Balloon nasogastric tube applying silver nano hydrogel coating

Abstract

The invention belongs to the technical field of stomach tubes, and particularly relates to a balloon nasogastric tube applying a silver nano hydrogel coating. Comprising a main tube and a balloon fixedly arranged outside the main tube, the main tube is a hollow hose, the balloon is connected with an inflation tube in a penetrating mode, an inflation valve is arranged on the inflation tube and used for inflating or deflating the balloon, a drainage head is connected to the main tube and used for being connected with a drainage apparatus, and drainage is achieved through the main tube. The invention further provides a preparation method of the silver nano hydrogel coating, the balloon nasogastric tube with the silver nano hydrogel coating is provided, and the problems that in the prior art, after ESD treatment, esophageal stenosis occurs, and targeted expansion and focus treatment cannot be conducted are solved.

Description

Technical Field

[0001] The invention belongs to the technical field of gastric tubes, and specifically refers to a nasogastric tube with a silver nano-hydrogel coating balloon. Background Art

[0002] Endoscopic esophageal mucosal dissection (ESD) is a key method for treating early esophageal cancer. However, for patients with early esophageal cancer with more than three-quarters of the circumference, esophageal stenosis will almost always occur after ESD treatment. Esophageal stenosis can seriously affect the patient's quality of life, leading to difficulty swallowing and even inability to eat. At present, common methods for preventing esophageal stenosis after ESD surgery include mucosal injection of dexamethasone and autologous skin grafting. However, these methods have their limitations in clinical applications, and their actual application range is relatively limited. For example, there are certain contraindications for dexamethasone injection in cancer patients; autologous skin grafting is expensive and has a complicated production process. Summary of the invention

[0003] In view of the above situation, in order to overcome the defects of the prior art, the present invention provides a nasogastric tube using a silver nano-hydrogel coated balloon, which solves the problems of esophageal stenosis, inability to perform targeted esophageal dilation, and wound ulcer treatment after ESD treatment in the prior art.

[0004] The technical solution adopted by the present invention is as follows: The present invention provides a silver nano-hydrogel coated balloon nasogastric tube, comprising a main tube and a balloon fixedly arranged outside the main tube, the main tube is a hollow hose, the balloon is connected through an inflation tube, the inflation tube is provided with an inflation valve for inflating or deflating the balloon, the main tube is connected to a drainage head for connecting a drainage device, and drainage is achieved through the main tube.

[0005] Furthermore, a through channel is provided in the center of the balloon, the main pipe passes through the channel, the internal space of the balloon is not connected with the internal space of the main pipe, the inflation pipe penetrates into the main pipe, the end of the inflation pipe is a connecting section, the connecting section passes through the main pipe and is connected with the balloon.

[0006] When the balloon is inflated or deflated, the gas enters the balloon through the gaps between the inflation tubes, and the gas does not enter the main tube.

[0007] During drainage, the drainage fluid is discharged through the main tube and will not enter the inflation tube and balloon.

[0008] Furthermore, the bottom of the main pipe is provided with a plurality of side holes arranged in opposite directions to assist drainage.

[0009] Furthermore, the outer part of the balloon is provided with a nano-silver coating, which has antibacterial activity, low cytotoxicity, sustained antibacterial effect and the function of promoting mucosal repair, and can promote mucosal repair, and the mucosal repair is accelerated after use.

[0010] This solution also provides a method for preparing a silver nano-hydrogel coating, comprising the following steps:

[0011] S1. Preparation of nano silver ion solution

[0012] Mix and stir silver sulfate, deionized water and tetraethyl orthosilicate, disperse the mixture in water, and add polyvinyl alcohol and tannic acid to obtain a nano silver ion solution;

[0013] S2, adding zeolite molecular sieve to the nano silver ion solution, performing ion exchange, and obtaining a dispersion of zeolite molecular sieve rich in silver ions;

[0014] S3, adding high-valent cation solution to the dispersion, stirring evenly, and standing to form a gel;

[0015] S4. Coat the gel on the balloon surface.

