Foot bath powder capable of dispelling wind, promoting blood circulation and dredging collaterals and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine health-care products, and particularly relates to foot bath powder capable of dispelling wind, promoting blood circulation and dredging collaterals and a preparation method thereof. The foot bath powder comprises the following components in parts by weight: 10-12 parts of ginger powder, 9-12 parts of wormwood powder, 8-10 parts of angelica sinensis powder, 5-8 parts of safflower powder, 6-8 parts of ligusticum wallichii powder, 5-8 parts of semiliquidambar cathayensis, 6-8 parts of garden balsam stem, 5-7 parts of verbena, 18-25 parts of sodium alginate, 6-12 parts of polyvinyl alcohol, 6-9 parts of beta-cyclodextrin, 6-8 parts of magnesium sulfate, 9-15 parts of sodium bicarbonate, 15-20 parts of composite sodium peroxycarbonate, 9-12 parts of sea salt, 5-7 parts of hydroxypropyl methyl cellulose and 3-5 parts of magnesium stearate. 4 parts of a humectant and 1-2 parts of an antioxidant; the traditional Chinese medicine nano-microspheres are prepared through a spray drying method, and uniform distribution of traditional Chinese medicine ingredients is promoted; the nanoparticles and the magnesium sulfate electrolyte have a synergistic effect, so that the skin permeability and blood circulation of the traditional Chinese medicine components are enhanced, and the foot bath curative effect is improved.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine health products, and particularly relates to a foot bath powder for dispelling wind, activating blood circulation and unblocking meridians and a preparation method thereof. Background Art

[0002] In the traditional theoretical system of traditional Chinese medicine, dispelling wind and activating blood circulation is one of the important ways to maintain good health. The pace of modern life is accelerating, and people are under pressure from work, family and society. Long-term mental stress and physical fatigue can lead to poor circulation of qi and blood, which in turn causes a series of health problems, such as muscle soreness, joint stiffness, insomnia, mood swings, etc. Dispelling wind and activating blood circulation is to improve the circulation of qi and blood and promote the body's internal self-regulation mechanism to achieve the purpose of alleviating the above symptoms. The principle of dispelling wind and activating blood circulation is to promote blood flow, remove stagnation in the body and enhance the body's disease resistance with the help of Chinese herbal ingredients. In traditional Chinese medicine, "wind" refers to the adverse effects of changes in the external environment on the body, such as cold and humidity; and "blood" refers to the state of qi and blood in the body. The unobstructed flow of qi and blood is the cornerstone of maintaining health. Dispelling wind, activating blood circulation and unblocking collaterals foot bath powder combines a variety of Chinese medicines that have the effects of activating blood circulation and removing blood stasis, warming the meridians and dispersing cold, such as mugwort, safflower, cinnamon twig, chuanxiong, angelica, etc. These medicinal materials are absorbed and utilized by foot bathing, thereby exerting their unique medicinal effects. Foot soaking is a means of dispelling wind and activating blood circulation. The foot is one of the areas with the most dense distribution of meridians in the human body, especially the soles of the feet have many important acupuncture points. By stimulating these acupuncture points, the effect of regulating the whole body's qi and blood can be achieved. On the other hand, foot soaking is simpler and easier than other treatment methods, does not require complicated operations, and is suitable for people of all ages. In addition, hot water soaking can promote local blood circulation, and with the synergistic effect of herbs, it can more effectively relax muscles, relieve fatigue, and improve sleep quality. The whole process is comfortable and pleasant, and easy to stick to. Summary of the invention

[0003] Therefore, based on the above background technology, the purpose of the present invention is to provide a foot bath powder for dispelling wind, activating blood circulation and unblocking meridians and a preparation method thereof.

[0004] The technical effect of the present invention is achieved through the following technical scheme: a foot bath powder for dispelling wind, activating blood circulation and unblocking meridians, which comprises the following components by weight: 10 to 12 parts of ginger powder, 9 to 12 parts of wormwood powder, 8 to 10 parts of angelica powder, 5 to 8 parts of safflower powder, 6 to 8 parts of Chuanxiong powder, 5 to 8 parts of half-maple, 6 to 8 parts of radix polygoni aviculare, 5 to 7 parts of verbena, 18 to 25 parts of sodium alginate, 6 to 12 parts of polyvinyl alcohol, 6 to 9 parts of beta-cyclodextrin, 6 to 8 parts of magnesium sulfate, 9 to 15 parts of sodium bicarbonate, 15 to 20 parts of complex sodium percarbonate, 9 to 12 parts of sea salt, 5 to 7 parts of hydroxypropyl methylcellulose, 3 to 4 parts of moisturizer and 1 to 2 parts of antioxidant.

