Veterinary florfenicol solution as well as preparation method and application thereof

Abstract

The invention provides a florfenicol solution for veterinary use as well as a preparation method and application of the florfenicol solution for veterinary use. The mass percent of the florfenicol is 20%-35%, the mass percent of the inclusion agent is 6%-15%, the mass percent of the cosolvent is 5%-10%, the mass percent of the solubilizer is 10%-15%, the mass percent of the wetting agent is 0.05%-0.2%, the mass percent of the pH regulator is 0.8%-1.5%, the mass percent of the antioxidant is 0.8%-2.5%, and the mass percent of the flavoring agent is 1.0%-5.0%. The veterinary florfenicol solution disclosed by the invention is simple in preparation process, relatively good in solubility of florfenicol, clear in solution and free from precipitation after being placed for a long time. Test results show that the veterinary florfenicol solution has a remarkable treatment effect on chicken colibacillosis, and can effectively control symptoms of swine enzootic pneumonia and improve the mental state and the respiratory rate.

Description

Technical Field

[0001] The invention relates to the technical field of veterinary drugs, and in particular to a veterinary florfenicol solution and a preparation method and application thereof. Background Art

[0002] Florfenicol, also known as fluorosulfamic acid, is an acylamino alcohol antibacterial drug for animals and has been widely used in my country's breeding industry. The drug was developed by Schering-Plough in the United States in the late 1970s. It is an upgraded product of chloramphenicol and thiamphenicol, which is derived from the substitution of fluorine atoms for the hydroxyl group at the 3-carbon position of the propane chain in thiamphenicol. Chloramphenicol has been rarely used because of its serious adverse reactions to the hematopoietic system; while florfenicol has no potential to cause aplastic anemia, teratogenicity, carcinogenicity and mutagenicity. Its antibacterial spectrum and antibacterial activity are superior to chloramphenicol and thiamphenicol, which can be up to 10 times that of thiamphenicol. It still has antibacterial activity against bacteria resistant to chloramphenicol and thiamphenicol, and has broad application prospects.

[0003] Florfenicol is a new type of antibiotic specifically used for animals, and is used to treat mycoplasma and thiamphenicol-resistant bacteria. It is often used to treat diseases caused by streptococci. It has no residue or very low residue in the body and is widely used in clinical practice.

[0004] Florfenicol can be used to treat porcine contagious pleuropneumonia caused by Actinobacillus pleuropneumoniae. In Japan and Mexico, it is mainly used to prevent and treat porcine bacterial diseases, and is also used as a pig feed premix.

[0005] Florfenicol has poor water solubility and low bioavailability, which limits its efficacy and brings inconvenience to clinical use. Currently, the main preparations of florfenicol include injection, soluble powder, solution and premix. Different preparations have different application purposes and their efficacy also varies to a certain extent. Summary of the invention

[0006] The present invention aims to provide a veterinary florfenicol solution and a preparation method and application thereof.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions: The first aspect of the present invention provides a veterinary florfenicol solution, which is composed of the following components: florfenicol, a inclusion agent, a cosolvent, a solubilizer, a wetting agent, a pH regulator, an antioxidant and a flavoring agent.

[0008] Preferably, in the veterinary florfenicol solution of the present invention, the mass percentage of florfenicol is 20%-35%, the mass percentage of the inclusion agent is 6%-15%, the mass percentage of the co-solvent is 5%-10%, the mass percentage of the solubilizer is 10%-15%, the mass percentage of the wetting agent is 0.05%-0.2%, the mass percentage of the pH regulator is 0.8%-1.5%, the mass percentage of the antioxidant is 0.8%-2.5% and the mass percentage of the flavoring agent is 1.0%-5.0%.

[0009] Preferably, the inclusion agent is hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin in a mass ratio of 1:1-3:2-5.

[0010] Preferably, the co-solvent is propylene glycol and polyethylene glycol 400 in a mass ratio of 1:2-4.

