Pingli gynostemma pentaphyllum composition for regulating blood pressure and blood fat and preparation method of Pingli gynostemma pentaphyllum composition

Abstract

The invention discloses a Pingli fiveleaf gynostemma herb composition for regulating blood pressure and blood fat and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. Pingli fiveleaf gynostemma herb, natto powder, red yeast rice, gynura procumbens powder, bitter gourd powder, isomaltooligosacharide, hawthorn fruit powder, codonopsis pilosula powder, lucid ganoderma powder and kudzu vine root powder which are good in blood fat reducing effect are screened out from common blood fat reducing traditional Chinese medicine raw materials and combined, and the blood fat reducing effect of the composition is improved; the composition belongs to a multi-component (combination of different medicines with the same curative effect), a multi-target (different medicines are consistent in purposiveness and strong in pertinence) and a multi-effect composition (the purpose of regulating blood pressure and blood fat can be achieved), has no toxic or side effect and no dependence, can effectively reduce blood pressure, is suitable for being taken by different types of hypertension patients, and has a wide application prospect. Meanwhile, the medicine has the effect of improving the body immunity of the patient, is convenient for long-term treatment of the patient, and is high in safety.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a Pingli Jiaogulan composition for regulating blood pressure and blood lipids and a preparation method thereof. Background Art

[0002] Hypertension refers to a clinical syndrome characterized by an increase in systemic arterial blood pressure (systolic and / or diastolic blood pressure) (systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg), which may be accompanied by functional or organic damage to organs such as the heart, brain, and kidneys. Hypertension is the most common chronic disease and the most important risk factor for cardiovascular and cerebrovascular diseases; diabetes is a group of metabolic diseases characterized by high blood sugar. Hyperglycemia is caused by defects in insulin secretion or impaired biological effects, or both. Long-term high blood sugar in diabetes leads to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves; high uric acid is a metabolic disease caused by a disorder in the metabolism of a substance called purine in the human body, which leads to an increase in uric acid in the blood. The daily production and excretion of uric acid in the body are approximately equal. In terms of production, one-third comes from food, and two-thirds is synthesized by the body itself. The excretion route is one-third from the intestines and two-thirds from the kidneys. The above three symptoms are common symptoms in modern times.

[0003] In order to treat and prevent the above three symptoms, patients often need to take medicines. Most of the medicines currently taken by patients on the market mainly cause stomach irritation, fatigue, dizziness, etc. Long-term use can cause anemia symptoms, and long-term and large-scale use can even cause lactic acidosis, which brings many toxic side effects to the body and causes complications. For this reason, we propose a Pingli Gynostemma pentaphyllum composition for regulating blood pressure and blood lipids and a preparation method thereof. Summary of the invention

[0004] The purpose of the present invention is to solve the problems mentioned in the above background technology, and provide a Pingli Gynostemma pentaphyllum composition for regulating blood pressure and blood lipids and a preparation method thereof.

[0005] In order to achieve the above-mentioned purpose, the present invention specifically adopts the following technical solutions:

[0006] A Pingli Gynostemma pentaphyllum composition for regulating blood pressure and blood lipids, comprising: 110-114 mg of Pingli Gynostemma pentaphyllum, 0.01-0.05 mg of natto powder, 28.00-32.00 mg of red yeast rice, 0.08-0.12 mg of Pingyouju Panax notoginseng powder, 4.00-6.00 mg of bitter melon powder, 110.10-112.10 mg of isomaltooligosaccharide, 9.00-11.00 mg of hawthorn powder, 4.00-6.00 mg of dried ginger powder, 0.4 0~0.60mg, ginkgo fruit powder 0.9~1.1mg, lily powder 27.00~33.00mg, codonopsis powder 0.08~0.12mg, earthworm protein 7.05~9.05mg, snow lotus culture 0.08~0.12mg, Cistanche (desert) powder 0.08~0.12mg, bergamot powder 0.08~0.12mg, Ganoderma lucidum powder 0.08~0.12mg, Pueraria powder 7.00~9.00mg, Polygonatum sibiricum powder 0.08~0.12mg.

[0007] As a further preferred embodiment of the present invention, the composition by weight is as follows: 112.00 mg of Pingli Gynostemma pentaphyllum, 0.05 mg of natto powder, 30.00 mg of red yeast rice, 0.10 mg of Pingwoju Panax notoginseng powder, 5.00 mg of bitter melon powder, 111.10 mg of isomaltooligosaccharide, 10.00 mg of hawthorn powder, 5.00 mg of dried ginger powder, 0.50 mg of Dendrobium officinale powder, 1.00 mg of Ginkgo fruit powder, 30.00 mg of lily powder, 0.10 mg of Codonopsis pilosula powder, 8.05 mg of earthworm protein, 0.10 mg of Saussurea involucrata culture, 0.10 mg of Cistanche deserticola (desert) powder, 0.10 mg of bergamot powder, 0.10 mg of Ganoderma lucidum powder, 8.00 mg of Pueraria powder, and 0.10 mg of Polygonatum sibiricum powder.