[0005] Preferably, the moisturizing agent is any one of hyaluronic acid, lecithin and soybean lecithin.

[0006] Preferably, the antioxidant is any one of vitamin C, vitamin E and tea polyphenols.

[0007] Preferably, the specific preparation steps of the composite sodium percarbonate are as follows: A1: Add polyvinyl alcohol to deionized water, heat to 60°C, stir and dissolve evenly to obtain a 5-10wt% polyvinyl alcohol solution; add ethyl cellulose to 70wt% ethanol solution, stir and dissolve evenly to obtain a 2-5wt% ethyl cellulose solution; add chitosan to deionized water, stir and dissolve evenly, and then add glutaraldehyde solution to obtain a 1-2wt% chitosan solution; add sodium stearate to deionized water, heat to 60°C, stir and dissolve evenly to obtain a 1-2wt% sodium stearate solution; A2: Soak the sodium percarbonate in the polyvinyl alcohol solution prepared in step A1, stir at 300 rpm for 15-20 min, centrifuge, filter, and dry at 40° C. for 2 h, then soak in the ethyl cellulose solution prepared in step A1, stir at 200 rpm for 10-15 min, centrifuge, filter, and dry at 45° C. for 1 h to obtain coated sodium percarbonate; A3: soaking the coated sodium percarbonate prepared in step A2 in the chitosan solution prepared in step A1, stirring at 150 rpm for 20-30 min, centrifuging, filtering, and curing at room temperature for 4 h, and then soaking in the sodium stearate solution prepared in step A1, stirring at 80-100 rpm for 10 min, centrifuging, filtering, and drying at 30° C. for 2 h to obtain composite sodium percarbonate; Preferably, in step A1, the ratio of the glutaraldehyde solution to chitosan is 1 mL:2 g.

[0008] Preferably, another aspect of the present invention is to provide a method for preparing a foot bath powder for dispelling wind, activating blood circulation and unblocking collaterals, and the specific preparation steps are as follows: S1: Mix ginger powder, wormwood powder, angelica powder, safflower powder, chuanxiong powder, half-fenghe, radix polygoni lobatae and verbena and add them to deionized water with a total weight of 10 to 15 times, heat to 70 to 80°C, keep constant temperature and stir at a speed of 300 rpm for 60 to 90 minutes, filter, take the supernatant, and evaporate under reduced pressure to 1 / 4 to 1 / 5 of the original volume to obtain a Chinese medicine extract; S2: adding sodium alginate to 100 parts by weight of deionized water, heating to 60°C, stirring to completely dissolve, and obtaining a sodium alginate solution; adding β-cyclodextrin and polyvinyl alcohol to 50 parts by weight of deionized water, heating to 80°C, stirring to completely dissolve, and then cooling to room temperature to obtain a polyvinyl alcohol solution; slowly adding the polyvinyl alcohol solution to the sodium alginate solution, stirring to disperse evenly, and obtaining a carrier solution; S3: slowly adding the Chinese medicine extract prepared in step S1 to the carrier solution prepared in step S2, stirring and dispersing evenly, and then spray drying, setting the parameters of air inlet temperature at 80-100°C, air outlet temperature at 40-60°C, and pressure at 0.1-0.3MPa; after the spray drying is completed, drying at 40°C for 1-2h to obtain Chinese medicine nanoparticles; S4: stirring and mixing the Chinese medicine nanospheres, magnesium sulfate, sodium bicarbonate, composite sodium percarbonate, sea salt, moisturizer and antioxidant under a nitrogen atmosphere to obtain a mixture; adding hydroxypropyl methylcellulose to 10 to 20 parts by weight of deionized water, stirring and dissolving to obtain a hydroxypropyl methylcellulose solution; S5: slowly add the hydroxypropyl methylcellulose solution prepared in step S4 to the mixture, stir and mix evenly, extrude through a 0.5-1 mm granulating screen to form granules, and then dry at 45-50° C. for 2-4 hours to obtain foot bath powder.

[0009] Preferably, in step S1, the specific parameters of the reduced pressure evaporation are a temperature of 50-60°C, a pressure of 150-300 mbar, and a rotation speed of 100-200 rpm.