[0011] Preferably, the solubilizer is hypromellose.

[0012] Preferably, the wetting agent is dextran or ammonium alginate.

[0013] Preferably, the pH adjuster is lactic acid-sodium lactate.

[0014] Preferably, the antioxidant is sodium metabisulfite.

[0015] Preferably, the flavoring agent is maltitol.

[0016] A preferred prescription of the present invention is: 25 g of florfenicol, 10 g of hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin in a mass ratio of 1:2:4, 8 g of propylene glycol and polyethylene glycol 400 in a mass ratio of 1:3, 12 g of hypromellose, 0.1 g of dextran, 0.93 mg of lactic acid, 1.0 g of sodium lactate, 1.5 g of sodium metabisulfite and 3.0 g of maltitol.

[0017] Another preferred prescription of the present invention is: 25 g of florfenicol, 10 g of hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin in a mass ratio of 1:2:4, 8 g of propylene glycol and polyethylene glycol 400 in a mass ratio of 1:3, 12 g of hypromellose, 0.1 g of ammonium alginate, 0.93 mg of lactic acid, 1.0 g of sodium lactate, 1.5 g of sodium metabisulfite and 3.0 g of maltitol.

[0018] The second aspect of the present invention provides a method for preparing the above-mentioned veterinary florfenicol solution, comprising the following steps: Under stirring conditions, the cosolvent is dissolved in water, and an antioxidant and a flavoring agent are added to obtain a mixture 1; at a temperature of 45° C. to 55° C., florfenicol and a wetting agent, a inclusion agent, and a solubilizing agent are uniformly mixed to obtain a mixture 2; the mixture 1 and the mixture 2 are mixed, cooled, and defoamed; a pH adjuster is added to adjust the pH of the solution to 6.0-7.0, and a veterinary florfenicol solution is obtained.

[0019] Preferably, the temperature is 50°C.

[0020] Preferably, the pH of the florfenicol solution is 6.5.

[0021] The third aspect of the present invention provides the use of the above-mentioned veterinary florfenicol solution in the preparation of veterinary drugs.

[0022] Compared with the prior art, the present invention has the following beneficial effects: The veterinary florfenicol solution of the invention has a simple preparation process, good florfenicol solubility, a clear solution, and no precipitation after long-term storage.

[0023] The florfenicol solution of the present invention has a significant therapeutic effect on chicken Escherichia coli disease. The veterinary florfenicol solution of the present invention can effectively control the symptoms of pig panting disease and improve the mental state and respiratory rate. Specific embodiments The content of the present invention is further described in detail below through specific implementation methods, but this should not be understood as the scope of the above subject matter of the present invention is limited to the following examples. The following examples are used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. If a person of ordinary skill in the art modifies or replaces the technical solution of the present invention with an equivalent without departing from the essence and scope of the technical solution of the present invention, it still belongs to the scope of protection of the present invention.

[0025] Example 1 A veterinary florfenicol solution is prepared by the following method: Florfenicol 30g, hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin in a mass ratio of 1:2:4 10g, propylene glycol and polyethylene glycol 400 in a mass ratio of 1:3 8g, hypromellose 12g, dextran 0.1g, lactic acid 0.93mg, sodium lactate 1.0g, sodium metabisulfite 1.5g and maltitol 3.0g.

[0026] Under stirring conditions, propylene glycol and polyethylene glycol 400 are dissolved in water, and sodium metabisulfite and maltitol are added to obtain mixture 1; at 50°C, florfenicol and dextran, hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin, and hydroxypropyl methylcellulose are uniformly mixed to obtain mixture 2; mixture 1 and mixture 2 are mixed, cooled, and defoamed; lactic acid-sodium lactate is added to adjust the pH of the solution to 6.5, thereby obtaining veterinary florfenicol solution.

