Traditional Chinese medicine composition for promoting blood circulation, removing blood stasis, eliminating symptoms and removing stasis as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention provides a traditional Chinese medicine composition for promoting blood circulation, removing blood stasis, eliminating symptoms and removing stasis as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition provided by the invention is prepared from the following raw materials: turtle shell, radix salviae miltiorrhizae, radix paeoniae rubra, peach kernel, leech, oldenlandia diffusa, rhizoma sparganii, curcuma zedoary, herba lycopi, radix achyranthis bidentatae, cinnamon, leonurus, liquorice, cudrania cochinchinensis, loofah sponge, spina gleditsiae and thunberg fritillary bulb. The traditional Chinese medicine composition achieves the purpose of discharging tissues or promoting tissue absorption by activating blood circulation, removing blood stasis, eliminating symptoms and removing stasis, can well protect the intima and regenerate the damaged intima, and has remarkable curative effects on placenta implantation, incomplete abortion, scar pregnancy, repair of endometrium or treatment of intrauterine adhesion. Clinical observation shows that patients with placenta implantation or incomplete abortion are pregnant again within a short time after being treated by using the traditional Chinese medicine composition, and a good pregnancy outcome is obtained.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for promoting blood circulation, removing blood stasis, relieving symptoms and dispersing nodules, and a preparation method and application thereof. Background Art

[0002] Placenta accreta refers to the penetration of placental villi into part of the uterine wall muscle layer, which occurs in early pregnancy. Placenta accreta is one of the serious obstetric complications, which can lead to massive hemorrhage, shock, uterine perforation, secondary infection, and even death in the parturient. Multiple births, artificial abortion, induced labor, cesarean section, puerperal infection, history of hysterotomy, history of pelvic radiotherapy, placenta previa, and advanced age are considered to be high-risk factors for placenta accreta. Incomplete abortion usually refers to incomplete abortion, which means that the gestational sac is not completely discharged from the uterine cavity after abortion, or there are residual substances in the uterine cavity that are not completely discharged. At present, the treatment methods for refractory incomplete abortion and placenta accreta are relatively limited, and generally hysteroscopic diagnosis and treatment are the main method. However, clinically, for residues in special parts such as pregnancy in the uterine angles on both sides, malformed uterus, scars, scar diverticula, or placenta accreta, hysteroscopic electroresection alone cannot effectively and completely remove the lesions, because electroresection in special parts is difficult to accurately remove even under hysteroscopy, at the cost of damage to the endometrium and myometrium, and even uterine rupture. Moreover, the area and depth of damage caused by large residues are also larger, and the degree of damage will be more severe, greatly increasing the risk of uterine cavity adhesions, reduced menstrual volume, and infertility in the future. It is even more fatal to patients who have not given birth. HIFU is also a new treatment method for scar pregnancy in recent years. It is effective for some scar pregnancy and incomplete abortion, but lesions on the posterior wall and accidental injury to the endometrium are also the shortcomings of this treatment. In addition, the high cost makes it impossible to popularize it at present. Summary of the invention

[0003] In view of this, the present invention provides a Chinese medicine composition for promoting blood circulation, removing blood stasis, eliminating symptoms and dispersing nodules based on the limitations of the current diagnosis and treatment methods for placenta accreta or incomplete abortion. The Chinese medicine composition provided by the present invention achieves the purpose of expelling tissue or promoting tissue absorption by promoting blood circulation, removing blood stasis, eliminating symptoms and dispersing nodules, and can well protect the endometrium and regenerate the damaged endometrium. It has significant therapeutic effects on the repair of endometrium, the treatment of placenta accreta or incomplete abortion and intrauterine adhesions.

[0004] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0005] The invention provides a traditional Chinese medicine composition for promoting blood circulation, removing blood stasis, eliminating symptoms and dispersing nodules. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-30 parts of turtle shell, 10-60 parts of salvia miltiorrhiza, 10-60 parts of red peony root, 10-30 parts of peach kernel, 3-15 parts of leech, 10-30 parts of oldenlandia diffusa, 10-30 parts of trigonosciadium japonicum, 10-30 parts of zedoaria, 10-30 parts of zedoaria, 10-30 parts of achyranthes bidentata, 5-15 parts of cinnamon bark, 10-60 parts of motherwort, 5-20 parts of liquorice, 10-30 parts of scutellaria baicalensis, 10-60 parts of luffa, 5-20 parts of thorny gleditsia and 10-30 parts of fritillaria thunbergii.

[0006] Preferably, the Chinese medicine composition comprises the following raw materials in parts by weight: 15-20 parts of turtle shell, 15-30 parts of salvia miltiorrhiza, 15-20 parts of red peony root, 15-20 parts of peach kernel, 5-10 parts of leech, 15-30 parts of oldenlandia diffusa, 15-20 parts of trillium, 15-20 parts of zedoaria, 10-15 parts of zedoaria, 10-15 parts of achyranthes bidentata, 5-10 parts of cinnamon bark, 15-30 parts of motherwort, 10-15 parts of liquorice, 15-20 parts of scutellaria baicalensis, 15-30 parts of luffa, 10-15 parts of gleditsia thorns, and 15-30 parts of thunbergia thunbergii.

[0007] Preferably, the traditional Chinese medicine composition further comprises the following raw materials in parts by weight: 5-30 parts of angelica and 10-60 parts of astragalus.

[0008] Preferably, the traditional Chinese medicine composition further comprises the following raw materials in parts by weight: 15-30 parts of Scrophularia ningpoensis or 15-30 parts of Radix Trichosanthis.

[0009] Preferably, the traditional Chinese medicine composition further comprises the following raw materials in parts by weight: 10-15 parts of cassia twig.

