Human intestinal capsule for detecting occult blood and occult blood detection method

Abstract

The invention discloses a human intestinal capsule for detecting occult blood and an occult blood detection method. The human intestinal capsule comprises a shell and a circuit board located in the shell. The shell comprises an inner layer and an outer layer, the outer layer is made of a dual-network hydrogel-guaiacol compound, and an electrode is arranged in the outer layer; the circuit board is provided with a power supply unit, a single-chip microcomputer and a wireless transmitting module, the power supply unit is connected with the single-chip microcomputer and the wireless transmitting module, and the single-chip microcomputer is connected with the electrodes and the wireless transmitting module. The occult blood condition can be monitored in real time in the intestinal tract of the human body for a long time.

Description

Technical Field

[0001] The invention belongs to the field of health monitoring and relates to a human intestinal capsule for detecting occult blood and an occult blood detection method. Background Art

[0002] In the human body, 95% of serotonin is produced mainly in the intestines. The degree of serotonin disorder is directly related to depression and intestinal diseases. Therefore, intestinal health monitoring has profound significance.

[0003] Occult blood testing is of great significance for the diagnosis of many diseases, especially in the early detection of gastrointestinal bleeding and urinary system diseases. Through occult blood testing, it is possible to understand whether the patient has gastrointestinal bleeding or urinary system bleeding, which is crucial for the early detection and treatment of related diseases.

[0004] Take Crohn's disease as an example. This is a chronic inflammation of the intestine. Some patients with mild symptoms usually take oral medications as a treatment, but after a period of time, these drugs often lose their effect, resulting in 70% of patients needing surgery to remove the damaged part of the intestine. Therefore, a method that can conveniently perform occult blood testing in the human body for a long time is needed to effectively monitor the patient's condition. Summary of the invention

[0005] The purpose of the present invention is to overcome the shortcomings of the above-mentioned prior art and provide a human intestinal capsule for detecting occult blood and an occult blood detection method, which can monitor the occult blood situation in the human intestine in real time for a long time.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions:

[0007] A human intestinal capsule for detecting occult blood, comprising a shell and a circuit board located inside the shell;

[0008] The shell includes an inner layer and an outer layer, the material of the outer layer is a double network hydrogel-guaiac complex, and electrodes are arranged in the outer layer;

[0009] A power supply unit, a single chip microcomputer and a wireless transmission module are arranged on the circuit board. The power supply unit is connected with the single chip microcomputer and the wireless transmission module. The single chip microcomputer is connected with the electrode and the wireless transmission module.

[0010] Preferably, the material of the inner layer is PET.

[0011] Preferably, an intermediate layer is provided between the inner layer and the outer layer.

[0012] Furthermore, the material of the middle layer is GELMA.

[0013] Preferably, a host computer is arranged outside the human body, and the host computer is wirelessly connected to the wireless transmission module.

[0014] Preferably, the shell is a capsule-like structure.

[0015] Preferably, the wireless transmission module adopts zigbee.

[0016] Preferably, the power supply unit model is B0505S-1WR1.

[0017] A method for detecting occult blood based on a human intestinal capsule for detecting occult blood. The double-network hydrogel in the outer layer relies on the hemoglobin in the intestine to have an activity similar to that of peroxidase, catalyzing the peroxide bond to become an electron acceptor and thereby generating an electrical signal change. A single-chip microcomputer records the electrical signal changes outside the outer shell through electrodes, and sends the collected data to the outside through a wireless transmission module, summarizes and analyzes the data, and determines whether there is occult blood.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] The shell of the present invention adopts double network hydrogel as the outer corrosion protection coating, which is not only hydrophilic and oleophobic, but also has low friction and self-repairing properties, which can reduce the influence of tissues such as intestinal folds on the work and the work on the human body; guaiac is integrated into the double network hydrogel, which not only enhances the mechanical properties of the material, but also may further affect or optimize the sensing performance through its unique chemical properties. Electrodes are embedded in the double network hydrogel, and a sensor system that can capture and transmit the changes in electrical signals generated by the catalytic reaction of ferrous erythrocytes can be constructed by embedding conductive materials into the hydrogel-guaiac complex; a single chip microcomputer is used to record the changes in electrical signals outside the shell through electrodes, and the collected data is sent to the outside through a wireless transmission module, and the data is summarized and analyzed to determine whether there is occult blood, so as to achieve real-time monitoring of occult blood in the human intestine for a long time. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 The figure is a schematic diagram of the internal structure of the human intestinal capsule for detecting occult blood according to the present invention.

[0021] Among them: 1-outer layer; 2-middle layer; 3-inner layer; 4-power supply unit; 5-zigbee sending module; 6-circuit board; 7-single chip microcomputer; 8-electrode. DETAILED DESCRIPTION

[0022] The embodiments of the present invention are described in detail below, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0023] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first" and "second" are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "multiple" is two or more, unless otherwise clearly and specifically defined.

[0024] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by technicians in the technical field to which the present invention belongs. The terms "installed", "connected", and "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, an electrical connection, or can communicate with each other; it can be directly connected or indirectly connected through an intermediate medium, and it can be the internal connection of two elements or the interaction relationship between two elements. The term "and / or" used in this article includes any and all combinations of one or more related listed items. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances. The terms used in the specification of the present invention herein are only for the purpose of describing specific embodiments and are not intended to limit the present invention.

[0025] In the present invention, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0026] The disclosure below provides many different embodiments or examples to realize different structures of the present invention. In order to simplify the disclosure of the present invention, the parts and settings of specific examples are described below. Of course, they are only examples, and the purpose is not to limit the present invention. In addition, the present invention can repeat reference numbers and / or reference letters in different examples, and this repetition is for the purpose of simplicity and clarity, which itself does not indicate the relationship between the various embodiments and / or settings discussed. In addition, the present invention provides various specific examples of processes and materials, but those of ordinary skill in the art can be aware of the application of other processes and / or the use of other materials.