[0016] The beneficial effects achieved by the present invention using the above structure are as follows: This solution provides a gastric tube with a balloon, the surface of which has an anti-inflammatory and repair-promoting coating material, which prevents excessive scar formation on the wound surface after surgery and causes stenosis of the lumen, while promoting early repair of the esophageal mucosa. The porous carrier carries nano silver ions, and the antibacterial and antiviral effects of silver ions are utilized. At the same time, it can have a slow release effect, and the use of hydrogel as a carrier facilitates uniform coating on the balloon, which can effectively resist common bacteria, promote mucosal repair, promote wound healing, and improve immunity. The overall solution solves the problems of esophageal stenosis after ESD treatment in the prior art, inability to expand in a targeted manner, and inability to treat lesions. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a schematic diagram of the overall structure of this scheme;

[0018] Figure 2 This is a balloon connection diagram in Example 1;

[0019] Figure 3 This is a balloon connection diagram of Example 2;

[0020] Figure 4 These are comparison pictures of wound surfaces examined by endoscopy during the trial.

[0021] Among them, 1. Main tube; 2. Balloon; 3. Inflation tube; 4. Inflation valve; 5. Drainage head; 6. Side hole

[0022] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention. DETAILED DESCRIPTION

[0023] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0024] In the description of the present invention, it should be understood that terms such as “upper”, “lower”, “front”, “back”, “left”, “right”, “top”, “bottom”, “inside” and “outside” indicating directions or positional relationships are based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore should not be understood as limiting the present invention.

[0025] like Figure 1 The present invention provides a silver nano-hydrogel coated balloon nasogastric tube, comprising a main tube 1 and a balloon 2 fixedly arranged outside the main tube 1, wherein the main tube 1 is a hollow hose, the balloon 2 is connected through an inflation tube 3, the inflation tube 3 is provided with an inflation valve 4 for inflating or deflating the balloon 2, the main tube 1 is connected to a drainage head 5 for connecting a drainage device to achieve drainage through the main tube 1.

[0026] The bottom of the main pipe 1 is provided with a plurality of side holes 6 facing each other to assist drainage.

[0027] The outer part of the balloon 2 is provided with a nano-silver coating, which has antibacterial activity, low cytotoxicity, sustained antibacterial effect and the function of promoting mucosal repair, and can promote mucosal repair. After use, mucosal repair is accelerated.

[0028] In one embodiment, the main tube 1 is 90-100 cm long, and the balloon 2 is 12 cm long. The main tube is long enough, and the balloon 2 can be moved up and down according to the location of the lesion. The balloon 2 is made of medical silicone and can be expanded to a diameter of 2-2.5 cm.

[0029] like Figure 2 In embodiment 1, a through channel is provided in the center of the balloon 2, the main pipe 1 passes through the channel, the internal space of the balloon 2 is not connected to the internal space of the main pipe 1, the inflation pipe 3 penetrates into the main pipe 1, the end of the inflation pipe 3 is a connecting section, the connecting section passes through the main pipe 1, and is connected to the balloon 2.

[0030] like Figure 3 In the second embodiment, a through channel is provided in the center of the balloon 2, the main pipe 1 passes through the channel, the internal space of the balloon 2 is not connected with the internal space of the main pipe 1, the inflation tube 3 is fixedly attached to the outside of the main pipe 1, and the inflation tube 3 is connected with the balloon 2.

[0031] When the balloon 2 is inflated or deflated, the gas enters the balloon 2 through the inflation tubes 3 and does not enter the main tube 1 .

[0032] During drainage, the drainage fluid is discharged through the main tube 1 and will not enter the inflation tube 3 and the balloon 2 .

[0033] A method for preparing a silver nano-hydrogel coating comprises the following steps:

[0034] S1. Preparation of nano silver ion solution

[0035] Mix and stir silver sulfate, deionized water and tetraethyl orthosilicate, disperse the mixture in water, and add polyvinyl alcohol and tannic acid to obtain a nano silver ion solution;

[0036] S2, adding zeolite molecular sieve to the nano silver ion solution, performing ion exchange, and obtaining a dispersion of zeolite molecular sieve rich in silver ions;

[0037] S3, adding high-valent cation solution to the dispersion, stirring evenly, and standing to form a gel;

[0038] S4. Coat the gel on the balloon surface.

[0039] The beneficial effects of the present invention are further illustrated by experiments below;

[0040] Included population: patients who underwent esophageal ESD for early esophageal cancer and those who underwent endoscopic esophageal resection ranging from 3 / 4 circumference to full circumference resection.

[0041] Excluded population: Patients who underwent ESD resection for early esophageal cancer but whose endoscopic resection range was less than 3 / 4 of the circumference.

[0042] The patients were randomly divided into three groups, and each group of patients wore the tube for 1 month after surgery.