[0010] The beneficial effects of the present invention are as follows: The present invention adopts spray drying method to make Chinese medicine extract into nano microspheres, which are wrapped in soluble carrier sodium alginate to achieve uniform distribution, prevent drug components from precipitating in foot bath powder, improve absorption efficiency, and thus significantly enhance the efficacy of Chinese medicine components. For example, the blood-tonifying and blood-activating effect of angelica powder and the meridian-activating effect of Chuanxiong powder can play a role in the deep layer of the skin, enhancing the overall drug effect. Magnesium sulfate in foot bath powder dissociates as an electrolyte in water to produce microcurrent, which synergizes with nano-sized Chinese medicine microspheres, significantly improves the skin permeability of Chinese medicine components, and promotes blood circulation. Microcurrent stimulates foot acupuncture points, so that the wind-dispelling, blood-activating, and meridian-dredging components such as ginger powder, wormwood powder, half maple, scutellaria baicalensis, and Chuanxiong powder can penetrate into the deep layer of the skin more quickly, achieving a more efficient wind-dispelling effect. At the same time, the stimulation of microcurrent prolongs the meridian-dredging effect, making the curative effect of foot bath more lasting.

[0011] The present invention utilizes the oxygen bubble effect to release tiny bubbles through slow-release peroxide, and these bubbles provide gentle massage for the foot skin during foot bathing, and physical stimulation helps to improve the skin's absorption efficiency of active ingredients. The bubbles continuously drive tiny Chinese medicine microspheres, so that they keep contact with the skin surface for a long time, further promote the absorption of blood-activating components in angelica powder, safflower pollen and verbena, and accelerate blood circulation. The continuously released oxygen improves the oxygen supply of local tissues, helps relieve fatigue and muscle stiffness, and makes the blood-activating and collateral-draining effects of Chuanxiong and Angelica more significant. Sea salt has natural permeability, can open skin pores, help remove surface impurities and promote the absorption of drug ingredients. The mineral components of sea salt can also supplement trace elements for the skin, and enhance the soothing and fatigue-relieving effects of foot bathing. The combined use of blood-activating components such as ginger powder, Chuanxiong powder, safflower pollen, angelica powder, half maple lotus, and scutellaria baicalensis significantly improves foot microcirculation and improves blood flow. The warming property of ginger combined with the blood-activating effect of Chuanxiong and safflower can help relieve the coldness of the feet, especially for the discomfort of the feet caused by wind, cold and dampness. The combination of safflower and angelica can improve the local blood supply deficiency, nourish the foot skin better, effectively prevent dryness and cracking, and keep the foot skin healthy. In addition, the present invention effectively preserves the activity of the raw materials by preparing the foot bath powder into granules, which is convenient for use and transportation, and avoids the stratification and moisture absorption of the powdered product. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings in the following description are only for the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0013] Figure 1 It is a test chart of the antioxidant performance of the foot bath powder prepared in Examples 1 to 3 of the present invention and Comparative Examples 1 to 3; Figure 2 It is a graph showing the stability test results of the foot bath powder prepared in Example 2 of the present invention and Comparative Examples 1 to 3; Figure 3 It is a test result diagram of oxygen bubble effect of foot bath powder prepared in Example 2 of the present invention and Comparative Examples 1 to 3; Figure 4 It is a test chart of the transdermal absorption rate of the foot bath powder prepared in Example 2 of the present invention and Comparative Examples 1 to 3. DETAILED DESCRIPTION

[0014] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. It should be noted that, unless otherwise specified, the raw materials involved in the present invention are purchased through conventional commercial channels.

[0015] Embodiment 1: A foot bath powder for dispelling wind, activating blood circulation and unblocking meridians, comprising the following components in parts by weight: 10 parts of ginger powder, 9 parts of mugwort powder, 8 parts of angelica powder, 5 parts of safflower powder, 6 parts of chuanxiong powder, 5 parts of half-broomcorn millet, 6 parts of radix polygoni aviculare, 5 parts of verbena, 18 parts of sodium alginate, 6 parts of polyvinyl alcohol, 6 parts of β-cyclodextrin, 6 parts of magnesium sulfate, 9 parts of sodium bicarbonate, 15 parts of complex sodium percarbonate, 9 parts of sea salt, 3 parts of moisturizer and 1 part of antioxidant.

