Synthetic method of amlodipine impurity
Through a new synthesis method of amlodipine impurities, using the reaction of alkali liquid and acid liquid and the esterification reaction of active ester catalyst, the problems of difficult preparation process, high cost and low product purity in the existing method are solved. High purity and high efficiency of impurity synthesis.
CN119350228APending Publication Date: 2025-01-24GUANGDONG JUNHUANUO PHARMACEUTICAL CO LTD
Patent Information
- Application Number
- CN202411617819.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-13
- Publication Date
- 2025-01-24
AI Technical Summary
Technical Problem
The existing amlodipine impurity synthesis method has the problem that the preparation process is difficult, costly, and the product is low and unstable.
Method used
A new synthetic method, including the reaction of ammliden and alkaline liquid, then adds acid liquid to hydrolysis, then extraction and concentration, and finally the esterization response was performed through the active ester catalyst to obtain the target impurities.
Benefits of technology
This method is simple to operate, has mild reaction conditions, simple post-processing, does not involve complex separation processes, has high product purity, and can quickly and accurately separate the target product.
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Figure CN119350228A_ABST
Abstract
The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method and application of amlodipine impurities. The method comprises the following steps: 1) weighing raw materials and a solvent, uniformly mixing, heating the system to reflux, dropwise adding alkali liquor, uniformly mixing, reacting, adding acid liquor after the reaction is completed, adding an organic solvent for extraction after spin-drying, combining organic phases, concentrating, and carrying out vacuum pump pull-drying treatment to obtain an impurity L; and 2) adding a solvent into the impurity L, uniformly mixing, adding an active ester catalyst, reacting, drying by a vacuum pump, washing the product, drying the organic phase, and spin-drying to obtain the target impurity. The synthesis method provided by the invention is simpler to operate, avoids a long path of amlodipine impurity synthesis, is milder in reaction condition, is simpler in post-treatment, does not involve a complicated separation process, and is high in product purity.
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Citation Information
Cited By
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