Composite probiotic solid beverage with high adsorbability to helicobacter pylori

Abstract

The invention relates to the field of compound probiotic beverages, in particular to a compound probiotic solid beverage with high adsorbability to helicobacter pylori. The invention relates to a composite probiotic solid beverage with high adsorbability to helicobacter pylori. The composite probiotic solid beverage is prepared from the following components in parts by weight: 75-120 parts of a functional sweetening agent, 0.1-1 part of passion fruit powder, 0.5-2 parts of cabbage powder, 0.1-1 part of herba portulacae powder, 0.01-0.1 part of inactivated lactobacillus reuteri, 0.1-1 part of inactivated lactobacillus plantarum and 0-1 part of a nutritional supplement. The composite probiotic solid beverage provided by the invention has good inhibition, adsorption and removal effects on helicobacter pylori.

Description

Technical Field

[0001] The present application relates to the field of composite probiotic beverages, and more specifically, to a composite probiotic solid beverage having high adsorption capacity for Helicobacter pylori. Background Art

[0002] In the medical field, gastric diseases caused by Helicobacter pylori infection have always attracted much attention. At present, the treatment options for Helicobacter pylori infection mainly include two categories: drug therapy and dietary conditioning. Drug treatment usually relies on combined antibiotic therapy, such as amoxicillin, clarithromycin, etc. These drugs relieve symptoms and cure the disease by directly killing the bacteria. However, long-term use of antibiotics may cause bacteria to develop drug resistance, making subsequent treatment more difficult and may even cause secondary infection. In addition, the side effects of antibiotics cannot be ignored, such as imbalance of intestinal flora, decreased immunity, etc., which may have an adverse effect on the patient's overall health.

[0003] In terms of dietary conditioning, although patients are advised to eat more fiber-rich foods, such as vegetables and fruits, and eat less spicy foods, these measures can help alleviate symptoms, but they cannot fundamentally solve the problem. This is because Helicobacter pylori hidden deep in the gastric mucosa is difficult to completely eliminate through dietary conditioning, and the effect of dietary conditioning varies from person to person, lacking stability and reliability.

[0004] However, long-term reliance on antibiotics for treatment may not only increase the risk of secondary infection in patients, but also promote the rise of bacterial resistance. On the other hand, although non-invasive auxiliary treatments, such as changing eating habits and consuming specific foods, can alleviate symptoms to a certain extent, the effect is not obvious and unstable. Summary of the invention

[0005] In order to solve the above problems, the present application provides a composite probiotic solid beverage with high adsorption to Helicobacter pylori, which has a good adsorption and removal effect on Helicobacter pylori.

[0006] In a first aspect, the present application provides a composite probiotic solid beverage with high adsorption to Helicobacter pylori, using the following technical solution: A composite probiotic solid beverage with high adsorption to Helicobacter pylori comprises the following components: 75-120 parts of functional sweetener, 0.1-1 parts of passion fruit powder, 0.5-2 parts of cabbage powder, 0.1-1 parts of purslane powder, 0.01-0.1 parts of inactivated Lactobacillus reuteri, 0.1-1 parts of inactivated Lactobacillus plantarum and 0-1 parts of nutritional supplement.

[0007] By adopting the above technical scheme, inactivated Lactobacillus reuteri, inactivated Lactobacillus plantarum, passion fruit powder, cabbage powder and purslane powder are integrated into the compound probiotic solid beverage. Through a complex synergistic mechanism, they act together on Helicobacter pylori, showing good adsorption and inhibition effects.

[0008] Specifically, inactivated Lactobacillus reuteri and inactivated Lactobacillus plantarum can competitively occupy the intestinal surface with their high adhesion to intestinal cells, effectively blocking the adhesion and colonization of Helicobacter pylori, and also have high adsorption to Helicobacter pylori, and excrete Helicobacter pylori after adsorbing it, playing a role in improving gastritis and gastric ulcers. At the same time, the metabolites they produce, such as polypeptide antibacterial active substances, directly have an antibacterial or bactericidal effect on Helicobacter pylori.

