitation, ensuring the uniformity and stability of the product, thereby maintaining the uniformity and fluidity of the solution; finally, a neutral or weakly alkaline pH value helps to reduce irritation to the oral mucosa, increase user comfort, and make the product easier to accept and use.

[0023] In one technical solution of the present invention, in S200, the stirring time is 15min-30min; and / or in S200, the stirring rate per minute is 1000-2000rmp; and / or in S300, the stirring time is 15min-30min; and / or in S300, the stirring rate per minute is 1500-2500rmp; and / or in S400, the stirring time is 15min-30min; and / or in S400, the stirring rate per minute is 1000-2000rmp.

[0024] Compared with the prior art, the technical effects achieved by adopting this technical solution are as follows: controlling the stirring time and stirring rate has an important influence on the mixing uniformity, the stability of the ingredients and the performance of the final product; in S200, a stirring time of 15 to 30 minutes and a stirring rate of 1000-2000 revolutions per minute are used to help the uniform dissolution and mixing of the antibacterial microcapsules and the solvent, effectively promote the dissolution of the antibacterial microcapsules, shorten the dissolution time, and avoid the presence of undissolved microcapsules remaining in the solution, thereby ensuring the uniformity of the product; in S300, a stirring time of 15 to 30 minutes and a stirring rate of 1500-2500 revolutions per minute are used to help ensure the full mixing of the dye, abrasive, filler, enzyme and flavoring agent in the solvent, ensure that all solid and liquid ingredients are fully dispersed in the solvent to form a uniform solution B, avoid local concentration differences, thereby improving the effect of the final product, and improving the effect of the final product. For example, it can enhance the visibility of dyes, improve the cleaning ability of abrasives, and ensure that the activity of enzymes is evenly distributed, thereby improving the overall performance of the product. In S400, with a stirring time of 15min-30min and a stirring rate of 1000-2000rmp, all components in solution A and solution B can be fully mixed. This rate can generate sufficient shear force to evenly distribute solutions and components of different viscosities throughout the mixture, ensuring that the various parts of the plaque indicator have consistent performance when used, avoiding inconsistent product effects due to uneven concentrations of local components, and achieving uniform mixing without being too intense, avoiding the introduction of large amounts of air or the formation of bubbles. Reducing the generation of bubbles helps to improve the stability of the plaque indicator, avoid the phenomenon of bubble rupture affecting the use effect or causing product stratification during use, and improve the final use effect and user experience of the plaque indicator.

[0025] In one technical solution of the present invention, the plaque indicator comprises the following components in mass percentage: bacterial microcapsules: 3.0%, dye: 0.08%, abrasive: 3.0%, preservative: 0.12%, filler: 36.0%, enzyme: 0.6%, flavoring agent: 2.5%, other auxiliary ingredients: 8.1% and the balance water.

[0026] Compared with the prior art, the technical effect achieved by adopting this technical solution is as follows: by adopting a certain ratio, the elements in the plaque indicator can cooperate with each other to achieve an optimal mass ratio, thereby achieving the best beneficial effect on the oral cavity.

[0027] A plaque indicator is prepared by the above preparation method, and thus includes the beneficial effects of any of the above technical solutions, which will not be described in detail here.

[0028] After adopting the technical solution of the present invention, the following technical effects can be achieved:

[0029] (1) The dye in the plaque indicator of the present application, Gardenia Blue, combines with the cell wall of dental plaque to make it appear on the tooth surface, so that the plaque area is clearly visible. The antibacterial microcapsules can slowly release the antibacterial components therein, inhibit the growth of bacteria in the oral cavity, prevent the formation of plaque, and help prevent caries, gingivitis and other oral diseases. The mixture of abrasives, flavoring agents, enzymes, preservatives, and other auxiliary ingredients obtains a final plaque indicator with uniform distribution and stability, ensuring the effectiveness and consistency of the product, thereby forming a product that can effectively visualize and inhibit oral plaque, helping users to better maintain oral hygiene;

[0030] (2) Through microencapsulation technology, the antibacterial agent can be gradually released during use, providing a sustained antibacterial effect, significantly extending the shelf life of the product, and effectively protecting the antibacterial agent to prevent it from becoming ineffective during storage and use, thereby improving the stability and effectiveness of the product, allowing the antibacterial agent to be evenly distributed in the preparation, ensuring that it covers every corner of the oral cavity during use, providing comprehensive protection, which not only improves the functionality of the product, but also reduces irritation to the oral cavity, making the user more comfortable when using it and suitable for long-term use;