[0027] Example 2 A veterinary florfenicol solution is prepared by the following method: Florfenicol 30g, hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin in a mass ratio of 1:2:4 10g, propylene glycol and polyethylene glycol 400 in a mass ratio of 1:3 8g, hypromellose 12g, ammonium alginate 0.1g, lactic acid 0.93mg, sodium lactate 1.0g, sodium metabisulfite 1.5g and maltitol 3.0g.

[0028] Under stirring conditions, propylene glycol and polyethylene glycol 400 are dissolved in water, and sodium metabisulfite and maltitol are added to obtain mixture 1; at 45°C, florfenicol and ammonium alginate, hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin, and hydroxypropyl methylcellulose are uniformly mixed to obtain mixture 2; mixture 1 and mixture 2 are mixed, cooled, and defoamed; lactic acid-sodium lactate is added to adjust the pH of the solution to 6.0, thereby obtaining veterinary florfenicol solution.

[0029] Example 3 A veterinary florfenicol solution is prepared by the following method: Florfenicol 25g, hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin in a mass ratio of 1:3:5 10g, propylene glycol and polyethylene glycol 400 in a mass ratio of 1:2 8g, hypromellose 15g, dextran 0.05g, lactic acid 0.93mg, sodium lactate 1.0g, sodium metabisulfite 2.5g and maltitol 2.0g.

[0030] Under stirring conditions, propylene glycol and polyethylene glycol 400 are dissolved in water, and sodium metabisulfite and maltitol are added to obtain mixture 1; at 55° C., florfenicol and dextran, hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin, and hydroxypropyl methylcellulose are uniformly mixed to obtain mixture 2; mixture 1 and mixture 2 are mixed, cooled, and defoamed; lactic acid-sodium lactate is added to adjust the pH of the solution to 7.0, thereby obtaining veterinary florfenicol solution.

[0031] Example 4 A veterinary florfenicol solution is prepared by the following method: Florfenicol 20g, hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin in a mass ratio of 1:1:2 10g, propylene glycol and polyethylene glycol 400 8g in a mass ratio of 1:4, hypromellose 10g, ammonium alginate 0.05g, lactic acid 0.93mg, sodium lactate 1.0g, sodium metabisulfite 0.8g and maltitol 3.0g.

[0032] Under stirring conditions, propylene glycol and polyethylene glycol 400 are dissolved in water, and sodium metabisulfite and maltitol are added to obtain mixture 1; at 45°C, florfenicol and ammonium alginate, hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin, and hydroxypropyl methylcellulose are uniformly mixed to obtain mixture 2; mixture 1 and mixture 2 are mixed, cooled, and defoamed; lactic acid-sodium lactate is added to adjust the pH of the solution to 6.8, thereby obtaining veterinary florfenicol solution.

[0033] Example 5 A veterinary florfenicol solution is prepared by the following method: Florfenicol 30g, hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin in a mass ratio of 1:2:4 10g, propylene glycol and polyethylene glycol 400 in a mass ratio of 1:4 8g, hypromellose 12g, dextran 0.2g, lactic acid 0.93mg, sodium lactate 1.0g, sodium metabisulfite 2.0g and maltitol 5.0g.

[0034] Under stirring conditions, propylene glycol and polyethylene glycol 400 are dissolved in water, and sodium metabisulfite and maltitol are added to obtain mixture 1; at 50°C, florfenicol and dextran, hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin, and hydroxypropyl methylcellulose are uniformly mixed to obtain mixture 2; mixture 1 and mixture 2 are mixed, cooled, and defoamed; lactic acid-sodium lactate is added to adjust the pH of the solution to 6.0, thereby obtaining veterinary florfenicol solution.

[0035] Example 6 A veterinary florfenicol solution is prepared by the following method: Florfenicol 35g, hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin in a mass ratio of 1:3:4 10g, propylene glycol and polyethylene glycol 400 8g in a mass ratio of 1:2, hypromellose 15g, ammonium alginate 0.2g, lactic acid 0.93mg, sodium lactate 1.0g, sodium metabisulfite 1.5g and maltitol 1.0g.