[0016] The specific preparation steps of composite sodium percarbonate are as follows: A1: Add 5g of polyvinyl alcohol to 100mL of deionized water, heat to 60°C, stir and dissolve evenly to obtain a 5wt% polyvinyl alcohol solution; add 2g of ethyl cellulose to 100mL of ethanol solution, stir and dissolve evenly to obtain a 2wt% ethyl cellulose solution; add 1g of chitosan to 100mL of deionized water, stir and dissolve evenly, and then add 0.5mL of glutaraldehyde solution to obtain a 1wt% chitosan solution; add 1g of sodium stearate to 100mL of deionized water, heat to 60°C, stir and dissolve evenly to obtain a 1wt% sodium stearate solution; A2: 10 g of sodium percarbonate was immersed in 100 mL of polyvinyl alcohol solution prepared in step A1, stirred at 300 rpm for 15 min, centrifuged, filtered, and dried at 40° C. for 2 h, and then immersed in 100 mL of ethyl cellulose solution prepared in step A1, stirred at 200 rpm for 10 min, centrifuged, filtered, and dried at 45° C. for 1 h to obtain coated sodium percarbonate; A3: Soak the coated sodium percarbonate prepared in step A2 in 100 mL of chitosan solution prepared in step A1, stir at 150 rpm for 20 min, centrifuge, filter, and cure at room temperature for 4 h, then soak in 100 mL of sodium stearate solution prepared in step A1, stir at 80 rpm for 10 min, centrifuge, filter, and dry at 30° C. for 2 h to obtain composite sodium percarbonate; The specific preparation steps of foot bath powder are as follows: S1: Mix ginger powder, wormwood powder, angelica powder, safflower powder, chuanxiong powder, half-fenghe, radix polygoni lobatae and verbena and add them to 10 times the total weight of deionized water, heat to 70°C, keep constant temperature and stir at a speed of 300 rpm for 60 minutes, filter, take the supernatant, and evaporate under reduced pressure to 1 / 4 of the original volume. The specific parameters are temperature 50°C, pressure 150 mbar, and speed 100 rpm to obtain a Chinese medicine extract; S2: adding sodium alginate to 100 parts by weight of deionized water, heating to 60°C, stirring to completely dissolve, and obtaining a sodium alginate solution; adding β-cyclodextrin and polyvinyl alcohol to 50 parts by weight of deionized water, heating to 80°C, stirring to completely dissolve, and then cooling to room temperature to obtain a polyvinyl alcohol solution; slowly adding the polyvinyl alcohol solution to the sodium alginate solution, stirring to disperse evenly, and obtaining a carrier solution; S3: slowly adding the Chinese medicine extract prepared in step S1 to the carrier solution prepared in step S2, stirring and dispersing evenly, and then spray drying, setting the parameters of the air inlet temperature to 80°C, the air outlet temperature to 40°C, and the pressure to 0.1MPa; after the spray drying is completed, drying at 40°C for 1h to obtain Chinese medicine nanoparticles; S4: stirring and mixing the Chinese medicine nanospheres, magnesium sulfate, sodium bicarbonate, composite sodium percarbonate, sea salt, lecithin and vitamin C in a nitrogen atmosphere to obtain a mixture; adding hydroxypropyl methylcellulose to 10 parts by weight of deionized water, stirring and dissolving to obtain a hydroxypropyl methylcellulose solution; S5: slowly add the hydroxypropyl methylcellulose solution prepared in step S4 to the mixture, stir and mix evenly, extrude through a 0.5 mm granulating screen to form granules, and then dry at 45° C. for 4 hours to obtain foot bath powder.

[0017] Embodiment 2: A foot bath powder for dispelling wind, activating blood circulation and unblocking meridians, comprising the following components in parts by weight: 12 parts of ginger powder, 12 parts of mugwort powder, 10 parts of angelica powder, 8 parts of safflower powder, 8 parts of chuanxiong powder, 8 parts of half-broomcorn millet, 8 parts of radix polygoni avicularis, 7 parts of verbena, 25 parts of sodium alginate, 12 parts of polyvinyl alcohol, 9 parts of β-cyclodextrin, 8 parts of magnesium sulfate, 15 parts of sodium bicarbonate, 20 parts of complex sodium percarbonate, 12 parts of sea salt, 4 parts of moisturizer and 2 parts of antioxidant.

