Hydrogen nanobubble organ storage protection liquid storage bag

Abstract

The invention relates to the technical field of biomedicine, in particular to a hydrogen nanobubble organ storage protection liquid storage bag, a packaging material of the storage bag is high-density polypropylene or ethylene glycol terephthalate, besides organ storage protection liquid, the storage bag further contains gas with the volume accounting for 0.1%-20% of the internal volume of the storage bag, and the hydrogen partial pressure is larger than or equal to 0.02 Mpa. Hydrogen molecules enter the organ storage protection liquid through the processes of free diffusion, convective diffusion and the like, a large number of hydrogen-containing nano bubbles are formed, a very effective quenching effect on a large number of free radicals generated by organs is achieved, then the organs are better protected, the hydrogen-containing nano bubbles can be used for storage before transplantation of in-vitro kidneys, livers, pancreas, hearts and lungs, the effective storage time is prolonged, and the survival rate is increased. The transplanting success rate is improved.

Description

Technical Field

[0001] The invention relates to the technical field of biomedicine, in particular to a hydrogen nano bubble organ storage protective liquid storage bag. Background Art

[0002] Organ storage is crucial to the organ transplantation process. The biggest problem in the organ storage process is the generation of a large number of free radicals caused by ischemia and reperfusion, which in turn causes multiple oxidative damages to the stored organs. Existing organ storage protection fluids include UW fluid and HTK fluid, etc. The above-mentioned organ storage protection fluids are mainly made of viscous substances, buffer salts, etc., with the main purpose of reducing the damage caused by ischemia and hypoxia to the organs.

[0003] However, the above-mentioned organ storage protection liquid has little effect on quenching free radicals, and is almost powerless against various oxidative damages caused by free radicals. In view of this, the present invention provides a hydrogen nano bubble organ storage protection liquid storage bag, specifically a hydrogen nano bubble organ storage protection liquid storage bag, whose packaging material is high-density polypropylene or polyethylene terephthalate. In addition to the organ storage protection liquid, the storage bag also contains a gas with a volume accounting for 0.1%-20% of the internal volume of the storage bag and a hydrogen partial pressure ≥0.02Mpa. Hydrogen molecules enter the organ storage protection liquid through processes such as free diffusion and convection diffusion to form a large number of hydrogen-containing nano bubbles, which have a very effective quenching effect on a large number of free radicals generated by the organ, thereby better protecting the organ. The hydrogen nano bubbles can be used for storage before in vitro kidney, liver, pancreas, heart and lung transplantation, prolong the effective storage time, and improve the success rate of transplantation. Summary of the invention

[0004] The purpose of the present invention is to provide a hydrogen nanobubble organ storage protection liquid storage bag to solve the problems raised in the above background technology.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] A hydrogen nano bubble organ storage protective liquid storage bag, characterized in that its packaging material is high-density polypropylene or polyethylene terephthalate, and the hydrogen permeability coefficient of the material is less than 1x10 -10 mol / s / m / Pa 1 / 2 ;

[0007] In addition to the organ storage protection solution, the storage bag also contains a gas whose volume accounts for 0.1%-20% of the internal volume of the storage bag, and the hydrogen partial pressure of the gas is ≥0.02Mpa, and more preferably, the hydrogen partial pressure of the gas is ≥0.1Mpa.

[0008] Compared with the prior art, the invention has the following beneficial effects: the storage bag is made of medical packaging material with ultra-low hydrogen permeability coefficient, and is filled with a mixed gas containing hydrogen; since the storage protection solution contains water for injection and viscous sugar substances, it has a certain solubility for hydrogen. After being packaged in the storage bag, hydrogen molecules enter the organ storage protection solution through processes such as free diffusion and convection diffusion, forming a large number of hydrogen-containing nanobubbles; since the nanobubbles are small in size and the organ storage protection solution has a high viscosity, the hydrogen-containing nanobubbles can exist in the form of Brownian motion for a long time. When the above-mentioned organ storage protection solution containing hydrogen nanobubbles is used, the existence time of the hydrogen-containing nanobubbles can reach several days or even months, which is much longer than the organ storage time. A large number of hydrogen nanobubbles have a very effective quenching effect on a large number of free radicals generated by the organ, thereby better protecting the organ, and can be used for the storage of ex vivo kidneys, livers, pancreases, hearts and lungs before transplantation, prolonging the effective storage time and improving the transplantation success rate. BRIEF DESCRIPTION OF THE DRAWINGS

