Micro-needle high-speed implanter

Abstract

The invention discloses a microneedle high-speed implanter, and relates to the technical field of medical instruments, and the microneedle high-speed implanter comprises a cylindrical cavity, a sealing cover, sealing rubber, a microneedle storage sheet and a microneedle. The microneedle storage piece is used for storing microneedles, a limiting ring is arranged in the microneedle storage piece and used for fixing the microneedles, the microneedles are nail-shaped, and when the microneedle storage piece is used, the microneedle storage piece containing the microneedles is embedded into the columnar cavity, and the sealing cover is fixed to the columnar cavity through threads and sealed through the sealing rubber. Compressed gas enters the microneedle high-speed implanter through the rapid gas pipe connector on the sealing cover, pushes the microneedle to be separated from the microneedle storage piece, continuously accelerates in the acceleration trajectory of the columnar cavity and finally flies out at a certain speed. And after the flying-out microneedle is in contact with the skin, the conical needle tip punctures into the skin, and the base is blocked to stay outside the skin, so that a specific puncture depth is realized. The invention aims to realize efficient implantation of the microneedle by utilizing the hardening phenomenon of the skin at a high strain rate.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a microneedle high-speed implanter. Background Art

[0002] Microneedle technology has become the focus of attention as a unique, painless, minimally invasive new generation of transdermal delivery technology, providing an opportunity to solve the shortcomings of subcutaneous injections and transdermal patches. Microneedle patches are mainly composed of two parts, a base and micron-sized needles (100-3000μm) located on the base, which can break through the natural barrier of the stratum corneum of the skin and have been used in the delivery of drug molecules, antibiotics, vitamins, antibodies, proteins, vaccines, nucleic acids, and cells. Soluble microneedles are considered to be the most promising microneedles for clinical application due to their simple preparation methods and good biocompatibility. The inability to evenly distribute force to each microneedle, the viscoelastic deformation of the skin offsets the penetration depth of the microneedle, and the soluble microneedle tip is softened due to excessive exposure to a humid environment (such as humid air, tissue fluid) and affects subsequent penetration. These problems make manual puncture have great differences in puncture efficiency and depth, thereby affecting the bioavailability of the drug.

[0003] The use of a microneedle implanter can improve the penetration efficiency and depth of microneedles and reduce the fluctuation of drug delivery efficiency. The implanter is usually composed of a flat plate, an exciter and a power source. When in use, the power source accelerates the flat plate, thereby driving the microneedles attached to the flat plate to impact and penetrate the skin. According to the power source provided during use, it can be divided into the following categories: (1) Powered by a spring. When in use, the microneedles are attached to the flat plate, and energy is stored by compressing the spring. At the moment of excitation, the flat plate carries the microneedles to impact the skin. This is the most common form. (2) Powered by an electromagnetic. The magnetic force generated by the coil is used to push the flat plate. The system can continuously adjust the penetration speed of the microneedles, thereby effectively coping with skin deformation. (3) Powered by the thumb. It is very convenient to provide force with the thumb, and the device is relatively simple. For example, the elasticity of carboxymethyl cellulose film (CMC) is used to accelerate the penetration of the microneedles into the skin at the moment the CMC film breaks. When using a microneedle implanter, the microneedle application force must be considered. If it is not properly controlled, the pressure used will be lower than the minimum pressure required for penetration, and the microneedle will not be able to penetrate the stratum corneum of the skin to reach the drug delivery site; if the pressure is too high, the flat structure will impact the skin, causing damage and pain. In addition, the skin properties of each person are different, which results in obvious differences in puncture depth when different patients use the same microneedle implanter. Therefore, the application force of the microneedle should meet the needs of different patients as much as possible. Summary of the invention

[0004] The present invention is mainly used to solve the problem that the current microneedle implanter faces differences in application force and puncture depth control for different patients, and provides a microneedle high-speed implanter. The microneedle high-speed implanter aims to reduce the deformation of the skin during high-speed puncture of the microneedle by utilizing the hardening phenomenon of the skin at a high strain rate. The microneedle high-speed implanter can directly accelerate a single microneedle, and the speed of the microneedle can fully meet the needs of different patients. The microneedle is designed in the shape of a nail, consisting of a conical needle tip and a base. During the puncture process, only the conical needle tip will enter the skin, and the base can effectively control the puncture depth to prevent the puncture from being too deep to damage the deep part of the skin and cause pain to the patient. At the same time, the kinetic energy stored in the small-sized microneedle will not cause excessive damage to the skin.

