Compact imaging device and method for clinical near-infrared two-region accurate imaging

Abstract

The invention provides a compact imaging device and method for clinical near-infrared two-region accurate imaging. The compact imaging device comprises an exciting light source module used for emitting exciting light with a specific wavelength to an imaging region; the circumference of the filtering wheel is at least provided with a first optical filter of a near-infrared first-zone spectrum band and a second optical filter of a near-infrared second-zone spectrum band, and the first driving device is used for sequentially driving the filtering wheel to be switched to the first optical filter and the second optical filter for filtering; the focusing assembly is used for focusing the camera; the camera is used for collecting and processing fluorescence imaging and outputting image data to the image processing module, and the image processing module is used for conducting image processing on the image data and outputting the image data to the display device for real-time image display. According to the invention, all imaging parts are designed in an integrated and miniaturized manner, and the focus is accurately positioned by switching the near-infrared two-region spectral band optical filter, so that the effects of compact structure, rapid and accurate positioning of the focus position and accurate imaging are achieved.

Description

Technical Field

[0001] The present invention relates to the field of fluorescence imaging technology, and in particular to a compact imaging device and method for clinical near-infrared zone II precision imaging. Background Art

[0002] With the development of modern medicine, near-infrared fluorescence imaging has been widely used in clinical diagnosis, among which near-infrared region I (NIR-I, 700-900nm) and near-infrared region II (NIR-II, 1000-1700nm) are two commonly used spectral regions. The development of infrared region I fluorescence imaging technology has been relatively mature and is widely used in medical diagnosis and clinical research, such as vascular imaging, lymph node identification, etc. However, due to the low detection depth, large light scattering effect, large tissue autofluorescence and background interference of near-infrared region I fluorescence, it is difficult to accurately calibrate the lesion part in clinical surgery, which seriously affects the surgical operation. For example: due to the scattering of light in the near-infrared region I and the influence of tissue autofluorescence, the lesion in the epidermis becomes larger. In clinical surgery, too much healthy tissue around the lesion will be removed, causing unnecessary physical damage to the patient. Compared with traditional near-infrared zone 1 imaging, near-infrared zone 2 fluorescence imaging has the advantages of small light scattering, low tissue autofluorescence, high imaging resolution and strong tissue penetration ability. If it is used in clinical practice, it will effectively solve the above-mentioned shortcomings of near-infrared zone 1 fluorescence imaging.

[0003] However, the development of near-infrared zone II imaging technology currently faces many difficulties. First, the R&D cost of near-infrared zone II imaging equipment is high and its composition is complex, including but not limited to the need for a computer host for image processing, an excitation light source for providing excitation light, a path light guide for providing excitation light, and a water-cooling machine for providing water cooling for the camera. It can be seen that its system structure and control are relatively complex and the equipment composition requires a large space, so it is difficult to apply it to the operating room for clinical use. Secondly, the R&D cost and technical difficulty of fluorescent dyes suitable for near-infrared zone II are high. However, if the existing fluorescent dyes commonly used in near-infrared zone I are used in near-infrared zone II, such as indocyanine green (ICG), the excitation light wavelength is 785nm and the emission light wavelength is strongest near 835nm. Although the fluorescent dye will also have tail fluorescence in near-infrared zone II, the fluorescence intensity is weak. Fluorescence imaging with current imaging equipment will result in poor imaging effect and low efficiency, and it is impossible to quickly find the location of the lesion and perform accurate imaging during surgery.

[0004] Therefore, it is necessary to design a compact imaging device and method that can be used for clinical near-infrared zone II precision imaging. Summary of the invention

[0005] The compact imaging device and method for clinical near-infrared zone II precision imaging provided by the present invention are mainly used to solve the problems of low detection depth, large light scattering effect, large spontaneous fluorescence and background interference of tissues in traditional near-infrared zone I imaging, and complex near-infrared zone II imaging equipment, poor imaging effect and low efficiency, so as to achieve the effect that the near-infrared zone II imaging equipment has a compact structure and can quickly and accurately locate the lesion position to achieve precise imaging.

