Targeted drug delivery device

Abstract

The invention discloses a targeted drug delivery device which comprises a delivery hose, a drug adding opening, a pressurizing opening and a directional drug delivery assembly. The conveying hose is provided with an input end and an output end, the input end of the conveying hose is arranged outside a blood vessel, the output end of the conveying hose is arranged in the blood vessel, the medicine adding opening and the pressurizing opening are formed in the input end of the conveying hose, and the directional medicine conveying assembly is arranged at the output end of the conveying hose; wherein the directional medicine feeding assembly is driven by blood flowing to move in blood vessels and used for releasing medicine to the focus position.

Description

Technical Field

[0001] The present invention relates to the technical field of drug delivery, and in particular to a targeted drug delivery device. Background Art

[0002] A targeted drug delivery device is a device that can specifically deliver drugs to specific parts of the body (such as tumor tissue, inflammatory areas, etc.). Its main purpose is to increase the bioavailability of drugs and reduce the distribution of drugs in non-target areas, thereby reducing side effects and improving treatment effects.

[0003] However, during the process of targeted drug release, the drug is naturally released, causing a large amount of drug to be lost in the blood, resulting in a significant reduction in the amount of drug acting on the blood vessel wall at the lesion site, thus affecting the treatment effect.

[0004] Therefore, it is necessary to invent a targeted drug delivery device to solve the above problems. Summary of the invention

[0005] In view of the above problems, the present invention provides a targeted drug delivery device, which solves the problem of low effective utilization rate of targeted drugs.

[0006] The technical solution adopted by the present invention is: comprising a delivery hose, a drug adding port, a pressurizing port and a directional drug delivery assembly; the delivery hose has an input end and an output end, wherein the input end is arranged outside the blood vessel, and the output end is arranged inside the blood vessel, the drug adding port and the pressurizing port are respectively arranged at the input end of the delivery hose, and the directional drug delivery assembly is arranged at the output end of the delivery hose; The directional drug delivery component moves in the blood vessel driven by the blood flow to release drugs to the lesion site.

[0007] Further, as a preference, the directional drug delivery component includes an opening and closing component including an arc-shaped baffle and an elastic isolation membrane; the arc-shaped baffle is arranged in plurality on a circle and coaxially arranged on the periphery of the closed tube, magnetic blocks with the same magnetic properties are respectively arranged at both ends of the arc-shaped baffle, and the two magnetic blocks on two adjacent arc-shaped baffles have opposite magnetic properties, circular built-in grooves are respectively opened along the circumferential direction between the two magnetic blocks on the mutually close side of the two adjacent arc-shaped baffles, and a telescopic strip is commonly connected in two adjacent circular built-in grooves, and the telescopic strip has a certain elastic deformation ability, which is used to reset two adjacent magnetic blocks, and two elastic isolation membranes are arranged in a ring shape, one end of the elastic isolation membrane is sealed and fixed to the outer wall of the sealing tube, and the other end is sealed and fixed to the end of the plurality of arc-shaped baffles.

[0008] Furthermore, as a preference, the directional drug delivery assembly also includes a drug delivery tube and an air delivery tube; one end of the drug delivery tube is connected to the drug adding port, and the other end is sealed and fixed and passes through the blocking tube and is arranged in the expansion space; one end of the air delivery tube is connected to the pressurizing port, and the other end is sealed and fixed and passes through the blocking tube and is arranged in the expansion space.

[0009] Further, as a preference, the opening and closing component includes an arc-shaped baffle and an elastic isolation membrane; the arc-shaped baffle is arranged in plurality on a circumference and coaxially arranged on the periphery of the closed tube, magnetic blocks with the same magnetic properties are arranged at both ends of the arc-shaped baffle respectively, and the two magnetic blocks on two adjacent arc-shaped baffles have opposite magnetic properties, and a telescopic strip is connected between the two magnetic blocks on the mutually close side of two adjacent arc-shaped baffles, and the telescopic strip is used to reset the two adjacent magnetic blocks, and two elastic isolation membranes are arranged in a ring shape, one end of the elastic isolation membrane is sealed and fixed to the outer wall of the sealing tube, and the other end is sealed and fixed to the ends of the plurality of arc-shaped baffles.

[0010] Furthermore, as a preference, a plurality of air holes are provided on the sealing tube, an exhaust bag is sealed in the air hole, the exhaust bag is retractable, and an air-permeable membrane is sealed at the open end of the exhaust bag.

[0011] Furthermore, preferably, a one-way exhaust valve is provided between the blocking tube and the expansion space.

[0012] Furthermore, as a preference, the drug delivery tube and the gas delivery tube are both configured as soft tubes.