[0009] Passion fruit powder is not only rich in vitamins, minerals and dietary fiber, which helps to optimize the intestinal microenvironment and promote the growth and proliferation of probiotics, but also indirectly enhances the inhibitory effect of probiotics on Helicobacter pylori. The antibacterial ingredients such as glucosinolates in cabbage powder, together with the ω-3 fatty acids, vitamin C and antioxidants in purslane powder, not only directly inhibit the growth of Helicobacter pylori, but also reduce the inflammatory response caused by it through anti-inflammatory effects, protecting the gastric mucosa from further damage. These ingredients work synergistically, not only strengthening the intestinal barrier function, but also improving the body's overall disease resistance by regulating the immune system, and jointly constructing an intestinal environment that is unfavorable to Helicobacter pylori, thus playing an excellent health-promoting role in compound probiotic solid beverages.

[0010] Preferably, the passion fruit powder is 0.3-0.5 parts, the cabbage powder is 1.2-1.6 parts, and the purslane powder is 0.5-1 parts.

[0011] By adopting the above technical scheme, the dosage coordination relationship of passion fruit powder, cabbage powder and purslane powder in the composite probiotic solid beverage is further limited.

[0012] In compound probiotic solid beverages, the dosage of passion fruit powder, cabbage powder and purslane powder is crucial. Adding passion fruit powder in an appropriate amount can utilize its rich vitamin C and prebiotic properties to enhance the body's immunity, while promoting the growth of probiotics and indirectly enhancing the inhibitory effect on Helicobacter pylori. The glucosinolate component in cabbage powder needs to reach a certain concentration to effectively bind to the surface protein of Helicobacter pylori to exert the best antibacterial effect. Purslane powder uses its polysaccharides and flavonoids as the main active ingredients. Adding an appropriate amount can synergize with probiotics and jointly inhibit the growth of Helicobacter pylori. The reasonable ratio of the three can not only enhance the effect of adsorbing Helicobacter pylori, but also assist in enhancing the antibacterial effect of inactivated Lactobacillus reuteri and inactivated Lactobacillus plantarum, and jointly maintain intestinal health.

[0013] Preferably, the inactivated Lactobacillus reuteri is 0.05-0.1 parts, and the inactivated Lactobacillus plantarum is 0.1-0.3 parts.

[0014] By adopting the above technical solution, the dosage relationship of inactivated Lactobacillus reuteri and inactivated Lactobacillus plantarum in the composite probiotic solid beverage is further limited, and the two inactivated probiotics play a synergistic role in the intestine to jointly maintain the balance of intestinal microecology. An appropriate amount of inactivated Lactobacillus reuteri can efficiently occupy the intestinal surface, form a competitive relationship with Helicobacter pylori, and effectively reduce its chances of attachment and growth. Inactivated Lactobacillus plantarum directly inhibits Helicobacter pylori by producing antibacterial substances.

[0015] When the dosage of inactivated Lactobacillus reuteri and inactivated Lactobacillus plantarum in the composite probiotic solid beverage reaches the optimal combination, the adsorption and inhibition of Helicobacter pylori can be significantly enhanced. This combination not only improves the antibacterial effect of probiotics, but also ensures the stability and health of the intestinal environment.

[0016] Preferably, the functional sweetener comprises a mixture of one or more of fructooligosaccharide powder, xylooligosaccharide powder, galacto-oligosaccharide powder and lactitol powder.

[0017] Preferably, the functional sweeteners are fructooligosaccharide powder, xylooligosaccharide powder, galacto-oligosaccharide powder and lactitol powder, wherein the fructooligosaccharide powder is 75-90 parts, the xylooligosaccharide powder is 5-10 parts, the galacto-oligosaccharide powder is 0.5-2 parts and the lactitol powder is 3-6 parts.

[0018] Although functional sweeteners do not directly adsorb Helicobacter pylori, they indirectly exert an inhibitory effect by regulating the intestinal microecology. By adopting the above technical solution, the selection and dosage of functional sweeteners are further limited. As prebiotics, these sweeteners can effectively promote the proliferation of beneficial bacteria such as bifidobacteria in the intestine, form a competitive relationship with Helicobacter pylori, and reduce its living space. At the same time, antibacterial substances such as short-chain fatty acids produced by the metabolism of beneficial bacteria and the acidic intestinal environment created are not conducive to the growth of Helicobacter pylori. In addition, they can also stimulate intestinal immune cells, enhance intestinal barrier function, improve the body's overall immunity, and further reduce the risk of Helicobacter pylori infection.

[0019] Preferably, the composite probiotic solid beverage further comprises curcumin and ginger powder.

[0020] Preferably, the curcumin is 0.001-0.01 parts, and the ginger powder is 0.5-2 parts.