[0008] A method for preparing a Pingli Jiaogulan composition for regulating blood pressure and blood lipids comprises the following steps:

[0009] Step 1, pretreatment of raw materials, mixing ingredients according to the weight of the above formula, removing impurities and unqualified raw materials in the Pingli Gynostemma pentaphyllum, red yeast rice and snow lotus culture, and soaking and washing the Pingli Gynostemma pentaphyllum and snow lotus culture in clean water for multiple times, and then drying the Pingli Gynostemma pentaphyllum and snow lotus culture after soaking and washing for standby use;

[0010] Step 2: grinding: placing the dried Pingli Gynostemma pentaphyllum, red yeast rice and snow lotus culture in a grinder and grinding them into powder, sieving them, and drying the powder again;

[0011] Step 3, preparing a mixture 1, placing the dried Pingli Gynostemma pentaphyllum and Saussurea involucrata culture powder in a mixer and mixing them to obtain a mixture 1;

[0012] Step 4, preparing a second mixture, placing natto powder, chrysanthemum and Panax notoginseng powder, bitter melon powder, hawthorn powder, dried ginger powder, dendrobium officinale powder, ginkgo fruit powder, lily powder, codonopsis powder, earthworm protein, Cistanche deserticola powder, bergamot powder, ganoderma lucidum powder, kudzu root powder and polygonatum powder in a mixer and mixing to obtain a second mixture;

[0013] Step 5: Mixing: Mix the mixture 1 and the mixture 2, soak the mixed powder in clean water, filter the soaked medicine in a filter, remove the medicine residue, and obtain a filtrate;

[0014] Step 6: Extraction: placing the filtered mixed solution and isomaltooligosaccharide in an extraction device for extraction;

[0015] Step 7: Preparation: Drying the extracted drug to obtain a solid drug;

[0016] Step 8: Preparation: packaging the prepared drug preparation.

[0017] Furthermore, in the step 1, a centrifuge is used for cleaning, and the soaking time is 4-6 hours.

[0018] Furthermore, in the step 2, the sieving is performed using a 150-200 mesh sieve, the sieving times are greater than 4-6 times, and the drying time is 2-4 hours.

[0019] Furthermore, the mixers in step 3 and step 4 are both BF type drum powder mixers.

[0020] Furthermore, after the filtration is completed in step 5, high temperature sterilization is performed, and the sterilization conditions are 200-300° C. for 3-4 hours.

[0021] Furthermore, in step six, a centrifugal extractor is used for extraction, the extraction temperature is 60-80°C, the pressure is 40-60MPa, and the time is 3-5 hours. After the extraction is completed, the extract is placed in a concentration device for reduced pressure concentration, and the vacuum degree of reduced pressure concentration is 0.08-0.1MPa.

[0022] Furthermore, the solid medicine in step seven is concentrated under reduced pressure to obtain a thick paste.

[0023] Furthermore, the medicine in step eight is a tablet, granule or capsule.

[0024] The beneficial effects of the present invention are as follows:

[0025] 1. The present invention selects Gynostemma pentaphyllum, natto powder, red yeast rice, Gynostemma pentaphyllum powder, bitter melon powder, isomaltooligosaccharide, hawthorn powder, Codonopsis pilosula powder, Ganoderma lucidum powder and Pueraria root powder with good blood lipid lowering effect from common blood lipid lowering Chinese medicine raw materials and combines them to improve the blood lipid lowering effect of the composition.

[0026] 2. The present invention belongs to a multi-component (a combination of different drugs with the same therapeutic effect), multi-target (different drugs have the same purpose and are highly targeted) and multi-effect composition (capable of achieving the purpose of regulating blood pressure and blood lipids), has no toxic side effects, is non-dependent, can effectively lower blood pressure, is suitable for different types of hypertensive patients, and also has the effect of improving the patient's body immunity, is convenient for patients to use for long-term treatment, and has high safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 It is a work flow chart of the present invention. DETAILED DESCRIPTION

[0028] To make the purpose, technical solution and advantages of the embodiments of the present invention more clear, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention.

[0029] See also Figure 1 The present invention provides a Pingli Gynostemma pentaphyllum composition for regulating blood pressure and blood lipids, which is composed of the following weight components: 110-114 mg of Pingli Gynostemma pentaphyllum, 0.01-0.05 mg of natto powder, 28.00-32.00 mg of red yeast rice, 0.08-0.12 mg of Pingyou Ju Panax notoginseng powder, 4.00-6.00 mg of bitter melon powder, 110.10-112.10 mg of isomaltooligosaccharide, 9.00-11.00 mg of hawthorn powder, 4.00-6.00 mg of dried ginger powder, and Dendrobium officinale powder. 0.40~0.60mg, ginkgo nut powder 0.9~1.1mg, lily powder 27.00~33.00mg, codonopsis powder 0.08~0.12mg, earthworm protein 7.05~9.05mg, snow lotus culture 0.08~0.12mg, Cistanche (desert) powder 0.08~0.12mg, bergamot powder 0.08~0.12mg, Ganoderma lucidum powder 0.08~0.12mg, Pueraria powder 7.00~9.00mg, Polygonatum sibiricum powder 0.08~0.12mg.