[0036] Under stirring conditions, propylene glycol and polyethylene glycol 400 are dissolved in water, and sodium metabisulfite and maltitol are added to obtain mixture 1; at 55° C., florfenicol and ammonium alginate, hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin, and hydroxypropyl methylcellulose are uniformly mixed to obtain mixture 2; mixture 1 and mixture 2 are mixed, cooled, and defoamed; lactic acid-sodium lactate is added to adjust the pH of the solution to 7.0, thereby obtaining veterinary florfenicol solution.

[0037] Comparative Example 1 Prepared by the following method: Florfenicol 30g, hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin in a mass ratio of 1:4:6 10g, propylene glycol and polyethylene glycol 400 in a mass ratio of 1:3 8g, hypromellose 12g, dextran 0.1g, lactic acid 0.93mg, sodium lactate 1.0g, sodium metabisulfite 1.5g and maltitol 3.0g.

[0038] The preparation method is similar to that of Example 1.

[0039] Compared with Example 1, the difference of this comparative example is that the dosage of each component of the inclusion agent is different.

[0040] Comparative Example 2 Prepared by the following method: Florfenicol 30g, hydroxypropyl-β-cyclodextrin and β-cyclodextrin 10g in a mass ratio of 1:4, propylene glycol and polyethylene glycol 400 8g in a mass ratio of 1:3, hypromellose 12g, dextran 0.1g, lactic acid 0.93mg, sodium lactate 1.0g, sodium metabisulfite 1.5g and maltitol 3.0g.

[0041] The preparation method is similar to that of Example 1.

[0042] Compared with Example 1, the difference of this comparative example is that the type of inclusion agent is different.

[0043] Comparative Example 3 Prepared by the following method: Florfenicol 30g, hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin in a mass ratio of 1:2:4 10g, ethanol and polyethylene glycol 400 in a mass ratio of 1:3 8g, hypromellose 12g, dextran 0.1g, lactic acid 0.93mg, sodium lactate 1.0g, sodium metabisulfite 1.5g and maltitol 3.0g.

[0044] The preparation method is similar to that of Example 1.

[0045] Compared with Example 1, the difference of this comparative example is that the type of co-solvent is different.

[0046] Comparative Example 4 Prepared by the following method: Florfenicol 30g, hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin in a mass ratio of 1:2:4 10g, propylene glycol and polyethylene glycol 400 in a mass ratio of 1:3 8g, Tween 80 12g, dextran 0.1g, lactic acid 0.93mg, sodium lactate 1.0g, sodium metabisulfite 1.5g and maltitol 3.0g.

[0047] The preparation method is similar to that of Example 1.

[0048] Compared with Example 1, the difference of this comparative example is that the type of solubilizing agent is different.

[0049] Comparative Example 5 Prepared by the following method: Florfenicol 30g, hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin in a mass ratio of 1:2:4 10g, propylene glycol and polyethylene glycol 400 in a mass ratio of 1:3 8g, hypromellose 12g, dextran 0.1g, lactic acid 0.93mg, sodium lactate 1.0g, vitamin C 1.5g and maltitol 3.0g.

[0050] The preparation method is similar to that of Example 1.

[0051] Compared with Example 1, the difference of this comparative example is that the type of antioxidant is different.

[0052] Comparative Example 6 Prepared by the following method: Florfenicol 30g, hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin in a mass ratio of 1:2:4 10g, propylene glycol and polyethylene glycol 400 in a mass ratio of 1:3 8g, hypromellose 12g, dextran 0.1g, citric acid 0.93mg, sodium citrate 1.0g, sodium metabisulfite 1.5g and maltitol 3.0g.

[0053] The preparation method is similar to that of Example 1.

[0054] Compared with Example 1, the difference of this comparative example is that the type of pH regulator is different.