[0013] Advantages of the present invention: In the present invention, during the expansion process, the multiple arc-shaped baffles can stretch the elastic isolation membranes on both sides thereof, thereby temporarily blocking the blood flowing toward the elastic isolation membranes, thereby slowing down the blood flow rate in the targeted drug release space, reducing the excessive loss rate of targeted drugs with the blood, and thus improving the effective use rate of targeted drugs; 2 During the release process of targeted drugs, the exhaust bag will perform an exhaust action, so that the released gas can expel all the targeted drugs in the expansion space, avoiding the targeted drugs from remaining in the expansion space and improving the effective utilization rate of the targeted drugs; at the same time, the exhaust bag can provide a certain amount of kinetic energy for the released targeted drugs, so that the drugs can overcome the impact energy of the blood, thereby further reducing the loss rate of the targeted drugs and thus improving the effective utilization rate of the targeted drugs.

[0014] In addition to the above-described purposes, features and advantages, the present invention has other purposes, features and advantages. The present invention will be further described in detail with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The drawings constituting a part of this application are used to provide a further understanding of the present invention. The illustrative embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute improper limitations on the present invention.

[0016] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 is a cross-sectional view of a directional medicine delivery assembly of the present invention; Figure 3 It is an enlarged view of point A of the present invention; Figure 4 is a side cross-sectional view of a directional medicine delivery assembly of the present invention; Figure 5 This is a working state diagram of the directional medicine delivery component of the present invention.

[0017] Figure numerals: 1. Delivery hose; 2. Dosing port; 3. Pressurization port; 4. Directional drug delivery assembly; 41. Blocking tube; 42. Positioning ring; 43. Closing tube; 44. Opening and closing component; 45. Drug delivery tube; 46. Air delivery tube; 441. Arc-shaped baffle; 442. Elastic isolation membrane; 443. Magnetic block; 444. Telescopic strip; 431. Exhaust bag; 432. Breathable membrane; 5. Expansion space. DETAILED DESCRIPTION

[0018] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0019] In the description of the present invention, it is necessary to understand that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship are based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0020] refer to Figures 1 to 5 A targeted drug delivery device comprises a delivery hose 1, a drug adding port 2, a pressurizing port 3 and a directional drug delivery component 4; the delivery hose 1 has an input end and an output end, wherein the input end is arranged outside a blood vessel, and the output end is arranged inside the blood vessel, the drug adding port 2 and the pressurizing port 3 are respectively arranged at the input end of the delivery hose 1, and the directional drug delivery component 4 is arranged at the output end of the delivery hose 1; The directional drug delivery component 4 is capable of moving within the blood vessel to release drugs to the lesion site.

[0021] It should be explained that the delivery hose 1 is configured to be of sufficient length so that the directional drug delivery assembly 4 can reach the target location; In addition, the pressurizing port 3 can inject a certain amount of oxygen into the directional drug delivery component 4 from outside the blood vessel, thereby achieving a pressurizing effect.

[0022] As a preferred embodiment, the directional drug delivery assembly 4 includes a blocking tube 41, a positioning ring 42, a blocking tube 43 and an opening and closing component 44; the blocking tube 41 has an open end and a sealed end, the open end of the blocking tube 41 is connected to the output end of the delivery hose 1, the positioning ring 42 is arranged on both sides of the blocking tube 41, and is used to specifically locate the lesion position, the blocking tube 43 is sealed and fixed on the outer wall of the blocking tube 41, and the opening and closing component 44 is arranged on the outer wall of the blocking tube 41 and is located on the periphery of the blocking tube 43; A gap expansion space 5 is formed between the sealing tube 43 and the opening and closing component 44 .

[0023] It should be noted that the blocking tube 41 is configured as a hard tube as a carrier, and the positioning ring 42 is designed to be a carrier material with bio-responsiveness. These materials can undergo physical or chemical changes under the specific environment of the lesion site (different pH values), so that the specific location of the lesion can be locked through an external control unit, thereby locking the length of the delivery hose 1 extending into the blood vessel, so as to facilitate the delivery of drugs to the target lesion.

[0024] As a preferred embodiment, the directional drug delivery component 4 also includes a drug delivery tube 45 and an air delivery tube 46; one end of the drug delivery tube 45 is connected to the drug adding port 2, and the other end is sealed and fixed and passes through the blocking tube 41 and is arranged in the expansion space 5; one end of the air delivery tube 46 is connected to the pressurizing port 3, and the other end is sealed and fixed and passes through the blocking tube 41 and is arranged in the expansion space 5.

[0025] That is, the targeted drug can be continuously released into the expansion space 5 through the drug delivery tube 45; Furthermore, oxygen can be injected into the expansion space 5 through the gas supply pipe 46 , so that the pressure in the expansion space 5 can be increased.