[0030] Pingli Gynostemma pentaphyllum, according to the 2020 edition of the "Chinese Pharmacopoeia": Nature and flavor and meridians: sweet and bitter in taste, cold in nature, enters the lung and spleen meridians; Functions and indications: resolving phlegm and relieving cough, clearing away heat and detoxifying.

[0031] Natto powder, according to the 2020 edition of the "Chinese Pharmacopoeia": Nature and flavor and meridians: pungent, sweet, slightly bitter, cool in nature, and enters the lung and stomach meridians; Functions and indications: relieving exterior symptoms, relieving restlessness, relieving depressed heat, and detoxifying. It is used for colds, cold and heat headaches, irritability and chest tightness, and insomnia due to deficiency. The sweating effect is quite stable, and sweating does not hurt the yin.

[0032] Red yeast rice, according to the 2020 edition of the "Chinese Pharmacopoeia": Nature and flavor and meridians: sweet, slightly warm, entering the liver, spleen, and large intestine meridians; Functions and indications: promoting blood circulation and removing blood stasis, strengthening the spleen and promoting digestion.

[0033] Panax notoginseng powder, "Chinese Pharmacopoeia 2020 edition" records: nature and flavor and meridians: sweet, slightly bitter, warm, enters the liver and stomach meridians; functions and indications: dispersing blood stasis and stopping bleeding, reducing swelling and relieving pain.

[0034] Bitter melon, according to the 2020 edition of the "Chinese Pharmacopoeia": Nature and flavor and meridians: bitter, cold in nature, enters the heart, spleen, and lung meridians. Functions and indications: clearing away heat, improving eyesight, and detoxifying. It is mainly used to treat summer heat, thirst, diabetes, red eye pain, dysentery, sores, carbuncles, and swelling.

[0035] Isomaltooligosaccharide, according to the 2020 edition of the "Chinese Pharmacopoeia": Nature and flavor and meridians: sweet and warm, entering the lung and stomach meridians, functions and indications: enhancing satiety, providing energy, regulating intestinal flora, etc. It can be added to a variety of foods and is suitable as a food ingredient.

[0036] Hawthorn powder, "Chinese Pharmacopoeia" 2020 edition records: Nature and flavor and meridians: sour, sweet, slightly warm, enters the spleen, stomach, and liver meridians; Functions and indications: helps digestion and strengthens the stomach, promotes qi and disperses blood stasis, resolves turbidity and reduces fat, used for meat stagnation, epigastric distension, diarrhea and abdominal pain, blood stasis and amenorrhea, postpartum blood stasis, stabbing pain in the heart and abdomen, chest pain, hernia pain, and hyperlipidemia.

[0037] Dried ginger, according to the 2020 edition of the "Chinese Pharmacopoeia": Nature and flavor and meridians: pungent, hot, entering the spleen, stomach, kidney, heart, and lung meridians. Functions and indications: warming the middle and dispersing cold, restoring yang and unblocking meridians, warming the lungs and transforming fluid, used for cold pain in the abdomen, vomiting and diarrhea, cold limbs and weak pulse, and wheezing and coughing due to cold fluid.

[0038] Dendrobium candidum, "Chinese Pharmacopoeia" 2020 edition records: Nature and flavor and meridians: sweet, slightly cold. Enter the stomach and kidney meridians, functions and indications: nourish the stomach and produce fluid, nourish yin and clear heat, used for febrile disease, fluid damage, dry mouth and thirst, insufficient stomach yin, poor appetite and retching, persistent deficiency heat after illness, yin deficiency and excessive fire, bone steaming and fatigue fever, blurred vision, and weakness of tendons and bones.

[0039] Ginkgo nut powder, according to the 2020 edition of the "Chinese Pharmacopoeia": Nature and flavor and meridians are sweet, bitter, astringent, and flat. It enters the heart and lung meridians. Functions and indications: promote blood circulation and remove blood stasis, dredge meridians and relieve pain, astringe the lungs and relieve asthma, remove turbidity and reduce lipids. It is used for blood stasis blocking the meridians, chest pain and heart pain, hemiplegia caused by stroke, cough and asthma due to lung deficiency, and hyperlipidemia.

[0040] Lily, according to the 2020 edition of the "Chinese Pharmacopoeia": Nature and flavor and meridians: sweet, cold, entering the heart and lung meridians, Functions and indications: nourishing yin and moistening the lungs, clearing the heart and calming the mind, used for yin deficiency and dry cough, cough with blood due to fatigue, restlessness, palpitations, insomnia, and mental confusion.