[0005] In order to achieve the above technical objectives, the present invention adopts the following technical solutions:

[0006] A microneedle high-speed implanter, comprising:

[0007] A cylindrical cavity, wherein an accelerating trajectory is arranged in the cylindrical cavity;

[0008] A sealing cover, the sealing cover is connected to the columnar cavity, and the sealing cover is provided with a quick air pipe joint;

[0009] Sealing rubber, the sealing rubber is embedded in the groove of the columnar cavity;

[0010] A microneedle storage sheet, which is used to store microneedles and is embedded in the groove of the columnar cavity;

[0011] Microneedles, stored in microneedle reservoirs.

[0012] When in use, the microneedle storage sheet containing microneedles is embedded into the groove of the columnar cavity, and then the sealing cover is connected to the columnar cavity through threads, and the sealing rubber is compressed for sealing. After the compressed gas enters from the quick air pipe joint of the sealing cover, the microneedle is pushed out of the microneedle storage sheet into the acceleration trajectory, and continuously accelerates in the acceleration trajectory and flies out at a sufficient speed. After the microneedle contacts the skin, the conical needle tip can puncture into the skin, and the base can limit the further puncture of the microneedle, thereby achieving the predetermined puncture depth. After use, open the sealing cover and replace a new microneedle storage sheet for the next use.

[0013] Preferably, the columnar cavity has multiple acceleration trajectories for high-speed implantation of multiple microneedles.

[0014] Preferably, the acceleration trajectory of the columnar cavity is distributed in the sealing rubber.

[0015] Preferably, the columnar cavity and the sealing cover are connected by threads and can be easily disassembled.

[0016] Preferably, the connection between the columnar cavity and the sealing cover can be sealed by compressing sealing rubber.

[0017] Preferably, the inner diameter of the storage cavity of the microneedle storage sheet is the same as the acceleration trajectory, and has two layers of limiting rings for fixing the microneedles.

[0018] Preferably, the microneedle storage sheet is embedded in the groove of the columnar cavity and aligned with the acceleration trajectory.

[0019] Preferably, the microneedle is individually separated, the microneedle is in the shape of a nail, and consists of a conical needle tip and a base, the conical needle tip contains a drug, and the base does not contain a drug, and the microneedle is composed of a biocompatible polymer.

[0020] Preferably, the size of the microneedle base is slightly smaller than the acceleration trajectory, and the microneedle base limits excessive puncture of the microneedle.

[0021] Preferably, the microneedle high-speed implanter accelerates the microneedle to a speed sufficiently greater than the puncture speed requirement.

[0022] The present invention is based on the principle of strain hardening of the skin at high strain rates. The microneedle is accelerated by compressed gas until the speed is sufficiently greater than the puncture speed. The microneedle can effectively reduce skin deformation during high-speed puncture, and the nail-shaped design of the microneedle can accurately achieve the preset puncture depth of the microneedle without considering the application force of the microneedle implanter.

[0023] Compared with the traditional microneedle drug delivery technology widely used in the current market, the microneedle high-speed implanter introduced by the present invention has achieved significant progress in the field of microneedle therapy by virtue of its unique technical advantages, which are specifically reflected in the following aspects:

[0024] 1. Innovative integration of precision control and strain hardening

[0025] The core of the present invention is to cleverly utilize the strain hardening phenomenon exhibited by skin tissue under high strain rates. This physiological characteristic means that when a high-speed impact is applied to the skin in a very short period of time, the skin will instantly harden, thereby reducing deformation and resistance during the puncture process. The application of this principle not only greatly improves the success rate and stability of microneedles penetrating the skin, but also significantly reduces the pain and discomfort caused by puncture to patients. By precisely controlling the puncture speed of the nail-shaped microneedles, the present invention can ensure a consistent and controllable puncture depth in skin tissues of different types and thicknesses, effectively solving the problem of different puncture effects caused by individual differences among patients. This ability to precisely control is of vital importance for improving treatment efficiency and ensuring accurate delivery of drugs to the target area.