[0055] Physical experiment: water dissolution test stability The samples of Example 1, Example 2, Comparative Example 1, Comparative Example 2, Comparative Example 3, Comparative Example 4, Comparative Example 5 and Comparative Example 6 were dissolved in 300 times of water and placed at room temperature for 6h, 12h, 18h and 24h to observe the precipitation. The test results are shown in Table 1.

[0056] Table 1 Water stability at room temperature Effect Example 1 Experiment on the treatment of chicken Escherichia coli disease with the veterinary florfenicol solution of the present invention 400 Hy-Line Brown chickens diagnosed with Escherichia coli disease were divided into 8 groups, 50 chickens in each group. Group 1, group 2, group 3, group 4, group 5, group 6, group 7 and group 8 were treated with medication.

[0057] Group 1 was administered with drinking water according to 0.2 mL / L of the veterinary florfenicol solution of Example 1; Group 2 was administered with drinking water according to 0.2 mL / L of the veterinary florfenicol solution of Example 2; Group 3 was administered with drinking water according to 0.2 mL / L of the sample of Comparative Example 1; Group 4 was administered with drinking water according to 0.2 mL / L of the sample of Comparative Example 2; Group 5 was administered with drinking water according to 0.2 mL / L of the sample of Comparative Example 3; Group 6 was administered with drinking water according to 0.2 mL / L of the sample of Comparative Example 4; Group 7 was administered with drinking water according to 0.2 mL / L of the sample of Comparative Example 5; Group 8 was administered with drinking water according to 0.2 mL / L of the sample of Comparative Example 6.

[0058] Ten days after drug treatment, the various clinical manifestations and deaths of chickens were observed and recorded every day.

[0059] Table 2 The therapeutic effect of the veterinary florfenicol solution of the present invention on chicken Escherichia coli disease The effective rates of Group 1 and Group 2 were 98.0% and 96.0%, respectively; the effects of Group 1 and Group 2 in treating chicken Escherichia coli disease were better than those of Group 3, Group 4, Group 5, Group 6, Group 7, and Group 8.

[0060] The test results show that the veterinary florfenicol solution of the present invention has a significant therapeutic effect on chicken Escherichia coli disease.

[0061] Effect Example 2 Clinical trial of the veterinary florfenicol solution of the present invention in treating swine panting disease A total of 240 sick pigs were confirmed to be suffering from panting and were divided into 8 groups, with 30 pigs in each group. Group 1, group 2, group 3, group 4, group 5, group 6, group 7 and group 8 were given medication.

[0062] Group 1 was administered with drinking water according to 0.8 mL / L of the veterinary florfenicol solution of Example 1; Group 2 was administered with drinking water according to 0.8 mL / L of the veterinary florfenicol solution of Example 2; Group 3 was administered with drinking water according to 0.8 mL / L of the sample of Comparative Example 1; Group 4 was administered with drinking water according to 0.8 mL / L of the sample of Comparative Example 2; Group 5 was administered with drinking water according to 0.8 mL / L of the sample of Comparative Example 3; Group 6 was administered with drinking water according to 0.8 mL / L of the sample of Comparative Example 4; Group 7 was administered with drinking water according to 0.8 mL / L of the sample of Comparative Example 5; Group 8 was administered with drinking water according to 0.8 mL / L of the sample of Comparative Example 6.

[0063] 4 days after drug treatment, the respiratory status of each group of pigs after treatment was recorded, divided into appetite, panting, and coughing, and their mental status was scored. Cured: panting and coughing completely disappeared, appetite, spirit, breathing were normal, and there was no sign of recurrence. Effective: panting and coughing improved, appetite, spirit, breathing returned to normal, and there was no sign of recurrence. Ineffective: panting and coughing did not completely disappear, and there was no obvious change in appetite, spirit, and breathing or signs of aggravation. Effective rate = (cured + effective) / total number of cases × 100%, calculated and compared.

[0064] The test results are shown in Tables 3 and 4.