[0010] Preferably, the traditional Chinese medicine composition further comprises the following raw materials in parts by weight: 15-30 parts of Radix Trichosanthis and 15-30 parts of Artemisia Capillaris.

[0011] The present invention also provides a method for preparing the above-mentioned traditional Chinese medicine composition, comprising the following steps: mixing water and turtle shell, boiling over high heat and then simmering over low heat for 20-30 minutes, adding the remaining raw materials, boiling and then decocting over low heat for 20-30 minutes.

[0012] Preferably, the amount of water added is such that the water surface covers all the raw material mixture by 2cm-5cm.

[0013] The present invention also provides a traditional Chinese medicine preparation for repairing endometrium, treating placenta implantation or treating incomplete abortion, which is prepared from the above-mentioned traditional Chinese medicine composition and auxiliary materials.

[0014] The present invention also provides an application of the traditional Chinese medicine composition in preparing a medicine for repairing endometrium, treating placenta implantation or treating incomplete abortion.

[0015] Beneficial effects of the present invention:

[0016] The Chinese medicine composition provided by the present invention achieves the purpose of discharging tissue or promoting tissue absorption by promoting blood circulation, removing blood stasis, eliminating symptoms and dispersing knots, and can well protect the endometrium and regenerate the damaged endometrium, and has significant therapeutic effects on the repair of endometrium, the treatment of placenta implantation or incomplete abortion, and intrauterine adhesion. Clinical observation shows that patients with placenta implantation or incomplete abortion become pregnant again in a relatively short period of time after being treated with the Chinese medicine composition of the present invention, and obtain good pregnancy outcomes.

[0017] The Chinese medicine composition provided by the present invention has a cure rate of more than 97% for patients with placenta accreta, incomplete abortion, and scar pregnancy, and the cure rate is very high. It also has a good protective effect on the endometrium. After the patients with placenta accreta or incomplete abortion treated with the Chinese medicine composition provided by the present invention, B-ultrasound or hysteroscopy examinations are repeated, and the endometrium is significantly improved, the pregnancy rate is greatly improved, and the intrauterine adhesion is significantly improved or even completely recovered. DETAILED DESCRIPTION

[0018] The invention provides a traditional Chinese medicine composition for promoting blood circulation, removing blood stasis, eliminating symptoms and dispersing nodules. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-30 parts of turtle shell, 10-60 parts of salvia miltiorrhiza, 10-60 parts of red peony root, 10-30 parts of peach kernel, 3-15 parts of leech, 10-30 parts of oldenlandia diffusa, 10-30 parts of trigonosciadium japonicum, 10-30 parts of zedoaria, 10-30 parts of zedoaria, 10-30 parts of achyranthes bidentata, 5-15 parts of cinnamon bark, 10-60 parts of motherwort, 5-20 parts of liquorice, 10-30 parts of scutellaria baicalensis, 10-0 parts of luffa, 5-20 parts of thorny gleditsia and 10-30 parts of fritillaria thunbergii. The Chinese medicine composition preferably includes the following raw materials in parts by weight: 14-16 parts of turtle shell, 29-31 parts of salvia miltiorrhiza, 14-16 parts of red peony root, 14-16 parts of peach kernel, 4-5 parts of leech, 14-16 parts of oldenlandia diffusa, 14-16 parts of trillium, 14-16 parts of curcuma, 14-16 parts of zedoaria, 14-16 parts of cyperus, 14-16 parts of achyranthes bidentata, 9-11 parts of cinnamon bark, 29-31 parts of motherwort, 9-11 parts of liquorice, 14-16 parts of scutellaria baicalensis, 29-31 parts of luffa, 14-16 parts of gleditsia thorn, and 19-21 parts of thunbergia thunbergii.