[0026] 2. Double improvement of equipment simplification and operation convenience

[0027] The microneedle high-speed implanter of the present invention pursues extreme simplicity and efficiency in design. Its compact structure and streamlined components not only reduce production costs, but also make the maintenance and upkeep of the equipment in daily use simple and easy. This simple design concept directly reduces the technical threshold for medical staff and non-professionals when using microneedles for drug delivery. Even in situations where there are no professional nurses or doctors present (such as unattended areas of hospitals at night, remote areas, or emergency rescue sites), drug implantation operations can be easily completed. In addition, the implanter also has good automation potential. By integrating advanced sensors and control systems, it can achieve automatic positioning, depth adjustment, and speed optimization, further improving the convenience and safety of operation.

[0028] 3. Potential for widespread application and social value

[0029] The microneedle high-speed implanter of the present invention has shown broad application prospects in the medical field. It is not only suitable for conventional medical institutions, providing patients with a more comfortable and efficient drug administration experience, but also plays an important role in special environments, such as quickly providing life-support drugs to the wounded in battlefield first aid, or quickly carrying out large-scale vaccination during an epidemic outbreak, effectively alleviating the problem of tight medical resources. In addition, the popularization of this technology will also promote the development of personalized medicine and telemedicine, provide convenient medical services for patients in remote areas and with limited mobility, and demonstrate its great social value in improving the health level of the whole people and promoting the advancement of medical technology. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0031] Figure 1 It is a structural diagram of the microneedle high-speed implanter of the present invention;

[0032] Figure 2 is a cross-sectional view of the microneedle high-speed implanter of the present invention;

[0033] Figure 3 is a cross-sectional view of the columnar cavity of the microneedle high-speed implanter of the present invention;

[0034] Figure 4 is a cross-sectional view of a microneedle of a microneedle high-speed implanter of the present invention;

[0035] Figure 5 is a cross-sectional view of a microneedle storage sheet of a microneedle high-speed implanter of the present invention;

[0036] Figure 6 is a cross-sectional view of a microneedle storage sheet loaded with microneedles of a microneedle high-speed implanter of the present invention;

[0037] Figure 7 It is a cross-sectional view of the sealing cover of the microneedle high-speed implanter of the present invention. DETAILED DESCRIPTION

[0038] The present invention is described in more detail below in conjunction with the accompanying drawings and embodiments, but the present invention is not limited thereto. For those skilled in the art, several improvements and modifications can be made without departing from the principles of the present invention, and these improvements and modifications are also considered to be within the scope of protection of the present invention. The contents not described in detail in this specification belong to the prior art known to professional and technical personnel in the field.

[0039] The present invention combines Figure 1-7 , the specific embodiments are as follows:

[0040] A microneedle high-speed implanter comprises a columnar cavity 5, a sealing cover 2, a sealing rubber 1, a microneedle storage 3, and a microneedle 4. A groove 14 is provided on the surface of one end of the columnar cavity 5 with a thread for the sealing rubber 1 to be embedded, and a groove 6 is provided for the microneedle storage sheet 3 to be embedded. A through acceleration trajectory 7 is provided in the columnar cavity 5, and the acceleration trajectory 7 is distributed in the sealing rubber 1. The microneedle 4 is in the shape of a nail, and is composed of a conical needle tip 8 and a base 9. The conical needle tip 8 contains a drug, and the base 9 does not contain a drug. The microneedle is composed of a biocompatible polymer. The microneedle 4 can enter the drug storage cavity of the microneedle storage sheet 3 by slightly pressing. Two limiting rings 12 are provided in the drug storage cavity 11 of the microneedle storage sheet 3 to keep the microneedle 4 in the microneedle storage sheet 3. A groove 10 is provided on the side of the microneedle storage sheet 3 for easy removal.

[0041] In the process of elaborating on the use of the innovative technology of the present invention, we have to emphasize its exquisite design and its significant contribution to the advancement of modern medicine, beauty and personal care. First, the microneedle storage sheet 3 carrying the precision microneedles 4 is accurately embedded in the groove 6 of the columnar cavity 5. This process not only reflects the high precision of the manufacturing process, but also ensures the stable fixation of the microneedles before firing, avoiding performance degradation caused by shaking or misalignment. The design of the groove 6 has been carefully calculated to maximize the compactness and firing efficiency of the microneedle arrangement, laying a solid foundation for the subsequent rapid response.

