Liquid dressing and preparation method thereof

Abstract

The invention provides a liquid dressing and a preparation method thereof, and belongs to the technical field of skin barrier repair and treatment.The liquid dressing comprises four phases of raw materials, a phase D comprises p-hydroxyacetophenone, 1, 2-hexanediol, 1, 3-butanediol and the like, and a phase D comprises p-hydroxyacetophenone, 1, 2-hexanediol, 1, 3-butanediol and the like; the phase C comprises triethanolamine, deionized water and the like; the phase B comprises allantoin, carbomer, various sodium hyaluronates, glycerol and the like; the phase A comprises cetostearyl alcohol, beheneth-22 and the like. The preparation method comprises the following steps: heating the phase A to 80-85 DEG C; heating the phase B to 80-85 DEG C, and keeping the temperature for 20 minutes; adding the phase B into a homogenizer, stirring, adding the phase A, emulsifying at 80 DEG C, cooling and homogenizing; cooling to 75-60 DEG C, adding the phase C, and homogenizing; cooling to below 45 DEG C, adding the phase D, and uniformly stirring; the dressing can form a skin defense film, protect a corium layer, deeply preserve moisture and block bacteria, sodium hyaluronate has the effects of resisting inflammation, repairing and the like, and butyrospermum parkii butter can moisten skin and improve skin resistance.

Description

Technical Field

[0001] The invention belongs to the technical field of skin barrier repair and treatment, and specifically relates to a liquid dressing and a preparation method thereof. Background Art

[0002] In 1983, American scholars proposed the famous "brick wall theory" of the skin barrier. The stratum corneum cells and cells of the skin form a natural protective barrier for the human body through lipids and natural moisturizing factors. In 2011, a major discovery was made in global skin immunology that when the epidermis is intact, symbiotic bacteria such as bacteria, fungi or viruses are not pathogenic. When the skin barrier is damaged, symbiotic bacteria will enter the dermis and trigger an immune inflammatory response. Skin barrier damage is divided into mild, moderate and severe damage. Symptoms of mild damage are dryness, tightness, oiliness, blackheads, uneven skin tone, dull yellow, large pores, poor absorption, and dry lines; symptoms of moderate damage are redness, itching, peeling, spots, closed comedones, and fine lines; symptoms of severe damage are allergies, stinging, itching, red blood, acne, sagging, and wrinkles.

[0003] This solution provides a liquid dressing and a preparation method thereof, aiming to solve the problem of damaged skin barrier. The liquid dressing can quickly form a new skin defense membrane through the human hair follicles and the sebum membrane, play a physical defense protection, effectively protect the dermis, deeply moisturize, and block the entry of external bacteria. At the same time, the sodium hyaluronate with six different molecular combinations has anti-inflammatory, cell regeneration and repair effects, can soothe and comfort the skin, strengthen the stratum corneum, and enhance the skin's resistance. It has a good repair effect on the stratum corneum of eczema, atopic dermatitis (AD), psoriasis, sensitive skin, and hormone-induced skin. In addition, avocado tree butter is a natural oil that moisturizes the skin, has a mild texture and is non-irritating, is rich in multiple vitamins, has a good affinity for the skin, can activate the skin, promote skin microcirculation, increase skin resistance, increase skin permeability, and make the skin naturally breathable. Summary of the invention

[0004] The purpose of the present invention is to provide a liquid dressing and a preparation method thereof, aiming to solve the problems in the prior art that after the skin barrier is damaged, symbiotic bacteria will enter the dermis and trigger an immune inflammatory response, as well as the skin becoming dry and tight, oily, with blackheads, uneven skin color, dark yellow, enlarged pores, poor absorption, dry lines, redness, itching, peeling, spots, closed comedones, fine lines, allergies, tingling, itching, red blood streaks, acne, sagging, wrinkles, etc.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] A liquid dressing and a preparation method thereof, characterized in that it comprises 4 phases of raw materials;

[0007] The four-phase raw materials are composed of A, B, C and D;

[0008] The phase D raw material includes 0.2-0.8 parts of p-hydroxyacetophenone, 0.2-0.8 parts of 1,2-hexanediol, and 1-5 parts of 1,3-butanediol;