[0026] As a preferred embodiment, the opening and closing component 44 includes an arc-shaped baffle 441 and an elastic isolation membrane 442; the arc-shaped baffle 441 is arranged with multiple pieces around the circumference and coaxially arranged on the periphery of the closed tube 43, and magnetic blocks 443 with the same magnetic properties are arranged at both ends of the arc-shaped baffle 441, and the two magnetic blocks 443 on the two adjacent arc-shaped baffles 441 have opposite magnetic properties, and circular built-in grooves are respectively opened along the circumferential direction between the two magnetic blocks 443 on the side close to each other of the two adjacent arc-shaped baffles 441, and a telescopic strip 444 is commonly connected in the two adjacent circular built-in grooves, and the telescopic strip 444 has a certain elastic deformation ability, which is used to reset the two adjacent magnetic blocks 443, and the elastic isolation membrane 442 is arranged with two pieces and is arranged in a ring shape, and one end of the elastic isolation membrane 442 is sealed and fixed on the outer wall of the blocking tube 41, and the other end is sealed and fixed to the ends of the multiple arc-shaped baffles 441.

[0027] For explanation, see Figure 4 , a plurality of arc-shaped baffles 441 are attracted to each other by two adjacent magnetic blocks 443 to form a closed ring; Moreover, the diameter of the closed ring body is much smaller than the inner diameter of the blood vessel, that is, the overall directional drug delivery component 4 can move smoothly in the blood vessel.

[0028] It should also be explained that the deformation pressure of the telescopic strip 444 is much smaller than the attraction between the magnetic blocks 443 .

[0029] Specifically, when the air pressure in the expansion space 5 increases to a value greater than the attraction between the magnetic blocks 443, the multiple arc-shaped baffles 441 will expand rapidly, thereby forming channels between the multiple arc-shaped baffles 441, and the targeted drug will be released from the channel between two adjacent arc-shaped baffles 441; Furthermore, during the expansion process, the multiple arc-shaped baffles 441 can stretch the elastic isolation membranes 442 on both sides thereof. Therefore, the elastic isolation membranes 442 can expand in a short time, temporarily blocking the blood flowing toward the elastic isolation membranes 442, thereby slowing down the blood flow rate in the targeted drug release space, reducing the rate of excessive targeted drug loss with the blood, and allowing the released targeted drugs to act on the lesion location, thereby improving the effective utilization rate of the targeted drugs.

[0030] As a preferred embodiment, the sealing tube 43 is provided with a plurality of air holes, and an exhaust bag 431 is sealed in the air hole. The exhaust bag 431 is retractable, and an air-permeable membrane 432 is sealed at the open end of the exhaust bag 431 .

[0031] The air-permeable membrane 432 only allows gas to enter the exhaust bag 431 .

[0032] It should be noted that when the air pressure in the expansion space 5 increases, the volume of the exhaust bag 431 increases first, realizing the energy storage process of the exhaust bag 431. When the exhaust bag 431 expands to a peak value, the energy storage process of the exhaust bag 431 ends. Thereafter, the air pressure in the expansion space 5 continues to increase until the air pressure in the expansion space 5 rises to a certain threshold value, that is, when the multiple arc-shaped baffles 441 expand, the medicine in the expansion space 5 is released.

[0033] Specifically, during the release of the targeted drug, the air pressure in the expansion space 5 is reduced, and the exhaust bag 431 in the expanded state shrinks to the initial state, so that the exhaust bag 431 performs an exhaust action, so that the released gas can completely discharge the targeted drug in the expansion space 5, thereby preventing the targeted drug from remaining in the expansion space 5 and improving the effective use rate of the targeted drug; In addition, the gas released by the exhaust bag 431 can provide a certain amount of kinetic energy for the released targeted drug, so that the drug can overcome the impact energy of the blood, thereby further reducing the loss rate of the targeted drug and further improving the effective use rate of the targeted drug.

[0034] Moreover, after completing a targeted drug release, the telescopic strip 444 pulls the arc-shaped baffle 441 to return to its initial state under the action of the reset force, thereby forming the expansion space 5 again. Therefore, the device can uniformly treat multiple lesions along the blood vessels without the need for repeated removal and replacement, thereby improving the treatment efficiency.

[0035] As a preferred embodiment, a one-way exhaust valve is further provided between the blocking tube 41 and the expansion space 5 .

[0036] Specifically, other gases in the expansion space 5 are first discharged into the blocking tube 41 through the gas supply pipe 46 via the one-way exhaust valve, and then the targeted drug is introduced into the expansion space 5 to avoid harmful gases from having adverse effects on the human body when releasing the targeted drug.

[0037] As a preferred embodiment, the drug delivery tube 45 and the gas delivery tube 46 are both configured as soft tubes.