[0019] There is no special record of "placenta accreta" in ancient books. Ancient doctors classified it into the categories of "retained placenta" and "postpartum lochia" according to its symptom manifestations. Some people also classified placenta accreta and intrauterine residue as "blood accumulation" and "lumps", and incomplete abortion belongs to the category of "abortion" and "miscarriage". There is no unified pathogenesis, but it can be attributed to the damage of Chong and Ren meridians, the poor circulation of Qi and blood, the retention of blood away from the meridians, the stasis of Chong and Ren meridians and the formation of masses, the internal obstruction of blood stasis, and the difficulty of new blood to settle. In the Chinese medicine composition of the present invention, Danshen has the same function as the four ingredients, is bitter and slightly pungent, and can promote blood circulation and remove blood stasis, cool blood and eliminate carbuncle. This prescription reuses Danshen because Danshen is a warm medicine, which can effectively dilate the coronary artery and the surrounding blood vessels, improve blood circulation in the body, and shorten the hemoglobin and red blood cell Recovery time, effectively promote tissue repair, stasis, stagnation and obstruction are the root causes of this disease, Danshen is used heavily, dilates blood vessels, improves microcirculation, improves stasis and obstruction, and promotes the self-disintegration of lesion cells; Red Peony Root enters the Liver Channel, clears away heat and cools blood, disperses stasis and relieves pain; Peach Kernel enters the blood, breaks blood and removes blood stasis; Trigonosciadium and Curcuma Atractylodes belong to the Liver and Spleen Channels, break blood, promote qi and eliminate accumulation, break stasis and disperse nodules, accelerate the apoptosis of trophoblastic cell disintegration, and promote the necrosis and shedding of lesions; Danshen, Red Peony Root, Peach Kernel, Trigonosciadium and Curcuma Atractylodes together have the effects of promoting blood circulation and removing stasis, breaking blood circulation and eliminating symptoms; Turtle Shell nourishes the kidney and suppresses yang, softens and disperses nodules, softens lesions and facilitates the absorption of lesion necrosis; Leech breaks blood, removes stasis, unblocks the meridians and disperses nodules. Leech has a strong power to break stasis, and with peach kernel that enters the blood, its medicinal effect can reach the diseased area directly, so that stasis can be removed and new blood can be generated, and the placenta can be discharged when blood flows back to the meridians. The above seven herbs (turtle shell, salvia miltiorrhiza, red peony root, peach kernel, leech, three-edged sword and curcuma) are all monarch drugs, which have the effects of softening and dispersing nodules, clearing away heat and discharging pus, breaking blood and eliminating symptoms. In the prescription, Gleditsia sinensis extracts toxins, reduces swelling and discharges pus; Fritillaria thunbergii clears heat and resolves phlegm, relieves depression and disperses nodules; Leonurus japonicus promotes blood circulation and regulates menstruation, removes blood stasis and promotes new blood; Hedyotis diffusa clears heat and detoxifies, eliminates carbuncle and disperses nodules; blood stasis and heat are intertwined, which is the source of long-term illness. Both herbs (Hedyotis diffusa and Leonurus japonicus) have the effects of clearing heat and regulating blood, removing dampness and discharging toxins, and promoting the disappearance of lesions. In addition, there are more herbs for promoting blood circulation and dispersing blood stasis in the Chinese medicine composition of the present invention, which is easy to warm and dry. The two herbs (Hedyotis diffusa and Leonurus japonicus) can prevent its dry and hot nature. , without hurting the effect of promoting blood circulation, and the ministerial medicines of Gleditsia sinensis warming and Houttuynia cordata cooling blood, one warm and one cool, play the role of detoxification and pain relief; Ze Lan belongs to the liver and spleen meridians, can break blood, and clear long-term accumulation; Achyranthes bidentata nourishes the liver and kidneys, strengthens the tendons and bones, removes blood stasis and dredges the meridians, and leads the septic blood downward. These six medicines (Gleditsia sinensis, Fritillaria thunbergii, Leonurus japonicus, Houttuynia cordata, Ze Lan and Achyranthes bidentata) take advantage of the momentum of promoting blood circulation, removing blood stasis and eliminating symptoms of the monarch medicine, further destroy the lesion tissue, lead the evil out to achieve the effect of clearing the lesion, and are all ministerial medicines. Luffa cools blood and oozes blood, promotes blood circulation and dredges the meridians, so that the products of removing blood stasis are reused without hurting the body; Chuanpo Stone dispels wind and dredges the meridians, clears heat and removes dampness, detoxifies and reduces swelling; Cinnamon bark replenishes fire and helps yang, warms the meridians and dredges, and can be used together with Achyranthes bidentata to warm and lead downward, and lead blood to the fetus. Luffa, Chuanpo Stone and Cinnamon bark are all adjuvants. Licorice harmonizes all medicines and protects the spleen and stomach.

[0020] There is no record of placenta accreta in traditional medicine, and it is mostly based on the classification of retained placenta. The main pathogenesis of placenta accreta is stasis, obstruction, and stagnation, and blood stasis runs through the whole process of the disease, but different stages of the disease and different basic constitutions of patients may cause concurrent symptoms such as qi deficiency, blood deficiency, and yin deficiency. If the patient has fatigue, shortness of breath, worsening with movement, less energy and lazy speech, pale or stagnant complexion, pale tongue, deep and thin pulse, etc., qi and blood deficiency is considered. If the patient has qi and blood deficiency, angelica and astragalus need to be added to the Chinese medicine composition of the present invention, and the weight of the angelica is preferably 5-30 parts, more preferably 5-15 parts, and the weight of the astragalus is preferably 10-60 parts, more preferably 20-40 parts. If the patient has dry mouth, yellow urine, constipation, red tongue with thin fur, and thin pulse, it is considered that the patient has yin deficiency and blood stasis, and it is necessary to add Scrophularia or Radix Trichosanthis to the Chinese medicine composition of the present invention, and the weight portion of Scrophularia is preferably 15-30 parts, and the weight portion of Radix Trichosanthis is preferably 15-30 parts. Long-term illness causes poor blood circulation, blood stasis in the meridians, or the patient has a cold constitution, but the patient is afraid of cold and has cold limbs, and the sublingual meridians are tortuous, then it is necessary to add cinnamon twigs to the Chinese medicine composition of the present invention, and the weight portion of cinnamon twigs is preferably 10-15 parts.

[0021] In the present invention, if the human chorionic gonadotropin (HCG) of patients with placenta implantation or incomplete abortion is lower than 300mIU / ml, the Chinese medicine composition provided by the present invention is used alone for treatment, but if the β subunit of human chorionic gonadotropin (β-HCG) is above 300mIU / ml, it is recommended to take the Chinese medicine composition of the present invention and mifepristone at the same time, and the dosage of the mifepristone is preferably 50mg, once a day. When β-HCG is above 300mIU / ml, it is preferred to add Radix Trichosanthis and Artemisia Capillaris to the Chinese medicine composition of the present invention, and the dosage of Radix Trichosanthis is preferably 15-30 parts, and the dosage of Artemisia Capillaris is preferably 15-30 parts.

[0022] The present invention also provides a method for preparing the above-mentioned Chinese medicine composition, comprising the following steps: mixing water and turtle shell, boiling over high heat and then simmering over low heat for 20-30 minutes, adding the remaining medicines, boiling and then decocting over low heat for 20-30 minutes.

