Preparation process of nano-silver antibacterial wound patch

Abstract

The invention relates to the technical field of wound patch preparation, in particular to a preparation process of a nano-silver antibacterial wound patch, which comprises the following steps: S1, preparing materials; s2, selecting a base material; s3, preparing a silver-plated crystal film by adopting a magnetron sputtering technology, and S4, uniformly coating the prepared pure nano-silver particles on an adhesive layer to form a basic shape of the nano-antibacterial silver adhesive bandage; and S5, cutting the compounded adhesive bandage into required shapes and sizes by using cutting equipment, packaging the cut adhesive bandage, and sterilizing the adhesive bandage. The nano-silver antibacterial wound patch has strong antibacterial performance: the particle size of nano-silver is extremely small and is generally 1-100 nanometers, the micro size enables the nano-silver to rapidly permeate into bacterial cells and effectively kill bacteria, and the nano-silver antibacterial wound patch not only has good stability, but also is not easy to oxidize, so that the nano-silver antibacterial wound patch has good antibacterial performance; the arranged nano-silver antibacterial wound patch can promote healing, and nano-silver can promote growth and repair of skin cells besides the antibacterial function.

Description

Technical Field

[0001] The invention relates to the technical field of wound patch preparation, and in particular to a preparation process of a nano-silver antibacterial wound patch. Background Art

[0002] Wound patches are one of the most commonly used medical products in daily life. They have the function of protecting wounds and avoiding secondary injuries caused by wound exposure. Existing wound patches have poor air permeability and unsatisfactory antibacterial and anti-inflammatory effects. If they are not replaced in time, they may cause wound infection and affect wound healing. At present, medical staff usually judge whether the wound patch needs to be replaced based on their own experience. For users without relevant experience, they either replace the wound patch regularly or judge whether the wound patch needs to be replaced by partially disassembling and observing the wound patch.

[0003] The current wound patch has a limited scope of use, does not have a strong antibacterial and anti-inflammatory effect, and cannot assist in promoting the growth and repair of skin cells. A preparation process for a nano-silver antibacterial wound patch is needed to solve this problem. Summary of the invention

[0004] The purpose of the present invention is to provide a preparation process of a nano silver antibacterial wound patch to solve the problems raised in the above background technology.

[0005] To achieve the above object, the present invention provides the following technical solution: a preparation process of a nano silver antibacterial wound patch, comprising the following steps:

[0006] S1. Preparation of materials, such as substrate, adhesive, water-absorbing layer, antibacterial layer, release paper and medical nanosilver particles;

[0007] S2, selection of substrate; bonding the substrate to the water-absorbing layer through an adhesive, adding drugs, coating the drugs made from the antibacterial layer evenly on the adhesive layer, and controlling the coating amount of the adhesive to ensure that the wound dressing has sufficient viscosity;

[0008] S3. Secondly, the silver-plated crystalline film is prepared by magnetron sputtering technology. First, oxygen and ammonia active gases are added to the sputtering discharge gas to deposit a compound film of the target material and gas molecules. By controlling the gas pressure and sputtering power in the vacuum chamber, a stable deposition rate can be obtained. By precisely controlling the sputtering coating time, a uniform and high-precision film thickness can be obtained. Silver metal is evaporated in a vacuum environment to deposit silver ions on the surface of the fabric with good repeatability. The sputtered particles are not affected by gravity, and the positions of the target and the substrate can be freely arranged. The adhesion strength between the substrate and the film is more than 10 times that of the general vapor-deposited film. Because the sputtered particles carry high energy, they will continue to diffuse on the film-forming surface to obtain a hard and dense film. At the same time, the high energy enables the substrate to obtain a silver-plated crystalline film at a lower temperature.

[0009] S4, compounding the obtained silver-plated crystal film with the release paper to form the basic shape of the nano antibacterial silver wound dressing;

[0010] S5. Use cutting equipment to cut the composite bandage into required shapes and sizes, control the cutting accuracy, ensure that the size of the bandage meets the requirements, package the cut bandage to protect it from contamination and damage, and sterilize the bandage;

[0011] S6. After the nano-silver antibacterial wound patch is prepared as a finished product, it is necessary to clean the wound before use. Use sterile saline or clean water to gently rinse the wound, ensure that the wound and surrounding skin are clean and dry, use a sterile cotton swab or gauze to dip in an appropriate amount of iodine or medical alcohol to disinfect the wound, and open the package of the nano-silver antibacterial dressing to check whether the dressing is intact and undamaged. Apply the dressing gently to the wound to ensure that the dressing fits tightly to the wound without bubbles or wrinkles. Use a sterile bandage or adhesive tape to fix the dressing to prevent the dressing from moving or falling off;

[0012] S7. Regular changes: Change the dressing every 24-48 hours according to the wound condition and doctor's advice. When changing the dressing, first gently peel off the old dressing and observe the wound condition. If there is exudation or bleeding in the wound, clean it in time and replace it with a new dressing.

[0013] As a preferred technical solution of the present invention, the substrate in step S2 is a non-woven fabric or a PE film, and the substrate has good air permeability, water absorption and softness.