[0031] (3) Cationic and anionic surfactants can adjust the fluidity of the core emulsion according to the specific situation, making it neither viscous nor thin, ensuring that the product can evenly and effectively cover the oral surface; at the same time, they can balance the antibacterial and cleaning properties. By selecting suitable surfactants, the best balance between antibacterial and cleaning effects can be achieved, thereby improving the overall performance of the product and user experience. DETAILED DESCRIPTION

[0032] In order to make the above-mentioned purposes, features and advantages of the present invention more obvious and understandable, the technical solutions in the embodiments of the present invention are described clearly and completely. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0033] Teeth cleaning and oral hygiene care are of great significance to improving physical health and have been paid more and more attention in recent years. Unhealthy teeth not only cause premature tooth loss and bring great inconvenience to life, but also cause a variety of diseases, such as heart disease, Alzheimer's disease, etc.

[0034] Traditional plaque indicators have three shortcomings: 1. They only have an indicator function through pigment staining and cannot assist in oral cleaning; 2. They are inconvenient to use and are too staining, causing the tongue and lips to be stained and difficult to clean; 3. The cleaning process is cumbersome and requires more time to brush teeth to remove pigment-stained plaque.

[0035] Therefore, the present application provides a plaque indicator and a preparation method thereof, which effectively solves the problems of excessive dyeing, difficulty in cleaning, and insufficient antibacterial effect existing in traditional products through precise formula and scientific ingredient ratio, making the detection and removal of plaque easier, while providing continuous oral protection and significantly improving the effect of oral care.

[0036] The plaque indicator comprises the following components in percentage by mass: antibacterial microcapsules: 2.0-5.0%; dye: 0.01-0.1%; abrasive: 1.0-5.0%; preservative: 0.05-0.15%; filler: 30.0-40.0%; enzyme: 0.1-1.0%; flavoring agent: 0.2-3%; other auxiliary ingredients: 5.0-10.0%; solvent: balance;

[0037] Preferably, the dye includes gardenia blue, which is a natural ingredient and is commonly used in cakes. A small amount of pigment content can ensure that other organs in the oral cavity are not over-stained while staining dental plaque, and gardenia blue can combine with the dental plaque cell wall to make it appear on the tooth surface, so that the plaque area is clearly visible, further guiding users to clean their teeth more effectively, especially the hard-to-see parts are easy for users to find and remove, thereby improving the effectiveness of users' brushing and other oral cleaning methods;

[0038] The antibacterial components of the antibacterial microcapsules are one or more of tea tree oil and honeysuckle extract; the antibacterial microcapsules can slowly release the antibacterial components therein, such as tea tree oil and honeysuckle extract, which have natural antibacterial effects. These components can inhibit the growth of bacteria in the oral cavity, prevent the formation of plaque, and help prevent caries, gingivitis and other oral diseases. At the same time, the microencapsulation technology ensures the stability and long-term effectiveness of the antibacterial components, so that the plaque indicator can continuously inhibit the growth of plaque;

[0039] The abrasive includes one or more of calcium carbonate, hydroxyapatite, silicon dioxide, and calcium hydrogen phosphate. The abrasive improves the plaque removal effect and enhances the cleaning effect through physical friction. Combined with the dye, the user can remove dental plaque more accurately.

[0040] The preservative includes one or more of sodium benzoate and potassium sorbate. The preservative can prevent the product from being contaminated by microorganisms during storage and use, thereby ensuring the stability and safety of the plaque indicator and extending the service life of the product.

[0041] The filler includes one or more of glucose monohydrate, D-mannitol, sorbitol, and xylitol; the filler is used as a matrix material to provide volume and viscosity for the entire product, making it easy to use without affecting the health of teeth and oral cavity;

[0042] The enzyme includes one or more of lipase and protease; protease and lipase can soften the colored dental plaque, and with the addition of abrasives, the dental plaque can be better separated from the teeth, providing convenience for subsequent cleaning;

[0043] Flavoring agents include one or more of citric acid, malic acid, and flavors and fragrances; flavoring agents can improve the taste of the product, increase user acceptance and usage experience, and prevent bad taste from affecting usage;

[0044] Other auxiliary ingredients include one or more of magnesium stearate, silicon dioxide, α-glucan oligosaccharide, and inulin. Other auxiliary ingredients can improve the physical properties of the product, such as fluidity and spreadability, and ensure the convenience and stability of the product in actual use;

[0045] Furthermore, the mass ratio of inulin, medical purified water, and α-glucan oligosaccharide is (60-80):25:(1-14); inulin, medical purified water, and α-glucan oligosaccharide can constitute prebiotic components in a certain proportion, which can serve as exogenous supplementary active substances and nutrients for probiotics, can be absorbed by beneficial bacteria in the oral cavity, but will not be used by harmful bacteria, thereby competitively inhibiting pathogens, thereby achieving the effect of protecting, repairing and strengthening the oral environment.