[0009] The C phase raw material includes 0.1-0.5 parts of triethanolamine and 0.1-0.5 parts of deionized water;

[0010] The phase B raw materials include 0.1-0.5 parts of allantoin, 0.1-0.5 parts of carbomer, 60-90 parts of deionized water, 0.01-0.8 parts of sodium hyaluronate 3000Da, 0.01-0.08 parts of sodium hyaluronate 20000Da, 0.01-0.08 parts of sodium hyaluronate 50000Da, 0.01-0.08 parts of sodium hyaluronate 200000Da, 0.01-0.08 parts of sodium hyaluronate 500000Da, 0.01-0.08 parts of sodium hyaluronate 1200000Da, 1-5 parts of glycerol, and 0.2-0.5 parts of sodium polyacrylate;

[0011] The raw materials of phase A include 1-3 parts of cetostearyl alcohol (cetostearyl alcohol), 0.5-1.5 parts of behenyl alcohol polyether-22, 1-3 parts of isopropyl myristate, 1-2 parts of avocado butter, 0.2-0.6 parts of phytosteryl isostearate, 1-2 parts of polydimethylsiloxane, 1-3 parts of hydrogenated polydecene, 1-3 parts of hydrogenated polyisobutene, and 1-3 parts of self-emulsifying monoglyceride S-165;

[0012] The preparation method comprises the following steps:

[0013] Step 1: Add phase A to the oil pan, heat, stir and raise the temperature to 80-85℃;

[0014] Step 2: Add phase B to the water pot, stir and heat to 80-85℃, observe if there are any lumps, and keep warm for 20 minutes;

[0015] Step 3: Add phase B to the homogenizer, stir and then add phase A, stir and emulsify at 80℃ for 5 minutes, cool to 70-75℃ and homogenize at 25r / min-45r / min for 1-5 minutes;

[0016] Step 4: Stir and cool to 75-60℃, add phase C, and homogenize at 25r / min-45r / min for 1-5 minutes;

[0017] Step 5: Stir and cool down to below 45°C, add phase D and mix well;

[0018] Step 6: Cool down to 36℃ and discharge.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] 1. In this solution, a new skin defense membrane is quickly formed through the sebum membrane through the human hair follicles, which plays a physical defense protection role, effectively protects the dermis, deeply moisturizes, and blocks the entry of external bacteria. At the same time, the sodium hyaluronate with six different molecular combinations has anti-inflammatory, cell regeneration, and repair effects, soothes the skin, strengthens the stratum corneum, and enhances skin resistance. It has a good repair effect on the stratum corneum of eczema, atopic dermatitis (AD), psoriasis, sensitive skin, and hormone-induced skin. Avocado tree butter is a natural oil that moisturizes the skin, has a mild texture and is non-irritating, is rich in multiple vitamins, has a good affinity for the skin, activates the skin, promotes skin microcirculation, increases skin resistance, increases skin permeability, and allows the skin to breathe naturally.

[0021] 2. In this solution, the liquid dressing can pass through the human hair follicles through the sebum membrane to quickly form a new skin defense membrane, play a physical defense protection, effectively protect the dermis, deeply moisturize, and block the entry of external bacteria. The six different molecular combinations of sodium hyaluronate have anti-inflammatory, cell regeneration, and repair effects. They can soothe and comfort the skin, strengthen the stratum corneum, and enhance skin resistance. They have a good repair effect on the stratum corneum of eczema, atopic dermatitis (AD), psoriasis, sensitive skin, and hormone-induced skin. Avocado tree butter is a natural oil that moisturizes the skin, has a mild texture and is non-irritating, is rich in multiple vitamins, has a good affinity for the skin, can activate the skin, promote skin microcirculation, increase skin resistance, increase skin permeability, and make the skin naturally breathable. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0023] Figure 1 The figure is a flow chart of the liquid dressing and the preparation method thereof of the present invention. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] Example 1

[0026] See also Figure 1 , the present invention provides the following technical solutions:

[0027] A liquid dressing and a preparation method thereof, characterized in that it comprises 4 phases of raw materials;

[0028] The four-phase raw materials are composed of A, B, C and D;