[0006] The present invention achieves the above-mentioned purpose through the following technical solutions:

[0007] A compact imaging device for clinical near-infrared zone II precision imaging, comprising a camera device, an image processing module, a display device and a power module for powering the imaging device, wherein the camera device comprises a housing, a control module is arranged in the housing, a light outlet is arranged at the lower end of the housing, and an excitation light source module, a filter wheel assembly, a focusing assembly and a camera are arranged in sequence on a vertical axis from bottom to top, the control module is electrically connected to the excitation light source module, and is used to output a light output signal to the excitation light source module, and the excitation light source module is used to emit excitation light of a specific wavelength to an imaging area through the light outlet according to the light output signal; the filter wheel assembly is located at the front end of the camera lens, and comprises a filter wheel and a first drive device, and at least a near-infrared filter wheel is installed on the circumference of the filter wheel. The first filter of the first spectral band and the second filter of the second spectral band of the near-infrared band, the control module is electrically connected to the first driving device, and is used to successively output a first driving signal and a second driving signal to the first driving device, and the first driving device is used to successively drive the filter wheel to switch to the first filter and the second filter for filtering according to the first driving signal and the second driving signal; the focusing component is installed on the lens of the camera, and is used for focusing the camera; the camera establishes a data transmission connection with the image processing module, and is used to collect and process fluorescence, and output image data to the image processing module, and the image processing module is connected to the display device, and is used to process the image data, and output it to the display device for real-time display of the image.

[0008] A further solution is that a plurality of LED lamp beads of different wavelength bands are integrated on the excitation light source module, which are used to control the LED lamp beads matching the wavelength of the excitation light to emit light according to the light output signal.

[0009] A further solution is that the first driving device includes a first driving gear and a first driving motor, a first gear tooth is provided on the circumference of the filter wheel, the first driving gear is connected to the motor shaft of the first driving motor and meshes with the first gear tooth, and the first driving motor is electrically connected to the control module and is used to drive the filter wheel to rotate through gear transmission according to the first driving signal.

[0010] A further solution is that the emission light band of the fluorescent drug in the imaging area is within the spectral band of the near-infrared region.

[0011] A further solution is that filters of at most five different wavelength bands are provided at different positions on the circumference of the filter wheel, wherein the radiation wavelength band of the near-infrared spectral band filter is near the emission wavelength band of the corresponding fluorescent drug.

[0012] A further solution is that the focusing assembly includes a focusing ring and a second driving device, the focusing ring is installed on the lens, and is used for focusing the camera by rotation, and a second gear tooth is provided on the circumference of the focusing ring; the second driving device includes a second driving gear and a second driving motor, the second driving gear is connected to the motor shaft of the second driving motor and meshes with the second gear tooth, the control module is electrically connected to the second driving motor, and is used to output a third driving signal to the second driving motor, and the second driving motor drives the focusing ring to rotate through gear transmission according to the third driving signal.

[0013] A further solution is that both the first drive motor and the second drive motor are drive motors with encoders.

[0014] A further solution is that the camera adopts an InGaAs camera.

[0015] A further solution is to further include a control button module, which is integrated on the shell and includes a first button, a second button and a third button, each button is respectively connected to the output interface of the corresponding function of the control module, the first button is connected to the excitation light source module for manually controlling the emission of the excitation light; the second button is connected to the first drive motor for manually controlling the switching of the filter; the third button is connected to the second drive motor for manually controlling the focusing of the camera.

[0016] A method for clinical near-infrared zone II precision imaging, applied to the compact imaging device for clinical near-infrared zone II precision imaging, comprises:

[0017] S1: The device is powered on and the excitation light source module is controlled to emit excitation light of a specific wavelength to the imaging area.

[0018] S2: Filter the excited fluorescence through the first filter.

[0019] S3: collecting the fluorescence through a camera and performing fluorescence imaging to generate image data, and displaying the image data in real time after processing.

[0020] S4: Determine whether the displayed image is clear at this time. If it is clear, execute step S5; if it is not clear, control the camera to focus and repeat the previous step.

[0021] S5: Control the filter wheel to rotate until the second filter is turned to the filtering position.

[0022] S6: Filter the excited fluorescence through the second filter, and then execute step S3.

[0023] It can be seen that the present invention has the following beneficial effects:

[0024] 1. The present invention realizes high integration by integrating the control module, the excitation light source module, the filter wheel assembly, the focusing assembly and the camera in the same housing, and has a simple structure, a small size and is easy to carry. Compared with the traditional near-infrared two-zone imaging device with complex components, it is more suitable for clinical fluorescence imaging operations.