[0018] The specific preparation steps of composite sodium percarbonate are as follows: A1: Add 10g of polyvinyl alcohol to 100mL of deionized water, heat to 60°C, stir and dissolve evenly to obtain a 10wt% polyvinyl alcohol solution; add 5g of ethyl cellulose to 100mL of 70wt% ethanol solution, stir and dissolve evenly to obtain a 5wt% ethyl cellulose solution; add 2g of chitosan to 100mL of deionized water, stir and dissolve evenly, and then add 1mL of glutaraldehyde solution to obtain a 2wt% chitosan solution; add 2g of sodium stearate to 100mL of deionized water, heat to 60°C, stir and dissolve evenly to obtain a 2wt% sodium stearate solution; A2: Sodium percarbonate was immersed in 100 mL of polyvinyl alcohol solution prepared in step A1, stirred at 300 rpm for 20 min, centrifuged, filtered, and dried at 40° C. for 2 h, and then immersed in 100 mL of ethyl cellulose solution prepared in step A1, stirred at 200 rpm for 15 min, centrifuged, filtered, and dried at 45° C. for 1 h to obtain coated sodium percarbonate; A3: Soak the coated sodium percarbonate prepared in step A2 in 100 mL of chitosan solution prepared in step A1, stir at 150 rpm for 30 min, centrifuge, filter, and cure at room temperature for 4 h, then soak in 100 mL of sodium stearate solution prepared in step A1, stir at 100 rpm for 10 min, centrifuge, filter, and dry at 30° C. for 2 h to obtain composite sodium percarbonate; The specific preparation steps of foot bath powder are as follows: S1: Mix ginger powder, wormwood powder, angelica powder, safflower powder, chuanxiong powder, half-fenghe, radix polygoni lobatae and verbena and add them to 15 times the total weight of deionized water, heat to 80°C, keep constant temperature and stir at a speed of 300 rpm for 90 minutes, filter, take the supernatant, and evaporate under reduced pressure to 1 / 5 of the original volume. The specific parameters are temperature 60°C, pressure 300 mbar, and speed 200 rpm to obtain a Chinese medicine extract; S2: adding sodium alginate to 100 parts by weight of deionized water, heating to 60°C, stirring to completely dissolve, and obtaining a sodium alginate solution; adding β-cyclodextrin and polyvinyl alcohol to 50 parts by weight of deionized water, heating to 80°C, stirring to completely dissolve, and then cooling to room temperature to obtain a polyvinyl alcohol solution; slowly adding the polyvinyl alcohol solution to the sodium alginate solution, stirring to disperse evenly, and obtaining a carrier solution; S3: slowly adding the Chinese medicine extract prepared in step S1 to the carrier solution prepared in step S2, stirring and dispersing evenly, and then spray drying, setting the parameters of the air inlet temperature to 90°C, the air outlet temperature to 50°C, and the pressure to 0.3MPa; after the spray drying is completed, drying at 40°C for 2h to obtain Chinese medicine nanoparticles; S4: stirring and mixing the Chinese medicine nanospheres, magnesium sulfate, sodium bicarbonate, composite sodium percarbonate, sea salt, hyaluronic acid and vitamin E in a nitrogen atmosphere to obtain a mixture; adding hydroxypropyl methylcellulose to 20 parts by weight of deionized water, stirring and dissolving to obtain a hydroxypropyl methylcellulose solution; S5: slowly add the hydroxypropyl methylcellulose solution prepared in step S4 to the mixture, stir and mix evenly, extrude through a 1 mm granulating sieve to form granules, and then dry at 50° C. for 2 h to obtain foot bath powder.

[0019] Embodiment 3: A foot bath powder for dispelling wind, activating blood circulation and unblocking meridians, comprising the following components in parts by weight: 11 parts of ginger powder, 10 parts of mugwort powder, 9 parts of angelica powder, 6 parts of safflower powder, 7 parts of chuanxiong powder, 6 parts of half-broomcorn millet, 7 parts of radix polygoni aviculare, 6 parts of verbena, 22 parts of sodium alginate, 10 parts of polyvinyl alcohol, 8 parts of β-cyclodextrin, 7 parts of magnesium sulfate, 12 parts of sodium bicarbonate, 18 parts of complex sodium percarbonate, 10 parts of sea salt, 3.5 parts of moisturizer and 1.5 parts of antioxidant.