[0023] In the preparation method of the present invention, the amount of water added is preferably such that the water surface covers all the drug mixture by 2cm-5cm, and more preferably the water surface covers the mixture by 3cm-4cm. In the present invention, after mixing water with turtle shell, it is preferably soaked first and then boiled over high heat. The soaking time is preferably 30min-40min, and more preferably 35min. In the preparation method of the present invention, after the decoction is completed, the liquid is collected to obtain the first decoction liquid, and preferably a second soaking and decoction is required, specifically: the drug residue is mixed with water and soaked for 30min-40min, then boiled, and then decocted on low heat for 20-30min, and the second decoction liquid is collected. The first decoction liquid and the second decoction liquid are mixed to obtain the Chinese medicine composition. The method of taking the Chinese medicine composition of the present invention is: after mixing the first decoction liquid and the second decoction liquid, they are evenly divided into two portions, and taken once in the morning and evening. In the present invention, the dosage relationship between the drug residue and water is: the water surface covers the drug residue by 1cm-3cm. The present invention has no special limitation on high heat and low heat, and the high heat and low heat in the conventional sense in the art can be used.

[0024] The present invention also provides a traditional Chinese medicine preparation for repairing endometrium, treating placenta implantation or treating incomplete abortion, which is prepared from the above-mentioned traditional Chinese medicine composition and auxiliary materials.

[0025] In the present invention, the dosage form of the Chinese medicine preparation preferably includes decoction, capsule, tablet, granule or pill. The present invention has no special limitation on the specific types of auxiliary materials.

[0026] The present invention also provides an application of the traditional Chinese medicine composition in preparing a medicine for repairing endometrium, treating placenta implantation or treating incomplete abortion.

[0027] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0028] In the following embodiments, unless otherwise specified, all of them are conventional methods.

[0029] Unless otherwise specified, the materials and reagents used in the following examples can be obtained from commercial sources.

[0030] Example 1

[0031] A traditional Chinese medicine composition for the treatment of patients with placenta accreta, which can invigorate blood circulation, dispel blood stasis, and eliminate symptoms and resolve nodules. The traditional Chinese medicine composition is prepared from the following raw materials by weight: 15g of turtle shell, 30g of salvia miltiorrhiza, 15g of red peony root, 15g of peach kernel, 5g of leech, 15g of oldenlandia diffusa, 15g of trifoliate lanceolate, 15g of zedoaria, 15g of zedoaria, 15g of achyranthes bidentata, 5g of cinnamon bark, 15g of motherwort, 10g of liquorice, 15g of scutellaria baicalensis, 15g of luffa, 10g of thorny gleditsia, and 15g of fritillaria thunbergii.

[0032] The preparation method comprises the following steps:

[0033] Mix water (the amount of water added is such that the water surface covers all the raw material mixture by 3 cm) with turtle shell, soak for 30 minutes, then boil over high heat, and then simmer over low heat for 30 minutes, then add other raw materials, boil over low heat for 30 minutes, collect the liquid to obtain the first decoction liquid; mix the drug residue with water (the amount of water added is such that the water surface covers the drug residue by 2 cm), soak for 30 minutes, then boil, and then simmer over low heat for 30 minutes, collect the liquid to obtain the second decoction liquid. Mix the first decoction liquid and the second decoction liquid to obtain the Chinese medicine composition.

[0034] Example 2

[0035] A traditional Chinese medicine composition for promoting blood circulation, removing blood stasis, eliminating symptoms and dispersing nodules, which is suitable for treating patients with placenta accreta. The traditional Chinese medicine composition is prepared from the following raw materials by weight: 20g of turtle shell, 30g of salvia miltiorrhiza, 20g of red peony root, 15g of peach kernel, 10g of leech, 30g of oldenlandia diffusa, 30g of trigonosciadium japonicum, 30g of curcuma, 20g of zedoaria, 15g of achyranthes bidentata, 10g of cinnamon bark, 30g of motherwort, 15g of liquorice, 20g of scutellaria baicalensis, 30g of luffa, 20g of thorny gleditsia, and 20g of fritillaria thunbergii.

[0036] The preparation method comprises the following steps:

[0037] Mix water (the amount of water added is such that the water surface covers all the raw material mixture by 4 cm) with turtle shell, soak for 40 minutes, then boil over high heat, and then simmer over low heat for 20 minutes, then add other raw materials, boil over low heat for 20 minutes, collect the liquid to obtain the first decoction liquid; mix the drug residue with water (the amount of water added is such that the water surface covers the drug residue by 1 cm), soak for 40 minutes, then boil, and then simmer over low heat for 20 minutes, collect the liquid to obtain the second decoction liquid. Mix the first decoction liquid and the second decoction liquid to obtain the Chinese medicine composition.

[0038] Example 3

[0039] A Chinese medicine composition for promoting blood circulation, removing blood stasis, and dispersing symptoms and stagnation, which is suitable for treating patients with placenta accreta with a β-HCG level of more than 300mIU / ml, is prepared from the following raw materials by weight: 15g of turtle shell, 30g of salvia miltiorrhiza, 15g of red peony root, 15g of peach kernel, 10g of leech, 30g of oldenlandia diffusa, 15g of trillium, 15g of zedoaria, 15g of zedoaria, 15g of achyranthes bidentata, 5g of cinnamon bark, 30g of motherwort, 15g of liquorice, 15g of scutellaria baicalensis, 30g of luffa, 10g of thorny gleditsia, 15g of fritillaria thunbergii, 30g of root of trichosanthes, and 30g of capillaris.

[0040] The preparation method is the same as that of Example 1.

[0041] Example 4

[0042] A Chinese medicine composition for promoting blood circulation, removing blood stasis, eliminating symptoms and dispersing nodules, which is suitable for treating patients with placenta accreta caused by qi and blood deficiency. The Chinese medicine composition is prepared from the following raw materials by weight: 15g of turtle shell, 30g of salvia miltiorrhiza, 15g of red peony root, 15g of peach kernel, 5g of leech, 15g of oldenlandia diffusa, 15g of trigonosciadium japonicum, 15g of curcuma, 15g of zedoaria, 15g of achyranthes bidentata, 5g of cinnamon bark, 15g of motherwort, 10g of liquorice, 15g of scutellaria baicalensis, 15g of luffa, 10g of thorny gleditsia, 15g of fritillaria thunbergii, 30g of astragalus, and 10g of angelica sinensis.