[0046] The solvent acts as a medium to dissolve and mix the components so that they are evenly distributed throughout the product, ensuring consistent results each time it is used.

[0047] Furthermore, the preparation method of the plaque indicator comprises:

[0048] S100, preparing antibacterial microcapsules;

[0049] Preferably, in S110, porous cyclodextrin is first added to deionized water and stirred evenly to obtain a wall material emulsion; porous cyclodextrin has a unique structure and can encapsulate and protect active ingredients, and its porosity provides more surface area, so that it can effectively encapsulate the antibacterial agent to prevent the antibacterial agent from being oxidized or degraded during storage and use, thereby achieving a slow release of the active ingredient, which is beneficial to continuously inhibiting the growth of bacteria in the oral cavity; deionized water is used as a solvent to ensure that the porous cyclodextrin is evenly dispersed in the solution to form a stable wall material emulsion;

[0050] Furthermore, the ratio of porous cyclodextrin to deionized water is set to (3-5):1, which is helpful to form a wall material emulsion with good structural stability. A higher ratio of porous cyclodextrin ensures a sufficient amount of wall material, so that a strong and stable microcapsule wall can be formed in the subsequent microencapsulation process, thereby better wrapping and protecting the antibacterial agent in the core material to prevent it from being affected by the external environment during the preparation or storage process. In addition, porous cyclodextrin has a certain pore structure, which helps to achieve the slow release of the antibacterial agent, thereby extending its effective time in the product and providing a continuous antibacterial effect.

[0051] In S120, the antibacterial agent is added to deionized water, and then a surfactant is added, and the mixture is uniformly mixed to obtain a core material emulsion; the antibacterial agent is the core component of the microcapsule, and its main function is to inhibit and kill pathogenic bacteria in the oral cavity and reduce the formation of plaque. Through microencapsulation, the antibacterial agent can be protected in the core material, reducing direct contact with the external environment, thereby maintaining its activity and stability; the surfactant can reduce the surface tension of the core material emulsion, prevent the antibacterial agent from aggregating into large particles in the water, and ensure that the antibacterial agent is evenly distributed in the solution; at the same time, it can also improve the permeability of the antibacterial agent when used, making it easier to diffuse to every corner of the oral cavity and enhancing the antibacterial effect;

[0052] Furthermore, the selection of cationic surfactants or anionic surfactants can be selected according to specific needs. When the viscosity μ of the core material emulsion is greater than 1, the emulsion is too viscous and difficult to cover evenly in the oral cavity. The cationic surfactant makes the hydroxyethyl cellulose have the properties of polyelectrolytes through its side chain groups, enhances the electrostatic repulsion, and expands the polymer chain, thereby reducing the viscosity of the emulsion and increasing the fluidity. This process ensures that the emulsion can cover the oral surface more evenly when used; at the same time, the cationic surfactant has strong antibacterial properties. By changing the charge of the bacterial cell membrane, it can effectively inhibit pathogenic microorganisms in the oral cavity, reduce plaque formation, and help maintain oral hygiene; when the fluidity μ of the core material emulsion is less than 0.7, the emulsion viscosity is too low, and the anionic surfactant can form a mixed micelle structure through the interaction between its hydrophobic side chains to increase the viscosity of the emulsion. This effect allows the emulsion to better adhere to the oral surface when used, and the coverage is more uniform. At the same time, the anionic surfactant performs better in removing dirt and plaque on the tooth surface and inside the oral cavity. It reduces the surface tension, making it easier for the dirt to be captured and removed by the emulsion, thereby improving the cleaning effect of the oral cavity.