[0025] 2. A filter of the second near-infrared spectral band is arranged on the filter wheel of the present invention. The filter wheel is rotated by controlling the first driving motor to switch the filter to the filtering position to perform a second filtering on the fluorescence. Compared with the traditional near-infrared first zone imaging, the light collected by the lens at the lesion position can be more concentrated, thereby obtaining a more accurate lesion position and a fluorescence imaging area with clearer texture.

[0026] 3. The present invention adopts an InGaAs camera for fluorescence imaging acquisition, which is suitable for the near-infrared band of 900-1700nm and meets the needs of near-infrared fluorescence imaging; and it has high sensitivity, high resolution and high frame rate, which can significantly improve image quality; compared with traditional CCD / CMOS cameras, its size is relatively small, which is convenient for integration and miniaturization design.

[0027] 4. The present invention has a high degree of automation. The control module controls the excitation light emission of the excitation light source module, controls the first drive motor to drive the filter wheel to switch the filter, and controls the second drive motor to focus the lens. Compared with traditional manual operation, one-touch operation such as buttons is required to achieve control, which greatly improves the accuracy of imaging and reduces the risk of manual operation errors and errors. At the same time, it reduces the work pressure of medical staff and improves imaging efficiency.

[0028] 5. The present invention filters the emitted fluorescence by controlling the filter wheel to switch filters of different wavelengths, first filtering through a filter near the wavelength of the emitted light, thereby finding the approximate target of the lesion, and controlling the lens to focus to make the displayed image clear, and then switching to the filter of the near-infrared zone II spectrum for a second filtering, thereby achieving the purpose of quickly and accurately locating the lesion area. It can be seen that the present invention is no longer limited to the traditional scheme of using near-infrared zone II camera + near-infrared zone II lens + near-infrared zone II filter and other solutions that are completely dependent on near-infrared zone II spectral equipment, and provides a new idea for the clinical application of near-infrared zone II imaging technology.

[0029] The present invention is further described in detail below in conjunction with the accompanying drawings and specific embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 It is a schematic diagram of a compact imaging device for near-infrared zone II precision imaging according to the present invention.

[0031] Figure 2 It is a schematic diagram of the structure of the camera assembly of the present invention.

[0032] Figure 3 It is a schematic diagram of the host structure of the present invention.

[0033] Figure 4 This is a flow chart of the method for near-infrared second zone precise imaging of the present invention.

[0034] Figure 5 It is a schematic diagram of the fluorescence imaging process of the present invention. DETAILED DESCRIPTION

[0035] In order to make the purpose, technical solution and advantages of the embodiment of the present invention clearer, the technical solution of the embodiment of the present invention will be clearly and completely described below in conjunction with the drawings of the embodiment of the present invention. Obviously, the described embodiment is a part of the embodiment of the present invention, not all of the embodiments. Based on the described embodiment of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0036] Embodiment of a compact imaging device for clinical near-infrared zone II precision imaging

[0037] See also Figure 1-3The compact imaging device for clinical near-infrared zone II precision imaging involved in the present invention comprises a camera device 10, an image processing module 22, a display device 30 and a power module 24 for powering the device. The camera device 10 comprises a housing 11, a control module 12 is arranged in the housing 11, a light outlet is arranged at the lower end thereof, and an excitation light source module 13, a filter wheel assembly 14, a focusing assembly 15 and a camera 16 are sequentially arranged on a vertical axis from bottom to top. The control module 12 is electrically connected to the excitation light source module 13 and is used to output a light output signal to the excitation light source module 13. The excitation light source module 13 is used to emit excitation light of a specific wavelength to the imaging area through the light outlet according to the light output signal, so as to excite the fluorescent drug to emit fluorescence; the filter wheel assembly 14 is located at the front end of the lens of the camera 16, and comprises a filter wheel 141 and a first driving device 142. At least a first filter of a near-infrared first band and a second filter of a near-infrared second band are installed on the circumference of the filter wheel 141. The control module 12 is electrically connected to the first driving device 142, and is used to successively output a first driving signal and a second driving signal to the first driving device 142. The first driving device 142 is used to successively drive the filter wheel 141 to switch to the first filter and the second filter for filtering according to the first driving signal and the second driving signal; the focusing component 15 is installed on the lens of the camera 16, and is used for focusing the camera 16; the camera 16 establishes a data transmission connection with the image processing module 22, and is used to collect and process fluorescence, and output image data to the image processing module 22. The image processing module 22 is connected to the display device 30, and is used to perform image processing on the image data, and output it to the display device 30 for real-time display of the image.