[0021] Curcumin, a natural compound in the rhizomes of ginger plants, has multiple biological activities such as antioxidant, anti-inflammatory and antibacterial. Studies have shown that curcumin can destroy the cell wall of Helicobacter pylori, thereby inhibiting its growth and reproduction. This antibacterial effect helps reduce the number of Helicobacter pylori in the stomach, thereby alleviating gastric inflammation and discomfort caused by it.

[0022] Ginger powder contains spicy ingredients such as gingerol and volatile oil. These substances can stimulate the gastric mucosa and produce a large amount of gastric acid, thereby indirectly killing Helicobacter pylori.

[0023] By adopting the above technical solution, curcumin and ginger powder are added to the compound probiotic solid beverage, which can indirectly enhance the inhibitory effect on Helicobacter pylori through its antibacterial and anti-inflammatory effects. In addition, it also has the effect of adjusting the taste of the compound probiotic solid beverage, making the compound probiotic solid beverage more flavorful.

[0024] In a second aspect, the present application provides a method for preparing a composite probiotic solid beverage with high adsorption to Helicobacter pylori, using the following technical solution: A method for preparing a composite probiotic solid beverage with high adsorption to Helicobacter pylori comprises the following steps: Step 1: stirring and mixing passion fruit powder, cabbage powder, purslane powder and water, and then subjecting to microwave treatment at 300-400W for 20-30min to obtain a treated product; Step 2: mixing the inactivated Lactobacillus reuteri, the inactivated Lactobacillus plantarum and the treated material until uniform, and spray drying to obtain a mixture; Step 3: Mix the mixture with the remaining raw materials to obtain a composite probiotic solid beverage.

[0025] By adopting the above technical scheme, passion fruit powder, cabbage powder and purslane powder are treated under microwave conditions, and passion fruit powder, cabbage powder and purslane powder are rich in nutrients such as vitamins, minerals, dietary fiber and antioxidants. Specific microwave treatment can destroy cell walls, making these nutrients easier to extract and dissolve, thereby improving the nutritional value and bioavailability of the product. It can also promote the interaction between these ingredients and inactivated probiotics to form a more stable complex, thereby enhancing the adsorption and inhibition of Helicobacter pylori.

[0026] In summary, this application has the following beneficial effects: 1. Synergistic inhibition of Helicobacter pylori: Inactivated Lactobacillus reuteri, inactivated Lactobacillus plantarum, passion fruit powder, cabbage powder and purslane powder act together on Helicobacter pylori through a complex synergistic mechanism, and have a significant adsorption and inhibition effect on it. With its high intestinal cell adhesion, inactivated probiotics can effectively block the adhesion and colonization of Helicobacter pylori. At the same time, the produced polypeptide antibacterial active substances directly have an antibacterial or bactericidal effect on Helicobacter pylori. The antibacterial components in passion fruit powder, cabbage powder and purslane powder directly inhibit the growth of Helicobacter pylori, reduce the inflammatory response caused by it, and protect the gastric mucosa. This synergistic effect not only strengthens the intestinal barrier function, but also enhances the body's overall disease resistance.

[0027] 2. Optimize the intestinal microenvironment and enhance immunity: Passion fruit powder is rich in vitamins, minerals and dietary fiber, which helps to optimize the intestinal microenvironment, promote the growth and proliferation of probiotics, and indirectly enhance the inhibitory effect of probiotics on Helicobacter pylori. At the same time, functional sweeteners, as prebiotics, can effectively promote the proliferation of beneficial bacteria such as bifidobacteria in the intestine, form a competitive relationship with Helicobacter pylori, and reduce its living space. Antibacterial substances such as short-chain fatty acids produced by the metabolism of beneficial bacteria and the acidic intestinal environment created are not conducive to the growth of Helicobacter pylori. In addition, these ingredients can also stimulate intestinal immune cells, enhance intestinal barrier function, improve the body's overall immunity, and further reduce the risk of Helicobacter pylori infection.

[0028] 3. Improve nutritional value and bioavailability: By treating passion fruit powder, cabbage powder and purslane powder under microwave conditions, their cell walls can be destroyed, making it easier to extract and dissolve the nutrients such as vitamins, minerals, dietary fiber and antioxidants in these raw materials, thereby improving the nutritional value and bioavailability of the products. It can also promote the interaction between these ingredients and inactivated probiotics to form a more stable complex, further enhancing the adsorption and inhibition of Helicobacter pylori. DETAILED DESCRIPTION

[0029] The present application is further described in detail below with reference to the embodiments.