[0053] Furthermore, the mass ratio of the antibacterial agent to deionized water (1-3): 1 is helpful to adjust the concentration of the antibacterial agent in the core material emulsion, avoid precipitation or crystallization of the antibacterial agent due to excessive concentration, and thus improve the stability of the emulsion during the preparation process; the amount of the surfactant is set to 1wt.%-10wt.% of the total amount of the antibacterial agent and deionized water. Within this ratio range, the surfactant can also adjust the rheological properties of the emulsion, such as viscosity and fluidity, so that the emulsion is easier to operate and control in subsequent mixing, spraying, drying and other steps, ensuring the uniformity and consistency of the microcapsules;

[0054] In S130, the wall material emulsion and the core material emulsion are evenly mixed and then sprayed and dried in sequence to obtain antibacterial microcapsules; by mixing the wall material emulsion and the core material emulsion, it is ensured that the antibacterial agent is evenly wrapped in the wall material formed by the porous cyclodextrin, which helps to form stable microcapsules and reduce direct exposure of the antibacterial agent, thereby preventing its premature release or degradation; the spraying treatment causes the liquid wall material and the core material to form tiny particles, which are then dried to form stable solid microcapsules, which have good storage stability and can gradually release the antibacterial agent during use; the drying treatment helps to remove residual moisture, prevent the microcapsules from being affected by the humid environment during storage, and ensure their long-term stability.

[0055] Furthermore, the mass ratio of the wall material emulsion to the core material emulsion is 1:1, which ensures the balance of the two during the microcapsule formation process, helps to form microcapsules with stable structure and moderate strength, and will not affect the release of the antibacterial agent due to the wall material being too thick, nor will the microcapsules be easily broken due to the wall material being too thin, thereby providing a consistent antibacterial effect during use;

[0056] Furthermore, setting the spray particle size to 10μm-20μm helps ensure that the particle size of the microcapsules is within a controllable range. Smaller spray particle sizes can produce microcapsules of uniform size, thereby ensuring that each microcapsule has a similar wall thickness and core material encapsulation amount, which is very important for the uniformity and stability of the product. At the same time, it can form a smoother microcapsule surface, which helps to improve the stability of the microcapsules, reduce surface defects and holes, and prevent the antibacterial agent from being released too quickly or the external environment from affecting the core material. In addition, a smaller particle size means a larger surface area to volume ratio, thereby improving drying efficiency, reducing drying time, and avoiding excessive heating of the core and wall materials. The drying temperature is set at 70℃-90℃, which can effectively balance the drying speed and the stability of the antibacterial agent. The lower temperature range can prevent the antibacterial agent from being degraded due to overheating, thereby maintaining its activity and effectiveness.

[0057] S200, mixing the antibacterial microcapsules with 1 / 5-2 / 5 of a solvent, stirring evenly and heating to dissolve at 40°C-60°C to obtain a solution A;

[0058] Preferably, by mixing the antibacterial microcapsules with part of the solvent and stirring them, the microcapsules can be evenly dispersed in the solution to avoid the formation of lumps or precipitation, thereby ensuring the consistency of the antibacterial effect, improving the antibacterial properties of the entire product, and ensuring that all parts of the oral cavity can be effectively protected by antibacterial protection; heating the solution within a temperature range of 40°C-60°C can accelerate the dissolution of the antibacterial microcapsules and promote the release of the active ingredients therein into the solution more quickly. This heating treatment helps to activate the antibacterial ingredients in a short time so that they can quickly take effect, which can not only maintain the structural integrity of the microcapsules and prevent the degradation of the ingredients caused by excessive heating, but also ensure the antibacterial effect. The ingredients are released more fully in the solution, thereby improving the immediate effect and stability of the product; by controlling the proportion of the solvent and the heating temperature, the dissolution rate of the microcapsules can be accurately adjusted, thereby controlling the release rate of the antibacterial ingredients, ensuring that the antibacterial ingredients in the entire preparation are neither released too quickly, resulting in loss of long-term effects, nor released too slowly, affecting the immediate effect, thereby achieving the best antibacterial effect and product stability; by mixing the antibacterial microcapsules with part of the solvent in step S200 and heating and dissolving them at a suitable temperature, the uniform distribution and proper dissolution of the antibacterial microcapsules can be ensured, optimizing the release of the antibacterial ingredients, while ensuring the stability of the product. This operation not only helps to improve the immediate effect and durability of the product, but also enhances the user experience.

[0059] Furthermore, in S200, a stirring time of 15 to 30 minutes and a stirring rate of 1000-2000 revolutions per minute are used to facilitate uniform dissolution and mixing of the antibacterial microcapsules and the solvent, effectively promoting the dissolution of the antibacterial microcapsules, shortening the dissolution time, and avoiding the presence of undissolved microcapsules remaining in the solution, thereby ensuring the uniformity of the product.