[0020] The specific preparation steps of composite sodium percarbonate are as follows: A1: Add 8g of polyvinyl alcohol to 100mL of deionized water, heat to 60°C, stir and dissolve evenly to obtain an 8wt% polyvinyl alcohol solution; add 3g of ethyl cellulose to 100mL of 70wt% ethanol solution, stir and dissolve evenly to obtain a 3wt% ethyl cellulose solution; add 1.5g of chitosan to 100mL of deionized water, stir and dissolve evenly, and then add 0.75mL of glutaraldehyde solution to obtain a 1.5wt% chitosan solution; add 1.5g of sodium stearate to 100mL of deionized water, heat to 60°C, stir and dissolve evenly to obtain a 1.5wt% sodium stearate solution; A2: Soak the sodium percarbonate in 100 mL of the polyvinyl alcohol solution prepared in step A1, stir at 300 rpm for 18 min, centrifuge, filter, and dry at 40° C. for 2 h, then soak in 100 mL of the ethyl cellulose solution prepared in step A1, stir at 200 rpm for 12 min, centrifuge, filter, and dry at 45° C. for 1 h to obtain coated sodium percarbonate; A3: Soak the coated sodium percarbonate prepared in step A2 in 100 mL of chitosan solution prepared in step A1, stir at 150 rpm for 25 min, centrifuge, filter, and cure at room temperature for 4 h, then soak in 100 mL of sodium stearate solution prepared in step A1, stir at 90 rpm for 10 min, centrifuge, filter, and dry at 30° C. for 2 h to obtain composite sodium percarbonate; The specific preparation steps of foot bath powder are as follows: S1: Mix ginger powder, wormwood powder, angelica powder, safflower powder, chuanxiong powder, half-fenghe, radix polygoni lobatae and verbena and add them to 12 times the total weight of deionized water, heat to 75°C, keep constant temperature and stir at a speed of 300 rpm for 80 minutes, filter, take the supernatant, and evaporate under reduced pressure to 1 / 5 of the original volume. The specific parameters are temperature 55°C, pressure 250 mbar, and speed 150 rpm to obtain a Chinese medicine extract; S2: adding sodium alginate to 100 parts by weight of deionized water, heating to 60°C, stirring to completely dissolve, and obtaining a sodium alginate solution; adding β-cyclodextrin and polyvinyl alcohol to 50 parts by weight of deionized water, heating to 80°C, stirring to completely dissolve, and then cooling to room temperature to obtain a polyvinyl alcohol solution; slowly adding the polyvinyl alcohol solution to the sodium alginate solution, stirring to disperse evenly, and obtaining a carrier solution; S3: slowly adding the Chinese medicine extract prepared in step S1 to the carrier solution prepared in step S2, stirring and dispersing the mixture evenly, and then spray drying the mixture, setting the parameters of the air inlet temperature to 100°C, the air outlet temperature to 60°C, and the pressure to 0.3MPa; after the spray drying, drying the mixture at 40°C for 1.5h to obtain Chinese medicine nanoparticles; S4: stirring and mixing the Chinese medicine nanospheres, magnesium sulfate, sodium bicarbonate, composite sodium percarbonate, sea salt, soybean lecithin and tea polyphenols in a nitrogen atmosphere to obtain a mixture; adding hydroxypropyl methylcellulose to 15 parts by weight of deionized water, stirring and dissolving to obtain a hydroxypropyl methylcellulose solution; S5: slowly add the hydroxypropyl methylcellulose solution prepared in step S4 to the mixture, stir and mix evenly, extrude through a 0.5 mm granulating screen to form granules, and then dry at 48° C. for 3 h to obtain foot bath powder.

[0021] Comparative Example 1: The operation of Comparative Example 1 is basically the same as that of Example 2, except that in Comparative Example 1, the Chinese medicine extract is directly used without using the carrier of sodium alginate, β-cyclodextrin and polyvinyl alcohol.

[0022] Comparative Example 2: The operation of Comparative Example 2 is substantially the same as that of Example 2, except that magnesium sulfate is not added in Comparative Example 2.

[0023] Comparative Example 3: The operation of Comparative Example 3 is substantially the same as that of Example 2, except that composite sodium percarbonate is not used in Comparative Example 3.

[0024] Performance Testing: Antioxidant test: Take 2mL DPPH solution and 2mL sample solution (1g of the foot bath powder prepared in Examples 1 to 3 and Comparative Examples 1 to 3 is dissolved in 5mL anhydrous ethanol), mix well, place in dark for 30 minutes, and measure the absorbance at 517nm with anhydrous ethanol solution as reference. The DPPH solution is a 0.1mM solution prepared with anhydrous ethanol as solvent. Calculate the DPPH free radical scavenging rate (scavenging rate (%) = [1-(absorbance of the mixture of sample and DPPH-absorbance of the sample solution without DPPH / absorbance of the solution containing only DPPH] × 100%), repeat the test 3 times, take the average value, and the results are as follows: Figure 1 shown.