[0043] The preparation method is the same as that of Example 1.

[0044] Example 5

[0045] A Chinese medicine composition for promoting blood circulation, removing blood stasis, and eliminating symptoms and dispersing nodules suitable for treating patients with yin deficiency, blood stasis, and placenta accreta. The Chinese medicine composition is prepared from the following raw materials by weight: 15g of turtle shell, 30g of salvia miltiorrhiza, 15g of red peony root, 15g of peach kernel, 5g of leech, 15g of oldenlandia diffusa, 15g of trigonosciadium japonicum, 15g of curcuma, 15g of zedoaria, 15g of achyranthes bidentata, 5g of cinnamon bark, 15g of motherwort, 10g of liquorice, 15g of scutellaria baicalensis, 15g of luffa, 10g of thorny gleditsia, 15g of fritillaria thunbergii, and 20g of scrophularia ningpoensis.

[0046] The preparation method is the same as that of Example 1.

[0047] Example 6

[0048] A Chinese medicine composition for promoting blood circulation, removing blood stasis, eliminating symptoms and dispersing nodules, which is suitable for treating patients with placenta accreta caused by both qi and yin injury (qi and blood deficiency and yin deficiency and blood stasis). The Chinese medicine composition is prepared from the following raw materials by weight: 15g of turtle shell, 30g of salvia miltiorrhiza, 15g of red peony root, 15g of peach kernel, 5g of leech, 15g of oldenlandia diffusa, 15g of trigonosciadium japonicum, 15g of curcuma, 15g of zedoaria, 15g of achyranthes bidentata, 5g of cinnamon bark, 15g of motherwort, 10g of liquorice, 15g of scutellaria baicalensis, 15g of luffa, 10g of thorny gleditsia, 15g of fritillaria thunbergii, 10g of astragalus, 6g of angelica sinensis and 30g of scrophularia ningpoensis.

[0049] The preparation method is the same as Example 1.

[0050] Example 7

[0051] A Chinese medicine composition for promoting blood circulation, removing blood stasis, eliminating symptoms and dispersing nodules, which is suitable for treating patients with long-term illness of poor blood circulation, meridian stasis and placenta implantation. The Chinese medicine composition is prepared from the following raw materials by weight: 15g of turtle shell, 30g of salvia miltiorrhiza, 15g of red peony root, 15g of peach kernel, 5g of leech, 15g of oldenlandia diffusa, 15g of trigonosciadium japonicum, 15g of curcuma, 15g of zedoaria, 15g of achyranthes bidentata, 5g of cinnamon bark, 15g of motherwort, 10g of liquorice, 15g of scutellaria baicalensis, 15g of luffa, 10g of thorny gleditsia, 15g of fritillaria thunbergii and 10g of cassia twig.

[0052] The preparation method is the same as Example 1.

[0053] Example 8

[0054] A Chinese medicine composition for promoting blood circulation, removing blood stasis, and eliminating symptoms and stagnation, which is suitable for treating patients with qi and blood deficiency, chills, cold limbs, tortuous sublingual meridians and placenta accreta. The Chinese medicine composition is prepared from the following raw materials by weight: 15g of turtle shell, 30g of salvia miltiorrhiza, 15g of red peony root, 15g of peach kernel, 10g of leech, 15g of oldenlandia diffusa, 15g of trigonosciadium japonicum, 15g of curcuma, 15g of zedoaria, 15g of achyranthes bidentata, 5g of cinnamon bark, 15g of motherwort, 10g of liquorice, 15g of scutellaria baicalensis, 30g of luffa, 15g of thorny gleditsia, 20g of fritillaria thunbergii, 10g of cassia twig, 30g of astragalus, and 10g of angelica sinensis.

[0055] The preparation method is the same as Example 1.

[0056] Example 9

[0057] A Chinese medicine composition for promoting blood circulation, removing blood stasis, eliminating symptoms and dispersing nodules, which is suitable for treating patients with large-area or even entire placenta implantation that cannot be delivered after childbirth. The Chinese medicine composition is prepared from the following raw materials by weight: 30g of turtle shell, 60g of salvia miltiorrhiza, 20g of red peony root, 30g of peach kernel, 10g of leech, 15g of oldenlandia diffusa, 20g of trigonosciadium japonicum, 20g of curcuma, 15g of zedoaria, 15g of achyranthes bidentata, 10g of cinnamon bark, 30g of motherwort, 20g of liquorice, 15g of radix scutellariae, 30g of luffa, 15g of thorny gleditsiae, 30g of fritillaria thunbergii, 10g of cassia twig, 60g of astragalus, and 15g of angelica sinensis.

[0058] Example 10

[0059] (1) Case inclusion criteria:

[0060] ① Aged between 25 and 45 years old, meeting the diagnostic criteria of Western medicine and the criteria of traditional Chinese medicine;

[0061] ② Those whose B-ultrasound after delivery or abortion indicates residual or placenta implantation in the uterine cavity or scar pregnancy;

[0062] ③ Those with stable vital signs and no hemorrhagic shock;

[0063] ④No heavy vaginal bleeding;

[0064] ⑤ Those with normal body temperature, no odor in lochia, and no obvious signs of uterine infection.

[0065] The data were collected from cases of placenta accreta, incomplete abortion, and scar pregnancy treated in our hospital from January 2018 to June 2024.