[0060] S300, adding a dye, a friction agent, a filler, an enzyme, and a flavoring agent to the remaining solvent, stirring evenly, to obtain a solution B;

[0061] Preferably, the dye, abrasive, filler, enzyme, and flavoring agent are added to the solvent one by one and stirred, which can ensure that each ingredient is evenly dispersed in the solution, avoiding the phenomenon of ingredient concentration or local accumulation, thereby ensuring that each part of the solution can play the expected function during use, such as dyeing, cleaning, taste adjustment, etc., and the plaque indicator can evenly dye the plaque on the surface of the teeth, so that the user can clearly identify the plaque area on the teeth, improve the effect of oral cleaning, and avoid inconsistent dyeing effect caused by uneven distribution of the dye in the solution, thereby improving the overall performance of the plaque indicator and user experience.

[0062] Furthermore, in S300, a stirring time of 15 to 30 minutes and a stirring rate of 1500-2500 rpm help ensure that the colorant, abrasive, filler, enzyme and flavoring agent are fully mixed in the solvent, and that all solid and liquid components are fully dispersed in the solvent to form a uniform solution B, thereby avoiding local concentration differences and improving the effect of the final product, such as enhancing the visibility of the colorant, improving the cleaning ability of the abrasive, and ensuring that the activity of the enzyme is evenly distributed, thereby improving the overall performance of the product.

[0063] S400, after mixing and stirring solution A and solution B evenly, adding other auxiliary components to obtain a plaque indicator.

[0064] Preferably, by mixing and stirring solution A and solution B and adding other auxiliary ingredients, it is possible to ensure uniform distribution of product ingredients, optimize antibacterial and cleaning effects, improve product stability and user experience, and achieve a multifunctional comprehensive effect.

[0065] Furthermore, in S400, at a stirring time of 15min-30min and a stirring rate of 1000-2000rmp, all components in solution A and solution B can be fully mixed. This rate can generate sufficient shear force to evenly distribute solutions and components of different viscosities throughout the mixture, ensuring that the various parts of the plaque indicator have consistent performance during use, avoiding inconsistent product effects due to uneven concentrations of local components, and achieving uniform mixing without being too intense, avoiding the introduction of large amounts of air or the formation of bubbles. Reducing the generation of bubbles helps to improve the stability of the plaque indicator, avoid the phenomenon of bubble rupture affecting the use effect or causing product stratification during use, and improve the final use effect and user experience of the plaque indicator.

[0066] In addition, S400 also includes adjusting the pH value of the solution to 6.0-8.0 with ammonia water after adding other auxiliary ingredients. Since the stability of microcapsules is affected by the pH value, a pH value within the range of 6.0-8.0 helps to maintain the structural integrity of the microcapsule wall material and prevent degradation or deformation caused by an acidic or alkaline environment, thereby improving the stability and effect of the microcapsules; and the antibacterial agent works best in a neutral or weakly alkaline environment. Adjusting the pH value to 6.0-8.0 can ensure that the activity of the antibacterial agent is fully maintained, thereby enhancing the antibacterial effect of the plaque indicator, while avoiding adverse reactions or precipitation, ensuring the uniformity and stability of the product, thereby maintaining the uniformity and fluidity of the solution; finally, a neutral or weakly alkaline pH value helps to reduce irritation to the oral mucosa, increase user comfort, and make the product easier to accept and use.

[0067] [Example 1]

[0068] The present embodiment provides a plaque indicator and a preparation method thereof, wherein the following components are prepared by mass percentage: antibacterial microcapsules: 3.0%, gardenia blue: 0.08%, silicon dioxide: 3.0%, potassium sorbate: 0.12%, glucose monohydrate: 35%, hydroxyethyl cellulose: 1.0%, protease: 0.3%, lipase: 0.3%, citric acid: 1.0%, blackcurrant flavor: 1.5%, magnesium stearate: 2.0%, α-glucan oligosaccharide: 6%, inulin: 0.1% and the balance of deionized water, and the antibacterial component in the antibacterial microcapsules is tea tree oil;

[0069] S110, mixing porous cyclodextrin and deionized water in a mass ratio of 4:1, stirring evenly, to obtain a wall material emulsion;

[0070] S120, tea tree oil and deionized water are mixed in a mass ratio of 2:1, and 5 wt.% of Na-lauroyl-L-arginine hydrochloride is added according to the total amount of the antibacterial agent and the deionized water, and the mixture is mixed evenly to obtain a core material emulsion;

