Polypeptide dressing for skin repair

Abstract

The invention is suitable for the technical field of skin repair, and provides a polypeptide dressing for skin repair. The polypeptide dressing is prepared from the following components in percentage by weight: 0.6 to 0.8 percent of polypeptide composition, 0.1 to 0.2 percent of recombinant III type human collagen, 0.05 to 0.2 percent of silk fibroin, 0.1 to 0.3 percent of sodium hyaluronate, 0.2 to 0.4 percent of panthenol, 0.1 to 0.2 percent of bambusa veronii extract, 0.12 to 0.25 percent of allantoin, 4 to 5 percent of polyethylene glycol, 0.1 to 0.25 percent of carbomer homopolymer, 0.1 to 0.3 percent of triethanolamine, 0.15 to 0.2 percent of preservative, 25 to 30 percent of glycerol and 60 to 70 percent of water. Preferably, the polypeptide composition is prepared by compounding acetyl hexapeptide-8, acetyl dipeptide-1, carnosine and saccharomycetes polypeptide according to the mass ratio of 1: 1: 3: 5. The dressing prepared by the invention has multiple effects, the preparation method is simple, the required equipment is conventional, the production cost is low, and the produced polypeptide dressing is good in comfort and high in fitting degree with the face during use.

Description

Technical Field

[0001] The invention relates to the technical field of skin repair, in particular to a polypeptide dressing for skin repair. Background Art

[0002] In daily life, people are often exposed to multiple intrusions such as ultraviolet radiation, environmental pollution, and radiation from electronic products, which makes the skin dry and dehydrated, gradually loses its natural luster, and fine lines also quietly emerge, so some skin care products are often used. Peptide dressing is a skin care product containing peptide ingredients, which have good biological activity.

[0003] The main function of polypeptide dressings is to replenish water and promote skin repair. It can promote skin tissue regeneration and has a significant effect on repairing skin problems. The use of polypeptide dressings can quickly penetrate into the epidermis, quickly replenish the nutrients needed by the skin, directly activate and nourish skin cells, and thus enhance the elasticity of the skin. In addition, polypeptide dressings can also protect the skin, effectively promote skin metabolism, improve skin texture, and achieve the effect of repairing wrinkles and whitening. Therefore, polypeptide dressings are a good choice for skin care.

[0004] However, there is currently a lack of a polypeptide dressing that combines multiple hydrating, repairing, anti-inflammatory and antibacterial effects. Summary of the invention

[0005] The purpose of the present invention is to provide a polypeptide dressing for skin repair to solve the problems in the above-mentioned background technology.

[0006] To achieve the above object, the present invention provides the following technical solutions: In a first aspect, the present invention provides a polypeptide dressing for skin repair, wherein the components and contents of the polypeptide dressing are as follows, in terms of mass percentage:

[0007] 0.6-0.8% polypeptide composition, 0.1-0.2% recombinant human type III collagen, 0.05-0.2% silk fibroin, 0.1-0.3% sodium hyaluronate, 0.2-0.4% panthenol, 0.1-0.2% Weiss bamboo extract, 0.12-0.25% allantoin, 4-5% polyethylene glycol, 0.1-0.25% carbomer homopolymer, 0.1-0.3% triethanolamine, 0.15-0.2% preservative, 25-30% glycerin, and 60-70% water.

[0008] Preferably, the components and mass percentages of the polypeptide dressing are as follows:

[0009] 0.7% polypeptide composition, 0.2% recombinant human type III collagen, 0.15% silk fibroin, 0.2% sodium hyaluronate, 0.3% panthenol, 0.18% bear bamboo extract, 0.18% allantoin, 4.54% polyethylene glycol, 0.2% carbomer homopolymer, 0.16% triethanolamine, 0.19% preservative, 28% glycerin, and 65% water.

[0010] Preferably, the polypeptide composition is compounded by acetyl hexapeptide-8, acetyl dipeptide-1, carnosine and yeast polypeptides in a mass ratio of 1:1:3:5.

[0011] Preferably, the preservative is methylparaben.