[0014] As a preferred technical solution of the present invention, the solvent mentioned in step S3 is water or methanol.

[0015] As a preferred technical solution of the present invention, the Chinese medicine composition of the antibacterial layer in step S2 is Panax notoginseng, Salvia miltiorrhiza, Nepeta tenuifolia, Sargentophyllum sappan, Sappan wood and Celastrus orbiculatus. After the Chinese medicine is crushed by a grinder, an appropriate amount of ethanol is added and stirred evenly.

[0016] As a preferred technical solution of the present invention, the adhesive in step S2 is selected from an adhesive with good viscosity and biocompatibility, which is one of an acrylic adhesive and a silicone adhesive.

[0017] As a preferred technical solution of the present invention, the bandage may be sterilized by radiation sterilization or ethylene oxide sterilization in step S5.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] (1) The present invention is a process for preparing a nano-silver antibacterial wound patch. The nano-silver antibacterial wound patch provided by the present invention has strong antibacterial properties: the particle size of nano-silver is extremely small, usually between 1-100 nanometers. This tiny size enables it to quickly penetrate bacterial cells and destroy their structure, thereby effectively killing bacteria. It not only has good stability, but is also not easily oxidized.

[0020] (2) The present invention is a process for preparing a nano-silver antibacterial wound patch. The nano-silver antibacterial wound patch provided by the present invention can promote healing: in addition to antibacterial properties, nano-silver can also promote the growth and repair of skin cells. Studies have shown that nano-silver can promote the synthesis of collagen and accelerate wound healing. The nano-silver antibacterial dressing is made of soft and breathable materials, which can reduce friction and pain of the wound and improve the comfort of the patient. The nano-silver antibacterial wound patch mainly kills bacteria by contact. When bacteria come into contact with nano-silver particles, the nano-silver particles will combine with the bacterial cell membrane, interfere with the normal physiological function of the bacteria, and thus inhibit the growth and reproduction of the bacteria. DETAILED DESCRIPTION

[0021] The invention is further described below in conjunction with specific implementation methods:

[0022] Example 1

[0023] Embodiment 1, comprises the following steps:

[0024] S1. Preparation of materials, such as substrate, adhesive, water-absorbing layer, antibacterial layer, release paper and medical nanosilver particles;

[0025] S2, selection of substrate; bonding the substrate to the water-absorbing layer through an adhesive, adding drugs, coating the drugs prepared from the antibacterial layer evenly on the adhesive layer, and controlling the coating amount of the adhesive to ensure that the wound dressing has sufficient viscosity, the substrate is a non-woven fabric, a PE film, and the substrate has good air permeability, water absorption and softness;

[0026] S3. Secondly, the silver-plated crystalline film is prepared by magnetron sputtering technology. First, oxygen and ammonia active gases are added to the sputtering discharge gas to deposit a compound film of the target material and gas molecules. By controlling the gas pressure and sputtering power in the vacuum chamber, a stable deposition rate can be obtained. By precisely controlling the sputtering coating time, a uniform and high-precision film thickness can be obtained. Silver metal is evaporated in a vacuum environment to deposit silver ions on the surface of the fabric with good repeatability. The sputtered particles are not affected by gravity, and the positions of the target and the substrate can be freely arranged. The adhesion strength between the substrate and the film is more than 10 times that of the general vapor-deposited film. Because the sputtered particles carry high energy, they will continue to diffuse on the film-forming surface to obtain a hard and dense film. At the same time, the high energy enables the substrate to obtain a silver-plated crystalline film at a lower temperature.

[0027] Among them, magnetron sputtering belongs to the category of glow discharge, and uses the principle of cathode sputtering for film coating. The film particles come from the cathode sputtering effect of argon ions on the cathode target in the glow discharge. After the xenon ions sputter the target atoms, they are deposited on the surface of the component to form the required film layer. The magnetron principle is to use the special distribution of orthogonal electromagnetic fields to control the trajectory of electron motion in the electric field, so that the electrons become cycloid motion in the orthogonal electromagnetic field;

[0028] Among them, the nanosilver in the silver-plated crystal film has good stability and is not easily oxidized. Under certain conditions, it can slowly release silver ions and kill bacteria mainly by contact. When bacteria come into contact with nanosilver particles, the nanosilver particles will combine with the bacterial cell membrane, interfering with the normal physiological functions of the bacteria, thereby inhibiting the growth and reproduction of the bacteria.

[0029] S4, compounding the obtained silver-plated crystal film with the release paper to form the basic shape of the nano antibacterial silver wound dressing;

[0030] S5. Use cutting equipment to cut the composite bandage into required shapes and sizes, control the cutting accuracy, ensure that the size of the bandage meets the requirements, package the cut bandage to protect the bandage from contamination and damage, and sterilize the bandage. The bandage can be sterilized by radiation sterilization or ethylene oxide sterilization;

[0031] In this embodiment, the Chinese medicine composition of the antibacterial layer in step S2 is Panax notoginseng, Salvia miltiorrhiza, Nepeta tenuifolia, Sargentodoxae, Sappan wood and Celastrus orbiculatus. The Chinese medicine is crushed by a grinder and then added with an appropriate amount of ethanol and stirred evenly. The adhesive in step S2 is selected to have good viscosity and biocompatibility, which is one of acrylic adhesive and silicone adhesive.