[0042] Next, the sealing cover 2 is tightly combined with the columnar cavity 5 through a precise thread design. This step not only realizes the physical closure of the equipment, but more importantly, by compressing the sealing rubber 1, a sealing barrier is constructed, which effectively prevents gas leakage and the intrusion of external pollutants, ensuring the purity and safety of the internal environment.

[0043] As a key component of the supply and demand device, the design of the quick air pipe connector 13 also demonstrates the advanced nature of the technology. It not only supports efficient and stable gas transmission, but also has the characteristics of quick connection and disconnection, which greatly simplifies the operation process and improves work efficiency. It is worth mentioning that in some advanced versions, the quick air pipe connector 13 is innovatively designed as an adjustable mouthpiece. This change not only broadens the diversity of energy supply (for example, in addition to compressed gas, artificial blowing can also be used for acceleration), but also gives users more operational flexibility and personalized choices, making the technology more adaptable to diverse application scenarios and user needs.

[0044] The firing process of the microneedle 4 is the most eye-catching part of the whole technology. With the rapid influx of compressed gas, the microneedle undergoes a high-speed and stable journey in the accelerated trajectory 7 until it reaches a speed sufficient to penetrate the skin without damaging surrounding tissues. This process not only relies on precise trajectory design, but also benefits from the selection of microneedle materials and breakthroughs in processing technology, which ensure the stability of the microneedle in high-speed motion and the consistency of the puncture effect.

[0045] When the microneedle 4 penetrates the skin at just the right speed, its conical needle tip 8 easily penetrates the epidermis with its unique geometry, while the wide base 9 stays firmly outside due to the resistance of the skin surface. This design subtly controls the puncture depth and avoids the discomfort and risks that may be caused by too deep or too shallow. This ability to accurately control the puncture depth is undoubtedly a major technological advancement in the fields of drug delivery, cosmetic treatment and biosensing, making the treatment process safer, more efficient and personalized.

[0046] Finally, regarding the maintenance and reuse of the device, the design of simply replacing the microneedle reservoir greatly improves the user experience and cost-effectiveness. Users do not need to disassemble or clean the entire device in a complicated manner. They only need to replace the used microneedle reservoir to quickly prepare for the next treatment. This plug-and-play convenience is undoubtedly a major innovation to traditional methods.

Claims

1. A microneedle high-speed implanter, characterized in that: The microneedle high-speed implanter comprises: A cylindrical cavity, wherein an accelerating trajectory is arranged in the cylindrical cavity; A sealing cover, the sealing cover is connected to the columnar cavity, and the sealing cover is provided with a quick air pipe joint; Sealing rubber, the sealing rubber is embedded in the groove of the columnar cavity; A microneedle storage sheet, which is used to store microneedles and is embedded in the groove of the columnar cavity; Microneedles, stored in microneedle reservoirs.

2. The microneedle high-speed implanter according to claim 1, characterized in that: The columnar cavity has multiple accelerating trajectories and is used for high-speed implantation of multiple microneedles.

3. The microneedle high-speed implanter according to claim 1, characterized in that: The acceleration trajectory of the columnar cavity is distributed in the sealing rubber.

4. The microneedle high-speed implanter according to claim 1, characterized in that: The columnar cavity and the sealing cover are connected via threads and can be easily disassembled.

5. The microneedle high-speed implanter according to claim 1, characterized in that: The connection between the columnar cavity and the sealing cover can be sealed by compressing the sealing rubber.

6. The microneedle high-speed implanter according to claim 1, characterized in that: The inner diameter of the storage cavity of the microneedle storage sheet is the same as that of the accelerated trajectory, and has two layers of limiting rings for fixing the microneedles.

7. The microneedle high-speed implanter according to claim 1, characterized in that: The microneedle storage sheet is embedded in the groove of the columnar cavity and is aligned with the acceleration trajectory.

8. The microneedle high-speed implanter according to claim 1, characterized in that: The microneedle is individually separated and in the shape of a nail, and is composed of a conical needle tip and a base. The conical needle tip contains medicine, and the base does not contain medicine. The microneedle is composed of biocompatible polymers.

9. The microneedle high-speed implanter according to claim 1, characterized in that: The size of the microneedle base is slightly smaller than the accelerating trajectory, and the microneedle base limits excessive puncture of the microneedle.

10. The microneedle high-speed implanter according to claim 1, characterized in that: The microneedle high-speed implanter accelerates the microneedle to a speed sufficiently greater than the puncture speed requirement.

Images