[0038] Specifically, the handheld camera device 10 of this embodiment is composed of an integrated design of a control module 12, an excitation light source module 13, a filter wheel assembly 14, a focusing assembly 15, and a camera 16. The image processing module 22 and the power module 24 are integrated in the host 20, and the display device 30 is an independent display. Among them, the handheld camera device 10, the host 20 and the display device 30 are independent of each other. Such a split design can be freely combined according to the actual site and needs during use, which is convenient for relocation and layout to reduce the occupied space. Among them, the highly integrated design of the camera device 10 makes it smaller in size. Compared with traditional fixed imaging equipment, it can be flexibly handheld to improve imaging efficiency.

[0039] Specifically, the control module 12 of this embodiment adopts a single-chip microcomputer, which has a high degree of integration and integrates a central processing unit to play a core role in control. It exchanges and communicates data with the host 20 through various communication interfaces, such as serial port, I2C, SPI and Ethernet; it controls the excitation light source module 13, drive motor, etc. through the input and output interface to meet the needs of automated control; at the same time, the size of the single-chip microcomputer is relatively small, which meets the needs of portable design of the camera device 10.

[0040] Specifically, the housing 11 of the camera device 10 of this embodiment is cylindrical, and an opening is provided at its lower end for emitting the excitation light and collecting the fluorescence; the excitation light source module 13, the filter wheel assembly 14 and the focus assembly 15 are fixedly installed in the lower half from bottom to top, and the camera 16 is fixedly installed in the upper half, and the control module 12 is installed in parallel with the camera 16 in the housing 11. The camera device 10 has a compact structure design, and the size of the camera device 10 is further reduced by integrating the LED lamp beads of different bands on the circuit board, using a smaller camera 16 and a single-chip microcomputer, so as to facilitate handheld operation.

[0041] Specifically, the host 20 of this embodiment includes a shell 21, in which an image processing board with an integrated image processing module 22, an independent graphics card 23, a power module 24 and a water cooler 25 are installed. The image processing board is based on an operating system such as Windows or Linux, and is connected to the camera 16 through a USB interface of the host 20 to receive and communicate image data, and is used to process and analyze the image data. Its data processing calculation is based on a CPU, a GPU or an FPGA; the independent graphics card 23 is used to image the information processed by the image processing board, and is connected to a display through an HDMI interface of the host 20 so that the display can display images; the power module 24 is integrated with a power management chip, a power conversion circuit, etc., and is used to convert and distribute the input 220V external power supply, so as to provide working power for each electrical component in the host 20, the display device 30 and the camera device 10; the water cooler 25 is connected to the camera device 10 through a water cooling pipeline, and is used to cool down the heat-generating devices such as the control module 12, the drive motor, and the camera 16 to reduce noise and improve image quality.

[0042] Specifically, this embodiment further includes input devices, such as a mouse 50 and a keyboard 40 , which are connected to an input interface of the host 20 for human-computer interaction.

[0043] Specifically, the split design of the imaging device in the present embodiment is only exemplary, not the only way, and can be integrated according to actual needs. For example, the display can be a touch screen integrated on the housing 21 of the host 20; the host 20, the camera 10 and the display can be integrated into the same device, and the control of the excitation light source module 13 and the drive motor and the data communication with the camera 16 can be realized simultaneously through the same main control module. The split design of the present embodiment is only the best solution designed considering the portable function of the camera 10.

[0044] In this embodiment, the excitation light source module 13 is integrated with a plurality of LED lamp beads of different wavelength bands, which are used to control the LED lamp beads matching the wavelength of the excitation light to emit light according to the light output signal.

[0045] Specifically, the excitation light source module 13 of this embodiment is a ring-shaped circuit board, and its hollow circle is aligned with the filtering position of the filter wheel 141 and the lens of the camera 16 on the vertical axis.

[0046] Specifically, in this embodiment, the LED lamp beads of several different bands are integrated on the annular circuit board by welding.