[0030] The raw materials used in the following examples and comparative examples are all commercially available products. Example

[0031] Example 1 A composite probiotic solid beverage with high adsorption to Helicobacter pylori comprises the following components: functional sweetener, passion fruit powder, cabbage powder, purslane powder, inactivated Lactobacillus reuteri, inactivated Lactobacillus plantarum, nutritional supplements, curcumin and ginger powder.

[0032] Functional sweeteners include fructooligosaccharide powder, xylooligosaccharide powder, galacto-oligosaccharide powder and lactitol powder.

[0033] The nutritional supplement is fish collagen peptides.

[0034] The specific content of each component is shown in Table 1.

[0035] Fructo-oligosaccharide powder was commercially available from Shandong Xingguang Shouchuang Biotechnology Co., Ltd.

[0036] Xylooligosaccharide powder was commercially available from Henan Yuanlong Biotechnology Co., Ltd.

[0037] Galacto-oligosaccharide powder was commercially available from Shandong Baolingbao Biological Co., Ltd.

[0038] Lactitol powder was commercially available from Shandong Lujian Biotechnology Co., Ltd.

[0039] Fish collagen peptides were commercially available from Hubei Ruibang Biotechnology Co., Ltd.

[0040] The inactivated Lactobacillus reuteri was purchased from Qingdao Miaopinyuan International Trade Co., Ltd.

[0041] The inactivated Lactobacillus plantarum was purchased from Shanenkang Biotechnology (Suzhou) Co., Ltd.

[0042] The present application also provides a method for preparing a composite probiotic solid beverage with high adsorption to Helicobacter pylori, comprising the following steps: Step 1: The total mass of passion fruit powder, cabbage powder, purslane powder and water is 1:1. Mix passion fruit powder, cabbage powder, purslane powder and water and stir until uniform.

[0043] The mixture was then treated with microwaves at 350 W for 25 min to obtain a treated product.

[0044] Step 2: Mix the inactivated Lactobacillus reuteri and the inactivated Lactobacillus plantarum with the treated material and stir until uniform.

[0045] It is then spray dried to obtain a mixture.

[0046] Step 3: Mix the mixture with the remaining raw materials and stir until uniform to obtain a composite probiotic solid beverage.

[0047] Mix the above-mentioned compound probiotic solid beverage with water to 1L and then drink it.

[0048] Example 2 A composite probiotic solid beverage with high adsorption to Helicobacter pylori, which is different from Example 1 in that the content of each component is different, as shown in Table 1 for details.

[0049] A method for preparing a composite probiotic solid beverage with high adsorption to Helicobacter pylori is different from that in Example 1 in that step 1 is subjected to microwave treatment at 300 W for 30 min.

[0050] Example 3 A composite probiotic solid beverage with high adsorption to Helicobacter pylori, which is different from Example 1 in that the content of each component is different, as shown in Table 1 for details.

[0051] A method for preparing a composite probiotic solid beverage with high adsorption to Helicobacter pylori is different from that in Example 1 in that step 1 is subjected to microwave treatment at 400 W for 20 min.

[0052] Example 4 A composite probiotic solid beverage with high adsorption to Helicobacter pylori, which is different from Example 1 in that the content of each component is different, as shown in Table 1 for details.

[0053] Example 5 A composite probiotic solid beverage with high adsorption to Helicobacter pylori, which is different from Example 1 in that curcumin and ginger powder are omitted.

[0054] Table 1 Comparative Example Comparative Example 1 A composite probiotic solid beverage with high adsorption to Helicobacter pylori, which is different from Example 1 in that passion fruit powder is replaced by dandelion powder.

[0055] Comparative Example 2 A composite probiotic solid beverage with high adsorption to Helicobacter pylori, which is different from Example 1 in that cabbage powder is replaced by broccoli powder.

[0056] Comparative Example 3 A composite probiotic solid beverage with high adsorption to Helicobacter pylori, which is different from Example 1 in that purslane powder is replaced by onion powder.

[0057] Comparative Example 4 A composite probiotic solid beverage with high adsorption to Helicobacter pylori, which is different from Example 1 in that passion fruit powder, cabbage powder and purslane powder are replaced by dandelion powder.