[0041] Codonopsis pilosula, "Chinese Pharmacopoeia" 2020 edition records: Nature and flavor and meridians: sweet, flat, enters the spleen and lung meridians, Functions and indications: Strengthens the spleen and lungs, nourishes blood and produces body fluids, used for spleen and lung qi deficiency, poor appetite and fatigue, cough and weak asthma, qi and blood deficiency, sallow complexion, palpitations and shortness of breath, thirst due to loss of body fluids, internal heat and thirst.

[0042] Earthworm protein, "Chinese Pharmacopoeia" 2020 edition records: Nature and flavor and meridians: salty, cold, enters the liver, spleen, and bladder meridians. Functions and indications: clears heat and calms the nerves, dredges the meridians, relieves asthma, and is a diuretic. It is used for high fever and coma, epilepsy and convulsions, joint pain, limb numbness, hemiplegia, lung heat, asthma and cough, edema and oliguria.

[0043] Cistanche deserticola, "Chinese Pharmacopoeia" 2020 edition records: Nature and flavor and meridians: sweet, salty, warm, entering the kidney and large intestine meridians, Functions and indications: tonifying kidney yang, benefiting essence and blood, moistening the intestines and promoting bowel movements, used for kidney yang deficiency, essence and blood deficiency, impotence and infertility, soreness of the waist and knees, weakness of the tendons and bones, and dry intestines and constipation.

[0044] Buddha's hand, "Chinese Pharmacopoeia" 2020 edition records: Nature and flavor and meridians: pungent, bitter, sour, warm, enters the liver, spleen, stomach, and lung meridians. Functions and indications: soothes the liver and regulates qi, harmonizes the stomach and relieves pain, dries dampness and resolves phlegm. It is used for liver and stomach qi stagnation, chest and flank distension and pain, epigastric fullness, loss of appetite and vomiting, and cough with excessive sputum.

[0045] Ganoderma lucidum, "Chinese Pharmacopoeia" 2020 edition records: Nature and flavor and meridians: sweet, flat, enters the heart, lung, liver, and kidney meridians. Functions and indications: tonifies qi and calms the mind, relieves cough and asthma, used for restlessness, insomnia and palpitations, lung deficiency cough and asthma, consumptive disease, shortness of breath, and loss of appetite.

[0046] Pueraria root, according to the 2020 edition of the "Chinese Pharmacopoeia": Nature and flavor and meridians: sweet, pungent, cool, entering the spleen, stomach, and lung meridians. Functions and indications: relieve muscles and reduce fever, promote fluid production and quench thirst, promote rash, raise yang and stop diarrhea, promote blood circulation and activate collaterals, and detoxify alcohol. It is used for exogenous fever and headache, stiff neck and back pain, thirst, diabetes, measles that does not break out, heat dysentery, diarrhea, dizziness and headache, hemiplegia caused by stroke, chest pain and heart pain, and alcohol poisoning.

[0047] Polygonatum sibiricum, "Chinese Pharmacopoeia 2020 edition" records: Nature and flavor and meridians: sweet, flat, enters the spleen, lung, and kidney meridians. Functions and indications: tonifying qi and nourishing yin, strengthening the spleen, moistening the lungs, and benefiting the kidneys. It is used for spleen and stomach qi deficiency, fatigue, insufficient stomach yin, dry mouth and poor appetite, lung deficiency and dry cough, cough with blood due to fatigue, insufficient essence and blood, soreness of the waist and knees, premature graying of hair, internal heat and thirst.

[0048] A method for preparing a Pingli Jiaogulan composition for regulating blood pressure and blood lipids comprises the following steps:

[0049] Step 1, pretreatment of raw materials, mixing ingredients according to the weight of the above formula, removing impurities and unqualified raw materials in the Pingli Gynostemma pentaphyllum, red yeast rice and snow lotus culture, and soaking and washing the Pingli Gynostemma pentaphyllum and snow lotus culture in clean water for multiple times, and then drying the Pingli Gynostemma pentaphyllum and snow lotus culture after soaking and washing for standby use;

[0050] Step 2: grinding: placing the dried Pingli Gynostemma pentaphyllum, red yeast rice and snow lotus culture in a grinder and grinding them into powder, sieving them, and drying the powder again;

[0051] Step 3, preparing a mixture 1, placing the dried Pingli Gynostemma pentaphyllum and Saussurea involucrata culture powder in a mixer and mixing them to obtain a mixture 1;

[0052] Step 4, preparing a second mixture, placing natto powder, chrysanthemum and Panax notoginseng powder, bitter melon powder, hawthorn powder, dried ginger powder, dendrobium officinale powder, ginkgo fruit powder, lily powder, codonopsis powder, earthworm protein, Cistanche deserticola powder, bergamot powder, ganoderma lucidum powder, kudzu root powder and polygonatum powder in a mixer and mixing to obtain a second mixture;

[0053] Step 5: Mixing: Mix the mixture 1 and the mixture 2, soak the mixed powder in clean water, filter the soaked medicine in a filter, remove the medicine residue, and obtain a filtrate;

[0054] Step 6: Extraction: placing the filtered mixed solution and isomaltooligosaccharide in an extraction device for extraction;

[0055] Step 7: Preparation: Drying the extracted drug to obtain a solid drug;

[0056] Step 8: Preparation: packaging the prepared drug preparation.