[0025] Depend on Figure 1 The results show that the foot bath powder prepared by the present invention has good antioxidant properties. From the results of Comparative Example 1 and Example 2, it can be seen that the antioxidant capacity of the active ingredients of traditional Chinese medicine is significantly affected due to the lack of protection and enhancement of the carrier.

[0026] Stability test: The foot bath powder samples prepared in Example 2 of the present invention and Comparative Examples 1 to 3 were vacuum sealed and placed at a temperature of 30°C and a relative humidity of 90% for 6 months. Samples were taken at the 1st, 2nd, 3rd and 6th month of the test period to measure the mass change and calculate the stability [stability (%) = (sample weight on the nth day of the test - sample weight before the test) / sample weight before the test × 100%]. The results are as follows: Figure 2 shown.

[0027] Depend on Figure 2 The results show that the foot bath powder prepared by the present invention can be effectively preserved for a long time in a high humidity environment. From the results of Comparative Example 1 and Example 2, it can be seen that the lack of carrier material causes the active ingredients to be more easily hygroscopic and aggregate, thereby causing powder agglomeration, resulting in a significant impact on stability and an increase in sample quality. From the results of Comparative Example 2 and Example 2, it can be seen that the presence of magnesium sulfate helps to regulate moisture and prevent sample deliquescence, and the absence of magnesium sulfate leads to a decrease in moisture absorption stability and an increase in sample quality.

[0028] Oxygen bubble effect test: 10 g of the foot bath powder prepared in Example 2 and Comparative Examples 1 to 3 was added to 200 mL of deionized water, and 0.1 M hydrochloric acid was used to react Ca(OH) 2 Perform a titration test, using phenolphthalein as an indicator, take 10 mL of sample at 5 min, 10 min, 20 min, and 30 min for titration, record the hydrochloric acid consumption and the molar mass of calcium hydroxide, and calculate the oxygen release rate: oxygen release rate (moL / L·h) = (hydrochloric acid concentration × hydrochloric acid consumption) / (4 × test sample volume × time). The results are as follows: Figure 3 shown.

[0029] Depend on Figure 3 The results show that the foot bath powder prepared by the present invention can continuously release oxygen within 30 minutes, effectively realizing the oxygen bubble effect; from the results of Comparative Example 1 and Example 2, it can be seen that Comparative Example 1 does not use sodium alginate, β-cyclodextrin and polyvinyl alcohol as nanosphere carriers, the Chinese medicine extract is not encapsulated, the release process of the composite sodium percarbonate is faster, the oxygen release rate quickly reaches the peak value, and the duration is short; the results of Comparative Example 3 and Example 2 show that there is almost no oxygen release capacity due to the lack of composite sodium percarbonate.

[0030] Transdermal absorption test: Obtain skin from a pig ear, and fix the treated pig ear skin model on the test device of a Franz diffusion cell with the skin surface facing the test cell. Take 10 g of the foot bath powder prepared in Example 2 and Comparative Examples 1 to 3, respectively, and dissolve them in 1000 mL of distilled water. Then add them to the test cell of the Franz diffusion cell and cover the skin. The temperature of the diffusion cell is controlled at 50°C. The test is conducted for 30 minutes, and the active ingredient alkaloid is detected every 10 minutes. The transdermal rate results are shown in 4.

[0031] Depend on Figure 4 As a result, the foot bath powder prepared by the present invention has good biological absorption efficiency. It can be seen from the results of Comparative Example 1 and Example 2 that the transdermal absorption rate of Comparative Example 1 increases rapidly but then tends to stabilize. This may be due to the fact that there is no carrier encapsulation of sodium alginate, β-cyclodextrin and polyvinyl alcohol, and the Chinese medicine extract is directly dissolved in the solution, which may cause uneven diffusion of the active ingredients on the skin surface, poor permeability, and rapid release and consumption; it can be seen from the results of Comparative Example 2 and Example 2 that the lack of the microcurrent effect produced by magnesium sulfate cannot effectively promote the skin penetration of the active ingredients of Chinese medicine, and the skin absorption rate is relatively slow; it can be seen from the results of Comparative Example 3 and Example 2 that the lack of composite sodium percarbonate makes it impossible for the foot bath powder to produce oxygen microbubbles, which weakens the skin's motivation to absorb the active ingredients and leads to reduced absorption efficiency.