[0071] S130, after uniformly mixing the wall material emulsion and the core material emulsion in a mass ratio of 1:1, sequentially performing a spraying treatment with a spray particle size of 15 μm and a drying treatment at a temperature of 80° C. to obtain antibacterial microcapsules;

[0072] S200, mixing the antibacterial microcapsules with 1 / 5 deionized water, stirring for 20 minutes at a stirring rate of 1500 rpm, stirring evenly, and heating at 50° C. to dissolve, to obtain solution A;

[0073] S300, adding gardenia blue, silicon dioxide, glucose monohydrate, hydroxyethyl cellulose, protease, lipase, citric acid, and blackcurrant essence to the remaining solvent, stirring for 20 minutes at a stirring rate of 2000 rpm to obtain a solution B;

[0074] S400, mixing solution A and solution B, adding magnesium stearate, α-glucan oligosaccharide, and inulin, stirring for 20 minutes at a stirring rate of 1500 rpm, and adjusting the pH value of the solution to 7.0 with ammonia water to obtain a plaque indicator.

[0075] [Example 2]

[0076] The present embodiment provides a plaque indicator and a preparation method thereof, wherein the following components are prepared by mass percentage: antibacterial microcapsules: 2.0%, gardenia blue: 0.01%, calcium carbonate: 1.0%, sodium benzoate: 0.05%, D-mannitol: 30%, hydroxyethyl cellulose: 0.5%, protease: 0.1%, lipase: 0.1%, malic acid 0.1%, grape flavor: 0.1%, magnesium stearate: 2.0%, α-glucan oligosaccharide: 3.0%, inulin: 0.05% and the balance of deionized water, and the antibacterial component in the antibacterial microcapsules is honeysuckle extract;

[0077] S110, mixing porous cyclodextrin and deionized water in a mass ratio of 3:1, stirring evenly, to obtain a wall material emulsion;

[0078] S120, mixing the honeysuckle extract and deionized water in a mass ratio of 1:1, and then adding 1wt.% of sodium lauroyl sarcosinate based on the total amount of the antibacterial agent and the deionized water, and mixing them evenly to obtain a core material emulsion;

[0079] S130, after uniformly mixing the wall material emulsion and the core material emulsion in a mass ratio of 1:1, sequentially performing a spraying treatment with a spray particle size of 10 μm and a drying treatment at a temperature of 70° C. to obtain antibacterial microcapsules;

[0080] S200, mixing the antibacterial microcapsules with 1 / 5 deionized water, stirring for 10 minutes at a stirring rate of 1000 rpm, stirring evenly, and heating at 40° C. to dissolve, to obtain solution A;

[0081] S300, adding gardenia blue, calcium carbonate, D-mannitol, hydroxyethyl cellulose, protease, lipase, malic acid, and grape essence to the remaining solvent, stirring for 10 minutes at a stirring rate of 1500 rpm to obtain a solution B;

[0082] S400, mixing solution A and solution B, adding magnesium stearate, α-glucan oligosaccharide, and inulin, stirring for 10 minutes at a stirring rate of 1000 rpm, and adjusting the pH value of the solution to 6.0 with ammonia water to obtain a plaque indicator.

[0083] [Example 3]

[0084] The present embodiment provides a plaque indicator and a preparation method thereof, wherein the following components are prepared by mass percentage: antibacterial microcapsules: 5.0%, gardenia blue: 0.1%, hydroxyapatite: 5.0%, potassium sorbate: 0.15%, sorbitol: 40%, protease: 0.5%, lipase: 0.5%, citric acid: 1.5%, blackcurrant essence: 1.5%, magnesium stearate: 4.0% and the balance of deionized water, and the antibacterial component in the antibacterial microcapsules is tea tree oil;

[0085] S110, mixing porous cyclodextrin and deionized water in a mass ratio of 5:1, stirring evenly, to obtain a wall material emulsion;

[0086] S120, tea tree oil and deionized water are mixed in a mass ratio of 3:1, and 10 wt.% of chlorhexidine acetate is added according to the total amount of the antibacterial agent and the deionized water, and the mixture is mixed evenly to obtain a core material emulsion;

[0087] S130, after uniformly mixing the wall material emulsion and the core material emulsion in a mass ratio of 1:1, sequentially performing a spraying treatment with a spray particle size of 20 μm and a drying treatment at a temperature of 90° C. to obtain antibacterial microcapsules;

[0088] S200, mixing the antibacterial microcapsules with 2 / 5 deionized water, stirring for 30 minutes at a stirring rate of 2000 rpm, stirring evenly, and heating at 60° C. to dissolve, to obtain solution A;

[0089] S300, adding gardenia blue, hydroxyapatite, sorbitol, protease, lipase, citric acid, and blackcurrant essence to the remaining solvent, stirring for 30 minutes at a stirring rate of 2500 rpm to obtain a solution B;

[0090] S400, mixing solution A and solution B, adding magnesium stearate, stirring for 30 minutes at a stirring rate of 2000 rpm, and adjusting the pH value of the solution to 8.0 with ammonia water to obtain a plaque indicator.