[0066] (2) Treatment options

[0067] Experimental group: 14 cases of incomplete abortion took the Chinese medicine composition of Example 3, 9 cases took the Chinese medicine composition of Example 2, 4 cases took the Chinese medicine composition of Example 1, 2 cases took the Chinese medicine composition of Example 4, 3 cases took the Chinese medicine composition of Example 5, 2 cases took the Chinese medicine composition of Example 6, 2 cases took the Chinese medicine composition of Example 7, and 2 cases took the Chinese medicine composition of Example 8;

[0068] In placenta accreta, 4 cases took the Chinese medicine composition of Example 3, 8 cases took the Chinese medicine composition of Example 2, 4 cases took the Chinese medicine composition of Example 2, 3 cases took the Chinese medicine composition of Example 3, 2 cases took the Chinese medicine composition of Example 5, 3 cases took the Chinese medicine composition of Example 6, 2 cases took the Chinese medicine composition of Example 7, 3 cases took the Chinese medicine composition of Example 8, and 1 case took the Chinese medicine composition of Example 9;

[0069] One case of scar pregnancy took the Chinese medicine composition of Example 4;

[0070] The administration method is: ① Orally take the Chinese medicine composition obtained in the corresponding example twice a day, morning and evening, 200 mL / time, one month as a course of treatment, and the efficacy is calculated after 3 courses of treatment. ② If HCG ≥ 300mIU / mL, add mifepristone 50 mg, once a day.

[0071] Control group: Incomplete abortion: mifepristone + uterine curettage;

[0072] Scar pregnancy, placenta accreta: mifepristone + Chanfukang granules or mifepristone + Guizhi Fuling pills.

[0073] (3) Efficacy criteria

[0074] Clinical efficacy evaluation criteria:

[0075] Complete recovery (cured): All placental tissue is naturally discharged or absorbed, color Doppler ultrasound shows that abnormal echoes in the uterine cavity disappear, and the blood β-HCG value drops to the level of non-pregnancy;

[0076] Effective: Most of the placental tissue is eliminated, the residual tissue is organized, and color Doppler ultrasound shows that the residual tissue in the uterus is reduced, the blood flow signal disappears, and the blood β-HCG value decreases significantly or becomes normal;

[0077] Ineffectiveness: occurs during the treatment process, blood β-HCG does not decrease, and the mass does not shrink, and other treatments are required.

[0078] (4) Statistical analysis methods

[0079] The experimental data were expressed as mean ± standard error (mean ± SEM), and n represented the number of samples. Using GraphPad Prism 5 statistical software, paired t-test was used before and after treatment, and P < 0.05 was considered statistically significant.

[0080] (5) Results

[0081] Experimental group: 40 cases of incomplete abortion, 2 cases of giving up treatment midway; 30 cases of placenta accreta; 1 case of scar pregnancy; except for those who gave up treatment, all of them turned negative, the average time for cure was 48 days, and the average time for β-HCG to turn negative was 28 days (the initial β-HCG of the experimental group cases was ≥5mIU / ml to ≤7000mIU / ml, and the initial mass size was 0.8cm until the entire placenta was not expelled).

[0082] Control group: 43 cases of incomplete abortion, 26 cases of placenta accreta, 12 cases of cured incomplete abortion, 1 case of cured placenta accreta, average time 52 days, HCG negative 36 days. (The initial β-HCG of the control group cases was ≥5mIU / ml to ≤6500mIU / ml, and the initial mass size was 0.8cm to the entire placenta).

[0083] None of the experimental group had intrauterine adhesions, and menstruation returned to pre-pregnancy status, and even changed better than before pregnancy. Some of the control group needed additional treatments, such as MTX embryocidal treatment, hysteroscopy, uterine artery embolization, and HIFU, but some of the problems were still not resolved. In addition, the control group had intrauterine adhesions and oligomenorrhea.

[0084] Embodiment 11

[0085] Zhang, 28 years old, was first diagnosed on March 26, 2019, because tissue was found to be residual for 7+ months after induction of labor. She came to the clinic. On August 18, 2018, the patient had an induced labor due to a 6-month gestational deformity. After delivery, the placenta was manually removed due to retained placenta. Before discharge from the hospital after surgery, the curettage failed once. The ultrasound examination still showed residual tissue. So the uterine curettage failed again under the guidance of ultrasound. Later, hysteroscopic electroresection was performed, and the placenta was confirmed to be implanted. The electroresection failed. MR showed that the lesion had always existed. MTX was added to kill the embryo. The blood HCG turned negative, but the lesion did not shrink. The uterine artery embolization was performed, but the lesion still did not shrink. Since the induction of labor, there has been irregular bleeding for 7+ months, and the menstrual period has been extended to 10+ to 20+ days.

[0086] Gynecological examination: vulva (-), vaginal smoothness, a small amount of dark red bloody secretions, smooth cervix, no lifting pain, normal uterus, suspicious tenderness, no obvious swelling or tenderness in the bilateral adnexa. B-ultrasound at an external hospital on February 11, 2019; abnormal echo in the uterine cavity (11×7mm), considering the possibility of placenta accreta.

[0087] From March 26 to April 3, the Chinese medicine composition of Example 1 was used for treatment. The amount obtained by the preparation of Example 1 is one dose, one dose a day, taken twice a day in the morning and evening. B-ultrasound review on April 11, 2019: a small amount of fluid in the uterine cavity. Slightly high echo mass in the uterus, considering the possibility of placenta implantation. No obvious space-occupying lesions were found in the bilateral adnexa. A small amount of pelvic effusion (a 2mm dark area of ​​linear fluid was seen in the uterus, and a slightly high echo mass of 8×6mm was seen on the right side of the uterine fundus, and the boundary with the right muscle layer was unclear. CDFI: punctate blood flow signals were seen inside). On April 11, the original prescription was added with 10g of cinnamon twig, 10g of angelica, 15g of astragalus, and 15g of Scrophularia. 14 days. B-ultrasound on May 13, 2024: no obvious abnormality was found in the uterus. Cyst in the right adnexa. Menstruation returned to normal. In July 2024, the patient had amenorrhea and one pregnancy, and in May 2025, one child was born naturally.