[0012] The second aspect of the present invention provides a method for preparing the polypeptide dressing according to the first aspect of the present invention, comprising the following steps:

[0013] S1. Weigh the polypeptide composition, recombinant human collagen type III, silk fibroin, sodium hyaluronate, panthenol, bamboo extract, allantoin, polyethylene glycol, carbomer homopolymer, triethanolamine, preservative, glycerin, and water according to the proportion and set aside;

[0014] S2. Heat the panthenol, bamboo extract, allantoin, preservatives and water weighed in step S1 to 80° C., sprinkle sodium hyaluronate and carbomer homopolymer evenly on the liquid surface, heat for 30 min, stir for 10 min, and then homogenize and disperse for 5 to 10 min, cool to 40° C., add the polypeptide composition, recombinant type III human collagen, silk fibroin, polyethylene glycol, triethanolamine and glycerol weighed in step S1 in sequence, stir and react for 0.5 to 1 h, and cool to room temperature to obtain a dressing solution;

[0015] S3, filling the dressing liquid prepared in step S2 into an aluminum foil bag stacked with a dressing cloth for packaging, and packaging to obtain a polypeptide dressing for skin repair.

[0016] The present invention has at least the following beneficial effects:

[0017] The present invention provides a polypeptide dressing for skin repair. The prepared dressing has multiple functions, a simple preparation method, conventional equipment, and low production cost. In addition, the produced polypeptide dressing is comfortable to use and has a high degree of fit to the face. DETAILED DESCRIPTION

[0018] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0019] The present invention provides a polypeptide dressing for skin repair. The components and contents of the polypeptide dressing are as follows, in terms of mass percentage:

[0020] 0.6-0.8% polypeptide composition, 0.1-0.2% recombinant human type III collagen, 0.05-0.2% silk fibroin, 0.1-0.3% sodium hyaluronate, 0.2-0.4% panthenol, 0.1-0.2% Weiss bamboo extract, 0.12-0.25% allantoin, 4-5% polyethylene glycol, 0.1-0.25% carbomer homopolymer, 0.1-0.3% triethanolamine, 0.15-0.2% preservative, 25-30% glycerin, and 60-70% water.

[0021] Among them, the polypeptide composition is a compound of acetyl hexapeptide-8, acetyl dipeptide-1, carnosine and yeast polypeptides in a mass ratio of 1:1:3:5; the preservative is methylparaben.

[0022] The present invention also provides a method for preparing a polypeptide dressing for skin repair, comprising the following steps:

[0023] S1. Weigh the polypeptide composition, recombinant human collagen type III, silk fibroin, sodium hyaluronate, panthenol, bamboo extract, allantoin, polyethylene glycol, carbomer homopolymer, triethanolamine, preservative, glycerin, and water according to the proportion and set aside;

[0024] S2. Heat the panthenol, bamboo extract, allantoin, preservatives and water weighed in step S1 to 80° C., sprinkle sodium hyaluronate and carbomer homopolymer evenly on the liquid surface, heat for 30 min, stir for 10 min, and then homogenize and disperse for 5 to 10 min, cool to 40° C., add the polypeptide composition, recombinant type III human collagen, silk fibroin, polyethylene glycol, triethanolamine and glycerol weighed in step S1 in sequence, stir and react for 0.5 to 1 h, and cool to room temperature to obtain a dressing solution;

[0025] S3, filling the dressing liquid prepared in step S2 into an aluminum foil bag stacked with a dressing cloth for packaging, and packaging to obtain a polypeptide dressing for skin repair.

[0026] Based on the above technical solution, the present invention provides the following partial embodiments:

[0027] Example 1

[0028] A polypeptide dressing for skin repair comprises raw materials in the following proportions: 0.6% polypeptide composition, 0.1% recombinant type III human collagen, 0.05% silk fibroin, 0.1% sodium hyaluronate, 0.2% panthenol, 0.15% ursinica extract, 0.15% allantoin, 4.24% polyethylene glycol, 0.15% carbomer homopolymer, 0.11% triethanolamine, 0.15% preservative, 25% glycerol and 69% water.