[0057] Specifically, in the step 1, a centrifuge is used for cleaning, and the soaking time is 4-6 hours; impurities can be prevented from being left in the medicine and affecting the efficacy.

[0058] Specifically, in the step 2, the sieve is sifted with a 150-200 mesh screen, the sifting times are greater than 4-5 times, and the drying time is 2-4 hours; this can achieve the purpose of removing impurities and ensure the quality of subsequent pharmaceutical preparations.

[0059] Specifically, the mixers in step 3 and step 4 are both BF-type drum powder mixers; drum powder mixers can mix materials more evenly through 360-degree all-round mixing to ensure the pharmaceutical effect.

[0060] Specifically, after the filtration is completed in step 5, high temperature sterilization is performed, and the sterilization conditions are 200-300° C. for 3-4 hours; the sterilization function can be achieved to ensure the effect of the drug.

[0061] Specifically, in step six, a centrifugal extractor is used for extraction, the extraction temperature is 60-80°C, the pressure is 40-60MPa, and the time is 3-5 hours. After the extraction is completed, the extract is placed in a concentration device for reduced pressure concentration, and the vacuum degree of reduced pressure concentration is 0.08-0.1MPa. The process is simple and can ensure the pharmaceutical effect.

[0062] Specifically, the solid medicine in step seven is concentrated under reduced pressure to obtain a thick paste.

[0063] Specifically, the medicine in step eight is a tablet, granule or capsule; making the thick paste into tablets, granules or capsules according to different situations can expand the user's choice and improve the eating experience.

[0064] Example 1

[0065] A Pingli Gynostemma pentaphyllum composition for regulating blood pressure and blood lipids, comprising: 110 mg of Pingli Gynostemma pentaphyllum, 0.01 mg of natto powder, 28.00 mg of red yeast rice, 0.08 mg of Pingwoju Panax notoginseng powder, 4.00 mg of bitter melon powder, 110.10 mg of isomaltooligosaccharide, 9.00 mg of hawthorn powder, 4.00 mg of dried ginger powder, 0.40 mg of dendrobium officinale powder, 0.9 mg of ginkgo nut powder, 27.00 mg of lily powder, 0.08 mg of codonopsis pilosula powder, 7.05 mg of earthworm protein, 0.08 mg of snow lotus culture, 0.08 mg of Cistanche deserticola powder, 0.08 mg of bergamot powder, 0.08 mg of ganoderma lucidum powder, 7.00 mg of kudzu root powder, and 0.08 mg of polygonatum sibiricum powder.

[0066] The working principle and use process of the present invention:

[0067] Step 1, pretreatment of raw materials, mixing ingredients according to the weight of the above formula, removing impurities and unqualified raw materials in the Pingli Gynostemma pentaphyllum, red yeast rice and snow lotus culture, and using clean water to soak and wash the Pingli Gynostemma pentaphyllum and snow lotus culture for multiple times, and then drying the Pingli Gynostemma pentaphyllum and snow lotus culture after soaking and washing for standby use; using a centrifuge for cleaning, and the soaking time is 6 hours; it can avoid impurities remaining in the medicine and affecting the efficacy.

[0068] Step 2: Grinding: Grind the dried Pingli Gynostemma pentaphyllum, red yeast rice and snow lotus culture into powder in a grinder, sieve and dry the powder again; sieve with a 200-mesh sieve, sieve more than 5 times, and dry for 4 hours; this can achieve the purpose of removing impurities and ensure the quality of subsequent pharmaceutical preparations.

[0069] Step 3: preparing a mixture 1, placing the dried Gynostemma pentaphyllum and Saussurea involucrata culture powder in a mixer and mixing them to obtain a mixture 1.

[0070] Step 4, preparation of mixture 2, placing natto powder, chrysanthemum procumbentum powder, bitter melon powder, hawthorn powder, dried ginger powder, dendrobium officinale powder, ginkgo fruit powder, lily powder, codonopsis powder, earthworm protein, Cistanche deserticola powder, bergamot powder, ganoderma lucidum powder, kudzu powder and polygonatum powder in a mixer for mixing to obtain mixture 2; the mixer is a BF type drum powder mixer; the drum powder mixer mixes the materials more evenly through 360-degree all-round stirring to ensure the pharmaceutical effect.

[0071] Step 5, mixing, mixing the obtained mixture 1 and mixture 2, soaking the mixed powder in clean water, filtering the soaked medicine in a filter, taking out the medicine residue, and obtaining a filtrate; after filtering, sterilizing by high temperature, the sterilization condition is 300° C., 4 hours; the sterilization function can be achieved to ensure the effect of the medicine.