[0027] like Figure 1 As shown, the human intestinal capsule for detecting occult blood of the present invention is a capsule of a size similar to a small capsule, which is propelled by intestinal peristalsis and is surrounded by an occult blood sensor made of corrosion-resistant material, including a shell and a circuit board 6 located inside the shell.

[0028] First, the outer shell of the sensor body is divided into three layers. The inner layer 3 is made of PET material. The middle layer 2 is a circle of GELMA-based biological ink stent wrapped on the inner layer 3. The outer layer 1 is a layer of double-network hydrogel covered on the middle layer 2 as a corrosion protection coating. The hydrogel network forms a highly uniform oriented structure during the stretching process. At 90% water content, its tensile strength is as high as 3MPa and the fracture energy reaches 8340Jm -2 , the strain hardening capacity can reach 47.5. In addition, the hydrogel obtains almost 100% reversible rebound ability through energy storage based on entropy reduction. The double network hydrogel is not only hydrophilic and oleophobic, but also has low friction and self-healing properties, which can reduce the impact of intestinal folds and other tissues on the work and the work on the human body.

[0029] In the present application, guaiac can be integrated into the double network hydrogel through polymerization reaction, which not only enhances the mechanical properties of the material, but also may further affect or optimize the sensing performance through its unique chemical properties. Electrodes 8 are embedded in the double network hydrogel. By embedding conductive materials into the hydrogel-guaiac complex, a sensor system that can capture and transmit the changes in electrical signals generated by the catalytic reaction of ferrohexidine can be constructed.

[0030] Relying on the peroxidase-like activity of hemoglobin in the intestine, which can catalyze the peroxide bond to become an electron acceptor and then produce an electrical signal change, guaiac is polymerized and embedded in the electrode 8, so that our shell material also has sensing properties.

[0031] The circuit board 6 is provided with a power supply unit 4, a single chip microcomputer 7 and a zigbee transmitting module 5. The power supply unit 4 is connected to the single chip microcomputer 7 and the zigbee transmitting module 5 to supply power to the single chip microcomputer 7 and the zigbee transmitting module 5, and the single chip microcomputer 7 is connected to the electrode 8 to obtain and record the change of the external electrical signal.

[0032] The single chip microcomputer 7 is connected to the zigbee sending module 5, and a host computer is arranged outside the human body. The host computer is connected to the zigbee sending module 5 by wireless communication. The single chip microcomputer 7 sends the collected data to the host computer software through the zigbee sending module 5, and the data is summarized and analyzed to achieve the purpose of judging whether there is occult blood.

[0033] In this embodiment, the model of the power supply unit 4 is B0505S-1WR1.

[0034] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0035] It should be understood that the above description is for illustration and not for limitation. Many embodiments and many applications beyond the examples provided will be apparent to those skilled in the art upon reading the above description. Therefore, the scope of the present teachings should not be determined with reference to the above description, but rather with reference to the foregoing claims and the full scope of equivalents to which such claims are entitled. For the purpose of comprehensiveness, all articles and references, including disclosures of patent applications and publications, are incorporated herein by reference. The omission of any aspect of the subject matter disclosed herein in the foregoing claims is not intended to be a waiver of such subject matter, nor should it be considered that the applicant has not considered such subject matter to be part of the disclosed inventive subject matter.

Claims

1. A human intestinal capsule for detecting occult blood, characterized in that: It comprises a housing and a circuit board (6) located inside the housing; The outer shell comprises an inner layer (3) and an outer layer (1), the material of the outer layer (1) is a double network hydrogel-guaiac complex, and an electrode (8) is arranged inside the outer layer (1); A power supply unit (4), a single-chip microcomputer (7) and a wireless transmission module are arranged on the circuit board (6); the power supply unit (4) is connected to the single-chip microcomputer (7) and the wireless transmission module; and the single-chip microcomputer (7) is connected to the electrode (8) and the wireless transmission module.

2. The human intestinal capsule for detecting occult blood according to claim 1, characterized in that: The material of the inner layer (3) is PET.

3. The human intestinal capsule for detecting occult blood according to claim 1, characterized in that: An intermediate layer (2) is arranged between the inner layer (3) and the outer layer (1).

4. The human intestinal capsule for detecting occult blood according to claim 3, characterized in that: The material of the middle layer (2) is GELMA.

5. The human intestinal capsule for detecting occult blood according to claim 1, characterized in that: A host computer is arranged outside the human body, and the host computer is connected with the wireless sending module by wireless communication.

6. The human intestinal capsule for detecting occult blood according to claim 1, characterized in that: The shell is a capsule-shaped structure.

7. The human intestinal capsule for detecting occult blood according to claim 1, characterized in that: The wireless sending module uses zigbee.

8. The human intestinal capsule for detecting occult blood according to claim 1, characterized in that: The power supply unit (4) model is B0505S-1WR1.

9. A method for detecting occult blood based on the human intestinal capsule for detecting occult blood according to any one of claims 1 to 8, characterized in that: The double network hydrogel in the outer layer (1) relies on the hemoglobin in the intestine to have an activity similar to that of peroxidase, catalyzing the peroxide bond to become an electron acceptor and thus generating an electrical signal change. The single chip microcomputer (7) records the electrical signal change outside the shell through the electrode (8), and transmits the collected data to the outside through the wireless transmission module, summarizes and analyzes the data, and determines whether there is occult blood.

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