[0058] Comparative Example 5 A composite probiotic solid beverage with high adsorption to Helicobacter pylori, which is different from Example 1 in that passion fruit powder, cabbage powder and purslane powder are omitted.

[0059] Comparative Example 6 A composite probiotic solid beverage with high adsorption to Helicobacter pylori, which is different from Example 1 in that the inactivated Lactobacillus reuteri is replaced by inactivated Lactobacillus plantarum.

[0060] Comparative Example 7 A composite probiotic solid beverage with high adsorption to Helicobacter pylori, which is different from Example 1 in that the inactivated Lactobacillus plantarum is replaced by inactivated Lactobacillus reuteri.

[0061] Comparative Example 8 A method for preparing a composite probiotic solid beverage with high adsorption to Helicobacter pylori, which is different from that of Example 1 in that it comprises the following steps: mixing all raw materials to obtain a composite probiotic solid beverage.

[0062] Performance testing 1. Inhibitory effect on Helicobacter pylori Test sample: The composite probiotic solid beverage of Examples 1-5 and Comparative Examples 1-8 was blended with water to 1 L to obtain a sample to be tested.

[0063] Columbia medium (Oxiod, UK) was poured into plates, 15 mL per plate, and the plates were standard 9 mm plates. Helicobacter pylori ATCC 43504 (purchased from Shanghai Beino Biotechnology Co., Ltd.) was spread onto the plates (concentration was 1×10 8 CFU / plate), put them in Oxford cups, and add 100 μL of the sample to be tested into the Oxford cups respectively. After fixing for 1.5 h under microaerobic conditions, put them in a three-gas incubator and culture them for 60 h. The size of the inhibition ring was measured and repeated 3 times.

[0064] The average diameter of the inhibition zone is recorded in Table 2.

[0065] 2. Mouse treatment experiment: Test sample: The composite probiotic solid beverage of Example 1 and Comparative Examples 1-8 was blended with water to 1 L to obtain a sample to be tested.

[0066] Mice were given mixed antibiotic solution (ampicillin 10 mg / mL, gentamicin 1.2 mg / mL, azithromycin 10 mg / mL) by gavage, 0.3 mL / mouse, once a day, for 3 days. After gavage of mixed antibiotics for 7 days, mice were given 0.3 mL of freshly cultured Helicobacter pylori (1×10 9 CFU / mL), once every other day, for a total of 5 times.

[0067] The mice were fasted for 24 hours before gavage and for 2 hours after gavage. Two weeks after the last gavage, two mice were randomly selected and killed, and the gastric antrum tissue was taken, and RUT reagent was added. The cells were left to stand at room temperature. If the reagent turned red within 12 hours, it was positive, otherwise it was negative. At the same time, the gastric antrum-gastric body tissue was taken, fixed with 4% paraformaldehyde, embedded, sliced, and HE stained to determine whether the infection was positive. The positive results of RUT and HE staining indicated that the model was successfully established.

[0068] The mice with successful modeling were randomly divided into 10 groups, namely the model group, the example 1 group, and the comparative examples 1-8 groups, with 10 mice in each group. The mice without modeling were the blank control group (10 mice). The administration methods of each group were as follows: Blank control group: no intervention measures were taken.

[0069] Model group: intragastric administration of normal saline, 100 mg / (kg·d), for 4 consecutive weeks.

[0070] Group 1 of Example 1: The test sample of Example 1 was intragastrically administered at 100 mg / (kg·d) for 4 consecutive weeks.

[0071] Comparative Example 1-8 Group: Gavage the corresponding composite probiotic solid beverage of Comparative Example 1-8, 100 mg / (kg·d), for 4 consecutive weeks.

[0072] After 4 weeks of administration as described above, the mice were killed, and the gastric antrum tissue was taken and stained with RUT reagent. The mixture was allowed to stand at room temperature. If the reagent turned red within 12 hours, it was positive. Otherwise, it was negative. A negative result means that Helicobacter pylori was completely eradicated.

[0073] The test results are shown in Table 2 below.

[0074] Table 2 In the detection of the inhibitory effect on Helicobacter pylori, Example 1-5 has a larger average diameter of the antibacterial ring than Comparative Example 1-8, indicating that Example 1-5 has a better antibacterial effect than Comparative Example 1-8.