[0072] Step six, extraction, the filtered mixed solution and oligomalto-oligosaccharide are placed in an extraction device for extraction; a centrifugal extractor is selected for extraction, the extraction temperature is 80°C, the pressure is 60MPa, and the time is 5 hours. After the extraction is completed, the extract is placed in a concentration device for reduced pressure concentration, and the vacuum degree of reduced pressure concentration is 0.1MPa; the process is simple and can ensure the pharmaceutical effect.

[0073] Step seven, preparation, drying the extracted drug to obtain a solid drug; the solid drug is concentrated under reduced pressure to obtain a thick paste.

[0074] Step eight, preparation, packaging the prepared drug preparation; the drug preparation is in the form of tablets, granules or capsules; making the thick paste into tablets, granules or capsules according to different situations can expand the user's choice and improve the eating experience.

[0075] Example 2

[0076] A Pingli Gynostemma pentaphyllum composition for regulating blood pressure and blood lipids, comprising: 114.00 mg of Pingli Gynostemma pentaphyllum, 0.05 mg of natto powder, 32.00 mg of red yeast rice, 0.12 mg of Pingli Gynostemma pentaphyllum powder, and 0.12 mg of bitter melon powder.

[0077] 6.00mg, isomaltooligosaccharide 112.10mg, hawthorn powder 11.00mg, dried ginger powder 6.00mg, dendrobium officinale powder 0.60mg, ginkgo nut powder 1.1mg, lily powder 33.00mg, codonopsis pilosula powder 0.12mg, earthworm protein 9.05mg, snow lotus culture 0.12mg, Cistanche deserticola (desert) powder 0.12mg, bergamot powder 0.12mg, ganoderma lucidum powder 0.12mg, kudzu root powder 9.00mg, polygonatum sibiricum powder 0.12mg.

[0078] The working principle and use process of the present invention:

[0079] Step 1, pretreatment of raw materials, mixing ingredients according to the weight of the above formula, removing impurities and unqualified raw materials in the Pingli Gynostemma pentaphyllum, red yeast rice and snow lotus culture, and using clean water to soak and wash the Pingli Gynostemma pentaphyllum and snow lotus culture for multiple times, and then drying the Pingli Gynostemma pentaphyllum and snow lotus culture after soaking and washing for standby use; using a centrifuge for cleaning, and the soaking time is 5 hours; it can avoid impurities remaining in the medicine and affecting the efficacy.

[0080] Step 2, grinding, placing the above-mentioned dried Pingli Gynostemma pentaphyllum, red yeast rice and snow lotus culture in a grinder and grinding them into powder, sieving, and drying the powder again; sieving with a 200-mesh sieve, the sieving times are greater than 5 times, and the drying time is 3 hours; it can achieve the purpose of removing impurities and ensure the quality of subsequent pharmaceutical preparations.

[0081] Step 3: preparing a mixture 1, placing the dried Gynostemma pentaphyllum and Saussurea involucrata culture powder in a mixer and mixing them to obtain a mixture 1.

[0082] Step 4, preparation of mixture 2, placing natto powder, chrysanthemum procumbentum powder, bitter melon powder, hawthorn powder, dried ginger powder, dendrobium officinale powder, ginkgo fruit powder, lily powder, codonopsis powder, earthworm protein, Cistanche deserticola powder, bergamot powder, ganoderma lucidum powder, kudzu powder and polygonatum powder in a mixer for mixing to obtain mixture 2; the mixer is a BF type drum powder mixer; the drum powder mixer mixes the materials more evenly through 360-degree all-round stirring to ensure the pharmaceutical effect.

[0083] Step 5, mixing, mixing the obtained mixture 1 and mixture 2, soaking the mixed powder in clean water, filtering the soaked medicine in a filter, taking out the medicine residue, and obtaining a filtrate; after filtering, sterilizing by high temperature, the sterilization conditions are 260° C., 3.5 hours; the sterilization function can be achieved to ensure the effect of the medicine.

[0084] Step six, extraction, the filtered mixed solution and oligosaccharide are placed in an extraction device for extraction; a centrifugal extractor is selected for extraction, the extraction temperature is 70°C, the pressure is 50MPa, and the time is 4 hours. After the extraction is completed, the extract is placed in a concentration device for reduced pressure concentration, and the vacuum degree of reduced pressure concentration is 0.09MPa; the process is simple and can ensure the pharmaceutical effect.

[0085] Step seven, preparation, drying the extracted drug to obtain a solid drug; the solid drug is concentrated under reduced pressure to obtain a thick paste.

[0086] Step eight, preparation, packaging the prepared drug preparation; the drug preparation is in the form of tablets, granules or capsules; making the thick paste into tablets, granules or capsules according to different situations can expand the user's choice and improve the eating experience.

[0087] Example 3

[0088] A Pingli Gynostemma pentaphyllum composition for regulating blood pressure and blood lipids, comprising: 112.00 mg of Pingli Gynostemma pentaphyllum, 0.05 mg of natto powder, 30.00 mg of red yeast rice, 0.10 mg of Pingli Gynostemma pentaphyllum powder, and 0.10 mg of bitter melon powder.