[0091] [Comparative Example 1]

[0092] This comparative example provides a plaque indicator and a preparation method thereof, wherein the following components are prepared by mass percentage: Brilliant Blue FCF: 0.1%, hydroxyapatite: 5.0%, potassium sorbate: 0.15%, sorbitol: 40%, protease: 0.5%, lipase: 0.5%, magnesium stearate: 4.0% and the balance of deionized water;

[0093] S300, adding gardenia blue, hydroxyapatite, sorbitol, hydroxyethyl cellulose, protease, lipase, citric acid, and blackcurrant essence to the remaining solvent, stirring for 30 minutes at a stirring rate of 2500 rpm to obtain a solution B;

[0094] S400, adding magnesium stearate, α-glucan oligosaccharide and inulin to solution B, stirring for 30 minutes at a stirring rate of 2000 rpm, and adjusting the pH value of the solution to 8.0 with ammonia water to obtain a plaque indicator.

[0095] [Comparative Example 2]

[0096] The comparative example provides a plaque indicator and a preparation method thereof, wherein the following components are prepared by mass percentage: cymene: 5.0%, brilliant blue FCF: 0.1%, hydroxyapatite: 5.0%, potassium sorbate: 0.15%, sorbitol: 40%, protease: 0.5%, lipase: 0.5%, citric acid: 1.5%, black currant flavor: 1.5%, magnesium stearate: 4.0% and the balance of deionized water, and the antibacterial component in the antibacterial microcapsule is tea tree oil;

[0097] S300, adding cymene, gardenia blue, hydroxyapatite, sorbitol, hydroxyethyl cellulose, protease, lipase, citric acid, and blackcurrant essence to the remaining solvent, stirring for 30 minutes at a stirring rate of 2500 rpm to obtain a solution B;

[0098] S400, adding magnesium stearate, α-glucan oligosaccharide and inulin to solution B, stirring for 30 minutes at a stirring rate of 2000 rpm, and adjusting the pH value of the solution to 8.0 with ammonia water to obtain a plaque indicator.

[0099] In order to verify whether the plaque indicator of the present invention achieves the expected effect, the present invention was tested for performance, and the results are as follows:

[0100] (1) Antibacterial effect

[0101] The harmful bacteria that cause dental caries and periodontitis in the oral cavity mainly include lactic acid streptococci, transglycosyl Streptococcus, and spirochetes. The beneficial bacteria take salivarius as an example. This experiment tests the above bacteria and records the test results. The results are as follows:

[0102] Table 1

[0103] project Streptococcus lactis Streptococcus transaglycosinus Spirochete Streptococcus salivarius Example 1 100％ 100％ 100％ 3.9％ Example 2 100％ 100％ 100％ 4.5％ Example 3 100％ 100％ 100％ 37.9％ Comparative Example 1 7.2％ 8.4％ 9.9％ 43.9％ Comparative Example 2 59.7％ 57.8％ 59.4％ 39.7％

[0104] (2) Sensory evaluation

[0105] The plaque indicators of Examples 1-3 and Comparative Examples 1-2 were evaluated with 10 healthy volunteers as test subjects. The evaluation items were: plaque indication effect, taste, and plaque inhibition effect. 0 points indicated that the effect was basically ineffective / very unsatisfactory, and 5 points indicated that the effect was significant / very satisfactory. The results are shown in Table 2:

[0106] Table 2

[0107]

[0108]

[0109] As can be seen from the above table, the present application can effectively inhibit lactic acid streptococci, transglycosyl streptococci, and spirochetes. It also has the effect of promoting probiotics by adding a certain amount of α-glucan oligosaccharides and inulin. The user evaluation of Examples 1-3 of the present application is much higher than that of Comparative Examples 1-2. The natural pigment gardenia blue used in the present application can effectively dye dental plaque, and the ingredients are pure and natural, which can ensure that other organs in the oral cavity are not over-dyed while dyeing dental plaque. By adding flavoring agents, the taste of use is improved, and the antibacterial microcapsules also solve the problem of insufficient traditional antibacterial effect.