[0032] Example 2

[0033] Example 2, this embodiment further illustrates Example 1, including the following steps: S6, after the nano-silver antibacterial wound patch is prepared as a finished product, it is necessary to clean the wound before use, use sterile saline or water to gently rinse the wound, ensure that the wound and surrounding skin are clean and dry, use a sterile cotton swab or gauze to dip in an appropriate amount of iodine or medical alcohol, disinfect the wound, and open the package of the nano-silver antibacterial dressing to check whether the dressing is intact and undamaged. Apply the dressing gently to the wound to ensure that the dressing fits tightly to the wound without bubbles or wrinkles. Use a sterile bandage or tape to fix the dressing to prevent the dressing from moving or falling off;

[0034] S7. Regular changes: Change the dressing every 24-48 hours according to the wound condition and doctor's advice. When changing the dressing, first gently peel off the old dressing and observe the wound condition. If the wound has exudate or bleeding, clean it in time and replace it with a new dressing.

Claims

1. A preparation process of a nano silver antibacterial wound patch, characterized in that: The following steps are involved: S1. Preparation of materials, such as substrate, adhesive, water-absorbing layer, antibacterial layer, release paper and medical nanosilver particles; S2, selection of substrate; bonding the substrate to the water-absorbing layer through an adhesive, adding drugs, coating the drugs made from the antibacterial layer evenly on the adhesive layer, and controlling the coating amount of the adhesive to ensure that the wound dressing has sufficient viscosity; S3. Secondly, the silver-plated crystalline film is prepared by magnetron sputtering technology. First, oxygen and ammonia active gases are added to the sputtering discharge gas to deposit a compound film of the target material and gas molecules. By controlling the gas pressure and sputtering power in the vacuum chamber, a stable deposition rate can be obtained. By precisely controlling the sputtering coating time, a uniform and high-precision film thickness can be obtained. Silver metal is evaporated in a vacuum environment to deposit silver ions on the surface of the fabric with good repeatability. The sputtered particles are not affected by gravity, and the positions of the target and the substrate can be freely arranged. The adhesion strength between the substrate and the film is more than 10 times that of the general vapor-deposited film. Because the sputtered particles carry high energy, they will continue to diffuse on the film-forming surface to obtain a hard and dense film. At the same time, the high energy enables the substrate to obtain a silver-plated crystalline film at a lower temperature. S4, compounding the obtained silver-plated crystal film with the release paper to form the basic shape of the nano antibacterial silver wound dressing; S5. Use cutting equipment to cut the composite bandage into required shapes and sizes, control the cutting accuracy, ensure that the size of the bandage meets the requirements, package the cut bandage to protect it from contamination and damage, and sterilize the bandage; S6. After the nano-silver antibacterial wound patch is prepared as a finished product, it is necessary to clean the wound before use. Use sterile saline or clean water to gently rinse the wound, ensure that the wound and surrounding skin are clean and dry, use a sterile cotton swab or gauze to dip in an appropriate amount of iodine or medical alcohol to disinfect the wound, and open the package of the nano-silver antibacterial dressing to check whether the dressing is intact and undamaged. Apply the dressing gently to the wound to ensure that the dressing fits tightly to the wound without bubbles or wrinkles. Use a sterile bandage or adhesive tape to fix the dressing to prevent the dressing from moving or falling off; S7. Regular changes: Change the dressing every 24-48 hours according to the wound condition and doctor's advice. When changing the dressing, gently peel off the old dressing and observe the wound condition. If the wound is exuding or bleeding, it should be cleaned and replaced with a new dressing in time.

2. The preparation process of the nano silver antibacterial wound patch according to claim 1, characterized in that: In the step S2, the substrate is a non-woven fabric or a PE film, and the substrate has good air permeability, water absorption and softness.

3. The preparation process of the nano silver antibacterial wound patch according to claim 1, characterized in that: In step S3, the solvent is water or methanol.

4. The preparation process of the nano silver antibacterial wound patch according to claim 1, characterized in that: The Chinese medicine composition of the antibacterial layer in step S2 is Panax notoginseng, Salvia miltiorrhiza, Nepeta tenuifolia, Sargentophyllum sappan, Sappan wood and Celastrus orbiculatus. The Chinese medicine is crushed by a crusher and then added with a proper amount of ethanol and stirred evenly.

5. The preparation process of the nano silver antibacterial wound patch according to claim 1, characterized in that: The adhesive in step S2 is selected from an adhesive with good viscosity and biocompatibility, such as an acrylic adhesive and a silicone adhesive.

6. The preparation process of the nano silver antibacterial wound patch according to claim 1, characterized in that: In step S5, the wound dressing may be sterilized by radiation sterilization or ethylene oxide sterilization.