Use of 1 Hz rhythmic mechanical sensory stimulation in devices for promoting sleep

Abstract

The invention provides application of 1Hz rhythmic mechanical sensation stimulation in sleep promoting equipment, and belongs to the technical field of sleep promoting equipment development. Rhythmic mechanical sensation stimulation with the frequency of 1Hz and the amplitude of 30mm provided by the invention can obviously prolong the non-fast eye movement sleep time, promote sleep and improve the sleep quality. The technical effects of promoting sleep and improving sleep quality can be achieved without using any medicine, and the traditional Chinese medicine composition has no side effect and is more controllable.

Description

Technical Field

[0001] The present invention relates to the technical field of sleep-promoting equipment development, and in particular to the application of 1 Hz rhythmic mechanical sensation stimulation in sleep-promoting equipment. Background Art

[0002] Sleep provides guarantee for the operation of important physiological functions such as growth and development, energy metabolism, immune function, learning and memory. Therefore, sleep disorders bring serious harm to human life and work, and become an increasingly serious social problem. The incidence of clinical insomnia has been rising year by year, seriously affecting people's quality of life and work efficiency. Long-term insomnia can lead to memory disorders, depression, physical and intellectual retardation, low immune function, aggravate other diseases or induce the onset of original diseases (such as cardiovascular and cerebrovascular accidents). Tranquilizers are currently an important means of treating insomnia, but they are prone to cause addiction, tolerance, residual effects, changes in sleep patterns and other adverse reactions. There is still a lack of effective methods for the treatment of insomnia.

[0003] The sleeping pills currently used in clinical practice induce sleep waves that are significantly different from physiological sleep waves, suggesting that sleeping pills may change the body's normal sleep patterns and the brain does not actually get enough rest. Patients often experience drowsiness, dizziness, fatigue and other symptoms the next morning after taking the pills. Long-term use can also lead to drug resistance, and physiological and psychological dependence. Summary of the invention

[0004] In view of this, the purpose of the present invention is to provide an application of 1 Hz rhythmic mechanical sensation stimulation in a device for promoting sleep. The rhythmic mechanical sensation stimulation with a frequency of 1 Hz and an amplitude of 30 mm proposed in the present invention can promote sleep and improve sleep quality.

[0005] In order to achieve the above object, the present invention provides the following technical solutions:

[0006] One of the technical solutions of the present invention is a method for promoting sleep for non-disease diagnosis and treatment purposes, in which a horizontal reciprocating rocking bed generates rhythmic mechanical sensory stimulation with a frequency of 1 Hz and an amplitude of 30 mm.

[0007] The second technical solution of the present invention is a device for promoting sleep and improving sleep quality, comprising a horizontal reciprocating rocking bed, which can generate rhythmic mechanical sensory stimulation with a frequency of 1 Hz and an amplitude of 30 mm.

[0008] The third technical solution of the present invention is the application of rhythmic mechanical sensation stimulation with a frequency of 1 Hz and an amplitude of 30 mm in promoting sleep and improving sleep quality for non-disease diagnosis and treatment purposes.

[0009] The present invention discloses the following technical effects:

[0010] The rhythmic mechanical sensation stimulation with a frequency of 1 Hz and an amplitude of 30 mm proposed by the present invention can significantly increase the non-rapid eye movement sleep time, promote sleep and improve sleep quality.

[0011] The present invention can achieve the technical effect of promoting sleep and improving sleep quality without using any drugs, has no side effects, and is more controllable. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0013] Figure 1 This is a time course curve of the significant increase in NREM by continuous 12-hour 1 Hz mechanical stimulation in Example 1; in the figure, the black hollow circles and the red hollow circles represent the amount of NREM sleep per hour in the baseline group and the 1 Hz stimulation group, respectively; the values ​​are mean ± standard error, n = 13; compared with the baseline group, *P < 0.05, **P < 0.01, and the paired t-test was used as the statistical method.

[0014] Figure 2 The amount of NREM sleep for 12 hours of rhythmic mechanical stimulation in Example 1; in the figure, black, green, red and blue represent the total amount of NREM sleep for 12 hours under baseline, 0.5Hz, 1Hz and 2Hz stimulation, respectively; the values ​​are mean ± standard error; the number of animals corresponding to baseline, 0.5Hz, 1Hz and 2Hz are 10, 8, 13 and 8, respectively. Compared with the baseline group, **P<0.01, and the statistical method used was analysis of variance. DETAILED DESCRIPTION

[0015] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but should be understood as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0016] It should be understood that the terms described in the present invention are only for describing a particular embodiment and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that each intermediate value between the upper and lower limits of the scope is also specifically disclosed. The intermediate value in any stated value or stated range, and each smaller range between any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0017] Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as those generally understood by those skilled in the art. Although the present invention describes only preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of a conflict with any incorporated document, the content of this specification shall prevail.