[0047] Specifically, this embodiment controls the on and off of LED lamp beads of corresponding wavelengths through a single chip microcomputer, thereby realizing the replacement of the excitation light wavelength; or controls the magnitude of the excitation light power by controlling the magnitude of the current of LED lamp beads of a certain wavelength.

[0048] Specifically, the use of an integrated circuit board in the excitation light source module 13 of this embodiment is only exemplary and not the only way. For example, a laser can also be used as an excitation light source and installed at the front end of the camera device 10. The design of the integrated circuit board in this embodiment is only the best solution considering the integrated design of the camera device 10.

[0049] In this embodiment, the first driving device 142 includes a first driving gear and a first driving motor. A first gear tooth is provided on the circumference of the filter wheel 141. The first driving gear is connected to the motor shaft of the first driving motor and meshes with the first gear tooth. The first driving motor is electrically connected to the control module 12 and is used to drive the filter wheel 141 to rotate through gear transmission according to the first driving signal.

[0050] Specifically, in this embodiment, the first driving gear and the first gear tooth have the same module.

[0051] In this embodiment, at least a first filter and a second filter are arranged at different positions on the circumference of the filter wheel 141. The radiation band of the first filter is close to the emission light band of the fluorescent drug, and the radiation band of the second filter is within the spectral band of the near-infrared region II.

[0052] In this embodiment, the emission light band of the fluorescent drug is within the spectral band of the near-infrared region.

[0053] In this embodiment, the initial state of the filter wheel 141 is: the first filter is located at the filtering position, and the second filter is located at the non-filtering position.

[0054] The state of the filter wheel 141 after rotation is: the second filter is located at the filtering position, and the first filter is located at the non-filtering position.

[0055] The filtering position is the front end of the lens of the camera 16 .

[0056] Specifically, the structure of the filter wheel 141 of the present embodiment is only exemplary and not the only way. For example, multiple filters of different bands can be loaded on the filter wheel 141 at the same time, including at least one filter in the near-infrared zone II band. According to the band of the light emitted by the fluorescent drug, the filter of the corresponding band is selected for the first filtering, and the filter in the near-infrared zone II band is switched by rotating the filter wheel 141 for the second filtering. By controlling the first drive motor, the filter wheel 141 can be rotated to automatically change the filter according to different fluorescent drugs, which is convenient and fast to operate, and further improves the imaging efficiency; and after the approximate target of the lesion is first found by the first filter, the filter of the near-infrared zone II spectrum band is switched to accurately locate the lesion, so as to achieve the effect of quickly and accurately locating the lesion position and thus accurately imaging.

[0057] In this embodiment, the focusing assembly 15 includes a focusing ring 151 and a second driving device 152. The focusing ring 151 is installed on the lens and is used to focus the camera 16 by rotation. A second gear is provided on its circumference; the second driving device 152 includes a second driving gear and a second driving motor. The second driving gear is connected to the motor shaft of the second driving motor and meshes with the second gear. The control module 12 is electrically connected to the second driving motor and is used to output a third driving signal to the second driving motor. The second driving motor drives the focusing ring 151 to rotate through gear transmission according to the third driving signal.

[0058] Specifically, in this embodiment, the second driving gear and the second gear teeth have the same module.

[0059] Specifically, in this embodiment, the first drive motor and the second drive motor both use drive motors with encoders, and the encoders are used to provide real-time feedback on the motor's motion state and position information, to achieve high-precision positioning and control, so that the filter can be accurately switched to the specified filtering position; and the camera 16 can achieve high-precision focusing, thereby ensuring the clarity and accuracy of the image.

[0060] In this embodiment, the camera 16 is an InGaAs camera.

[0061] Specifically, the indium gallium arsenide (InGaAs) camera used in this embodiment can be applied to the near-infrared band of 900-1700nm, has the advantages of high sensitivity, high resolution and high frame rate, and supports multiple data transmission interfaces such as EIA and USB 3.0, which facilitates high-speed data transmission and processing.

[0062] In this embodiment, a control button module 17 is also included. The control button module 17 is integrated on the shell 11, and includes a first button, a second button and a third button. Each button is respectively connected to the output interface of the corresponding function of the control module 12. The first button is connected to the excitation light source module 13 for manually controlling the emission of the excitation light; the second button is connected to the first drive motor for manually controlling the switching of the filter; the third button is connected to the second drive motor for manually controlling the focusing of the camera 16.