[0029] The phase D raw material includes 0.2-0.8 parts of p-hydroxyacetophenone, 0.2-0.8 parts of 1,2-hexanediol, and 1-5 parts of 1,3-butanediol;

[0030] The C phase raw material includes 0.1-0.5 parts of triethanolamine and 0.1-0.5 parts of deionized water;

[0031] The phase B raw materials include 0.1-0.5 parts of allantoin, 0.1-0.5 parts of carbomer, 60-90 parts of deionized water, 0.01-0.8 parts of sodium hyaluronate 3000Da, 0.01-0.08 parts of sodium hyaluronate 20000Da, 0.01-0.08 parts of sodium hyaluronate 50000Da, 0.01-0.08 parts of sodium hyaluronate 200000Da, 0.01-0.08 parts of sodium hyaluronate 500000Da, 0.01-0.08 parts of sodium hyaluronate 1200000Da, 1-5 parts of glycerol, and 0.2-0.5 parts of sodium polyacrylate;

[0032] The raw materials of phase A include 1-3 parts of cetostearyl alcohol (cetostearyl alcohol), 0.5-1.5 parts of behenyl alcohol polyether-22, 1-3 parts of isopropyl myristate, 1-2 parts of avocado butter, 0.2-0.6 parts of phytosteryl isostearate, 1-2 parts of polydimethylsiloxane, 1-3 parts of hydrogenated polydecene, 1-3 parts of hydrogenated polyisobutene, and 1-3 parts of self-emulsifying monoglyceride S-165;

[0033] The preparation method comprises the following steps:

[0034] Step 1: Add phase A to the oil pan, heat, stir and raise the temperature to 80-85℃;

[0035] Step 2: Add phase B to the water pot, stir and heat to 80-85℃, observe if there are any lumps, and keep warm for 20 minutes;

[0036] Step 3: Add phase B to the homogenizer, stir and then add phase A, stir and emulsify at 80℃ for 5 minutes, cool to 70-75℃ and homogenize at 25r / min-45r / min for 1-5 minutes;

[0037] Step 4: Stir and cool to 75-60℃, add phase C, and homogenize at 25r / min-45r / min for 1-5 minutes;

[0038] Step 5: Stir and cool down to below 45°C, add phase D and mix well;

[0039] Step 6: Cool down to 36℃ and discharge;

[0040] In a specific embodiment of the present invention,

[0041] [Example 1] A liquid dressing comprises 4 phases of raw materials, and the specific composition is as follows:

[0042] Phase D raw materials: 0.2 parts of p-hydroxyacetophenone, 0.2 parts of 1.2-hexanediol, and 1 part of 1,3-butanediol; p-hydroxyacetophenone has antioxidant and antibacterial effects; 1.2-hexanediol can enhance the moisturizing effect and has antibacterial effects; 1,3-butanediol has moisturizing and antibacterial functions;

[0043] Phase C raw materials: 0.1 part of triethanolamine and 0.1 part of deionized water; triethanolamine can adjust the pH value and enhance stability;

[0044] Phase B raw materials: 0.1 part of allantoin, 0.1 part of carbomer, 60 parts of deionized water, 0.01 part of sodium hyaluronate 3000Da, 0.01 part of sodium hyaluronate 20000Da, 0.01 part of sodium hyaluronate 50000Da, 0.01 part of sodium hyaluronate 200000Da, 0.01 part of sodium hyaluronate 500000Da, 0.01 part of sodium hyaluronate 1200000Da, 1 part of glycerol, 0.2 part of sodium polyacrylate; Allantoin has the effect of moisturizing and promoting cell repair; Carbomer can increase the viscosity and stability of the dressing; The combination of sodium hyaluronate with various molecular weights has anti-inflammatory, cell regeneration and repair effects, can soothe and comfort the skin, strengthen the stratum corneum, and enhance the skin's resistance; Glycerin has a moisturizing effect; Sodium polyacrylate can enhance moisture retention and stability;