[0029] The preparation method of the above polypeptide dressing comprises the following steps:

[0030] S1. Weigh the raw materials according to 0.6% of polypeptide composition, 0.1% of recombinant human type III collagen, 0.05% of silk fibroin, 0.1% of sodium hyaluronate, 0.2% of panthenol, 0.15% of bamboo extract, 0.15% of allantoin, 4.24% of polyethylene glycol, 0.15% of carbomer homopolymer, 0.11% of triethanolamine, 0.15% of preservative, 25% of glycerol and 69% of water, and set aside;

[0031] S2. Heat the panthenol, bamboo extract, allantoin, preservatives and water weighed in step S1 to 80° C., sprinkle sodium hyaluronate and carbomer homopolymer evenly on the liquid surface, heat for 30 min, stir for 10 min, and then homogenize and disperse for 5 min, cool to 40° C., add the polypeptide composition, recombinant type III human collagen, silk fibroin, polyethylene glycol, triethanolamine and glycerol weighed in step S1 in sequence, stir and react for 0.5 h, and cool to room temperature to obtain a dressing solution;

[0032] S3, filling the dressing liquid prepared in step S2 into an aluminum foil bag stacked with a dressing cloth for packaging, and packaging to obtain a polypeptide dressing for skin repair.

[0033] Example 2

[0034] A polypeptide dressing for skin repair comprises raw materials in the following proportions: 0.65% polypeptide composition, 0.2% recombinant type III human collagen, 0.1% silk fibroin, 0.15% sodium hyaluronate, 0.18% panthenol, 0.1% ursinica extract, 0.25% allantoin, 4.04% polyethylene glycol, 0.1% carbomer homopolymer, 0.06% triethanolamine, 0.17% preservative, 28% glycerol and 66% water.

[0035] The preparation method of the above polypeptide dressing comprises the following steps:

[0036] S1. Weigh the raw materials according to the following formula: 0.65% polypeptide composition, 0.2% recombinant human collagen type III, 0.1% silk fibroin, 0.15% sodium hyaluronate, 0.18% panthenol, 0.1% ursinus extract, 0.25% allantoin, 4.04% polyethylene glycol, 0.1% carbomer homopolymer, 0.06% triethanolamine, 0.17% preservative, 28% glycerol, 66% water, and set aside;

[0037] S2. Heat the panthenol, bamboo extract, allantoin, preservatives and water weighed in step S1 to 80° C., sprinkle sodium hyaluronate and carbomer homopolymer evenly on the liquid surface, heat for 30 min, stir for 10 min, and then homogenize and disperse for 6 min, cool to 40° C., add the polypeptide composition weighed in step S1, recombinant type III human collagen, silk fibroin, polyethylene glycol, triethanolamine and glycerol in sequence, stir and react for 0.6 h, and cool to room temperature to obtain a dressing solution;

[0038] S3, filling the dressing liquid prepared in step S2 into an aluminum foil bag stacked with a dressing cloth for packaging, and packaging to obtain a polypeptide dressing for skin repair.

[0039] Example 3

[0040] A polypeptide dressing for skin repair comprises raw materials in the following proportions: 0.7% polypeptide composition, 0.2% recombinant type III human collagen, 0.15% silk fibroin, 0.2% sodium hyaluronate, 0.3% panthenol, 0.18% ursinica extract, 0.18% allantoin, 4.54% polyethylene glycol, 0.2% carbomer homopolymer, 0.16% triethanolamine, 0.19% preservative, 28% glycerol and 65% water.

[0041] The preparation method of the above polypeptide dressing comprises the following steps:

[0042] S1. Weigh the raw materials according to the following formula: 0.7% polypeptide composition, 0.2% recombinant human collagen type III, 0.15% silk fibroin, 0.2% sodium hyaluronate, 0.3% panthenol, 0.18% ursinus extract, 0.18% allantoin, 4.54% polyethylene glycol, 0.2% carbomer homopolymer, 0.16% triethanolamine, 0.19% preservative, 28% glycerol, 65% water, and set aside.