[0063] Specifically, the manual operation control using the control button module 17 in this embodiment is only exemplary and not the only control method. For example, a control program can be set inside the single-chip microcomputer to automatically execute the control of the excitation light source module 13, the drive motor, etc. with one click; the host 20 communicates with the single-chip microcomputer and remotely controls by operating the keyboard 40, the mouse 50 or the touch screen; this embodiment is designed with control buttons for the convenience of handheld operation of the camera device 10, which is convenient for flexible operation on site.

[0064] Method embodiment for clinical near-infrared zone two precise imaging

[0065] See also Figure 4 The method for clinical near-infrared zone II precision imaging involved in the present invention is applied to the compact imaging device for clinical near-infrared zone II precision imaging, comprising:

[0066] S1: The device is powered on, and the excitation light source module 13 is controlled to emit excitation light of a specific wavelength to the imaging area.

[0067] S2: Filter the excited fluorescence through the first filter.

[0068] S3: The fluorescence is collected by the camera 16 and fluorescence imaging is performed to generate image data, and the image data is processed and displayed in real time.

[0069] S4: Determine whether the displayed image is clear at this time. If it is clear, execute step S5; if it is not clear, control the camera 16 to focus and repeat the previous step.

[0070] S5: Control the filter wheel 141 to rotate until the second filter is turned to the filtering position.

[0071] S6: Filter the excited fluorescence through the second filter, and then execute step S3.

[0072] See also Figure 5 Specifically, this embodiment uses indocyanine green (ICG) fluorescent developer as an example to further illustrate that the excitation peak of indocyanine green is about 780nm and the emission peak is about 830nm. During the operation, the lens of the camera device 10 is aimed at the lesion area located before the operation; the system is powered on, and the excitation light source module 13 is controlled to emit 785nm band excitation light, and indocyanine green is excited to fluoresce (because the wavelength of the excitation light is near the excitation peak of indocyanine green, indocyanine green can absorb the maximum amount of light energy and reach the highest excited state at this time, and can achieve a higher emission light intensity with the lowest possible excitation light power); the filter wheel 141 is controlled to switch the 900nm long-wave pass filter to the filtering position, that is, to align the light source ring circuit board. ; observe the image clarity on the display screen to control the focus of the camera 16 until the image is clear (at this time, a brighter fluorescent development of the lesion will be seen on the display, but the development area is relatively large and the boundary is not clear. The purpose at this time is only to find the approximate target of the lesion); control the filter wheel 141 to switch the filter with a wavelength in the near-infrared second zone (such as a filter of 1100nm or 1200nm) to the filtering position. It can be seen from the figure that the scattering angle of the emitted light transmitted by the 1200nm filter is much smaller than that of the 900nm filter. The light collected by the camera 16 through the lens is more concentrated in the area centered on the lesion. Therefore, at this time, a fluorescent imaging area with a more accurate lesion position and clearer texture will be seen on the display.

[0073] The above-mentioned embodiments are only preferred embodiments of the present invention and cannot be used to limit the scope of protection of the present invention. Any non-substantial changes and substitutions made by technicians in this field on the basis of the present invention shall fall within the scope of protection required by the present invention.

Claims

1. A compact imaging device for clinical near-infrared zone II precision imaging, comprising a camera device, an image processing module, a display device, and a power module for powering the imaging device, characterized in that: The camera device comprises: A shell, wherein a control module is arranged in the shell, a light outlet is arranged at the lower end thereof, and an excitation light source module, a filter wheel assembly, a focusing assembly and a camera are arranged in sequence on a vertical axis from bottom to top, wherein the control module is electrically connected to the excitation light source module and is used to output a light output signal to the excitation light source module, and the excitation light source module is used to emit excitation light of a specific wavelength to an imaging area through the light outlet according to the light output signal; the filter wheel assembly is located at the front end of the lens of the camera, and comprises a filter wheel and a first driving device, wherein at least a first filter of a near-infrared first spectral band and a second filter of a near-infrared second spectral band are installed on the circumference of the filter wheel, and the control module is electrically connected to the excitation light source module and is used to output a light output signal to the excitation light source module, and the excitation light source module is used to emit an excitation light of a specific wavelength to an imaging area through the light output port according to the light output signal; the filter wheel assembly is located at the front end of the lens of the camera, and comprises a filter wheel and a first driving device, and at least a first filter of a near-infrared first spectral band and a second filter of a near-infrared second spectral band are installed on the circumference of the filter wheel, and the control module is electrically connected to the excitation light source module and is used to output a light output signal to the excitation light source module, and the excitation light source module is used to emit an excitation light of a specific wavelength to an imaging area through the light output port according to the light output signal; the filter wheel assembly The first driving device is electrically connected and is used to output a first driving signal and a second driving signal to the first driving device in sequence. The first driving device is used to drive the filter wheel to switch to the first filter and the second filter for filtering in sequence according to the first driving signal and the second driving signal; the focusing component is installed on the lens of the camera and is used for focusing the camera; the camera establishes a data transmission connection with the image processing module, which is used to collect and process fluorescence and output image data to the image processing module; the image processing module is connected with the display device, which is used to process the image data and output it to the display device for real-time display of the image.