[0045] Phase A ingredients: 1 part of cetostearyl alcohol (cetostearyl alcohol), 0.5 parts of beheneth-22, 1 part of isopropyl myristate, 1 part of avocado butter, 0.2 parts of phytosteryl isostearate, 1 part of polydimethylsiloxane, 1 part of hydrogenated polydecene, 1 part of hydrogenated polyisobutene, 1 part of self-emulsifying monoglyceride S-165; cetostearyl alcohol can enhance the moisturizing property of the skin; beheneth-22 has an emulsifying effect; isopropyl myristate can moisturize the skin; The fruit butter of the oleifera tree can moisturize the skin, has a mild texture and is non-irritating. It is rich in various vitamins and has a good affinity for the skin. It can activate the skin, promote skin microcirculation, increase skin resistance, increase skin permeability, and make the skin naturally breathable; phytosteryl isostearate has a nourishing and moisturizing effect; polydimethylsiloxane can improve the touch of the skin; hydrogenated polydecene and hydrogenated polyisobutylene have a moisturizing and nourishing effect; self-emulsifying monoglyceride S-165 has an emulsifying and stabilizing effect;

[0046] [Example 2] A liquid dressing comprising 4 phases of raw materials, the specific composition is as follows:

[0047] Phase D raw materials: 0.5 parts of p-hydroxyacetophenone, 0.5 parts of 1.2-hexanediol, and 3 parts of 1,3-butanediol;

[0048] Phase C raw materials: 0.3 parts of triethanolamine and 0.3 parts of deionized water;

[0049] Phase B raw materials: 0.3 parts of allantoin, 0.3 parts of carbomer, 75 parts of deionized water, 0.4 parts of sodium hyaluronate 3000Da, 0.04 parts of sodium hyaluronate 20000Da, 0.04 parts of sodium hyaluronate 50000Da, 0.04 parts of sodium hyaluronate 200000Da, 0.04 parts of sodium hyaluronate 500000Da, 0.04 parts of sodium hyaluronate 1200000Da, 3 parts of glycerin, 0.35 parts of sodium polyacrylate;

[0050] Phase A raw materials: 2 parts of cetostearyl alcohol (cetostearyl alcohol), 1 parts of behenyl alcohol polyether-22, 2 parts of isopropyl myristate, 1.5 parts of avocado butter, 0.4 parts of phytosteryl isostearate, 1.5 parts of polydimethylsiloxane, 2 parts of hydrogenated polydecene, 2 parts of hydrogenated polyisobutene, 2 parts of self-emulsifying monoglyceride S-165;

[0051] [Example 3] A liquid dressing, comprising 4 phases of raw materials, the specific composition is as follows:

[0052] Phase D raw materials: 0.8 parts of p-hydroxyacetophenone, 0.8 parts of 1.2-hexanediol, and 5 parts of 1,3-butanediol;

[0053] Phase C raw materials: 0.5 parts of triethanolamine and 0.5 parts of deionized water;

[0054] Phase B raw materials: 0.5 parts of allantoin, 0.5 parts of carbomer, 90 parts of deionized water, 0.8 parts of sodium hyaluronate 3000Da, 0.08 parts of sodium hyaluronate 20000Da, 0.08 parts of sodium hyaluronate 50000Da, 0.08 parts of sodium hyaluronate 200000Da, 0.08 parts of sodium hyaluronate 500000Da, 0.08 parts of sodium hyaluronate 1200000Da, 5 parts of glycerol, 0.5 parts of sodium polyacrylate;

[0055] Phase A raw materials: 3 parts of cetostearyl alcohol (cetostearyl alcohol), 1.5 parts of behenyl alcohol polyether-22, 3 parts of isopropyl myristate, 2 parts of avocado butter, 0.6 parts of phytosteryl isostearate, 2 parts of polydimethylsiloxane, 3 parts of hydrogenated polydecene, 3 parts of hydrogenated polyisobutene, 3 parts of self-emulsifying monoglyceride S-165;

[0056] In the above embodiments, the functions of the raw materials are as described above. Through reasonable matching and combination, the liquid dressing can effectively protect the skin barrier, deeply moisturize, anti-inflammatory repair, soothe the skin, and enhance the skin's resistance;

[0057] [Example 4] The preparation method of the liquid dressing comprises the following steps:

[0058] Step 1: Add phase A into the oil pan, heat, stir and raise the temperature to 80-85°C; the purpose of this step is to fully melt and mix the raw materials of phase A to prepare for the subsequent emulsification process;