[0088] Example 12

[0089] Chen, 30 years old, first diagnosed on March 3, 2022. The patient had an empty sac at 9+ weeks of pregnancy in March 2020, aborted and had a uterine curettage, had a biochemical pregnancy in February 2021, and got pregnant again in December 2021. The sac was still empty at 8+ weeks of pregnancy, and then had a uterine curettage. She reported that there was no abnormality in chromosomes of both parties, her husband had no thalassemia, and the semen routinely had 98% abnormal sperm. Before this pregnancy, LA241.7, peripheral blood NK cells (CD3-CD16+) 31.78, peripheral blood B cells (CD3-CD19+) 5.89, and antiphospholipid antibodies were negative. There were no abnormalities in plasma proteins S and C, and no obvious abnormalities were found in homocysteine, ANA, AnuA, etc. In October 2021, she was transferred to Donghua Hospital for treatment. Immunoglobulin M: 3.77g / L, coagulation factor II increased by ≥150%, coagulation factor VIII was 34% lower, and the first embryo examination showed that there were no abnormalities in the routine chromosome karyotype analysis of the fetal appearance. Before the second pregnancy, she had received immunotherapy (methylprednisolone, cyclosporine, etc.), and after pregnancy, she had additional treatments (hydroxychloroquine, low molecular weight heparin, aspirin), etc. There was no abnormality in the number of autosomes in the second fetal villi. On January 16, 2022, she had a medical abortion, and reported that the B-ultrasound in an external hospital showed no abnormalities. On February 22, blood BHCG was 86.74IU / L. On February 23, B-ultrasound (2022-02-2316:38) was performed for gynecological color Doppler ultrasound (transvaginal) examination, which showed: abnormal echo group in the uterine cavity: the possibility of residual tissue was considered (the range of irregular mixed echo groups was about 31×13mm, and the boundary with the uterine myometrium was not clear). No obvious space-occupying lesions were found in both appendages.

[0090] The patient had αβ mixed thalassemia, denied any history of infectious diseases such as hepatitis and tuberculosis, any history of chronic diseases such as hypertension, diabetes, heart disease, or any history of surgical trauma. He denied any history of drug or food allergies. He was married and had children.

[0091] Physical examination: generally good, no specialist examination, vulva (-), vaginal candidness, a small amount of white secretions, smooth cervix, no lifting pain, anterior uterus, normal size, no tenderness, bilateral adnexa, no obvious swelling or mass. Dark red tongue, greasy coating, deep and fine pulse.

[0092] From March 3, 2022 to March 24, 2022, the Chinese medicine composition obtained in Example 2 was taken, for a total of 21 doses (the amount prepared in Example 2 is one dose, one dose a day, taken twice a day, morning and evening), and on March 25, 2022, the Chinese medicine composition obtained in Example 8 was used instead, and the medication was taken intermittently, for a total of 15 doses (the amount prepared in Example 8 is one dose, one dose a day, taken twice a day, morning and evening).

[0093] Test results: B-ultrasound (2022-03-31) gynecological color Doppler ultrasound (transvaginal) examination prompts: Abnormal echo mass in the uterine cavity: consider the possibility of residual tissue. A slightly high echo mass can be seen in the uterine cavity, about 31×13mm in size, with clear boundaries and uneven internal echoes. CDFI: Rich blood flow signals are seen inside the above mixed echo mass, RI0.45. Abnormal echo mass in the uterine cavity: consider the possibility of residual tissue.

[0094] Gynecological color Doppler ultrasound (transvaginal) examination (2022-5-20) showed no obvious abnormalities in both uterine adnexa.

[0095] On March 24, blood β-HCG was 30.69mIU / ml, on March 31, blood β-HCG was 23.15mIU / ml, on April 7, blood β-HCG was 17.16mIU / ml, on April 14, blood β-HCG was 11.82mIU / ml, on April 29, blood β-HCG was 9.98mIU / ml, on May 14, blood β-HCG was ≤0.05mIU / ml.

[0096] Example 13

[0097] Patient Guo, 30 years old, was diagnosed with placenta implantation 9 days after induction of labor. On August 25, the patient was induced to have a first-born due to fetal malformation at 25+ weeks of pregnancy. During the operation, the placenta was manually removed due to retained placenta. The placenta was incomplete. B-ultrasound and MR examinations showed placenta implantation and bladder implantation. On the 9th day after the operation, there was still a small amount of vaginal bleeding, no abdominal distension, abdominal pain, frequent urination, urgency, hematuria and other discomforts. The spirit, sleep, appetite, and urination were normal.

[0098] The patient had been trying to get pregnant for 4 years but had not gotten pregnant. B-ultrasound had always shown endometrial polyps. She had hysteroscopic endometrial resection in February 2022. She denied a history of infectious diseases such as hepatitis and tuberculosis, a history of chronic diseases such as hypertension, diabetes, and heart disease, and a history of surgical trauma. She denied a history of drug or food allergies. She is married but has no children. G1P0A1.

[0099] Physical examination: generally good, no specialist examination, vulva (-), vaginal candidness, a small amount of white secretions, smooth cervix, no lifting pain, anterior uterus, normal size, no tenderness, bilateral adnexa, no obvious swelling or mass. Dark red tongue, greasy coating, deep and fine pulse.

[0100] From October 1, 2022 to November 5, 2022, the Chinese medicine composition of Example 6 was taken intermittently for a total of 28 doses (the amount prepared in Example 6 is one dose, one dose per day, taken twice a day, morning and evening).