[0110] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A method for preparing a plaque indicator, characterized in that: The plaque indicator comprises the following components in percentage by mass: Antibacterial microcapsules: 2.0-5.0%; Dye: 0.01-0.1%; Friction agent: 1.0-5.0%; Preservatives: 0.05-0.15%; Filler: 30.0-40.0%; Enzyme: 0.1-1.0%; Flavoring agent: 0.2-3%; Other auxiliary ingredients: 5.0-10.0%; Solvent: balance; Wherein, the antibacterial component in the antibacterial microcapsule is one or more of tea tree oil and honeysuckle extract; The dye comprises gardenia blue; The preparation method of the plaque indicator comprises: S100, preparing the antibacterial microcapsules; S200, mixing the antibacterial microcapsules with 1 / 5-2 / 5 of the solvent, stirring evenly and heating to dissolve at 40° C.-60° C. to obtain solution A; S300, adding the dye, abrasive, filler, enzyme, and flavoring agent to the remaining solvent, stirring evenly, to obtain solution B; S400, after the solution A and the solution B are mixed and stirred evenly, the other auxiliary components are added to obtain the plaque indicator.

2. The preparation method according to claim 1, characterized in that: The preparation of antibacterial microcapsules in S100 specifically includes: S110, adding porous cyclodextrin into deionized water and stirring evenly to obtain a wall material emulsion; S120, adding an antibacterial agent to deionized water, and then adding a surfactant, and mixing them evenly to obtain a core material emulsion; S130, mixing the wall material emulsion and the core material emulsion uniformly, and then performing spraying treatment and drying treatment in sequence to obtain the antibacterial microcapsules.

3. The preparation method according to claim 2, characterized in that: In S120, the surfactant includes a cationic surfactant or an anionic surfactant; Wherein, the cationic surfactant includes one or more of Na-lauroyl-L-arginine sodium hydrochloride and chlorhexidine acetate; The anionic surfactant includes one or more of sodium lauroyl sarcosinate and sodium lauryl sulfate.

4. A method for preparing a plaque indicator, characterized in that: In the S110, the mass ratio of the porous cyclodextrin to the deionized water is (3-5):1; and / or In the S120, the mass ratio of the antibacterial agent to the deionized water is (1-3):1; and / or In the S120, the amount of the surfactant is 1wt.%-10wt.% of the total amount of the antibacterial agent and the deionized water; In the S130, the mass ratio of the wall material emulsion to the core material emulsion is 1:

1.

5. The preparation method according to claim 2, characterized in that: In the S130, The spray particle size of the spray treatment is 10 μm-20 μm; and / or The temperature of the drying treatment is 70°C-90°C.

6. The preparation method according to claim 1, characterized in that: The friction agent includes one or more of calcium carbonate, hydroxyapatite, silicon dioxide, and calcium hydrogen phosphate; and / or The preservative includes one or more of sodium benzoate and potassium sorbate; and / or The filler includes one or more of glucose monohydrate, D-mannitol, sorbitol, xylitol, and hydroxyethyl cellulose; and / or The enzyme comprises one or more of lipase and protease; and / or Flavoring agents include one or more of citric acid, malic acid, flavors and spices; and / or Other auxiliary ingredients include one or more of magnesium stearate, silicon dioxide, α-glucan oligosaccharide, and inulin.

7. The preparation method according to claim 1, characterized in that: In S400, it also includes, after adding the other auxiliary components, adjusting the pH value of the solution to 6.0-8.0 with ammonia water.

8. The preparation method according to claim 1, characterized in that: In S200, the stirring time is 15 min-30 min; and / or In S200, the stirring rate per minute is 1000-2000 rpm; and / or In the S300, the stirring time is 15 min-30 min; and / or In the S300, the stirring rate per minute is 1500-2500 rpm; and / or In the S400, the stirring time is 15 min-30 min; and / or In the S400, the stirring rate per minute is 1000-2000 rpm.

9. The preparation method according to claim 1, characterized in that: The plaque indicator comprises the following components in percentage by mass: Antibacterial microcapsules: 3.0%, coloring agent: 0.08%, abrasive: 3.0%, preservative: 0.12%, filler: 36.0%, enzyme: 0.6%, flavoring agent: 2.5%, other auxiliary ingredients: 8.1% and the balance water.

10. A plaque indicator, characterized in that The plaque indicator is prepared by the preparation method according to any one of claims 1 to 9.

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