[0075] Specifically, in Comparative Examples 1-3, passion fruit powder, cabbage powder, and purslane powder are replaced with other plant powders on the basis of Example 1; Comparative Example 4 is based on Example 1, only dandelion powder is used; and Comparative Example 5 is based on Example 1, passion fruit powder, cabbage powder, and purslane powder are omitted. The average diameter of the antibacterial ring of Comparative Examples 1-5 is significantly reduced compared with Example 1.

[0076] Comparative Examples 6 and 7 are based on Example 1, and contain only inactivated Lactobacillus plantarum and only inactivated Lactobacillus reuteri, respectively. According to the test data in Table 2, the average diameter of the antibacterial ring of Comparative Example 6 is significantly smaller than that of Example 1. Although the average diameter of the antibacterial ring of Comparative Example 7 is 18.25 mm, it is still not as large as the average diameter of Example 1.

[0077] This shows that the destruction of the combination of passion fruit powder, cabbage powder, and purslane powder, or the destruction of the combination of inactivated Lactobacillus reuteri and inactivated Lactobacillus plantarum, makes it impossible to fully exert the synergistic cooperation in the system.

[0078] Comparative Example 8 is based on Example 1, and the preparation method of the composite probiotic solid beverage is changed. Combined with the test data in Table 2, it can be seen that the ordinary blending method cannot give full play to the synergistic advantages of passion fruit powder, cabbage powder, purslane powder, inactivated Lactobacillus reuteri, and inactivated Lactobacillus plantarum.

[0079] In the mouse treatment experiment, the test sample of Example 1 showed a good effect of eradicating Helicobacter pylori. Although Comparative Examples 1-8 also had a certain effect of eradicating Helicobacter pylori, it was far less than that of Example 1.

[0080] In summary, the composite probiotic solid beverage provided in the present application has a good inhibitory and removal effect on Helicobacter pylori.

[0081] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A composite probiotic solid beverage with high adsorption to Helicobacter pylori, characterized in that: According to the mass percentage, it includes the following components: 75-120 parts of functional sweeteners, 0.1-1 parts of passion fruit powder, 0.5-2 parts of cabbage powder, 0.1-1 parts of purslane powder, 0.01-0.1 parts of inactivated Lactobacillus reuteri, 0.1-1 parts of inactivated Lactobacillus plantarum, and 0-1 parts of nutritional supplements.

2. The composite probiotic solid beverage with high adsorption to Helicobacter pylori according to claim 1, characterized in that: The passion fruit powder is 0.3-0.5 parts, the cabbage powder is 1.2-1.6 parts, and the purslane powder is 0.5-1 parts.

3. The composite probiotic solid beverage with high adsorption to Helicobacter pylori according to claim 1, characterized in that: The inactivated Lactobacillus reuteri is 0.05-0.1 part, and the inactivated Lactobacillus plantarum is 0.1-0.3 part.

4. The composite probiotic solid beverage with high adsorption to Helicobacter pylori according to claim 1, characterized in that: The functional sweetener comprises a mixture of one or more of fructooligosaccharide powder, xylooligosaccharide powder, galacto-oligosaccharide powder and lactitol powder.

5. The composite probiotic solid beverage with high adsorption to Helicobacter pylori according to claim 4, characterized in that: The functional sweeteners are oligofructose powder, oligoxylose powder, oligogalactose powder and lactitol powder, wherein the oligofructose powder is 75-90 parts, the oligoxylose powder is 5-10 parts, the oligogalactose powder is 0.5-2 parts and the lactitol powder is 3-6 parts.

6. The composite probiotic solid beverage with high adsorption to Helicobacter pylori according to claim 1, characterized in that: The composite probiotic solid beverage also contains curcumin and ginger powder.

7. The composite probiotic solid beverage with high adsorption to Helicobacter pylori according to claim 6, characterized in that: The curcumin is 0.001-0.01 parts, and the ginger powder is 0.5-2 parts.

8. A method for preparing a composite probiotic solid beverage having high adsorption to Helicobacter pylori according to any one of claims 1 to 7, characterized in that: The following steps are involved: Step 1: Passion fruit powder, cabbage powder, purslane powder and water are stirred and mixed, and then microwaved at 300-400 W for 20-30 min to obtain a treated product; Step 2: mixing the inactivated Lactobacillus reuteri, the inactivated Lactobacillus plantarum and the treated material until uniform, and spray drying to obtain a mixture; Step 3: Mix the mixture with the remaining raw materials to obtain a composite probiotic solid beverage.

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