[0043] S2. Heat the panthenol, bamboo extract, allantoin, preservatives and water weighed in step S1 to 80° C., sprinkle sodium hyaluronate and carbomer homopolymer evenly on the liquid surface, heat for 30 min, stir for 10 min, and then homogenize and disperse for 7 min, cool to 40° C., add the polypeptide composition weighed in step S1, recombinant type III human collagen, silk fibroin, polyethylene glycol, triethanolamine and glycerol in sequence, stir and react for 0.75 h, and cool to room temperature to obtain a dressing solution;

[0044] S3, filling the dressing liquid prepared in step S2 into an aluminum foil bag stacked with a dressing cloth for packaging, and packaging to obtain a polypeptide dressing for skin repair.

[0045] Example 4

[0046] A polypeptide dressing for skin repair comprises raw materials in the following proportions: 0.75% polypeptide composition, 0.1% recombinant type III human collagen, 0.05% silk fibroin, 0.1% sodium hyaluronate, 0.4% panthenol, 0.2% ursinica extract, 0.12% allantoin, 4.24% polyethylene glycol, 0.2% carbomer homopolymer, 0.16% triethanolamine, 0.18% preservative, 25.5% glycerol and 68% water.

[0047] The preparation method of the above polypeptide dressing comprises the following steps:

[0048] S1. Weigh the raw materials according to the following formula: 0.75% polypeptide composition, 0.1% recombinant human collagen type III, 0.05% silk fibroin, 0.1% sodium hyaluronate, 0.4% panthenol, 0.2% ursinus extract, 0.12% allantoin, 4.24% polyethylene glycol, 0.2% carbomer homopolymer, 0.16% triethanolamine, 0.18% preservative, 25.5% glycerol, 68% water, and set aside;

[0049] S2. Heat the panthenol, bamboo extract, allantoin, preservatives and water weighed in step S1 to 80° C., sprinkle sodium hyaluronate and carbomer homopolymer evenly on the liquid surface, heat for 30 min, stir for 10 min, and then homogenize and disperse for 8 min, cool to 40° C., add the polypeptide composition weighed in step S1, recombinant type III human collagen, silk fibroin, polyethylene glycol, triethanolamine and glycerol in sequence, stir and react for 0.8 h, and cool to room temperature to obtain a dressing solution;

[0050] S3, filling the dressing liquid prepared in step S2 into an aluminum foil bag stacked with a dressing cloth for packaging, and packaging to obtain a polypeptide dressing for skin repair.

[0051] Example 5

[0052] A polypeptide dressing for skin repair comprises raw materials in the following proportions: 0.8% polypeptide composition, 0.1% recombinant type III human collagen, 0.2% silk fibroin, 0.3% sodium hyaluronate, 0.2% panthenol, 0.1% ursinica extract, 0.2% allantoin, 4.94% polyethylene glycol, 0.25% carbomer homopolymer, 0.21% triethanolamine, 0.2% preservative, 26.5% glycerol and 66% water.

[0053] The preparation method of the above polypeptide dressing comprises the following steps:

[0054] S1. Weigh the raw materials according to the following formula: 0.7% polypeptide composition, 0.2% recombinant human collagen type III, 0.15% silk fibroin, 0.3% sodium hyaluronate, 0.3% panthenol, 0.18% ursinapicae extract, 0.18% allantoin, 4.94% polyethylene glycol, 0.25% carbomer homopolymer, 0.21% triethanolamine, 0.2% preservative, 26.5% glycerol, 66% water, and set aside;

[0055] S2. Heat the panthenol, bamboo extract, allantoin, preservatives and water weighed in step S1 to 80° C., sprinkle sodium hyaluronate and carbomer homopolymer evenly on the liquid surface, heat for 30 min, stir for 10 min, and then homogenize and disperse for 10 min, cool to 40° C., add the polypeptide composition, recombinant type III human collagen, silk fibroin, polyethylene glycol, triethanolamine and glycerol weighed in step S1 in sequence, stir for 1 h, and cool to room temperature to obtain a dressing solution;

[0056] S3, filling the dressing liquid prepared in step S2 into an aluminum foil bag stacked with a dressing cloth for packaging, and packaging to obtain a polypeptide dressing for skin repair.