[0009] Figure 1 It is an overall schematic diagram of the present invention.

[0010] The serial numbers in the figure are: 1 is the storage bag, 2 is the organ storage protection solution, and 3 is the mixed gas. DETAILED DESCRIPTION

[0011] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0012] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0013] In the description of this patent, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", and "set" should be understood in a broad sense. For example, it can be fixedly connected or set, or it can be detachably connected or set, or connected or set in one piece. For ordinary technicians in this field, the specific meanings of the above terms in this patent can be understood according to specific circumstances. In the description of the present invention, the meaning of "multiple" is two or more, unless otherwise clearly and specifically limited.

[0014] See also Figure 1 As shown, an embodiment of a hydrogen nano bubble organ storage protection liquid storage bag provided by the present invention is as follows:

[0015] The hydrogen permeability coefficient is 1×10 -12 mol / s / m / Pa 1 / 2 The organ storage protection liquid storage bag made of medical PET material contains 2L of organ storage protection liquid 2 and contains a mixed gas with a pressure of 0.12MPa, a hydrogen partial pressure of 90%, an oxygen partial pressure of 8%, and a nitrogen partial pressure of 2%. Since the storage protection liquid contains injection water and viscous sugar substances, it has a certain solubility for hydrogen. When packed into the storage bag, hydrogen molecules enter the organ storage protection liquid through free diffusion and convection diffusion, forming a large number of hydrogen-containing nanobubbles in the organ storage protection liquid.

[0016] Compared with the prior art, the invention has the following beneficial effects: the storage bag adopts a hydrogen nano bubble organ storage protection solution, the packaging material of which is high-density polypropylene or polyethylene terephthalate. In addition to the organ storage protection solution, the storage bag also contains a gas whose volume accounts for 0.1%-20% of the internal volume of the storage bag and whose hydrogen partial pressure is ≥0.02Mpa. Hydrogen molecules enter the organ storage protection solution through processes such as free diffusion and convection diffusion to form a large number of hydrogen-containing nano bubbles. Due to the small size of the nano bubbles and the high viscosity of the organ storage protection solution, the hydrogen-containing nano bubbles can exist in the form of Brownian motion for a long time. When the above-mentioned organ storage protection solution containing hydrogen nano bubbles is used, the existence time of the hydrogen-containing nano bubbles can reach several days or even several months, which is much longer than the organ storage time. A large number of hydrogen nano bubbles have a very effective quenching effect on a large number of free radicals generated by the organ, thereby better protecting the organ. The invention can be used for the storage of isolated kidneys, livers, pancreases, hearts and lungs before transplantation, prolonging the effective storage time and improving the transplantation success rate.

[0017] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments. The above embodiments and descriptions are only preferred examples of the present invention and are not intended to limit the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A hydrogen nano bubble organ storage protection liquid storage bag, characterized in that: The packaging material is high-density polypropylene or polyethylene terephthalate, and the hydrogen permeability coefficient of the material is <1x10 -12 mol / s / m / Pa 1 / 2 ; In addition to the organ storage protection solution, the storage bag also contains a gas whose volume accounts for 0.1%-20% of the internal volume of the storage bag, and the hydrogen partial pressure of the gas is ≥0.02Mpa, and more preferably, the hydrogen partial pressure of the gas is ≥0.1Mpa.

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