[0101] 2022.10.7 Vaginal ultrasound: Inhomogeneous echogenic mass in the uterus (the echogenicity of the uterine wall is uneven, and the uterine cavity has an inhomogeneous slightly strong echogenic mass, with a range of about 32×22×35mm, which partially extends to the anterior wall of the uterus (approximately measuring a range of about 20×18mm) and has unclear boundaries with the anterior wall); no obvious space-occupying lesions were found in the bilateral adnexa. A small amount of pelvic effusion.

[0102] 2022.11.5 Vaginal ultrasound: The endometrium had uneven echo, and no obvious abnormalities were found in the bilateral adnexa.

[0103] 2022.12.10 Gynecological color Doppler ultrasound: No obvious space-occupying lesions were found in the uterus and bilateral adnexa. A small amount of pelvic effusion was observed.

[0104] 2022.10.7 Blood BHCG 44.6mIU / ml,

[0105] 2022.10.19blood BHCG≤5mIU / ml.

[0106] Embodiment 14

[0107] Patient Xin, female, 35 years old, gave birth to a baby on August 16, 2020. During delivery, the placenta was manually removed due to retained placenta. Postoperative examination showed that the placenta was missing. 2020.8.12 Vaginal B-ultrasound: postpartum uterus, heterogeneous echo mass in the uterine cavity (about 56×33×25mm, no obvious blood flow signal). 2020.8.17 Initial diagnosis, blood BHCG: 285mIU / ml, treated with Example 3 for two weeks (the amount prepared in Example 3 is one dose, one dose a day, taken twice a day, morning and evening). 2020-9-7 Vaginal ultrasound: postpartum uterus, heterogeneous echo mass in the uterine cavity (about 56×33×25mm, no obvious blood flow signal). 2020-10-8 Vaginal ultrasound: heterogeneous echo mass (about 15mm×6mm×10mm, a small amount of blood flow) was seen in the uterine cavity. Please combine clinical practice. A small amount of pelvic effusion. Example 9 was taken for three weeks (the amount prepared in Example 9 is one dose, one dose a day, taken twice a day, morning and evening). On October 28, 2020, transvaginal ultrasound: a small amount of heterogeneous echo mass (about 7mm×4mm, no blood flow) was seen in the uterine cavity. Example 9 was taken for another week (the amount prepared in Example 9 is one dose, one dose a day, taken twice a day, morning and evening). On November 22, 2020, transvaginal ultrasound: no obvious space-occupying lesions were found in the uterus and bilateral adnexa.

[0108] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for promoting blood circulation, removing blood stasis, eliminating symptoms and dispersing nodules, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 10-30 parts of turtle shell, 10-60 parts of salvia miltiorrhiza, 10-60 parts of red peony root, 10-30 parts of peach kernel, 3-15 parts of leech, 10-30 parts of oldenlandia diffusa, 10-30 parts of trifoliate radix, 10-30 parts of zedoaria, 10-30 parts of zedoaria, 10-30 parts of achyranthes bidentata, 5-15 parts of cinnamon bark, 10-60 parts of motherwort, 5-20 parts of liquorice, 10-30 parts of scutellaria baicalensis, 10-60 parts of luffa, 5-20 parts of thorns of gleditsia sinensis, and 10-30 parts of fritillaria thunbergii.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 15-20 parts of turtle shell, 15-30 parts of salvia miltiorrhiza, 15-20 parts of red peony root, 15-20 parts of peach kernel, 5-10 parts of leech, 15-30 parts of oldenlandia diffusa, 15-20 parts of trifoliate radix, 15-20 parts of zedoaria, 10-15 parts of zedoaria, 10-15 parts of achyranthes bidentata, 5-10 parts of cinnamon bark, 15-30 parts of motherwort, 10-15 parts of liquorice, 15-20 parts of scutellaria baicalensis, 15-30 parts of luffa, 10-15 parts of thorny gleditsia, and 15-30 parts of fritillaria thunbergii.

3. The Chinese medicine composition according to claim 1 or 2, characterized in that: The traditional Chinese medicine composition further comprises the following raw materials in parts by weight: 5-30 parts of angelica sinensis and 10-60 parts of astragalus.

4. The Chinese medicine composition according to claim 1 or 2, characterized in that: The traditional Chinese medicine composition further comprises the following raw materials in parts by weight: 15-30 parts of Scrophularia ningpoensis or 15-30 parts of Radix Trichosanthis.

5. The Chinese medicine composition according to claim 1 or 2, characterized in that: The traditional Chinese medicine composition further comprises the following raw materials in parts by weight: 5-20 parts of cassia twig.

6. The Chinese medicine composition according to claim 1 or 2, characterized in that: The traditional Chinese medicine composition further comprises the following raw materials in parts by weight: 15-30 parts of Radix Trichosanthis and 15-30 parts of Artemisia Capillaris.

7. The method for preparing the Chinese medicine composition according to any one of claims 1 to 6, characterized in that: The method comprises the following steps: mixing water and turtle shell, boiling over high heat and then simmering over low heat for 20-30 minutes, adding other raw materials, boiling and then simmering over low heat for 20-30 minutes.

8. The preparation method according to claim 7, characterized in that: The amount of water added is such that the water surface covers all the raw material mixture by 2cm-5cm.

9. A Chinese medicine preparation for repairing endometrium, treating placenta implantation or treating incomplete abortion, characterized in that: Made from the Chinese medicine composition according to any one of claims 1 to 6 and auxiliary materials.

10. Use of the Chinese medicine composition according to any one of claims 1 to 6 in the preparation of a medicament for repairing endometrium, treating placenta accreta or treating incomplete abortion.