[0089] 5.00mg, isomaltooligosaccharide 111.10mg, hawthorn powder 10.00mg, dried ginger powder 5.00mg, dendrobium officinale powder 0.50mg, ginkgo nut powder 1.00mg, lily powder 30.00mg, codonopsis pilosula powder 0.10mg, earthworm protein 8.05mg, snow lotus culture 0.10mg, Cistanche deserticola (desert) powder 0.10mg, bergamot powder 0.10mg, ganoderma lucidum powder 0.10mg, kudzu root powder 8.00mg, polygonatum sibiricum powder 0.10mg.

[0090] The working principle and use process of the present invention:

[0091] Step 1, pretreatment of raw materials, mixing ingredients according to the weight of the above formula, removing impurities and unqualified raw materials in the Pingli Gynostemma pentaphyllum, red yeast rice and snow lotus culture, and using clean water to soak and wash the Pingli Gynostemma pentaphyllum and snow lotus culture for multiple times, and then drying the Pingli Gynostemma pentaphyllum and snow lotus culture after soaking and washing for standby use; using a centrifuge for cleaning, and the soaking time is 4 hours; it can avoid impurities remaining in the medicine and affecting the efficacy.

[0092] Step 2: Grinding: Grind the dried Pingli Gynostemma pentaphyllum, red yeast rice and snow lotus culture into powder in a grinder, sieve and dry the powder again; sieve with a 200-mesh sieve, sieve more than 5 times, and dry for 2 hours; both the purpose of impurity removal and the quality of subsequent pharmaceutical preparation can be achieved.

[0093] Step 3: preparing a mixture 1, placing the dried Gynostemma pentaphyllum and Saussurea involucrata culture powder in a mixer and mixing them to obtain a mixture 1.

[0094] Step 4, preparation of mixture 2, placing natto powder, chrysanthemum procumbentum powder, bitter melon powder, hawthorn powder, dried ginger powder, dendrobium officinale powder, ginkgo fruit powder, lily powder, codonopsis powder, earthworm protein, Cistanche deserticola powder, bergamot powder, ganoderma lucidum powder, kudzu powder and polygonatum powder in a mixer for mixing to obtain mixture 2; the mixer is a BF type drum powder mixer; the drum powder mixer mixes the materials more evenly through 360-degree all-round stirring to ensure the pharmaceutical effect.

[0095] Step 5, mixing, mixing the obtained mixture 1 and mixture 2, soaking the mixed powder in clean water, filtering the soaked medicine in a filter, taking out the medicine residue, and obtaining a filtrate; after filtering, sterilizing by high temperature, the sterilization condition is 200° C., 3 hours; the sterilization function can be achieved to ensure the effect of the medicine.

[0096] Step six, extraction, the filtered mixed solution and oligomalto-oligosaccharide are placed in an extraction device for extraction; a centrifugal extractor is selected for extraction, the extraction temperature is 60°C, the pressure is 40MPa, and the time is 3 hours. After the extraction is completed, the extract is placed in a concentration device for reduced pressure concentration, and the vacuum degree of reduced pressure concentration is 0.08MPa; the process is simple and can ensure the pharmaceutical effect.

[0097] Step seven, preparation, drying the extracted drug to obtain a solid drug; the solid drug is concentrated under reduced pressure to obtain a thick paste.

[0098] Step eight, preparation, packaging the prepared drug preparation; the drug preparation is in the form of tablets, granules or capsules; making the thick paste into tablets, granules or capsules according to different situations can expand the user's choice and improve the eating experience.

[0099] The blood lipid lowering and blood pressure lowering effects of the Pingli Gynostemma pentaphyllum composition for regulating blood pressure and blood lipids provided in Examples 1 to 3 and the comparative example were examined.

[0100] Test method: 110 rats of both sexes were divided into 5 groups, each with 10 rats, namely normal group, high-fat control group, and experimental groups 1 to 3. The normal group was fed only with common basic feed every day, the high-fat control group was fed only with high-fat feed every day, and the experimental groups 1 to 3 were fed with high-fat feed added with Examples 1 to 3 and the provided Pingli Jiaogulan composition for regulating blood pressure and blood lipids every day, and the feeding was continued for 30 days.

[0101] The test results are shown in Table 1:

[0102] Table 1

[0103]

[0104] Table 2

[0105]

[0106] It can be seen from Table 1 and Table 2 that Example 3 is the best solution.

[0107] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A Pingli Gynostemma pentaphyllum composition for regulating blood pressure and blood lipids, characterized in that: According to the following weight Composition: Pingli Gynostemma pentaphyllum 110-114mg, Natto powder 0.01-0.05mg, Red yeast rice 28.00-32.00mg, Pingwoju Panax notoginseng powder 0.08-0.12mg, Bitter melon powder 4.00-6.00mg, Isomaltooligosaccharide 110.10-112.10mg, Hawthorn powder 9.00-11.00mg, Dried ginger powder 4.00-6.00mg, Dendrobium officinale powder 0.40-0.60mg , Ginkgo fruit powder 0.9-1.1mg, lily powder 27.00-33.00mg, Codonopsis powder 0.08-0.12mg, earthworm protein 7.05-9.05mg, snow lotus culture 0.08-0.12mg, Cistanche deserticola (desert) powder 0.08-0.12mg, bergamot powder 0.08-0.12mg, Ganoderma lucidum powder 0.08-0.12mg, Pueraria powder 7.00-9.00mg, Polygonatum powder 0.08- 0.12mg.