[0065] Table 3 The therapeutic effect of the veterinary florfenicol solution of the present invention on swine panting disease The effective rates of Group 1 and Group 2 were 98.0% and 96.0% respectively; the effects of Group 1 and Group 2 in treating swine wheezing disease were better than those of Group 3, Group 4, Group 5, Group 6, Group 7 and Group 8.

[0066] Table 4 Effect of the veterinary florfenicol solution of the present invention on the mental state and respiratory rate of swine panting disease The veterinary florfenicol solution of the present invention can effectively control the symptoms of swine panting disease and improve the mental state and respiratory rate. The therapeutic effects of Example 1 and Example 2 are significantly better than those of the comparative example group.

[0067] The above embodiments are not any form of limitation to the present invention. For those skilled in the art, any modification, replacement, etc. made within the scope of the technical solution of the present invention based on the technical essence of the present invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. A veterinary florfenicol solution, characterized in that: The veterinary florfenicol solution is composed of the following components: florfenicol, inclusion agent, cosolvent, solubilizer, wetting agent, pH regulator, antioxidant and flavoring agent; The mass percentage of the florfenicol is 20%-35%, the mass percentage of the inclusion agent is 6%-15%, the mass percentage of the co-solvent is 5%-10%, the mass percentage of the solubilizer is 10%-15%, the mass percentage of the wetting agent is 0.05%-0.2%, the mass percentage of the pH adjuster is 0.8%-1.5%, the mass percentage of the antioxidant is 0.8%-2.5% and the mass percentage of the flavoring agent is 1.0%-5.0%.

2. The veterinary florfenicol solution according to claim 1, characterized in that: The inclusion agent is hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin in a mass ratio of 1:1-3:2-5.

3. The veterinary florfenicol solution according to claim 1, characterized in that: The co-solvent is propylene glycol and polyethylene glycol 400 in a mass ratio of 1:2-4.

4. The veterinary florfenicol solution according to claim 1, characterized in that: The solubilizing agent is hypromellose.

5. The veterinary florfenicol solution according to claim 1, characterized in that: The wetting agent is dextran or ammonium alginate; the pH regulator is lactic acid-sodium lactate; the antioxidant is sodium pyrosulfite; and the flavoring agent is maltitol.

6. The veterinary florfenicol solution according to claim 1, characterized in that: The veterinary florfenicol solution includes 25g of florfenicol, 10g of hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin in a mass ratio of 1:2:4, 8g of propylene glycol and polyethylene glycol 400 in a mass ratio of 1:3, 12g of hypromellose, 0.1g of dextran, 0.93mg of lactic acid, 1.0g of sodium lactate, 1.5g of sodium metabisulfite and 3.0g of maltitol.

7. The veterinary florfenicol solution according to claim 1, characterized in that: The veterinary florfenicol solution includes 25g of florfenicol, 10g of hydroxypropyl-β-cyclodextrin, sulfobutyl-β-cyclodextrin and β-cyclodextrin in a mass ratio of 1:2:4, 8g of propylene glycol and polyethylene glycol 400 in a mass ratio of 1:3, 12g of hypromellose, 0.1g of ammonium alginate, 0.93mg of lactic acid, 1.0g of sodium lactate, 1.5g of sodium pyrosulfite and 3.0g of maltitol.

8. The veterinary florfenicol solution according to claim 1, characterized in that: The preparation method of veterinary florfenicol comprises the following steps: dissolving a cosolvent in water under stirring conditions, adding an antioxidant and a flavoring agent to obtain a mixture 1; uniformly mixing florfenicol with a wetting agent, a inclusion agent and a solubilizing agent at a temperature of 45° C. to 55° C. to obtain a mixture 2; mixing the mixture 1 and the mixture 2, cooling and defoaming; and adding a pH adjuster to adjust the pH of the solution to 6.0-7.0 to obtain a veterinary florfenicol solution.

9. Use of the veterinary florfenicol solution according to any one of claims 1 to 7 in the preparation of veterinary drugs.

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