[0018] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present invention description without departing from the scope or spirit of the present invention. Other embodiments derived from the present invention description will be apparent to the skilled artisan. The present invention description and examples are exemplary only.

[0019] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0020] The present invention shows that 1Hz rhythmic mechanical stimulation can promote sleep and improve sleep quality. Rhythmic mechanical stimulation, also known as vibration, is also called rhythmic mechanosensory stimulation in English, also known as rocking, which is one of the non-invasive sensory stimulations and can be used as a non-drug treatment for sleep disorders.

[0021] The rhythmic mechanical stimulation used in the present invention is generated by a horizontal reciprocating shaker with a vibration amplitude of 30 mm. By using different frequency stimulations to explore its sleep-promoting effect, it was found that 1 Hz rhythmic mechanical stimulation can significantly promote non-rapid eye movement (NREM) sleep and improve sleep quality.

[0022] In order to better understand the present invention, the content of the present invention is further explained below in conjunction with the embodiments, but the content of the present invention is not limited to the following embodiments.

[0023] Example 1

[0024] Effects of rhythmic mechanosensory stimulation of different frequencies on sleep

[0025] Experimental Materials

[0026] Male C57BL / 6J mice, SPF grade, 10-13 weeks old, 23-25g, were purchased from Shanghai Experimental Animal Center, Chinese Academy of Sciences. Rearing conditions: room temperature (22±1)℃, humidity (50±10)%, 12-h light-dark rhythmic cycle, free access to water and food. A reciprocating shaking shaker with an amplitude of 30 mm and adjustable frequency.

[0027] Experimental methods

[0028] Electrodes for recording EEG and EMG were installed on the surface of the mouse skull. The experiment was conducted after the animals recovered for 10 days, and the electrode connection wires were connected 3 days before the experiment. The experimental groups were: control group (no vibration stimulation under the same recording environment); 0.5Hz stimulation group; 1Hz stimulation group; 2Hz stimulation group. The mice were given continuous mechanical sensory stimulation for 12 hours during the dark period.

[0029] The EEG and EMG signals of mice were amplified, filtered, and converted into digital signals by the sleep bioanalysis system, and then recorded using SleepSign software (Kissei Comtec, Nagano, Japan). The recording started at 19:00 and lasted for 48 hours. 19:00 on the first day was used as a control, and rhythmic mechanical stimulation of different frequencies was given at 19:00 on the second day for 12 hours. After the EEG / EMG recording was completed, SleepSign analysis software was used to automatically scan and identify wakefulness (Wake), NREM, and rapid eye movement sleep (REM) according to the unified set standards with 4s as the analysis unit. After the automatic scanning was completed, manual inspection was performed and corrections were made if necessary.

[0030] Experimental Results

[0031] To detect the effect of rhythmic mechanical stimulation on sleep, 0.5Hz, 1Hz and 2Hz vibration stimulation were used to observe the effect on sleep-wake. Compared with the baseline group, the 1Hz vibration stimulation group significantly increased the NREM sleep of mice during the dark period, and the effect lasted for 6h ( Figure 1 ). There was no difference in the amount of NREM sleep during the 12-hour dark period between the 0.5 Hz and 2 Hz groups compared with the baseline group ( Figure 2 ). 1Hz vibration stimulation significantly increased the total amount of NREM sleep in mice during the dark period. The above suggests that 1Hz vibration stimulation may be the best stimulation frequency for promoting sleep.

[0032] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A method for promoting sleep and improving sleep quality for non-disease diagnosis and treatment purposes, characterized in that: Rhythmic mechanical stimulation with a frequency of 1 Hz and an amplitude of 30 mm was generated by a horizontal reciprocating shaker.

2. A device for promoting sleep and improving sleep quality, characterized in that: The invention comprises a horizontal reciprocating shaker which can generate rhythmic mechanical stimulation with a frequency of 1 Hz and an amplitude of 30 mm.

3. The application of rhythmic mechanical sensory stimulation with a frequency of 1 Hz and an amplitude of 30 mm in promoting sleep and improving sleep quality for non-disease diagnosis and treatment purposes.

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