[0032] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A foot bath powder for dispelling wind, activating blood circulation and unblocking meridians, characterized in that: The composition includes the following components by weight: 10-12 parts of ginger powder, 9-12 parts of wormwood powder, 8-10 parts of angelica powder, 5-8 parts of safflower powder, 6-8 parts of Chuanxiong powder, 5-8 parts of half-maple, 6-8 parts of radix polygoni avicularis, 5-7 parts of verbena, 18-25 parts of sodium alginate, 6-12 parts of polyvinyl alcohol, 6-9 parts of beta-cyclodextrin, 6-8 parts of magnesium sulfate, 9-15 parts of sodium bicarbonate, 15-20 parts of complex sodium percarbonate, 9-12 parts of sea salt, 5-7 parts of hydroxypropyl methylcellulose, 3-4 parts of moisturizer and 1-2 parts of antioxidant.

2. A foot bath powder for dispelling wind, activating blood circulation and unblocking meridians according to claim 1, characterized in that: The moisturizing agent is any one of hyaluronic acid, lecithin and soybean lecithin.

3. A foot bath powder for dispelling wind, activating blood circulation and unblocking collaterals according to claim 2, characterized in that: The antioxidant is any one of vitamin C, vitamin E and tea polyphenols.

4. A foot bath powder for dispelling wind, activating blood circulation and unblocking meridians according to claim 3, characterized in that: The specific preparation steps of the composite sodium percarbonate are as follows: A1: Add polyvinyl alcohol to deionized water, heat, stir and dissolve uniformly to obtain a polyvinyl alcohol solution; add ethyl cellulose to the ethanol solution, stir and dissolve uniformly to obtain an ethyl cellulose solution; add chitosan to deionized water, stir and dissolve uniformly, and then add glutaraldehyde solution to obtain a chitosan solution; add sodium stearate to deionized water, heat, stir and dissolve uniformly to obtain a sodium stearate solution; A2: Soaking sodium percarbonate in the polyvinyl alcohol solution prepared in step A1, stirring, centrifuging, filtering, and drying, and then soaking in the ethyl cellulose solution prepared in step A1, stirring, centrifuging, filtering, and drying to obtain coated sodium percarbonate; A3: soaking the coated sodium percarbonate prepared in step A2 in the chitosan solution prepared in step A1, stirring, centrifuging, filtering, and solidifying at room temperature, and then soaking in the sodium stearate solution prepared in step A1, stirring, centrifuging, filtering, and drying at room temperature to obtain composite sodium percarbonate; In step A1, the ratio of the glutaraldehyde solution to chitosan is 1 mL:2 g.

5. A method for preparing the foot bath powder for dispelling wind, activating blood circulation and unblocking collaterals according to any one of claims 1 to 4, characterized in that: The specific preparation steps are as follows: S1: Mix ginger powder, wormwood powder, angelica powder, safflower powder, chuanxiong powder, half-fenghe, radix polygoni lobatae and verbena and add them into deionized water, heat, keep constant temperature and stir, filter, take the supernatant, concentrate and evaporate under reduced pressure to obtain a Chinese medicine extract; S2: adding sodium alginate to deionized water, heating, stirring to completely dissolve, and obtaining a sodium alginate solution; adding β-cyclodextrin and polyvinyl alcohol to deionized water, heating, stirring to completely dissolve, and then cooling to room temperature to obtain a polyvinyl alcohol solution; slowly adding the polyvinyl alcohol solution to the sodium alginate solution, stirring and dispersing evenly, and obtaining a carrier solution; S3: slowly adding the Chinese medicine extract prepared in step S1 to the carrier solution prepared in step S2, stirring and dispersing evenly, and then spray drying, setting the parameters of air inlet temperature at 80-100°C, air outlet temperature at 40-60°C, and pressure at 0.1-0.3MPa; after the spray drying is completed, drying at 40°C for 1-2h to obtain Chinese medicine nanoparticles; S4: stirring and mixing the Chinese medicine nanospheres, magnesium sulfate, sodium bicarbonate, composite sodium percarbonate, sea salt, moisturizer and antioxidant under a nitrogen atmosphere to obtain a mixture; adding hydroxypropyl methylcellulose to deionized water, stirring and dissolving to obtain a hydroxypropyl methylcellulose solution; S5: slowly adding the hydroxypropyl methylcellulose solution prepared in step S4 into the mixture, stirring and mixing evenly, extruding through a granulating screen to form granules, and then drying to obtain foot bath powder.

6. A method for preparing the foot bath powder for dispelling wind, activating blood circulation and unblocking collaterals according to claim 5, characterized in that: In step S1, the specific parameters of the reduced pressure evaporation are temperature 50-60°C, pressure 150-300 mbar, and rotation speed 100-200 rpm.

Images