2. A Pingli Jiaogulan composition for regulating blood pressure and blood lipids according to claim 1, characterized in that: According to the following weight Ingredients: Pingli Gynostemma pentaphyllum 112.00mg, natto powder 0.05mg, red yeast rice 30.00mg, Pingwoju Panax notoginseng powder 0.10mg, bitter melon powder 5.00mg, isomaltooligosaccharide 111.10mg, hawthorn powder 10.00mg, dried ginger powder 5.00mg, Dendrobium officinale powder 0.50mg, Ginkgo nut powder 1.00mg, lily powder 30.00mg, Codonopsis pilosula powder 0.10mg, earthworm protein 8.05mg, snow lotus culture 0.10mg, Cistanche deserticola powder 0.10mg, bergamot powder 0.10mg, Ganoderma lucidum powder 0.10mg, Pueraria powder 8.00mg, Polygonatum sibiricum powder 0.10mg.

3. A method for preparing a Pingli Jiaogulan composition for regulating blood pressure and blood lipids as claimed in claim 1, characterized in that: The method comprises the following steps: Step 1, pretreatment of raw materials, mixing ingredients according to the weight of the above formula, removing impurities and unqualified raw materials in the Pingli Gynostemma pentaphyllum, red yeast rice and snow lotus culture, and soaking and washing the Pingli Gynostemma pentaphyllum and snow lotus culture in clean water for multiple times, and then drying the Pingli Gynostemma pentaphyllum and snow lotus culture after soaking and washing for standby use; Step 2: grinding: placing the dried Pingli Gynostemma pentaphyllum, red yeast rice and snow lotus culture in a grinder and grinding them into powder, sieving them, and drying the powder again; Step 3, preparing a mixture 1, placing the dried Pingli Gynostemma pentaphyllum, red yeast rice and snow lotus culture powder in a mixer and mixing them to obtain a mixture 1; Step 4, preparing a second mixture, placing natto powder, chrysanthemum and Panax notoginseng powder, bitter melon powder, hawthorn powder, dried ginger powder, dendrobium officinale powder, ginkgo fruit powder, lily powder, codonopsis powder, earthworm protein, Cistanche deserticola powder, bergamot powder, ganoderma lucidum powder, kudzu root powder and polygonatum powder in a mixer and mixing to obtain a second mixture; Step 5: Mixing: Mix the mixture 1 and the mixture 2, soak the mixed powder in clean water, filter the soaked medicine in a filter, remove the medicine residue, and obtain a filtrate; Step 6: Extraction: placing the filtered mixed solution and isomaltooligosaccharide in an extraction device for extraction; Step 7: Preparation: Drying the extracted drug to obtain a solid drug; Step 8: Preparation: packaging the prepared drug preparation.

4. The method for preparing a Pingli Jiaogulan composition for regulating blood pressure and blood lipids according to claim 3, characterized in that: In the step 1, a centrifuge is used for cleaning, and the soaking time is 4-6 hours.

5. The method for preparing a Pingli Jiaogulan composition for regulating blood pressure and blood lipids according to claim 3, characterized in that: In the step 2, the sieving is performed using a 150-200 mesh screen, the sieving times are greater than 4-6 times, and the drying time is 2-4 hours.

6. The method for preparing the Pingli Jiaogulan composition for regulating blood pressure and blood lipids according to claim 3, characterized in that: The mixers in step 3 and step 4 are both BF type drum powder mixers.

7. The method for preparing a Pingli Jiaogulan composition for regulating blood pressure and blood lipids according to claim 3, characterized in that: After the filtration in step 5 is completed, high temperature sterilization is performed, and the sterilization conditions are 200-300° C. for 3-4 hours.

8. The method for preparing the Pingli Jiaogulan composition for regulating blood pressure and blood lipids according to claim 3, characterized in that: In step six, a centrifugal extractor is used for extraction. The extraction temperature is 60-80° C., the pressure is 40-60 MPa, and the time is 3-5 hours. After the extraction is completed, the extract is placed in a concentration device for reduced pressure concentration. The vacuum degree of the reduced pressure concentration is 0.08-0.1 MPa.

9. The method for preparing a Pingli Jiaogulan composition for regulating blood pressure and blood lipids according to claim 3, characterized in that: The solid medicine in step seven is concentrated under reduced pressure to obtain a thick paste.

10. The method for preparing the Pingli Jiaogulan composition for regulating blood pressure and blood lipids according to claim 3, characterized in that: The medicine in step eight is a tablet, granule or capsule.

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