2. The compact imaging device for near-infrared second-zone precision imaging according to claim 1, characterized in that: The excitation light source module is integrated with a plurality of LED lamp beads of different wavelength bands, which are used to control the LED lamp beads matching the wavelength of the excitation light to emit light according to the light output signal.

3. The compact imaging device for near-infrared second-zone precision imaging according to claim 1, characterized in that: The first driving device includes a first driving gear and a first driving motor. A first gear tooth is provided on the circumference of the filter wheel. The first driving gear is connected to the motor shaft of the first driving motor and meshes with the first gear tooth. The first driving motor is electrically connected to the control module and is used to drive the filter wheel to rotate through gear transmission according to the first driving signal.

4. The compact imaging device for near-infrared second-zone precise imaging according to claim 1, characterized in that: The emission light band of the fluorescent drug in the imaging area is within the spectral band of the near-infrared region.

5. The compact imaging device for near-infrared second-zone precise imaging according to claim 4, characterized in that: At most five filters of different wavelength bands are arranged at different positions on the circumference of the filter wheel, wherein the radiation wavelength band of the near-infrared spectral band filter is near the emission wavelength band of the corresponding fluorescent drug.

6. The compact imaging device for near-infrared second-zone precise imaging according to claim 1, characterized in that: The focusing assembly includes a focusing ring and a second driving device. The focusing ring is installed on the lens and is used to focus the camera by rotation. The circumference of the focusing ring is provided with second gear teeth. The second driving device includes a second driving gear and a second driving motor. The second driving gear is connected to the motor shaft of the second driving motor and meshes with the second gear teeth. The control module is electrically connected to the second driving motor and is used to output a third driving signal to the second driving motor. The second driving motor drives the focusing ring to rotate through gear transmission according to the third driving signal.

7. The compact imaging device for near-infrared second-zone precise imaging according to any one of claims 3 or 6, characterized in that: The first drive motor and the second drive motor are both drive motors with encoders.

8. The compact imaging device for near-infrared second-zone precision imaging according to claim 1, characterized in that: The camera adopts an InGaAs camera.

9. The compact imaging device for near-infrared second-zone precision imaging according to any one of claims 1 to 8, characterized in that: It also includes a control button module, which is integrated on the shell and includes a first button, a second button and a third button. Each button is connected to an output interface of a corresponding function of the control module, respectively. The first button is connected to the excitation light source module for manually controlling the emission of the excitation light; the second button is connected to the first drive motor for manually controlling the switching of the filter; the third button is connected to the second drive motor for manually controlling the focusing of the camera.

10. A method for clinical near-infrared zone II precision imaging, characterized in that: A compact imaging device for clinical near-infrared zone 2 precision imaging as claimed in any one of claims 1 to 9, comprising: S1: The device is powered on and the excitation light source module is controlled to emit excitation light of a specific wavelength to the imaging area; S2: filtering the excited fluorescence through the first filter; S3: collecting the fluorescence through a camera and performing fluorescence imaging to generate image data, and displaying the image data in real time after processing; S4: Determine whether the displayed image is clear at this time. If it is clear, execute step S5; if it is not clear, control the camera to focus and repeat the previous step; S5: controlling the filter wheel to rotate until the second filter is turned to a filtering position; S6: Filter the excited fluorescence through the second filter, and then execute step S3.

Images