[0038] Specifically, during implementation, the lesion position is first located by the positioning ring 42, and then the targeted drug is introduced into the expansion space 5 through the drug delivery tube 45, and oxygen is introduced into the expansion space 5 through the air delivery tube 46. The introduced oxygen first expands the exhaust bag 431 to store energy. When the exhaust bag 431 has completed energy storage, the air pressure in the expansion space 5 continues to increase until the air pressure in the expansion space 5 is greater than the attraction between the magnetic blocks 443. The multiple arc-shaped baffles 441 will expand rapidly, thereby forming channels between the multiple arc-shaped baffles 441. At this time, the air pressure in the expansion space 5 is reduced instantly, and the gas released by the exhaust bag 431 can provide a certain amount of kinetic energy for the released targeted drug, so that the drug can overcome the impact energy of the blood and reach the target lesion directly, thereby reducing the loss rate of the targeted drug. After the drug is released, the attraction between the magnetic blocks 443 and the reset force between the telescopic strips 444 restore the multiple arc-shaped baffles 441 to their initial state, thereby the expansion space 5 is formed again for reuse.

[0039] The above description is only a preferred embodiment of the rectangular groove of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A targeted drug delivery device, characterized in that: It comprises a delivery hose (1), a drug adding port (2), a pressurizing port (3) and a directional drug delivery assembly (4); the delivery hose (1) has an input end and an output end, wherein the input end is arranged outside a blood vessel, and the output end is arranged inside the blood vessel; the drug adding port (2) and the pressurizing port (3) are respectively arranged at the input end of the delivery hose (1), and the directional drug delivery assembly (4) is arranged at the output end of the delivery hose (1); The directional drug delivery component (4) moves within the blood vessel driven by blood flow, and is used to release drugs at the lesion site.

2. A targeted drug delivery device according to claim 1, characterized in that: The directional drug delivery assembly (4) comprises a blocking tube (41), a positioning ring (42), a sealing tube (43) and an opening and closing component (44); the blocking tube (41) has an open end and a sealing end, the open end of the blocking tube (41) is connected to the output end of the delivery hose (1), the positioning ring (42) is arranged on both sides of the blocking tube (41) and is used to specifically locate the lesion position, the sealing tube (43) is sealed and fixed on the outer wall of the blocking tube (41), and the opening and closing component (44) is arranged on the outer wall of the blocking tube (41) and is located on the periphery of the blocking tube (43); A gap expansion space (5) is formed between the sealing tube (43) and the opening and closing component (44).

3. A targeted drug delivery device according to claim 2, characterized in that: The directional drug delivery assembly (4) further comprises a drug delivery tube (45) and an air delivery tube (46); one end of the drug delivery tube (45) is connected to the drug adding port (2), and the other end is sealed and fixed and passes through the blocking tube (41) to be arranged in the expansion space (5); one end of the air delivery tube (46) is connected to the pressurizing port (3), and the other end is sealed and fixed and passes through the blocking tube (41) to be arranged in the expansion space (5).

4. A targeted drug delivery device according to claim 2, characterized in that: The opening and closing component (44) comprises an arc-shaped baffle (441) and an elastic isolation membrane (442); the arc-shaped baffle (441) is provided with a plurality of pieces on the circumference and is coaxially arranged on the periphery of the closed tube (43); magnetic blocks (443) with the same magnetic properties are respectively arranged at both ends of the arc-shaped baffle (441); the two magnetic blocks (443) on two adjacent arc-shaped baffles (441) have opposite magnetic properties; and the two magnetic blocks (443) on the mutually adjacent sides of the two adjacent arc-shaped baffles (441) are arranged on the same side. Circular built-in grooves are respectively provided between the force blocks (443) along the circumferential direction, and a telescopic strip (444) is commonly connected in two adjacent circular built-in grooves. The telescopic strip (444) has a certain elastic deformation capability and is used to reset two adjacent magnetic force blocks (443). Two elastic isolation membranes (442) are provided and arranged in an annular shape. One end of the elastic isolation membrane (442) is sealed and fixed to the outer wall of the blocking tube (41), and the other end is sealed and fixed to the ends of the plurality of arc-shaped baffles (441).

5. A targeted drug delivery device according to claim 4, characterized in that: The closed tube (43) is provided with a plurality of air holes, and an exhaust bag (431) is sealed in the air hole. The exhaust bag (431) is retractable, and an air-permeable membrane (432) is sealed at the open end of the exhaust bag (431).

6. A targeted drug delivery device according to claim 3, characterized in that: A one-way exhaust valve is also provided between the blocking tube (41) and the expansion space (5).

7. A targeted drug delivery device according to claim 3, characterized in that: The drug delivery tube (45) and the gas delivery tube (46) are both configured as soft tubes.

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