[0043] Group A (control group): conventional non-balloon gastric tube was used (the data of this group were based on previous retrospective data);

[0044] Group B (experimental group 1): using an uncoated balloon gastric tube;

[0045] Group C (experimental group 2): a balloon gastric tube coated with nanosilver hydrogel was used.

[0046] Method of gastric tube placement:

[0047] Group A: The gastric tube was placed into the stomach using conventional methods;

[0048] Group B: According to the depth of lesion resection, the balloon gastric tube was placed at a specified depth, inflated to make the balloon close to the wound surface, and the degree of inflation was controlled within the patient's tolerance range;

[0049] Group C: The method was the same as that of group B, but a nanosilver hydrogel-coated balloon gastric tube was used.

[0050] Observation time point:

[0051] All patients were evaluated at the following time points: immediately after surgery, 1 month after surgery, and 6 months after surgery.

[0052] Research results, such as Figure 4 As shown:

[0053] 1. Stenosis assessment

[0054] Group A: (conventional gastric tube without balloon)

[0055] 6 months after surgery: All patients developed severe stenosis;

[0056] Endoscopic examination: Ordinary gastroscopes cannot pass through strictures;

[0057] Diet: Can only eat liquid food.

[0058] Group B: (uncoated balloon gastric tube)

[0059] 6 months after surgery: the degree of stenosis was significantly reduced compared with group A;

[0060] Endoscopic examination: some patients have resistance when ordinary gastroscope passes through, but ultra-thin gastroscope can pass through;

[0061] Dietary status: Can eat liquid or semi-liquid food; some patients have resistance when eating solid food (such as beef).

[0062] Group C: (Nanosilver hydrogel coated balloon gastric tube)

[0063] 6 months after surgery: the stenosis is the mildest;

[0064] Endoscopic examination: The ordinary gastroscope passed smoothly;

[0065] Dietary status: The patient can eat normally without obvious restrictions.

[0066] 2. Wound healing assessment

[0067] Group A:

[0068] One month after surgery: Endoscopic examination showed that the wound ulcer had not healed completely, and there were still ulcers and white tongue coating.

[0069] Group B:

[0070] One month after surgery: Endoscopic examination showed that the wound ulcer was basically healed, and the surrounding mucosa was congested and red.

[0071] Group C:

[0072] One month after surgery: Endoscopic examination showed that the wound had healed completely.

[0073] in conclusion

[0074] By using the gastric tube with a balloon in this solution in combination with the nano-silver ion coating, the problems of esophageal and wound ulcers can be significantly improved.

[0075] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0076] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0077] The present invention and its embodiments are described above, and such description is not restrictive. The drawings show only one embodiment of the present invention, and the actual structure is not limited thereto. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design a structure and embodiment similar to the technical solution without creativity, which should belong to the protection scope of the present invention.

Claims

1. A nasogastric tube with a silver nano-hydrogel coating balloon, characterized in that: It includes a main pipe and a balloon fixed outside the main pipe. The main pipe is a hollow hose. The balloon is connected to an inflation pipe. The inflation pipe is provided with an inflation valve for inflating or deflating the balloon. The main pipe is connected to a drainage head for connecting a drainage device for drainage.

2. A nasogastric tube with a silver nano-hydrogel coating balloon according to claim 1, characterized in that: A through channel is provided in the center of the balloon, the main pipe passes through the channel, the internal space of the balloon is not connected with the internal space of the main pipe, the inflation pipe penetrates into the main pipe, the end of the inflation pipe is a connecting section, the connecting section passes out of the main pipe and is connected with the balloon.

3. The silver nano-hydrogel coated balloon nasogastric tube according to claim 2, characterized in that: The outer part of the balloon is provided with a nano silver particle coating.

4. The silver nano-hydrogel coated balloon nasogastric tube according to claim 2, characterized in that: The bottom of the main pipe is provided with a plurality of side holes arranged opposite to each other.

5. A method for preparing a silver nano-hydrogel coating, characterized in that: The steps include: S1. Preparation of nano silver ion solution Mix and stir silver sulfate, deionized water and tetraethyl orthosilicate, disperse the mixture in water, and add polyvinyl alcohol and tannic acid to obtain a nano silver ion solution; S2, adding zeolite molecular sieve to the nano silver ion solution, performing ion exchange, and obtaining a dispersion of zeolite molecular sieve rich in silver ions; S3, adding high-valent cation solution to the dispersion, stirring evenly, and standing to form a gel; S4. Coat the gel on the balloon surface.

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