[0059] Step 2: Add phase B into the water pot, stir and heat to 80-85℃, observe if there are any lumps, and keep warm for 20 minutes; the purpose of this step is to fully dissolve and disperse the raw materials of phase B to ensure that there are no lumps. Keeping warm for 20 minutes can further improve the mixing uniformity of the raw materials;

[0060] Step 3: Add phase B to the homogenizer, stir and then add phase A, stir and emulsify at 80℃ for 5 minutes, cool down to 70-75℃ and homogenize at 25r / min-45r / min for 1-5 minutes; in this step, phase A and phase B are fully emulsified by the homogenizer to form a uniform emulsion system, and cooling and homogenizing can further improve the stability and texture of the emulsion;

[0061] Step 4: Stir and cool to 75-60℃, add phase C, and homogenize at 25r / min-45r / min for 1-5 minutes; adding phase C can adjust the pH value and stability of the dressing, and the homogenization process helps the raw materials of phase C to be evenly dispersed in the system;

[0062] Step 5: Stir and cool down to below 45°C, add phase D and mix well; p-hydroxyacetophenone, 1,2-hexanediol and 1,3-butanediol in phase D have antioxidant, antibacterial and moisturizing effects. Adding and mixing at a lower temperature can ensure their activity and effect;

[0063] Step 6: Cool down to 36°C and discharge; cool the prepared liquid dressing to 36°C and discharge for subsequent packaging and use;

[0064] [Example 5] In the actual preparation process, strictly following the above steps can ensure that the raw materials are fully mixed and play their respective functions, thereby preparing a liquid dressing with stable performance and good effect. Through the above preparation method, the liquid dressing can have good stability, moisturizing and repair functions, and is suitable for skin barrier repair and treatment.

[0065] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A liquid dressing and a preparation method thereof, characterized in that: It includes 4 phase raw materials; The four-phase raw materials are composed of A, B, C and D; The phase D raw material includes 0.2-0.8 parts of p-hydroxyacetophenone, 0.2-0.8 parts of 1,2-hexanediol, and 1-5 parts of 1,3-butanediol; The C phase raw material includes 0.1-0.5 parts of triethanolamine and 0.1-0.5 parts of deionized water; The phase B raw materials include 0.1-0.5 parts of allantoin, 0.1-0.5 parts of carbomer, 60-90 parts of deionized water, 0.01-0.8 parts of sodium hyaluronate 3000Da, 0.01-0.08 parts of sodium hyaluronate 20000Da, 0.01-0.08 parts of sodium hyaluronate 50000Da, 0.01-0.08 parts of sodium hyaluronate 200000Da, 0.01-0.08 parts of sodium hyaluronate 500000Da, 0.01-0.08 parts of sodium hyaluronate 1200000Da, 1-5 parts of glycerol, and 0.2-0.5 parts of sodium polyacrylate; The raw materials of phase A include 1-3 parts of cetostearyl alcohol (cetostearyl alcohol), 0.5-1.5 parts of behenyl alcohol polyether-22, 1-3 parts of isopropyl myristate, 1-2 parts of avocado butter, 0.2-0.6 parts of phytosteryl isostearate, 1-2 parts of polydimethylsiloxane, 1-3 parts of hydrogenated polydecene, 1-3 parts of hydrogenated polyisobutene, and 1-3 parts of self-emulsifying monoglyceride S-165; The preparation method comprises the following steps: Step 1: Add phase A to the oil pan, heat, stir and raise the temperature to 80-85℃; Step 2: Add phase B to the water pot, stir and heat to 80-85℃, observe if there are any lumps, and keep warm for 20 minutes; Step 3: Add phase B to the homogenizer, stir and then add phase A, stir and emulsify at 80℃ for 5 minutes, cool to 70-75℃ and homogenize at 25r / min-45r / min for 1-5 minutes; Step 4: Stir and cool to 75-60℃, add phase C, and homogenize at 25r / min-45r / min for 1-5 minutes; Step 5: Stir and cool down to below 45°C, add phase D and mix well; Step 6: Cool down to 36℃ and discharge.

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