[0057] Acetyl hexapeptide-8 in the present invention can slow down the force of muscle contraction, reduce the occurrence of dynamic lines and eliminate fine lines, effectively reorganize collagen elasticity, increase elastin activity, and smooth wrinkles. Acetyl dipeptide-1 has significant anti-inflammatory and soothing effects, can inhibit the release of inflammatory factors, stimulate the synthesis of collagen, and thus reduce skin inflammation and discomfort. Carnosine has high activity and small molecules, and has the effects of anti-aging, anti-oxidation, anti-glycation, whitening and brightening skin color. Yeast polypeptides can promote the metabolism of skin cells, stimulate cell regeneration and proliferation, help repair the skin barrier, and enhance the elasticity and luster of the skin. The combined use of the above polypeptides can play multiple functions, which is conducive to repairing the skin and maintaining a healthy state.

[0058] The dressing prepared by the present invention has multiple functions. It uses water and glycerin as the medium, and can achieve the effects of anti-wrinkle repair, anti-allergic soothing, and whitening and lightening spots by adding different types of polypeptides. Recombinant type III human collagen and silk fibroin improve inflammatory damage, promote skin repair, and effectively delay aging. The combination of sodium hyaluronate, panthenol, Weiss bamboo extract, allantoin, and polyethylene glycol can promote the stratum corneum to absorb water, increase hydration, and provide the skin with a moist and translucent effect. At the same time, it regulates the skin, moisturizes and resists bacteria, making it smoother, and relieves dryness and roughness caused by sun exposure. Long-term use can improve skin problems. Finally, the polypeptide dressing was successfully prepared by carbomer homopolymer, triethanolamine, and preservatives.

[0059] In the production process of the present invention, the high temperature resistant material is first stirred and homogenized at 80°C to form a uniform liquid, and then the polypeptide composition, recombinant type III human collagen and other materials are added in sequence after cooling, so as to give full play to the effects of different materials. The production method proposed by the present invention is simple, requires conventional equipment, has low production cost, and the produced polypeptide dressing has good comfort when used and has a high degree of fit to the face.

[0060] The components of the above embodiments 1-5 are shown in Table 1 below:

[0061] Table 1

[0062] name Example 1 Example 2 Example 3 Example 4 Example 5 Peptide composition 0.6％ 0.65％ 0.7％ 0.75％ 0.8％ Recombinant human collagen type Ⅲ 0.1％ 0.2％ 0.2％ 0.1％ 0.1％ Silk Fibroin 0.05％ 0.1％ 0.15％ 0.05％ 0.2％ Sodium Hyaluronate 0.1％ 0.15％ 0.2％ 0.1％ 0.3％ Panthenol 0.2％ 0.18％ 0.3％ 0.4％ 0.2％ Weiss Bamboo Extract 0.15％ 0.1％ 0.18％ 0.2％ 0.1％ Allantoin 0.15％ 0.25％ 0.18％ 0.12％ 0.2％ Polyethylene glycol 4.24％ 4.04％ 4.54％ 4.24％ 4.94％ Carbomer Homopolymer 0.15％ 0.1％ 0.2％ 0.2％ 0.25％ Triethanolamine 0.11％ 0.06％ 0.16％ 0.16％ 0.21％ preservative 0.15％ 0.17％ 0.19％ 0.18％ 0.2％ glycerin 25％ 28％ 28％ 25.5％ 26.5％ Purified water 69％ 66％ 65％ 68％ 66％

[0063] A series of relevant performance tests were conducted on the polypeptide dressings prepared in Examples 1-5 above, and the results are as follows:

[0064] Effect test:

[0065] 140 volunteers were selected, and all of them had different skin problems, such as acne, acne, large oil production, large pores, acne, spots, dry and peeling skin, wrinkles, etc. The 140 volunteers were divided into seven groups, and the subjects in each group were aged 30-50 years old, with 20 people, similar skin problems, half male and half female, and dispersed age. The polypeptide dressings for skin repair obtained in Examples 1-5 were tested for use effects, and two groups of control experiments were added, wherein control group 1 was a commercially available dressing; the formula of control group 2 was different from the polypeptide dressing of Example 3 in that no polypeptide composition was added, a total of seven groups of experiments, Examples 1-5 corresponded to experimental groups 1-5, control group 1 was experimental group 6, and control group 2 was experimental group 7. The experimental duration was 2 months, and the dressing was used every 2 days, and each time it was used for 15-20 minutes. After 2 months of use, the volunteers gave feedback on their own skin conditions, with a total score of 100 points, and were evaluated from 5 aspects, respectively. The evaluation criteria are shown in Table 2, and the scoring results are shown in Table 3.

[0066] Table 2

[0067]

[0068] Table 3

[0069]

[0070]

[0071] The experimental results show that the polypeptide dressings prepared in Examples 1 to 5 of the present invention can effectively improve skin problems and are more popular with volunteers than those in Control Groups 1 and 2. They can repair damaged skin barriers, enhance skin resistance, and reduce damage to the skin caused by external stimuli.

[0072] The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. It is obvious to those skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims are included in the present invention.

[0073] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A polypeptide dressing for skin repair, characterized in that: In terms of mass percentage, the components and contents of the polypeptide dressing are as follows: 0.6-0.8% polypeptide composition, 0.1-0.2% recombinant human type III collagen, 0.05-0.2% silk fibroin, 0.1-0.3% sodium hyaluronate, 0.2-0.4% panthenol, 0.1-0.2% Weiss bamboo extract, 0.12-0.25% allantoin, 4-5% polyethylene glycol, 0.1-0.25% carbomer homopolymer, 0.1-0.3% triethanolamine, 0.15-0.2% preservative, 25-30% glycerin, and 60-70% water.

2. The polypeptide dressing for skin repair according to claim 1, characterized in that: The components and mass percentages of the polypeptide dressing are as follows: 0.7% polypeptide composition, 0.2% recombinant human type III collagen, 0.15% silk fibroin, 0.2% sodium hyaluronate, 0.3% panthenol, 0.18% bear bamboo extract, 0.18% allantoin, 4.54% polyethylene glycol, 0.2% carbomer homopolymer, 0.16% triethanolamine, 0.19% preservative, 28% glycerin, and 65% water.

3. A polypeptide dressing for skin repair according to claim 1, characterized in that: The polypeptide composition is prepared by compounding acetyl hexapeptide-8, acetyl dipeptide-1, carnosine and yeast polypeptides in a mass ratio of 1:1:3:

5.

4. The polypeptide dressing for skin repair according to claim 1, characterized in that: The preservative is methylparaben.

5. The method for preparing the polypeptide dressing according to any one of claims 1 to 4, characterized in that: The following steps are involved: S1. Weigh the polypeptide composition, recombinant human collagen type III, silk fibroin, sodium hyaluronate, panthenol, bamboo extract, allantoin, polyethylene glycol, carbomer homopolymer, triethanolamine, preservative, glycerin, and water according to the proportion and set aside; S2. Heat the panthenol, bamboo extract, allantoin, preservatives and water weighed in step S1 to 80° C., sprinkle sodium hyaluronate and carbomer homopolymer evenly on the liquid surface, heat for 30 min, stir for 10 min, and then homogenize and disperse for 5 to 10 min, cool to 40° C., add the polypeptide composition, recombinant type III human collagen, silk fibroin, polyethylene glycol, triethanolamine and glycerol weighed in step S1 in sequence, stir and react for 0.5 to 1 h, and cool to room temperature to obtain a dressing solution; S3, filling the dressing liquid prepared in step S2 into an aluminum foil bag stacked with a dressing cloth for packaging, and packaging to obtain a polypeptide dressing for skin repair.

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